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Compile Data Set for Download or QSAR

Found 1553 hits Enz. Inhib. hit(s) with Target = 'Angiotensin II type 1a (AT-1a) receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50282221
PNG
(2-Ethyl-4-hydroxy-5-phenyl-7-[2'-(1H-tetrazol-5-yl...)
Show SMILES CCc1cc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2s1
Show InChI InChI=1S/C29H23N5O2S/c1-2-21-16-24-26(35)25(20-8-4-3-5-9-20)28(36)34(29(24)37-21)17-18-12-14-19(15-13-18)22-10-6-7-11-23(22)27-30-32-33-31-27/h3-16,35H,2,17H2,1H3,(H,30,31,32,33)
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n/an/an/an/a 90n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125I]-AII binding to angiotensin II receptor of bovine adrenal cortex


Bioorg Med Chem Lett 4: 127-132 (1994)


Article DOI: 10.1016/S0960-894X(01)81134-3
BindingDB Entry DOI: 10.7270/Q2VD6ZC9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50009714
PNG
(CHEMBL191 | {2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5...)
Show SMILES CCCCC1=NC(Cl)C(CO)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H25ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,19,21,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/an/an/a 350n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125I]-AII binding to angiotensin II receptor of bovine adrenal cortex


Bioorg Med Chem Lett 4: 127-132 (1994)


Article DOI: 10.1016/S0960-894X(01)81134-3
BindingDB Entry DOI: 10.7270/Q2VD6ZC9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50282222
PNG
(7-Ethoxy-4-hydroxy-3-phenyl-1-[2'-(1H-tetrazol-5-y...)
Show SMILES CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2c1
Show InChI InChI=1S/C31H25N5O3/c1-2-39-23-16-17-26-27(18-23)36(31(38)28(29(26)37)22-8-4-3-5-9-22)19-20-12-14-21(15-13-20)24-10-6-7-11-25(24)30-32-34-35-33-30/h3-18,37H,2,19H2,1H3,(H,32,33,34,35)
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n/an/an/an/a 500n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125I]-AII binding to angiotensin II receptor of bovine adrenal cortex


Bioorg Med Chem Lett 4: 127-132 (1994)


Article DOI: 10.1016/S0960-894X(01)81134-3
BindingDB Entry DOI: 10.7270/Q2VD6ZC9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50282218
PNG
(4-Hydroxy-7-methylsulfanyl-3-phenyl-1-[2'-(1H-tetr...)
Show SMILES CSc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2c1
Show InChI InChI=1S/C30H23N5O2S/c1-38-22-15-16-25-26(17-22)35(30(37)27(28(25)36)21-7-3-2-4-8-21)18-19-11-13-20(14-12-19)23-9-5-6-10-24(23)29-31-33-34-32-29/h2-17,36H,18H2,1H3,(H,31,32,33,34)
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n/an/an/an/a 600n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125I]-AII binding to angiotensin II receptor of bovine adrenal cortex


Bioorg Med Chem Lett 4: 127-132 (1994)


Article DOI: 10.1016/S0960-894X(01)81134-3
BindingDB Entry DOI: 10.7270/Q2VD6ZC9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50282215
PNG
(4-Hydroxy-3-phenyl-1-[2'-(1H-tetrazol-5-yl)-biphen...)
Show SMILES Oc1c2CCCc2n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(=O)c1-c1ccccc1
Show InChI InChI=1S/C28H23N5O2/c34-26-23-11-6-12-24(23)33(28(35)25(26)20-7-2-1-3-8-20)17-18-13-15-19(16-14-18)21-9-4-5-10-22(21)27-29-31-32-30-27/h1-5,7-10,13-16,34H,6,11-12,17H2,(H,29,30,31,32)
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n/an/an/an/a 1.25E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125I]-AII binding to angiotensin II receptor of bovine adrenal cortex


Bioorg Med Chem Lett 4: 127-132 (1994)


