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Compile Data Set for Download or QSAR

Found 330 hits of ic50 data for polymerid = 9391   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337019
PNG
(US9745291, Compound 65 | US9765068, Compound 65)
Show SMILES NS(=O)(=O)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H25N3O5S/c21-29(26,27)19-8-4-3-7-18(19)28-14-20(25)22-11-17(24)13-23-10-9-15-5-1-2-6-16(15)12-23/h1-8,17,24H,9-14H2,(H,22,25)(H2,21,26,27)
PDB

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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337020
PNG
(US9745291, Compound 66 | US9765068, Compound 66)
Show SMILES OC(CNC(=O)COc1cccc2ccccc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H26N2O3/c27-21(16-26-13-12-18-6-1-2-8-20(18)15-26)14-25-24(28)17-29-23-11-5-9-19-7-3-4-10-22(19)23/h1-11,21,27H,12-17H2,(H,25,28)
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337021
PNG
(US9745291, Compound 67 | US9765068, Compound 67)
Show SMILES O[C@H](CNC(=O)COc1ccccc1-c1cc[nH]n1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H26N4O3/c28-19(15-27-12-10-17-5-1-2-6-18(17)14-27)13-24-23(29)16-30-22-8-4-3-7-20(22)21-9-11-25-26-21/h1-9,11,19,28H,10,12-16H2,(H,24,29)(H,25,26)/t19-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337022
PNG
(US9745291, Compound 68 | US9765068, Compound 68)
Show SMILES O[C@@H](CNC(=O)COc1ccccc1-c1cc[nH]n1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H26N4O3/c28-19(15-27-12-10-17-5-1-2-6-18(17)14-27)13-24-23(29)16-30-22-8-4-3-7-20(22)21-9-11-25-26-21/h1-9,11,19,28H,10,12-16H2,(H,24,29)(H,25,26)/t19-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337024
PNG
(US9745291, Compound 70 | US9765068, Compound 70)
Show SMILES OC(CNC(=O)COc1ccc2cnn(C3CCNCC3)c2c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C26H33N5O3/c32-23(17-30-12-9-19-3-1-2-4-21(19)16-30)15-28-26(33)18-34-24-6-5-20-14-29-31(25(20)13-24)22-7-10-27-11-8-22/h1-6,13-14,22-23,27,32H,7-12,15-18H2,(H,28,33)
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337025
PNG
(US9745291, Compound 71 | US9765068, Compound 71)
Show SMILES CN1CCC(CC1)n1ncc2ccc(OCC(=O)NCC(O)CN3CCc4ccccc4C3)cc12
Show InChI InChI=1S/C27H35N5O3/c1-30-11-9-23(10-12-30)32-26-14-25(7-6-21(26)15-29-32)35-19-27(34)28-16-24(33)18-31-13-8-20-4-2-3-5-22(20)17-31/h2-7,14-15,23-24,33H,8-13,16-19H2,1H3,(H,28,34)
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337027
PNG
(US9745291, Compound 73 | US9765068, Compound 73)
Show SMILES C[C@@H](Oc1cccc2cccnc12)C(=O)NC[C@H](O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H27N3O3/c1-17(30-22-10-4-8-19-9-5-12-25-23(19)22)24(29)26-14-21(28)16-27-13-11-18-6-2-3-7-20(18)15-27/h2-10,12,17,21,28H,11,13-16H2,1H3,(H,26,29)/t17-,21+/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337028
PNG
(US9745291, Compound 74 | US9765068, Compound 74)
Show SMILES C[C@@H](Oc1cccc2cccnc12)C(=O)NC[C@@H](O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H27N3O3/c1-17(30-22-10-4-8-19-9-5-12-25-23(19)22)24(29)26-14-21(28)16-27-13-11-18-6-2-3-7-20(18)15-27/h2-10,12,17,21,28H,11,13-16H2,1H3,(H,26,29)/t17-,21-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337029
PNG
(US9745291, Compound 75 | US9765068, Compound 75)
Show SMILES OC(CNC(=O)COc1cccc(CN2CCOCC2)c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H33N3O4/c29-23(18-28-9-8-21-5-1-2-6-22(21)17-28)15-26-25(30)19-32-24-7-3-4-20(14-24)16-27-10-12-31-13-11-27/h1-7,14,23,29H,8-13,15-19H2,(H,26,30)
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337030
PNG
(US9745291, Compound 76 | US9765068, Compound 76)
Show SMILES C[C@H](Oc1cccc2cccnc12)C(=O)NC[C@H](O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H27N3O3/c1-17(30-22-10-4-8-19-9-5-12-25-23(19)22)24(29)26-14-21(28)16-27-13-11-18-6-2-3-7-20(18)15-27/h2-10,12,17,21,28H,11,13-16H2,1H3,(H,26,29)/t17-,21-/m0/s1
PDB

