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Found 820 hits Enz. Inhib. hit(s) with Target = 'Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289639
PNG
(9-(4-Fluorobenzyl)-6-(4-methoxybenzyl)-8,9,10,11-t...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5ccc(F)cc5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C25H22FN5O2S/c1-33-19-8-4-17(5-9-19)13-30-24-22(23-27-15-28-31(23)25(30)32)20-10-11-29(14-21(20)34-24)12-16-2-6-18(26)7-3-16/h2-9,15H,10-14H2,1H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289640
PNG
(9-(2-Fluorobenzyl)-6-(4-methoxybenzyl)-8,9,10,11-t...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5ccccc5F)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C25H22FN5O2S/c1-33-18-8-6-16(7-9-18)12-30-24-22(23-27-15-28-31(23)25(30)32)19-10-11-29(14-21(19)34-24)13-17-4-2-3-5-20(17)26/h2-9,15H,10-14H2,1H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289641
PNG
(6-(4-Chloro-2-fluorobenzyl)-9-((tetrahydro-2H-pyra...)
Show SMILES Fc1cc(Cl)ccc1Cn1c2sc3CN(CC4CCOCC4)CCc3c2c2ncnn2c1=O
Show InChI InChI=1S/C23H23ClFN5O2S/c24-16-2-1-15(18(25)9-16)11-29-22-20(21-26-13-27-30(21)23(29)31)17-3-6-28(12-19(17)33-22)10-14-4-7-32-8-5-14/h1-2,9,13-14H,3-8,10-12H2
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289642
PNG
(6-(4-Chloro-2-fluorobenzyl)-9-(pyridin-2-ylmethyl)...)
Show SMILES Fc1cc(Cl)ccc1Cn1c2sc3CN(Cc4ccccn4)CCc3c2c2ncnn2c1=O
Show InChI InChI=1S/C23H18ClFN6OS/c24-15-5-4-14(18(25)9-15)10-30-22-20(21-27-13-28-31(21)23(30)32)17-6-8-29(12-19(17)33-22)11-16-3-1-2-7-26-16/h1-5,7,9,13H,6,8,10-12H2
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289643
PNG
(6-(4-Chloro-2-fluorobenzyl)-9-(1-methyl-1H-imidazo...)
Show SMILES Cn1ccnc1CN1CCc2c(C1)sc1n(Cc3ccc(Cl)cc3F)c(=O)n3ncnc3c21
Show InChI InChI=1S/C22H19ClFN7OS/c1-28-7-5-25-18(28)11-29-6-4-15-17(10-29)33-21-19(15)20-26-12-27-31(20)22(32)30(21)9-13-2-3-14(23)8-16(13)24/h2-3,5,7-8,12H,4,6,9-11H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289644
PNG
(6-(4-Chloro-2-fluorobenzyl)-9-(pyrimidin-2-ylmethy...)
Show SMILES Fc1cc(Cl)ccc1Cn1c2sc3CN(Cc4ncccn4)CCc3c2c2ncnn2c1=O
Show InChI InChI=1S/C22H17ClFN7OS/c23-14-3-2-13(16(24)8-14)9-30-21-19(20-27-12-28-31(20)22(30)32)15-4-7-29(10-17(15)33-21)11-18-25-5-1-6-26-18/h1-3,5-6,8,12H,4,7,9-11H2
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289645
PNG
(6-(4-Chloro-2-fluorobenzyl)-9-((tetrahydrofuran-3-...)
