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Compile Data Set for Download or QSAR

Found 973 hits Enz. Inhib. hit(s) with Target = 'Calcium/calmodulin-dependent protein kinase type II subunit delta'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292540
PNG
((S)-2-(3-(cyclopropanecarboxamido)azetidin-1-yl)-N...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(C1)NC(=O)C1CC1
Show InChI InChI=1S/C30H36N8O2S/c1-4-36(5-2)19(3)15-31-29(39)21-13-25(34-27(14-21)37-17-22(18-37)33-30(40)20-8-9-20)23-16-32-38-11-10-24(35-28(23)38)26-7-6-12-41-26/h6-7,10-14,16,19-20,22H,4-5,8-9,15,17-18H2,1-3H3,(H,31,39)(H,33,40)/t19-/m0/s1
PDB

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n/an/an/an/a 3.75n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292437
PNG
((2-(5-phenylpyrazolo[1,5-a]pyrimidin-3-yl)pyridin-...)
Show SMILES O=C(N1CCCC[C@@H]1[C@@H]1CCCN1)c1ccnc(c1)-c1cnn2ccc(nc12)-c1ccccc1
Show InChI InChI=1S/C27H28N6O/c34-27(32-15-5-4-10-25(32)23-9-6-13-28-23)20-11-14-29-24(17-20)21-18-30-33-16-12-22(31-26(21)33)19-7-2-1-3-8-19/h1-3,7-8,11-12,14,16-18,23,25,28H,4-6,9-10,13,15H2/t23-,25+/m0/s1
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n/an/an/an/a 6.81n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292538
PNG
((S)-N-(1-(4-((2-(diethylamino)propyl)carbamoyl)-6-...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(C1)NC(=O)c1ncco1
Show InChI InChI=1S/C30H33N9O3S/c1-4-37(5-2)19(3)15-32-28(40)20-13-24(22-16-33-39-10-8-23(36-27(22)39)25-7-6-12-43-25)35-26(14-20)38-17-21(18-38)34-29(41)30-31-9-11-42-30/h6-14,16,19,21H,4-5,15,17-18H2,1-3H3,(H,32,40)(H,34,41)/t19-/m0/s1
PDB

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n/an/an/an/a 7.80n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292395
PNG
(2-(5-phenylpyrazolo[1,5-a]pyrimidin-3-yl)-N-(2-(pr...)
Show SMILES CCCNC(CC)CNC(=O)c1ccnc(c1)-c1cnn2ccc(nc12)-c1ccccc1
Show InChI InChI=1S/C25H28N6O/c1-3-12-26-20(4-2)16-28-25(32)19-10-13-27-23(15-19)21-17-29-31-14-11-22(30-24(21)31)18-8-6-5-7-9-18/h5-11,13-15,17,20,26H,3-4,12,16H2,1-2H3,(H,28,32)
PDB

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n/an/an/an/a 8.15n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292441
PNG
((2-(5-phenylpyrazolo[1,5-a]pyrimidin-3-yl)pyridin-...)
Show SMILES O=C(N1CCCC11CCCNC1)c1ccnc(c1)-c1cnn2ccc(nc12)-c1ccccc1
Show InChI InChI=1S/C26H26N6O/c33-25(31-14-5-11-26(31)10-4-12-27-18-26)20-8-13-28-23(16-20)21-17-29-32-15-9-22(30-24(21)32)19-6-2-1-3-7-19/h1-3,6-9,13,15-17,27H,4-5,10-12,14,18H2
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n/an/an/an/a 8.20n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292675
PNG
((S)-N-(2-(diethylamino)propyl)-2-(1-methyl-1H-pyra...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)-c1cnn(C)c1
Show InChI InChI=1S/C27H30N8OS/c1-5-34(6-2)18(3)14-28-27(36)19-12-23(20-15-29-33(4)17-20)31-24(13-19)21-16-30-35-10-9-22(32-26(21)35)25-8-7-11-37-25/h7-13,15-18H,5-6,14H2,1-4H3,(H,28,36)/t18-/m0/s1
PDB