Article DOI: 10.1016/S0960-894X(01)81134-3
BindingDB Entry DOI: 10.7270/Q2VD6ZC9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50282219
PNG
(4-Hydroxy-7-methyl-3-phenyl-1-[2'-(1H-tetrazol-5-y...)
Show SMILES Cc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2n1
Show InChI InChI=1S/C29H22N6O2/c1-18-11-16-24-26(36)25(21-7-3-2-4-8-21)29(37)35(28(24)30-18)17-19-12-14-20(15-13-19)22-9-5-6-10-23(22)27-31-33-34-32-27/h2-16,36H,17H2,1H3,(H,31,32,33,34)
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n/an/an/an/a 1.25E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125I]-AII binding to angiotensin II receptor of bovine adrenal cortex


Bioorg Med Chem Lett 4: 127-132 (1994)


Article DOI: 10.1016/S0960-894X(01)81134-3
BindingDB Entry DOI: 10.7270/Q2VD6ZC9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50282217
PNG
(4-Hydroxy-3-phenyl-1-[2'-(1H-tetrazol-5-yl)-biphen...)
Show SMILES Oc1c(-c2ccccc2)c(=O)n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ccccc12
Show InChI InChI=1S/C29H21N5O2/c35-27-24-12-6-7-13-25(24)34(29(36)26(27)21-8-2-1-3-9-21)18-19-14-16-20(17-15-19)22-10-4-5-11-23(22)28-30-32-33-31-28/h1-17,35H,18H2,(H,30,31,32,33)
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n/an/an/an/a 1.70E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125I]-AII binding to angiotensin II receptor of bovine adrenal cortex


Bioorg Med Chem Lett 4: 127-132 (1994)


Article DOI: 10.1016/S0960-894X(01)81134-3
BindingDB Entry DOI: 10.7270/Q2VD6ZC9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50282216
PNG
(4'-(7-Ethoxy-4-hydroxy-2-oxo-3-phenyl-2H-quinolin-...)
Show SMILES CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(cc3)-c3ccccc3C(O)=O)c2c1
Show InChI InChI=1S/C31H25NO5/c1-2-37-23-16-17-26-27(18-23)32(30(34)28(29(26)33)22-8-4-3-5-9-22)19-20-12-14-21(15-13-20)24-10-6-7-11-25(24)31(35)36/h3-18,33H,2,19H2,1H3,(H,35,36)
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n/an/an/an/a 1.80E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125I]-AII binding to angiotensin II receptor of bovine adrenal cortex


Bioorg Med Chem Lett 4: 127-132 (1994)


Article DOI: 10.1016/S0960-894X(01)81134-3
BindingDB Entry DOI: 10.7270/Q2VD6ZC9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50282223
PNG
(4-Hydroxy-7-methoxy-3-phenyl-1-[2'-(1H-tetrazol-5-...)
Show SMILES COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2c1
Show InChI InChI=1S/C30H23N5O3/c1-38-22-15-16-25-26(17-22)35(30(37)27(28(25)36)21-7-3-2-4-8-21)18-19-11-13-20(14-12-19)23-9-5-6-10-24(23)29-31-33-34-32-29/h2-17,36H,18H2,1H3,(H,31,32,33,34)
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n/an/an/an/a 2.20E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125I]-AII binding to angiotensin II receptor of bovine adrenal cortex


Bioorg Med Chem Lett 4: 127-132 (1994)


Article DOI: 10.1016/S0960-894X(01)81134-3
BindingDB Entry DOI: 10.7270/Q2VD6ZC9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50003399
PNG
(4'-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl...)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H23ClN2O3/c1-2-3-8-20-24-21(23)19(14-26)25(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22(27)28/h4-7,9-12,26H,2-3,8,13-14H2,1H3,(H,27,28)
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n/an/an/an/a 2.70E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125I]-AII binding to angiotensin II receptor of bovine adrenal cortex


Bioorg Med Chem Lett 4: 127-132 (1994)


