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Compile Data Set for Download or QSAR

Found 82 hits Enz. Inhib. hit(s) with Target = 'Calcium-activated potassium channel alpha/beta 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50426567
PNG
(BMS-204352 | FLINDOKALNER | MaxiPost)
Show SMILES COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
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n/an/an/an/a 352n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive modulation of Kca 1.1 (unknown origin)


J Med Chem 56: 593-624 (2013)


Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50128974
PNG
(2-Azepan-1-yl-1H-pyrrolo[3,2-b]pyridine-3-carbonit...)
Show SMILES N#Cc1c([nH]c2cccnc12)N1CCCCCC1
Show InChI InChI=1S/C14H16N4/c15-10-11-13-12(6-5-7-16-13)17-14(11)18-8-3-1-2-4-9-18/h5-7,17H,1-4,8-9H2
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n/an/an/an/a 3.34E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
[86Rb+] efflux induced by BKca alpha subunits expressed in HEK293 cells at 10 microM


Bioorg Med Chem Lett 13: 2003-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00324-x
BindingDB Entry DOI: 10.7270/Q2QN6647
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50128985
PNG
(2-Morpholin-4-yl-1H-pyrrolo[3,2-b]pyridine-3-carbo...)
Show SMILES N#Cc1c([nH]c2cccnc12)N1CCOCC1
Show InChI InChI=1S/C12H12N4O/c13-8-9-11-10(2-1-3-14-11)15-12(9)16-4-6-17-7-5-16/h1-3,15H,4-7H2
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n/an/an/an/a 3.86E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
[86Rb+] efflux induced by BKca alpha subunits expressed in HEK293 cells at 10 microM


Bioorg Med Chem Lett 13: 2003-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00324-x
BindingDB Entry DOI: 10.7270/Q2QN6647
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50128979
PNG
(2-(3-Aza-bicyclo[3.2.2]non-3-yl)-1H-pyrrolo[3,2-b]...)
Show SMILES N#Cc1c([nH]c2cccnc12)N1CC2CCC(CC2)C1
Show InChI InChI=1S/C16H18N4/c17-8-13-15-14(2-1-7-18-15)19-16(13)20-9-11-3-4-12(10-20)6-5-11/h1-2,7,11-12,19H,3-6,9-10H2
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n/an/an/an/a 4.43E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
[86Rb+] efflux induced by BKca alpha subunits expressed in HEK293 cells at 10 microM


Bioorg Med Chem Lett 13: 2003-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00324-x
BindingDB Entry DOI: 10.7270/Q2QN6647
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50128975
PNG
(2-((S)-3-Hydroxy-piperidin-1-yl)-1H-pyrrolo[3,2-b]...)
Show SMILES O[C@H]1CCCN(C1)c1[nH]c2cccnc2c1C#N
Show InChI InChI=1S/C13H14N4O/c14-7-10-12-11(4-1-5-15-12)16-13(10)17-6-2-3-9(18)8-17/h1,4-5,9,16,18H,2-3,6,8H2/t9-/m0/s1
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n/an/an/an/a 5.07E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
[86Rb+] efflux induced by BKca alpha subunits expressed in HEK293 cells at 10 microM


Bioorg Med Chem Lett 13: 2003-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00324-x
BindingDB Entry DOI: 10.7270/Q2QN6647
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50128973
PNG
(2-Dimethylamino-1H-pyrrolo[3,2-b]pyridine-3-carbon...)
Show SMILES CN(C)c1[nH]c2cccnc2c1C#N
Show InChI InChI=1S/C10H10N4/c1-14(2)10-7(6-11)9-8(13-10)4-3-5-12-9/h3-5,13H,1-2H3
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n/an/an/an/a 5.13E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
[86Rb+] efflux induced by BKca alpha subunits expressed in HEK293 cells at 10 microM


Bioorg Med Chem Lett 13: 2003-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00324-x
BindingDB Entry DOI: 10.7270/Q2QN6647
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50128978
PNG
(2-Imidazol-1-yl-1H-pyrrolo[3,2-b]pyridine-3-carbon...)
Show SMILES N#Cc1c([nH]c2cccnc12)-n1ccnc1
Show InChI InChI=1S/C11H7N5/c12-6-8-10-9(2-1-3-14-10)15-11(8)16-5-4-13-7-16/h1-5,7,15H
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n/an/an/an/a 5.86E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
[86Rb+] efflux induced by BKca alpha subunits expressed in HEK293 cells at 10 microM