Show SMILES Fc1cc(Cl)ccc1Cn1c2sc3CN(CC4CCOC4)CCc3c2c2ncnn2c1=O
Show InChI InChI=1S/C22H21ClFN5O2S/c23-15-2-1-14(17(24)7-15)9-28-21-19(20-25-12-26-29(20)22(28)30)16-3-5-27(10-18(16)32-21)8-13-4-6-31-11-13/h1-2,7,12-13H,3-6,8-11H2
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289646
PNG
(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-3-yl)m...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCCOC5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H27N5O3S/c1-31-18-6-4-16(5-7-18)12-28-23-21(22-25-15-26-29(22)24(28)30)19-8-9-27(13-20(19)33-23)11-17-3-2-10-32-14-17/h4-7,15,17H,2-3,8-14H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289647
PNG
(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOCC5)CC(F)(F)c4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H25F2N5O3S/c1-33-17-4-2-15(3-5-17)11-30-22-19(21-27-14-28-31(21)23(30)32)20-18(35-22)12-29(13-24(20,25)26)10-16-6-8-34-9-7-16/h2-5,14,16H,6-13H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289648
PNG
(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCCOC5)CC(F)(F)c4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H25F2N5O3S/c1-33-17-6-4-15(5-7-17)10-30-22-19(21-27-14-28-31(21)23(30)32)20-18(35-22)11-29(13-24(20,25)26)9-16-3-2-8-34-12-16/h4-7,14,16H,2-3,8-13H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289649
PNG
(6-(2-Fluoro-4-methoxybenzyl)-9-(pyrimidin-2-ylmeth...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5ncccn5)CCc4c3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C23H20FN7O2S/c1-33-15-4-3-14(17(24)9-15)10-30-22-20(21-27-13-28-31(21)23(30)32)16-5-8-29(11-18(16)34-22)12-19-25-6-2-7-26-19/h2-4,6-7,9,13H,5,8,10-12H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289650
PNG
(6-(2-Fluoro-4-methoxybenzyl)-9-((1-methyl-1H-imida...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5nccn5C)CCc4c3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C23H22FN7O2S/c1-28-8-6-25-19(28)12-29-7-5-16-18(11-29)34-22-20(16)21-26-13-27-31(21)23(32)30(22)10-14-3-4-15(33-2)9-17(14)24/h3-4,6,8-9,13H,5,7,10-12H2,1-2H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289651
PNG
(6-(2-Fluoro-4-methoxybenzyl)-9-(pyridin-2-ylmethyl...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5ccccn5)CCc4c3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C24H21FN6O2S/c1-33-17-6-5-15(19(25)10-17)11-30-23-21(22-27-14-28-31(22)24(30)32)18-7-9-29(13-20(18)34-23)12-16-4-2-3-8-26-16/h2-6,8,10,14H,7,9,11-13H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289652
PNG
(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydrofuran-3...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOC5)CCc4c3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C23H24FN5O3S/c1-31-16-3-2-15(18(24)8-16)10-28-22-20(21-25-13-26-29(21)23(28)30)17-4-6-27(11-19(17)33-22)9-14-5-7-32-12-14/h2-3,8,13-14H,4-7,9-12H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289653
PNG
(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOCC5)CCc4c3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C24H26FN5O3S/c1-32-17-3-2-16(19(25)10-17)12-29-23-21(22-26-14-27-30(22)24(29)31)18-4-7-28(13-20(18)34-23)11-15-5-8-33-9-6-15/h2-3,10,14-15H,4-9,11-13H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289654
PNG
(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCCOC5)CCc4c3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C24H26FN5O3S/c1-32-17-5-4-16(19(25)9-17)11-29-23-21(22-26-14-27-30(22)24(29)31)18-6-7-28(12-20(18)34-23)10-15-3-2-8-33-13-15/h4-5,9,14-15H,2-3,6-8,10-13H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289655
PNG
