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Compile Data Set for Download or QSAR

Found 70 hits Enz. Inhib. hit(s) with Target = 'Chemokine-like receptor 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517133
PNG
(CHEMBL4448632)
Show SMILES CCCCN([C@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(ccc2o1)C(=O)NC
Show InChI InChI=1S/C28H29N7O2/c1-4-5-16-35(28-30-24-17-21(27(36)29-3)14-15-25(24)37-28)18(2)19-10-12-20(13-11-19)22-8-6-7-9-23(22)26-31-33-34-32-26/h6-15,17-18H,4-5,16H2,1-3H3,(H,29,36)(H,31,32,33,34)/t18-/m1/s1
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n/an/an/an/a 280n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517152
PNG
(CHEMBL4527534)
Show SMILES CCCCN([C@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(NC(N)=O)ccc2o1
Show InChI InChI=1S/C27H28N8O2/c1-3-4-15-35(27-30-23-16-20(29-26(28)36)13-14-24(23)37-27)17(2)18-9-11-19(12-10-18)21-7-5-6-8-22(21)25-31-33-34-32-25/h5-14,16-17H,3-4,15H2,1-2H3,(H3,28,29,36)(H,31,32,33,34)/t17-/m1/s1
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n/an/an/an/a 430n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517131
PNG
(CHEMBL4472664)
Show SMILES CCCCN([C@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(NC(=O)N(C)C)ccc2o1
Show InChI InChI=1S/C29H32N8O2/c1-5-6-17-37(29-31-25-18-22(15-16-26(25)39-29)30-28(38)36(3)4)19(2)20-11-13-21(14-12-20)23-9-7-8-10-24(23)27-32-34-35-33-27/h7-16,18-19H,5-6,17H2,1-4H3,(H,30,38)(H,32,33,34,35)/t19-/m1/s1
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n/an/an/an/a 510n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517138
PNG
(CHEMBL4557657)
Show SMILES CCCCN([C@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(NC(=O)NC)ccc2o1
Show InChI InChI=1S/C28H30N8O2/c1-4-5-16-36(28-31-24-17-21(30-27(37)29-3)14-15-25(24)38-28)18(2)19-10-12-20(13-11-19)22-8-6-7-9-23(22)26-32-34-35-33-26/h6-15,17-18H,4-5,16H2,1-3H3,(H2,29,30,37)(H,32,33,34,35)/t18-/m1/s1
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n/an/an/an/a 940n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517151
PNG
(CHEMBL4467290)
Show SMILES CCCCN([C@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1
Show InChI InChI=1S/C26H26N6O/c1-3-4-17-32(26-27-23-11-7-8-12-24(23)33-26)18(2)19-13-15-20(16-14-19)21-9-5-6-10-22(21)25-28-30-31-29-25/h5-16,18H,3-4,17H2,1-2H3,(H,28,29,30,31)/t18-/m1/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517147
PNG
(CHEMBL4575422)
Show SMILES CCCCN([C@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(CNC(=O)NC)ccc2o1
Show InChI InChI=1S/C29H32N8O2/c1-4-5-16-37(29-32-25-17-20(10-15-26(25)39-29)18-31-28(38)30-3)19(2)21-11-13-22(14-12-21)23-8-6-7-9-24(23)27-33-35-36-34-27/h6-15,17,19H,4-5,16,18H2,1-3H3,(H2,30,31,38)(H,33,34,35,36)/t19-/m1/s1
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n/an/an/an/a 1.30E+3n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517130
PNG
(CHEMBL4476788)
Show SMILES CCCCN([C@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(NC(C)=O)ccc2o1
Show InChI InChI=1S/C28H29N7O2/c1-4-5-16-35(28-30-25-17-22(29-19(3)36)14-15-26(25)37-28)18(2)20-10-12-21(13-11-20)23-8-6-7-9-24(23)27-31-33-34-32-27/h6-15,17-18H,4-5,16H2,1-3H3,(H,29,36)(H,31,32,33,34)/t18-/m1/s1
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n/an/an/an/a 1.50E+3n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517128
PNG
(CHEMBL4448308)
Show SMILES CCCCN([C@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(CC(=O)NC)ccc2o1