Article DOI: 10.1016/S0960-894X(01)81134-3
BindingDB Entry DOI: 10.7270/Q2VD6ZC9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50282214
PNG
(7-Hydroxy-6-phenyl-4-[2'-(1H-tetrazol-5-yl)-biphen...)
Show SMILES Oc1c(-c2ccccc2)c(=O)n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ccsc12
Show InChI InChI=1S/C27H19N5O2S/c33-24-23(19-6-2-1-3-7-19)27(34)32(22-14-15-35-25(22)24)16-17-10-12-18(13-11-17)20-8-4-5-9-21(20)26-28-30-31-29-26/h1-15,33H,16H2,(H,28,29,30,31)
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n/an/an/an/a 6.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125I]-AII binding to angiotensin II receptor of bovine adrenal cortex


Bioorg Med Chem Lett 4: 127-132 (1994)


Article DOI: 10.1016/S0960-894X(01)81134-3
BindingDB Entry DOI: 10.7270/Q2VD6ZC9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50282220
PNG
(4'-(4-Hydroxy-7-methoxy-2-oxo-3-phenyl-2H-quinolin...)
Show SMILES COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(cc3)-c3ccccc3C(O)=O)c2c1
Show InChI InChI=1S/C30H23NO5/c1-36-22-15-16-25-26(17-22)31(29(33)27(28(25)32)21-7-3-2-4-8-21)18-19-11-13-20(14-12-19)23-9-5-6-10-24(23)30(34)35/h2-17,32H,18H2,1H3,(H,34,35)
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n/an/an/an/a 9.50E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125I]-AII binding to angiotensin II receptor of bovine adrenal cortex


Bioorg Med Chem Lett 4: 127-132 (1994)


Article DOI: 10.1016/S0960-894X(01)81134-3
BindingDB Entry DOI: 10.7270/Q2VD6ZC9
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50240609
PNG
(2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...)
Show SMILES CCOc1nc2cccc(C(O)=O)c2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29)
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0.640n/an/an/an/an/an/an/an/a



DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibitory activity against Angiotensin II receptor, type 1 in rat adrenal membrane


J Med Chem 39: 625-56 (1996)


Article DOI: 10.1021/jm9504722
BindingDB Entry DOI: 10.7270/Q29P3299
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50044518
PNG
(5-Butyl-2-(2-nitro-phenyl)-4-[2'-(1H-tetrazol-5-yl...)
Show SMILES CCCCc1nn(-c2ccccc2[N+]([O-])=O)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C26H24N8O3/c1-2-3-12-24-29-33(22-10-6-7-11-23(22)34(36)37)26(35)32(24)17-18-13-15-19(16-14-18)20-8-4-5-9-21(20)25-27-30-31-28-25/h4-11,13-16H,2-3,12,17H2,1H3,(H,27,28,30,31)
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0.850n/an/an/an/an/an/an/an/a



NeoGenesis, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Angiotensin II receptor, type 1


J Med Chem 43: 1993-2006 (2000)


Article DOI: 10.1021/jm990504b
BindingDB Entry DOI: 10.7270/Q2MP53ZS
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50241491
PNG
(2-{4-Butyl-2-methyl-6-oxo-5-[2'-(1H-tetrazol-5-yl)...)
Show SMILES CCCCc1nc(C)n(Cc2sccc2C(=O)OC)c(=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C30H30N6O3S/c1-4-5-10-26-25(29(37)36(19(2)31-26)18-27-24(15-16-40-27)30(38)39-3)17-20-11-13-21(14-12-20)22-8-6-7-9-23(22)28-32-34-35-33-28/h6-9,11-16H,4-5,10,17-18H2,1-3H3,(H,32,33,34,35)
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0.900n/an/an/an/an/an/an/an/a



DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Binding affinity was evaluated towards Angiotensin II receptor, type 1 in rabbit aorta


J Med Chem 39: 625-56 (1996)


Article DOI: 10.1021/jm9504722
BindingDB Entry DOI: 10.7270/Q29P3299
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035431
PNG
(5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Show SMILES CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C27H24F3N7O/c1-2-3-12-24-33-37(23-11-7-6-10-22(23)27(28,29)30)26(38)36(24)17-18-13-15-19(16-14-18)20-8-4-5-9-21(20)25-31-34-35-32-25/h4-11,13-16H,2-3,12,17H2,1H3,(H,31,32,34,35)
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1.20n/an/an/an/an/an/an/an/a



