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Compile Data Set for Download or QSAR

Found 3895 hits Enz. Inhib. hit(s) with Target = 'Apelin receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270203
PNG
((1R,2S,P)—N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1
Show InChI InChI=1/C24H28N8O6S/c1-14-12-26-21(27-13-14)20(37-5)15(2)39(33,34)31-24-30-29-22(16-8-7-9-18(28-16)36-4)32(24)19-17(35-3)10-11-25-23(19)38-6/h7-13,15,20H,1-6H3,(H,30,31)/t15-,20-/s2
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n/an/an/an/a 0.0320n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270203
PNG
((1R,2S,P)—N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1
Show InChI InChI=1/C24H28N8O6S/c1-14-12-26-21(27-13-14)20(37-5)15(2)39(33,34)31-24-30-29-22(16-8-7-9-18(28-16)36-4)32(24)19-17(35-3)10-11-25-23(19)38-6/h7-13,15,20H,1-6H3,(H,30,31)/t15-,20-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


Article DOI: 10.1021/jm960158n
BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270203
PNG
((1R,2S,P)—N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1
Show InChI InChI=1/C24H28N8O6S/c1-14-12-26-21(27-13-14)20(37-5)15(2)39(33,34)31-24-30-29-22(16-8-7-9-18(28-16)36-4)32(24)19-17(35-3)10-11-25-23(19)38-6/h7-13,15,20H,1-6H3,(H,30,31)/t15-,20-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM50078006
PNG
(CHEMBL3417385)
Show SMILES CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)C(=O)c1ccccc1)C(O)=O
Show InChI InChI=1/C77H114N22O17/c1-4-5-18-52(73(113)99-36-15-24-60(99)72(112)95-56(75(115)116)38-45-25-27-47(28-26-45)63(103)46-16-7-6-8-17-46)92-70(110)58-22-13-34-97(58)62(102)41-86-64(104)49(19-9-10-31-78)89-68(108)55(39-48-40-83-43-87-48)94-69(109)57(42-100)96-67(107)54(37-44(2)3)93-65(105)50(20-11-32-84-76(79)80)90-71(111)59-23-14-35-98(59)74(114)53(21-12-33-85-77(81)82)91-66(106)51-29-30-61(101)88-51/h6-8,16-17,25-28,40,43-44,49-60,100H,4-5,9-15,18-24,29-39,41-42,78H2,1-3H3,(H,83,87)(H,86,104)(H,88,101)(H,89,108)(H,90,111)(H,91,106)(H,92,110)(H,93,105)(H,94,109)(H,95,112)(H,96,107)(H,115,116)(H4,79,80,84)(H4,81,82,85)/t49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-/s2
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Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated ...


J Med Chem 58: 2431-40 (2015)


Article DOI: 10.1021/jm501916k
BindingDB Entry DOI: 10.7270/Q21V5GNR
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269647
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C25H28FN7O5S/c1-6-38-21-12-7-9-18(29-21)24-30-31-25(33(24)22-19(36-4)10-8-11-20(22)37-5)32-39(34,35)16(3)15(2)23-27-13-17(26)14-28-23/h7-16H,6H2,1-5H3,(H,31,32)/t15-,16-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269647
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C25H28FN7O5S/c1-6-38-21-12-7-9-18(29-21)24-30-31-25(33(24)22-19(36-4)10-8-11-20(22)37-5)32-39(34,35)16(3)15(2)23-27-13-17(26)14-28-23/h7-16H,6H2,1-5H3,(H,31,32)/t15-,16-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269647
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C25H28FN7O5S/c1-6-38-21-12-7-9-18(29-21)24-30-31-25(33(24)22-19(36-4)10-8-11-20(22)37-5)32-39(34,35)16(3)15(2)23-27-13-17(26)14-28-23/h7-16H,6H2,1-5H3,(H,31,32)/t15-,16-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


Article DOI: 10.1021/jm960158n
BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269658
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C26H31N7O6S/c1-7-39-21-13-8-10-18(29-21)25-30-31-26(33(25)22-19(36-4)11-9-12-20(22)37-5)32-40(34,35)17(3)23(38-6)24-27-14-16(2)15-28-24/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269658
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C26H31N7O6S/c1-7-39-21-13-8-10-18(29-21)25-30-31-26(33(25)22-19(36-4)11-9-12-20(22)37-5)32-40(34,35)17(3)23(38-6)24-27-14-16(2)15-28-24/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269658
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C26H31N7O6S/c1-7-39-21-13-8-10-18(29-21)25-30-31-26(33(25)22-19(36-4)11-9-12-20(22)37-5)32-40(34,35)17(3)23(38-6)24-27-14-16(2)15-28-24/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


Article DOI: 10.1021/jm960158n
BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269666
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C26H31N7O5S/c1-7-38-22-13-8-10-19(29-22)25-30-31-26(33(25)23-20(36-5)11-9-12-21(23)37-6)32-39(34,35)18(4)17(3)24-27-14-16(2)15-28-24/h8-15,17-18H,7H2,1-6H3,(H,31,32)/t17-,18-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269666
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C26H31N7O5S/c1-7-38-22-13-8-10-19(29-22)25-30-31-26(33(25)23-20(36-5)11-9-12-21(23)37-6)32-39(34,35)18(4)17(3)24-27-14-16(2)15-28-24/h8-15,17-18H,7H2,1-6H3,(H,31,32)/t17-,18-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269666
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C26H31N7O5S/c1-7-38-22-13-8-10-19(29-22)25-30-31-26(33(25)23-20(36-5)11-9-12-21(23)37-6)32-39(34,35)18(4)17(3)24-27-14-16(2)15-28-24/h8-15,17-18H,7H2,1-6H3,(H,31,32)/t17-,18-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


Article DOI: 10.1021/jm960158n
BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM50078002
PNG
(CHEMBL3417389)
Show SMILES CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@](C)(Cc1ccccc1)C(O)=O
Show InChI InChI=1/C71H112N22O16/c1-5-6-19-47(66(106)93-33-16-25-54(93)65(105)90-71(4,68(108)109)36-42-17-8-7-9-18-42)86-63(103)52-23-14-31-91(52)56(96)38-80-57(97)44(20-10-11-28-72)83-61(101)50(35-43-37-77-40-81-43)88-62(102)51(39-94)89-60(100)49(34-41(2)3)87-58(98)45(21-12-29-78-69(73)74)84-64(104)53-24-15-32-92(53)67(107)48(22-13-30-79-70(75)76)85-59(99)46-26-27-55(95)82-46/h7-9,17-18,37,40-41,44-54,94H,5-6,10-16,19-36,38-39,72H2,1-4H3,(H,77,81)(H,80,97)(H,82,95)(H,83,101)(H,84,104)(H,85,99)(H,86,103)(H,87,98)(H,88,102)(H,89,100)(H,90,105)(H,108,109)(H4,73,74,78)(H4,75,76,79)/t44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,71-/s2
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Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated ...


J Med Chem 58: 2431-40 (2015)


Article DOI: 10.1021/jm501916k
BindingDB Entry DOI: 10.7270/Q21V5GNR
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269952
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES CO[C@H](CS(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1S(C)(=O)=O)C#N
Show InChI InChI=1/C27H28N6O8S2/c1-38-20-9-7-10-21(39-2)25(20)33-26(19-8-6-11-24(29-19)41-4)30-31-27(33)32-43(36,37)16-22(40-3)18-13-12-17(15-28)14-23(18)42(5,34)35/h6-14,22H,16H2,1-5H3,(H,31,32)/t22-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269952
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES CO[C@H](CS(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1S(C)(=O)=O)C#N
Show InChI InChI=1/C27H28N6O8S2/c1-38-20-9-7-10-21(39-2)25(20)33-26(19-8-6-11-24(29-19)41-4)30-31-27(33)32-43(36,37)16-22(40-3)18-13-12-17(15-28)14-23(18)42(5,34)35/h6-14,22H,16H2,1-5H3,(H,31,32)/t22-/s2
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US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269952
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES CO[C@H](CS(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1S(C)(=O)=O)C#N
Show InChI InChI=1/C27H28N6O8S2/c1-38-20-9-7-10-21(39-2)25(20)33-26(19-8-6-11-24(29-19)41-4)30-31-27(33)32-43(36,37)16-22(40-3)18-13-12-17(15-28)14-23(18)42(5,34)35/h6-14,22H,16H2,1-5H3,(H,31,32)/t22-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


Article DOI: 10.1021/jm960158n
BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269596
PNG
((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23+/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269596
PNG
((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23+/s2
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US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


Article DOI: 10.1021/jm960158n
BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269596
PNG
((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23+/s2
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Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270042
PNG
((1S,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)
Show SMILES CCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1/C24H26ClN7O5S/c1-5-37-21(22-27-13-17(25)14-28-22)15(2)38(33,34)31-24-30-29-23(16-8-7-11-26-12-16)32(24)20-18(35-3)9-6-10-19(20)36-4/h6-15,21H,5H2,1-4H3,(H,30,31)/t15-,21+/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270042
PNG
((1S,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)
Show SMILES CCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1/C24H26ClN7O5S/c1-5-37-21(22-27-13-17(25)14-28-22)15(2)38(33,34)31-24-30-29-23(16-8-7-11-26-12-16)32(24)20-18(35-3)9-6-10-19(20)36-4/h6-15,21H,5H2,1-4H3,(H,30,31)/t15-,21+/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


Article DOI: 10.1021/jm960158n
BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270042
PNG
((1S,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)
Show SMILES CCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1/C24H26ClN7O5S/c1-5-37-21(22-27-13-17(25)14-28-22)15(2)38(33,34)31-24-30-29-23(16-8-7-11-26-12-16)32(24)20-18(35-3)9-6-10-19(20)36-4/h6-15,21H,5H2,1-4H3,(H,30,31)/t15-,21+/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269592
PNG
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CCO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269592
PNG
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CCO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


Article DOI: 10.1021/jm960158n
BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM359804
PNG
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CCO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270114
PNG
((2R,3S)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1/C24H26ClN7O4S/c1-14-9-17(11-26-10-14)23-29-30-24(32(23)21-19(35-4)7-6-8-20(21)36-5)31-37(33,34)16(3)15(2)22-27-12-18(25)13-28-22/h6-13,15-16H,1-5H3,(H,30,31)/t15-,16-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270114
PNG
((2R,3S)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1/C24H26ClN7O4S/c1-14-9-17(11-26-10-14)23-29-30-24(32(23)21-19(35-4)7-6-8-20(21)36-5)31-37(33,34)16(3)15(2)22-27-12-18(25)13-28-22/h6-13,15-16H,1-5H3,(H,30,31)/t15-,16-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270120
PNG
((2R,3S)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1/C24H26ClN7O4S/c1-14-9-17(11-26-10-14)23-29-30-24(32(23)21-19(35-4)7-6-8-20(21)36-5)31-37(33,34)16(3)15(2)22-27-12-18(25)13-28-22/h6-13,15-16H,1-5H3,(H,30,31)/t15-,16-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


Article DOI: 10.1021/jm960158n
BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269725
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(F)cn1
Show InChI InChI=1/C24H26FN7O6S/c1-14(21(38-5)22-26-12-15(25)13-27-22)39(33,34)31-24-30-29-23(16-8-6-11-19(28-16)37-4)32(24)20-17(35-2)9-7-10-18(20)36-3/h6-14,21H,1-5H3,(H,30,31)/t14-,21-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


Article DOI: 10.1021/jm960158n
BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269725
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(F)cn1
Show InChI InChI=1/C24H26FN7O6S/c1-14(21(38-5)22-26-12-15(25)13-27-22)39(33,34)31-24-30-29-23(16-8-6-11-19(28-16)37-4)32(24)20-17(35-2)9-7-10-18(20)36-3/h6-14,21H,1-5H3,(H,30,31)/t14-,21-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269725
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(F)cn1
Show InChI InChI=1/C24H26FN7O6S/c1-14(21(38-5)22-26-12-15(25)13-27-22)39(33,34)31-24-30-29-23(16-8-6-11-19(28-16)37-4)32(24)20-17(35-2)9-7-10-18(20)36-3/h6-14,21H,1-5H3,(H,30,31)/t14-,21-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270036
PNG
((1S,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)
Show SMILES CO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1/C24H26ClN7O6S/c1-14(21(38-5)22-26-12-15(25)13-27-22)39(33,34)31-24-30-29-23(16-8-6-11-19(28-16)37-4)32(24)20-17(35-2)9-7-10-18(20)36-3/h6-14,21H,1-5H3,(H,30,31)/t14-,21+/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270036
PNG
((1S,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)
Show SMILES CO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1/C24H26ClN7O6S/c1-14(21(38-5)22-26-12-15(25)13-27-22)39(33,34)31-24-30-29-23(16-8-6-11-19(28-16)37-4)32(24)20-17(35-2)9-7-10-18(20)36-3/h6-14,21H,1-5H3,(H,30,31)/t14-,21+/s2
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Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


Article DOI: 10.1021/jm960158n
BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270036
PNG
((1S,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)
Show SMILES CO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1/C24H26ClN7O6S/c1-14(21(38-5)22-26-12-15(25)13-27-22)39(33,34)31-24-30-29-23(16-8-6-11-19(28-16)37-4)32(24)20-17(35-2)9-7-10-18(20)36-3/h6-14,21H,1-5H3,(H,30,31)/t14-,21+/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270191
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COC1CN(C1)[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1/C28H34N8O6S/c1-17-13-29-26(30-14-17)24(35-15-19(16-35)39-3)18(2)43(37,38)34-28-33-32-27(20-9-7-12-23(31-20)42-6)36(28)25-21(40-4)10-8-11-22(25)41-5/h7-14,18-19,24H,15-16H2,1-6H3,(H,33,34)/t18-,24-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


Article DOI: 10.1021/jm960158n
BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM360422
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COC1CN(C1)[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1/C28H34N8O6S/c1-17-13-29-26(30-14-17)24(35-15-19(16-35)39-3)18(2)43(37,38)34-28-33-32-27(20-9-7-12-23(31-20)42-6)36(28)25-21(40-4)10-8-11-22(25)41-5/h7-14,18-19,24H,15-16H2,1-6H3,(H,33,34)/t18-,24-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269613
PNG
((2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C24H26FN7O5S/c1-14(22-26-12-16(25)13-27-22)15(2)38(33,34)31-24-30-29-23(17-8-6-11-20(28-17)37-5)32(24)21-18(35-3)9-7-10-19(21)36-4/h6-15H,1-5H3,(H,30,31)/t14-,15-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


Article DOI: 10.1021/jm960158n
BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269613
PNG
((2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C24H26FN7O5S/c1-14(22-26-12-16(25)13-27-22)15(2)38(33,34)31-24-30-29-23(17-8-6-11-20(28-17)37-5)32(24)21-18(35-3)9-7-10-19(21)36-4/h6-15H,1-5H3,(H,30,31)/t14-,15-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM360421
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COC1CN(C1)[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1/C28H34N8O6S/c1-17-13-29-26(30-14-17)24(35-15-19(16-35)39-3)18(2)43(37,38)34-28-33-32-27(20-9-7-12-23(31-20)42-6)36(28)25-21(40-4)10-8-11-22(25)41-5/h7-14,18-19,24H,15-16H2,1-6H3,(H,33,34)/t18-,24-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269613
PNG
((2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C24H26FN7O5S/c1-14(22-26-12-16(25)13-27-22)15(2)38(33,34)31-24-30-29-23(17-8-6-11-20(28-17)37-5)32(24)21-18(35-3)9-7-10-19(21)36-4/h6-15H,1-5H3,(H,30,31)/t14-,15-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269952
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES CO[C@H](CS(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1S(C)(=O)=O)C#N
Show InChI InChI=1/C27H28N6O8S2/c1-38-20-9-7-10-21(39-2)25(20)33-26(19-8-6-11-24(29-19)41-4)30-31-27(33)32-43(36,37)16-22(40-3)18-13-12-17(15-28)14-23(18)42(5,34)35/h6-14,22H,16H2,1-5H3,(H,31,32)/t22-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


Article DOI: 10.1021/jm960158n
BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM269952
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES CO[C@H](CS(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1S(C)(=O)=O)C#N
Show InChI InChI=1/C27H28N6O8S2/c1-38-20-9-7-10-21(39-2)25(20)33-26(19-8-6-11-24(29-19)41-4)30-31-27(33)32-43(36,37)16-22(40-3)18-13-12-17(15-28)14-23(18)42(5,34)35/h6-14,22H,16H2,1-5H3,(H,31,32)/t22-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM269952
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES CO[C@H](CS(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1S(C)(=O)=O)C#N
Show InChI InChI=1/C27H28N6O8S2/c1-38-20-9-7-10-21(39-2)25(20)33-26(19-8-6-11-24(29-19)41-4)30-31-27(33)32-43(36,37)16-22(40-3)18-13-12-17(15-28)14-23(18)42(5,34)35/h6-14,22H,16H2,1-5H3,(H,31,32)/t22-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270129
PNG
((2S,3R)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C24H26ClN7O5S/c1-14(22-26-12-16(25)13-27-22)15(2)38(33,34)31-24-30-29-23(17-8-6-11-20(28-17)37-5)32(24)21-18(35-3)9-7-10-19(21)36-4/h6-15H,1-5H3,(H,30,31)/t14-,15-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM270170
PNG
((1S,2S)-1-isopropoxy-1-(5-methylpyrimidin-2-yl)pro...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1-c1cccc(C)n1
Show InChI InChI=1/C27H33N7O5S/c1-16(2)39-24(25-28-14-17(3)15-29-25)19(5)40(35,36)33-27-32-31-26(20-11-8-10-18(4)30-20)34(27)23-21(37-6)12-9-13-22(23)38-7/h8-16,19,24H,1-7H3,(H,32,33)/t19-,24+/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270170
PNG
((1S,2S)-1-isopropoxy-1-(5-methylpyrimidin-2-yl)pro...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1-c1cccc(C)n1
Show InChI InChI=1/C27H33N7O5S/c1-16(2)39-24(25-28-14-17(3)15-29-25)19(5)40(35,36)33-27-32-31-26(20-11-8-10-18(4)30-20)34(27)23-21(37-6)12-9-13-22(23)38-7/h8-16,19,24H,1-7H3,(H,32,33)/t19-,24+/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


Article DOI: 10.1021/jm960158n
BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270170
PNG
((1S,2S)-1-isopropoxy-1-(5-methylpyrimidin-2-yl)pro...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1-c1cccc(C)n1
Show InChI InChI=1/C27H33N7O5S/c1-16(2)39-24(25-28-14-17(3)15-29-25)19(5)40(35,36)33-27-32-31-26(20-11-8-10-18(4)30-20)34(27)23-21(37-6)12-9-13-22(23)38-7/h8-16,19,24H,1-7H3,(H,32,33)/t19-,24+/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270129
PNG
((2S,3R)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C24H26ClN7O5S/c1-14(22-26-12-16(25)13-27-22)15(2)38(33,34)31-24-30-29-23(17-8-6-11-20(28-17)37-5)32(24)21-18(35-3)9-7-10-19(21)36-4/h6-15H,1-5H3,(H,30,31)/t14-,15-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)


Article DOI: 10.1021/jm960158n
BindingDB Entry DOI: 10.7270/Q26T0PP0
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM270129
PNG
((2S,3R)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1/C24H26ClN7O5S/c1-14(22-26-12-16(25)13-27-22)15(2)38(33,34)31-24-30-29-23(17-8-6-11-20(28-17)37-5)32(24)21-18(35-3)9-7-10-19(21)36-4/h6-15H,1-5H3,(H,30,31)/t14-,15-/s2
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Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10221162 (2019)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
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