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Compile Data Set for Download or QSAR

Found 130 hits of kd data for polymerid = 3429,49000056,7884   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50407992
PNG
(CHEMBL148346)
Show SMILES Cc1coc2cc3N(CCc3cc12)C(=O)Nc1cccnc1
Show InChI InChI=1S/C17H15N3O2/c1-11-10-22-16-8-15-12(7-14(11)16)4-6-20(15)17(21)19-13-3-2-5-18-9-13/h2-3,5,7-10H,4,6H2,1H3,(H,19,21)
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n/an/an/a 1.26n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus


J Med Chem 39: 4966-77 (1997)


Article DOI: 10.1021/jm960571v
BindingDB Entry DOI: 10.7270/Q2S75HJF
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50060417
PNG
(5-Methyl-3,5-dihydro-2H-pyrrolo[2,3-f]indole-1-car...)
Show SMILES Cn1ccc2cc3N(CCc3cc12)C(=O)Nc1cccnc1
Show InChI InChI=1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22)
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n/an/an/a 3.16n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus


J Med Chem 39: 4966-77 (1997)


Article DOI: 10.1021/jm960571v
BindingDB Entry DOI: 10.7270/Q2S75HJF
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50060417
PNG
(5-Methyl-3,5-dihydro-2H-pyrrolo[2,3-f]indole-1-car...)
Show SMILES Cn1ccc2cc3N(CCc3cc12)C(=O)Nc1cccnc1
Show InChI InChI=1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22)
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n/an/an/a 3.31n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor


J Med Chem 38: 2524-30 (1995)


Article DOI: 10.1021/jm00014a004
BindingDB Entry DOI: 10.7270/Q2MP54HC
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50408003
PNG
(CHEMBL148347)
Show SMILES Cc1cn(C)c2cc3CCN(C(=O)Nc4ccccc4)c3cc12
Show InChI InChI=1S/C19H19N3O/c1-13-12-21(2)18-10-14-8-9-22(17(14)11-16(13)18)19(23)20-15-6-4-3-5-7-15/h3-7,10-12H,8-9H2,1-2H3,(H,20,23)
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n/an/an/a 6.31n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus


J Med Chem 39: 4966-77 (1997)


Article DOI: 10.1021/jm960571v
BindingDB Entry DOI: 10.7270/Q2S75HJF
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50408001
PNG
(CHEMBL147820)
Show SMILES CC(C)n1ccc2cc3N(CCc3cc12)C(=O)Nc1cccnc1
Show InChI InChI=1S/C19H20N4O/c1-13(2)22-8-5-14-11-18-15(10-17(14)22)6-9-23(18)19(24)21-16-4-3-7-20-12-16/h3-5,7-8,10-13H,6,9H2,1-2H3,(H,21,24)
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n/an/an/a 6.31n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus


J Med Chem 39: 4966-77 (1997)


Article DOI: 10.1021/jm960571v
BindingDB Entry DOI: 10.7270/Q2S75HJF
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50407997
PNG
(CHEMBL2112859)
Show SMILES CCCn1ccc2cc3N(CCc3cc12)C(=O)Nc1cccnc1
Show InChI InChI=1S/C19H20N4O/c1-2-8-22-9-5-14-12-18-15(11-17(14)22)6-10-23(18)19(24)21-16-4-3-7-20-13-16/h3-5,7,9,11-13H,2,6,8,10H2,1H3,(H,21,24)
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n/an/an/a 7.94n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus


J Med Chem 39: 4966-77 (1997)


Article DOI: 10.1021/jm960571v
BindingDB Entry DOI: 10.7270/Q2S75HJF
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50407993
PNG
(CHEMBL148385)
Show SMILES CCn1ccc2cc3N(CCc3cc12)C(=O)Nc1cccnc1
Show InChI InChI=1S/C18H18N4O/c1-2-21-8-5-13-11-17-14(10-16(13)21)6-9-22(17)18(23)20-15-4-3-7-19-12-15/h3-5,7-8,10-12H,2,6,9H2,1H3,(H,20,23)
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n/an/an/a 10n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus


J Med Chem 39: 4966-77 (1997)


Article DOI: 10.1021/jm960571v
BindingDB Entry DOI: 10.7270/Q2S75HJF
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50407991
PNG
(CHEMBL343666)
Show SMILES O=C(Nc1cccnc1)N1CCc2cc3sccc3cc12
Show InChI InChI=1S/C16H13N3OS/c20-16(18-13-2-1-5-17-10-13)19-6-3-11-9-15-12(4-7-21-15)8-14(11)19/h1-2,4-5,7-10H,3,6H2,(H,18,20)
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n/an/an/a 10n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus


J Med Chem 39: 4966-77 (1997)


Article DOI: 10.1021/jm960571v
BindingDB Entry DOI: 10.7270/Q2S75HJF
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM84991
PNG
(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
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n/an/an/a 11.2n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus


J Med Chem 38: 855-7 (1995)


Article DOI: 10.1021/jm00006a001
BindingDB Entry DOI: 10.7270/Q22N53G6
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50404646
PNG
(CHEMBL177800)
Show SMILES COc1cc(C)c(O)cc1CC(C)N
Show InChI InChI=1S/C11H17NO2/c1-7-4-11(14-3)9(5-8(2)12)6-10(7)13/h4,6,8,13H,5,12H2,1-3H3
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n/an/an/a 12.3n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation


J Med Chem 23: 990-4 (1980)


Article DOI: 10.1021/jm00183a006
BindingDB Entry DOI: 10.7270/Q2668FCW
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50407998
PNG
(CHEMBL144567)
Show SMILES CN1CCc2cc3N(CCc3cc12)C(=O)Nc1cccnc1
Show InChI InChI=1S/C17H18N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-3,6,9-11H,4-5,7-8H2,1H3,(H,19,22)
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n/an/an/a 12.6n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus


J Med Chem 39: 4966-77 (1997)


Article DOI: 10.1021/jm960571v
BindingDB Entry DOI: 10.7270/Q2S75HJF
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50407722
PNG
(CHEMBL172269)
Show SMILES Cc1cc(NC(=O)Nc2ccc3sccc3c2)sn1
Show InChI InChI=1S/C13H11N3OS2/c1-8-6-12(19-16-8)15-13(17)14-10-2-3-11-9(7-10)4-5-18-11/h2-7H,1H3,(H2,14,15,17)
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n/an/an/a 15.1n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus


J Med Chem 38: 855-7 (1995)


Article DOI: 10.1021/jm00006a001
BindingDB Entry DOI: 10.7270/Q22N53G6
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50407399
PNG
(CHEMBL315223)
Show SMILES Cn1ccc2c3CCN(C(=O)Nc4cccnc4)c3ccc12
Show InChI InChI=1S/C17H16N4O/c1-20-9-6-13-14-7-10-21(16(14)5-4-15(13)20)17(22)19-12-3-2-8-18-11-12/h2-6,8-9,11H,7,10H2,1H3,(H,19,22)
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n/an/an/a 15.8n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus


J Med Chem 39: 4966-77 (1997)


Article DOI: 10.1021/jm960571v
BindingDB Entry DOI: 10.7270/Q2S75HJF
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50407399
PNG
(CHEMBL315223)
Show SMILES Cn1ccc2c3CCN(C(=O)Nc4cccnc4)c3ccc12
Show InChI InChI=1S/C17H16N4O/c1-20-9-6-13-14-7-10-21(16(14)5-4-15(13)20)17(22)19-12-3-2-8-18-11-12/h2-6,8-9,11H,7,10H2,1H3,(H,19,22)
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n/an/an/a 17.8n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor


J Med Chem 38: 2524-30 (1995)