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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337031
PNG
(US9745291, Compound 77 | US9765068, Compound 77)
Show SMILES O[C@@H](CNC(=O)COc1ccccc1N1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O4/c28-21(17-26-10-9-19-5-1-2-6-20(19)16-26)15-25-24(29)18-31-23-8-4-3-7-22(23)27-11-13-30-14-12-27/h1-8,21,28H,9-18H2,(H,25,29)/t21-/m0/s1
PDB

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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337033
PNG
(US9745291, Compound 79 | US9765068, Compound 79)
Show SMILES OC(CNC(=O)COc1ccccc1N1CCNCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H32N4O3/c29-21(17-27-12-9-19-5-1-2-6-20(19)16-27)15-26-24(30)18-31-23-8-4-3-7-22(23)28-13-10-25-11-14-28/h1-8,21,25,29H,9-18H2,(H,26,30)
PDB

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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337034
PNG
(US9745291, Compound 80 | US9765068, Compound 80)
Show SMILES CN1C(=O)COc2cccc(OCC(=O)NCC(O)CN3CCc4ccccc4C3)c12
Show InChI InChI=1S/C23H27N3O5/c1-25-22(29)15-31-20-8-4-7-19(23(20)25)30-14-21(28)24-11-18(27)13-26-10-9-16-5-2-3-6-17(16)12-26/h2-8,18,27H,9-15H2,1H3,(H,24,28)
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337035
PNG
(US9745291, Compound 81 | US9765068, Compound 81)
Show SMILES CN1CCOc2cccc(OCC(=O)NCC(O)CN3CCc4ccccc4C3)c12
Show InChI InChI=1S/C23H29N3O4/c1-25-11-12-29-20-7-4-8-21(23(20)25)30-16-22(28)24-13-19(27)15-26-10-9-17-5-2-3-6-18(17)14-26/h2-8,19,27H,9-16H2,1H3,(H,24,28)
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337036
PNG
(US9745291, Compound 82 | US9765068, Compound 82)
Show SMILES Cn1ncc2c(OCC(=O)NCC(O)CN3CCc4ccccc4C3)cccc12
Show InChI InChI=1S/C22H26N4O3/c1-25-20-7-4-8-21(19(20)12-24-25)29-15-22(28)23-11-18(27)14-26-10-9-16-5-2-3-6-17(16)13-26/h2-8,12,18,27H,9-11,13-15H2,1H3,(H,23,28)
PDB

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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337038
PNG
(US9745291, Compound 84 | US9765068, Compound 84)
Show SMILES CN1CCN(CC1)c1ccccc1OCC(=O)NC[C@H](O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H34N4O3/c1-27-12-14-29(15-13-27)23-8-4-5-9-24(23)32-19-25(31)26-16-22(30)18-28-11-10-20-6-2-3-7-21(20)17-28/h2-9,22,30H,10-19H2,1H3,(H,26,31)/t22-/m0/s1
PDB

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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337040
PNG
(US9745291, Compound 86 | US9765068, Compound 86)
Show SMILES O[C@@H](CNC(=O)COc1ccccc1OCCN1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C26H35N3O5/c30-23(19-29-10-9-21-5-1-2-6-22(21)18-29)17-27-26(31)20-34-25-8-4-3-7-24(25)33-16-13-28-11-14-32-15-12-28/h1-8,23,30H,9-20H2,(H,27,31)/t23-/m0/s1
PDB

