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Compile Data Set for Download or QSAR

Found 2106 hits Enz. Inhib. hit(s) with Target = 'CREB-binding protein'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50463353
PNG
(CHEMBL4248974)
Show SMILES CN1CCN(c2ccccc12)S(=O)(=O)c1ccc(cc1)N1CCCC1=O
Show InChI InChI=1S/C19H21N3O3S/c1-20-13-14-22(18-6-3-2-5-17(18)20)26(24,25)16-10-8-15(9-11-16)21-12-4-7-19(21)23/h2-3,5-6,8-11H,4,7,12-14H2,1H3
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n/an/an/an/a 2n/an/an/an/a



Human BioMolecular Research Institute

Curated by ChEMBL


Assay Description
Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...


Bioorg Med Chem 26: 4441-4451 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50463352
PNG
(CHEMBL4238053)
Show SMILES COc1ccc2N(CCN(C)c2c1)S(=O)(=O)c1ccc(cc1)N1CCCC1=O
Show InChI InChI=1S/C20H23N3O4S/c1-21-12-13-23(18-10-7-16(27-2)14-19(18)21)28(25,26)17-8-5-15(6-9-17)22-11-3-4-20(22)24/h5-10,14H,3-4,11-13H2,1-2H3
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n/an/an/an/a 4n/an/an/an/a



Human BioMolecular Research Institute

Curated by ChEMBL


Assay Description
Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...


Bioorg Med Chem 26: 4441-4451 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50463354
PNG
(CHEMBL4246320)
Show SMILES Cc1ccc2N(CCCc2c1)S(=O)(=O)c1ccc(cc1)N1CCCC1=O
Show InChI InChI=1S/C20H22N2O3S/c1-15-6-11-19-16(14-15)4-2-13-22(19)26(24,25)18-9-7-17(8-10-18)21-12-3-5-20(21)23/h6-11,14H,2-5,12-13H2,1H3
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n/an/an/an/a 4n/an/an/an/a



Human BioMolecular Research Institute

Curated by ChEMBL


Assay Description
Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...


Bioorg Med Chem 26: 4441-4451 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50269847
PNG
(CHEMBL4097025)
Show SMILES CNC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C27H33F2N7O2/c1-30-27(37)34-9-5-23-22(16-34)26(32-36(23)19-6-10-38-11-7-19)35-8-3-4-17-12-20(18-14-31-33(2)15-18)21(25(28)29)13-24(17)35/h12-15,19,25H,3-11,16H2,1-2H3,(H,30,37)
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n/an/an/an/a 6.60n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of CBP in human MV-4-11 cells assessed as decrease in MYC expression incubated for 4 hrs measured by luminescence method


J Med Chem 60: 9162-9183 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50453957
PNG
(CHEMBL4217213)
Show SMILES CNC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1cccc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C28H30F2N6O2/c1-31-28(37)35-9-6-25-24(16-35)26(33-36(25)19-7-10-38-11-8-19)20-5-3-4-17-12-21(18-14-32-34(2)15-18)23(27(29)30)13-22(17)20/h3-5,12-15,19,27H,6-11,16H2,1-2H3,(H,31,37)
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n/an/an/an/a 6.60n/an/an/an/a



WuXi AppTec Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expression


Bioorg Med Chem Lett 28: 15-23 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50463359
PNG
(CHEMBL4243509)
Show SMILES COc1ccc2N(CCCc2c1)S(=O)(=O)c1ccc(cc1)N1CCCC1=O
Show InChI InChI=1S/C20H22N2O4S/c1-26-17-8-11-19-15(14-17)4-2-13-22(19)27(24,25)18-9-6-16(7-10-18)21-12-3-5-20(21)23/h6-11,14H,2-5,12-13H2,1H3
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n/an/an/an/a 9n/an/an/an/a



Human BioMolecular Research Institute

Curated by ChEMBL


Assay Description
Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...


Bioorg Med Chem 26: 4441-4451 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50463351
PNG
(CHEMBL4240212)
Show SMILES O=C1CCCN1c1ccc(cc1)S(=O)(=O)N1CCCc2ccccc12
Show InChI InChI=1S/C19H20N2O3S/c22-19-8-4-13-20(19)16-9-11-17(12-10-16)25(23,24)21-14-3-6-15-5-1-2-7-18(15)21/h1-2,5,7,9-12H,3-4,6,8,13-14H2
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n/an/an/an/a 12n/an/an/an/a



Human BioMolecular Research Institute

Curated by ChEMBL


Assay Description
Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...


Bioorg Med Chem 26: 4441-4451 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50250911
PNG
(CHEMBL4095153)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3cc(N4CCOCC4)c4n(C)c(=O)n(C)c4c3)c2cc1C(F)F
Show InChI InChI=1S/C27H30F2N6O2/c1-31-16-18(15-30-31)20-11-17-5-4-6-35(22(17)14-21(20)26(28)29)19-12-23-25(33(3)27(36)32(23)2)24(13-19)34-7-9-37-10-8-34/h11-16,26H,4-10H2,1-3H3
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n/an/an/an/a 12n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assay


J Med Chem 60: 10151-10171 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50269849
PNG
(CHEMBL4076748)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C27H32F2N6O2/c1-17(36)33-9-5-24-23(16-33)27(31-35(24)20-6-10-37-11-7-20)34-8-3-4-18-12-21(19-14-30-32(2)15-19)22(26(28)29)13-25(18)34/h12-15,20,26H,3-11,16H2,1-2H3
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n/an/an/an/a 14n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of CBP in human MV-4-11 cells assessed as decrease in MYC expression incubated for 4 hrs measured by luminescence method


J Med Chem 60: 9162-9183 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50463353
PNG
(CHEMBL4248974)
Show SMILES CN1CCN(c2ccccc12)S(=O)(=O)c1ccc(cc1)N1CCCC1=O
Show InChI InChI=1S/C19H21N3O3S/c1-20-13-14-22(18-6-3-2-5-17(18)20)26(24,25)16-10-8-15(9-11-16)21-12-4-7-19(21)23/h2-3,5-6,8-11H,4,7,12-14H2,1H3
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n/an/an/an/a 18n/an/an/an/a



Human BioMolecular Research Institute

Curated by ChEMBL


Assay Description
Activation of p53 in human MCF7 cell lysates assessed as increase in total p53 protein level by Western blot analysis


Bioorg Med Chem 26: 4441-4451 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50453949
PNG
(CHEMBL4208820)
Show SMILES CNC(=O)c1ccc(cn1)-c1cc2cccc(-c3nn(C4CCOCC4)c4CCN(Cc34)C(C)=O)c2cn1
Show InChI InChI=1S/C29H30N6O3/c1-18(36)34-11-8-27-24(17-34)28(33-35(27)21-9-12-38-13-10-21)22-5-3-4-19-14-26(32-16-23(19)22)20-6-7-25(31-15-20)29(37)30-2/h3-7,14-16,21H,8-13,17H2,1-2H3,(H,30,37)
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n/an/an/an/a 18n/an/an/an/a



WuXi AppTec Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expression


Bioorg Med Chem Lett 28: 15-23 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50453950
PNG
(CHEMBL4203082)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1cccc2cc(ncc12)-c1cnn(C)c1
Show InChI InChI=1S/C26H28N6O2/c1-17(33)31-9-6-25-23(16-31)26(29-32(25)20-7-10-34-11-8-20)21-5-3-4-18-12-24(27-14-22(18)21)19-13-28-30(2)15-19/h3-5,12-15,20H,6-11,16H2,1-2H3
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n/an/an/an/a 32n/an/an/an/a



WuXi AppTec Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expression


Bioorg Med Chem Lett 28: 15-23 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50250892
PNG
(CHEMBL4061254)
Show SMILES CNC(=O)c1c[nH]c2c(nc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F)C(C)C
Show InChI InChI=1S/C26H28F2N6O/c1-14(2)23-24-18(20(12-30-24)26(35)29-3)10-22(32-23)34-7-5-6-15-8-17(16-11-31-33(4)13-16)19(25(27)28)9-21(15)34/h8-14,25,30H,5-7H2,1-4H3,(H,29,35)
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n/an/an/an/a 53n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of human TNKS2 (873 to 1162 residues) assessed as reduction in NAD+ consumption by fluorescence assay


J Med Chem 60: 10151-10171 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50463358
PNG
(CHEMBL4244338)
Show SMILES CN1CCN(c2ccccc12)S(=O)(=O)c1ccc(cc1)N1CCCC1
Show InChI InChI=1S/C19H23N3O2S/c1-20-14-15-22(19-7-3-2-6-18(19)20)25(23,24)17-10-8-16(9-11-17)21-12-4-5-13-21/h2-3,6-11H,4-5,12-15H2,1H3
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n/an/an/an/a 65n/an/an/an/a



Human BioMolecular Research Institute

Curated by ChEMBL


Assay Description
Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...