Article DOI: 10.1021/jm00014a004
BindingDB Entry DOI: 10.7270/Q2MP54HC
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50407994
PNG
(CHEMBL343455)
Show SMILES Cc1cc2cc3N(CCc3cc2n1C)C(=O)Nc1cccnc1
Show InChI InChI=1S/C18H18N4O/c1-12-8-14-10-17-13(9-16(14)21(12)2)5-7-22(17)18(23)20-15-4-3-6-19-11-15/h3-4,6,8-11H,5,7H2,1-2H3,(H,20,23)
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n/an/an/a 19.9n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus


J Med Chem 39: 4966-77 (1997)


Article DOI: 10.1021/jm960571v
BindingDB Entry DOI: 10.7270/Q2S75HJF
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50408000
PNG
(CHEMBL357870)
Show SMILES O=C(Nc1cccnc1)N1CCc2cc3[nH]ccc3cc12
Show InChI InChI=1S/C16H14N4O/c21-16(19-13-2-1-5-17-10-13)20-7-4-12-8-14-11(3-6-18-14)9-15(12)20/h1-3,5-6,8-10,18H,4,7H2,(H,19,21)
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n/an/an/a 31.6n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus


J Med Chem 39: 4966-77 (1997)


Article DOI: 10.1021/jm960571v
BindingDB Entry DOI: 10.7270/Q2S75HJF
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50409491
PNG
(CHEMBL95098)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN(CCC2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C25H29FN2O2/c26-22-9-7-19(8-10-22)24(29)6-3-12-27-14-16-28(17-15-27)13-11-21-18-20-4-1-2-5-23(20)25(21)30/h1-2,4-5,7-10,21H,3,6,11-18H2
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n/an/an/a 31.6n/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus


J Med Chem 45: 54-71 (2001)


Article DOI: 10.1021/jm011014y
BindingDB Entry DOI: 10.7270/Q2KD204K
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50404644
PNG
(CHEMBL174380)
Show SMILES COc1cc(CC(C)N)c(O)cc1C
Show InChI InChI=1S/C11H17NO2/c1-7-4-10(13)9(5-8(2)12)6-11(7)14-3/h4,6,8,13H,5,12H2,1-3H3
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n/an/an/a 36.3n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation


J Med Chem 23: 990-4 (1980)


Article DOI: 10.1021/jm00183a006
BindingDB Entry DOI: 10.7270/Q2668FCW
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM82272
PNG
(SB 200646 | SB200646a)
Show SMILES Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc12
Show InChI InChI=1S/C15H14N4O/c1-19-8-6-11-9-12(4-5-14(11)19)17-15(20)18-13-3-2-7-16-10-13/h2-10H,1H3,(H2,17,18,20)
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n/an/an/a 38.9n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus


J Med Chem 38: 855-7 (1995)


Article DOI: 10.1021/jm00006a001
BindingDB Entry DOI: 10.7270/Q22N53G6
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM82272
PNG
(SB 200646 | SB200646a)
Show SMILES Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc12
Show InChI InChI=1S/C15H14N4O/c1-19-8-6-11-9-12(4-5-14(11)19)17-15(20)18-13-3-2-7-16-10-13/h2-10H,1H3,(H2,17,18,20)
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n/an/an/a 39.8n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor


J Med Chem 38: 2524-30 (1995)


Article DOI: 10.1021/jm00014a004
BindingDB Entry DOI: 10.7270/Q2MP54HC
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50409488
PNG
(CHEMBL87026)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCC2CCCc3ccccc3C2=O)CC1
Show InChI InChI=1S/C25H28FNO2/c26-22-10-8-20(9-11-22)24(28)21-13-16-27(17-14-21)15-12-19-6-3-5-18-4-1-2-7-23(18)25(19)29/h1-2,4,7-11,19,21H,3,5-6,12-17H2
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n/an/an/a 39.8n/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus


J Med Chem 45: 54-71 (2001)


