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Compile Data Set for Download or QSAR

Found 29 hits of ki data for polymerid = 5715   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM2580
PNG
(K252a | methyl (15R,16S,18S)-16-hydroxy-15-methyl-...)
Show SMILES COC(=O)[C@]1(O)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18?,26-,27-/m1/s1
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17n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human myosin light chain kinase


Proc Natl Acad Sci U S A 104: 20523-8 (2007)

Checked by Author
Article DOI: 10.1073/pnas.0708800104
BindingDB Entry DOI: 10.7270/Q2DB82RH
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM6760
PNG
((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Show SMILES COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18?,26-,27-/m0/s1
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20n/an/an/an/an/an/an/an/a



Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL


Assay Description
Inhibition of MLCK by HTRF assay


Bioorg Med Chem 19: 429-39 (2011)


Article DOI: 10.1016/j.bmc.2010.11.007
BindingDB Entry DOI: 10.7270/Q22F7NQN
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307668
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1cnc(cn1)C1CC1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C25H21N7O/c33-25-19-10-16(22-12-26-21(11-27-22)15-4-5-15)6-7-17(19)13-31(25)23-3-1-2-20(29-23)24-30-28-14-32(24)18-8-9-18/h1-3,6-7,10-12,14-15,18H,4-5,8-9,13H2
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<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307672
PNG
(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Show SMILES Cc1cc2CN(C(=O)c2cc1-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H20N6O/c1-15-10-17-13-29(24(31)20(17)11-19(15)16-4-3-9-25-12-16)22-6-2-5-21(27-22)23-28-26-14-30(23)18-7-8-18/h2-6,9-12,14,18H,7-8,13H2,1H3
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<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307674
PNG
(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Show SMILES COc1cc2CN(C(=O)c2cc1-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H20N6O2/c1-32-21-10-16-13-29(24(31)19(16)11-18(21)15-4-3-9-25-12-15)22-6-2-5-20(27-22)23-28-26-14-30(23)17-7-8-17/h2-6,9-12,14,17H,7-8,13H2,1H3
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<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307654
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1ccc(nc1)C1CC1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C26H22N6O/c33-26-21-12-17(18-8-11-22(27-13-18)16-4-5-16)6-7-19(21)14-31(26)24-3-1-2-23(29-24)25-30-28-15-32(25)20-9-10-20/h1-3,6-8,11-13,15-16,20H,4-5,9-10,14H2
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<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307649
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Cc1ccncc1-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H20N6O/c1-15-9-10-25-12-20(15)16-5-6-17-13-29(24(31)19(17)11-16)22-4-2-3-21(27-22)23-28-26-14-30(23)18-7-8-18/h2-6,9-12,14,18H,7-8,13H2,1H3
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<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307648
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H18N6O/c30-23-19-11-15(16-3-2-10-24-12-16)6-7-17(19)13-28(23)21-5-1-4-20(26-21)22-27-25-14-29(22)18-8-9-18/h1-7,10-12,14,18H,8-9,13H2
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<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307686
PNG
(2-(6-(5-methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4...)
Show SMILES CC1CCc2nnc(-c3cccc(n3)N3Cc4ccccc4C3=O)n12
Show InChI InChI=1S/C19H17N5O/c1-12-9-10-17-21-22-18(24(12)17)15-7-4-8-16(20-15)23-11-13-5-2-3-6-14(13)19(23)25/h2-8,12H,9-11H2,1H3
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<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307609
PNG
(2-(6-(4-Cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Show SMILES O=C1N(Cc2ccccc12)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C18H15N5O/c24-18-14-5-2-1-4-12(14)10-22(18)16-7-3-6-15(20-16)17-21-19-11-23(17)13-8-9-13/h1-7,11,13H,8-10H2
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<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM50216683
PNG
(1-(5-iodonaphthalen-1-ylsulfonyl)-1,4-diazepane | ...)
Show SMILES Ic1cccc2c(cccc12)S(=O)(=O)N1CCCNCC1
Show InChI InChI=1S/C15H17IN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2
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300n/an/an/an/an/an/an/an/a



Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL


Assay Description
Inhibition of MLCK by HTRF assay


Bioorg Med Chem 19: 429-39 (2011)


Article DOI: 10.1016/j.bmc.2010.11.007
BindingDB Entry DOI: 10.7270/Q22F7NQN
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307636
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2cc(ccc12)-c1cc[nH]n1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C21H17N7O/c29-21-16-7-4-13(17-8-9-22-25-17)10-14(16)11-27(21)19-3-1-2-18(24-19)20-26-23-12-28(20)15-5-6-15/h1-4,7-10,12,15H,5-6,11H2,(H,22,25)
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600n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307679
PNG
(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Show SMILES O=C(N1CCCC1)c1cc2CN(C(=O)c2cc1-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C28H25N7O2/c36-27(33-11-1-2-12-33)23-13-19-16-34(28(37)22(19)14-21(23)18-5-4-10-29-15-18)25-7-3-6-24(31-25)26-32-30-17-35(26)20-8-9-20/h3-7,10,13-15,17,20H,1-2,8-9,11-12,16H2
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600n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307677
PNG
(US10150755, Compound 69)
Show SMILES O=C1N(Cc2cc(OC3CCCC3)c(cc12)-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C28H26N6O2/c35-28-23-14-22(18-5-4-12-29-15-18)25(36-21-6-1-2-7-21)13-19(23)16-33(28)26-9-3-8-24(31-26)27-32-30-17-34(27)20-10-11-20/h3-5,8-9,12-15,17,20-21H,1-2,6-7,10-11,16H2
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600n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307676
PNG
(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Show SMILES CC(C)Oc1cc2CN(C(=O)c2cc1-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C26H24N6O2/c1-16(2)34-23-11-18-14-31(26(33)21(18)12-20(23)17-5-4-10-27-13-17)24-7-3-6-22(29-24)25-30-28-15-32(25)19-8-9-19/h3-7,10-13,15-16,19H,8-9,14H2,1-2H3
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600n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307640
PNG
(N-(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyrid...)
Show SMILES CC(=O)Nc1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C20H18N6O2/c1-12(27)22-14-5-8-16-13(9-14)10-25(20(16)28)18-4-2-3-17(23-18)19-24-21-11-26(19)15-6-7-15/h2-5,8-9,11,15H,6-7,10H2,1H3,(H,22,27)
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600n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307638
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Cn1cnc(c1)-c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H19N7O/c1-27-11-19(23-12-27)14-5-8-17-15(9-14)10-28(22(17)30)20-4-2-3-18(25-20)21-26-24-13-29(21)16-6-7-16/h2-5,8-9,11-13,16H,6-7,10H2,1H3
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600n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM15236
PNG
(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
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1.70E+3n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of MLCK


J Nat Prod 69: 14-7 (2006)


Article DOI: 10.1021/np050229y
BindingDB Entry DOI: 10.7270/Q2FJ2GHF
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM50216681
PNG
(1-(5-chloronaphthalen-1-ylsulfonyl)-1,4-diazepane ...)
Show SMILES Clc1cccc2c(cccc12)S(=O)(=O)N1CCCNCC1
Show InChI InChI=1S/C15H17ClN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2
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3.80E+3n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of myosin light chain kinase


Proc Natl Acad Sci U S A 104: 20523-8 (2007)

Checked by Author
Article DOI: 10.1073/pnas.0708800104
BindingDB Entry DOI: 10.7270/Q2DB82RH
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM50216681
PNG
(1-(5-chloronaphthalen-1-ylsulfonyl)-1,4-diazepane ...)
Show SMILES Clc1cccc2c(cccc12)S(=O)(=O)N1CCCNCC1
Show InChI InChI=1S/C15H17ClN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2
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3.80E+3n/an/an/an/an/an/an/an/a



Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL


Assay Description
Inhibition of MLCK by HTRF assay


Bioorg Med Chem 19: 429-39 (2011)