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n/an/an/an/a 8.24n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292571
PNG
((S)-N-(2-(diethylamino)propyl)-2-(3-methoxy-3-meth...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(C)(C1)OC
Show InChI InChI=1S/C28H35N7O2S/c1-6-33(7-2)19(3)15-29-27(36)20-13-23(31-25(14-20)34-17-28(4,18-34)37-5)21-16-30-35-11-10-22(32-26(21)35)24-9-8-12-38-24/h8-14,16,19H,6-7,15,17-18H2,1-5H3,(H,29,36)/t19-/m0/s1
PDB

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n/an/an/an/a 8.28n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292486
PNG
((S)-2-(3-cyanoazetidin-1-yl)-N-(2-(diethylamino)pr...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(C1)C#N
Show InChI InChI=1S/C27H30N8OS/c1-4-33(5-2)18(3)14-29-27(36)20-11-23(31-25(12-20)34-16-19(13-28)17-34)21-15-30-35-9-8-22(32-26(21)35)24-7-6-10-37-24/h6-12,15,18-19H,4-5,14,16-17H2,1-3H3,(H,29,36)/t18-/m0/s1
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n/an/an/an/a 9.07n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292676
PNG
((S)-N-(2-(diethylamino)propyl)-2-(3,5-dimethyl-1H-...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1c(C)n[nH]c1C)-c1cnn2ccc(nc12)-c1cccs1
Show InChI InChI=1S/C28H32N8OS/c1-6-35(7-2)17(3)15-29-28(37)20-13-23(31-24(14-20)26-18(4)33-34-19(26)5)21-16-30-36-11-10-22(32-27(21)36)25-9-8-12-38-25/h8-14,16-17H,6-7,15H2,1-5H3,(H,29,37)(H,33,34)/t17-/m0/s1
PDB

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n/an/an/an/a 9.37n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292487
PNG
((S)-N-(2-(diethylamino)propyl)-2-(3-ethoxyazetidin...)
Show SMILES CCOC1CN(C1)c1cc(cc(n1)-c1cnn2ccc(nc12)-c1cccs1)C(=O)NC[C@H](C)N(CC)CC
Show InChI InChI=1S/C28H35N7O2S/c1-5-33(6-2)19(4)15-29-28(36)20-13-24(31-26(14-20)34-17-21(18-34)37-7-3)22-16-30-35-11-10-23(32-27(22)35)25-9-8-12-38-25/h8-14,16,19,21H,5-7,15,17-18H2,1-4H3,(H,29,36)/t19-/m0/s1
PDB

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n/an/an/an/a 9.45n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292652
PNG
(N-((S)-2-(diethylamino)propyl)-2-((S)-2-(3-methyl-...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC[C@H]1c1nc(C)no1
Show InChI InChI=1S/C29H33N9O2S/c1-5-36(6-2)18(3)16-30-28(39)20-14-23(33-26(15-20)37-11-10-24(37)29-32-19(4)35-40-29)21-17-31-38-12-9-22(34-27(21)38)25-8-7-13-41-25/h7-9,12-15,17-18,24H,5-6,10-11,16H2,1-4H3,(H,30,39)/t18-,24-/m0/s1
PDB

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n/an/an/an/a 9.53n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292521
PNG
((S)-N-(2-(diethylamino)propyl)-2-((N-methylmethyl)...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N(C)S(C)(=O)=O
Show InChI InChI=1S/C25H31N7O3S2/c1-6-31(7-2)17(3)15-26-25(33)18-13-21(28-23(14-18)30(4)37(5,34)35)19-16-27-32-11-10-20(29-24(19)32)22-9-8-12-36-22/h8-14,16-17H,6-7,15H2,1-5H3,(H,26,33)/t17-/m0/s1
PDB