Bioorg Med Chem Lett 13: 2003-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00324-x
BindingDB Entry DOI: 10.7270/Q2QN6647
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50128984
PNG
(2-[(2-Dimethylamino-ethyl)-methyl-amino]-1H-pyrrol...)
Show SMILES CN(C)CCN(C)c1[nH]c2cccnc2c1C#N
Show InChI InChI=1S/C13H17N5/c1-17(2)7-8-18(3)13-10(9-14)12-11(16-13)5-4-6-15-12/h4-6,16H,7-8H2,1-3H3
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n/an/an/an/a 6.75E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
[86Rb+] efflux induced by BKca alpha subunits expressed in HEK293 cells at 10 microM


Bioorg Med Chem Lett 13: 2003-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00324-x
BindingDB Entry DOI: 10.7270/Q2QN6647
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50128982
PNG
(2-Diethylamino-1H-pyrrolo[3,2-b]pyridine-3-carboni...)
Show SMILES CCN(CC)c1[nH]c2cccnc2c1C#N
Show InChI InChI=1S/C12H14N4/c1-3-16(4-2)12-9(8-13)11-10(15-12)6-5-7-14-11/h5-7,15H,3-4H2,1-2H3
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n/an/an/an/a 6.94E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
[86Rb+] efflux induced by BKca alpha subunits expressed in HEK293 cells at 10 microM


Bioorg Med Chem Lett 13: 2003-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00324-x
BindingDB Entry DOI: 10.7270/Q2QN6647
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50128980
PNG
(2-Pyrrolidin-1-yl-1H-pyrrolo[3,2-b]pyridine-3-carb...)
Show SMILES N#Cc1c([nH]c2cccnc12)N1CCCC1
Show InChI InChI=1S/C12H12N4/c13-8-9-11-10(4-3-5-14-11)15-12(9)16-6-1-2-7-16/h3-5,15H,1-2,6-7H2
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n/an/an/an/a 8.12E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
[86Rb+] efflux induced by BKca alpha subunits expressed in HEK293 cells at 10 microM


Bioorg Med Chem Lett 13: 2003-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00324-x
BindingDB Entry DOI: 10.7270/Q2QN6647
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50128977
PNG
(2-Hydroxy-1H-pyrrolo[3,2-b]pyridine-3-carbonitrile...)
Show SMILES O=c1[nH]c2ccc[nH]c2c1C#N
Show InChI InChI=1S/C8H5N3O/c9-4-5-7-6(11-8(5)12)2-1-3-10-7/h1-3,10H,(H,11,12)
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n/an/an/an/a 1.34E+4n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
[86Rb+] efflux induced by BKca alpha subunits expressed in HEK293 cells at 10 microM


Bioorg Med Chem Lett 13: 2003-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00324-x
BindingDB Entry DOI: 10.7270/Q2QN6647
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50128976
PNG
(2-(4-Hydroxy-piperidin-1-yl)-1H-pyrrolo[3,2-b]pyri...)
Show SMILES OC1CCN(CC1)c1[nH]c2cccnc2c1C#N
Show InChI InChI=1S/C13H14N4O/c14-8-10-12-11(2-1-5-15-12)16-13(10)17-6-3-9(18)4-7-17/h1-2,5,9,16,18H,3-4,6-7H2
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n/an/an/an/a 1.51E+4n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
[86Rb+] efflux induced by BKca alpha subunits expressed in HEK293 cells at 10 microM


Bioorg Med Chem Lett 13: 2003-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00324-x
BindingDB Entry DOI: 10.7270/Q2QN6647
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50128981
PNG
(1-(3-Cyano-1H-pyrrolo[3,2-b]pyridin-2-yl)-piperidi...)
Show SMILES COC(=O)C1CCN(CC1)c1[nH]c2cccnc2c1C#N
Show InChI InChI=1S/C15H16N4O2/c1-21-15(20)10-4-7-19(8-5-10)14-11(9-16)13-12(18-14)3-2-6-17-13/h2-3,6,10,18H,4-5,7-8H2,1H3
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n/an/an/an/a 1.70E+4n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
[86Rb+] efflux induced by BKca alpha subunits expressed in HEK293 cells at 10 microM