Show InChI InChI=1S/C29H31N7O2/c1-4-5-16-36(29-31-25-17-20(18-27(37)30-3)10-15-26(25)38-29)19(2)21-11-13-22(14-12-21)23-8-6-7-9-24(23)28-32-34-35-33-28/h6-15,17,19H,4-5,16,18H2,1-3H3,(H,30,37)(H,32,33,34,35)/t19-/m1/s1
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n/an/an/an/a 2.30E+3n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517126
PNG
(CHEMBL4463797)
Show SMILES CCCCN(C(C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1
Show InChI InChI=1S/C26H26N6O/c1-3-4-17-32(26-27-23-11-7-8-12-24(23)33-26)18(2)19-13-15-20(16-14-19)21-9-5-6-10-22(21)25-28-30-31-29-25/h5-16,18H,3-4,17H2,1-2H3,(H,28,29,30,31)
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n/an/an/an/a 2.70E+3n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517146
PNG
(CHEMBL4561076)
Show SMILES CCCCN(C(C1CC1)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1
Show InChI InChI=1S/C28H28N6O/c1-2-3-18-34(28-29-24-10-6-7-11-25(24)35-28)26(21-16-17-21)20-14-12-19(13-15-20)22-8-4-5-9-23(22)27-30-32-33-31-27/h4-15,21,26H,2-3,16-18H2,1H3,(H,30,31,32,33)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517150
PNG
(CHEMBL4538515)
Show SMILES CCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(CC(=O)NC)ccc2o1
Show InChI InChI=1S/C28H29N7O2/c1-3-4-15-35(28-30-24-16-20(17-26(36)29-2)11-14-25(24)37-28)18-19-9-12-21(13-10-19)22-7-5-6-8-23(22)27-31-33-34-32-27/h5-14,16H,3-4,15,17-18H2,1-2H3,(H,29,36)(H,31,32,33,34)
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n/an/an/an/a 3.90E+3n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517125
PNG
(CHEMBL4474605)
Show SMILES CCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(C)ccc2o1
Show InChI InChI=1S/C26H26N6O/c1-3-4-15-32(26-27-23-16-18(2)9-14-24(23)33-26)17-19-10-12-20(13-11-19)21-7-5-6-8-22(21)25-28-30-31-29-25/h5-14,16H,3-4,15,17H2,1-2H3,(H,28,29,30,31)
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n/an/an/an/a 3.90E+3n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517135
PNG
(CHEMBL4472121)
Show SMILES CCCCN(C(CC)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1
Show InChI InChI=1S/C27H28N6O/c1-3-5-18-33(27-28-23-12-8-9-13-25(23)34-27)24(4-2)20-16-14-19(15-17-20)21-10-6-7-11-22(21)26-29-31-32-30-26/h6-17,24H,3-5,18H2,1-2H3,(H,29,30,31,32)
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n/an/an/an/a 4.50E+3n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517134
PNG
(CHEMBL4446260)
Show SMILES CCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1
Show InChI InChI=1S/C25H24N6O/c1-2-3-16-31(25-26-22-10-6-7-11-23(22)32-25)17-18-12-14-19(15-13-18)20-8-4-5-9-21(20)24-27-29-30-28-24/h4-15H,2-3,16-17H2,1H3,(H,27,28,29,30)
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n/an/an/an/a 5.20E+3n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517140
PNG
(CHEMBL4476545)
Show SMILES CCCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1
Show InChI InChI=1S/C26H26N6O/c1-2-3-8-17-32(26-27-23-11-6-7-12-24(23)33-26)18-19-13-15-20(16-14-19)21-9-4-5-10-22(21)25-28-30-31-29-25/h4-7,9-16H,2-3,8,17-18H2,1H3,(H,28,29,30,31)
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n/an/an/an/a 6.60E+3n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517148
PNG
(CHEMBL4593522)
Show SMILES C(C1CCCC1)N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1
Show InChI InChI=1S/C27H26N6O/c1-2-8-19(7-1)17-33(27-28-24-11-5-6-12-25(24)34-27)18-20-13-15-21(16-14-20)22-9-3-4-10-23(22)26-29-31-32-30-26/h3-6,9-16,19H,1-2,7-8,17-18H2,(H,29,30,31,32)
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n/an/an/an/a 8.30E+3n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
Chemokine-like receptor 1


