BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1136 hits Enz. Inhib. hit(s) with Target = 'AMP-activated protein kinase, alpha-2 subunit'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244234
PNG
(US9428501, 58)
Show SMILES CCOc1cnc(CN2CCC(CC2)n2cc3cc(ccc3n2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C32H36F3N7O2/c1-2-44-30-19-36-27(18-37-30)22-39-11-9-28(10-12-39)42-21-25-17-24(5-8-29(25)38-42)31(43)41-15-13-40(14-16-41)20-23-3-6-26(7-4-23)32(33,34)35/h3-8,17-19,21,28H,2,9-16,20,22H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.860n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244236
PNG
(US9428501, 69)
Show SMILES CCOc1cnc(CN2CCC(CC2)c2ccc3cc(C(=O)N4CCN(Cc5ccc(cc5)C#N)CC4)n(C)c3c2)cn1
Show InChI InChI=1S/C34H39N7O2/c1-3-43-33-22-36-30(21-37-33)24-39-12-10-27(11-13-39)28-8-9-29-19-32(38(2)31(29)18-28)34(42)41-16-14-40(15-17-41)23-26-6-4-25(20-35)5-7-26/h4-9,18-19,21-22,27H,3,10-17,23-24H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.80n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244233
PNG
(US9428501, 57)
Show SMILES COc1ccc(CN2CCC(CC2)n2cc3cc(ccc3n2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C32H35F3N6O2/c1-43-30-9-4-24(19-36-30)21-38-12-10-28(11-13-38)41-22-26-18-25(5-8-29(26)37-41)31(42)40-16-14-39(15-17-40)20-23-2-6-27(7-3-23)32(33,34)35/h2-9,18-19,22,28H,10-17,20-21H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.80n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244235
PNG
(US9428501, 66)
Show SMILES CCOc1cnc(CN2CCC(CC2)c2ccc3n(C)c(cc3c2)C(=O)N2CCN(Cc3ccc(cc3)C#N)CC2)cn1
Show InChI InChI=1S/C34H39N7O2/c1-3-43-33-22-36-30(21-37-33)24-39-12-10-27(11-13-39)28-8-9-31-29(18-28)19-32(38(31)2)34(42)41-16-14-40(15-17-41)23-26-6-4-25(20-35)5-7-26/h4-9,18-19,21-22,27H,3,10-17,23-24H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.80n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244223
PNG
(US9428501, 18)
Show SMILES COc1ccc(CN2CCC(CC2)c2ccc3nc(C(=O)N4CCN(Cc5ccc(cc5)C(F)(F)F)CC4)n(C)c3c2)cn1
Show InChI InChI=1S/C33H37F3N6O2/c1-39-29-19-26(25-11-13-40(14-12-25)22-24-5-10-30(44-2)37-20-24)6-9-28(29)38-31(39)32(43)42-17-15-41(16-18-42)21-23-3-7-27(8-4-23)33(34,35)36/h3-10,19-20,25H,11-18,21-22H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244237
PNG
(US9428501, 79)
Show SMILES COc1cnc(CN2CCC(CC2)c2ccc3n(C)c(cc3c2)C(=O)N2CCN(Cc3ccc(cc3)C#N)CC2)cn1
Show InChI InChI=1S/C33H37N7O2/c1-37-30-8-7-27(26-9-11-38(12-10-26)23-29-20-36-32(42-2)21-35-29)17-28(30)18-31(37)33(41)40-15-13-39(14-16-40)22-25-5-3-24(19-34)4-6-25/h3-8,17-18,20-21,26H,9-16,22-23H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.30n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244226
PNG
(US9428501, 35)
Show SMILES COc1ccc(CN2CCC(CC2)c2ccc3nc(cn3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C32H35F3N6O2/c1-43-30-9-4-24(18-36-30)20-38-12-10-25(11-13-38)26-5-8-29-37-28(22-41(29)21-26)31(42)40-16-14-39(15-17-40)19-23-2-6-27(7-3-23)32(33,34)35/h2-9,18,21-22,25H,10-17,19-20H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.60n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244227
PNG
(US9428501, 36)