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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337042
PNG
(US9745291, Compound 88 | US9765068, Compound 88)
Show SMILES CN(C)CCOc1ccccc1OCC(=O)NC[C@H](O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H33N3O4/c1-26(2)13-14-30-22-9-5-6-10-23(22)31-18-24(29)25-15-21(28)17-27-12-11-19-7-3-4-8-20(19)16-27/h3-10,21,28H,11-18H2,1-2H3,(H,25,29)/t21-/m0/s1
PDB

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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337044
PNG
(US9745291, Compound 90 | US9765068, Compound 90)
Show SMILES CC(=O)N1CCN(CC1)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C26H34N4O4/c1-20(31)29-12-14-30(15-13-29)24-8-4-5-9-25(24)34-19-26(33)27-16-23(32)18-28-11-10-21-6-2-3-7-22(21)17-28/h2-9,23,32H,10-19H2,1H3,(H,27,33)
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337045
PNG
(US9745291, Compound 91 | US9765068, Compound 91)
Show SMILES OC(CNC(=O)COc1cccc2CNCCc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H29N3O3/c27-20(15-26-11-9-17-4-1-2-5-19(17)14-26)13-25-23(28)16-29-22-7-3-6-18-12-24-10-8-21(18)22/h1-7,20,24,27H,8-16H2,(H,25,28)
PDB

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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337046
PNG
(US9745291, Compound 92 | US9765068, Compound 92)
Show SMILES OC(CNC(=O)COc1cccc2nccnc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H24N4O3/c27-18(14-26-11-8-16-4-1-2-5-17(16)13-26)12-25-21(28)15-29-20-7-3-6-19-22(20)24-10-9-23-19/h1-7,9-10,18,27H,8,11-15H2,(H,25,28)
PDB

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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337047
PNG
(US9745291, Compound 93 | US9765068, Compound 93)
Show SMILES OC(CNC(=O)COc1cccc(NC2CCOCC2)c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H33N3O4/c29-23(17-28-11-8-19-4-1-2-5-20(19)16-28)15-26-25(30)18-32-24-7-3-6-22(14-24)27-21-9-12-31-13-10-21/h1-7,14,21,23,27,29H,8-13,15-18H2,(H,26,30)
PDB