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n/an/an/an/a 9.60n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292529
PNG
((S)-N-(2-(diethylamino)propyl)-2-(3-ethylureido)-6...)
Show SMILES CCNC(=O)Nc1cc(cc(n1)-c1cnn2ccc(nc12)-c1cccs1)C(=O)NC[C@H](C)N(CC)CC
Show InChI InChI=1S/C26H32N8O2S/c1-5-27-26(36)32-23-14-18(25(35)28-15-17(4)33(6-2)7-3)13-21(30-23)19-16-29-34-11-10-20(31-24(19)34)22-9-8-12-37-22/h8-14,16-17H,5-7,15H2,1-4H3,(H,28,35)(H2,27,30,32,36)/t17-/m0/s1
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n/an/an/an/a 9.83n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292575
PNG
((S)-2-((1H-pyrazol-4-yl)amino)-N-(2-(diethylamino)...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(Nc2cn[nH]c2)nc(c1)-c1cnn2ccc(nc12)-c1cccs1
Show InChI InChI=1S/C26H29N9OS/c1-4-34(5-2)17(3)13-27-26(36)18-11-22(32-24(12-18)31-19-14-28-29-15-19)20-16-30-35-9-8-21(33-25(20)35)23-7-6-10-37-23/h6-12,14-17H,4-5,13H2,1-3H3,(H,27,36)(H,28,29)(H,31,32)/t17-/m0/s1
PDB

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n/an/an/an/a 9.87n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292707
PNG
(N-((S)-2-(diethylamino)propyl)-2-(5-(5-fluorothiop...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1ccc(F)s1)N1CC[C@H]1C(=O)NC
Show InChI InChI=1S/C28H33FN8O2S/c1-5-35(6-2)17(3)15-31-27(38)18-13-21(33-25(14-18)36-11-10-22(36)28(39)30-4)19-16-32-37-12-9-20(34-26(19)37)23-7-8-24(29)40-23/h7-9,12-14,16-17,22H,5-6,10-11,15H2,1-4H3,(H,30,39)(H,31,38)/t17-,22-/m0/s1
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n/an/an/an/a 10n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292446
PNG
((S)-2-amino-N-(2-(diethylamino)propyl)-6-(5-(thiop...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(N)nc(c1)-c1cnn2ccc(nc12)-c1cccs1
Show InChI InChI=1S/C23H27N7OS/c1-4-29(5-2)15(3)13-25-23(31)16-11-19(27-21(24)12-16)17-14-26-30-9-8-18(28-22(17)30)20-7-6-10-32-20/h6-12,14-15H,4-5,13H2,1-3H3,(H2,24,27)(H,25,31)/t15-/m0/s1
PDB

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n/an/an/an/a 10.5n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292623
PNG
(N-((S)-2-(diethylamino)propyl)-2-((S)-2-(dimethyl ...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC[C@H]1C(=O)N(C)C
Show InChI InChI=1S/C29H36N8O2S/c1-6-35(7-2)19(3)17-30-28(38)20-15-23(32-26(16-20)36-12-11-24(36)29(39)34(4)5)21-18-31-37-13-10-22(33-27(21)37)25-9-8-14-40-25/h8-10,13-16,18-19,24H,6-7,11-12,17H2,1-5H3,(H,30,38)/t19-,24-/m0/s1
PDB

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n/an/an/an/a 10.7n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292511
PNG
((S)-N-(2-(diethylamino)propyl)-2-(1,1-dioxidoisoth...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CCCS1(=O)=O
Show InChI InChI=1S/C26H31N7O3S2/c1-4-31(5-2)18(3)16-27-26(34)19-14-22(29-24(15-19)33-10-7-13-38(33,35)36)20-17-28-32-11-9-21(30-25(20)32)23-8-6-12-37-23/h6,8-9,11-12,14-15,17-18H,4-5,7,10,13,16H2,1-3H3,(H,27,34)/t18-/m0/s1
PDB

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n/an/an/an/a 11.2n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292392
PNG
(N-(2-aminopentyl)-2-(5-phenylpyrazolo[1,5-a]pyrimi...)
Show SMILES CCCC(N)CNC(=O)c1ccnc(c1)-c1cnn2ccc(nc12)-c1ccccc1
Show InChI InChI=1S/C23H24N6O/c1-2-6-18(24)14-26-23(30)17-9-11-25-21(13-17)19-15-27-29-12-10-20(28-22(19)29)16-7-4-3-5-8-16/h3-5,7-13,15,18H,2,6,14,24H2,1H3,(H,26,30)
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n/an/an/an/a 11.8n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292686
PNG
((S)-N-(2-(diethylamino)propyl)-2-(1-(oxetan-3-yl)-...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)-c1cnn(c1)C1COC1
Show InChI InChI=1S/C29H32N8O2S/c1-4-35(5-2)19(3)13-30-29(38)20-11-25(21-14-31-37(16-21)22-17-39-18-22)33-26(12-20)23-15-32-36-9-8-24(34-28(23)36)27-7-6-10-40-27/h6-12,14-16,19,22H,4-5,13,17-18H2,1-3H3,(H,30,38)/t19-/m0/s1
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n/an/an/an/a 12.3n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292685
PNG
((S)-2-(1-(2-cyanoethyl)-1H-pyrazol-4-yl)-N-(2-(die...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)-c1cnn(CCC#N)c1
Show InChI InChI=1S/C29H31N9OS/c1-4-36(5-2)20(3)16-31-29(39)21-14-25(22-17-32-37(19-22)11-7-10-30)34-26(15-21)23-18-33-38-12-9-24(35-28(23)38)27-8-6-13-40-27/h6,8-9,12-15,17-20H,4-5,7,11,16H2,1-3H3,(H,31,39)/t20-/m0/s1
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n/an/an/an/a 12.8n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292684
PNG
((S)-N-(2-(diethylamino)propyl)-2-(1H-pyrazol-4-yl)...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)-c1cn[nH]c1
Show InChI InChI=1S/C26H28N8OS/c1-4-33(5-2)17(3)13-27-26(35)18-11-22(19-14-28-29-15-19)31-23(12-18)20-16-30-34-9-8-21(32-25(20)34)24-7-6-10-36-24/h6-12,14-17H,4-5,13H2,1-3H3,(H,27,35)(H,28,29)/t17-/m0/s1
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n/an/an/an/a 13.5n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292703
PNG
(N-((S)-2-(ethyl(propyl)amino)propyl)-2-((S)-2-(met...)
Show SMILES CCCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC[C@H]1C(=O)NC
Show InChI InChI=1S/C29H36N8O2S/c1-5-11-35(6-2)19(3)17-31-28(38)20-15-23(33-26(16-20)36-12-10-24(36)29(39)30-4)21-18-32-37-13-9-22(34-27(21)37)25-8-7-14-40-25/h7-9,13-16,18-19,24H,5-6,10-12,17H2,1-4H3,(H,30,39)(H,31,38)/t19-,24-/m0/s1
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n/an/an/an/a 13.6n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292485
PNG
((S)-N-(2-(diethylamino)propyl)-2-(3-methoxyazetidi...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(C1)OC
Show InChI InChI=1S/C27H33N7O2S/c1-5-32(6-2)18(3)14-28-27(35)19-12-23(30-25(13-19)33-16-20(17-33)36-4)21-15-29-34-10-9-22(31-26(21)34)24-8-7-11-37-24/h7-13,15,18,20H,5-6,14,16-17H2,1-4H3,(H,28,35)/t18-/m0/s1
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n/an/an/an/a 13.7n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292468
PNG
((S)-2-chloro-N-(2-(ethylamino)propyl)-6-(5-phenylp...)
Show SMILES CCN[C@@H](C)CNC(=O)c1cc(Cl)nc(c1)-c1cnn2ccc(nc12)-c1ccccc1
Show InChI InChI=1S/C23H23ClN6O/c1-3-25-15(2)13-26-23(31)17-11-20(28-21(24)12-17)18-14-27-30-10-9-19(29-22(18)30)16-7-5-4-6-8-16/h4-12,14-15,25H,3,13H2,1-2H3,(H,26,31)/t15-/m0/s1