Show SMILES COc1ccc(CN2CCC(CC2)c2ccn3cc(nc3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C32H35F3N6O2/c1-43-30-7-4-24(19-36-30)21-38-11-8-25(9-12-38)26-10-13-41-22-28(37-29(41)18-26)31(42)40-16-14-39(15-17-40)20-23-2-5-27(6-3-23)32(33,34)35/h2-7,10,13,18-19,22,25H,8-9,11-12,14-17,20-21H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.10n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244230
PNG
(US9428501, 44)
Show SMILES COc1ccc(CN2CCC(CC2)c2cc3cc(C(=O)N4CCN(Cc5ccc(cc5)C(F)(F)F)CC4)n(C)c3cn2)cn1
Show InChI InChI=1S/C33H37F3N6O2/c1-39-29(32(43)42-15-13-41(14-16-42)21-23-3-6-27(7-4-23)33(34,35)36)18-26-17-28(37-20-30(26)39)25-9-11-40(12-10-25)22-24-5-8-31(44-2)38-19-24/h3-8,17-20,25H,9-16,21-22H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.20n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244231
PNG
(US9428501, 49)
Show SMILES COc1ccc(CN2CCC(CC2)c2ccn3nc(cc3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C32H35F3N6O2/c1-43-30-7-4-24(20-36-30)22-38-11-8-25(9-12-38)26-10-13-41-28(18-26)19-29(37-41)31(42)40-16-14-39(15-17-40)21-23-2-5-27(6-3-23)32(33,34)35/h2-7,10,13,18-20,25H,8-9,11-12,14-17,21-22H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 6.5n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244220
PNG
(US9428501, 7)
Show SMILES COc1cnc(CN2CCC(CC2)c2ccc3[nH]c(nc3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C31H34F3N7O2/c1-43-28-18-35-25(17-36-28)20-39-10-8-22(9-11-39)23-4-7-26-27(16-23)38-29(37-26)30(42)41-14-12-40(13-15-41)19-21-2-5-24(6-3-21)31(32,33)34/h2-7,16-18,22H,8-15,19-20H2,1H3,(H,37,38)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.30n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244228
PNG
(US9428501, 37)
Show SMILES COc1ccc(CN2CCC(CC2)c2ccc3nc([nH]c3c2)C(=O)N2CCN(Cc3ccc4OC(F)(F)Oc4c3)CC2)cn1
Show InChI InChI=1S/C32H34F2N6O4/c1-42-29-7-3-22(18-35-29)20-38-10-8-23(9-11-38)24-4-5-25-26(17-24)37-30(36-25)31(41)40-14-12-39(13-15-40)19-21-2-6-27-28(16-21)44-32(33,34)43-27/h2-7,16-18,23H,8-15,19-20H2,1H3,(H,36,37)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 10n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244224
PNG
(US9428501, 19)
Show SMILES COc1ccc(CN2CCC(CC2)c2ccc3n(C)c(nc3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C33H37F3N6O2/c1-39-29-9-6-26(25-11-13-40(14-12-25)22-24-5-10-30(44-2)37-20-24)19-28(29)38-31(39)32(43)42-17-15-41(16-18-42)21-23-3-7-27(8-4-23)33(34,35)36/h3-10,19-20,25H,11-18,21-22H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 10n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244229
PNG
(US9428501, 38)
Show SMILES COc1ccc(CN2CCC(CC2)c2ccc3nc([nH]c3c2)C(=O)N2CCN(Cc3ccc(cc3F)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C32H34F4N6O2/c1-44-29-7-2-21(18-37-29)19-40-10-8-22(9-11-40)23-4-6-27-28(16-23)39-30(38-27)31(43)42-14-12-41(13-15-42)20-24-3-5-25(17-26(24)33)32(34,35)36/h2-7,16-18,22H,8-15,19-20H2,1H3,(H,38,39)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 13n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244221
PNG
(US9428501, 8)