NeoGenesis, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Angiotensin II receptor, type 1


J Med Chem 43: 1993-2006 (2000)


Article DOI: 10.1021/jm990504b
BindingDB Entry DOI: 10.7270/Q2MP53ZS
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50044543
PNG
(5-Butyl-2-(2-isopropyl-phenyl)-4-[2'-(1H-tetrazol-...)
Show SMILES CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C29H31N7O/c1-4-5-14-27-32-36(26-13-9-8-10-23(26)20(2)3)29(37)35(27)19-21-15-17-22(18-16-21)24-11-6-7-12-25(24)28-30-33-34-31-28/h6-13,15-18,20H,4-5,14,19H2,1-3H3,(H,30,31,33,34)
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1.40n/an/an/an/an/an/an/an/a



NeoGenesis, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Angiotensin II receptor, type 1


J Med Chem 43: 1993-2006 (2000)


Article DOI: 10.1021/jm990504b
BindingDB Entry DOI: 10.7270/Q2MP53ZS
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029911
PNG
(2-{4-Butyl-2-methyl-6-oxo-5-[2'-(1H-tetrazol-5-yl)...)
Show SMILES CCCCc1nc(C)n(Cc2ccccc2C(O)=O)c(=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C31H30N6O3/c1-3-4-13-28-27(30(38)37(20(2)32-28)19-23-9-5-6-11-25(23)31(39)40)18-21-14-16-22(17-15-21)24-10-7-8-12-26(24)29-33-35-36-34-29/h5-12,14-17H,3-4,13,18-19H2,1-2H3,(H,39,40)(H,33,34,35,36)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029903
PNG
(3-Benzyl-6-butyl-2-methyl-5-[2'-(1H-tetrazol-5-yl)...)
Show SMILES CCCCc1nc(C)n(Cc2ccccc2)c(=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C30H30N6O/c1-3-4-14-28-27(30(37)36(21(2)31-28)20-23-10-6-5-7-11-23)19-22-15-17-24(18-16-22)25-12-8-9-13-26(25)29-32-34-35-33-29/h5-13,15-18H,3-4,14,19-20H2,1-2H3,(H,32,33,34,35)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029910
PNG
(4'-(4-Butyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl...)
Show SMILES CCCCc1nc[nH]c(=O)c1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H22N2O3/c1-2-3-8-20-19(21(25)24-14-23-20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22(26)27/h4-7,9-12,14H,2-3,8,13H2,1H3,(H,26,27)(H,23,24,25)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029909
PNG
(4'-[4-Butyl-1-(2-carboxy-benzyl)-6-oxo-1,6-dihydro...)
Show SMILES CCCCc1ncn(Cc2ccccc2C(O)=O)c(=O)c1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C30H28N2O5/c1-2-3-12-27-26(28(33)32(19-31-27)18-22-8-4-5-10-24(22)29(34)35)17-20-13-15-21(16-14-20)23-9-6-7-11-25(23)30(36)37/h4-11,13-16,19H,2-3,12,17-18H2,1H3,(H,34,35)(H,36,37)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029906
PNG
(2-[4-Butyl-5-(2'-carboxy-biphenyl-4-ylmethyl)-2-me...)
Show SMILES CCCCc1nc(C)n(Cc2sccc2C(O)=O)c(=O)c1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C29H28N2O5S/c1-3-4-9-25-24(27(32)31(18(2)30-25)17-26-23(29(35)36)14-15-37-26)16-19-10-12-20(13-11-19)21-7-5-6-8-22(21)28(33)34/h5-8,10-15H,3-4,9,16-17H2,1-2H3,(H,33,34)(H,35,36)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029893
