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Compile Data Set for Download or QSAR

Found 455 hits Enz. Inhib. hit(s) with Target = 'Cathepsin G'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin G


(Homo sapiens (Human))
BDBM50329819
PNG
((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)b...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)c1cccc(n1)-c1ccccc1)[C@@H](C)O)B(O)O
Show InChI InChI=1S/C21H28BN3O5/c1-13(2)12-18(22(29)30)24-21(28)19(14(3)26)25-20(27)17-11-7-10-16(23-17)15-8-5-4-6-9-15/h4-11,13-14,18-19,26,29-30H,12H2,1-3H3,(H,24,28)(H,25,27)/t14-,18+,19+/m1/s1
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n/an/an/an/a 13.5n/an/an/an/a



Aristotle University of Thessaloniki

Curated by ChEMBL


Assay Description
Inhibition of cathepsin G in human MOLT4 cells


J Med Chem 53: 6779-810 (2010)


Article DOI: 10.1021/jm100189a
BindingDB Entry DOI: 10.7270/Q29C6XPM
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM21737
PNG
(2-[(1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,40S,43S,4...)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N2)[C@@H](C)O)[C@@H](C)CC
Show InChI InChI=1/C67H104N18O18S2/c1-6-35(3)51-62(99)79-44-33-104-105-34-45(78-55(92)39(20-13-25-71-67(69)70)73-49(88)31-72-54(91)41(30-50(89)90)75-60(97)46-21-14-26-83(46)64(101)42(76-58(44)95)29-38-17-9-8-10-18-38)59(96)82-53(37(5)87)63(100)74-40(19-11-12-24-68)56(93)77-43(32-86)57(94)81-52(36(4)7-2)66(103)85-28-16-23-48(85)65(102)84-27-15-22-47(84)61(98)80-51/h8-10,17-18,35-37,39-48,51-53,86-87H,6-7,11-16,19-34,68H2,1-5H3,(H,72,91)(H,73,88)(H,74,100)(H,75,97)(H,76,95)(H,77,93)(H,78,92)(H,79,99)(H,80,98)(H,81,94)(H,82,96)(H,89,90)(H4,69,70,71)/t35-,36-,37+,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,51-,52-,53-/s2
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0.150n/an/an/an/an/an/an/an/a



University of Gda£?sk

Curated by ChEMBL


Assay Description
Inhibition of cathepsin G (unknown origin)


Bioorg Med Chem 17: 3302-7 (2009)


Article DOI: 10.1016/j.bmc.2009.03.045
BindingDB Entry DOI: 10.7270/Q2959HG1
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50034580
PNG
(CHEMBL418050 | Peptide boronate)
Show SMILES CC1(C)C2CC1[C@]1(C)OB(O[C@@H]1C2)C(Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C46H52BN3O6/c1-45(2)35-28-37(45)46(3)38(29-35)55-47(56-46)39(27-31-17-8-4-9-18-31)48-42(51)36-25-16-26-50(36)43(52)41(49-44(53)54-30-32-19-10-5-11-20-32)40(33-21-12-6-13-22-33)34-23-14-7-15-24-34/h4-15,17-24,35-41H,16,25-30H2,1-3H3,(H,48,51)(H,49,53)/t35?,36-,37?,38+,39?,41-,46-/m0/s1
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0.174n/an/an/an/an/an/an/an/a



Thrombosis Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against cathepsin G


J Med Chem 38: 1511-22 (1995)


Article DOI: 10.1021/jm00009a012
BindingDB Entry DOI: 10.7270/Q2QR4W57
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50034585
PNG
(CHEMBL285285 | Peptide boronate)
Show SMILES CC1(C)C2CC1[C@]1(C)OB(O[C@@H]1C2)C(Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C40H48BN3O6/c1-39(2)30-24-33(39)40(3)34(25-30)49-41(50-40)35(23-28-16-9-5-10-17-28)43-36(45)32-20-13-21-44(32)37(46)31(22-27-14-7-4-8-15-27)42-38(47)48-26-29-18-11-6-12-19-29/h4-12,14-19,30-35H,13,20-26H2,1-3H3,(H,42,47)(H,43,45)/t30?,31-,32-,33?,34+,35?,40-/m0/s1
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0.187n/an/an/an/an/an/an/an/a



Thrombosis Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against cathepsin G


J Med Chem 38: 1511-22 (1995)


Article DOI: 10.1021/jm00009a012
BindingDB Entry DOI: 10.7270/Q2QR4W57
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50034582
PNG
(CHEMBL2448441 | Peptide boronate)
Show SMILES Br.CC1(C)C2CC1[C@]1(C)OB(O[C@@H]1C2)C(CCC\C(S)=N\N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C37H50BN5O6S.BrH/c1-36(2)26-21-29(36)37(3)30(22-26)48-38(49-37)31(17-10-18-32(50)42-39)41-33(44)28-16-11-19-43(28)34(45)27(20-24-12-6-4-7-13-24)40-35(46)47-23-25-14-8-5-9-15-25;/h4-9,12-15,26-31H,10-11,16-23,39H2,1-3H3,(H,40,46)(H,41,44)(H,42,50);1H/t26?,27-,28-,29?,30+,31?,37-;/m0./s1
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0.437n/an/an/an/an/an/an/an/a



Thrombosis Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against cathepsin G


J Med Chem 38: 1511-22 (1995)


