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Compile Data Set for Download or QSAR

Found 5396 hits Enz. Inhib. hit(s) with Target = 'Apelin receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270203
PNG
((1R,2S,P)—N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C24H28N8O6S/c1-14-12-26-21(27-13-14)20(37-5)15(2)39(33,34)31-24-30-29-22(16-8-7-9-18(28-16)36-4)32(24)19-17(35-3)10-11-25-23(19)38-6/h7-13,15,20H,1-6H3,(H,30,31)/t15-,20-/m0/s1
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n/an/an/an/a 0.0320n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)


BindingDB Entry DOI: 10.7270/Q28P62TV
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270203
PNG
((1R,2S,P)—N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C24H28N8O6S/c1-14-12-26-21(27-13-14)20(37-5)15(2)39(33,34)31-24-30-29-22(16-8-7-9-18(28-16)36-4)32(24)19-17(35-3)10-11-25-23(19)38-6/h7-13,15,20H,1-6H3,(H,30,31)/t15-,20-/m0/s1
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n/an/an/an/a 0.0320n/an/a7.5n/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270203
PNG
((1R,2S,P)—N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C24H28N8O6S/c1-14-12-26-21(27-13-14)20(37-5)15(2)39(33,34)31-24-30-29-22(16-8-7-9-18(28-16)36-4)32(24)19-17(35-3)10-11-25-23(19)38-6/h7-13,15,20H,1-6H3,(H,30,31)/t15-,20-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM50078006
PNG
(CHEMBL3417385)
Show SMILES CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)C(=O)c1ccccc1)C(O)=O
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n/an/an/an/a 0.0400n/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated ...


J Med Chem 58: 2431-40 (2015)


Article DOI: 10.1021/jm501916k
BindingDB Entry DOI: 10.7270/Q21V5GNR
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM50014619
PNG
(CHEMBL3184840)
Show SMILES CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C69H108N22O16S/c1-39(2)32-47(85-57(96)43(17-9-26-76-68(71)72)82-63(102)52-20-12-29-90(52)65(104)45(18-10-27-77-69(73)74)83-58(97)44-22-23-54(93)80-44)59(98)88-50(37-92)61(100)86-48(34-41-35-75-38-79-41)60(99)81-42(16-7-8-25-70)56(95)78-36-55(94)89-28-11-19-51(89)62(101)84-46(24-31-108-3)66(105)91-30-13-21-53(91)64(103)87-49(67(106)107)33-40-14-5-4-6-15-40/h4-6,14-15,35,38-39,42-53,92H,7-13,16-34,36-37,70H2,1-3H3,(H,75,79)(H,78,95)(H,80,93)(H,81,99)(H,82,102)(H,83,97)(H,84,101)(H,85,96)(H,86,100)(H,87,103)(H,88,98)(H,106,107)(H4,71,72,76)(H4,73,74,77)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-/m0/s1
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n/an/an/an/a 0.0470n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Agonist activity at human APJ-R expressed in HEK293 cells assessed as inhibition of forskolin- stimulated cAMP accumulation incubated for 30 mins by ...


J Med Chem 62: 10456-10465 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01513
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM448014
PNG
(US10689367, Example 342.0 | US10689367, Example 34...)
Show SMILES CC[C@H](c1cc(F)cc(F)c1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1
Show InChI InChI=1S/C25H26ClF2N7O4S/c1-5-20(15-9-17(27)11-18(28)10-15)35-24(19-7-6-8-21(31-19)38-3)32-33-25(35)34-40(36,37)14(2)22(39-4)23-29-12-16(26)13-30-23/h6-14,20,22H,5H2,1-4H3,(H,33,34)/t14-,20+,22-/m0/s1
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n/an/an/an/a 0.0500n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM456669
PNG
(US10736883, Example 116.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(C)o2)n1-c1c(OC)cccc1OC)c1ncc(F)cn1
Show InChI InChI=1S/C23H25FN6O6S/c1-13-9-10-18(36-13)22-27-28-23(30(22)19-16(33-3)7-6-8-17(19)34-4)29-37(31,32)14(2)20(35-5)21-25-11-15(24)12-26-21/h6-12,14,20H,1-5H3,(H,28,29)/t14-,20-/m0/s1
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n/an/an/an/a 0.0560n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10736883 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM456867
PNG
(US10736883, Example 383.0)
Show SMILES COc1ncnc(OC)c1\N=C(\NNC(=O)c1ccc(C)o1)NS(=O)(=O)[C@@H](C)[C@H](C)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H25ClN8O6S/c1-11-6-7-15(36-11)18(31)28-29-21(27-16-19(34-4)25-10-26-20(16)35-5)30-37(32,33)13(3)12(2)17-23-8-14(22)9-24-17/h6-10,12-13H,1-5H3,(H,28,31)(H2,27,29,30)/t12-,13-/m0/s1
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n/an/an/an/a 0.0600n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10736883 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM456670
PNG
(US10736883, Example 117.0)
Show SMILES CCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(C)o2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H30N6O6S/c1-7-36-22(23-26-13-15(2)14-27-23)17(4)38(32,33)30-25-29-28-24(20-12-11-16(3)37-20)31(25)21-18(34-5)9-8-10-19(21)35-6/h8-14,17,22H,7H2,1-6H3,(H,29,30)/t17-,22+/m0/s1
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n/an/an/an/a 0.0610n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10736883 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Rattus norvegicus)
BDBM50014619
PNG
(CHEMBL3184840)
Show SMILES CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C69H108N22O16S/c1-39(2)32-47(85-57(96)43(17-9-26-76-68(71)72)82-63(102)52-20-12-29-90(52)65(104)45(18-10-27-77-69(73)74)83-58(97)44-22-23-54(93)80-44)59(98)88-50(37-92)61(100)86-48(34-41-35-75-38-79-41)60(99)81-42(16-7-8-25-70)56(95)78-36-55(94)89-28-11-19-51(89)62(101)84-46(24-31-108-3)66(105)91-30-13-21-53(91)64(103)87-49(67(106)107)33-40-14-5-4-6-15-40/h4-6,14-15,35,38-39,42-53,92H,7-13,16-34,36-37,70H2,1-3H3,(H,75,79)(H,78,95)(H,80,93)(H,81,99)(H,82,102)(H,83,97)(H,84,101)(H,85,96)(H,86,100)(H,87,103)(H,88,98)(H,106,107)(H4,71,72,76)(H4,73,74,77)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-/m0/s1
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n/an/an/an/a 0.0620n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Agonist activity at rat APJ-R expressed in HEK293 cells assessed as inhibition of forskolin- stimulated cAMP accumulation incubated for 30 mins by HT...


J Med Chem 62: 10456-10465 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01513
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM50506019
PNG
(CHEMBL4473347)
Show SMILES CCC[C@@H](NC(=O)c1ccc(c(c1)C(O)=O)-c1c(Cl)cccc1-c1nc2cc(OC)ccc2[nH]1)c1ccccc1
Show InChI InChI=1S/C32H28ClN3O4/c1-3-8-26(19-9-5-4-6-10-19)36-31(37)20-13-15-22(24(17-20)32(38)39)29-23(11-7-12-25(29)33)30-34-27-16-14-21(40-2)18-28(27)35-30/h4-7,9-18,26H,3,8H2,1-2H3,(H,34,35)(H,36,37)(H,38,39)/t26-/m1/s1
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n/an/an/an/a 0.0620n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Agonist activity at human APJ-R expressed in HEK293 cells assessed as inhibition of forskolin- stimulated cAMP accumulation incubated for 30 mins by ...


J Med Chem 62: 10456-10465 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01513
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269647
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H28FN7O5S/c1-6-38-21-12-7-9-18(29-21)24-30-31-25(33(24)22-19(36-4)10-8-11-20(22)37-5)32-39(34,35)16(3)15(2)23-27-13-17(26)14-28-23/h7-16H,6H2,1-5H3,(H,31,32)/t15-,16-/m0/s1
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n/an/an/an/a 0.0620n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)


BindingDB Entry DOI: 10.7270/Q28P62TV
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269647
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H28FN7O5S/c1-6-38-21-12-7-9-18(29-21)24-30-31-25(33(24)22-19(36-4)10-8-11-20(22)37-5)32-39(34,35)16(3)15(2)23-27-13-17(26)14-28-23/h7-16H,6H2,1-5H3,(H,31,32)/t15-,16-/m0/s1
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n/an/an/an/a 0.0620n/an/a7.5n/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269647
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H28FN7O5S/c1-6-38-21-12-7-9-18(29-21)24-30-31-25(33(24)22-19(36-4)10-8-11-20(22)37-5)32-39(34,35)16(3)15(2)23-27-13-17(26)14-28-23/h7-16H,6H2,1-5H3,(H,31,32)/t15-,16-/m0/s1
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n/an/an/an/a 0.0620n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447997
PNG
(US10689367, Example 325.0 | US10689367, Example 32...)
Show SMILES CC[C@H]([C@@H]1CCCCO1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1
Show InChI InChI=1S/C24H32ClN7O5S/c1-5-18(19-10-6-7-12-37-19)32-23(17-9-8-11-20(28-17)35-3)29-30-24(32)31-38(33,34)15(2)21(36-4)22-26-13-16(25)14-27-22/h8-9,11,13-15,18-19,21H,5-7,10,12H2,1-4H3,(H,30,31)/t15-,18+,19-,21-/m0/s1
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n/an/an/an/a 0.0640n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269658
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H31N7O6S/c1-7-39-21-13-8-10-18(29-21)25-30-31-26(33(25)22-19(36-4)11-9-12-20(22)37-5)32-40(34,35)17(3)23(38-6)24-27-14-16(2)15-28-24/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/m0/s1
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n/an/an/an/a 0.0650n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)


BindingDB Entry DOI: 10.7270/Q28P62TV
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269658
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H31N7O6S/c1-7-39-21-13-8-10-18(29-21)25-30-31-26(33(25)22-19(36-4)11-9-12-20(22)37-5)32-40(34,35)17(3)23(38-6)24-27-14-16(2)15-28-24/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/m0/s1
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n/an/an/an/a 0.0650n/an/a7.5n/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269658
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H31N7O6S/c1-7-39-21-13-8-10-18(29-21)25-30-31-26(33(25)22-19(36-4)11-9-12-20(22)37-5)32-40(34,35)17(3)23(38-6)24-27-14-16(2)15-28-24/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269666
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H31N7O5S/c1-7-38-22-13-8-10-19(29-22)25-30-31-26(33(25)23-20(36-5)11-9-12-21(23)37-6)32-39(34,35)18(4)17(3)24-27-14-16(2)15-28-24/h8-15,17-18H,7H2,1-6H3,(H,31,32)/t17-,18-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269666
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H31N7O5S/c1-7-38-22-13-8-10-19(29-22)25-30-31-26(33(25)23-20(36-5)11-9-12-21(23)37-6)32-39(34,35)18(4)17(3)24-27-14-16(2)15-28-24/h8-15,17-18H,7H2,1-6H3,(H,31,32)/t17-,18-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269666
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H31N7O5S/c1-7-38-22-13-8-10-19(29-22)25-30-31-26(33(25)23-20(36-5)11-9-12-21(23)37-6)32-39(34,35)18(4)17(3)24-27-14-16(2)15-28-24/h8-15,17-18H,7H2,1-6H3,(H,31,32)/t17-,18-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)


BindingDB Entry DOI: 10.7270/Q28P62TV
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM50541322
PNG
(CHEMBL4639193)
Show SMILES CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)O1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O
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n/an/an/an/a 0.0700n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human APJ expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production


Bioorg Med Chem Lett 30: (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM50078002
PNG
(CHEMBL3417389)
Show SMILES CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@](C)(Cc1ccccc1)C(O)=O
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n/an/an/an/a 0.0700n/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated ...


J Med Chem 58: 2431-40 (2015)


Article DOI: 10.1021/jm501916k
BindingDB Entry DOI: 10.7270/Q21V5GNR
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM456785
PNG
(US10736883, Example 262.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1ccc(C)o1
Show InChI InChI=1S/C24H28N6O5S/c1-14-12-25-22(26-13-14)16(3)17(4)36(31,32)29-24-28-27-23(20-11-10-15(2)35-20)30(24)21-18(33-5)8-7-9-19(21)34-6/h7-13,16-17H,1-6H3,(H,28,29)/t16-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10736883 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM456615
PNG
(US10736883, Example 56.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)nnc1-c1ccc(C)o1
Show InChI InChI=1S/C23H25FN6O5S/c1-13-9-10-19(35-13)22-27-28-23(30(22)20-17(33-4)7-6-8-18(20)34-5)29-36(31,32)15(3)14(2)21-25-11-16(24)12-26-21/h6-12,14-15H,1-5H3,(H,28,29)/t14-,15-/m0/s1
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n/an/an/an/a 0.0710n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10736883 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM456688
PNG
(US10736883, Example 143.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(C)o2)n1-c1c(OC)cccc1OC)c1ccc(cc1C#N)C#N
Show InChI InChI=1S/C27H26N6O6S/c1-16-9-12-23(39-16)26-30-31-27(33(26)24-21(36-3)7-6-8-22(24)37-4)32-40(34,35)17(2)25(38-5)20-11-10-18(14-28)13-19(20)15-29/h6-13,17,25H,1-5H3,(H,31,32)/t17-,25-/m0/s1
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n/an/an/an/a 0.0720n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10736883 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM456689
PNG
(US10736883, Example 144.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)C[C@H](O)c2ccc(Cl)cc2S(C)(=O)=O)nnc1-c1ccc(C)o1
Show InChI InChI=1S/C24H25ClN4O8S2/c1-14-8-11-20(37-14)23-26-27-24(29(23)22-18(35-2)6-5-7-19(22)36-3)28-39(33,34)13-17(30)16-10-9-15(25)12-21(16)38(4,31)32/h5-12,17,30H,13H2,1-4H3,(H,27,28)/t17-/m0/s1
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n/an/an/an/a 0.0730n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10736883 (2020)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269952
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES CO[C@H](CS(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1S(C)(=O)=O)C#N
Show InChI InChI=1S/C27H28N6O8S2/c1-38-20-9-7-10-21(39-2)25(20)33-26(19-8-6-11-24(29-19)41-4)30-31-27(33)32-43(36,37)16-22(40-3)18-13-12-17(15-28)14-23(18)42(5,34)35/h6-14,22H,16H2,1-5H3,(H,31,32)/t22-/m1/s1
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n/an/an/an/a 0.0730n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)


BindingDB Entry DOI: 10.7270/Q28P62TV
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269952
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES CO[C@H](CS(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1S(C)(=O)=O)C#N
Show InChI InChI=1S/C27H28N6O8S2/c1-38-20-9-7-10-21(39-2)25(20)33-26(19-8-6-11-24(29-19)41-4)30-31-27(33)32-43(36,37)16-22(40-3)18-13-12-17(15-28)14-23(18)42(5,34)35/h6-14,22H,16H2,1-5H3,(H,31,32)/t22-/m1/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269952
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES CO[C@H](CS(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1S(C)(=O)=O)C#N
Show InChI InChI=1S/C27H28N6O8S2/c1-38-20-9-7-10-21(39-2)25(20)33-26(19-8-6-11-24(29-19)41-4)30-31-27(33)32-43(36,37)16-22(40-3)18-13-12-17(15-28)14-23(18)42(5,34)35/h6-14,22H,16H2,1-5H3,(H,31,32)/t22-/m1/s1
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n/an/an/an/a 0.0730n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM456742
PNG
(US10736883, Example 212.0 | US10736883, Example 21...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](O)c2ncc(Cl)cn2)nnc1-c1ccc(C)o1
Show InChI InChI=1S/C22H23ClN6O6S/c1-12-8-9-17(35-12)21-26-27-22(29(21)18-15(33-3)6-5-7-16(18)34-4)28-36(31,32)13(2)19(30)20-24-10-14(23)11-25-20/h5-11,13,19,30H,1-4H3,(H,27,28)/t13-,19-/m0/s1
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n/an/an/an/a 0.0740n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10736883 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269596
PNG
((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23+/m0/s1
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n/an/an/an/a 0.0780n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269596
PNG
((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23+/m0/s1
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n/an/an/an/a 0.0780n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)


BindingDB Entry DOI: 10.7270/Q28P62TV
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269596
PNG
((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23+/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM447707
PNG
(US10689367, Example 25.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1C(C1CC1)C1CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H28ClN7O4S/c1-13(20(35-3)21-25-11-16(24)12-26-21)36(32,33)30-23-29-28-22(17-5-4-6-18(27-17)34-2)31(23)19(14-7-8-14)15-9-10-15/h4-6,11-15,19-20H,7-10H2,1-3H3,(H,29,30)/t13-,20-/m0/s1
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n/an/an/an/a 0.0800n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10689367 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270042
PNG
((1S,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)
Show SMILES CCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H26ClN7O5S/c1-5-37-21(22-27-13-17(25)14-28-22)15(2)38(33,34)31-24-30-29-23(16-8-7-11-26-12-16)32(24)20-18(35-3)9-6-10-19(20)36-4/h6-15,21H,5H2,1-4H3,(H,30,31)/t15-,21+/m0/s1
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n/an/an/an/a 0.0820n/an/a7.5n/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270042
PNG
((1S,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)
Show SMILES CCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H26ClN7O5S/c1-5-37-21(22-27-13-17(25)14-28-22)15(2)38(33,34)31-24-30-29-23(16-8-7-11-26-12-16)32(24)20-18(35-3)9-6-10-19(20)36-4/h6-15,21H,5H2,1-4H3,(H,30,31)/t15-,21+/m0/s1
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n/an/an/an/a 0.0820n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)


BindingDB Entry DOI: 10.7270/Q28P62TV
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270042
PNG
((1S,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)
Show SMILES CCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H26ClN7O5S/c1-5-37-21(22-27-13-17(25)14-28-22)15(2)38(33,34)31-24-30-29-23(16-8-7-11-26-12-16)32(24)20-18(35-3)9-6-10-19(20)36-4/h6-15,21H,5H2,1-4H3,(H,30,31)/t15-,21+/m0/s1
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n/an/an/an/a 0.0820n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM50506037
PNG
(CHEMBL4518406)
Show SMILES CCC[C@@H](NC(=O)c1ccc(c(c1)C(O)=O)-c1cc(Cl)ccc1-c1nc2cc(OC)ccc2[nH]1)c1ccccc1
Show InChI InChI=1S/C32H28ClN3O4/c1-3-7-27(19-8-5-4-6-9-19)36-31(37)20-10-13-23(26(16-20)32(38)39)25-17-21(33)11-14-24(25)30-34-28-15-12-22(40-2)18-29(28)35-30/h4-6,8-18,27H,3,7H2,1-2H3,(H,34,35)(H,36,37)(H,38,39)/t27-/m1/s1
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n/an/an/an/a 0.0830n/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Agonist activity at human APJ-R expressed in HEK293 cells assessed as inhibition of forskolin- stimulated cAMP accumulation incubated for 30 mins by ...


J Med Chem 62: 10456-10465 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01513
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM456671
PNG
(US10736883, Example 118.0)
Show SMILES CCO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2ccc(C)o2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H30N6O6S/c1-7-36-22(23-26-13-15(2)14-27-23)17(4)38(32,33)30-25-29-28-24(20-12-11-16(3)37-20)31(25)21-18(34-5)9-8-10-19(21)35-6/h8-14,17,22H,7H2,1-6H3,(H,29,30)/t17-,22-/m1/s1
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n/an/an/an/a 0.0840n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10736883 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM456786
PNG
(US10736883, Example 263.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(C)o2)n1-c1c(OC)cccc1OC)c1cn2ccccc2n1
Show InChI InChI=1S/C26H28N6O6S/c1-16-12-13-21(38-16)25-28-29-26(32(25)23-19(35-3)9-8-10-20(23)36-4)30-39(33,34)17(2)24(37-5)18-15-31-14-7-6-11-22(31)27-18/h6-15,17,24H,1-5H3,(H,29,30)/t17-,24-/m0/s1
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n/an/an/an/a 0.0860n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10736883 (2020)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269592
PNG
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CCO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/m1/s1
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n/an/an/an/a 0.0900n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)


BindingDB Entry DOI: 10.7270/Q28P62TV
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269592
PNG
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CCO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/m1/s1
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n/an/an/an/a 0.0900n/an/a7.5n/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM456690
PNG
(US10736883, Example 145.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)C[C@H](O)c2ccc(Cl)cc2S(C)(=O)=O)nnc1-c1ccc(C)o1
Show InChI InChI=1S/C24H25ClN4O8S2/c1-14-8-11-20(37-14)23-26-27-24(29(23)22-18(35-2)6-5-7-19(22)36-3)28-39(33,34)13-17(30)16-10-9-15(25)12-21(16)38(4,31)32/h5-12,17,30H,13H2,1-4H3,(H,27,28)/t17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10736883 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM359804
PNG
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CCO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270114
PNG
((2R,3S)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C24H26ClN7O4S/c1-14-9-17(11-26-10-14)23-29-30-24(32(23)21-19(35-4)7-6-8-20(21)36-5)31-37(33,34)16(3)15(2)22-27-12-18(25)13-28-22/h6-13,15-16H,1-5H3,(H,30,31)/t15-,16-/m0/s1
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n/an/an/an/a 0.0910n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)


BindingDB Entry DOI: 10.7270/Q28P62TV
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM456572
PNG
(US10736883, Example 9.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(Cl)cc2NC(C)=O)nnc1-c1ccco1
Show InChI InChI=1S/C24H25ClN6O6S/c1-14(11-17-18(27-15(2)32)12-16(25)13-26-17)38(33,34)30-24-29-28-23(21-9-6-10-37-21)31(24)22-19(35-3)7-5-8-20(22)36-4/h5-10,12-14H,11H2,1-4H3,(H,27,32)(H,29,30)/t14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US10736883 (2020)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270120
PNG
((2R,3S)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C24H26ClN7O4S/c1-14-9-17(11-26-10-14)23-29-30-24(32(23)21-19(35-4)7-6-8-20(21)36-5)31-37(33,34)16(3)15(2)22-27-12-18(25)13-28-22/h6-13,15-16H,1-5H3,(H,30,31)/t15-,16-/m0/s1
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n/an/an/an/a 0.0910n/an/a7.5n/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270114
PNG
((2R,3S)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C24H26ClN7O4S/c1-14-9-17(11-26-10-14)23-29-30-24(32(23)21-19(35-4)7-6-8-20(21)36-5)31-37(33,34)16(3)15(2)22-27-12-18(25)13-28-22/h6-13,15-16H,1-5H3,(H,30,31)/t15-,16-/m0/s1
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JXS
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269725
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(F)cn1
Show InChI InChI=1S/C24H26FN7O6S/c1-14(21(38-5)22-26-12-15(25)13-27-22)39(33,34)31-24-30-29-23(16-8-6-11-19(28-16)37-4)32(24)20-17(35-2)9-7-10-18(20)36-3/h6-14,21H,1-5H3,(H,30,31)/t14-,21-/m0/s1
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n/an/an/an/a 0.0920n/an/a7.5n/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
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