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n/an/an/an/a 13.8n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292520
PNG
((S)-N-(2-(diethylamino)propyl)-2-(5-(isothiazol-5-...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1ccns1)N1CC(C1)OC
Show InChI InChI=1S/C26H32N8O2S/c1-5-32(6-2)17(3)13-27-26(35)18-11-22(30-24(12-18)33-15-19(16-33)36-4)20-14-28-34-10-8-21(31-25(20)34)23-7-9-29-37-23/h7-12,14,17,19H,5-6,13,15-16H2,1-4H3,(H,27,35)/t17-/m0/s1
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n/an/an/an/a 13.9n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292456
PNG
((S)-N-(2-(diethylamino)propyl)-2-methoxy-6-(5-(thi...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(OC)nc(c1)-c1cnn2ccc(nc12)-c1cccs1
Show InChI InChI=1S/C24H28N6O2S/c1-5-29(6-2)16(3)14-25-24(31)17-12-20(27-22(13-17)32-4)18-15-26-30-10-9-19(28-23(18)30)21-8-7-11-33-21/h7-13,15-16H,5-6,14H2,1-4H3,(H,25,31)/t16-/m0/s1
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n/an/an/an/a 13.9n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292430
PNG
(((4aR,8R,8aS)-8-aminooctahydroquinolin-1(2H)-yl)(2...)
Show SMILES N[C@@H]1CCC[C@@H]2CCCN([C@H]12)C(=O)c1ccnc(c1)-c1cnn2ccc(nc12)-c1cccs1
Show InChI InChI=1S/C25H26N6OS/c26-19-6-1-4-16-5-2-11-30(23(16)19)25(32)17-8-10-27-21(14-17)18-15-28-31-12-9-20(29-24(18)31)22-7-3-13-33-22/h3,7-10,12-16,19,23H,1-2,4-6,11,26H2/t16-,19-,23+/m1/s1
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n/an/an/an/a 14.1n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292680
PNG
((S)-N-(2-(diethylamino)propyl)-2-(1H-pyrazol-3-yl)...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)-c1cc[nH]n1
Show InChI InChI=1S/C26H28N8OS/c1-4-33(5-2)17(3)15-27-26(35)18-13-22(30-23(14-18)20-8-10-28-32-20)19-16-29-34-11-9-21(31-25(19)34)24-7-6-12-36-24/h6-14,16-17H,4-5,15H2,1-3H3,(H,27,35)(H,28,32)/t17-/m0/s1
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n/an/an/an/a 14.5n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292509
PNG
((S)-N-(2-(diethylamino)propyl)-2-(3-methoxyazetidi...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1ccsc1)N1CC(C1)OC
Show InChI InChI=1S/C27H33N7O2S/c1-5-32(6-2)18(3)13-28-27(35)20-11-24(30-25(12-20)33-15-21(16-33)36-4)22-14-29-34-9-7-23(31-26(22)34)19-8-10-37-17-19/h7-12,14,17-18,21H,5-6,13,15-16H2,1-4H3,(H,28,35)/t18-/m0/s1
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n/an/an/an/a 14.9n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292370
PNG
((S)-N-(2-((cyclopropylmethyl)amino)propyl)-2-(5-(t...)
Show SMILES C[C@@H](CNC(=O)c1ccnc(c1)-c1cnn2ccc(nc12)-c1cccs1)NCC1CC1
Show InChI InChI=1S/C23H24N6OS/c1-15(25-13-16-4-5-16)12-26-23(30)17-6-8-24-20(11-17)18-14-27-29-9-7-19(28-22(18)29)21-3-2-10-31-21/h2-3,6-11,14-16,25H,4-5,12-13H2,1H3,(H,26,30)/t15-/m0/s1
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n/an/an/an/a 15.1n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292467
PNG
((S)-2-cyclopropyl-N-(2-(ethylamino)propyl)-6-(5-ph...)
Show SMILES CCN[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1ccccc1)C1CC1
Show InChI InChI=1S/C26H28N6O/c1-3-27-17(2)15-28-26(33)20-13-23(19-9-10-19)30-24(14-20)21-16-29-32-12-11-22(31-25(21)32)18-7-5-4-6-8-18/h4-8,11-14,16-17,19,27H,3,9-10,15H2,1-2H3,(H,28,33)/t17-/m0/s1
PDB