Article DOI: 10.1021/jm00009a012
BindingDB Entry DOI: 10.7270/Q2QR4W57
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50266979
PNG
(CHEMBL4061897)
Show SMILES CCCCC1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc3ccccc3)NC1=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2
Show InChI InChI=1S/C70H101N15O17S2/c1-7-10-24-43-59(91)74-44(31-41-20-13-11-14-21-41)60(92)77-47(35-86)61(93)82-56(39(5)9-3)70(102)85-30-19-27-52(85)69(101)84-29-18-26-51(84)65(97)81-55(38(4)8-2)66(98)78-49-37-104-103-36-48(62(94)73-43)79-67(99)57(40(6)87)80-54(89)34-72-58(90)45(33-53(71)88)75-64(96)50-25-17-28-83(50)68(100)46(76-63(49)95)32-42-22-15-12-16-23-42/h11-16,20-23,38-40,43-52,55-57,86-87H,7-10,17-19,24-37H2,1-6H3,(H2,71,88)(H,72,90)(H,73,94)(H,74,91)(H,75,96)(H,76,95)(H,77,92)(H,78,98)(H,79,99)(H,80,89)(H,81,97)(H,82,93)/t38-,39-,40+,43?,44-,45-,46-,47-,48-,49-,50-,51-,52-,55-,56-,57-/m0/s1
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0.890n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50034579
PNG
(CHEMBL290577 | Peptide boronate)
Show SMILES CCC(C)(C)C(NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)B1O[C@@H]2CC3CC(C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C38H52BN3O6/c1-7-36(2,3)34(39-47-31-23-27-22-30(37(27,4)5)38(31,6)48-39)41-32(43)29-19-14-20-42(29)33(44)28(21-25-15-10-8-11-16-25)40-35(45)46-24-26-17-12-9-13-18-26/h8-13,15-18,27-31,34H,7,14,19-24H2,1-6H3,(H,40,45)(H,41,43)/t27?,28-,29-,30?,31+,34?,38-/m0/s1
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0.916n/an/an/an/an/an/an/an/a



Thrombosis Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against cathepsin G


J Med Chem 38: 1511-22 (1995)


Article DOI: 10.1021/jm00009a012
BindingDB Entry DOI: 10.7270/Q2QR4W57
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50266982
PNG
(CHEMBL4077874)
Show SMILES CCCCC1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3ccccc3)NC1=O)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2
Show InChI InChI=1S/C69H97N15O19S2/c1-5-7-21-41-58(92)74-43(30-39-17-10-8-11-18-39)59(93)77-46(34-85)60(94)73-42(25-26-54(89)90)67(101)84-29-16-24-51(84)69(103)83-28-15-23-50(83)64(98)81-55(37(3)6-2)65(99)78-48-36-105-104-35-47(61(95)72-41)79-66(100)56(38(4)86)80-53(88)33-71-57(91)44(32-52(70)87)75-63(97)49-22-14-27-82(49)68(102)45(76-62(48)96)31-40-19-12-9-13-20-40/h8-13,17-20,37-38,41-51,55-56,85-86H,5-7,14-16,21-36H2,1-4H3,(H2,70,87)(H,71,91)(H,72,95)(H,73,94)(H,74,92)(H,75,97)(H,76,96)(H,77,93)(H,78,99)(H,79,100)(H,80,88)(H,81,98)(H,89,90)/t37-,38+,41?,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,55-,56-/m0/s1
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1.10n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50266984
PNG
(CHEMBL4092637)
Show SMILES CCCCC1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3ccc(NC(N)=N)cc3)NC1=O)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2
Show InChI InChI=1S/C69H98N18O19S2/c1-5-7-16-40-57(95)76-41(27-38-20-22-39(23-21-38)74-69(71)72)58(96)80-45(32-88)59(97)79-44(30-53(92)93)67(105)87-26-13-19-50(87)68(106)86-25-12-18-49(86)63(101)84-54(35(3)6-2)64(102)81-47-34-108-107-33-46(60(98)75-40)82-65(103)55(36(4)89)83-52(91)31-73-56(94)42(29-51(70)90)77-62(100)48-17-11-24-85(48)66(104)43(78-61(47)99)28-37-14-9-8-10-15-37/h8-10,14-15,20-23,35-36,40-50,54-55,88-89H,5-7,11-13,16-19,24-34H2,1-4H3,(H2,70,90)(H,73,94)(H,75,98)(H,76,95)(H,77,100)(H,78,99)(H,79,97)(H,80,96)(H,81,102)(H,82,103)(H,83,91)(H,84,101)(H,92,93)(H4,71,72,74)/t35-,36+,40?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,54-,55-/m0/s1
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1.60n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50266989
PNG
(CHEMBL4081142)
Show SMILES CCCCC1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3ccccc3)NC1=O)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2
Show InChI InChI=1S/C68H95N15O19S2/c1-5-7-21-40-57(91)72-41(28-38-17-10-8-11-18-38)58(92)76-45(33-84)59(93)75-44(31-53(88)89)67(101)83-27-16-24-50(83)68(102)82-26-15-23-49(82)63(97)80-54(36(3)6-2)64(98)77-47-35-104-103-34-46(60(94)71-40)78-65(99)55(37(4)85)79-52(87)32-70-56(90)42(30-51(69)86)73-62(96)48-22-14-25-81(48)66(100)43(74-61(47)95)29-39-19-12-9-13-20-39/h8-13,17-20,36-37,40-50,54-55,84-85H,5-7,14-16,21-35H2,1-4H3,(H2,69,86)(H,70,90)(H,71,94)(H,72,91)(H,73,96)(H,74,95)(H,75,93)(H,76,92)(H,77,98)(H,78,99)(H,79,87)(H,80,97)(H,88,89)/t36-,37+,40?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,54-,55-/m0/s1
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1.70n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50266987
PNG
(CHEMBL4097952)
Show SMILES CCCCC1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)C(Cc3ccc(cc3)-c3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3ccccc3)NC1=O)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2
Show InChI InChI=1S/C79H103N15O17S2/c1-5-7-26-52-68(100)83-53(37-47-20-11-8-12-21-47)69(101)87-57(42-95)70(102)85-56(39-49-30-32-51(33-31-49)50-24-15-10-16-25-50)78(110)94-36-19-29-62(94)79(111)93-35-18-28-61(93)74(106)91-65(45(3)6-2)75(107)88-59-44-113-112-43-58(71(103)82-52)89-76(108)66(46(4)96)90-64(98)41-81-67(99)54(40-63(80)97)84-73(105)60-27-17-34-92(60)77(109)55(86-72(59)104)38-48-22-13-9-14-23-48/h8-16,20-25,30-33,45-46,52-62,65-66,95-96H,5-7,17-19,26-29,34-44H2,1-4H3,(H2,80,97)(H,81,99)(H,82,103)(H,83,100)(H,84,105)(H,85,102)(H,86,104)(H,87,101)(H,88,107)(H,89,108)(H,90,98)(H,91,106)/t45-,46+,52?,53-,54-,55-,56?,57-,58-,59-,60-,61-,62-,65-,66-/m0/s1
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2.90n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50266999
PNG
(CHEMBL4069983)
Show SMILES CCCCC1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc3ccccc3)NC1=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N2
Show InChI InChI=1S/C72H104N14O17S2/c1-8-12-26-45-61(92)75-46(33-43-22-15-13-16-23-43)62(93)78-49(37-87)63(94)83-59(42(7)11-4)72(103)86-32-21-29-54(86)71(102)85-31-20-28-53(85)67(98)82-58(41(6)10-3)69(100)80-51-39-105-104-38-50(64(95)74-45)79-68(99)57(40(5)9-2)81-55(88)36-73-60(91)47(35-56(89)90)76-66(97)52-27-19-30-84(52)70(101)48(77-65(51)96)34-44-24-17-14-18-25-44/h13-18,22-25,40-42,45-54,57-59,87H,8-12,19-21,26-39H2,1-7H3,(H,73,91)(H,74,95)(H,75,92)(H,76,97)(H,77,96)(H,78,93)(H,79,99)(H,80,100)(H,81,88)(H,82,98)(H,83,94)(H,89,90)/t40-,41-,42-,45?,46-,47-,48-,49-,50-,51-,52-,53-,54-,57-,58-,59-/m0/s1
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3.40n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50034577
PNG
(CHEMBL291026 | Peptide boronate)
Show SMILES CCCCCC(NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)B1O[C@@H]2CC3CC(C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C38H52BN3O6/c1-5-6-9-20-33(39-47-32-24-28-23-31(37(28,2)3)38(32,4)48-39)41-34(43)30-19-14-21-42(30)35(44)29(22-26-15-10-7-11-16-26)40-36(45)46-25-27-17-12-8-13-18-27/h7-8,10-13,15-18,28-33H,5-6,9,14,19-25H2,1-4H3,(H,40,45)(H,41,43)/t28?,29-,30-,31?,32+,33?,38-/m0/s1
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3.74n/an/an/an/an/an/an/an/a