Show SMILES COc1cnc(CN2CCC(CC2)c2ccc3nc([nH]c3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C31H34F3N7O2/c1-43-28-18-35-25(17-36-28)20-39-10-8-22(9-11-39)23-4-7-26-27(16-23)38-29(37-26)30(42)41-14-12-40(13-15-41)19-21-2-5-24(6-3-21)31(32,33)34/h2-7,16-18,22H,8-15,19-20H2,1H3,(H,37,38)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 13n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244232
PNG
(US9428501, 50)
Show SMILES COc1cnc(CN2CCC(CC2)c2ccn3nc(cc3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C31H34F3N7O2/c1-43-29-19-35-26(18-36-29)21-38-9-6-23(7-10-38)24-8-11-41-27(16-24)17-28(37-41)30(42)40-14-12-39(13-15-40)20-22-2-4-25(5-3-22)31(32,33)34/h2-5,8,11,16-19,23H,6-7,9-10,12-15,20-21H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 14n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244225
PNG
(US9428501, 23)
Show SMILES COc1ccc(CN2CCC(CC2)c2ccc3nc([nH]c3c2)C(=O)N2CCN(Cc3ccc(cc3)C#N)CC2)cn1
Show InChI InChI=1S/C32H35N7O2/c1-41-30-9-6-25(20-34-30)22-37-12-10-26(11-13-37)27-7-8-28-29(18-27)36-31(35-28)32(40)39-16-14-38(15-17-39)21-24-4-2-23(19-33)3-5-24/h2-9,18,20,26H,10-17,21-22H2,1H3,(H,35,36)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 19n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244219
PNG
(US9428501, 1)
Show SMILES COc1ccc(CN2CCC(CC2)c2ccc3[nH]c(nc3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C32H35F3N6O2/c1-43-29-9-4-23(19-36-29)21-39-12-10-24(11-13-39)25-5-8-27-28(18-25)38-30(37-27)31(42)41-16-14-40(15-17-41)20-22-2-6-26(7-3-22)32(33,34)35/h2-9,18-19,24H,10-17,20-21H2,1H3,(H,37,38)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 24n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
AMPK subunit alpha-2


(Homo sapiens (Human))
BDBM244222
PNG
(US9428501, 14)
Show SMILES COc1ccc(CN2CCC(CC2)c2ccc3nc([nH]c3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cc1
Show InChI InChI=1S/C33H36F3N5O2/c1-43-28-9-4-24(5-10-28)21-39-14-12-25(13-15-39)26-6-11-29-30(20-26)38-31(37-29)32(42)41-18-16-40(17-19-41)22-23-2-7-27(8-3-23)33(34,35)36/h2-11,20,25H,12-19,21-22H2,1H3,(H,37,38)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 34n/an/an/a37



Astellas Pharma Inc

US Patent


Assay Description
In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...


US Patent US9428501 (2016)


BindingDB Entry DOI: 10.7270/Q28051JK
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM409400
PNG
(N-((3S,4R)-3-fluoro-1-((5-methylisoxazol- 3-yl)met...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@@H]1CCN(Cc2cc(C)on2)C[C@@H]1F
Show InChI InChI=1S/C30H34FN5O5/c1-19-15-23(34-41-19)17-35-12-11-26(25(31)18-35)33-29(38)22-5-8-27(32-16-22)30(39)36-13-9-21(10-14-36)28(37)20-3-6-24(40-2)7-4-20/h3-8,15-16,21,25-26H,9-14,17-18H2,1-2H3,(H,33,38)/t25-,26+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328292
PNG
(6-(4-(4-methoxybenzoyl) piperidine-1-carbonyl)- N...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1
Show InChI InChI=1S/C33H35F3N4O5/c1-44-27-9-4-23(5-10-27)30(41)24-12-18-40(19-13-24)32(43)29-11-6-25(20-37-29)31(42)38-26-14-16-39(17-15-26)21-22-2-7-28(8-3-22)45-33(34,35)36/h2-11,20,24,26H,12-19,21H2,1H3,(H,38,42)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328295
PNG
(6-(4-(3-(cyclopropane- carboxamido)phenoxy) piper...)