Bioorg Med Chem 26: 4441-4451 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50200384
PNG
(CHEMBL3968533 | US9763922, Example 299)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cnn(C)c1)nn2[C@@H]1CCOC1
Show InChI InChI=1/C22H25FN6O2/c1-14(30)28-7-5-21-18(12-28)22(26-29(21)17-6-8-31-13-17)25-20-4-3-15(9-19(20)23)16-10-24-27(2)11-16/h3-4,9-11,17H,5-8,12-13H2,1-2H3,(H,25,26)/t17-/s2
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n/an/an/an/a 69n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of CBP/EP300 in human MOLM16 cells assessed as decrease in MYC expression measured after 4 hrs by RT-PCR analysis


J Med Chem 59: 10549-10563 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01022
BindingDB Entry DOI: 10.7270/Q27083DF
More data for this
Ligand-Target Pair
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50463356
PNG
(CHEMBL4240141)
Show SMILES CN1CCN(c2ccccc12)S(=O)(=O)c1ccc(cc1)N1CCC=N1
Show InChI InChI=1S/C18H20N4O2S/c1-20-13-14-22(18-6-3-2-5-17(18)20)25(23,24)16-9-7-15(8-10-16)21-12-4-11-19-21/h2-3,5-11H,4,12-14H2,1H3
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n/an/an/an/a 74n/an/an/an/a



Human BioMolecular Research Institute

Curated by ChEMBL


Assay Description
Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...


Bioorg Med Chem 26: 4441-4451 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50453948
PNG
(CHEMBL4204490)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1cccc2cc(ncc12)-c1cnn(C)c1C#N
Show InChI InChI=1S/C27H27N7O2/c1-17(35)33-9-6-25-23(16-33)27(31-34(25)19-7-10-36-11-8-19)20-5-3-4-18-12-24(29-14-21(18)20)22-15-30-32(2)26(22)13-28/h3-5,12,14-15,19H,6-11,16H2,1-2H3
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n/an/an/an/a 76n/an/an/an/a



WuXi AppTec Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expression


Bioorg Med Chem Lett 28: 15-23 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50453970
PNG
(CHEMBL4207965)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1cccc2cc(ncc12)-c1cnn(C)c1C(F)F
Show InChI InChI=1S/C27H28F2N6O2/c1-16(36)34-9-6-24-22(15-34)25(32-35(24)18-7-10-37-11-8-18)19-5-3-4-17-12-23(30-13-20(17)19)21-14-31-33(2)26(21)27(28)29/h3-5,12-14,18,27H,6-11,15H2,1-2H3
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WuXi AppTec Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expression


Bioorg Med Chem Lett 28: 15-23 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50463355
PNG
(CHEMBL4240977)
Show SMILES CC(C)(C)c1ccc2N(CCCc2c1)S(=O)(=O)c1ccc(cc1)N1CCCC1=O
Show InChI InChI=1S/C23H28N2O3S/c1-23(2,3)18-8-13-21-17(16-18)6-4-15-25(21)29(27,28)20-11-9-19(10-12-20)24-14-5-7-22(24)26/h8-13,16H,4-7,14-15H2,1-3H3
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n/an/an/an/a 152n/an/an/an/a



Human BioMolecular Research Institute

Curated by ChEMBL


Assay Description
Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...


Bioorg Med Chem 26: 4441-4451 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50463357
PNG
(CHEMBL4243377)
Show SMILES CCCN(c1ccccc1)S(=O)(=O)c1ccc(cc1)N1CCCC1=O
Show InChI InChI=1S/C19H22N2O3S/c1-2-14-21(17-7-4-3-5-8-17)25(23,24)18-12-10-16(11-13-18)20-15-6-9-19(20)22/h3-5,7-8,10-13H,2,6,9,14-15H2,1H3
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n/an/an/an/a 158n/an/an/an/a



Human BioMolecular Research Institute

Curated by ChEMBL


Assay Description
Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...