Bioorg Med Chem Lett 13: 2003-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00324-x
BindingDB Entry DOI: 10.7270/Q2QN6647
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412618
PNG
(CHEMBL466000)
Show SMILES NC(=O)c1[nH]nnc1-n1nnc2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C10H6F3N7O/c11-10(12,13)4-1-2-6-5(3-4)15-19-20(6)9-7(8(14)21)16-18-17-9/h1-3H,(H2,14,21)(H,16,17,18)
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n/an/a 3.72E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412619
PNG
(CHEMBL466204)
Show SMILES NC(=O)c1[nH]nnc1-n1nnc2cc(Cl)ccc12
Show InChI InChI=1S/C9H6ClN7O/c10-4-1-2-6-5(3-4)12-16-17(6)9-7(8(11)18)13-15-14-9/h1-3H,(H2,11,18)(H,13,14,15)
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n/an/a 5.50E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412620
PNG
(CHEMBL468707)
Show SMILES NC(=O)c1[nH]nnc1-n1c2ccc(cc2[nH]c1=O)-c1ccccc1
Show InChI InChI=1S/C16H12N6O2/c17-14(23)13-15(20-21-19-13)22-12-7-6-10(8-11(12)18-16(22)24)9-4-2-1-3-5-9/h1-8H,(H2,17,23)(H,18,24)(H,19,20,21)
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n/an/a 5.50E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412621
PNG
(CHEMBL446913)
Show SMILES NC(=O)c1[nH]nnc1NC(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C11H9F3N6O2/c12-11(13,14)5-2-1-3-6(4-5)16-10(22)17-9-7(8(15)21)18-20-19-9/h1-4H,(H2,15,21)(H3,16,17,18,19,20,22)
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n/an/a 7.94E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412622
PNG
(CHEMBL449320)
Show SMILES NC(=O)c1[nH]nnc1-n1nnc2cc(F)ccc12
Show InChI InChI=1S/C9H6FN7O/c10-4-1-2-6-5(3-4)12-16-17(6)9-7(8(11)18)13-15-14-9/h1-3H,(H2,11,18)(H,13,14,15)
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n/an/a 9.33E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412623
PNG
(CHEMBL468913)
Show SMILES Cc1ccc2n(-c3nn[nH]c3C(N)=O)c(=O)[nH]c2c1
Show InChI InChI=1S/C11H10N6O2/c1-5-2-3-7-6(4-5)13-11(19)17(7)10-8(9(12)18)14-16-15-10/h2-4H,1H3,(H2,12,18)(H,13,19)(H,14,15,16)
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n/an/a 9.33E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412624
PNG
(CHEMBL503117)
Show SMILES NC(=O)c1[nH]nnc1Nc1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C9H8N6O3/c10-8(16)7-9(13-14-12-7)11-5-3-1-2-4-6(5)15(17)18/h1-4H,(H2,10,16)(H2,11,12,13,14)
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n/an/a 1.05E+5n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412625
PNG
(CHEMBL505582)
Show SMILES NC(=O)c1[nH]nnc1-n1nnc2ccccc12
Show InChI InChI=1S/C9H7N7O/c10-8(17)7-9(13-14-12-7)16-6-4-2-1-3-5(6)11-15-16/h1-4H,(H2,10,17)(H,12,13,14)
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n/an/a 1.12E+5n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412626
PNG
(CHEMBL499448)
Show SMILES COc1ccc2n(nnc2c1)-c1nn[nH]c1C(N)=O
Show InChI InChI=1S/C10H9N7O2/c1-19-5-2-3-7-6(4-5)12-16-17(7)10-8(9(11)18)13-15-14-10/h2-4H,1H3,(H2,11,18)(H,13,14,15)
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n/an/a 1.55E+5n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412627
PNG
(CHEMBL445346)
Show SMILES COc1ccc(Cl)cc1C(=O)Nc1cc(Cl)ccc1O
Show InChI InChI=1S/C14H11Cl2NO3/c1-20-13-5-3-8(15)6-10(13)14(19)17-11-7-9(16)2-4-12(11)18/h2-7,18H,1H3,(H,17,19)
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n/an/a 3.24n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412628
PNG
(CHEMBL448335)
Show SMILES COc1ccc(Cl)cc1C(=O)Nc1cc(C)ccc1O
Show InChI InChI=1S/C15H14ClNO3/c1-9-3-5-13(18)12(7-9)17-15(19)11-8-10(16)4-6-14(11)20-2/h3-8,18H,1-2H3,(H,17,19)
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n/an/a 27.5n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412629
PNG
(CHEMBL465922)
Show SMILES Oc1ccccc1Cn1cc(Cc2ccccc2)nn1
Show InChI InChI=1S/C16H15N3O/c20-16-9-5-4-8-14(16)11-19-12-15(17-18-19)10-13-6-2-1-3-7-13/h1-9,12,20H,10-11H2