(6-(4-Methoxybenzyl)-9-((tetrahydrofuran-3-yl)methy...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOC5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H27N5O3S/c1-31-18-6-4-16(5-7-18)12-28-23-21(22-25-15-26-29(22)24(28)30)19-3-2-9-27(13-20(19)33-23)11-17-8-10-32-14-17/h4-7,15,17H,2-3,8-14H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289656
PNG
(6-(4-Methoxybenzyl)-9-((1-methyl-1H-imidazol-2-yl)...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5nccn5C)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H25N7O2S/c1-28-11-9-25-20(28)14-29-10-3-4-18-19(13-29)34-23-21(18)22-26-15-27-31(22)24(32)30(23)12-16-5-7-17(33-2)8-6-16/h5-9,11,15H,3-4,10,12-14H2,1-2H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289657
PNG
(6-(4-Methoxybenzyl)-9-(pyrimidin-2-ylmethyl)-6,8,9...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5ncccn5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H23N7O2S/c1-33-17-7-5-16(6-8-17)12-30-23-21(22-27-15-28-31(22)24(30)32)18-4-2-11-29(13-19(18)34-23)14-20-25-9-3-10-26-20/h3,5-10,15H,2,4,11-14H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289658
PNG
(6-(4-Methoxybenzyl)-9-(pyridin-2-ylmethyl)-6,8,9,1...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5ccccn5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C25H24N6O2S/c1-33-19-9-7-17(8-10-19)13-30-24-22(23-27-16-28-31(23)25(30)32)20-6-4-12-29(15-21(20)34-24)14-18-5-2-3-11-26-18/h2-3,5,7-11,16H,4,6,12-15H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289659
PNG
(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOCC5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C25H29N5O3S/c1-32-19-6-4-17(5-7-19)14-29-24-22(23-26-16-27-30(23)25(29)31)20-3-2-10-28(15-21(20)34-24)13-18-8-11-33-12-9-18/h4-7,16,18H,2-3,8-15H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289660
PNG
(6-(4-Methoxybenzyl)-8-((tetrahydro-2H-pyran-4-yl)m...)
Show SMILES COc1ccc(Cn2c3sc4N(CC5CCOCC5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H27N5O3S/c1-31-18-6-4-16(5-7-18)14-28-23-20(21-25-15-26-29(21)24(28)30)19-3-2-10-27(22(19)33-23)13-17-8-11-32-12-9-17/h4-7,15,17H,2-3,8-14H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289661
PNG
(6-(4-Methoxybenzyl)-8-((tetrahydro-2H-pyran-3-yl)m...)
Show SMILES COc1ccc(Cn2c3sc4N(CC5CCCOC5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H27N5O3S/c1-31-18-8-6-16(7-9-18)13-28-23-20(21-25-15-26-29(21)24(28)30)19-5-2-10-27(22(19)33-23)12-17-4-3-11-32-14-17/h6-9,15,17H,2-5,10-14H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289662
PNG
(6-(4-Methoxybenzyl)-8-((tetrahydrofuran-3-yl)methy...)
Show SMILES COc1ccc(Cn2c3sc4N(CC5CCOC5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H25N5O3S/c1-30-17-6-4-15(5-7-17)12-27-22-19(20-24-14-25-28(20)23(27)29)18-3-2-9-26(21(18)32-22)11-16-8-10-31-13-16/h4-7,14,16H,2-3,8-13H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289667
PNG
(11,11-Difluoro-6-(2-fluoro-4-methoxybenzyl)-9-((te...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOCC5)CC(F)(F)c4c3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C24H24F3N5O3S/c1-34-16-3-2-15(17(25)8-16)10-31-22-19(21-28-13-29-32(21)23(31)33)20-18(36-22)11-30(12-24(20,26)27)9-14-4-6-35-7-5-14/h2-3,8,13-14H,4-7,9-12H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289668
PNG
(6-(4-Chlorobenzyl)-9-(pyrazine-2-carbonyl)-8,9,10,...)
Show SMILES Clc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)c2cnccn2)cc1
Show InChI InChI=1S/C22H16ClN7O2S/c23-14-3-1-13(2-4-14)10-29-21-18(19-26-12-27-30(19)22(29)32)15-5-8-28(11-17(15)33-21)20(31)16-9-24-6-7-25-16/h1-4,6-7,9,12H,5,8,10-11H2
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289669
PNG
(6-(4-Chlorobenzyl)-9-(cyclopropanecarbonyl)-8,9,10...)