Bioorg Med Chem 26: 4441-4451 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50453976
PNG
(CHEMBL4209361)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1cccc2cc(ncc12)-c1cn(C)nc1C(F)F
Show InChI InChI=1S/C27H28F2N6O2/c1-16(36)34-9-6-24-22(15-34)25(32-35(24)18-7-10-37-11-8-18)19-5-3-4-17-12-23(30-13-20(17)19)21-14-33(2)31-26(21)27(28)29/h3-5,12-14,18,27H,6-11,15H2,1-2H3
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WuXi AppTec Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expression


Bioorg Med Chem Lett 28: 15-23 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50453971
PNG
(CHEMBL4204065)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1cccc2cc(ncc12)-c1cn(C)nc1C#N
Show InChI InChI=1S/C27H27N7O2/c1-17(35)33-9-6-26-23(16-33)27(31-34(26)19-7-10-36-11-8-19)20-5-3-4-18-12-24(29-14-21(18)20)22-15-32(2)30-25(22)13-28/h3-5,12,14-15,19H,6-11,16H2,1-2H3
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n/an/an/an/a 280n/an/an/an/a



WuXi AppTec Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expression


Bioorg Med Chem Lett 28: 15-23 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178219
PNG
(CHEMBL3814752)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(-c5cnn(C)c5)c4c3)c2N1
Show InChI InChI=1/C22H22N6O/c1-13-9-20(29)25-18-6-4-5-16(22(18)24-13)14-7-8-19-17(10-14)21(26-28(19)3)15-11-23-27(2)12-15/h4-8,10-13,24H,9H2,1-3H3,(H,25,29)/t13-/s2
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n/an/an/an/a 300n/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50250913
PNG
(CHEMBL4073812)
Show SMILES CNC(=O)c1c[nH]c2cnc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C23H22F2N6O/c1-26-23(32)18-10-27-19-11-28-21(8-16(18)19)31-5-3-4-13-6-15(14-9-29-30(2)12-14)17(22(24)25)7-20(13)31/h6-12,22,27H,3-5H2,1-2H3,(H,26,32)
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n/an/an/an/a 360n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assay


J Med Chem 60: 10151-10171 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50200445
PNG
(CHEMBL3897393 | US9763922, Example 300)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cnn(C)c1)nn2[C@H]1CCOC1
Show InChI InChI=1/C22H25FN6O2/c1-14(30)28-7-5-21-18(12-28)22(26-29(21)17-6-8-31-13-17)25-20-4-3-15(9-19(20)23)16-10-24-27(2)11-16/h3-4,9-11,17H,5-8,12-13H2,1-2H3,(H,25,26)/t17-/s2
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n/an/an/an/a 910n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of CBP in human MV-4-11 cells assessed as decrease in MYC expression incubated for 4 hrs measured by luminescence method


J Med Chem 60: 9162-9183 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50200384
PNG
(CHEMBL3968533 | US9763922, Example 299)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cnn(C)c1)nn2[C@@H]1CCOC1
Show InChI InChI=1/C22H25FN6O2/c1-14(30)28-7-5-21-18(12-28)22(26-29(21)17-6-8-31-13-17)25-20-4-3-15(9-19(20)23)16-10-24-27(2)11-16/h3-4,9-11,17H,5-8,12-13H2,1-2H3,(H,25,26)/t17-/s2
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n/an/an/an/a 910n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of CBP/EP300 in human MV4-11 cells assessed as inhibition of MYC expression measured after 4 hrs by luminescence analysis


J Med Chem 59: 10549-10563 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01022
BindingDB Entry DOI: 10.7270/Q27083DF
More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50250910
PNG
(CHEMBL4072630)
Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3ccc4n(C)c(=O)n(C)c4c3)c2cc1C(F)F
Show InChI InChI=1S/C23H23F2N5O/c1-27-13-15(12-26-27)17-9-14-5-4-8-30(20(14)11-18(17)22(24)25)16-6-7-19-21(10-16)29(3)23(31)28(19)2/h6-7,9-13,22H,4-5,8H2,1-3H3
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n/an/an/an/a 1.00E+3n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assay