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n/an/a 27.5n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412630
PNG
(CHEMBL524902)
Show SMILES Oc1ccc(Cl)cc1NC(=O)c1ccccc1O
Show InChI InChI=1S/C13H10ClNO3/c14-8-5-6-12(17)10(7-8)15-13(18)9-3-1-2-4-11(9)16/h1-7,16-17H,(H,15,18)
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n/an/a 135n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412631
PNG
(CHEMBL504160)
Show SMILES Cc1ccc2n(nnc2c1)C(=O)c1ccccc1O
Show InChI InChI=1S/C14H11N3O2/c1-9-6-7-12-11(8-9)15-16-17(12)14(19)10-4-2-3-5-13(10)18/h2-8,18H,1H3
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n/an/a 145n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412632
PNG
(CHEMBL511200)
Show SMILES Oc1ccc(Cl)cc1-n1cc(Cc2ccccc2)nn1
Show InChI InChI=1S/C15H12ClN3O/c16-12-6-7-15(20)14(9-12)19-10-13(17-18-19)8-11-4-2-1-3-5-11/h1-7,9-10,20H,8H2
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n/an/a 178n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412633
PNG
(CHEMBL506373)
Show SMILES COc1cc(ccc1NC(=O)c1ccccc1O)[N+]([O-])=O
Show InChI InChI=1S/C14H12N2O5/c1-21-13-8-9(16(19)20)6-7-11(13)15-14(18)10-4-2-3-5-12(10)17/h2-8,17H,1H3,(H,15,18)
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n/an/a 191n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412634
PNG
(CHEMBL517012)
Show SMILES CCOC(=O)c1nnn(c1-c1ccc(cc1)[N+]([O-])=O)-c1ccc(Cl)cc1[N+]([O-])=O
Show InChI InChI=1S/C17H12ClN5O6/c1-2-29-17(24)15-16(10-3-6-12(7-4-10)22(25)26)21(20-19-15)13-8-5-11(18)9-14(13)23(27)28/h3-9H,2H2,1H3
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n/an/a 282n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412635
PNG
(CHEMBL455306)
Show SMILES Oc1ccc(Cl)cc1NC(=O)c1cc(Cl)ccc1O
Show InChI InChI=1S/C13H9Cl2NO3/c14-7-1-3-11(17)9(5-7)13(19)16-10-6-8(15)2-4-12(10)18/h1-6,17-18H,(H,16,19)
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n/an/a 372n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412636
PNG
(CHEMBL453712)
Show SMILES COc1ccc(cc1NC(=O)c1ccccc1O)[N+]([O-])=O
Show InChI InChI=1S/C14H12N2O5/c1-21-13-7-6-9(16(19)20)8-11(13)15-14(18)10-4-2-3-5-12(10)17/h2-8,17H,1H3,(H,15,18)
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n/an/a 447n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412637
PNG
(CHEMBL465950)
Show SMILES Oc1ccc(Cl)cc1-n1cc(nn1)C(=O)c1ccccc1
Show InChI InChI=1S/C15H10ClN3O2/c16-11-6-7-14(20)13(8-11)19-9-12(17-18-19)15(21)10-4-2-1-3-5-10/h1-9,20H
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n/an/a 646n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412638
PNG
(CHEMBL464249 | TCMDC-124051)
Show SMILES COc1cc(ccc1NC(=O)c1cc(Cl)ccc1O)[N+]([O-])=O
Show InChI InChI=1S/C14H11ClN2O5/c1-22-13-7-9(17(20)21)3-4-11(13)16-14(19)10-6-8(15)2-5-12(10)18/h2-7,18H,1H3,(H,16,19)
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n/an/a 692n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412639
PNG
(CHEMBL465109)
Show SMILES Oc1ccccc1C(=O)Nc1ccc(cc1O)[N+]([O-])=O
Show InChI InChI=1S/C13H10N2O5/c16-11-4-2-1-3-9(11)13(18)14-10-6-5-8(15(19)20)7-12(10)17/h1-7,16-17H,(H,14,18)
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n/an/a 1.45E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412640
PNG
(CHEMBL465454)
Show SMILES Oc1ccccc1C(=O)n1nnc2ccccc12
Show InChI InChI=1S/C13H9N3O2/c17-12-8-4-1-5-9(12)13(18)16-11-7-3-2-6-10(11)14-15-16/h1-8,17H
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n/an/a 1.55E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412641
PNG
(CHEMBL512408)
Show SMILES Oc1ccccc1C(=O)n1nnc2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C14H8F3N3O2/c15-14(16,17)8-5-6-11-10(7-8)18-19-20(11)13(22)9-3-1-2-4-12(9)21/h1-7,21H
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n/an/a 2.14E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412642
PNG
(CHEMBL465455)
Show SMILES Oc1ccccc1C(=O)n1nnc2cc(Cl)ccc12
Show InChI InChI=1S/C13H8ClN3O2/c14-8-5-6-11-10(7-8)15-16-17(11)13(19)9-3-1-2-4-12(9)18/h1-7,18H