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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337048
PNG
(US9745291, Compound 94 | US9765068, Compound 94)
Show SMILES O[C@@H](CNC(=O)COc1c(CN2CCOCC2)ccc2cccnc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C28H34N4O4/c33-25(19-32-11-9-21-4-1-2-5-23(21)17-32)16-30-26(34)20-36-28-24(18-31-12-14-35-15-13-31)8-7-22-6-3-10-29-27(22)28/h1-8,10,25,33H,9,11-20H2,(H,30,34)/t25-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337049
PNG
(US9745291, Compound 95 | US9765068, Compound 95)
Show SMILES OC(CNC(=O)COc1ccc2n(ncc2c1)C1CCNC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H31N5O3/c31-22(16-29-10-8-18-3-1-2-4-19(18)15-29)14-27-25(32)17-33-23-5-6-24-20(11-23)12-28-30(24)21-7-9-26-13-21/h1-6,11-12,21-22,26,31H,7-10,13-17H2,(H,27,32)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337050
PNG
(US9745291, Compound 96 | US9765068, Compound 96)
Show SMILES CN1CCC(C1)n1ncc2cc(OCC(=O)NCC(O)CN3CCc4ccccc4C3)ccc12
Show InChI InChI=1S/C26H33N5O3/c1-29-10-9-22(16-29)31-25-7-6-24(12-21(25)13-28-31)34-18-26(33)27-14-23(32)17-30-11-8-19-4-2-3-5-20(19)15-30/h2-7,12-13,22-23,32H,8-11,14-18H2,1H3,(H,27,33)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337052
PNG
(US9745291, Compound 98 | US9765068, Compound 98)
Show SMILES COc1ccc2cccc(OCC(=O)NC[C@@H](O)CN3CCc4ccccc4C3)c2n1
Show InChI InChI=1S/C24H27N3O4/c1-30-23-10-9-18-7-4-8-21(24(18)26-23)31-16-22(29)25-13-20(28)15-27-12-11-17-5-2-3-6-19(17)14-27/h2-10,20,28H,11-16H2,1H3,(H,25,29)/t20-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337053
PNG
(US9745291, Compound 99 | US9765068, Compound 99)
Show SMILES CN1CCc2c(C1)cccc2OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O3/c1-26-11-10-22-20(14-26)7-4-8-23(22)30-17-24(29)25-13-21(28)16-27-12-9-18-5-2-3-6-19(18)15-27/h2-8,21,28H,9-17H2,1H3,(H,25,29)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337054
PNG
(US9745291, Compound 100 | US9765068, Compound 100)
Show SMILES OC(CNC(=O)COc1cccc2OCCOc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H26N2O5/c25-18(14-24-9-8-16-4-1-2-5-17(16)13-24)12-23-21(26)15-29-20-7-3-6-19-22(20)28-11-10-27-19/h1-7,18,25H,8-15H2,(H,23,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337055
PNG
(US9745291, Compound 101 | US9765068, Compound 101)
Show SMILES CC(=O)N1CCc2c(C1)cccc2OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H31N3O4/c1-18(29)28-12-10-23-21(15-28)7-4-8-24(23)32-17-25(31)26-13-22(30)16-27-11-9-19-5-2-3-6-20(19)14-27/h2-8,22,30H,9-17H2,1H3,(H,26,31)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337056
PNG
(US9745291, Compound 102 | US9765068, Compound 102)
Show SMILES CS(=O)(=O)N1CCc2c(C1)cccc2OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O5S/c1-33(30,31)27-12-10-22-20(15-27)7-4-8-23(22)32-17-24(29)25-13-21(28)16-26-11-9-18-5-2-3-6-19(18)14-26/h2-8,21,28H,9-17H2,1H3,(H,25,29)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337057
PNG
(US9745291, Compound 103 | US9765068, Compound 103)
Show SMILES OC(CNC(=O)COc1ccccc1C1CCNCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H33N3O3/c29-22(17-28-14-11-19-5-1-2-6-21(19)16-28)15-27-25(30)18-31-24-8-4-3-7-23(24)20-9-12-26-13-10-20/h1-8,20,22,26,29H,9-18H2,(H,27,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337059
PNG
(US9745291, Compound 105 | US9765068, Compound 105)
Show SMILES CN(C)c1ccc2cccc(OCC(=O)NC[C@@H](O)CN3CCc4ccccc4C3)c2n1
Show InChI InChI=1S/C25H30N4O3/c1-28(2)23-11-10-19-8-5-9-22(25(19)27-23)32-17-24(31)26-14-21(30)16-29-13-12-18-6-3-4-7-20(18)15-29/h3-11,21,30H,12-17H2,1-2H3,(H,26,31)/t21-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337061
PNG