Thrombosis Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against cathepsin G


J Med Chem 38: 1511-22 (1995)


Article DOI: 10.1021/jm00009a012
BindingDB Entry DOI: 10.7270/Q2QR4W57
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50034576
PNG
(CHEMBL288176 | Peptide boronate)
Show SMILES CCC(C)(C)C(NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)OCc1ccccc1)B1O[C@@H]2CC3CC(C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C42H54BN3O6/c1-7-40(2,3)38(43-51-35-25-31-24-34(41(31,4)5)42(35,6)52-43)45-36(47)33-18-13-21-46(33)37(48)32(44-39(49)50-26-27-14-9-8-10-15-27)23-28-19-20-29-16-11-12-17-30(29)22-28/h8-12,14-17,19-20,22,31-35,38H,7,13,18,21,23-26H2,1-6H3,(H,44,49)(H,45,47)/t31?,32-,33-,34?,35+,38?,42-/m0/s1
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3.85n/an/an/an/an/an/an/an/a



Thrombosis Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against cathepsin G


J Med Chem 38: 1511-22 (1995)


Article DOI: 10.1021/jm00009a012
BindingDB Entry DOI: 10.7270/Q2QR4W57
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50034574
PNG
(CHEMBL288150 | Peptide boronate)
Show SMILES COCCCC(NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)B1O[C@@H]2CC3CC(C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C37H50BN3O7/c1-36(2)27-22-30(36)37(3)31(23-27)47-38(48-37)32(18-12-20-45-4)40-33(42)29-17-11-19-41(29)34(43)28(21-25-13-7-5-8-14-25)39-35(44)46-24-26-15-9-6-10-16-26/h5-10,13-16,27-32H,11-12,17-24H2,1-4H3,(H,39,44)(H,40,42)/t27?,28-,29-,30?,31+,32?,37-/m0/s1
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3.90n/an/an/an/an/an/an/an/a



Thrombosis Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against cathepsin G


J Med Chem 38: 1511-22 (1995)