J Med Chem 60: 10151-10171 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178169
PNG
(CHEMBL3814896 | US10206931, Example 75)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(C(=O)Nc3cccc(c3)-c3cnco3)c2N1
Show InChI InChI=1/C20H18N4O3/c1-12-8-18(25)24-16-7-3-6-15(19(16)22-12)20(26)23-14-5-2-4-13(9-14)17-10-21-11-27-17/h2-7,9-12,22H,8H2,1H3,(H,23,26)(H,24,25)/t12-/s2
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n/an/an/an/a 1.20E+3n/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50200445
PNG
(CHEMBL3897393 | US9763922, Example 300)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cnn(C)c1)nn2[C@H]1CCOC1
Show InChI InChI=1/C22H25FN6O2/c1-14(30)28-7-5-21-18(12-28)22(26-29(21)17-6-8-31-13-17)25-20-4-3-15(9-19(20)23)16-10-24-27(2)11-16/h3-4,9-11,17H,5-8,12-13H2,1-2H3,(H,25,26)/t17-/s2
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n/an/an/an/a 1.90E+3n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of CBP/EP300 in human MV4-11 cells assessed as inhibition of MYC expression measured after 4 hrs by luminescence analysis


J Med Chem 59: 10549-10563 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01022
BindingDB Entry DOI: 10.7270/Q27083DF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50178161
PNG
(CHEMBL3813929)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(C(N)=O)c4c3)c2N1
Show InChI InChI=1/C19H19N5O2/c1-10-8-16(25)22-14-5-3-4-12(17(14)21-10)11-6-7-15-13(9-11)18(19(20)26)23-24(15)2/h3-7,9-10,21H,8H2,1-2H3,(H2,20,26)(H,22,25)/t10-/s2
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n/an/an/an/a 1.90E+3n/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50250896
PNG
(CHEMBL4065346)
Show SMILES CNC(=O)c1c[nH]c2ccc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Show InChI InChI=1S/C24H23F2N5O/c1-27-24(32)20-12-28-21-6-5-16(9-18(20)21)31-7-3-4-14-8-17(15-11-29-30(2)13-15)19(23(25)26)10-22(14)31/h5-6,8-13,23,28H,3-4,7H2,1-2H3,(H,27,32)
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n/an/an/an/a 2.20E+3n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assay


J Med Chem 60: 10151-10171 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50178220
PNG
(CHEMBL3814550 | US10206931, Example 57)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(C5CC5)c4c3)c2N1
Show InChI InChI=1/C21H22N4O/c1-12-10-19(26)23-17-5-3-4-15(21(17)22-12)14-8-9-18-16(11-14)20(13-6-7-13)24-25(18)2/h3-5,8-9,11-13,22H,6-7,10H2,1-2H3,(H,23,26)/t12-/s2
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n/an/an/an/a 3.00E+3n/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50178164
PNG
(CHEMBL3815023 | US10206931, Example 173)
Show SMILES CC(c1ccccc1)n1cc(cn1)-c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1/C21H22N4O/c1-14-11-20(26)24-19-10-6-9-18(21(19)23-14)17-12-22-25(13-17)15(2)16-7-4-3-5-8-16/h3-10,12-15,23H,11H2,1-2H3,(H,24,26)/t14-,15?/s2
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n/an/an/an/a 3.40E+3n/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50463350
PNG
(CHEMBL4243580)
Show SMILES O=S(=O)(N1CCCc2ccccc12)c1ccc(cc1)-n1cncn1
Show InChI InChI=1S/C17H16N4O2S/c22-24(23,21-11-3-5-14-4-1-2-6-17(14)21)16-9-7-15(8-10-16)20-13-18-12-19-20/h1-2,4,6-10,12-13H,3,5,11H2
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n/an/an/an/a>5.00E+3n/an/an/an/a



Human BioMolecular Research Institute

Curated by ChEMBL


Assay Description
Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...