Show SMILES Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3cccc(NC(=O)C4CC4)c3)cn2)cc1
Show InChI InChI=1S/C33H30FN5O5/c34-23-7-10-26(11-8-23)44-30-13-9-25(20-36-30)38-32(41)22-6-12-29(35-19-22)33(42)39-16-14-27(15-17-39)43-28-3-1-2-24(18-28)37-31(40)21-4-5-21/h1-3,6-13,18-21,27H,4-5,14-17H2,(H,37,40)(H,38,41)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM409408
PNG
(N-((cis)-4-(4-cyanophenoxy)cyclohexyl)-6- (4-(3- (...)
Show SMILES O=C(Nc1cccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(cc2)C#N)c1)C1CC1
Show InChI InChI=1S/C35H37N5O5/c36-21-23-4-11-28(12-5-23)44-29-13-9-26(10-14-29)38-34(42)25-8-15-32(37-22-25)35(43)40-18-16-30(17-19-40)45-31-3-1-2-27(20-31)39-33(41)24-6-7-24/h1-5,8,11-12,15,20,22,24,26,29-30H,6-7,9-10,13-14,16-19H2,(H,38,42)(H,39,41)/t26-,29+
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328297
PNG
(6-(4-(3-(cyclopropane- carboxamido)phenoxy) piper...)
Show SMILES COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2cccc(NC(=O)C3CC3)c2)cc1
Show InChI InChI=1S/C35H41N5O5/c1-44-29-10-5-24(6-11-29)23-39-17-13-27(14-18-39)37-34(42)26-9-12-32(36-22-26)35(43)40-19-15-30(16-20-40)45-31-4-2-3-28(21-31)38-33(41)25-7-8-25/h2-6,9-12,21-22,25,27,30H,7-8,13-20,23H2,1H3,(H,37,42)(H,38,41)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328298
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (tr...)
Show SMILES FC(F)(F)Sc1ccc(OC2CCN(CC2)C(=O)c2ccc(nn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1
Show InChI InChI=1S/C31H31F3N6O3S/c32-31(33,34)44-26-7-5-24(6-8-26)43-25-13-17-40(18-14-25)30(42)28-10-9-27(37-38-28)29(41)36-23-11-15-39(16-12-23)20-22-3-1-21(19-35)2-4-22/h1-10,23,25H,11-18,20H2,(H,36,41)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328299
PNG
(6-(4-(4-acetylphenoxy) piperidine-1-carbonyl)- N-...)
Show SMILES CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1
Show InChI InChI=1S/C32H34N6O4/c1-22(39)25-6-8-27(9-7-25)42-28-14-18-38(19-15-28)32(41)30-11-10-29(35-36-30)31(40)34-26-12-16-37(17-13-26)21-24-4-2-23(20-33)3-5-24/h2-11,26,28H,12-19,21H2,1H3,(H,34,40)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328300
PNG
(6-(4-(3-(cyclopropane- carboxamido)phenoxy) piper...)
Show SMILES FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2cccc(NC(=O)C3CC3)c2)cc1
Show InChI InChI=1S/C35H38F3N5O5/c36-35(37,38)48-29-9-4-23(5-10-29)22-42-16-12-26(13-17-42)40-33(45)25-8-11-31(39-21-25)34(46)43-18-14-28(15-19-43)47-30-3-1-2-27(20-30)41-32(44)24-6-7-24/h1-5,8-11,20-21,24,26,28H,6-7,12-19,22H2,(H,40,45)(H,41,44)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328301
PNG
(N-(1-(4-methoxybenzyl) piperidin-4-yl)-6-(4-(4- (...)
Show SMILES COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)cc1
Show InChI InChI=1S/C36H43N5O4/c1-45-32-11-4-26(5-12-32)25-39-20-16-30(17-21-39)38-35(43)29-8-13-33(37-24-29)36(44)41-22-14-28(15-23-41)34(42)27-6-9-31(10-7-27)40-18-2-3-19-40/h4-13,24,28,30H,2-3,14-23,25H2,1H3,(H,38,43)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328302
PNG
(6-(4-(4-(pyrrolidin-1- yl)benzoyl)piperidine-1- ca...)