PNG
(2-[4-Butyl-5-(2'-carboxy-biphenyl-4-ylmethyl)-2-me...)
Show SMILES CCCCc1nc(C)n(Cc2occc2C(O)=O)c(=O)c1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C29H28N2O6/c1-3-4-9-25-24(27(32)31(18(2)30-25)17-26-23(29(35)36)14-15-37-26)16-19-10-12-20(13-11-19)21-7-5-6-8-22(21)28(33)34/h5-8,10-15H,3-4,9,16-17H2,1-2H3,(H,33,34)(H,35,36)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029908
PNG
(4'-(4-Butyl-6-oxo-1-thiophen-2-ylmethyl-1,6-dihydr...)
Show SMILES CCCCc1ncn(Cc2cccs2)c(=O)c1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C27H26N2O3S/c1-2-3-10-25-24(26(30)29(18-28-25)17-21-7-6-15-33-21)16-19-11-13-20(14-12-19)22-8-4-5-9-23(22)27(31)32/h4-9,11-15,18H,2-3,10,16-17H2,1H3,(H,31,32)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029899
PNG
(3-{4-Butyl-2-methyl-6-oxo-5-[2'-(1H-tetrazol-5-yl)...)
Show SMILES CCCCc1nc(C)n(Cc2ccsc2C(=O)OC)c(=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C30H30N6O3S/c1-4-5-10-26-25(29(37)36(19(2)31-26)18-22-15-16-40-27(22)30(38)39-3)17-20-11-13-21(14-12-20)23-8-6-7-9-24(23)28-32-34-35-33-28/h6-9,11-16H,4-5,10,17-18H2,1-3H3,(H,32,33,34,35)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029905
PNG
(4'-(2-Butyl-4-methyl-6-oxo-6H-pyrimidin-1-ylmethyl...)
Show SMILES CCCCc1nc(C)cc(=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C23H24N2O3/c1-3-4-9-21-24-16(2)14-22(26)25(21)15-17-10-12-18(13-11-17)19-7-5-6-8-20(19)23(27)28/h5-8,10-14H,3-4,9,15H2,1-2H3,(H,27,28)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029895
PNG
(2-{4-Butyl-2-methyl-6-oxo-5-[2'-(1H-tetrazol-5-yl)...)
Show SMILES CCCCc1nc(C)n(Cc2occc2C(O)=O)c(=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C29H28N6O4/c1-3-4-9-25-24(28(36)35(18(2)30-25)17-26-23(29(37)38)14-15-39-26)16-19-10-12-20(13-11-19)21-7-5-6-8-22(21)27-31-33-34-32-27/h5-8,10-15H,3-4,9,16-17H2,1-2H3,(H,37,38)(H,31,32,33,34)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029894
PNG
(4'-(4-Butyl-2-methyl-6-oxo-1,6-dihydro-pyrimidin-5...)
Show SMILES CCCCc1nc(C)[nH]c(=O)c1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C23H24N2O3/c1-3-4-9-21-20(22(26)25-15(2)24-21)14-16-10-12-17(13-11-16)18-7-5-6-8-19(18)23(27)28/h5-8,10-13H,3-4,9,14H2,1-2H3,(H,27,28)(H,24,25,26)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029904
PNG
(4'-[4-Butyl-1-(2-carboxy-benzyl)-2-methyl-6-oxo-1,...)
Show SMILES CCCCc1nc(C)n(Cc2ccccc2C(O)=O)c(=O)c1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C31H30N2O5/c1-3-4-13-28-27(18-21-14-16-22(17-15-21)24-10-7-8-12-26(24)31(37)38)29(34)33(20(2)32-28)19-23-9-5-6-11-25(23)30(35)36/h5-12,14-17H,3-4,13,18-19H2,1-2H3,(H,35,36)(H,37,38)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029902
PNG
(6-Butyl-2-methyl-5-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nc(C)[nH]c(=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H24N6O/c1-3-4-9-21-20(23(30)25-15(2)24-21)14-16-10-12-17(13-11-16)18-7-5-6-8-19(18)22-26-28-29-27-22/h5-8,10-13H,3-4,9,14H2,1-2H3,(H,24,25,30)(H,26,27,28,29)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029897
