BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 14 hits of ki data for polymerid = 50004217,50007198   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
26S proteosome


(Homo sapiens (Human))
BDBM50010993
PNG
(CHEMBL3265177)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1nsc(=O)o1
Show InChI InChI=1S/C8H4N2O4S/c11-8-14-7(9-15-8)5-2-1-3-6(4-5)10(12)13/h1-4H
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
420n/an/an/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...


ACS Med Chem Lett 5: 405-10 (2014)


Article DOI: 10.1021/ml400531d
BindingDB Entry DOI: 10.7270/Q2PZ5BCF
More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50010988
PNG
(CHEMBL3259882)
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1ccc(cc1)-c1nsc(=O)o1
Show InChI InChI=1S/C19H17N3O4S/c1-12(23)20-16(11-13-5-3-2-4-6-13)17(24)21-15-9-7-14(8-10-15)18-22-27-19(25)26-18/h2-10,16H,11H2,1H3,(H,20,23)(H,21,24)/t16-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
520n/an/an/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...


ACS Med Chem Lett 5: 405-10 (2014)


Article DOI: 10.1021/ml400531d
BindingDB Entry DOI: 10.7270/Q2PZ5BCF
More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50010986
PNG
(CHEMBL2336253)
Show SMILES Cc1sc(cc1[N+]([O-])=O)-c1nsc(=O)o1
Show InChI InChI=1S/C7H4N2O4S2/c1-3-4(9(11)12)2-5(14-3)6-8-15-7(10)13-6/h2H,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
760n/an/an/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...


ACS Med Chem Lett 5: 405-10 (2014)


Article DOI: 10.1021/ml400531d
BindingDB Entry DOI: 10.7270/Q2PZ5BCF
More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50010995
PNG
(CHEMBL3265180)
Show SMILES O=c1oc(ns1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C10H6N2O2S/c13-10-14-9(12-15-10)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.10E+3n/an/an/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...


ACS Med Chem Lett 5: 405-10 (2014)


Article DOI: 10.1021/ml400531d
BindingDB Entry DOI: 10.7270/Q2PZ5BCF
More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50010997
PNG
(CHEMBL3265182)
Show SMILES CC(C)(C)OC(=O)Nc1ccc(cc1)-c1nsc(=O)o1
Show InChI InChI=1S/C13H14N2O4S/c1-13(2,3)19-11(16)14-9-6-4-8(5-7-9)10-15-20-12(17)18-10/h4-7H,1-3H3,(H,14,16)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.10E+3n/an/an/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...


ACS Med Chem Lett 5: 405-10 (2014)


Article DOI: 10.1021/ml400531d
BindingDB Entry DOI: 10.7270/Q2PZ5BCF
More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50011003
PNG
(CHEMBL3259879)
Show SMILES O=c1oc(ns1)-c1cccc(CN2CCOCC2)c1
Show InChI InChI=1S/C13H14N2O3S/c16-13-18-12(14-19-13)11-3-1-2-10(8-11)9-15-4-6-17-7-5-15/h1-3,8H,4-7,9H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.20E+3n/an/an/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...


ACS Med Chem Lett 5: 405-10 (2014)


Article DOI: 10.1021/ml400531d
BindingDB Entry DOI: 10.7270/Q2PZ5BCF
More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50010999
PNG
(CHEMBL3259876)
Show SMILES O=c1oc(ns1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C14H9NO2S/c16-14-17-13(15-18-14)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.40E+3n/an/an/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...


ACS Med Chem Lett 5: 405-10 (2014)


Article DOI: 10.1021/ml400531d
BindingDB Entry DOI: 10.7270/Q2PZ5BCF
More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50011001
PNG
(CHEMBL3259877)
Show SMILES Oc1cc(cc(O)c1O)-c1nsc(=O)o1
Show InChI InChI=1S/C8H5NO5S/c10-4-1-3(2-5(11)6(4)12)7-9-15-8(13)14-7/h1-2,10-12H
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.70E+3n/an/an/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...


ACS Med Chem Lett 5: 405-10 (2014)


Article DOI: 10.1021/ml400531d
BindingDB Entry DOI: 10.7270/Q2PZ5BCF
More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50010996
PNG
(CHEMBL3265181)
Show SMILES FC(F)(F)c1ccccc1-c1nsc(=O)o1
Show InChI InChI=1S/C9H4F3NO2S/c10-9(11,12)6-4-2-1-3-5(6)7-13-16-8(14)15-7/h1-4H
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
1.80E+3n/an/an/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...


ACS Med Chem Lett 5: 405-10 (2014)


Article DOI: 10.1021/ml400531d
BindingDB Entry DOI: 10.7270/Q2PZ5BCF
More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50010994
PNG
(CHEMBL3265178)
Show SMILES O=c1oc(ns1)-c1ccccn1
Show InChI InChI=1S/C7H4N2O2S/c10-7-11-6(9-12-7)5-3-1-2-4-8-5/h1-4H
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
2.00E+3n/an/an/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...


ACS Med Chem Lett 5: 405-10 (2014)


Article DOI: 10.1021/ml400531d
BindingDB Entry DOI: 10.7270/Q2PZ5BCF
More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50010987
PNG
(CHEMBL3259880)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)Nc1ccc(cc1)-c1nsc(=O)o1
Show InChI InChI=1S/C19H17N3O4S/c1-12(23)20-16(11-13-5-3-2-4-6-13)17(24)21-15-9-7-14(8-10-15)18-22-27-19(25)26-18/h2-10,16H,11H2,1H3,(H,20,23)(H,21,24)/t16-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.50E+3n/an/an/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...


ACS Med Chem Lett 5: 405-10 (2014)


Article DOI: 10.1021/ml400531d
BindingDB Entry DOI: 10.7270/Q2PZ5BCF
More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50010991
PNG
(CHEMBL3259884)
Show SMILES [N-]=[N+]=Nc1ccc(cc1)-c1nsc(=O)o1
Show InChI InChI=1S/C8H4N4O2S/c9-12-10-6-3-1-5(2-4-6)7-11-15-8(13)14-7/h1-4H
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
3.50E+3n/an/an/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...


ACS Med Chem Lett 5: 405-10 (2014)


Article DOI: 10.1021/ml400531d
BindingDB Entry DOI: 10.7270/Q2PZ5BCF
More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50011002
PNG
(CHEMBL3259878)
Show SMILES O=c1oc(ns1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C14H9NO2S/c16-14-17-13(15-18-14)12-8-4-7-11(9-12)10-5-2-1-3-6-10/h1-9H
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.00E+3n/an/an/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...


ACS Med Chem Lett 5: 405-10 (2014)


Article DOI: 10.1021/ml400531d
BindingDB Entry DOI: 10.7270/Q2PZ5BCF
More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50332796
PNG
(5-phenyl-1,3,4-oxathiazol-2-one | CHEMBL1632533)
Show SMILES O=c1oc(ns1)-c1ccccc1
Show InChI InChI=1S/C8H5NO2S/c10-8-11-7(9-12-8)6-4-2-1-3-5-6/h1-5H
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
7.90E+3n/an/an/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...


ACS Med Chem Lett 5: 405-10 (2014)


Article DOI: 10.1021/ml400531d
BindingDB Entry DOI: 10.7270/Q2PZ5BCF
More data for this
Ligand-Target Pair