Compile Data Set for Download or QSAR
maximum 50k data
Found 22 of ki data for polymerid = 4928
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50139137(CHEMBL3759162)
Affinity DataKi:  2.39E+3nMAssay Description:Competitive inhibition of human serum PON1 using paraoxon as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM92331(Lornoxicam)
Affinity DataKi:  9.00E+3nM ΔG°:  -28.8kJ/mole IC50:  1.36E+5nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50001839(CHEMBL428647 | PACLITAXEL | taxol)
Affinity DataKi:  1.65E+4nM IC50:  4.20E+4nMpH: 10.5Assay Description:Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50316126(Bleph-10 | Bleph-30 | Blephamide | CHEMBL455 | Cet...)
Affinity DataKi:  8.60E+4nM IC50:  1.80E+5nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  9.70E+4nM ΔG°:  -22.9kJ/mole IC50:  1.95E+5nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataKi:  1.31E+5nM IC50:  2.26E+5nMpH: 10.5Assay Description:Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM241973(Oxytetracycline hydrochloride)
Affinity DataKi:  2.00E+5nMAssay Description:PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataKi:  2.91E+5nM IC50:  6.65E+5nMpH: 10.5Assay Description:Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM92332(Tenoxicam)
Affinity DataKi:  3.06E+5nM ΔG°:  -20.1kJ/mole IC50:  3.40E+5nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM10860(4-(aminomethyl)benzene-1-sulfonamide | CHEMBL419 |...)
Affinity DataKi:  3.40E+5nM IC50:  1.90E+5nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM82185(Sulfosalazine, 3)
Affinity DataKi:  5.70E+5nM IC50:  2.60E+5nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM25902(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
Affinity DataKi:  7.02E+5nM IC50:  3.60E+5nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  7.43E+5nM IC50:  8.00E+5nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)
Affinity DataKi:  8.05E+5nM ΔG°:  -17.7kJ/mole IC50:  1.64E+6nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM10868(1,3,4-Thiadiazole-2-sulfonamide, 6 | 1,3,4-thiadia...)
Affinity DataKi:  2.00E+6nM IC50:  1.24E+6nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM241974(Netilmycin sulfate)
Affinity DataKi:  3.73E+6nMAssay Description:PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM189358(Asta Z 4942 | Ifosfamide | Iphosphamide | N,3-bis(...)
Affinity DataKi:  8.97E+6nM IC50:  2.33E+7nMpH: 10.5Assay Description:Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM92333(Lincomycine)
Affinity DataKi:  1.11E+7nM ΔG°:  -11.2kJ/mole IC50:  1.30E+7nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50022271(2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...)
Affinity DataKi:  1.30E+7nM ΔG°:  -10.8kJ/mole IC50:  6.23E+6nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50335522((2S,4R)-N-((1R,2R)-2-hydroxy-1-((2R,3R,4S,5R,6R)-3...)
Affinity DataKi:  1.83E+7nMAssay Description:PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM241975(Clindamycin phosphate)
Affinity DataKi:  3.58E+7nMAssay Description:PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM241976(Streptomycin sulfate)
Affinity DataKi:  5.63E+7nMAssay Description:PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed