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Compile Data Set for Download or QSAR

Found 227 hits Enz. Inhib. hit(s) with Target = 'Atrial natriuretic peptide receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50262475
PNG
(CHEMBL4090153)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO
Show InChI InChI=1S/C127H203N45O39S3/c1-9-64(6)99-121(209)150-52-94(182)151-65(7)100(188)155-76(34-35-91(129)179)109(197)167-85(56-174)104(192)149-53-96(184)153-78(43-62(2)3)102(190)148-54-97(185)154-89(119(207)164-82(48-92(130)180)114(202)169-86(57-175)116(204)163-81(46-67-23-14-11-15-24-67)113(201)158-73(27-18-39-143-125(135)136)107(195)166-84(122(210)211)47-68-30-32-69(178)33-31-68)60-213-214-61-90(171-118(206)88(59-177)170-117(205)87(58-176)168-108(196)74(28-19-40-144-126(137)138)156-106(194)72(26-17-38-142-124(133)134)157-112(200)79(44-63(4)5)161-101(189)70(128)55-173)120(208)162-80(45-66-21-12-10-13-22-66)103(191)147-50-93(181)146-51-95(183)152-71(25-16-37-141-123(131)132)105(193)160-77(36-42-212-8)110(198)165-83(49-98(186)187)115(203)159-75(111(199)172-99)29-20-41-145-127(139)140/h10-15,21-24,30-33,62-65,70-90,99,173-178H,9,16-20,25-29,34-61,128H2,1-8H3,(H2,129,179)(H2,130,180)(H,146,181)(H,147,191)(H,148,190)(H,149,192)(H,150,209)(H,151,182)(H,152,183)(H,153,184)(H,154,185)(H,155,188)(H,156,194)(H,157,200)(H,158,201)(H,159,203)(H,160,193)(H,161,189)(H,162,208)(H,163,204)(H,164,207)(H,165,198)(H,166,195)(H,167,197)(H,168,196)(H,169,202)(H,170,205)(H,171,206)(H,172,199)(H,186,187)(H,210,211)(H4,131,132,141)(H4,133,134,142)(H4,135,136,143)(H4,137,138,144)(H4,139,140,145)/t64-,65-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89+,90-,99-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.100n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-...


Bioorg Med Chem Lett 27: 4904-4907 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50452476
PNG
(CHEMBL4206902)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO
Show InChI InChI=1S/C127H203N45O39S3/c1-9-64(6)99-121(209)150-52-94(182)151-65(7)100(188)155-76(34-35-91(129)179)109(197)167-85(56-174)104(192)149-53-96(184)153-78(43-62(2)3)102(190)148-54-97(185)154-89(119(207)164-82(48-92(130)180)114(202)169-86(57-175)116(204)163-81(46-67-23-14-11-15-24-67)113(201)158-73(27-18-39-143-125(135)136)107(195)166-84(122(210)211)47-68-30-32-69(178)33-31-68)60-213-214-61-90(171-118(206)88(59-177)170-117(205)87(58-176)168-108(196)74(28-19-40-144-126(137)138)156-106(194)72(26-17-38-142-124(133)134)157-112(200)79(44-63(4)5)161-101(189)70(128)55-173)120(208)162-80(45-66-21-12-10-13-22-66)103(191)147-50-93(181)146-51-95(183)152-71(25-16-37-141-123(131)132)105(193)160-77(36-42-212-8)110(198)165-83(49-98(186)187)115(203)159-75(111(199)172-99)29-20-41-145-127(139)140/h10-15,21-24,30-33,62-65,70-90,99,173-178H,9,16-20,25-29,34-61,128H2,1-8H3,(H2,129,179)(H2,130,180)(H,146,181)(H,147,191)(H,148,190)(H,149,192)(H,150,209)(H,151,182)(H,152,183)(H,153,184)(H,154,185)(H,155,188)(H,156,194)(H,157,200)(H,158,201)(H,159,203)(H,160,193)(H,161,189)(H,162,208)(H,163,204)(H,164,207)(H,165,198)(H,166,195)(H,167,197)(H,168,196)(H,169,202)(H,170,205)(H,171,206)(H,172,199)(H,186,187)(H,210,211)(H4,131,132,141)(H4,133,134,142)(H4,135,136,143)(H4,137,138,144)(H4,139,140,145)/t64-,65-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85+,86-,87-,88-,89-,90-,99-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.100n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50230986
PNG
(CARPERITIDE | Carperitide | SUN-4936)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO
Show InChI InChI=1S/C127H203N45O39S3/c1-9-64(6)99-121(209)150-52-94(182)151-65(7)100(188)155-76(34-35-91(129)179)109(197)167-85(56-174)104(192)149-53-96(184)153-78(43-62(2)3)102(190)148-54-97(185)154-89(119(207)164-82(48-92(130)180)114(202)169-86(57-175)116(204)163-81(46-67-23-14-11-15-24-67)113(201)158-73(27-18-39-143-125(135)136)107(195)166-84(122(210)211)47-68-30-32-69(178)33-31-68)60-213-214-61-90(171-118(206)88(59-177)170-117(205)87(58-176)168-108(196)74(28-19-40-144-126(137)138)156-106(194)72(26-17-38-142-124(133)134)157-112(200)79(44-63(4)5)161-101(189)70(128)55-173)120(208)162-80(45-66-21-12-10-13-22-66)103(191)147-50-93(181)146-51-95(183)152-71(25-16-37-141-123(131)132)105(193)160-77(36-42-212-8)110(198)165-83(49-98(186)187)115(203)159-75(111(199)172-99)29-20-41-145-127(139)140/h10-15,21-24,30-33,62-65,70-90,99,173-178H,9,16-20,25-29,34-61,128H2,1-8H3,(H2,129,179)(H2,130,180)(H,146,181)(H,147,191)(H,148,190)(H,149,192)(H,150,209)(H,151,182)(H,152,183)(H,153,184)(H,154,185)(H,155,188)(H,156,194)(H,157,200)(H,158,201)(H,159,203)(H,160,193)(H,161,189)(H,162,208)(H,163,204)(H,164,207)(H,165,198)(H,166,195)(H,167,197)(H,168,196)(H,169,202)(H,170,205)(H,171,206)(H,172,199)(H,186,187)(H,210,211)(H4,131,132,141)(H4,133,134,142)(H4,135,136,143)(H4,137,138,144)(H4,139,140,145)/t64-,65-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,99-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.100n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 1762-1769 (2017)


Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50112321
PNG
(Atrial natriuretic peptide analogue | CHEMBL407206...)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@@H](CO)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@@H](N)CCSC
Show InChI InChI=1S/C75H117N27O19S4/c1-5-39(2)59-72(121)99-53(35-103)69(118)101-55(71(120)96-50(29-41-17-19-43(104)20-18-41)66(115)92-45(60(77)109)14-9-23-85-73(78)79)37-125-124-36-54(100-61(110)44(76)21-26-122-3)70(119)97-51(30-42-32-84-38-90-42)67(116)95-49(28-40-12-7-6-8-13-40)62(111)89-33-56(105)88-34-57(106)91-46(15-10-24-86-74(80)81)63(112)94-48(22-27-123-4)64(113)98-52(31-58(107)108)68(117)93-47(65(114)102-59)16-11-25-87-75(82)83/h6-8,12-13,17-20,32,38-39,44-55,59,103-104H,5,9-11,14-16,21-31,33-37,76H2,1-4H3,(H2,77,109)(H,84,90)(H,88,105)(H,89,111)(H,91,106)(H,92,115)(H,93,117)(H,94,112)(H,95,116)(H,96,120)(H,97,119)(H,98,113)(H,99,121)(H,100,110)(H,101,118)(H,102,114)(H,107,108)(H4,78,79,85)(H4,80,81,86)(H4,82,83,87)/t39-,44-,45-,46-,47+,48+,49+,50-,51-,52-,53+,54-,55+,59-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.680n/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compound


Bioorg Med Chem Lett 12: 1245-7 (2002)


Article DOI: 10.1016/s0960-894x(02)00148-8
BindingDB Entry DOI: 10.7270/Q22R3QZ6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452453
PNG
(CHEMBL4202512)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)[C@@H](C)CC
Show InChI InChI=1S/C128H205N45O39S2/c1-10-64(7)99-121(209)151-52-94(183)152-66(9)101(189)156-77(36-37-91(130)180)109(197)167-85(56-175)105(193)150-53-96(185)154-78(43-62(3)4)103(191)149-54-97(186)155-89(119(207)164-82(48-92(131)181)114(202)169-86(57-176)116(204)163-81(46-68-25-16-13-17-26-68)113(201)159-74(29-20-40-144-126(136)137)107(195)166-84(123(211)212)47-69-32-34-70(179)35-33-69)60-213-214-61-90(171-118(206)88(59-178)170-117(205)87(58-177)168-108(196)75(30-21-41-145-127(138)139)157-106(194)73(28-19-39-143-125(134)135)158-112(200)79(44-63(5)6)161-102(190)71(129)55-174)120(208)162-80(45-67-23-14-12-15-24-67)104(192)148-50-93(182)147-51-95(184)153-72(27-18-38-142-124(132)133)110(198)173-100(65(8)11-2)122(210)165-83(49-98(187)188)115(203)160-76(111(199)172-99)31-22-42-146-128(140)141/h12-17,23-26,32-35,62-66,71-90,99-100,174-179H,10-11,18-22,27-31,36-61,129H2,1-9H3,(H2,130,180)(H2,131,181)(H,147,182)(H,148,192)(H,149,191)(H,150,193)(H,151,209)(H,152,183)(H,153,184)(H,154,185)(H,155,186)(H,156,189)(H,157,194)(H,158,200)(H,159,201)(H,160,203)(H,161,190)(H,162,208)(H,163,204)(H,164,207)(H,165,210)(H,166,195)(H,167,197)(H,168,196)(H,169,202)(H,170,205)(H,171,206)(H,172,199)(H,173,198)(H,187,188)(H,211,212)(H4,132,133,142)(H4,134,135,143)(H4,136,137,144)(H4,138,139,145)(H4,140,141,146)/t64-,65-,66-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85+,86-,87-,88-,89-,90-,99-,100-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50230986
PNG
(CARPERITIDE | Carperitide | SUN-4936)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO
Show InChI InChI=1S/C127H203N45O39S3/c1-9-64(6)99-121(209)150-52-94(182)151-65(7)100(188)155-76(34-35-91(129)179)109(197)167-85(56-174)104(192)149-53-96(184)153-78(43-62(2)3)102(190)148-54-97(185)154-89(119(207)164-82(48-92(130)180)114(202)169-86(57-175)116(204)163-81(46-67-23-14-11-15-24-67)113(201)158-73(27-18-39-143-125(135)136)107(195)166-84(122(210)211)47-68-30-32-69(178)33-31-68)60-213-214-61-90(171-118(206)88(59-177)170-117(205)87(58-176)168-108(196)74(28-19-40-144-126(137)138)156-106(194)72(26-17-38-142-124(133)134)157-112(200)79(44-63(4)5)161-101(189)70(128)55-173)120(208)162-80(45-66-21-12-10-13-22-66)103(191)147-50-93(181)146-51-95(183)152-71(25-16-37-141-123(131)132)105(193)160-77(36-42-212-8)110(198)165-83(49-98(186)187)115(203)159-75(111(199)172-99)29-20-41-145-127(139)140/h10-15,21-24,30-33,62-65,70-90,99,173-178H,9,16-20,25-29,34-61,128H2,1-8H3,(H2,129,179)(H2,130,180)(H,146,181)(H,147,191)(H,148,190)(H,149,192)(H,150,209)(H,151,182)(H,152,183)(H,153,184)(H,154,185)(H,155,188)(H,156,194)(H,157,200)(H,158,201)(H,159,203)(H,160,193)(H,161,189)(H,162,208)(H,163,204)(H,164,207)(H,165,198)(H,166,195)(H,167,197)(H,168,196)(H,169,202)(H,170,205)(H,171,206)(H,172,199)(H,186,187)(H,210,211)(H4,131,132,141)(H4,133,134,142)(H4,135,136,143)(H4,137,138,144)(H4,139,140,145)/t64-,65-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,99-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 1762-1769 (2017)


Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50230984
PNG
(CHEMBL4099832)
Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CCCCC1N(C(N)=NC1=O)c1nc(NC(N)=N)nc(Nc2ccc(Nc3nc(NC(N)=N)nc(n3)N3C(CCCC)C(=O)N=C3N)cc2)n1
Show InChI InChI=1S/C28H38N20O2.2C2HF3O2/c1-3-5-7-15-17(49)37-21(33)47(15)27-43-23(41-25(45-27)39-19(29)30)35-13-9-11-14(12-10-13)36-24-42-26(40-20(31)32)46-28(44-24)48-16(8-6-4-2)18(50)38-22(48)34;2*3-2(4,5)1(6)7/h9-12,15-16H,3-8H2,1-2H3,(H2,33,37,49)(H2,34,38,50)(H5,29,30,35,39,41,43,45)(H5,31,32,36,40,42,44,46);2*(H,6,7)
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n/an/an/an/a 2n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 1762-1769 (2017)


Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50112320
PNG
(Atrial natriuretic peptide analogue | CHEMBL405572...)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCSC)NC(=O)[C@@H]2CCCN2C(=O)CNC(=O)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@@H](CO)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@@H](N)CCSC
Show InChI InChI=1S/C74H112N24O19S4/c1-5-39(2)59-72(117)94-52(35-99)68(113)96-54(70(115)91-49(29-41-17-19-43(100)20-18-41)65(110)87-45(60(76)105)14-9-23-82-73(77)78)37-121-120-36-53(95-61(106)44(75)21-26-118-3)69(114)92-50(30-42-32-81-38-86-42)66(111)90-48(28-40-12-7-6-8-13-40)62(107)85-33-56(101)84-34-57(102)98-25-11-16-55(98)71(116)89-47(22-27-119-4)63(108)93-51(31-58(103)104)67(112)88-46(64(109)97-59)15-10-24-83-74(79)80/h6-8,12-13,17-20,32,38-39,44-55,59,99-100H,5,9-11,14-16,21-31,33-37,75H2,1-4H3,(H2,76,105)(H,81,86)(H,84,101)(H,85,107)(H,87,110)(H,88,112)(H,89,116)(H,90,111)(H,91,115)(H,92,114)(H,93,108)(H,94,117)(H,95,106)(H,96,113)(H,97,109)(H,103,104)(H4,77,78,82)(H4,79,80,83)/t39-,44-,45-,46+,47+,48+,49-,50-,51-,52+,53-,54+,55-,59-/m0/s1
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n/an/an/an/a 4.90n/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compound


Bioorg Med Chem Lett 12: 1245-7 (2002)


Article DOI: 10.1016/s0960-894x(02)00148-8
BindingDB Entry DOI: 10.7270/Q22R3QZ6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50230983
PNG
(CHEMBL4061575)
Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(C)CC1N(C(N)=NC1=O)c1nc(NC(N)=N)nc(Nc2ccc(Nc3nc(NC(N)=N)nc(n3)N3C(CC(C)C)C(=O)N=C3N)cc2)n1
Show InChI InChI=1S/C28H38N20O2.2C2HF3O2/c1-11(2)9-15-17(49)37-21(33)47(15)27-43-23(41-25(45-27)39-19(29)30)35-13-5-7-14(8-6-13)36-24-42-26(40-20(31)32)46-28(44-24)48-16(10-12(3)4)18(50)38-22(48)34;2*3-2(4,5)1(6)7/h5-8,11-12,15-16H,9-10H2,1-4H3,(H2,33,37,49)(H2,34,38,50)(H5,29,30,35,39,41,43,45)(H5,31,32,36,40,42,44,46);2*(H,6,7)
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n/an/an/an/a 5.80n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 1762-1769 (2017)


Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50230988
PNG
(CHEMBL4089697)
Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(C)CC1N(C(N)=NC1=O)c1nc(NC2CCC(CC2)Nc2nc(NC(N)=N)nc(n2)N2C(CC(C)C)C(=O)N=C2N)nc(NC(N)=N)n1
Show InChI InChI=1S/C28H44N20O2.4C2HF3O2/c1-11(2)9-15-17(49)37-21(33)47(15)27-43-23(41-25(45-27)39-19(29)30)35-13-5-7-14(8-6-13)36-24-42-26(40-20(31)32)46-28(44-24)48-16(10-12(3)4)18(50)38-22(48)34;4*3-2(4,5)1(6)7/h11-16H,5-10H2,1-4H3,(H2,33,37,49)(H2,34,38,50)(H5,29,30,35,39,41,43,45)(H5,31,32,36,40,42,44,46);4*(H,6,7)
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n/an/an/an/a 8.10n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 1762-1769 (2017)


Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50112316
PNG
(Atrial natriuretic peptide analogue | CHEMBL384862)
Show SMILES CC[C@H](C)[C@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCNC(N)=N)C(N)=O)NC(=O)[C@@H](N)CCSC
Show InChI InChI=1S/C74H116N26O18S4/c1-5-39(2)58-71(118)97-53(35-101)68(115)99-55(70(117)94-50(31-41-17-19-43(102)20-18-41)65(112)90-45(59(76)106)21-27-87-74(81)82)37-122-121-36-54(98-60(107)44(75)22-28-119-3)69(116)95-51(32-42-34-83-38-88-42)66(113)93-49(30-40-12-7-6-8-13-40)61(108)84-24-11-16-56(103)89-46(14-9-25-85-72(77)78)62(109)92-48(23-29-120-4)63(110)96-52(33-57(104)105)67(114)91-47(64(111)100-58)15-10-26-86-73(79)80/h6-8,12-13,17-20,34,38-39,44-55,58,101-102H,5,9-11,14-16,21-33,35-37,75H2,1-4H3,(H2,76,106)(H,83,88)(H,84,108)(H,89,103)(H,90,112)(H,91,114)(H,92,109)(H,93,113)(H,94,117)(H,95,116)(H,96,110)(H,97,118)(H,98,107)(H,99,115)(H,100,111)(H,104,105)(H4,77,78,85)(H4,79,80,86)(H4,81,82,87)/t39-,44-,45-,46+,47-,48-,49+,50-,51-,52+,53-,54-,55-,58+/m0/s1
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n/an/an/an/a 8.30n/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compound


Bioorg Med Chem Lett 12: 1245-7 (2002)


Article DOI: 10.1016/s0960-894x(02)00148-8
BindingDB Entry DOI: 10.7270/Q22R3QZ6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 3


(Mus musculus)
BDBM287915
PNG
(CNP-22 | CNP-53 | Natriuretic peptide, C-type | US...)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CN
Show InChI InChI=1S/C93H157N27O28S3/c1-12-52(10)76-91(146)104-42-72(127)108-65(44-122)88(143)114-57(26-30-149-11)82(137)118-64(43-121)80(135)103-39-70(125)106-58(31-48(2)3)78(133)101-41-74(129)110-68(92(147)148)47-151-150-46-67(109-73(128)40-100-77(132)54(23-16-18-27-94)111-89(144)66(45-123)119-85(140)59(32-49(4)5)105-69(124)37-96)90(145)116-62(35-53-21-14-13-15-22-53)79(134)102-38-71(126)107-60(33-50(6)7)84(139)112-55(24-17-19-28-95)81(136)115-61(34-51(8)9)86(141)117-63(36-75(130)131)87(142)113-56(83(138)120-76)25-20-29-99-93(97)98/h13-15,21-22,48-52,54-68,76,121-123H,12,16-20,23-47,94-96H2,1-11H3,(H,100,132)(H,101,133)(H,102,134)(H,103,135)(H,104,146)(H,105,124)(H,106,125)(H,107,126)(H,108,127)(H,109,128)(H,110,129)(H,111,144)(H,112,139)(H,113,142)(H,114,143)(H,115,136)(H,116,145)(H,117,141)(H,118,137)(H,119,140)(H,120,138)(H,130,131)(H,147,148)(H4,97,98,99)/t52-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,76-/m0/s1
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US Patent
n/an/an/an/a 13.8n/an/an/an/a



UCL Business PLC

US Patent


Assay Description
Male rats (Sprague-Dawley; 200-250 g) were stunned and killed by cervical dislocation. The mesentery was removed and third-order arteries mounted in ...


US Patent US10087144 (2018)


BindingDB Entry DOI: 10.7270/Q2CN75XD
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50230982
PNG
(CHEMBL4097422)
Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(C)CC1N(C(N)=NC1=O)c1nc(NC(N)=N)nc(Nc2ccc(Nc3nc(NC(N)=N)nc(n3)N3C(C)C(=O)N=C3N)cc2)n1
Show InChI InChI=1S/C25H32N20O2.2C2HF3O2/c1-9(2)8-13-15(47)35-19(31)45(13)25-41-21(39-23(43-25)37-17(28)29)33-12-6-4-11(5-7-12)32-20-38-22(36-16(26)27)42-24(40-20)44-10(3)14(46)34-18(44)30;2*3-2(4,5)1(6)7/h4-7,9-10,13H,8H2,1-3H3,(H2,30,34,46)(H2,31,35,47)(H5,26,27,32,36,38,40,42)(H5,28,29,33,37,39,41,43);2*(H,6,7)
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n/an/an/an/a 19n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 1762-1769 (2017)


Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50230984
PNG
(CHEMBL4099832)
Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CCCCC1N(C(N)=NC1=O)c1nc(NC(N)=N)nc(Nc2ccc(Nc3nc(NC(N)=N)nc(n3)N3C(CCCC)C(=O)N=C3N)cc2)n1
Show InChI InChI=1S/C28H38N20O2.2C2HF3O2/c1-3-5-7-15-17(49)37-21(33)47(15)27-43-23(41-25(45-27)39-19(29)30)35-13-9-11-14(12-10-13)36-24-42-26(40-20(31)32)46-28(44-24)48-16(8-6-4-2)18(50)38-22(48)34;2*3-2(4,5)1(6)7/h9-12,15-16H,3-8H2,1-2H3,(H2,33,37,49)(H2,34,38,50)(H5,29,30,35,39,41,43,45)(H5,31,32,36,40,42,44,46);2*(H,6,7)
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n/an/an/an/a 23n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 1762-1769 (2017)


Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50112317
PNG
(Atrial natriuretic peptide analogue | CHEMBL439465...)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@@H](CO)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@@H](N)CCSC
Show InChI InChI=1S/C72H110N24O19S4/c1-6-37(2)57-70(115)93-51(33-97)67(112)95-53(69(114)90-48(27-40-16-18-42(98)19-17-40)64(109)86-44(58(74)103)14-10-22-80-71(75)76)35-119-118-34-52(94-60(105)43(73)20-24-116-4)68(113)91-49(28-41-30-79-36-84-41)65(110)89-47(26-39-12-8-7-9-13-39)61(106)83-31-54(99)82-32-55(100)85-38(3)59(104)87-46(21-25-117-5)62(107)92-50(29-56(101)102)66(111)88-45(63(108)96-57)15-11-23-81-72(77)78/h7-9,12-13,16-19,30,36-38,43-53,57,97-98H,6,10-11,14-15,20-29,31-35,73H2,1-5H3,(H2,74,103)(H,79,84)(H,82,99)(H,83,106)(H,85,100)(H,86,109)(H,87,104)(H,88,111)(H,89,110)(H,90,114)(H,91,113)(H,92,107)(H,93,115)(H,94,105)(H,95,112)(H,96,108)(H,101,102)(H4,75,76,80)(H4,77,78,81)/t37-,38-,43-,44-,45+,46+,47+,48-,49-,50-,51+,52-,53+,57-/m0/s1
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n/an/an/an/a 30n/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compound


Bioorg Med Chem Lett 12: 1245-7 (2002)


Article DOI: 10.1016/s0960-894x(02)00148-8
BindingDB Entry DOI: 10.7270/Q22R3QZ6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50452475
PNG
(CHEMBL4218179)
Show SMILES CC(C)[C@@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C29H39FN6O3/c1-17(2)26(16-38)35-29(39)33-23-10-8-22(9-11-23)32-27-24-14-20(19-5-4-6-21(30)13-19)7-12-25(24)34-28(36-27)31-18(3)15-37/h4-7,12-14,17-18,22-23,26,37-38H,8-11,15-16H2,1-3H3,(H2,33,35,39)(H2,31,32,34,36)/t18-,22-,23+,26-/m1/s1
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n/an/an/an/a 41n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452455
PNG
(CHEMBL4215510)
Show SMILES CC(C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)N[C@@H](CO)C(C)C)c2cc(cnc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C28H38FN7O2/c1-16(2)24(15-37)34-28(38)33-22-10-8-21(9-11-22)32-26-23-13-19(18-6-5-7-20(29)12-18)14-30-25(23)35-27(36-26)31-17(3)4/h5-7,12-14,16-17,21-22,24,37H,8-11,15H2,1-4H3,(H2,33,34,38)(H2,30,31,32,35,36)/t21-,22+,24-/m0/s1
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n/an/an/an/a 43n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50112318
PNG
(Atrial natriuretic peptide analogue | CHEMBL409400)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]2CCCN2C(=O)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@@H](CO)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@@H](N)CCSC
Show InChI InChI=1S/C78H121N27O19S4/c1-5-41(2)61-75(124)101-55(37-106)71(120)103-57(73(122)98-52(32-43-19-21-45(107)22-20-43)68(117)93-47(62(80)111)15-9-25-88-76(81)82)39-128-127-38-56(102-63(112)46(79)23-29-125-3)72(121)99-53(33-44-35-87-40-92-44)69(118)97-51(31-42-13-7-6-8-14-42)64(113)91-36-59(108)105-28-12-18-58(105)74(123)96-48(16-10-26-89-77(83)84)65(114)95-50(24-30-126-4)66(115)100-54(34-60(109)110)70(119)94-49(67(116)104-61)17-11-27-90-78(85)86/h6-8,13-14,19-22,35,40-41,46-58,61,106-107H,5,9-12,15-18,23-34,36-39,79H2,1-4H3,(H2,80,111)(H,87,92)(H,91,113)(H,93,117)(H,94,119)(H,95,114)(H,96,123)(H,97,118)(H,98,122)(H,99,121)(H,100,115)(H,101,124)(H,102,112)(H,103,120)(H,104,116)(H,109,110)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t41-,46-,47-,48-,49+,50+,51+,52-,53-,54-,55+,56-,57+,58+,61-/m0/s1
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n/an/an/an/a 47n/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compound


Bioorg Med Chem Lett 12: 1245-7 (2002)


Article DOI: 10.1016/s0960-894x(02)00148-8
BindingDB Entry DOI: 10.7270/Q22R3QZ6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452456
PNG
(CHEMBL4206652)
Show SMILES CC(C)[C@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ncc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C28H38FN7O3/c1-16(2)24(15-38)34-28(39)33-22-9-7-21(8-10-22)32-26-23-12-19(18-5-4-6-20(29)11-18)13-30-25(23)35-27(36-26)31-17(3)14-37/h4-6,11-13,16-17,21-22,24,37-38H,7-10,14-15H2,1-3H3,(H2,33,34,39)(H2,30,31,32,35,36)/t17-,21-,22+,24+/m1/s1
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n/an/an/an/a 62n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452457
PNG
(CHEMBL4213559)
Show SMILES CC(C)[C@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C29H39FN6O3/c1-17(2)26(16-38)35-29(39)33-23-10-8-22(9-11-23)32-27-24-14-20(19-5-4-6-21(30)13-19)7-12-25(24)34-28(36-27)31-18(3)15-37/h4-7,12-14,17-18,22-23,26,37-38H,8-11,15-16H2,1-3H3,(H2,33,35,39)(H2,31,32,34,36)/t18-,22-,23+,26+/m1/s1
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n/an/an/an/a 65n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50112323
PNG
(Atrial natriuretic peptide analogue | CHEMBL414517)
Show SMILES CC[C@H](C)[C@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@@H](N)CCSC
Show InChI InChI=1S/C75H115N27O19S3/c1-4-39(2)59-71(120)98-52(35-103)67(116)100-54(69(118)95-49(29-41-18-20-43(104)21-19-41)64(113)92-45(60(77)109)14-8-23-85-73(78)79)37-124-123-36-53(99-61(110)44(76)22-27-122-3)68(117)96-50(30-42-32-84-38-90-42)65(114)94-48(28-40-12-6-5-7-13-40)62(111)89-33-56(105)88-34-57(106)91-47(16-10-25-87-75(82)83)72(121)102-26-11-17-55(102)70(119)97-51(31-58(107)108)66(115)93-46(63(112)101-59)15-9-24-86-74(80)81/h5-7,12-13,18-21,32,38-39,44-55,59,103-104H,4,8-11,14-17,22-31,33-37,76H2,1-3H3,(H2,77,109)(H,84,90)(H,88,105)(H,89,111)(H,91,106)(H,92,113)(H,93,115)(H,94,114)(H,95,118)(H,96,117)(H,97,119)(H,98,120)(H,99,110)(H,100,116)(H,101,112)(H,107,108)(H4,78,79,85)(H4,80,81,86)(H4,82,83,87)/t39-,44-,45-,46-,47+,48+,49-,50-,51+,52-,53-,54-,55-,59+/m0/s1
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n/an/an/an/a 66n/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compound


Bioorg Med Chem Lett 12: 1245-7 (2002)


Article DOI: 10.1016/s0960-894x(02)00148-8
BindingDB Entry DOI: 10.7270/Q22R3QZ6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452451
PNG
(CHEMBL4210772)
Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)(C)CO)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C28H37FN6O3/c1-17(15-36)30-26-33-24-12-7-19(18-5-4-6-20(29)13-18)14-23(24)25(34-26)31-21-8-10-22(11-9-21)32-27(38)35-28(2,3)16-37/h4-7,12-14,17,21-22,36-37H,8-11,15-16H2,1-3H3,(H2,32,35,38)(H2,30,31,33,34)/t17-,21-,22+/m1/s1
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n/an/an/an/a 66n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50452457
PNG
(CHEMBL4213559)
Show SMILES CC(C)[C@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C29H39FN6O3/c1-17(2)26(16-38)35-29(39)33-23-10-8-22(9-11-23)32-27-24-14-20(19-5-4-6-21(30)13-19)7-12-25(24)34-28(36-27)31-18(3)15-37/h4-7,12-14,17-18,22-23,26,37-38H,8-11,15-16H2,1-3H3,(H2,33,35,39)(H2,31,32,34,36)/t18-,22-,23+,26+/m1/s1
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n/an/an/an/a 71n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50262473
PNG
(CHEMBL4071795)
Show SMILES CC(C)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)C2CCCN(C)C2)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C30H39FN6O/c1-19(2)32-30-35-27-14-9-21(20-6-4-8-23(31)16-20)17-26(27)28(36-30)33-24-10-12-25(13-11-24)34-29(38)22-7-5-15-37(3)18-22/h4,6,8-9,14,16-17,19,22,24-25H,5,7,10-13,15,18H2,1-3H3,(H,34,38)(H2,32,33,35,36)/t22?,24-,25-
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n/an/an/an/a 73n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-...


Bioorg Med Chem Lett 27: 4904-4907 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452464
PNG
(CHEMBL4212125)
Show SMILES CC(C)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C27H35FN6O2/c1-16(2)29-27(36)32-22-10-8-21(9-11-22)31-25-23-14-19(18-5-4-6-20(28)13-18)7-12-24(23)33-26(34-25)30-17(3)15-35/h4-7,12-14,16-17,21-22,35H,8-11,15H2,1-3H3,(H2,29,32,36)(H2,30,31,33,34)/t17-,21-,22+/m1/s1
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n/an/an/an/a 74n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50230988
PNG
(CHEMBL4089697)
Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(C)CC1N(C(N)=NC1=O)c1nc(NC2CCC(CC2)Nc2nc(NC(N)=N)nc(n2)N2C(CC(C)C)C(=O)N=C2N)nc(NC(N)=N)n1
Show InChI InChI=1S/C28H44N20O2.4C2HF3O2/c1-11(2)9-15-17(49)37-21(33)47(15)27-43-23(41-25(45-27)39-19(29)30)35-13-5-7-14(8-6-13)36-24-42-26(40-20(31)32)46-28(44-24)48-16(10-12(3)4)18(50)38-22(48)34;4*3-2(4,5)1(6)7/h11-16H,5-10H2,1-4H3,(H2,33,37,49)(H2,34,38,50)(H5,29,30,35,39,41,43,45)(H5,31,32,36,40,42,44,46);4*(H,6,7)
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n/an/an/an/a 76n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 1762-1769 (2017)


Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50452458
PNG
(CHEMBL4207138)
Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2(CO)CCCC2)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C30H39FN6O3/c1-19(17-38)32-28-35-26-12-7-21(20-5-4-6-22(31)15-20)16-25(26)27(36-28)33-23-8-10-24(11-9-23)34-29(40)37-30(18-39)13-2-3-14-30/h4-7,12,15-16,19,23-24,38-39H,2-3,8-11,13-14,17-18H2,1H3,(H2,34,37,40)(H2,32,33,35,36)/t19-,23-,24+/m1/s1
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n/an/an/an/a 78n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50452455
PNG
(CHEMBL4215510)
Show SMILES CC(C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)N[C@@H](CO)C(C)C)c2cc(cnc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C28H38FN7O2/c1-16(2)24(15-37)34-28(38)33-22-10-8-21(9-11-22)32-26-23-13-19(18-6-5-7-20(29)12-18)14-30-25(23)35-27(36-26)31-17(3)4/h5-7,12-14,16-17,21-22,24,37H,8-11,15H2,1-4H3,(H2,33,34,38)(H2,30,31,32,35,36)/t21-,22+,24-/m0/s1
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n/an/an/an/a 98n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50112326
PNG
(Atrial natriuretic peptide analogue | CHEMBL413653)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@@H](CO)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@@H](N)CCSC
Show InChI InChI=1S/C78H121N27O19S4/c1-5-41(2)61-74(123)101-55(37-106)70(119)103-57(72(121)97-51(31-43-19-21-45(107)22-20-43)67(116)94-47(62(80)111)15-9-25-88-76(81)82)39-128-127-38-56(102-63(112)46(79)23-29-125-3)71(120)98-52(33-44-35-87-40-92-44)68(117)100-54(32-42-13-7-6-8-14-42)75(124)105-28-12-18-58(105)73(122)91-36-59(108)93-48(16-10-26-89-77(83)84)64(113)96-50(24-30-126-4)65(114)99-53(34-60(109)110)69(118)95-49(66(115)104-61)17-11-27-90-78(85)86/h6-8,13-14,19-22,35,40-41,46-58,61,106-107H,5,9-12,15-18,23-34,36-39,79H2,1-4H3,(H2,80,111)(H,87,92)(H,91,122)(H,93,108)(H,94,116)(H,95,118)(H,96,113)(H,97,121)(H,98,120)(H,99,114)(H,100,117)(H,101,123)(H,102,112)(H,103,119)(H,104,115)(H,109,110)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t41-,46-,47-,48-,49+,50+,51-,52-,53-,54+,55+,56-,57+,58-,61-/m0/s1
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n/an/an/an/a 108n/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compound


Bioorg Med Chem Lett 12: 1245-7 (2002)


Article DOI: 10.1016/s0960-894x(02)00148-8
BindingDB Entry DOI: 10.7270/Q22R3QZ6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50452456
PNG
(CHEMBL4206652)
Show SMILES CC(C)[C@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ncc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C28H38FN7O3/c1-16(2)24(15-38)34-28(39)33-22-9-7-21(8-10-22)32-26-23-12-19(18-5-4-6-20(29)11-18)13-30-25(23)35-27(36-26)31-17(3)14-37/h4-6,11-13,16-17,21-22,24,37-38H,7-10,14-15H2,1-3H3,(H2,33,34,39)(H2,30,31,32,35,36)/t17-,21-,22+,24+/m1/s1
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n/an/an/an/a 110n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452458
PNG
(CHEMBL4207138)
Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2(CO)CCCC2)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C30H39FN6O3/c1-19(17-38)32-28-35-26-12-7-21(20-5-4-6-22(31)15-20)16-25(26)27(36-28)33-23-8-10-24(11-9-23)34-29(40)37-30(18-39)13-2-3-14-30/h4-7,12,15-16,19,23-24,38-39H,2-3,8-11,13-14,17-18H2,1H3,(H2,34,37,40)(H2,32,33,35,36)/t19-,23-,24+/m1/s1
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n/an/an/an/a 120n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452454
PNG
(CHEMBL4216406)
Show SMILES CC(C)[C@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2cnc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C28H38FN7O3/c1-16(2)25(15-38)35-28(39)33-21-9-7-20(8-10-21)32-26-22-12-23(18-5-4-6-19(29)11-18)30-13-24(22)34-27(36-26)31-17(3)14-37/h4-6,11-13,16-17,20-21,25,37-38H,7-10,14-15H2,1-3H3,(H2,33,35,39)(H2,31,32,34,36)/t17-,20-,21+,25+/m1/s1
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n/an/an/an/a 130n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452473
PNG
(CHEMBL4205804)
Show SMILES COC[C@@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)C)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C28H37FN6O2/c1-17(2)30-28(36)33-23-11-9-22(10-12-23)32-26-24-15-20(19-6-5-7-21(29)14-19)8-13-25(24)34-27(35-26)31-18(3)16-37-4/h5-8,13-15,17-18,22-23H,9-12,16H2,1-4H3,(H2,30,33,36)(H2,31,32,34,35)/t18-,22-,23+/m1/s1
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n/an/an/an/a 160n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50262458
PNG
(CHEMBL4073156)
Show SMILES CC(C)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)C2CCCN(C)C2)c2cc(ccc2n1)-c1ccccc1
Show InChI InChI=1S/C30H40N6O/c1-20(2)31-30-34-27-16-11-22(21-8-5-4-6-9-21)18-26(27)28(35-30)32-24-12-14-25(15-13-24)33-29(37)23-10-7-17-36(3)19-23/h4-6,8-9,11,16,18,20,23-25H,7,10,12-15,17,19H2,1-3H3,(H,33,37)(H2,31,32,34,35)/t23?,24-,25-
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n/an/an/an/a 170n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-...


Bioorg Med Chem Lett 27: 4904-4907 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50112322
PNG
(Atrial natriuretic peptide analogue | CHEMBL385216)
Show SMILES CC[C@H](C)[C@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@@H](N)CCSC
Show InChI InChI=1S/C74H116N26O18S4/c1-5-39(2)58-71(118)97-53(35-101)68(115)99-55(70(117)94-50(31-41-17-19-43(102)20-18-41)65(112)90-45(59(76)106)14-9-24-85-72(77)78)37-122-121-36-54(98-60(107)44(75)22-28-119-3)69(116)95-51(32-42-34-83-38-88-42)66(113)93-49(30-40-12-7-6-8-13-40)61(108)84-27-21-56(103)89-46(15-10-25-86-73(79)80)62(109)92-48(23-29-120-4)63(110)96-52(33-57(104)105)67(114)91-47(64(111)100-58)16-11-26-87-74(81)82/h6-8,12-13,17-20,34,38-39,44-55,58,101-102H,5,9-11,14-16,21-33,35-37,75H2,1-4H3,(H2,76,106)(H,83,88)(H,84,108)(H,89,103)(H,90,112)(H,91,114)(H,92,109)(H,93,113)(H,94,117)(H,95,116)(H,96,110)(H,97,118)(H,98,107)(H,99,115)(H,100,111)(H,104,105)(H4,77,78,85)(H4,79,80,86)(H4,81,82,87)/t39-,44-,45-,46+,47-,48-,49+,50-,51-,52+,53-,54-,55-,58+/m0/s1
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n/an/an/an/a 177n/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compound


Bioorg Med Chem Lett 12: 1245-7 (2002)


Article DOI: 10.1016/s0960-894x(02)00148-8
BindingDB Entry DOI: 10.7270/Q22R3QZ6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452470
PNG
(CHEMBL4207573)
Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CC2)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C27H33FN6O2/c1-16(15-35)29-26-33-24-12-5-18(17-3-2-4-19(28)13-17)14-23(24)25(34-26)30-20-6-8-21(9-7-20)31-27(36)32-22-10-11-22/h2-5,12-14,16,20-22,35H,6-11,15H2,1H3,(H2,31,32,36)(H2,29,30,33,34)/t16-,20-,21+/m1/s1
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Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50112324
PNG
(Atrial natriuretic peptide analogue | CHEMBL408343)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@@H](CO)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@@H](N)CCSC
Show InChI InChI=1S/C73H113N27O19S3/c1-5-37(2)57-70(119)97-51(33-101)67(116)99-53(69(118)95-48(27-40-17-19-42(102)20-18-40)64(113)91-44(58(75)107)14-9-22-83-71(76)77)35-122-121-34-52(98-60(109)43(74)21-25-120-4)68(117)96-49(28-41-30-82-36-88-41)65(114)94-47(26-39-12-7-6-8-13-39)61(110)87-31-54(103)86-32-55(104)90-45(15-10-23-84-72(78)79)62(111)89-38(3)59(108)93-50(29-56(105)106)66(115)92-46(63(112)100-57)16-11-24-85-73(80)81/h6-8,12-13,17-20,30,36-38,43-53,57,101-102H,5,9-11,14-16,21-29,31-35,74H2,1-4H3,(H2,75,107)(H,82,88)(H,86,103)(H,87,110)(H,89,111)(H,90,104)(H,91,113)(H,92,115)(H,93,108)(H,94,114)(H,95,118)(H,96,117)(H,97,119)(H,98,109)(H,99,116)(H,100,112)(H,105,106)(H4,76,77,83)(H4,78,79,84)(H4,80,81,85)/t37-,38+,43-,44-,45-,46+,47+,48-,49-,50-,51+,52-,53+,57-/m0/s1
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n/an/an/an/a 198n/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compound


Bioorg Med Chem Lett 12: 1245-7 (2002)


Article DOI: 10.1016/s0960-894x(02)00148-8
BindingDB Entry DOI: 10.7270/Q22R3QZ6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50452473
PNG
(CHEMBL4205804)
Show SMILES COC[C@@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)C)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C28H37FN6O2/c1-17(2)30-28(36)33-23-11-9-22(10-12-23)32-26-24-15-20(19-6-5-7-21(29)14-19)8-13-25(24)34-27(35-26)31-18(3)16-37-4/h5-8,13-15,17-18,22-23H,9-12,16H2,1-4H3,(H2,30,33,36)(H2,31,32,34,35)/t18-,22-,23+/m1/s1
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Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50112325
PNG
(Atrial natriuretic peptide analogue | CHEMBL402664)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@@H](CO)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@@H](N)CCSC
Show InChI InChI=1S/C73H114N26O18S4/c1-5-38(2)57-70(117)96-52(34-100)67(114)98-54(69(116)93-49(29-40-17-19-42(101)20-18-40)64(111)89-44(58(75)105)14-9-23-83-71(76)77)36-121-120-35-53(97-59(106)43(74)21-26-118-3)68(115)94-50(30-41-32-82-37-87-41)65(112)92-48(28-39-12-7-6-8-13-39)60(107)86-33-55(102)88-45(15-10-24-84-72(78)79)61(108)91-47(22-27-119-4)62(109)95-51(31-56(103)104)66(113)90-46(63(110)99-57)16-11-25-85-73(80)81/h6-8,12-13,17-20,32,37-38,43-54,57,100-101H,5,9-11,14-16,21-31,33-36,74H2,1-4H3,(H2,75,105)(H,82,87)(H,86,107)(H,88,102)(H,89,111)(H,90,113)(H,91,108)(H,92,112)(H,93,116)(H,94,115)(H,95,109)(H,96,117)(H,97,106)(H,98,114)(H,99,110)(H,103,104)(H4,76,77,83)(H4,78,79,84)(H4,80,81,85)/t38-,43-,44-,45-,46+,47+,48-,49-,50+,51-,52+,53-,54+,57-/m0/s1
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n/an/an/an/a 215n/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compound


Bioorg Med Chem Lett 12: 1245-7 (2002)


Article DOI: 10.1016/s0960-894x(02)00148-8
BindingDB Entry DOI: 10.7270/Q22R3QZ6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50452451
PNG
(CHEMBL4210772)
Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)(C)CO)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C28H37FN6O3/c1-17(15-36)30-26-33-24-12-7-19(18-5-4-6-20(29)13-18)14-23(24)25(34-26)31-21-8-10-22(11-9-21)32-27(38)35-28(2,3)16-37/h4-7,12-14,17,21-22,36-37H,8-11,15-16H2,1-3H3,(H2,32,35,38)(H2,30,31,33,34)/t17-,21-,22+/m1/s1
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Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50262472
PNG
(CHEMBL4077093)
Show SMILES CC(C)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)C2CCCN(C)C2)c2cc(ccc2n1)-c1ccccc1F
Show InChI InChI=1S/C30H39FN6O/c1-19(2)32-30-35-27-15-10-20(24-8-4-5-9-26(24)31)17-25(27)28(36-30)33-22-11-13-23(14-12-22)34-29(38)21-7-6-16-37(3)18-21/h4-5,8-10,15,17,19,21-23H,6-7,11-14,16,18H2,1-3H3,(H,34,38)(H2,32,33,35,36)/t21?,22-,23-
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n/an/an/an/a 220n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-...


Bioorg Med Chem Lett 27: 4904-4907 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50262474
PNG
(CHEMBL4082303)
Show SMILES CC(C)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)C2CCCN(C)C2)c2cc(ccc2n1)-c1cccc(Cl)c1
Show InChI InChI=1S/C30H39ClN6O/c1-19(2)32-30-35-27-14-9-21(20-6-4-8-23(31)16-20)17-26(27)28(36-30)33-24-10-12-25(13-11-24)34-29(38)22-7-5-15-37(3)18-22/h4,6,8-9,14,16-17,19,22,24-25H,5,7,10-13,15,18H2,1-3H3,(H,34,38)(H2,32,33,35,36)/t22?,24-,25-
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n/an/an/an/a 260n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-...


Bioorg Med Chem Lett 27: 4904-4907 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452469
PNG
(CHEMBL4210169)
Show SMILES COC[C@@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CC2)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C28H35FN6O2/c1-17(16-37-2)30-27-34-25-13-6-19(18-4-3-5-20(29)14-18)15-24(25)26(35-27)31-21-7-9-22(10-8-21)32-28(36)33-23-11-12-23/h3-6,13-15,17,21-23H,7-12,16H2,1-2H3,(H2,32,33,36)(H2,30,31,34,35)/t17-,21-,22+/m1/s1
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Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452468
PNG
(CHEMBL4205090)
Show SMILES CC(C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)N[C@@H](CO)C(C)C)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C29H39FN6O2/c1-17(2)26(16-37)35-29(38)33-23-11-9-22(10-12-23)32-27-24-15-20(19-6-5-7-21(30)14-19)8-13-25(24)34-28(36-27)31-18(3)4/h5-8,13-15,17-18,22-23,26,37H,9-12,16H2,1-4H3,(H2,33,35,38)(H2,31,32,34,36)/t22-,23+,26-/m0/s1
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Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50262485
PNG
(CHEMBL4098800)
Show SMILES CC(C)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)C2CCCN(C)C2)c2cc(ccc2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H39FN6O/c1-19(2)32-30-35-27-15-8-21(20-6-9-23(31)10-7-20)17-26(27)28(36-30)33-24-11-13-25(14-12-24)34-29(38)22-5-4-16-37(3)18-22/h6-10,15,17,19,22,24-25H,4-5,11-14,16,18H2,1-3H3,(H,34,38)(H2,32,33,35,36)/t22?,24-,25-
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n/an/an/an/a 310n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-...


Bioorg Med Chem Lett 27: 4904-4907 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50452464
PNG
(CHEMBL4212125)
Show SMILES CC(C)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C27H35FN6O2/c1-16(2)29-27(36)32-22-10-8-21(9-11-22)31-25-23-14-19(18-5-4-6-20(28)13-18)7-12-24(23)33-26(34-25)30-17(3)15-35/h4-7,12-14,16-17,21-22,35H,8-11,15H2,1-3H3,(H2,29,32,36)(H2,30,31,33,34)/t17-,21-,22+/m1/s1
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n/an/an/an/a 320n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50452467
PNG
(CHEMBL4218032)
Show SMILES CC(C)N[C@H]1C[C@@H](C1)C(=O)N[C@H]1CC[C@@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C31H42N6O2/c1-19(2)32-26-15-23(16-26)30(39)35-25-12-10-24(11-13-25)34-29-27-17-22(21-7-5-4-6-8-21)9-14-28(27)36-31(37-29)33-20(3)18-38/h4-9,14,17,19-20,23-26,32,38H,10-13,15-16,18H2,1-3H3,(H,35,39)(H2,33,34,36,37)/t20-,23-,24-,25-,26-/m1/s1
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Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50452470
PNG
(CHEMBL4207573)
Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CC2)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C27H33FN6O2/c1-16(15-35)29-26-33-24-12-5-18(17-3-2-4-19(28)13-17)14-23(24)25(34-26)30-20-6-8-21(9-7-20)31-27(36)32-22-10-11-22/h2-5,12-14,16,20-22,35H,6-11,15H2,1H3,(H2,31,32,36)(H2,29,30,33,34)/t16-,20-,21+/m1/s1
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Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452475
PNG
(CHEMBL4218179)
Show SMILES CC(C)[C@@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C29H39FN6O3/c1-17(2)26(16-38)35-29(39)33-23-10-8-22(9-11-23)32-27-24-14-20(19-5-4-6-21(30)13-19)7-12-25(24)34-28(36-27)31-18(3)15-37/h4-7,12-14,17-18,22-23,26,37-38H,8-11,15-16H2,1-3H3,(H2,33,35,39)(H2,31,32,34,36)/t18-,22-,23+,26-/m1/s1
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Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor


(Homo sapiens (Human))
BDBM50452469
PNG
(CHEMBL4210169)
Show SMILES COC[C@@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CC2)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C28H35FN6O2/c1-17(16-37-2)30-27-34-25-13-6-19(18-4-3-5-20(29)14-18)15-24(25)26(35-27)31-21-7-9-22(10-8-21)32-28(36)33-23-11-12-23/h3-6,13-15,17,21-23H,7-12,16H2,1-2H3,(H2,32,33,36)(H2,30,31,34,35)/t17-,21-,22+/m1/s1
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Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 6680-6694 (2017)


Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6
More data for this
Ligand-Target Pair
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