(US9745291, Compound 107 | US9765068, Compound 107)
Show SMILES OC(CNC(=O)COc1ccccc1S(=O)(=O)N1CCNCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H32N4O5S/c29-21(17-27-12-9-19-5-1-2-6-20(19)16-27)15-26-24(30)18-33-22-7-3-4-8-23(22)34(31,32)28-13-10-25-11-14-28/h1-8,21,25,29H,9-18H2,(H,26,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337062
PNG
(US9745291, Compound 108 | US9765068, Compound 108)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H34N4O5S/c1-27-12-14-29(15-13-27)35(32,33)24-9-5-4-8-23(24)34-19-25(31)26-16-22(30)18-28-11-10-20-6-2-3-7-21(20)17-28/h2-9,22,30H,10-19H2,1H3,(H,26,31)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337063
PNG
(US9745291, Compound 109 | US9765068, Compound 109)
Show SMILES CN(C)S(=O)(=O)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H29N3O5S/c1-24(2)31(28,29)21-10-6-5-9-20(21)30-16-22(27)23-13-19(26)15-25-12-11-17-7-3-4-8-18(17)14-25/h3-10,19,26H,11-16H2,1-2H3,(H,23,27)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337064
PNG
(US9745291, Compound 110 | US9765068, Compound 110)
Show SMILES OC(CNC(=O)COc1ccccc1S(=O)(=O)N1CCCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O5S/c28-21(17-26-14-11-19-7-1-2-8-20(19)16-26)15-25-24(29)18-32-22-9-3-4-10-23(22)33(30,31)27-12-5-6-13-27/h1-4,7-10,21,28H,5-6,11-18H2,(H,25,29)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337065
PNG
(US9745291, Compound 111 | US9765068, Compound 111)
Show SMILES OC(CNC(=O)COc1ccccc1S(=O)(=O)N1CCC(O)C1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O6S/c28-20-10-12-27(16-20)34(31,32)23-8-4-3-7-22(23)33-17-24(30)25-13-21(29)15-26-11-9-18-5-1-2-6-19(18)14-26/h1-8,20-21,28-29H,9-17H2,(H,25,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297725
PNG
((S)No FitN-(2-hydroxy-3-(isoindolin-2-yl)propyl)-2...)
Show SMILES O[C@@H](CNC(=O)COc1cccc2cccnc12)CN1Cc2ccccc2C1
Show InChI InChI=1S/C22H23N3O3/c26-19(14-25-12-17-5-1-2-6-18(17)13-25)11-24-21(27)15-28-20-9-3-7-16-8-4-10-23-22(16)20/h1-10,19,26H,11-15H2,(H,24,27)/t19-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10118918 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297726
PNG
((R)No FitNNo Fit((S)-2-hydroxy-3-(isoindolin-2-yl)...)
Show SMILES C[C@@H](Oc1cccc2cccnc12)C(=O)NC[C@H](O)CN1Cc2ccccc2C1
Show InChI InChI=1S/C23H25N3O3/c1-16(29-21-10-4-8-17-9-5-11-24-22(17)21)23(28)25-12-20(27)15-26-13-18-6-2-3-7-19(18)14-26/h2-11,16,20,27H,12-15H2,1H3,(H,25,28)/t16-,20+/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10118918 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297736
PNG
(2-(2-(N,N-dimethylsulfamoyl)phenoxy)-N-(2-hydroxy-...)
Show SMILES CN(C)S(=O)(=O)c1ccccc1OCC(=O)NCC(O)CN1Cc2ccccc2C1
Show InChI InChI=1S/C21H27N3O5S/c1-23(2)30(27,28)20-10-6-5-9-19(20)29-15-21(26)22-11-18(25)14-24-12-16-7-3-4-8-17(16)13-24/h3-10,18,25H,11-15H2,1-2H3,(H,22,26)
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10118918 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297744
PNG
(US10118918, Compound 23 | US9732072, Compound 23)
Show SMILES CN(C)S(=O)(=O)c1ccccc1OCC(=O)NC[C@H](O)CN1Cc2ccccc2C1
Show InChI InChI=1S/C21H27N3O5S/c1-23(2)30(27,28)20-10-6-5-9-19(20)29-15-21(26)22-11-18(25)14-24-12-16-7-3-4-8-17(16)13-24/h3-10,18,25H,11-15H2,1-2H3,(H,22,26)/t18-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10118918 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297745
PNG
(US10118918, Compound 24 | US9732072, Compound 24)
Show SMILES O[C@H](CNC(=O)c1cccc(NC2CCOCC2)c1)CN1Cc2ccccc2C1
Show InChI InChI=1S/C23H29N3O3/c27-22(16-26-14-18-4-1-2-5-19(18)15-26)13-24-23(28)17-6-3-7-21(12-17)25-20-8-10-29-11-9-20/h1-7,12,20,22,25,27H,8-11,13-16H2,(H,24,28)/t22-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10118918 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297749