PNG
(4'-[4-Butyl-1-(4-carboxy-benzyl)-6-oxo-1,6-dihydro...)
Show SMILES CCCCc1ncn(Cc2ccc(cc2)C(O)=O)c(=O)c1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C30H28N2O5/c1-2-3-8-27-26(28(33)32(19-31-27)18-21-11-15-23(16-12-21)29(34)35)17-20-9-13-22(14-10-20)24-6-4-5-7-25(24)30(36)37/h4-7,9-16,19H,2-3,8,17-18H2,1H3,(H,34,35)(H,36,37)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029901
PNG
(2-{4-Butyl-2-methyl-6-oxo-5-[2'-(1H-tetrazol-5-yl)...)
Show SMILES CCCCc1nc(C)n(Cc2occc2C(=O)OC)c(=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C30H30N6O4/c1-4-5-10-26-25(29(37)36(19(2)31-26)18-27-24(15-16-40-27)30(38)39-3)17-20-11-13-21(14-12-20)22-8-6-7-9-23(22)28-32-34-35-33-28/h6-9,11-16H,4-5,10,17-18H2,1-3H3,(H,32,33,34,35)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029892
PNG
(2-{4-Butyl-2-methyl-6-oxo-5-[2'-(1H-tetrazol-5-yl)...)
Show SMILES CCCCc1nc(C)n(Cc2sccc2C(O)=O)c(=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C29H28N6O3S/c1-3-4-9-25-24(28(36)35(18(2)30-25)17-26-23(29(37)38)14-15-39-26)16-19-10-12-20(13-11-19)21-7-5-6-8-22(21)27-31-33-34-32-27/h5-8,10-15H,3-4,9,16-17H2,1-2H3,(H,37,38)(H,31,32,33,34)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50241501
PNG
(6-Butyl-2-methyl-5-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nc(C)n(Cc2cccs2)c(=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C28H28N6OS/c1-3-4-11-26-25(28(35)34(19(2)29-26)18-22-8-7-16-36-22)17-20-12-14-21(15-13-20)23-9-5-6-10-24(23)27-30-32-33-31-27/h5-10,12-16H,3-4,11,17-18H2,1-2H3,(H,30,31,32,33)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50241491
PNG
(2-{4-Butyl-2-methyl-6-oxo-5-[2'-(1H-tetrazol-5-yl)...)
Show SMILES CCCCc1nc(C)n(Cc2sccc2C(=O)OC)c(=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C30H30N6O3S/c1-4-5-10-26-25(29(37)36(19(2)31-26)18-27-24(15-16-40-27)30(38)39-3)17-20-11-13-21(14-12-20)22-8-6-7-9-23(22)28-32-34-35-33-28/h6-9,11-16H,4-5,10,17-18H2,1-3H3,(H,32,33,34,35)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029896
PNG
(4'-(2-Butyl-6-oxo-6H-pyrimidin-1-ylmethyl)-bipheny...)
Show SMILES CCCCc1nccc(=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H22N2O3/c1-2-3-8-20-23-14-13-21(25)24(20)15-16-9-11-17(12-10-16)18-6-4-5-7-19(18)22(26)27/h4-7,9-14H,2-3,8,15H2,1H3,(H,26,27)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50029907
PNG
(4'-(1-Benzyl-4-butyl-6-oxo-1,6-dihydro-pyrimidin-5...)
Show SMILES CCCCc1ncn(Cc2ccccc2)c(=O)c1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C29H28N2O3/c1-2-3-13-27-26(28(32)31(20-30-27)19-22-9-5-4-6-10-22)18-21-14-16-23(17-15-21)24-11-7-8-12-25(24)29(33)34/h4-12,14-17,20H,2-3,13,18-19H2,1H3,(H,33,34)
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>4n/an/an/an/an/an/an/an/a