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n/an/an/an/a 15.3n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292628
PNG
(N-((S)-2-(diethylamino)propyl)-2-((S)-2-(3-fluoroa...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC[C@H]1C(=O)N1CC(F)C1
Show InChI InChI=1S/C30H35FN8O2S/c1-4-36(5-2)19(3)15-32-29(40)20-13-24(22-16-33-39-11-8-23(35-28(22)39)26-7-6-12-42-26)34-27(14-20)38-10-9-25(38)30(41)37-17-21(31)18-37/h6-8,11-14,16,19,21,25H,4-5,9-10,15,17-18H2,1-3H3,(H,32,40)/t19-,25-/m0/s1
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n/an/an/an/a 16.2n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292504
PNG
((S)-N-(2-(diethylamino)propyl)-2-(3-methoxyazetidi...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1ccccc1)N1CC(C1)OC
Show InChI InChI=1S/C29H35N7O2/c1-5-34(6-2)20(3)16-30-29(37)22-14-26(32-27(15-22)35-18-23(19-35)38-4)24-17-31-36-13-12-25(33-28(24)36)21-10-8-7-9-11-21/h7-15,17,20,23H,5-6,16,18-19H2,1-4H3,(H,30,37)/t20-/m0/s1
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n/an/an/an/a 16.9n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292345
PNG
(N-(2-(diethylamino)ethyl)-2-(5-(thiophen-2-yl)pyra...)
Show SMILES CCN(CC)CCNC(=O)c1ccnc(c1)-c1cnn2ccc(nc12)-c1cccs1
Show InChI InChI=1S/C22H24N6OS/c1-3-27(4-2)12-10-24-22(29)16-7-9-23-19(14-16)17-15-25-28-11-8-18(26-21(17)28)20-6-5-13-30-20/h5-9,11,13-15H,3-4,10,12H2,1-2H3,(H,24,29)
PDB