Bioorg Med Chem 26: 4441-4451 (2018)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178168
PNG
(CHEMBL3814246 | US10206931, Example 176)
Show SMILES COc1ccc(cc1OC)-c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1/C18H20N2O3/c1-11-9-17(21)20-14-6-4-5-13(18(14)19-11)12-7-8-15(22-2)16(10-12)23-3/h4-8,10-11,19H,9H2,1-3H3,(H,20,21)/t11-/s2
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n/an/an/an/a 5.00E+3n/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM188517
PNG
(PF-CBP1)
Show SMILES CCCOc1ccc(CCc2nc3cc(ccc3n2CCN2CCOCC2)-c2c(C)noc2C)cc1
Show InChI InChI=1S/C29H36N4O3/c1-4-17-35-25-9-5-23(6-10-25)7-12-28-30-26-20-24(29-21(2)31-36-22(29)3)8-11-27(26)33(28)14-13-32-15-18-34-19-16-32/h5-6,8-11,20H,4,7,12-19H2,1-3H3
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n/an/an/an/a 6.60E+3n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of CBP/EP300 (unknown origin) assessed as reduction in MYC expression by cell based assay


J Med Chem 59: 10549-10563 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01022
BindingDB Entry DOI: 10.7270/Q27083DF
More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM188519
PNG
(SGC-CBP30)
Show SMILES COc1ccc(CCc2nc3cc(ccc3n2C[C@H](C)N2CCOCC2)-c2c(C)noc2C)cc1Cl
Show InChI InChI=1/C28H33ClN4O3/c1-18(32-11-13-35-14-12-32)17-33-25-8-7-22(28-19(2)31-36-20(28)3)16-24(25)30-27(33)10-6-21-5-9-26(34-4)23(29)15-21/h5,7-9,15-16,18H,6,10-14,17H2,1-4H3/t18-/s2
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n/an/an/an/a 6.90E+3n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of CBP/EP300 (unknown origin) assessed as reduction in MYC expression by cell based assay


J Med Chem 59: 10549-10563 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01022
BindingDB Entry DOI: 10.7270/Q27083DF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50178221
PNG
(CHEMBL3814602)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(C#N)c4c3)c2N1
Show InChI InChI=1/C19H17N5O/c1-11-8-18(25)22-15-5-3-4-13(19(15)21-11)12-6-7-17-14(9-12)16(10-20)23-24(17)2/h3-7,9,11,21H,8H2,1-2H3,(H,22,25)/t11-/s2
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n/an/an/an/a 7.00E+3n/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178162
PNG
(CHEMBL3814197)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)ncc4c3)c2N1
Show InChI InChI=1/C18H18N4O/c1-11-8-17(23)21-15-5-3-4-14(18(15)20-11)12-6-7-16-13(9-12)10-19-22(16)2/h3-7,9-11,20H,8H2,1-2H3,(H,21,23)/t11-/s2
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n/an/an/an/a 8.10E+3n/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178163
PNG
(CHEMBL3813846 | US10206931, Example 286)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3cccc(OCc4ccccc4)c3)c2N1
Show InChI InChI=1/C23H22N2O2/c1-16-13-22(26)25-21-12-6-11-20(23(21)24-16)18-9-5-10-19(14-18)27-15-17-7-3-2-4-8-17/h2-12,14,16,24H,13,15H2,1H3,(H,25,26)/t16-/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50178170
PNG
(CHEMBL3814881)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(C(=O)NC3CCOc4ccccc34)c2N1
Show InChI InChI=1/C20H21N3O3/c1-12-11-18(24)22-16-7-4-6-14(19(16)21-12)20(25)23-15-9-10-26-17-8-3-2-5-13(15)17/h2-8,12,15,21H,9-11H2,1H3,(H,22,24)(H,23,25)/t12-,15?/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178175
PNG
(CHEMBL3813915)
Show SMILES CC[C@@H](NC(=O)c1cccc2NC(=O)C[C@@H](C)Nc12)c1cnco1
Show InChI InChI=1/C17H20N4O3/c1-3-12(14-8-18-9-24-14)21-17(23)11-5-4-6-13-16(11)19-10(2)7-15(22)20-13/h4-6,8-10,12,19H,3,7H2,1-2H3,(H,20,22)(H,21,23)/t10-,12-/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178180
PNG
(CHEMBL3815086)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(C(=O)NCc3cnco3)c2N1
Show InChI InChI=1/C15H16N4O3/c1-9-5-13(20)19-12-4-2-3-11(14(12)18-9)15(21)17-7-10-6-16-8-22-10/h2-4,6,8-9,18H,5,7H2,1H3,(H,17,21)(H,19,20)/t9-/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178181
PNG
(CHEMBL3813744)
Show SMILES C[C@H](NC(=O)c1cccc2NC(=O)C[C@@H](C)Nc12)c1ccccc1
Show InChI InChI=1/C19H21N3O2/c1-12-11-17(23)22-16-10-6-9-15(18(16)20-12)19(24)21-13(2)14-7-4-3-5-8-14/h3-10,12-13,20H,11H2,1-2H3,(H,21,24)(H,22,23)/t12-,13+/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178183
PNG
(CHEMBL3813713)
Show SMILES C[C@@H](NC(=O)c1cccc2NC(=O)C[C@@H](C)Nc12)c1ccccc1
Show InChI InChI=1/C19H21N3O2/c1-12-11-17(23)22-16-10-6-9-15(18(16)20-12)19(24)21-13(2)14-7-4-3-5-8-14/h3-10,12-13,20H,11H2,1-2H3,(H,21,24)(H,22,23)/t12-,13-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50151663
PNG
(CHEMBL3774655)
Show SMILES CCC(=O)N1CCOc2c(C1)cc(cc2OC[C@H]1CCCN(C)C1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1/C27H36N2O5/c1-5-26(30)29-11-12-33-27-22(17-29)13-21(20-8-9-23(31-3)24(14-20)32-4)15-25(27)34-18-19-7-6-10-28(2)16-19/h8-9,13-15,19H,5-7,10-12,16-18H2,1-4H3/t19-/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of CBP/EP300 (unknown origin) assessed as reduction in MYC expression by cell based assay