Istituto Lusofarmaco

Curated by ChEMBL


Assay Description
Binding affinity towards Angiotensin II type 2 receptor in bovine cerebellar cortical membranes; Inactive


J Med Chem 38: 4806-20 (1996)


Article DOI: 10.1021/jm00024a008
BindingDB Entry DOI: 10.7270/Q2JQ101N
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50035429
PNG
(4'-[2-Butyl-6-(3-cyclohexyl-ureido)-benzoimidazol-...)
Show SMILES CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C32H36N4O3/c1-2-3-13-30-35-28-19-18-25(34-32(39)33-24-9-5-4-6-10-24)20-29(28)36(30)21-22-14-16-23(17-15-22)26-11-7-8-12-27(26)31(37)38/h7-8,11-12,14-20,24H,2-6,9-10,13,21H2,1H3,(H,37,38)(H2,33,34,39)
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29n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a...


J Med Chem 37: 4464-78 (1995)


Article DOI: 10.1021/jm00052a006
BindingDB Entry DOI: 10.7270/Q2WD3ZK5
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Synthélabo Recherche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 280: 83-97 (1997)


BindingDB Entry DOI: 10.7270/Q2NZ865X
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM22869
PNG
(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Show SMILES CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Synthélabo Recherche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 280: 83-97 (1997)


BindingDB Entry DOI: 10.7270/Q2NZ865X
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM81790
PNG
(Amisulpride | CAS_71675-85-9 | NSC_2159)
Show SMILES CCN1CCCC1CNC(=O)c1cc(c(N)cc1OC)S(=O)(=O)CC
Show InChI InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21)
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>1.00E+4n/an/an/an/an/an/an/an/a



Synthélabo Recherche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 280: 83-97 (1997)


BindingDB Entry DOI: 10.7270/Q2NZ865X
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282616
PNG
(6-{2-Cyclopropyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES Cc1cc(=O)[nH]nc1-c1ccc2nc(C3CC3)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2c1
Show InChI InChI=1S/C29H24N8O/c1-17-14-26(38)31-32-27(17)21-12-13-24-25(15-21)37(29(30-24)20-10-11-20)16-18-6-8-19(9-7-18)22-4-2-3-5-23(22)28-33-35-36-34-28/h2-9,12-15,20H,10-11,16H2,1H3,(H,31,38)(H,33,34,35,36)
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n/an/a 3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings


Bioorg Med Chem Lett 4: 1297-1302 (1994)


Article DOI: 10.1016/S0960-894X(01)80348-6
BindingDB Entry DOI: 10.7270/Q2G44QRD
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM82258
PNG
(CAS_114798-26-4 | Losartan | NSC_3961)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings


Bioorg Med Chem Lett 4: 1297-1302 (1994)


Article DOI: 10.1016/S0960-894X(01)80348-6
BindingDB Entry DOI: 10.7270/Q2G44QRD
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282613
PNG
(6-{2-Cyclopropyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2c1
Show InChI InChI=1S/C29H26N8O/c1-17-14-26(38)31-32-27(17)21-12-13-24-25(15-21)37(29(30-24)20-10-11-20)16-18-6-8-19(9-7-18)22-4-2-3-5-23(22)28-33-35-36-34-28/h2-9,12-13,15,17,20H,10-11,14,16H2,1H3,(H,31,38)(H,33,34,35,36)
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n/an/a 2n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings


Bioorg Med Chem Lett 4: 1297-1302 (1994)


Article DOI: 10.1016/S0960-894X(01)80348-6
BindingDB Entry DOI: 10.7270/Q2G44QRD
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282611
PNG
((3-{2-Cyclopropyl-3-[2'-(1H-tetrazol-5-yl)-bipheny...)
Show SMILES COC(=O)CN1N=C(C(C)CC1=O)c1ccc2nc(C3CC3)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2c1
Show InChI InChI=1S/C32H30N8O3/c1-19-15-28(41)40(18-29(42)43-2)36-30(19)23-13-14-26-27(16-23)39(32(33-26)22-11-12-22)17-20-7-9-21(10-8-20)24-5-3-4-6-25(24)31-34-37-38-35-31/h3-10,13-14,16,19,22H,11-12,15,17-18H2,1-2H3,(H,34,35,37,38)
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n/an/a 4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings


Bioorg Med Chem Lett 4: 1297-1302 (1994)