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n/an/a 2.45E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412643
PNG
(CHEMBL499800)
Show SMILES Cc1ccc(NC(=O)c2ccccc2O)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C14H12N2O4/c1-9-6-7-11(12(8-9)16(19)20)15-14(18)10-4-2-3-5-13(10)17/h2-8,17H,1H3,(H,15,18)
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n/an/a 2.51E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412644
PNG
(CHEMBL465456)
Show SMILES Oc1ccc(cc1-n1nncc1-c1ccccc1)[N+]([O-])=O
Show InChI InChI=1S/C14H10N4O3/c19-14-7-6-11(18(20)21)8-12(14)17-13(9-15-16-17)10-4-2-1-3-5-10/h1-9,19H
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n/an/a 2.63E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412645
PNG
(CHEMBL526140)
Show SMILES Oc1ccccc1C(=O)n1nnc2cc(F)ccc12
Show InChI InChI=1S/C13H8FN3O2/c14-8-5-6-11-10(7-8)15-16-17(11)13(19)9-3-1-2-4-12(9)18/h1-7,18H
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n/an/a 3.02E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412646
PNG
(CHEMBL481576)
Show SMILES Oc1ccccc1C(=O)Nc1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C13H10N2O4/c16-12-8-4-1-5-9(12)13(17)14-10-6-2-3-7-11(10)15(18)19/h1-8,16H,(H,14,17)
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n/an/a 3.09E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM67581
PNG
(MLS000050452 | N-(5-chloranyl-2-oxidanyl-phenyl)-2...)
Show SMILES CCOc1ccccc1C(=O)Nc1cc(Cl)ccc1O
Show InChI InChI=1S/C15H14ClNO3/c1-2-20-14-6-4-3-5-11(14)15(19)17-12-9-10(16)7-8-13(12)18/h3-9,18H,2H2,1H3,(H,17,19)
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n/an/a 3.09E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412647
PNG
(CHEMBL481578)
Show SMILES Oc1ccccc1C(=O)n1nnc2cc(ccc12)-c1ccccc1
Show InChI InChI=1S/C19H13N3O2/c23-18-9-5-4-8-15(18)19(24)22-17-11-10-14(12-16(17)20-21-22)13-6-2-1-3-7-13/h1-12,23H
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n/an/a 3.31E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412648
PNG
(CHEMBL519785)
Show SMILES Oc1ccccc1C(=O)Nc1ccc(cc1[N+]([O-])=O)C(F)(F)F
Show InChI InChI=1S/C14H9F3N2O4/c15-14(16,17)8-5-6-10(11(7-8)19(22)23)18-13(21)9-3-1-2-4-12(9)20/h1-7,20H,(H,18,21)
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n/an/a 3.47E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412649
PNG
(CHEMBL480795)
Show SMILES Cc1ccc(NC(=O)c2cc(Cl)ccc2O)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C14H11ClN2O4/c1-8-2-4-11(12(6-8)17(20)21)16-14(19)10-7-9(15)3-5-13(10)18/h2-7,18H,1H3,(H,16,19)
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n/an/a 4.07E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412650
PNG
(CHEMBL297914)
Show SMILES Oc1ccc(NC(=O)c2cc(Cl)ccc2O)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C13H9ClN2O5/c14-7-1-4-12(18)9(5-7)13(19)15-10-3-2-8(17)6-11(10)16(20)21/h1-6,17-18H,(H,15,19)
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n/an/a 5.25E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412651
PNG
(CHEMBL482376)
Show SMILES Oc1ccccc1C(=O)Nc1ccc(cc1[N+]([O-])=O)-c1ccccc1
Show InChI InChI=1S/C19H14N2O4/c22-18-9-5-4-8-15(18)19(23)20-16-11-10-14(12-17(16)21(24)25)13-6-2-1-3-7-13/h1-12,22H,(H,20,23)
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n/an/a 5.89E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50347497
PNG
(CHEMBL384903)
Show SMILES Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
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PubMed
n/an/a 5.89E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens)
BDBM50412652
PNG
(CHEMBL482377)
Show SMILES Oc1ccccc1C(=O)Nc1ccc(Cl)cc1[N+]([O-])=O
Show InChI InChI=1S/C13H9ClN2O4/c14-8-5-6-10(11(7-8)16(19)20)15-13(18)9-3-1-2-4-12(9)17/h1-7,17H,(H,15,18)
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PubMed
n/an/a 6.92E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
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