Article DOI: 10.1021/jm00009a012
BindingDB Entry DOI: 10.7270/Q2QR4W57
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50266981
PNG
(CHEMBL4070520)
Show SMILES CCCCC1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)C(CCCC)NC(=O)[C@H](Cc3ccccc3)NC1=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2
Show InChI InChI=1S/C73H106N14O17S2/c1-8-12-27-46-62(93)77-48(35-44-23-16-14-17-24-44)64(95)75-47(28-13-9-2)63(94)84-59(42(6)11-4)73(104)87-34-22-31-55(87)72(103)86-33-21-30-54(86)68(99)83-58(41(5)10-3)69(100)80-52-40-106-105-39-51(65(96)76-46)81-70(101)60(43(7)88)82-56(89)38-74-61(92)49(37-57(90)91)78-67(98)53-29-20-32-85(53)71(102)50(79-66(52)97)36-45-25-18-15-19-26-45/h14-19,23-26,41-43,46-55,58-60,88H,8-13,20-22,27-40H2,1-7H3,(H,74,92)(H,75,95)(H,76,96)(H,77,93)(H,78,98)(H,79,97)(H,80,100)(H,81,101)(H,82,89)(H,83,99)(H,84,94)(H,90,91)/t41-,42-,43+,46?,47?,48-,49-,50-,51-,52-,53-,54-,55-,58-,59-,60-/m0/s1
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4.80n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50266980
PNG
(CHEMBL4097688)
Show SMILES CCCCC1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc3ccccc3)NC1=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N2
Show InChI InChI=1S/C72H105N15O16S2/c1-8-12-26-45-61(92)76-46(33-43-22-15-13-16-23-43)62(93)79-49(37-88)63(94)84-59(42(7)11-4)72(103)87-32-21-29-54(87)71(102)86-31-20-28-53(86)67(98)83-58(41(6)10-3)69(100)81-51-39-105-104-38-50(64(95)75-45)80-68(99)57(40(5)9-2)82-56(90)36-74-60(91)47(35-55(73)89)77-66(97)52-27-19-30-85(52)70(101)48(78-65(51)96)34-44-24-17-14-18-25-44/h13-18,22-25,40-42,45-54,57-59,88H,8-12,19-21,26-39H2,1-7H3,(H2,73,89)(H,74,91)(H,75,95)(H,76,92)(H,77,97)(H,78,96)(H,79,93)(H,80,99)(H,81,100)(H,82,90)(H,83,98)(H,84,94)/t40-,41-,42-,45?,46-,47-,48-,49-,50-,51-,52-,53-,54-,57-,58-,59-/m0/s1
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4.90n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50266998
PNG
(CHEMBL4088524)
Show SMILES CCCCC1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc3ccccc3)NC1=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2
Show InChI InChI=1S/C70H100N14O18S2/c1-7-10-24-43-59(91)73-44(31-41-20-13-11-14-21-41)60(92)76-47(35-85)61(93)81-56(39(5)9-3)70(102)84-30-19-27-52(84)69(101)83-29-18-26-51(83)65(97)80-55(38(4)8-2)66(98)77-49-37-104-103-36-48(62(94)72-43)78-67(99)57(40(6)86)79-53(87)34-71-58(90)45(33-54(88)89)74-64(96)50-25-17-28-82(50)68(100)46(75-63(49)95)32-42-22-15-12-16-23-42/h11-16,20-23,38-40,43-52,55-57,85-86H,7-10,17-19,24-37H2,1-6H3,(H,71,90)(H,72,94)(H,73,91)(H,74,96)(H,75,95)(H,76,92)(H,77,98)(H,78,99)(H,79,87)(H,80,97)(H,81,93)(H,88,89)/t38-,39-,40+,43?,44-,45-,46-,47-,48-,49-,50-,51-,52-,55-,56-,57-/m0/s1
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7.30n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50266985
PNG
(CHEMBL3623771)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2)[C@@H](C)O
Show InChI InChI=1S/C58H91N19O21S2/c1-5-25(2)42-52(93)70-33-23-99-100-24-34(71-53(94)43(26(3)79)72-40(83)21-64-45(86)29(18-38(59)81)66-50(91)35-11-7-15-75(35)55(96)30(19-39(60)82)67-48(33)89)49(90)74-44(27(4)80)54(95)65-28(10-6-14-63-58(61)62)46(87)69-32(22-78)47(88)68-31(20-41(84)85)56(97)77-17-9-13-37(77)57(98)76-16-8-12-36(76)51(92)73-42/h25-37,42-44,78-80H,5-24H2,1-4H3,(H2,59,81)(H2,60,82)(H,64,86)(H,65,95)(H,66,91)(H,67,89)(H,68,88)(H,69,87)(H,70,93)(H,71,94)(H,72,83)(H,73,92)(H,74,90)(H,84,85)(H4,61,62,63)/t25-,26+,27+,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,42-,43-,44-/m0/s1
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12n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50266988
PNG
(CHEMBL4105401)
Show SMILES CCCCC1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)C(CCCC)NC(=O)[C@H](Cc3ccccc3)NC1=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2
Show InChI InChI=1S/C73H107N15O16S2/c1-8-12-27-46-62(93)78-48(35-44-23-16-14-17-24-44)64(95)76-47(28-13-9-2)63(94)85-59(42(6)11-4)73(104)88-34-22-31-55(88)72(103)87-33-21-30-54(87)68(99)84-58(41(5)10-3)69(100)81-52-40-106-105-39-51(65(96)77-46)82-70(101)60(43(7)89)83-57(91)38-75-61(92)49(37-56(74)90)79-67(98)53-29-20-32-86(53)71(102)50(80-66(52)97)36-45-25-18-15-19-26-45/h14-19,23-26,41-43,46-55,58-60,89H,8-13,20-22,27-40H2,1-7H3,(H2,74,90)(H,75,92)(H,76,95)(H,77,96)(H,78,93)(H,79,98)(H,80,97)(H,81,100)(H,82,101)(H,83,91)(H,84,99)(H,85,94)/t41-,42-,43+,46?,47?,48-,49-,50-,51-,52-,53-,54-,55-,58-,59-,60-/m0/s1
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12n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50034583
PNG
(CHEMBL287918 | Peptide boronate)
Show SMILES CCCCCC(NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(c1ccccc1)c1ccccc1)B1O[C@@H]2CC3CC(C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C44H56BN3O6/c1-5-6-10-25-37(45-53-36-28-33-27-35(43(33,2)3)44(36,4)54-45)46-40(49)34-24-17-26-48(34)41(50)39(47-42(51)52-29-30-18-11-7-12-19-30)38(31-20-13-8-14-21-31)32-22-15-9-16-23-32/h7-9,11-16,18-23,33-39H,5-6,10,17,24-29H2,1-4H3,(H,46,49)(H,47,51)/t33?,34-,35?,36+,37?,39-,44-/m0/s1
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14.3n/an/an/an/an/an/an/an/a



Thrombosis Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against cathepsin G


J Med Chem 38: 1511-22 (1995)


Article DOI: 10.1021/jm00009a012
BindingDB Entry DOI: 10.7270/Q2QR4W57
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50034581
PNG
(CHEMBL36744 | Peptide boronate)
Show SMILES COCCCC(NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(c1ccccc1)c1ccccc1)B1O[C@@H]2CC3CC(C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C43H54BN3O7/c1-42(2)32-26-34(42)43(3)35(27-32)53-44(54-43)36(23-15-25-51-4)45-39(48)33-22-14-24-47(33)40(49)38(46-41(50)52-28-29-16-8-5-9-17-29)37(30-18-10-6-11-19-30)31-20-12-7-13-21-31/h5-13,16-21,32-38H,14-15,22-28H2,1-4H3,(H,45,48)(H,46,50)/t32?,33-,34?,35+,36?,38-,43-/m0/s1
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25.3n/an/an/an/an/an/an/an/a