Show SMILES Clc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CC2)cc1
Show InChI InChI=1S/C21H18ClN5O2S/c22-14-5-1-12(2-6-14)9-26-20-17(18-23-11-24-27(18)21(26)29)15-7-8-25(10-16(15)30-20)19(28)13-3-4-13/h1-2,5-6,11,13H,3-4,7-10H2
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289670
PNG
(9-(Cyclopropanecarbonyl)-6-(4-methoxybenzyl)-8,9,1...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CC2)cc1
Show InChI InChI=1S/C22H21N5O3S/c1-30-15-6-2-13(3-7-15)10-26-21-18(19-23-12-24-27(19)22(26)29)16-8-9-25(11-17(16)31-21)20(28)14-4-5-14/h2-3,6-7,12,14H,4-5,8-11H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289671
PNG
(9-(2,2-Difluorocyclopropanecarbonyl)-6-(4-methoxyb...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CC2(F)F)cc1
Show InChI InChI=1S/C22H19F2N5O3S/c1-32-13-4-2-12(3-5-13)9-28-20-17(18-25-11-26-29(18)21(28)31)14-6-7-27(10-16(14)33-20)19(30)15-8-22(15,23)24/h2-5,11,15H,6-10H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289672
PNG
(6-(4-Methoxybenzyl)-9-(tetrahydrofuran-3-carbonyl)...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CCOC2)cc1
Show InChI InChI=1S/C23H23N5O4S/c1-31-16-4-2-14(3-5-16)10-27-22-19(20-24-13-25-28(20)23(27)30)17-6-8-26(11-18(17)33-22)21(29)15-7-9-32-12-15/h2-5,13,15H,6-12H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289673
PNG
(6-(4-Methoxybenzyl)-9-(methylsulfonyl)-8,9,10,11-t...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)S(C)(=O)=O)cc1
Show InChI InChI=1S/C19H19N5O4S2/c1-28-13-5-3-12(4-6-13)9-23-18-16(17-20-11-21-24(17)19(23)25)14-7-8-22(30(2,26)27)10-15(14)29-18/h3-6,11H,7-10H2,1-2H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289675
PNG
(6-(4-Chloro-2-fluorobenzyl)-9-(cyclopropanecarbony...)
Show SMILES Fc1cc(Cl)ccc1Cn1c2sc3CN(CCc3c2c2ncnn2c1=O)C(=O)C1CC1
Show InChI InChI=1S/C21H17ClFN5O2S/c22-13-4-3-12(15(23)7-13)8-27-20-17(18-24-10-25-28(18)21(27)30)14-5-6-26(9-16(14)31-20)19(29)11-1-2-11/h3-4,7,10-11H,1-2,5-6,8-9H2
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289676
PNG
(6-(4-Chloro-2-fluorobenzyl)-9-(tetrahydrofuran-3-c...)
Show SMILES Fc1cc(Cl)ccc1Cn1c2sc3CN(CCc3c2c2ncnn2c1=O)C(=O)C1CCOC1
Show InChI InChI=1S/C22H19ClFN5O3S/c23-14-2-1-12(16(24)7-14)8-28-21-18(19-25-11-26-29(19)22(28)31)15-3-5-27(9-17(15)33-21)20(30)13-4-6-32-10-13/h1-2,7,11,13H,3-6,8-10H2
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289677
PNG
(11,11-Difluoro-6-(4-methoxybenzyl)-9-(tetrahydrofu...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC(F)(F)c4c3c3ncnn3c2=O)C(=O)C2CCOC2)cc1
Show InChI InChI=1S/C23H21F2N5O4S/c1-33-15-4-2-13(3-5-15)8-29-21-17(19-26-12-27-30(19)22(29)32)18-16(35-21)9-28(11-23(18,24)25)20(31)14-6-7-34-10-14/h2-5,12,14H,6-11H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289678
PNG
(6-(2-Fluoro-4-methoxybenzyl)-9-(tetrahydrofuran-3-...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CCOC2)c(F)c1
Show InChI InChI=1S/C23H22FN5O4S/c1-32-15-3-2-13(17(24)8-15)9-28-22-19(20-25-12-26-29(20)23(28)31)16-4-6-27(10-18(16)34-22)21(30)14-5-7-33-11-14/h2-3,8,12,14H,4-7,9-11H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289679
PNG
(9-(Cyclopropanecarbonyl)-6-(2-fluoro-4-methoxybenz...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CC2)c(F)c1
Show InChI InChI=1S/C22H20FN5O3S/c1-31-14-5-4-13(16(23)8-14)9-27-21-18(19-24-11-25-28(19)22(27)30)15-6-7-26(10-17(15)32-21)20(29)12-2-3-12/h4-5,8,11-12H,2-3,6-7,9-10H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289680
PNG
((R)-6-(4-Methoxybenzyl)-9-(tetrahydrofuran-3-carbo...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)[C@@H]2CCOC2)cc1
Show InChI InChI=1S/C23H23N5O4S/c1-31-16-4-2-14(3-5-16)10-27-22-19(20-24-13-25-28(20)23(27)30)17-6-8-26(11-18(17)33-22)21(29)15-7-9-32-12-15/h2-5,13,15H,6-12H2,1H3/t15-/m1/s1
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289672
PNG
(6-(4-Methoxybenzyl)-9-(tetrahydrofuran-3-carbonyl)...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CCOC2)cc1
Show InChI InChI=1S/C23H23N5O4S/c1-31-16-4-2-14(3-5-16)10-27-22-19(20-24-13-25-28(20)23(27)30)17-6-8-26(11-18(17)33-22)21(29)15-7-9-32-12-15/h2-5,13,15H,6-12H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289672
PNG
(6-(4-Methoxybenzyl)-9-(tetrahydrofuran-3-carbonyl)...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CCOC2)cc1
Show InChI InChI=1S/C23H23N5O4S/c1-31-16-4-2-14(3-5-16)10-27-22-19(20-24-13-25-28(20)23(27)30)17-6-8-26(11-18(17)33-22)21(29)15-7-9-32-12-15/h2-5,13,15H,6-12H2,1H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289683
PNG
((R)-6-(4-Methoxybenzyl)-9-(tetrahydrofuran-3-carbo...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCCc4c3c3ncnn3c2=O)C(=O)[C@@H]2CCOC2)cc1
Show InChI InChI=1S/C24H25N5O4S/c1-32-17-6-4-15(5-7-17)11-28-23-20(21-25-14-26-29(21)24(28)31)18-3-2-9-27(12-19(18)34-23)22(30)16-8-10-33-13-16/h4-7,14,16H,2-3,8-13H2,1H3/t16-/m1/s1
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289684
PNG
(9-(Cyclopropanecarbonyl)-6-(4-methoxybenzyl)-6,8,9...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCCc4c3c3ncnn3c2=O)C(=O)C2CC2)cc1
Show InChI InChI=1S/C23H23N5O3S/c1-31-16-8-4-14(5-9-16)11-27-22-19(20-24-13-25-28(20)23(27)30)17-3-2-10-26(12-18(17)32-22)21(29)15-6-7-15/h4-5,8-9,13,15H,2-3,6-7,10-12H2,1H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289685
PNG
(8-(Cyclopropanecarbonyl)-6-(4-methoxybenzyl)-8,9,1...)
Show SMILES COc1ccc(Cn2c3sc4N(CCCc4c3c3ncnn3c2=O)C(=O)C2CC2)cc1
Show InChI InChI=1S/C22H21N5O3S/c1-30-15-8-4-13(5-9-15)11-26-21-17(18-23-12-24-27(18)22(26)29)16-3-2-10-25(20(16)31-21)19(28)14-6-7-14/h4-5,8-9,12,14H,2-3,6-7,10-11H2,1H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289686
PNG
(6-(4-Methoxybenzyl)-8-(tetrahydrofuran-3-carbonyl)...)
Show SMILES COc1ccc(Cn2c3sc4N(CCCc4c3c3ncnn3c2=O)C(=O)C2CCOC2)cc1
Show InChI InChI=1S/C23H23N5O4S/c1-31-16-6-4-14(5-7-16)11-27-22-18(19-24-13-25-28(19)23(27)30)17-3-2-9-26(21(17)33-22)20(29)15-8-10-32-12-15/h4-7,13,15H,2-3,8-12H2,1H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289690
PNG
(6-(4-Methoxybenzyl)-9-(pyridin-2-yl)-8,9,10,11-tet...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)c2ccccn2)cc1
Show InChI InChI=1S/C23H20N6O2S/c1-31-16-7-5-15(6-8-16)12-28-22-20(21-25-14-26-29(21)23(28)30)17-9-11-27(13-18(17)32-22)19-4-2-3-10-24-19/h2-8,10,14H,9,11-13H2,1H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289697
PNG
(8-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-6-(4-...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCN(CC4)c4ccccc4F)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C26H25FN6O2S/c1-35-19-8-6-18(7-9-19)15-32-25-21(24-28-17-29-33(24)26(32)34)14-20(36-25)16-30-10-12-31(13-11-30)23-5-3-2-4-22(23)27/h2-9,14,17H,10-13,15-16H2,1H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289698
PNG
(8-((4-(3-Fluorophenyl)piperazin-1-yl)methyl)-6-(4-...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCN(CC4)c4cccc(F)c4)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C26H25FN6O2S/c1-35-21-7-5-18(6-8-21)15-32-25-23(24-28-17-29-33(24)26(32)34)14-22(36-25)16-30-9-11-31(12-10-30)20-4-2-3-19(27)13-20/h2-8,13-14,17H,9-12,15-16H2,1H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289700
PNG
(6-(4-Methoxybenzyl)-9-((3-phenoxypyrrolidin-1-yl)m...)
Show SMILES COc1ccc(Cn2c3scc(CN4CCC(C4)Oc4ccccc4)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C26H25N5O3S/c1-33-20-9-7-18(8-10-20)13-30-25-23(24-27-17-28-31(24)26(30)32)19(16-35-25)14-29-12-11-22(15-29)34-21-5-3-2-4-6-21/h2-10,16-17,22H,11-15H2,1H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289702
PNG
(6-(4-Methoxybenzyl)-8-(4-morpholinopiperidin-1-yl)...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCC(CC4)N4CCOCC4)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C25H30N6O3S/c1-33-20-4-2-18(3-5-20)15-30-24-22(23-26-17-27-31(23)25(30)32)14-21(35-24)16-28-8-6-19(7-9-28)29-10-12-34-13-11-29/h2-5,14,17,19H,6-13,15-16H2,1H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289704
PNG
(8-((4-Acetyl-1,4-diazepan-1-yl)methyl)-6-(4-methox...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCCN(CC4)C(C)=O)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H26N6O3S/c1-16(30)27-9-3-8-26(10-11-27)14-19-12-20-21-24-15-25-29(21)23(31)28(22(20)33-19)13-17-4-6-18(32-2)7-5-17/h4-7,12,15H,3,8-11,13-14H2,1-2H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM289705
PNG
(8-((1,4-Oxazepan-4-yl)methyl)-6-(2,3-difluoro-4-me...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCCOCC4)cc3c3ncnn3c2=O)c(F)c1F
Show InChI InChI=1S/C21H21F2N5O3S/c1-30-16-4-3-13(17(22)18(16)23)10-27-20-15(19-24-12-25-28(19)21(27)29)9-14(32-20)11-26-5-2-7-31-8-6-26/h3-4,9,12H,2,5-8,10-11H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
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