J Med Chem 59: 10549-10563 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01022
BindingDB Entry DOI: 10.7270/Q27083DF
More data for this
Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50151661
PNG
(CHEMBL3752296)
Show SMILES COc1ccc2CCCN(CCCNC(=O)c3cccc4NC(=O)[C@@H](C)Nc34)c2c1
Show InChI InChI=1/C23H28N4O3/c1-15-22(28)26-19-8-3-7-18(21(19)25-15)23(29)24-11-5-13-27-12-4-6-16-9-10-17(30-2)14-20(16)27/h3,7-10,14-15,25H,4-6,11-13H2,1-2H3,(H,24,29)(H,26,28)/t15-/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of CBP/EP300 (unknown origin) assessed as reduction in MYC expression by cell based assay


J Med Chem 59: 10549-10563 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01022
BindingDB Entry DOI: 10.7270/Q27083DF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50178218
PNG
(CHEMBL3814595)
Show SMILES C[C@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(-c5cnn(C)c5)c4c3)c2N1
Show InChI InChI=1/C22H22N6O/c1-13-9-20(29)25-18-6-4-5-16(22(18)24-13)14-7-8-19-17(10-14)21(26-28(19)3)15-11-23-27(2)12-15/h4-8,10-13,24H,9H2,1-3H3,(H,25,29)/t13-/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50443232
PNG
(CHEMBL3086883)
Show SMILES Cc1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)c(N)cc1O
Show InChI InChI=1S/C18H17N5O3S/c1-12-10-16(15(19)11-17(12)24)22-21-13-5-7-14(8-6-13)27(25,26)23-18-4-2-3-9-20-18/h2-11,24H,19H2,1H3,(H,20,23)/b22-21+
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2.18E+3n/an/an/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Displacement of fluorescein-labeled MS226 from recombinant human CBP bromodomain after 1 hr by fluorescence anisotropy assay


J Med Chem 56: 9251-64 (2013)


Article DOI: 10.1021/jm401334s
BindingDB Entry DOI: 10.7270/Q2ZW1NCF
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50443231
PNG
(CHEMBL3086884)
Show SMILES Cc1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)c(N)c(C)c1O
Show InChI InChI=1S/C19H19N5O3S/c1-12-11-16(18(20)13(2)19(12)25)23-22-14-6-8-15(9-7-14)28(26,27)24-17-5-3-4-10-21-17/h3-11,25H,20H2,1-2H3,(H,21,24)/b23-22+
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5.12E+3n/an/an/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Displacement of fluorescein-labeled MS226 from recombinant human CBP bromodomain after 1 hr by fluorescence anisotropy assay


J Med Chem 56: 9251-64 (2013)


Article DOI: 10.1021/jm401334s
BindingDB Entry DOI: 10.7270/Q2ZW1NCF
More data for this
Ligand-Target Pair
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