Thrombosis Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against cathepsin G


J Med Chem 38: 1511-22 (1995)


Article DOI: 10.1021/jm00009a012
BindingDB Entry DOI: 10.7270/Q2QR4W57
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50208224
PNG
(2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carba...)
Show SMILES CN(C1CCN(CC1)C(=O)c1ccc2ccccc2c1)C(=O)c1cc2ccccc2cc1C(=O)C(c1cccc2ccccc12)P(O)(O)=O
Show InChI InChI=1/C40H35N2O6P/c1-41(32-19-21-42(22-20-32)39(44)31-18-17-26-9-2-3-11-28(26)23-31)40(45)36-25-30-13-5-4-12-29(30)24-35(36)37(43)38(49(46,47)48)34-16-8-14-27-10-6-7-15-33(27)34/h2-18,23-25,32,38H,19-22H2,1H3,(H2,46,47,48)
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38n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human neutrophil Cat G


J Med Chem 50: 1727-30 (2007)


Article DOI: 10.1021/jm0700619
BindingDB Entry DOI: 10.7270/Q26W99RF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cathepsin G


(Homo sapiens (Human))
BDBM50034573
PNG
(CHEMBL291261 | Peptide boronate)
Show SMILES CCC(C)(C)C(NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(c1ccccc1)c1ccccc1)B1O[C@@H]2CC3CC(C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C44H56BN3O6/c1-7-42(2,3)40(45-53-35-27-32-26-34(43(32,4)5)44(35,6)54-45)47-38(49)33-24-17-25-48(33)39(50)37(46-41(51)52-28-29-18-11-8-12-19-29)36(30-20-13-9-14-21-30)31-22-15-10-16-23-31/h8-16,18-23,32-37,40H,7,17,24-28H2,1-6H3,(H,46,51)(H,47,49)/t32?,33-,34?,35+,37-,40?,44-/m0/s1
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44.1n/an/an/an/an/an/an/an/a



Thrombosis Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against cathepsin G


J Med Chem 38: 1511-22 (1995)


Article DOI: 10.1021/jm00009a012
BindingDB Entry DOI: 10.7270/Q2QR4W57
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50266986
PNG
(CHEMBL4089025)
Show SMILES CCCCC1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc3ccccc3)NC1=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2
Show InChI InChI=1S/C65H98N16O18S2/c1-7-10-19-37-54(88)70-38(26-36-17-12-11-13-18-36)55(89)73-41(30-82)56(90)78-51(34(5)9-3)65(99)81-25-16-22-46(81)64(98)80-24-15-21-45(80)60(94)77-50(33(4)8-2)61(95)74-43-32-101-100-31-42(57(91)69-37)75-62(96)52(35(6)83)76-49(86)29-68-53(87)39(27-47(66)84)71-59(93)44-20-14-23-79(44)63(97)40(28-48(67)85)72-58(43)92/h11-13,17-18,33-35,37-46,50-52,82-83H,7-10,14-16,19-32H2,1-6H3,(H2,66,84)(H2,67,85)(H,68,87)(H,69,91)(H,70,88)(H,71,93)(H,72,92)(H,73,89)(H,74,95)(H,75,96)(H,76,86)(H,77,94)(H,78,90)/t33-,34-,35+,37?,38-,39-,40-,41-,42-,43-,44-,45-,46-,50-,51-,52-/m0/s1
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62n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM113301
PNG
(US9695194, 17)
Show SMILES COc1ccc(c(OC)c1)-c1nc2cc(OC)c(OC)cc2c(=O)o1
Show InChI InChI=1S/C18H17NO6/c1-21-10-5-6-11(14(7-10)22-2)17-19-13-9-16(24-4)15(23-3)8-12(13)18(20)25-17/h5-9H,1-4H3
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100 -41.6n/an/an/an/an/a7.237



SIXERA Pharma AB

US Patent


Assay Description
Materials: Cathepsin G, 100 mU (VWR, Calbiochem, cat. no. 219373), Substrate Cathepsin G substrate (VWR, Calbiochem, cat. no. 219407). Cathepsin acti...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50266997
PNG
(CHEMBL4078196)
Show SMILES CCCCC1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc3ccccc3)NC1=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N2
Show InChI InChI=1S/C70H98N14O19S2/c1-6-9-23-42-59(92)74-43(30-40-19-12-10-13-20-40)60(93)77-47(35-85)62(95)81-57(39(5)8-3)70(103)84-29-18-26-52(84)69(102)83-28-17-25-51(83)66(99)80-56(38(4)7-2)67(100)79-49-37-105-104-36-48(63(96)73-42)78-61(94)45(33-55(89)90)72-53(86)34-71-58(91)44(32-54(87)88)75-65(98)50-24-16-27-82(50)68(101)46(76-64(49)97)31-41-21-14-11-15-22-41/h10-15,19-22,38-39,42-52,56-57,85H,6-9,16-18,23-37H2,1-5H3,(H,71,91)(H,72,86)(H,73,96)(H,74,92)(H,75,98)(H,76,97)(H,77,93)(H,78,94)(H,79,100)(H,80,99)(H,81,95)(H,87,88)(H,89,90)/t38-,39-,42?,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,56-,57-/m0/s1
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160n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50014741
PNG
(CHEMBL130190 | N-{1-[2-(1-Benzyl-3,3,3-trifluoro-2...)
Show SMILES COC(=O)CCC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C25H32F3N3O6/c1-15(2)21(30-19(32)11-12-20(33)37-3)24(36)31-13-7-10-18(31)23(35)29-17(22(34)25(26,27)28)14-16-8-5-4-6-9-16/h4-6,8-9,15,17-18,21H,7,10-14H2,1-3H3,(H,29,35)(H,30,32)/t17-,18-,21-/m0/s1
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200n/an/an/an/an/an/an/an/a



Merrell Dow Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against rat Cathepsin G


J Med Chem 33: 394-407 (1990)