Article DOI: 10.1021/jm011014y
BindingDB Entry DOI: 10.7270/Q2KD204K
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50005257
PNG
((+)-2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethy...)
Show SMILES COc1cc(CC(C)N)c(OC)cc1Br
Show InChI InChI=1S/C11H16BrNO2/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2/h5-7H,4,13H2,1-3H3
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n/an/an/a 44.7n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus


J Med Chem 24: 1414-21 (1982)


Article DOI: 10.1021/jm00144a009
BindingDB Entry DOI: 10.7270/Q2SX6FD3
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50407723
PNG
(CHEMBL354951)
Show SMILES Cc1cc(NC(=O)Nc2ccc3sccc3c2)on1
Show InChI InChI=1S/C13H11N3O2S/c1-8-6-12(18-16-8)15-13(17)14-10-2-3-11-9(7-10)4-5-19-11/h2-7H,1H3,(H2,14,15,17)
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n/an/an/a 46.8n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus


J Med Chem 38: 855-7 (1995)


Article DOI: 10.1021/jm00006a001
BindingDB Entry DOI: 10.7270/Q22N53G6
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50407400
PNG
(CHEMBL84888)
Show SMILES Cn1ccc2cc3N(CCCc3cc12)C(=O)Nc1cccnc1
Show InChI InChI=1S/C18H18N4O/c1-21-9-6-14-11-17-13(10-16(14)21)4-3-8-22(17)18(23)20-15-5-2-7-19-12-15/h2,5-7,9-12H,3-4,8H2,1H3,(H,20,23)
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n/an/an/a 53.7n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor


J Med Chem 38: 2524-30 (1995)


Article DOI: 10.1021/jm00014a004
BindingDB Entry DOI: 10.7270/Q2MP54HC
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50407401
PNG
(CHEMBL85247)
Show SMILES Cn1ccc2c3CCCN(C(=O)Nc4cccnc4)c3ccc12
Show InChI InChI=1S/C18H18N4O/c1-21-11-8-15-14-5-3-10-22(17(14)7-6-16(15)21)18(23)20-13-4-2-9-19-12-13/h2,4,6-9,11-12H,3,5,10H2,1H3,(H,20,23)
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n/an/an/a 60.3n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor


J Med Chem 38: 2524-30 (1995)


Article DOI: 10.1021/jm00014a004
BindingDB Entry DOI: 10.7270/Q2MP54HC
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50403684
PNG
(CHEMBL120903)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC2Cc3[nH]c4ccccc4c3C(=O)C2)CC1
Show InChI InChI=1S/C25H25FN2O2/c26-19-7-5-17(6-8-19)25(30)18-9-11-28(12-10-18)15-16-13-22-24(23(29)14-16)20-3-1-2-4-21(20)27-22/h1-8,16,18,27H,9-15H2
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n/an/an/a 60.3n/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus


J Med Chem 45: 54-71 (2001)


Article DOI: 10.1021/jm011014y
BindingDB Entry DOI: 10.7270/Q2KD204K
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50409510
PNG
(CHEMBL308480)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC2CC(=O)c3ccccc3C2)CC1
Show InChI InChI=1S/C23H24FNO2/c24-20-7-5-17(6-8-20)23(27)18-9-11-25(12-10-18)15-16-13-19-3-1-2-4-21(19)22(26)14-16/h1-8,16,18H,9-15H2
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n/an/an/a 63.1n/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus


J Med Chem 45: 54-71 (2001)


Article DOI: 10.1021/jm011014y
BindingDB Entry DOI: 10.7270/Q2KD204K
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50409508
PNG
(CHEMBL110847)
Show SMILES COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1
Show InChI InChI=1S/C21H26N2O2S/c1-25-19-5-3-2-4-18(19)23-13-11-22(12-14-23)10-8-16-6-7-20-17(21(16)24)9-15-26-20/h2-5,9,15-16H,6-8,10-14H2,1H3
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n/an/an/a 64.6n/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus


J Med Chem 45: 54-71 (2001)


Article DOI: 10.1021/jm011014y
BindingDB Entry DOI: 10.7270/Q2KD204K
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50407721
PNG
(CHEMBL422923)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)on1
Show InChI InChI=1S/C14H14N4O2/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
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n/an/an/a 69.2n/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus


J Med Chem 38: 855-7 (1995)


Article DOI: 10.1021/jm00006a001
BindingDB Entry DOI: 10.7270/Q22N53G6
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50409509
PNG
(CHEMBL87943)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCC2CCc3ccccc3C2=O)CC1
Show InChI InChI=1S/C24H26FNO2/c25-21-9-7-18(8-10-21)23(27)20-12-15-26(16-13-20)14-11-19-6-5-17-3-1-2-4-22(17)24(19)28/h1-4,7-10,19-20H,5-6,11-16H2
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n/an/an/a 70.8n/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus


J Med Chem 45: 54-71 (2001)


Article DOI: 10.1021/jm011014y
BindingDB Entry DOI: 10.7270/Q2KD204K
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50409521
PNG
(CHEMBL92145)
Show SMILES COc1ccccc1N1CCN(CCC2CCc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H28N2O2/c1-27-22-9-5-4-8-21(22)25-16-14-24(15-17-25)13-12-19-11-10-18-6-2-3-7-20(18)23(19)26/h2-9,19H,10-17H2,1H3
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n/an/an/a 74.1n/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus


J Med Chem 45: 54-71 (2001)


Article DOI: 10.1021/jm011014y
BindingDB Entry DOI: 10.7270/Q2KD204K
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50005265
PNG
((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...)
Show SMILES COc1cc(CC(C)N)c(OC)cc1C
Show InChI InChI=1S/C12H19NO2/c1-8-5-12(15-4)10(6-9(2)13)7-11(8)14-3/h5,7,9H,6,13H2,1-4H3
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n/an/an/a 75.9n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus


J Med Chem 24: 1414-21 (1982)


Article DOI: 10.1021/jm00144a009
BindingDB Entry DOI: 10.7270/Q2SX6FD3
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50404646
PNG
(CHEMBL177800)
Show SMILES COc1cc(C)c(O)cc1CC(C)N
Show InChI InChI=1S/C11H17NO2/c1-7-4-11(14-3)9(5-8(2)12)6-10(7)13/h4,6,8,13H,5,12H2,1-3H3
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n/an/an/a 76n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic against 5-hydroxytryptamine 2B receptor


J Med Chem 23: 990-4 (1980)


Article DOI: 10.1021/jm00183a006
BindingDB Entry DOI: 10.7270/Q2668FCW
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50404644
PNG
(CHEMBL174380)
Show SMILES COc1cc(CC(C)N)c(O)cc1C
Show InChI InChI=1S/C11H17NO2/c1-7-4-10(13)9(5-8(2)12)6-11(7)14-3/h4,6,8,13H,5,12H2,1-3H3
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n/an/an/a 76n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic against 5-hydroxytryptamine 2B receptor


J Med Chem 23: 990-4 (1980)


Article DOI: 10.1021/jm00183a006
BindingDB Entry DOI: 10.7270/Q2668FCW
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50404640
PNG
(CHEMBL175204)
Show SMILES COc1ccc(O)c(CCN)c1
Show InChI InChI=1S/C9H13NO2/c1-12-8-2-3-9(11)7(6-8)4-5-10/h2-3,6,11H,4-5,10H2,1H3
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n/an/an/a 79.4n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation


J Med Chem 23: 990-4 (1980)


Article DOI: 10.1021/jm00183a006
BindingDB Entry DOI: 10.7270/Q2668FCW
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM30707
PNG
(2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamin...)
Show SMILES COc1ccc2[nH]cc(CCN(C)C)c2c1
Show InChI InChI=1S/C13H18N2O/c1-15(2)7-6-10-9-14-13-5-4-11(16-3)8-12(10)13/h4-5,8-9,14H,6-7H2,1-3H3
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n/an/an/a 83.2n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus


J Med Chem 25: 68-70 (1982)


Article DOI: 10.1021/jm00343a013
BindingDB Entry DOI: 10.7270/Q2902507
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50409494
PNG
(CHEMBL159969)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCC2Cc3sccc3C2=O)CC1
Show InChI InChI=1S/C21H22FNO2S/c22-17-3-1-14(2-4-17)20(24)15-5-9-23(10-6-15)11-7-16-13-19-18(21(16)25)8-12-26-19/h1-4,8,12,15-16H,5-7,9-11,13H2
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n/an/an/a 87.1n/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus


J Med Chem 45: 54-71 (2001)


Article DOI: 10.1021/jm011014y
BindingDB Entry DOI: 10.7270/Q2KD204K
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50409513
PNG
(CHEMBL444269)
Show SMILES COc1ccccc1N1CCN(CC2CC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C21H24N2O2/c1-25-21-9-5-4-8-19(21)23-12-10-22(11-13-23)15-16-14-20(24)18-7-3-2-6-17(16)18/h2-9,16H,10-15H2,1H3
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n/an/an/a 91.2n/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus


J Med Chem 45: 54-71 (2001)


Article DOI: 10.1021/jm011014y
BindingDB Entry DOI: 10.7270/Q2KD204K
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50409498
PNG
(CHEMBL163180)
Show SMILES O=C1C(CCN2CCN(CC2)c2ccccn2)CCc2sccc12
Show InChI InChI=1S/C19H23N3OS/c23-19-15(4-5-17-16(19)7-14-24-17)6-9-21-10-12-22(13-11-21)18-3-1-2-8-20-18/h1-3,7-8,14-15H,4-6,9-13H2
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n/an/an/a 97.7n/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus


J Med Chem 45: 54-71 (2001)


Article DOI: 10.1021/jm011014y
BindingDB Entry DOI: 10.7270/Q2KD204K
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50404645
PNG
(CHEMBL175205)
Show SMILES COc1ccc(O)c(CC(C)N)c1
Show InChI InChI=1S/C10H15NO2/c1-7(11)5-8-6-9(13-2)3-4-10(8)12/h3-4,6-7,12H,5,11H2,1-2H3
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n/an/an/a 100n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation


J Med Chem 23: 990-4 (1980)


Article DOI: 10.1021/jm00183a006
BindingDB Entry DOI: 10.7270/Q2668FCW
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50409518
PNG
(CHEMBL349832)
Show SMILES CCc1c(C)[nH]c2CC(CN3CCN(CC3)c3ccccc3OC)CC(=O)c12
Show InChI InChI=1S/C23H31N3O2/c1-4-18-16(2)24-19-13-17(14-21(27)23(18)19)15-25-9-11-26(12-10-25)20-7-5-6-8-22(20)28-3/h5-8,17,24H,4,9-15H2,1-3H3
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n/an/an/a 126n/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus


J Med Chem 45: 54-71 (2001)


Article DOI: 10.1021/jm011014y
BindingDB Entry DOI: 10.7270/Q2KD204K
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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n/an/an/a 126n/an/an/an/an/a



Universidad de Santiago

Curated by ChEMBL


Assay Description
Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor


J Med Chem 43: 4678-93 (2001)


Article DOI: 10.1021/jm0009890
BindingDB Entry DOI: 10.7270/Q24B32H0
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50409506
PNG
(CHEMBL111393)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC2Cc3sccc3C(=O)C2)CC1
Show InChI InChI=1S/C21H22FNO2S/c22-17-3-1-15(2-4-17)21(25)16-5-8-23(9-6-16)13-14-11-19(24)18-7-10-26-20(18)12-14/h1-4,7,10,14,16H,5-6,8-9,11-13H2
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n/an/an/a 132n/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus


J Med Chem 45: 54-71 (2001)