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n/an/an/an/a 17.1n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292492
PNG
((S)-N-(2-(diethylamino)propyl)-2-(3,3-difluoroazet...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(F)(F)C1
Show InChI InChI=1S/C26H29F2N7OS/c1-4-33(5-2)17(3)13-29-25(36)18-11-21(31-23(12-18)34-15-26(27,28)16-34)19-14-30-35-9-8-20(32-24(19)35)22-7-6-10-37-22/h6-12,14,17H,4-5,13,15-16H2,1-3H3,(H,29,36)/t17-/m0/s1
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n/an/an/an/a 17.3n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292489
PNG
((S)-N-(2-(diethylamino)propyl)-2-(3-hydroxyazetidi...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(O)C1
Show InChI InChI=1S/C26H31N7O2S/c1-4-31(5-2)17(3)13-27-26(35)18-11-22(29-24(12-18)32-15-19(34)16-32)20-14-28-33-9-8-21(30-25(20)33)23-7-6-10-36-23/h6-12,14,17,19,34H,4-5,13,15-16H2,1-3H3,(H,27,35)/t17-/m0/s1
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n/an/an/an/a 17.7n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292709
PNG
((S)-N-(2-(diethylamino)propyl)-4-(5-(thiophen-2-yl...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(ccn1)-c1cnn2ccc(nc12)-c1cccs1
Show InChI InChI=1S/C23H26N6OS/c1-4-28(5-2)16(3)14-25-23(30)20-13-17(8-10-24-20)18-15-26-29-11-9-19(27-22(18)29)21-7-6-12-31-21/h6-13,15-16H,4-5,14H2,1-3H3,(H,25,30)/t16-/m0/s1
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n/an/an/an/a 18n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292577
PNG
((S)-N-(2-(diethylamino)propyl)-2-(2-oxa-6-azaspiro...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CCC2(COC2)C1
Show InChI InChI=1S/C29H35N7O2S/c1-4-34(5-2)20(3)15-30-28(37)21-13-24(32-26(14-21)35-11-9-29(17-35)18-38-19-29)22-16-31-36-10-8-23(33-27(22)36)25-7-6-12-39-25/h6-8,10,12-14,16,20H,4-5,9,11,15,17-19H2,1-3H3,(H,30,37)/t20-/m0/s1
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n/an/an/an/a 18.2n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292466
PNG
((S)-N-(2-(ethylamino)propyl)-2-isopropyl-6-(5-phen...)
Show SMILES CCN[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1ccccc1)C(C)C
Show InChI InChI=1S/C26H30N6O/c1-5-27-18(4)15-28-26(33)20-13-23(17(2)3)30-24(14-20)21-16-29-32-12-11-22(31-25(21)32)19-9-7-6-8-10-19/h6-14,16-18,27H,5,15H2,1-4H3,(H,28,33)/t18-/m0/s1
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n/an/an/an/a 19.5n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292488
PNG
((S)-N-(2-(diethylamino)propyl)-2-(3-(difluorometho...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(C1)OC(F)F
Show InChI InChI=1S/C27H31F2N7O2S/c1-4-34(5-2)17(3)13-30-26(37)18-11-22(32-24(12-18)35-15-19(16-35)38-27(28)29)20-14-31-36-9-8-21(33-25(20)36)23-7-6-10-39-23/h6-12,14,17,19,27H,4-5,13,15-16H2,1-3H3,(H,30,37)/t17-/m0/s1
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n/an/an/an/a 19.9n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292678
PNG
((S)-N-(2-(diethylamino)propyl)-2-(5-(thiophen-2-yl...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)-c1c[nH]nc1C(F)(F)F
Show InChI InChI=1S/C27H27F3N8OS/c1-4-37(5-2)16(3)13-31-26(39)17-11-21(18-14-32-36-24(18)27(28,29)30)34-22(12-17)19-15-33-38-9-8-20(35-25(19)38)23-7-6-10-40-23/h6-12,14-16H,4-5,13H2,1-3H3,(H,31,39)(H,32,36)/t16-/m0/s1
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n/an/an/an/a 20.3n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292533
PNG
((S)-N-(2-(diethylamino)propyl)-2-isobutyramido-6-(...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(NC(=O)C(C)C)nc(c1)-c1cnn2ccc(nc12)-c1cccs1