Show SMILES FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)cc1
Show InChI InChI=1S/C36H40F3N5O4/c37-36(38,39)48-31-10-3-25(4-11-31)24-42-19-15-29(16-20-42)41-34(46)28-7-12-32(40-23-28)35(47)44-21-13-27(14-22-44)33(45)26-5-8-30(9-6-26)43-17-1-2-18-43/h3-12,23,27,29H,1-2,13-22,24H2,(H,41,46)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328303
PNG
(6-(4-(4-(pyrrolidin-1- yl)benzoyl)piperidine-1- ca...)
Show SMILES FC(F)(F)Oc1cccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)c1
Show InChI InChI=1S/C36H40F3N5O4/c37-36(38,39)48-31-5-3-4-25(22-31)24-42-18-14-29(15-19-42)41-34(46)28-8-11-32(40-23-28)35(47)44-20-12-27(13-21-44)33(45)26-6-9-30(10-7-26)43-16-1-2-17-43/h3-11,22-23,27,29H,1-2,12-21,24H2,(H,41,46)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM409416
PNG
(N-((cis)-4-(4-cyanophenoxy)cyclohexyl)-6- (4-(4-(p...)
Show SMILES O=C(N[C@H]1CC[C@H](CC1)Oc1ccc(cc1)C#N)c1ccc(nc1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)N1CCCC1
Show InChI InChI=1S/C36H39N5O4/c37-23-25-3-12-31(13-4-25)45-32-14-8-29(9-15-32)39-35(43)28-7-16-33(38-24-28)36(44)41-21-17-27(18-22-41)34(42)26-5-10-30(11-6-26)40-19-1-2-20-40/h3-7,10-13,16,24,27,29,32H,1-2,8-9,14-15,17-22H2,(H,39,43)/t29-,32+
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328305
PNG
(N-(1-(3-fluoro-4- methoxybenzyl) piperidin-4-yl)-...)
Show SMILES COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)cc1F
Show InChI InChI=1S/C36H42FN5O4/c1-46-33-11-4-25(22-31(33)37)24-40-18-14-29(15-19-40)39-35(44)28-7-10-32(38-23-28)36(45)42-20-12-27(13-21-42)34(43)26-5-8-30(9-6-26)41-16-2-3-17-41/h4-11,22-23,27,29H,2-3,12-21,24H2,1H3,(H,39,44)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328306
PNG
(6-(4-(4-(pyrrolidin-1- yl)benzoyl)piperidine-1- ca...)
Show SMILES O=C(NC1CCN(Cc2ccc(cc2)N2CCCC2)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)N1CCCC1
Show InChI InChI=1S/C39H48N6O3/c46-37(30-7-12-35(13-8-30)44-21-3-4-22-44)31-15-25-45(26-16-31)39(48)36-14-9-32(27-40-36)38(47)41-33-17-23-42(24-18-33)28-29-5-10-34(11-6-29)43-19-1-2-20-43/h5-14,27,31,33H,1-4,15-26,28H2,(H,41,47)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328308
PNG
(N-(1-(4- isopropoxybenzyl) piperidin-4-yl)-6-(4-(...)
Show SMILES CC(C)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)cc1
Show InChI InChI=1S/C38H47N5O4/c1-27(2)47-34-12-5-28(6-13-34)26-41-21-17-32(18-22-41)40-37(45)31-9-14-35(39-25-31)38(46)43-23-15-30(16-24-43)36(44)29-7-10-33(11-8-29)42-19-3-4-20-42/h5-14,25,27,30,32H,3-4,15-24,26H2,1-2H3,(H,40,45)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328309
PNG
(N-(1-(4-cyano-3- fluorobenzyl)piperidin- 4-yl)-6-(...)
Show SMILES Fc1cc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)ccc1C#N
Show InChI InChI=1S/C36H39FN6O3/c37-32-21-25(3-4-28(32)22-38)24-41-17-13-30(14-18-41)40-35(45)29-7-10-33(39-23-29)36(46)43-19-11-27(12-20-43)34(44)26-5-8-31(9-6-26)42-15-1-2-16-42/h3-10,21,23,27,30H,1-2,11-20,24H2,(H,40,45)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328312
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (tr...)