Article DOI: 10.1016/S0960-894X(01)80348-6
BindingDB Entry DOI: 10.7270/Q2G44QRD
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282709
PNG
(Benzyl-{2-butyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-bip...)
Show SMILES CCCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(Cc1ccccc1)C(=O)OCC(C)C
Show InChI InChI=1S/C38H39N7O3/c1-4-5-15-35-39-34-21-20-30(44(38(47)48-25-26(2)3)23-27-11-7-6-8-12-27)22-33(34)37(46)45(35)24-28-16-18-29(19-17-28)31-13-9-10-14-32(31)36-40-42-43-41-36/h6-14,16-22,26H,4-5,15,23-25H2,1-3H3,(H,40,41,42,43)
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n/an/a 5.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane


Bioorg Med Chem Lett 4: 1479-1484 (1994)


Article DOI: 10.1016/S0960-894X(01)80517-5
BindingDB Entry DOI: 10.7270/Q2BC401G
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282705
PNG
(CHEMBL290669 | N-Benzyl-N-{2-isopropyl-4-oxo-3-[2'...)
Show SMILES CC(C)c1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(Cc1ccccc1)C(=O)c1ccccc1
Show InChI InChI=1S/C39H33N7O2/c1-26(2)37-40-35-22-21-31(45(24-27-11-5-3-6-12-27)38(47)30-13-7-4-8-14-30)23-34(35)39(48)46(37)25-28-17-19-29(20-18-28)32-15-9-10-16-33(32)36-41-43-44-42-36/h3-23,26H,24-25H2,1-2H3,(H,41,42,43,44)
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n/an/a 1.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane


Bioorg Med Chem Lett 4: 1479-1484 (1994)


Article DOI: 10.1016/S0960-894X(01)80517-5
BindingDB Entry DOI: 10.7270/Q2BC401G
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282710
PNG
(CHEMBL34082 | N-Benzyl-N-{2-ethyl-4-oxo-3-[2'-(1H-...)
Show SMILES CCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(Cc1ccccc1)C(=O)c1ccccc1
Show InChI InChI=1S/C38H31N7O2/c1-2-35-39-34-22-21-30(44(24-26-11-5-3-6-12-26)37(46)29-13-7-4-8-14-29)23-33(34)38(47)45(35)25-27-17-19-28(20-18-27)31-15-9-10-16-32(31)36-40-42-43-41-36/h3-23H,2,24-25H2,1H3,(H,40,41,42,43)
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n/an/a 72n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane


Bioorg Med Chem Lett 4: 1479-1484 (1994)


Article DOI: 10.1016/S0960-894X(01)80517-5
BindingDB Entry DOI: 10.7270/Q2BC401G
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282706
PNG
(CHEMBL276853 | N-{2-Ethyl-4-oxo-3-[2'-(1H-tetrazol...)
Show SMILES CCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(CC=C(C)C)C(=O)c1ccccc1
Show InChI InChI=1S/C36H33N7O2/c1-4-33-37-32-19-18-28(42(21-20-24(2)3)35(44)27-10-6-5-7-11-27)22-31(32)36(45)43(33)23-25-14-16-26(17-15-25)29-12-8-9-13-30(29)34-38-40-41-39-34/h5-20,22H,4,21,23H2,1-3H3,(H,38,39,40,41)
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n/an/a 79n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane


Bioorg Med Chem Lett 4: 1479-1484 (1994)


Article DOI: 10.1016/S0960-894X(01)80517-5
BindingDB Entry DOI: 10.7270/Q2BC401G
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282703
PNG
(CHEMBL35638 | N-Benzyl-N-{2-ethyl-4-oxo-3-[2'-(1H-...)
Show SMILES CCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(Cc1ccccc1)C(=O)c1ccncc1
Show InChI InChI=1S/C37H30N8O2/c1-2-34-39-33-17-16-29(44(23-25-8-4-3-5-9-25)36(46)28-18-20-38-21-19-28)22-32(33)37(47)45(34)24-26-12-14-27(15-13-26)30-10-6-7-11-31(30)35-40-42-43-41-35/h3-22H,2,23-24H2,1H3,(H,40,41,42,43)
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n/an/a 170n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane


Bioorg Med Chem Lett 4: 1479-1484 (1994)


Article DOI: 10.1016/S0960-894X(01)80517-5
BindingDB Entry DOI: 10.7270/Q2BC401G
More data for this
Ligand-Target Pair
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