Article DOI: 10.1021/jm00163a063
BindingDB Entry DOI: 10.7270/Q26D5RZ5
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM113297
PNG
(US9695194, 14)
Show SMILES CS(=O)(=O)c1ccccc1-c1nc2cc3OCCOc3cc2c(=O)o1
Show InChI InChI=1S/C17H13NO6S/c1-25(20,21)15-5-3-2-4-10(15)16-18-12-9-14-13(22-6-7-23-14)8-11(12)17(19)24-16/h2-5,8-9H,6-7H2,1H3
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200 -39.8n/an/an/an/an/a7.237



SIXERA Pharma AB

US Patent


Assay Description
Materials: Cathepsin G, 100 mU (VWR, Calbiochem, cat. no. 219373), Substrate Cathepsin G substrate (VWR, Calbiochem, cat. no. 219407). Cathepsin acti...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50014731
PNG
(3-[(1-{2-[2-(3-Methoxycarbonyl-propionylamino)-pro...)
Show SMILES COC(=O)CCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)OC
Show InChI InChI=1S/C27H36N4O9/c1-16(28-21(32)12-13-22(33)39-3)24(35)29-17(2)26(37)31-14-8-11-20(31)25(36)30-19(23(34)27(38)40-4)15-18-9-6-5-7-10-18/h5-7,9-10,16-17,19-20H,8,11-15H2,1-4H3,(H,28,32)(H,29,35)(H,30,36)/t16-,17-,19-,20-/m0/s1
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200n/an/an/an/an/an/an/an/a



Merrell Dow Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against rat Cathepsin G


J Med Chem 33: 394-407 (1990)


Article DOI: 10.1021/jm00163a063
BindingDB Entry DOI: 10.7270/Q26D5RZ5
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50058391
PNG
((S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-but...)
Show SMILES COc1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
Show InChI InChI=1S/C24H32F3N3O5/c1-13(2)18(20(31)24(25,26)27)28-22(33)17-7-6-12-30(17)23(34)19(14(3)4)29-21(32)15-8-10-16(35-5)11-9-15/h8-11,13-14,17-19H,6-7,12H2,1-5H3,(H,28,33)(H,29,32)/t17-,18-,19-/m0/s1
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250n/an/an/an/an/an/an/an/a



Zeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity of the compound for human leukocyte cathepsin G


J Med Chem 40: 3173-81 (1997)


Article DOI: 10.1021/jm970250z
BindingDB Entry DOI: 10.7270/Q2GT5M85
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50098853
PNG
(2-(2-{2-[5-Amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyr...)
Show SMILES COC(=O)c1ccc2oc(nc2c1)C(=O)C(Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1cccc(OC)c1
Show InChI InChI=1/C31H27N5O7/c1-41-21-10-6-9-19(14-21)28-33-16-22(32)30(39)36(28)17-26(37)34-24(13-18-7-4-3-5-8-18)27(38)29-35-23-15-20(31(40)42-2)11-12-25(23)43-29/h3-12,14-16,24H,13,17,32H2,1-2H3,(H,34,37)
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379n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against human cathepsin G


J Med Chem 44: 1286-96 (2001)


Article DOI: 10.1021/jm000496v
BindingDB Entry DOI: 10.7270/Q26H4J4K
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50267000
PNG
(CHEMBL4083086)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2)[C@@H](C)O)[C@@H](C)CC
Show InChI InChI=1S/C63H94N16O19S2/c1-7-30(3)47-58(93)71-39-28-99-100-29-40(72-59(94)49(32(5)81)73-46(85)26-66-51(86)36(24-44(64)83)67-56(91)41-17-12-20-77(41)61(96)37(25-45(65)84)69-54(39)89)55(90)76-50(33(6)82)60(95)68-35(23-34-15-10-9-11-16-34)52(87)70-38(27-80)53(88)75-48(31(4)8-2)63(98)79-22-14-19-43(79)62(97)78-21-13-18-42(78)57(92)74-47/h9-11,15-16,30-33,35-43,47-50,80-82H,7-8,12-14,17-29H2,1-6H3,(H2,64,83)(H2,65,84)(H,66,86)(H,67,91)(H,68,95)(H,69,89)(H,70,87)(H,71,93)(H,72,94)(H,73,85)(H,74,92)(H,75,88)(H,76,90)/t30-,31-,32+,33+,35-,36-,37-,38-,39-,40-,41-,42-,43-,47-,48-,49-,50-/m0/s1
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390n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM113300
PNG
(US9695194, 16)
Show SMILES Clc1ccccc1-c1nc2cc3OCCOc3cc2c(=O)o1
Show InChI InChI=1S/C16H10ClNO4/c17-11-4-2-1-3-9(11)15-18-12-8-14-13(20-5-6-21-14)7-10(12)16(19)22-15/h1-4,7-8H,5-6H2
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400 -38.0n/an/an/an/an/a7.237