Show SMILES FC(F)(F)S(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1
Show InChI InChI=1S/C32H32F3N5O5S/c33-32(34,35)46(43,44)28-8-6-26(7-9-28)45-27-13-17-40(18-14-27)31(42)29-10-5-24(20-37-29)30(41)38-25-11-15-39(16-12-25)21-23-3-1-22(19-36)2-4-23/h1-10,20,25,27H,11-18,21H2,(H,38,41)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM409425
PNG
(N-((trans)-1-(4-cyanobenzyl)-3- fluoropiperidin-4-...)
Show SMILES F[C@@H]1CN(Cc2ccc(cc2)C#N)CC[C@H]1NC(=O)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C32H31F4N5O5S/c33-27-20-40(19-22-3-1-21(17-37)2-4-22)14-13-28(27)39-30(42)23-5-10-29(38-18-23)31(43)41-15-11-25(12-16-41)46-24-6-8-26(9-7-24)47(44,45)32(34,35)36/h1-10,18,25,27-28H,11-16,19-20H2,(H,39,42)/t27-,28-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328314
PNG
(N-((3R,4R)-1-(4- cyanobenzyl)-3- fluoropiperidin-4...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@@H]1CCN(Cc2ccc(cc2)C#N)C[C@H]1F
Show InChI InChI=1/C33H34FN5O4/c1-43-27-9-6-24(7-10-27)31(40)25-12-16-39(17-13-25)33(42)30-11-8-26(19-36-30)32(41)37-29-14-15-38(21-28(29)34)20-23-4-2-22(18-35)3-5-23/h2-11,19,25,28-29H,12-17,20-21H2,1H3,(H,37,41)/t28-,29-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328315
PNG
(N-((3S,4S)-1-(4- cyanobenzyl)-3- fluoropiperidin-4...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@H]1CCN(Cc2ccc(cc2)C#N)C[C@@H]1F
Show InChI InChI=1/C33H34FN5O4/c1-43-27-9-6-24(7-10-27)31(40)25-12-16-39(17-13-25)33(42)30-11-8-26(19-36-30)32(41)37-29-14-15-38(21-28(29)34)20-23-4-2-22(18-35)3-5-23/h2-11,19,25,28-29H,12-17,20-21H2,1H3,(H,37,41)/t28-,29-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM409428
PNG
(N-((cis)-1-(4-cyanobenzyl)-3- fluoropiperidin-4-yl...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@@H]1CCN(Cc2ccc(cc2)C#N)C[C@@H]1F
Show InChI InChI=1S/C33H34FN5O4/c1-43-27-9-6-24(7-10-27)31(40)25-12-16-39(17-13-25)33(42)30-11-8-26(19-36-30)32(41)37-29-14-15-38(21-28(29)34)20-23-4-2-22(18-35)3-5-23/h2-11,19,25,28-29H,12-17,20-21H2,1H3,(H,37,41)/t28-,29+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328317
PNG
(6-(4-(4- (cyclopropanecarbonyl) phenoxy)piperidin...)
Show SMILES FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C(=O)C2CC2)cc1
Show InChI InChI=1S/C35H37F3N4O5/c36-35(37,38)47-30-8-1-23(2-9-30)22-41-17-13-27(14-18-41)40-33(44)26-7-12-31(39-21-26)34(45)42-19-15-29(16-20-42)46-28-10-5-25(6-11-28)32(43)24-3-4-24/h1-2,5-12,21,24,27,29H,3-4,13-20,22H2,(H,40,44)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328318
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4- (cyclo...)
Show SMILES O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C(=O)C1CC1
Show InChI InChI=1S/C35H37N5O4/c36-21-24-1-3-25(4-2-24)23-39-17-13-29(14-18-39)38-34(42)28-9-12-32(37-22-28)35(43)40-19-15-31(16-20-40)44-30-10-7-27(8-11-30)33(41)26-5-6-26/h1-4,7-12,22,26,29,31H,5-6,13-20,23H2,(H,38,42)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328319
PNG
(6-(4-(4- (cyclopropanecarbonyl) phenoxy)piperidin...)