Article DOI: 10.1021/jm011014y
BindingDB Entry DOI: 10.7270/Q2KD204K
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50404647
PNG
(CHEMBL174723)
Show SMILES COc1ccc(CC(C)N)cc1O
Show InChI InChI=1S/C10H15NO2/c1-7(11)5-8-3-4-10(13-2)9(12)6-8/h3-4,6-7,12H,5,11H2,1-2H3
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n/an/an/a 135n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation


J Med Chem 23: 990-4 (1980)


Article DOI: 10.1021/jm00183a006
BindingDB Entry DOI: 10.7270/Q2668FCW
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50404640
PNG
(CHEMBL175204)
Show SMILES COc1ccc(O)c(CCN)c1
Show InChI InChI=1S/C9H13NO2/c1-12-8-2-3-9(11)7(6-8)4-5-10/h2-3,6,11H,4-5,10H2,1H3
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n/an/an/a 141n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic against 5-hydroxytryptamine 2B receptor


J Med Chem 23: 990-4 (1980)


Article DOI: 10.1021/jm00183a006
BindingDB Entry DOI: 10.7270/Q2668FCW
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50404641
PNG
(CHEMBL174563)
Show SMILES COc1ccc(O)c(CCN(C)C)c1
Show InChI InChI=1S/C11H17NO2/c1-12(2)7-6-9-8-10(14-3)4-5-11(9)13/h4-5,8,13H,6-7H2,1-3H3
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n/an/an/a 145n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation


J Med Chem 23: 990-4 (1980)


Article DOI: 10.1021/jm00183a006
BindingDB Entry DOI: 10.7270/Q2668FCW
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50005251
PNG
((+/-)2-(2,5-Dimethoxy-phenyl)-1-methyl-ethylamine ...)
Show SMILES COc1ccc(OC)c(CC(C)N)c1
Show InChI InChI=1S/C11H17NO2/c1-8(12)6-9-7-10(13-2)4-5-11(9)14-3/h4-5,7-8H,6,12H2,1-3H3
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n/an/an/a 148n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus


J Med Chem 24: 1414-21 (1982)


Article DOI: 10.1021/jm00144a009
BindingDB Entry DOI: 10.7270/Q2SX6FD3
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50404645
PNG
(CHEMBL175205)
Show SMILES COc1ccc(O)c(CC(C)N)c1
Show InChI InChI=1S/C10H15NO2/c1-7(11)5-8-6-9(13-2)3-4-10(8)12/h3-4,6-7,12H,5,11H2,1-2H3
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n/an/an/a 148n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic against 5-hydroxytryptamine 2B receptor


J Med Chem 23: 990-4 (1980)


Article DOI: 10.1021/jm00183a006
BindingDB Entry DOI: 10.7270/Q2668FCW
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50005253
PNG
((+/-)1-Methyl-2-(2,4,5-trimethoxy-phenyl)-ethylami...)
Show SMILES COc1cc(OC)c(OC)cc1CC(C)N
Show InChI InChI=1S/C12H19NO3/c1-8(13)5-9-6-11(15-3)12(16-4)7-10(9)14-2/h6-8H,5,13H2,1-4H3
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n/an/an/a 155n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus


J Med Chem 24: 1414-21 (1982)


Article DOI: 10.1021/jm00144a009
BindingDB Entry DOI: 10.7270/Q2SX6FD3
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50409495
PNG
(CHEMBL111189)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN(CCC2CCc3sccc3C2=O)CC1
Show InChI InChI=1S/C24H29FN2O2S/c25-20-6-3-18(4-7-20)22(28)2-1-11-26-13-15-27(16-14-26)12-9-19-5-8-23-21(24(19)29)10-17-30-23/h3-4,6-7,10,17,19H,1-2,5,8-9,11-16H2
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n/an/an/a 158n/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus


J Med Chem 45: 54-71 (2001)


Article DOI: 10.1021/jm011014y
BindingDB Entry DOI: 10.7270/Q2KD204K
More data for this
Ligand-Target Pair
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