SIXERA Pharma AB

US Patent


Assay Description
Materials: Cathepsin G, 100 mU (VWR, Calbiochem, cat. no. 219373), Substrate Cathepsin G substrate (VWR, Calbiochem, cat. no. 219407). Cathepsin acti...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50267001
PNG
(CHEMBL4074776)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2)[C@@H](C)O)[C@@H](C)CC
Show InChI InChI=1S/C63H94N16O20S2/c1-7-29(3)47-58(94)71-39-27-100-101-28-40(72-59(95)49(31(5)81)73-46(86)25-66-51(87)36(23-44(64)84)67-56(92)41-12-9-19-77(41)61(97)37(24-45(65)85)69-54(39)90)55(91)76-50(32(6)82)60(96)68-35(22-33-15-17-34(83)18-16-33)52(88)70-38(26-80)53(89)75-48(30(4)8-2)63(99)79-21-11-14-43(79)62(98)78-20-10-13-42(78)57(93)74-47/h15-18,29-32,35-43,47-50,80-83H,7-14,19-28H2,1-6H3,(H2,64,84)(H2,65,85)(H,66,87)(H,67,92)(H,68,96)(H,69,90)(H,70,88)(H,71,94)(H,72,95)(H,73,86)(H,74,93)(H,75,89)(H,76,91)/t29-,30-,31+,32+,35-,36-,37-,38-,39-,40-,41-,42-,43-,47-,48-,49-,50-/m0/s1
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410n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50266992
PNG
(CHEMBL4095237)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2)[C@@H](C)O)[C@@H](C)CC
Show InChI InChI=1S/C60H96N16O19S2/c1-9-28(5)44-55(90)68-36-25-96-97-26-37(69-56(91)46(30(7)78)70-43(82)23-63-48(83)33(21-41(61)80)64-53(88)38-14-11-17-74(38)58(93)34(22-42(62)81)66-51(36)86)52(87)73-47(31(8)79)57(92)65-32(20-27(3)4)49(84)67-35(24-77)50(85)72-45(29(6)10-2)60(95)76-19-13-16-40(76)59(94)75-18-12-15-39(75)54(89)71-44/h27-40,44-47,77-79H,9-26H2,1-8H3,(H2,61,80)(H2,62,81)(H,63,83)(H,64,88)(H,65,92)(H,66,86)(H,67,84)(H,68,90)(H,69,91)(H,70,82)(H,71,89)(H,72,85)(H,73,87)/t28-,29-,30+,31+,32-,33-,34-,35-,36-,37-,38-,39-,40-,44-,45-,46-,47-/m0/s1
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480n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50124906
PNG
(CHEMBL3623776)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2)[C@@H](C)O)[C@@H](C)CC
Show InChI InChI=1/C60H97N19O19S2/c1-7-27(3)43-54(93)71-35-25-99-100-26-36(72-55(94)45(29(5)81)73-42(85)23-66-47(86)32(21-40(61)83)68-52(91)37-14-10-18-77(37)57(96)33(22-41(62)84)69-50(35)89)51(90)76-46(30(6)82)56(95)67-31(13-9-17-65-60(63)64)48(87)70-34(24-80)49(88)75-44(28(4)8-2)59(98)79-20-12-16-39(79)58(97)78-19-11-15-38(78)53(92)74-43/h27-39,43-46,80-82H,7-26H2,1-6H3,(H2,61,83)(H2,62,84)(H,66,86)(H,67,95)(H,68,91)(H,69,89)(H,70,87)(H,71,93)(H,72,94)(H,73,85)(H,74,92)(H,75,88)(H,76,90)(H4,63,64,65)/t27-,28-,29+,30+,31-,32-,33-,34-,35-,36-,37-,38-,39-,43-,44-,45-,46-/s2
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490n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM113293
PNG
(US9695194, 10)
Show SMILES CS(=O)(=O)c1ccccc1-c1nc2cc3OCCCOc3cc2c(=O)o1
Show InChI InChI=1S/C18H15NO6S/c1-26(21,22)16-6-3-2-5-11(16)17-19-13-10-15-14(23-7-4-8-24-15)9-12(13)18(20)25-17/h2-3,5-6,9-10H,4,7-8H2,1H3
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500 -37.4n/an/an/an/an/a7.237



SIXERA Pharma AB

US Patent


Assay Description
Materials: Cathepsin G, 100 mU (VWR, Calbiochem, cat. no. 219373), Substrate Cathepsin G substrate (VWR, Calbiochem, cat. no. 219407). Cathepsin acti...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM113299
PNG
(US9695194, 15)
Show SMILES COC1CC(OC)=CC=C1c1nc2cc3OCCOc3cc2c(=O)o1
Show InChI InChI=1/C18H17NO6/c1-21-10-3-4-11(14(7-10)22-2)17-19-13-9-16-15(23-5-6-24-16)8-12(13)18(20)25-17/h3-4,8-9,14H,5-7H2,1-2H3
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500 -37.4n/an/an/an/an/a7.237



SIXERA Pharma AB

US Patent


Assay Description
Materials: Cathepsin G, 100 mU (VWR, Calbiochem, cat. no. 219373), Substrate Cathepsin G substrate (VWR, Calbiochem, cat. no. 219407). Cathepsin acti...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50266994
PNG
(CHEMBL4103492)
Show SMILES CCCCC(NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C=O
Show InChI InChI=1S/C23H34N4O7/c1-3-4-10-18(22(33)25-16(13-28)11-15-8-6-5-7-9-15)26-23(34)20(14(2)29)27-21(32)17(24)12-19(30)31/h5-9,13-14,16-18,20,29H,3-4,10-12,24H2,1-2H3,(H,25,33)(H,26,34)(H,27,32)(H,30,31)/t14-,16+,17+,18?,20+/m1/s1
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530n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM113283
PNG
(US9695194, 8)
Show SMILES COc1ccc(c(OC)c1)-c1nc2cc3OCCCOc3cc2c(=O)o1
Show InChI InChI=1S/C19H17NO6/c1-22-11-4-5-12(15(8-11)23-2)18-20-14-10-17-16(24-6-3-7-25-17)9-13(14)19(21)26-18/h4-5,8-10H,3,6-7H2,1-2H3
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600 -36.9n/an/an/an/an/a7.237



SIXERA Pharma AB

US Patent


Assay Description
Materials: Cathepsin G, 100 mU (VWR, Calbiochem, cat. no. 219373), Substrate Cathepsin G substrate (VWR, Calbiochem, cat. no. 219407). Cathepsin acti...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50069989
PNG
((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
Show InChI InChI=1/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/s2
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630n/an/an/an/an/an/an/an/a



ProScript, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human cathepsin G


Bioorg Med Chem Lett 8: 333-8 (1999)