PNG
(US10118918, Compound 28 | US9732072, Compound 28)
Show SMILES O[C@@H](CNC(=O)c1cccc(NC2CCOCC2)c1)CN1Cc2ccccc2C1
Show InChI InChI=1S/C23H29N3O3/c27-22(16-26-14-18-4-1-2-5-19(18)15-26)13-24-23(28)17-6-3-7-21(12-17)25-20-8-10-29-11-9-20/h1-7,12,20,22,25,27H,8-11,13-16H2,(H,24,28)/t22-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10118918 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297750
PNG
(US10118918, Compound 29 | US9732072, Compound 29)
Show SMILES O[C@@H](CNC(=O)c1cc(NC2CCOCC2)ncn1)CN1Cc2ccccc2C1
Show InChI InChI=1S/C21H27N5O3/c27-18(13-26-11-15-3-1-2-4-16(15)12-26)10-22-21(28)19-9-20(24-14-23-19)25-17-5-7-29-8-6-17/h1-4,9,14,17-18,27H,5-8,10-13H2,(H,22,28)(H,23,24,25)/t18-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10118918 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297751
PNG
(US10118918, Compound 30 | US9732072, Compound 30)
Show SMILES O[C@@H](CNC(=O)c1ccnc(NC2CCOCC2)c1)CN1Cc2ccccc2C1
Show InChI InChI=1S/C22H28N4O3/c27-20(15-26-13-17-3-1-2-4-18(17)14-26)12-24-22(28)16-5-8-23-21(11-16)25-19-6-9-29-10-7-19/h1-5,8,11,19-20,27H,6-7,9-10,12-15H2,(H,23,25)(H,24,28)/t20-/m0/s1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10118918 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297756
PNG
(US10118918, Compound 38)
Show SMILES O[C@@H](CNC(=O)c1cc(NC2COC2)nc(n1)N1CCOCC1)CN1Cc2ccccc2C1
Show InChI InChI=1S/C23H30N6O4/c30-19(13-28-11-16-3-1-2-4-17(16)12-28)10-24-22(31)20-9-21(25-18-14-33-15-18)27-23(26-20)29-5-7-32-8-6-29/h1-4,9,18-19,30H,5-8,10-15H2,(H,24,31)(H,25,26,27)/t19-/m0/s1
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US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10118918 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297757
PNG
(US10118918, Compound 39)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc(ncn1)C(=O)NC[C@H](O)CN1Cc2ccccc2C1
Show InChI InChI=1S/C23H30N6O3/c1-16(30)29-8-6-19(7-9-29)27-22-10-21(25-15-26-22)23(32)24-11-20(31)14-28-12-17-4-2-3-5-18(17)13-28/h2-5,10,15,19-20,31H,6-9,11-14H2,1H3,(H,24,32)(H,25,26,27)/t20-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10118918 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297758
PNG
(US10118918, Compound 40)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc(ccn1)C(=O)NC[C@H](O)CN1Cc2ccccc2C1
Show InChI InChI=1S/C24H31N5O3/c1-17(30)29-10-7-21(8-11-29)27-23-12-18(6-9-25-23)24(32)26-13-22(31)16-28-14-19-4-2-3-5-20(19)15-28/h2-6,9,12,21-22,31H,7-8,10-11,13-16H2,1H3,(H,25,27)(H,26,32)/t22-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10118918 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM310188
PNG
(1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypr...)
Show SMILES OC(CN1CCc2ccccc2C1)CN1CCN(CC1=O)c1cccc2cccnc12
Show InChI InChI=1S/C25H28N4O2/c30-22(16-27-12-10-19-5-1-2-6-21(19)15-27)17-29-14-13-28(18-24(29)31)23-9-3-7-20-8-4-11-26-25(20)23/h1-9,11,22,30H,10,12-18H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
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US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10150758 (2018)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM310189
PNG
(4-(3-chlorophenyl)-1-(3-(3,4-dihydroisoquinolin-2(...)
Show SMILES OC(CN1CCc2ccccc2C1)CN1CCN(CC1=O)c1cccc(Cl)c1
Show InChI InChI=1S/C22H26ClN3O2/c23-19-6-3-7-20(12-19)25-10-11-26(22(28)16-25)15-21(27)14-24-9-8-17-4-1-2-5-18(17)13-24/h1-7,12,21,27H,8-11,13-16H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10150758 (2018)

More data for this
Ligand-Target Pair
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