Show InChI InChI=1S/C27H33N7O2S/c1-6-33(7-2)18(5)15-28-27(36)19-13-22(30-24(14-19)32-26(35)17(3)4)20-16-29-34-11-10-21(31-25(20)34)23-9-8-12-37-23/h8-14,16-18H,6-7,15H2,1-5H3,(H,28,36)(H,30,32,35)/t18-/m0/s1
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n/an/an/an/a 20.5n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292497
PNG
((S)-N-(2-(diethylamino)propyl)-2-(3-fluoroazetidin...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(F)C1
Show InChI InChI=1S/C26H30FN7OS/c1-4-32(5-2)17(3)13-28-26(35)18-11-22(30-24(12-18)33-15-19(27)16-33)20-14-29-34-9-8-21(31-25(20)34)23-7-6-10-36-23/h6-12,14,17,19H,4-5,13,15-16H2,1-3H3,(H,28,35)/t17-/m0/s1
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n/an/an/an/a 20.5n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292572
PNG
((S)-N-(2-(diethylamino)propyl)-2-(methylamino)-6-(...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(NC)nc(c1)-c1cnn2ccc(nc12)-c1cccs1
Show InChI InChI=1S/C24H29N7OS/c1-5-30(6-2)16(3)14-26-24(32)17-12-20(28-22(13-17)25-4)18-15-27-31-10-9-19(29-23(18)31)21-8-7-11-33-21/h7-13,15-16H,5-6,14H2,1-4H3,(H,25,28)(H,26,32)/t16-/m0/s1
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n/an/an/an/a 21.1n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292637
PNG
(N-((S)-2-(diethylamino)propyl)-2-((S)-2-(morpholin...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC[C@H]1C(=O)N1CCOCC1
Show InChI InChI=1S/C31H38N8O3S/c1-4-36(5-2)21(3)19-32-30(40)22-17-25(23-20-33-39-11-8-24(35-29(23)39)27-7-6-16-43-27)34-28(18-22)38-10-9-26(38)31(41)37-12-14-42-15-13-37/h6-8,11,16-18,20-21,26H,4-5,9-10,12-15,19H2,1-3H3,(H,32,40)/t21-,26-/m0/s1
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n/an/an/an/a 21.3n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292348
PNG
((S)-N-(2-(diethylamino)propyl)-2-(5-(thiophen-2-yl...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1ccnc(c1)-c1cnn2ccc(nc12)-c1cccs1
Show InChI InChI=1S/C23H26N6OS/c1-4-28(5-2)16(3)14-25-23(30)17-8-10-24-20(13-17)18-15-26-29-11-9-19(27-22(18)29)21-7-6-12-31-21/h6-13,15-16H,4-5,14H2,1-3H3,(H,25,30)/t16-/m0/s1
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n/an/an/an/a 21.4n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292570
PNG
((S)-N-(2-(diethylamino)propyl)-2-(3-hydroxy-3-meth...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(C)(O)C1
Show InChI InChI=1S/C27H33N7O2S/c1-5-32(6-2)18(3)14-28-26(35)19-12-22(30-24(13-19)33-16-27(4,36)17-33)20-15-29-34-10-9-21(31-25(20)34)23-8-7-11-37-23/h7-13,15,18,36H,5-6,14,16-17H2,1-4H3,(H,28,35)/t18-/m0/s1
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n/an/an/an/a 21.4n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292560
PNG
((S)-N-(2-(diethylamino)propyl)-2-(3-(hydroxymethyl...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(CO)C1
Show InChI InChI=1S/C27H33N7O2S/c1-4-32(5-2)18(3)13-28-27(36)20-11-23(30-25(12-20)33-15-19(16-33)17-35)21-14-29-34-9-8-22(31-26(21)34)24-7-6-10-37-24/h6-12,14,18-19,35H,4-5,13,15-17H2,1-3H3,(H,28,36)/t18-/m0/s1
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n/an/an/an/a 21.6n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292483
PNG
((R)-(2-(aminomethyl)piperidin-1-yl)(5-(methylamino...)
Show SMILES CNc1cnc(cc1C(=O)N1CCCC[C@@H]1CN)-c1cnn2ccc(nc12)-c1ccccc1
Show InChI InChI=1S/C25H27N7O/c1-27-23-16-28-22(13-19(23)25(33)31-11-6-5-9-18(31)14-26)20-15-29-32-12-10-21(30-24(20)32)17-7-3-2-4-8-17/h2-4,7-8,10,12-13,15-16,18,27H,5-6,9,11,14,26H2,1H3/t18-/m1/s1
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n/an/an/an/a 21.8n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)

More data for this
Ligand-Target Pair
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