Article DOI: 10.1016/j.bmc.2010.11.007
BindingDB Entry DOI: 10.7270/Q22F7NQN
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307615
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C(N1CCOCC1)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H22N6O3/c30-22(27-8-10-32-11-9-27)15-4-7-18-16(12-15)13-28(23(18)31)20-3-1-2-19(25-20)21-26-24-14-29(21)17-5-6-17/h1-4,7,12,14,17H,5-6,8-11,13H2
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5.50E+3n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307682
PNG
(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Show SMILES CN(C)C(=O)c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C21H20N6O2/c1-25(2)20(28)13-6-7-14-11-26(21(29)16(14)10-13)18-5-3-4-17(23-18)19-24-22-12-27(19)15-8-9-15/h3-7,10,12,15H,8-9,11H2,1-2H3
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5.50E+3n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307671
PNG
(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Show SMILES Fc1cc2CN(C(=O)c2cc1-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H17FN6O/c24-19-9-15-12-29(23(31)18(15)10-17(19)14-3-2-8-25-11-14)21-5-1-4-20(27-21)22-28-26-13-30(22)16-6-7-16/h1-5,8-11,13,16H,6-7,12H2
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5.50E+3n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM307673
PNG
(5-chloro-2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl...)
Show SMILES Clc1cc2CN(C(=O)c2cc1-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H17ClN6O/c24-19-9-15-12-29(23(31)18(15)10-17(19)14-3-2-8-25-11-14)21-5-1-4-20(27-21)22-28-26-13-30(22)16-6-7-16/h1-5,8-11,13,16H,6-7,12H2
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5.50E+3n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)


Article DOI: 10.1080/14756360310001640913
BindingDB Entry DOI: 10.7270/Q2125VQ8
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM50375645
PNG
(CHEMBL219301)
Show SMILES NCCNS(=O)(=O)c1cccc2c(Cl)cccc12
Show InChI InChI=1S/C12H13ClN2O2S/c13-11-5-1-4-10-9(11)3-2-6-12(10)18(16,17)15-8-7-14/h1-6,15H,7-8,14H2
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7.40E+3n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of myosin light chain kinase


Proc Natl Acad Sci U S A 104: 20523-8 (2007)

Checked by Author
Article DOI: 10.1073/pnas.0708800104
BindingDB Entry DOI: 10.7270/Q2DB82RH
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM14028
PNG
((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Show SMILES C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(C)c12
Show InChI InChI=1S/C16H21N3O2S/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)19-8-4-7-17-10-13(19)2/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3/t13-/m0/s1
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1.01E+4n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Binding affinity at MLCK


Proc Natl Acad Sci U S A 104: 20523-8 (2007)

Checked by Author
Article DOI: 10.1073/pnas.0708800104
BindingDB Entry DOI: 10.7270/Q2DB82RH
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM15211
PNG
(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Show SMILES Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1
Show InChI InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+
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2.83E+4n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Binding affinity at MLCK


Proc Natl Acad Sci U S A 104: 20523-8 (2007)

Checked by Author
Article DOI: 10.1073/pnas.0708800104
BindingDB Entry DOI: 10.7270/Q2DB82RH
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM50111446
PNG
(5-Chloro-naphthalene-1-sulfonic acid (6-amino-hexy...)
Show SMILES NCCCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12
Show InChI InChI=1S/C16H21ClN2O2S/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18/h5-10,19H,1-4,11-12,18H2
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1.10E+5n/an/an/an/an/an/an/an/a



Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL


Assay Description
Inhibition of MLCK by HTRF assay


Bioorg Med Chem 19: 429-39 (2011)


Article DOI: 10.1016/j.bmc.2010.11.007
BindingDB Entry DOI: 10.7270/Q22F7NQN
More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens (Human))
BDBM50216680
PNG
(1-(2-(isoquinoline-5-sulfonamido)ethyl)guanidine |...)
Show SMILES NC(N)=NCCNS(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C12H15N5O2S/c13-12(14)16-6-7-17-20(18,19)11-3-1-2-9-8-15-5-4-10(9)11/h1-5,8,17H,6-7H2,(H4,13,14,16)
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1.50E+5n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Binding affinity at MLCK


Proc Natl Acad Sci U S A 104: 20523-8 (2007)

Checked by Author
Article DOI: 10.1073/pnas.0708800104
BindingDB Entry DOI: 10.7270/Q2DB82RH
More data for this
Ligand-Target Pair