Show SMILES Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(cc3)C(=O)C3CC3)cn2)cc1
Show InChI InChI=1S/C33H29FN4O5/c34-24-6-11-27(12-7-24)43-30-14-8-25(20-36-30)37-32(40)23-5-13-29(35-19-23)33(41)38-17-15-28(16-18-38)42-26-9-3-22(4-10-26)31(39)21-1-2-21/h3-14,19-21,28H,1-2,15-18H2,(H,37,40)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328320
PNG
(6-(4-(4- (cyclopropanecarbonyl) phenoxy)piperidin...)
Show SMILES COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C(=O)C2CC2)cc1
Show InChI InChI=1S/C35H40N4O5/c1-43-29-9-2-24(3-10-29)23-38-18-14-28(15-19-38)37-34(41)27-8-13-32(36-22-27)35(42)39-20-16-31(17-21-39)44-30-11-6-26(7-12-30)33(40)25-4-5-25/h2-3,6-13,22,25,28,31H,4-5,14-21,23H2,1H3,(H,37,41)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328321
PNG
(N-(6-(4- cyanophenoxy)pyridin- 3-yl)-6-(4-(4- (met...)
Show SMILES CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)nc2)cc1
Show InChI InChI=1S/C31H27N5O6S/c1-43(39,40)27-10-8-24(9-11-27)41-26-14-16-36(17-15-26)31(38)28-12-4-22(19-33-28)30(37)35-23-5-13-29(34-20-23)42-25-6-2-21(18-32)3-7-25/h2-13,19-20,26H,14-17H2,1H3,(H,35,37)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328322
PNG
(N-(6-(4- cyanophenoxy)pyridin- 3-yl)-6-(4-(4- meth...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)C#N)nc1
Show InChI InChI=1S/C32H27N5O5/c1-41-26-10-4-22(5-11-26)30(38)23-14-16-37(17-15-23)32(40)28-12-6-24(19-34-28)31(39)36-25-7-13-29(35-20-25)42-27-8-2-21(18-33)3-9-27/h2-13,19-20,23H,14-17H2,1H3,(H,36,39)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM409435
PNG
(N-((cis)-3-fluoro-1-(4- (trifluoromethoxy)benzyl)p...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@@H]1CCN(Cc2ccc(OC(F)(F)F)cc2)C[C@@H]1F
Show InChI InChI=1S/C33H34F4N4O5/c1-45-25-9-4-22(5-10-25)30(42)23-12-16-41(17-13-23)32(44)29-11-6-24(18-38-29)31(43)39-28-14-15-40(20-27(28)34)19-21-2-7-26(8-3-21)46-33(35,36)37/h2-11,18,23,27-28H,12-17,19-20H2,1H3,(H,39,43)/t27-,28+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328324
PNG
(N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(4- met...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)C(C)=O)nc1
Show InChI InChI=1S/C33H30N4O6/c1-21(38)22-3-11-28(12-4-22)43-30-14-8-26(20-35-30)36-32(40)25-7-13-29(34-19-25)33(41)37-17-15-24(16-18-37)31(39)23-5-9-27(42-2)10-6-23/h3-14,19-20,24H,15-18H2,1-2H3,(H,36,40)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328325
PNG
(N-(6-(4- cyanophenoxy)pyridin- 3-yl)-6-(4-(2,4- di...)
Show SMILES Fc1ccc(C(=O)C2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)nc2)c(F)c1
Show InChI InChI=1S/C31H23F2N5O4/c32-22-4-8-25(26(33)15-22)29(39)20-11-13-38(14-12-20)31(41)27-9-3-21(17-35-27)30(40)37-23-5-10-28(36-18-23)42-24-6-1-19(16-34)2-7-24/h1-10,15,17-18,20H,11-14H2,(H,37,40)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM328326
PNG
(N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(2,4- d...)
Show SMILES CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)cc3F)cn2)cc1
Show InChI InChI=1S/C32H26F2N4O5/c1-19(39)20-2-7-25(8-3-20)43-29-11-6-24(18-36-29)37-31(41)22-4-10-28(35-17-22)32(42)38-14-12-21(13-15-38)30(40)26-9-5-23(33)16-27(26)34/h2-11,16-18,21H,12-15H2,1H3,(H,37,41)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 1136 total )  |  Next  |  Last  >>
Jump to: