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Compile Data Set for Download or QSAR

Found 28 hits Enz. Inhib. hit(s) with Target = 'Atrial natriuretic peptide receptor 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452453
PNG
(CHEMBL4202512)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)[C@@H](C)CC
Show InChI InChI=1S/C128H205N45O39S2/c1-10-64(7)99-121(209)151-52-94(183)152-66(9)101(189)156-77(36-37-91(130)180)109(197)167-85(56-175)105(193)150-53-96(185)154-78(43-62(3)4)103(191)149-54-97(186)155-89(119(207)164-82(48-92(131)181)114(202)169-86(57-176)116(204)163-81(46-68-25-16-13-17-26-68)113(201)159-74(29-20-40-144-126(136)137)107(195)166-84(123(211)212)47-69-32-34-70(179)35-33-69)60-213-214-61-90(171-118(206)88(59-178)170-117(205)87(58-177)168-108(196)75(30-21-41-145-127(138)139)157-106(194)73(28-19-39-143-125(134)135)158-112(200)79(44-63(5)6)161-102(190)71(129)55-174)120(208)162-80(45-67-23-14-12-15-24-67)104(192)148-50-93(182)147-51-95(184)153-72(27-18-38-142-124(132)133)110(198)173-100(65(8)11-2)122(210)165-83(49-98(187)188)115(203)160-76(111(199)172-99)31-22-42-146-128(140)141/h12-17,23-26,32-35,62-66,71-90,99-100,174-179H,10-11,18-22,27-31,36-61,129H2,1-9H3,(H2,130,180)(H2,131,181)(H,147,182)(H,148,192)(H,149,191)(H,150,193)(H,151,209)(H,152,183)(H,153,184)(H,154,185)(H,155,186)(H,156,189)(H,157,194)(H,158,200)(H,159,201)(H,160,203)(H,161,190)(H,162,208)(H,163,204)(H,164,207)(H,165,210)(H,166,195)(H,167,197)(H,168,196)(H,169,202)(H,170,205)(H,171,206)(H,172,199)(H,173,198)(H,187,188)(H,211,212)(H4,132,133,142)(H4,134,135,143)(H4,136,137,144)(H4,138,139,145)(H4,140,141,146)/t64-,65-,66-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85+,86-,87-,88-,89-,90-,99-,100-/m0/s1
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n/an/an/an/a 1n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50230986
PNG
(CARPERITIDE | Carperitide | SUN-4936)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO
Show InChI InChI=1S/C127H203N45O39S3/c1-9-64(6)99-121(209)150-52-94(182)151-65(7)100(188)155-76(34-35-91(129)179)109(197)167-85(56-174)104(192)149-53-96(184)153-78(43-62(2)3)102(190)148-54-97(185)154-89(119(207)164-82(48-92(130)180)114(202)169-86(57-175)116(204)163-81(46-67-23-14-11-15-24-67)113(201)158-73(27-18-39-143-125(135)136)107(195)166-84(122(210)211)47-68-30-32-69(178)33-31-68)60-213-214-61-90(171-118(206)88(59-177)170-117(205)87(58-176)168-108(196)74(28-19-40-144-126(137)138)156-106(194)72(26-17-38-142-124(133)134)157-112(200)79(44-63(4)5)161-101(189)70(128)55-173)120(208)162-80(45-66-21-12-10-13-22-66)103(191)147-50-93(181)146-51-95(183)152-71(25-16-37-141-123(131)132)105(193)160-77(36-42-212-8)110(198)165-83(49-98(186)187)115(203)159-75(111(199)172-99)29-20-41-145-127(139)140/h10-15,21-24,30-33,62-65,70-90,99,173-178H,9,16-20,25-29,34-61,128H2,1-8H3,(H2,129,179)(H2,130,180)(H,146,181)(H,147,191)(H,148,190)(H,149,192)(H,150,209)(H,151,182)(H,152,183)(H,153,184)(H,154,185)(H,155,188)(H,156,194)(H,157,200)(H,158,201)(H,159,203)(H,160,193)(H,161,189)(H,162,208)(H,163,204)(H,164,207)(H,165,198)(H,166,195)(H,167,197)(H,168,196)(H,169,202)(H,170,205)(H,171,206)(H,172,199)(H,186,187)(H,210,211)(H4,131,132,141)(H4,133,134,142)(H4,135,136,143)(H4,137,138,144)(H4,139,140,145)/t64-,65-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,99-/m0/s1
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n/an/an/an/a 1n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 1762-1769 (2017)


Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50230984
PNG
(CHEMBL4099832)
Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CCCCC1N(C(N)=NC1=O)c1nc(NC(N)=N)nc(Nc2ccc(Nc3nc(NC(N)=N)nc(n3)N3C(CCCC)C(=O)N=C3N)cc2)n1
Show InChI InChI=1/C28H38N20O2.2C2HF3O2/c1-3-5-7-15-17(49)37-21(33)47(15)27-43-23(41-25(45-27)39-19(29)30)35-13-9-11-14(12-10-13)36-24-42-26(40-20(31)32)46-28(44-24)48-16(8-6-4-2)18(50)38-22(48)34;2*3-2(4,5)1(6)7/h9-12,15-16H,3-8H2,1-2H3,(H2,33,37,49)(H2,34,38,50)(H5,29,30,35,39,41,43,45)(H5,31,32,36,40,42,44,46);2*(H,6,7)
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n/an/an/an/a 23n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 1762-1769 (2017)


Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452455
PNG
(CHEMBL4215510)
Show SMILES CC(C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)N[C@@H](CO)C(C)C)c2cc(cnc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C28H38FN7O2/c1-16(2)24(15-37)34-28(38)33-22-10-8-21(9-11-22)32-26-23-13-19(18-6-5-7-20(29)12-18)14-30-25(23)35-27(36-26)31-17(3)4/h5-7,12-14,16-17,21-22,24,37H,8-11,15H2,1-4H3,(H2,33,34,38)(H2,30,31,32,35,36)/t21-,22+,24-/m0/s1
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n/an/an/an/a 43n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452456
PNG
(CHEMBL4206652)
Show SMILES CC(C)[C@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ncc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C28H38FN7O3/c1-16(2)24(15-38)34-28(39)33-22-9-7-21(8-10-22)32-26-23-12-19(18-5-4-6-20(29)11-18)13-30-25(23)35-27(36-26)31-17(3)14-37/h4-6,11-13,16-17,21-22,24,37-38H,7-10,14-15H2,1-3H3,(H2,33,34,39)(H2,30,31,32,35,36)/t17-,21-,22+,24+/m1/s1
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n/an/an/an/a 62n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452457
PNG
(CHEMBL4213559)
Show SMILES CC(C)[C@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C29H39FN6O3/c1-17(2)26(16-38)35-29(39)33-23-10-8-22(9-11-23)32-27-24-14-20(19-5-4-6-21(30)13-19)7-12-25(24)34-28(36-27)31-18(3)15-37/h4-7,12-14,17-18,22-23,26,37-38H,8-11,15-16H2,1-3H3,(H2,33,35,39)(H2,31,32,34,36)/t18-,22-,23+,26+/m1/s1
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n/an/an/an/a 65n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452451
PNG
(CHEMBL4210772)
Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)(C)CO)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C28H37FN6O3/c1-17(15-36)30-26-33-24-12-7-19(18-5-4-6-20(29)13-18)14-23(24)25(34-26)31-21-8-10-22(11-9-21)32-27(38)35-28(2,3)16-37/h4-7,12-14,17,21-22,36-37H,8-11,15-16H2,1-3H3,(H2,32,35,38)(H2,30,31,33,34)/t17-,21-,22+/m1/s1
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n/an/an/an/a 66n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452464
PNG
(CHEMBL4212125)
Show SMILES CC(C)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C27H35FN6O2/c1-16(2)29-27(36)32-22-10-8-21(9-11-22)31-25-23-14-19(18-5-4-6-20(28)13-18)7-12-24(23)33-26(34-25)30-17(3)15-35/h4-7,12-14,16-17,21-22,35H,8-11,15H2,1-3H3,(H2,29,32,36)(H2,30,31,33,34)/t17-,21-,22+/m1/s1
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n/an/an/an/a 74n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50230988
PNG
(CHEMBL4089697)
Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(C)CC1N(C(N)=NC1=O)c1nc(NC2CCC(CC2)Nc2nc(NC(N)=N)nc(n2)N2C(CC(C)C)C(=O)N=C2N)nc(NC(N)=N)n1
Show InChI InChI=1/C28H44N20O2.4C2HF3O2/c1-11(2)9-15-17(49)37-21(33)47(15)27-43-23(41-25(45-27)39-19(29)30)35-13-5-7-14(8-6-13)36-24-42-26(40-20(31)32)46-28(44-24)48-16(10-12(3)4)18(50)38-22(48)34;4*3-2(4,5)1(6)7/h11-16H,5-10H2,1-4H3,(H2,33,37,49)(H2,34,38,50)(H5,29,30,35,39,41,43,45)(H5,31,32,36,40,42,44,46);4*(H,6,7)
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n/an/an/an/a 76n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 1762-1769 (2017)


Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5
More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452458
PNG
(CHEMBL4207138)
Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2(CO)CCCC2)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C30H39FN6O3/c1-19(17-38)32-28-35-26-12-7-21(20-5-4-6-22(31)15-20)16-25(26)27(36-28)33-23-8-10-24(11-9-23)34-29(40)37-30(18-39)13-2-3-14-30/h4-7,12,15-16,19,23-24,38-39H,2-3,8-11,13-14,17-18H2,1H3,(H2,34,37,40)(H2,32,33,35,36)/t19-,23-,24+/m1/s1
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n/an/an/an/a 120n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452454
PNG
(CHEMBL4216406)
Show SMILES CC(C)[C@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2cnc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C28H38FN7O3/c1-16(2)25(15-38)35-28(39)33-21-9-7-20(8-10-21)32-26-22-12-23(18-5-4-6-19(29)11-18)30-13-24(22)34-27(36-26)31-17(3)14-37/h4-6,11-13,16-17,20-21,25,37-38H,7-10,14-15H2,1-3H3,(H2,33,35,39)(H2,31,32,34,36)/t17-,20-,21+,25+/m1/s1
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n/an/an/an/a 130n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452473
PNG
(CHEMBL4205804)
Show SMILES COC[C@@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)C)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C28H37FN6O2/c1-17(2)30-28(36)33-23-11-9-22(10-12-23)32-26-24-15-20(19-6-5-7-21(29)14-19)8-13-25(24)34-27(35-26)31-18(3)16-37-4/h5-8,13-15,17-18,22-23H,9-12,16H2,1-4H3,(H2,30,33,36)(H2,31,32,34,35)/t18-,22-,23+/m1/s1
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n/an/an/an/a 160n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452470
PNG
(CHEMBL4207573)
Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CC2)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C27H33FN6O2/c1-16(15-35)29-26-33-24-12-5-18(17-3-2-4-19(28)13-17)14-23(24)25(34-26)30-20-6-8-21(9-7-20)31-27(36)32-22-10-11-22/h2-5,12-14,16,20-22,35H,6-11,15H2,1H3,(H2,31,32,36)(H2,29,30,33,34)/t16-,20-,21+/m1/s1
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n/an/an/an/a 180n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452469
PNG
(CHEMBL4210169)
Show SMILES COC[C@@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CC2)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C28H35FN6O2/c1-17(16-37-2)30-27-34-25-13-6-19(18-4-3-5-20(29)14-18)15-24(25)26(35-27)31-21-7-9-22(10-8-21)32-28(36)33-23-11-12-23/h3-6,13-15,17,21-23H,7-12,16H2,1-2H3,(H2,32,33,36)(H2,30,31,34,35)/t17-,21-,22+/m1/s1
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n/an/an/an/a 270n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452468
PNG
(CHEMBL4205090)
Show SMILES CC(C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)N[C@@H](CO)C(C)C)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C29H39FN6O2/c1-17(2)26(16-37)35-29(38)33-23-11-9-22(10-12-23)32-27-24-15-20(19-6-5-7-21(30)14-19)8-13-25(24)34-28(36-27)31-18(3)4/h5-8,13-15,17-18,22-23,26,37H,9-12,16H2,1-4H3,(H2,33,35,38)(H2,31,32,34,36)/t22-,23+,26-/m0/s1
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n/an/an/an/a 290n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452475
PNG
(CHEMBL4218179)
Show SMILES CC(C)[C@@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C29H39FN6O3/c1-17(2)26(16-38)35-29(39)33-23-10-8-22(9-11-23)32-27-24-14-20(19-5-4-6-21(30)13-19)7-12-25(24)34-28(36-27)31-18(3)15-37/h4-7,12-14,17-18,22-23,26,37-38H,8-11,15-16H2,1-3H3,(H2,33,35,39)(H2,31,32,34,36)/t18-,22-,23+,26-/m1/s1
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n/an/an/an/a 330n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452459
PNG
(CHEMBL4209646)
Show SMILES CC(C)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(NC(C)C)nc2ccc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C27H35FN6O/c1-16(2)29-26-33-24-13-8-19(18-6-5-7-20(28)14-18)15-23(24)25(34-26)31-21-9-11-22(12-10-21)32-27(35)30-17(3)4/h5-8,13-17,21-22H,9-12H2,1-4H3,(H2,30,32,35)(H2,29,31,33,34)/t21-,22+
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n/an/an/an/a 420n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452465
PNG
(CHEMBL4209251)
Show SMILES CC(C)NC(=O)N[C@H]1CC[C@@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C27H35FN6O2/c1-16(2)29-27(36)32-22-10-8-21(9-11-22)31-25-23-14-19(18-5-4-6-20(28)13-18)7-12-24(23)33-26(34-25)30-17(3)15-35/h4-7,12-14,16-17,21-22,35H,8-11,15H2,1-3H3,(H2,29,32,36)(H2,30,31,33,34)/t17-,21-,22-/m1/s1
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n/an/an/an/a 530n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452461
PNG
(CHEMBL4214047)
Show SMILES COCCNc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)C)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C27H35FN6O2/c1-17(2)30-27(35)32-22-10-8-21(9-11-22)31-25-23-16-19(18-5-4-6-20(28)15-18)7-12-24(23)33-26(34-25)29-13-14-36-3/h4-7,12,15-17,21-22H,8-11,13-14H2,1-3H3,(H2,30,32,35)(H2,29,31,33,34)/t21-,22+
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n/an/an/an/a 610n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452466
PNG
(CHEMBL4205825)
Show SMILES C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)[C@H]2C[C@H](O)C2)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C28H34FN5O3/c1-16(15-35)30-28-33-25-10-5-18(17-3-2-4-20(29)11-17)14-24(25)26(34-28)31-21-6-8-22(9-7-21)32-27(37)19-12-23(36)13-19/h2-5,10-11,14,16,19,21-23,35-36H,6-9,12-13,15H2,1H3,(H,32,37)(H2,30,31,33,34)/t16-,19-,21-,22-,23-/m1/s1
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n/an/an/an/a 700n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452452
PNG
(CHEMBL4204379)
Show SMILES C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)N2CC(O)C2)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C27H33FN6O3/c1-16(15-35)29-26-32-24-10-5-18(17-3-2-4-19(28)11-17)12-23(24)25(33-26)30-20-6-8-21(9-7-20)31-27(37)34-13-22(36)14-34/h2-5,10-12,16,20-22,35-36H,6-9,13-15H2,1H3,(H,31,37)(H2,29,30,32,33)/t16-,20-,21-/m1/s1
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n/an/an/an/a 900n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452472
PNG
(CHEMBL4212627)
Show SMILES COC[C@@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)C)c2nc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C27H36FN7O2/c1-16(2)29-27(36)32-21-10-8-20(9-11-21)31-25-24-23(34-26(35-25)30-17(3)15-37-4)13-12-22(33-24)18-6-5-7-19(28)14-18/h5-7,12-14,16-17,20-21H,8-11,15H2,1-4H3,(H2,29,32,36)(H2,30,31,34,35)/t17-,20-,21+/m1/s1
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n/an/an/an/a 1.60E+3n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452474
PNG
(CHEMBL4217523)
Show SMILES C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)[C@H]2C[C@H](O)C2)c2cc(ccc2n1)-c1ccccc1
Show InChI InChI=1S/C28H35N5O3/c1-17(16-34)29-28-32-25-12-7-19(18-5-3-2-4-6-18)15-24(25)26(33-28)30-21-8-10-22(11-9-21)31-27(36)20-13-23(35)14-20/h2-7,12,15,17,20-23,34-35H,8-11,13-14,16H2,1H3,(H,31,36)(H2,29,30,32,33)/t17-,20-,21-,22-,23-/m1/s1
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n/an/an/an/a 1.80E+3n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452462
PNG
(CHEMBL4217505)
Show SMILES COC[C@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CC2)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C28H35FN6O2/c1-17(16-37-2)30-27-34-25-13-6-19(18-4-3-5-20(29)14-18)15-24(25)26(35-27)31-21-7-9-22(10-8-21)32-28(36)33-23-11-12-23/h3-6,13-15,17,21-23H,7-12,16H2,1-2H3,(H2,32,33,36)(H2,30,31,34,35)/t17-,21-,22+/m0/s1
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n/an/an/an/a 1.80E+3n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452467
PNG
(CHEMBL4218032)
Show SMILES CC(C)N[C@H]1C[C@@H](C1)C(=O)N[C@H]1CC[C@@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C31H42N6O2/c1-19(2)32-26-15-23(16-26)30(39)35-25-12-10-24(11-13-25)34-29-27-17-22(21-7-5-4-6-8-21)9-14-28(27)36-31(37-29)33-20(3)18-38/h4-9,14,17,19-20,23-26,32,38H,10-13,15-16,18H2,1-3H3,(H,35,39)(H2,33,34,36,37)/t20-,23-,24-,25-,26-/m1/s1
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n/an/an/an/a 2.00E+3n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452460
PNG
(CHEMBL4218972)
Show SMILES CC(C)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(nc2ccc(cc12)-c1cccc(F)c1)N(C)CCO
Show InChI InChI=1S/C27H35FN6O2/c1-17(2)29-27(36)31-22-10-8-21(9-11-22)30-25-23-16-19(18-5-4-6-20(28)15-18)7-12-24(23)32-26(33-25)34(3)13-14-35/h4-7,12,15-17,21-22,35H,8-11,13-14H2,1-3H3,(H2,29,31,36)(H,30,32,33)/t21-,22+
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n/an/an/an/a 2.10E+3n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452471
PNG
(CHEMBL4214562)
Show SMILES CC(C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)N(C)C(C)C)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C28H37FN6O/c1-17(2)30-27-33-25-14-9-20(19-7-6-8-21(29)15-19)16-24(25)26(34-27)31-22-10-12-23(13-11-22)32-28(36)35(5)18(3)4/h6-9,14-18,22-23H,10-13H2,1-5H3,(H,32,36)(H2,30,31,33,34)/t22-,23+
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n/an/an/an/a 3.00E+3n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair
Atrial natriuretic peptide receptor 1


(Rattus norvegicus)
BDBM50452463
PNG
(CHEMBL4206328)
Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CCCN(C)C2)c2cc(ccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C30H40FN7O2/c1-19(18-39)32-29-36-27-13-8-21(20-5-3-6-22(31)15-20)16-26(27)28(37-29)33-23-9-11-24(12-10-23)34-30(40)35-25-7-4-14-38(2)17-25/h3,5-6,8,13,15-16,19,23-25,39H,4,7,9-12,14,17-18H2,1-2H3,(H2,34,35,40)(H2,32,33,36,37)/t19-,23-,24+,25?/m1/s1
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n/an/an/an/a 3.20E+3n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay


Bioorg Med Chem 25: 6680-6694 (2017)

More data for this
Ligand-Target Pair