Article DOI: 10.1016/s0960-894x(98)00029-8
BindingDB Entry DOI: 10.7270/Q2RV0MVQ
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50266993
PNG
(CHEMBL4100180)
Show SMILES CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C=O
Show InChI InChI=1S/C24H34N4O8/c1-2-3-9-18(23(35)26-16(14-29)12-15-7-5-4-6-8-15)28-24(36)19(10-11-20(30)31)27-22(34)17(25)13-21(32)33/h4-8,14,16-19H,2-3,9-13,25H2,1H3,(H,26,35)(H,27,34)(H,28,36)(H,30,31)(H,32,33)/t16-,17-,18?,19-/m0/s1
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630n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM113119
PNG
(US9695194, 6)
Show SMILES COc1ccccc1-c1nc2cc3OCCCOc3cc2c(=O)o1
Show InChI InChI=1S/C18H15NO5/c1-21-14-6-3-2-5-11(14)17-19-13-10-16-15(22-7-4-8-23-16)9-12(13)18(20)24-17/h2-3,5-6,9-10H,4,7-8H2,1H3
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700 -36.5n/an/an/an/an/a7.237



SIXERA Pharma AB

US Patent


Assay Description
Materials: Cathepsin G, 100 mU (VWR, Calbiochem, cat. no. 219373), Substrate Cathepsin G substrate (VWR, Calbiochem, cat. no. 219407). Cathepsin acti...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM113296
PNG
(US9695194, 13)
Show SMILES COc1ccccc1-c1nc2cc3OCCOc3cc2c(=O)o1
Show InChI InChI=1S/C17H13NO5/c1-20-13-5-3-2-4-10(13)16-18-12-9-15-14(21-6-7-22-15)8-11(12)17(19)23-16/h2-5,8-9H,6-7H2,1H3
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700 -36.5n/an/an/an/an/a7.237



SIXERA Pharma AB

US Patent


Assay Description
Materials: Cathepsin G, 100 mU (VWR, Calbiochem, cat. no. 219373), Substrate Cathepsin G substrate (VWR, Calbiochem, cat. no. 219407). Cathepsin acti...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM113295
PNG
(US9695194, 12)
Show SMILES COc1cc2nc(oc(=O)c2cc1OC)-c1ccccc1SC
Show InChI InChI=1S/C17H15NO4S/c1-20-13-8-11-12(9-14(13)21-2)18-16(22-17(11)19)10-6-4-5-7-15(10)23-3/h4-9H,1-3H3
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700 -36.5n/an/an/an/an/a7.237



SIXERA Pharma AB

US Patent


Assay Description
Materials: Cathepsin G, 100 mU (VWR, Calbiochem, cat. no. 219373), Substrate Cathepsin G substrate (VWR, Calbiochem, cat. no. 219407). Cathepsin acti...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50098847
PNG
(2-(2-{2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyri...)
Show SMILES COC(=O)c1ccc2oc(nc2c1)C(=O)C(Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1ccc(F)cc1
Show InChI InChI=1/C30H24FN5O6/c1-41-30(40)19-9-12-24-22(14-19)35-28(42-24)26(38)23(13-17-5-3-2-4-6-17)34-25(37)16-36-27(33-15-21(32)29(36)39)18-7-10-20(31)11-8-18/h2-12,14-15,23H,13,16,32H2,1H3,(H,34,37)
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720n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against human cathepsin G


J Med Chem 44: 1286-96 (2001)


Article DOI: 10.1021/jm000496v
BindingDB Entry DOI: 10.7270/Q26H4J4K
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50124947
PNG
(CHEMBL453539)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O)[C@@H](C)CC
Show InChI InChI=1/C67H104N18O18S2/c1-6-35(3)51-62(99)79-44-33-104-105-34-45(78-55(92)39(20-13-25-71-67(69)70)73-49(88)31-72-54(91)41(30-50(89)90)75-60(97)46-21-14-26-83(46)64(101)42(76-58(44)95)29-38-17-9-8-10-18-38)59(96)82-53(37(5)87)63(100)74-40(19-11-12-24-68)56(93)77-43(32-86)57(94)81-52(36(4)7-2)66(103)85-28-16-23-48(85)65(102)84-27-15-22-47(84)61(98)80-51/h8-10,17-18,35-37,39-48,51-53,86-87H,6-7,11-16,19-34,68H2,1-5H3,(H,72,91)(H,73,88)(H,74,100)(H,75,97)(H,76,95)(H,77,93)(H,78,92)(H,79,99)(H,80,98)(H,81,94)(H,82,96)(H,89,90)(H4,69,70,71)/t35-,36-,37+,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,51-,52-,53-/s2
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730n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate after 30 mins


J Med Chem 60: 658-667 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM113067
PNG
(US9695194, 3)
Show SMILES CCOc1cc2c(cc1OC)nc(oc2=O)-c1ccc(OC)cc1OC
Show InChI InChI=1S/C19H19NO6/c1-5-25-17-9-13-14(10-16(17)24-4)20-18(26-19(13)21)12-7-6-11(22-2)8-15(12)23-3/h6-10H,5H2,1-4H3
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1.10E+3 -35.4n/an/an/an/an/a7.237



SIXERA Pharma AB

US Patent


Assay Description
Materials: Cathepsin G, 100 mU (VWR, Calbiochem, cat. no. 219373), Substrate Cathepsin G substrate (VWR, Calbiochem, cat. no. 219407). Cathepsin acti...


US Patent US9695194 (2017)


BindingDB Entry DOI: 10.7270/Q2CN723D
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM50014746
PNG
(3-({1-[2-(3-Methoxycarbonyl-propionylamino)-3-meth...)
Show SMILES COC(=O)CCC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)OC
Show InChI InChI=1S/C26H35N3O8/c1-16(2)22(28-20(30)12-13-21(31)36-3)25(34)29-14-8-11-19(29)24(33)27-18(23(32)26(35)37-4)15-17-9-6-5-7-10-17/h5-7,9-10,16,18-19,22H,8,11-15H2,1-4H3,(H,27,33)(H,28,30)/t18-,19-,22-/m0/s1
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1.10E+3n/an/an/an/an/an/an/an/a



Merrell Dow Research Institute

Curated by ChEMBL


Assay Description
Binding affinity against human Cathepsin G


J Med Chem 33: 394-407 (1990)


Article DOI: 10.1021/jm00163a063
BindingDB Entry DOI: 10.7270/Q26D5RZ5
More data for this
Ligand-Target Pair
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