(Homo sapiens (Human))
BDBM50255479
PNG
(CHEMBL4067429)
Show SMILES CC1=CCC[C@H]1NC(=O)Nc1ccc(Cl)c(c1O)S(=O)(=O)[C@@]1(C)CCOC1
Show InChI InChI=1S/C18H23ClN2O5S/c1-11-4-3-5-13(11)20-17(23)21-14-7-6-12(19)16(15(14)22)27(24,25)18(2)8-9-26-10-18/h4,6-7,13,22H,3,5,8-10H2,1-2H3,(H2,20,21,23)/t13-,18+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



GSK Pharmaceuticals R & D

Curated by ChEMBL


Assay Description
Agonist activity at CMKLR1 (unknown origin)


J Med Chem 61: 2518-2532 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01854
BindingDB Entry DOI: 10.7270/Q2959M1F
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517129
PNG
(CHEMBL4539132)
Show SMILES COCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1
Show InChI InChI=1S/C24H22N6O2/c1-31-15-14-30(24-25-21-8-4-5-9-22(21)32-24)16-17-10-12-18(13-11-17)19-6-2-3-7-20(19)23-26-28-29-27-23/h2-13H,14-16H2,1H3,(H,26,27,28,29)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517127
PNG
(CHEMBL4522836)
Show SMILES CCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(CC(=O)OC)ccc2o1
Show InChI InChI=1S/C28H28N6O3/c1-3-4-15-34(28-29-24-16-20(17-26(35)36-2)11-14-25(24)37-28)18-19-9-12-21(13-10-19)22-7-5-6-8-23(22)27-30-32-33-31-27/h5-14,16H,3-4,15,17-18H2,1-2H3,(H,30,31,32,33)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517136
PNG
(CHEMBL4442745)
Show SMILES CCCCN(c1nc2ccccc2o1)C(C)(C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C27H28N6O/c1-4-5-18-33(26-28-23-12-8-9-13-24(23)34-26)27(2,3)20-16-14-19(15-17-20)21-10-6-7-11-22(21)25-29-31-32-30-25/h6-17H,4-5,18H2,1-3H3,(H,29,30,31,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517132
PNG
(CHEMBL4458521)
Show SMILES C(N(Cc1ccccn1)c1nc2ccccc2o1)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C27H21N7O/c1-2-9-23(26-30-32-33-31-26)22(8-1)20-14-12-19(13-15-20)17-34(18-21-7-5-6-16-28-21)27-29-24-10-3-4-11-25(24)35-27/h1-16H,17-18H2,(H,30,31,32,33)
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Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517142
PNG
(CHEMBL4566228)
Show SMILES C(N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1)c1ccncc1
Show InChI InChI=1S/C27H21N7O/c1-2-6-23(26-30-32-33-31-26)22(5-1)21-11-9-19(10-12-21)17-34(18-20-13-15-28-16-14-20)27-29-24-7-3-4-8-25(24)35-27/h1-16H,17-18H2,(H,30,31,32,33)
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Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517143
PNG
(CHEMBL4549880)
Show SMILES CCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(Cl)c(C)cc2o1
Show InChI InChI=1S/C26H25ClN6O/c1-3-4-13-33(26-28-23-15-22(27)17(2)14-24(23)34-26)16-18-9-11-19(12-10-18)20-7-5-6-8-21(20)25-29-31-32-30-25/h5-12,14-15H,3-4,13,16H2,1-2H3,(H,29,30,31,32)
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Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517144
PNG
(CHEMBL4586253)
Show SMILES CCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(Cl)cc(C)c2o1
Show InChI InChI=1S/C26H25ClN6O/c1-3-4-13-33(26-28-23-15-20(27)14-17(2)24(23)34-26)16-18-9-11-19(12-10-18)21-7-5-6-8-22(21)25-29-31-32-30-25/h5-12,14-15H,3-4,13,16H2,1-2H3,(H,29,30,31,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517145
PNG
(CHEMBL4578235)
Show SMILES CCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(ccc2o1)C(=O)OC
Show InChI InChI=1S/C27H26N6O3/c1-3-4-15-33(27-28-23-16-20(26(34)35-2)13-14-24(23)36-27)17-18-9-11-19(12-10-18)21-7-5-6-8-22(21)25-29-31-32-30-25/h5-14,16H,3-4,15,17H2,1-2H3,(H,29,30,31,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517137
PNG
(CHEMBL4457246)
Show SMILES CCCCN([C@@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1
Show InChI InChI=1S/C26H26N6O/c1-3-4-17-32(26-27-23-11-7-8-12-24(23)33-26)18(2)19-13-15-20(16-14-19)21-9-5-6-10-22(21)25-28-30-31-29-25/h5-16,18H,3-4,17H2,1-2H3,(H,28,29,30,31)/t18-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517153
PNG
(CHEMBL4534314)
Show SMILES C(N(Cc1cccnc1)c1nc2ccccc2o1)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C27H21N7O/c1-2-8-23(26-30-32-33-31-26)22(7-1)21-13-11-19(12-14-21)17-34(18-20-6-5-15-28-16-20)27-29-24-9-3-4-10-25(24)35-27/h1-16H,17-18H2,(H,30,31,32,33)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517149
PNG
(CHEMBL4447627)
Show SMILES CCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(Cl)cc(Cl)c2o1
Show InChI InChI=1S/C25H22Cl2N6O/c1-2-3-12-33(25-28-22-14-18(26)13-21(27)23(22)34-25)15-16-8-10-17(11-9-16)19-6-4-5-7-20(19)24-29-31-32-30-24/h4-11,13-14H,2-3,12,15H2,1H3,(H,29,30,31,32)
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Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517141
PNG
(CHEMBL4552485)
Show SMILES C(N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1)c1ccccc1
Show InChI InChI=1S/C28H22N6O/c1-2-8-20(9-3-1)18-34(28-29-25-12-6-7-13-26(25)35-28)19-21-14-16-22(17-15-21)23-10-4-5-11-24(23)27-30-32-33-31-27/h1-17H,18-19H2,(H,30,31,32,33)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
Chemokine-like receptor 1


(Homo sapiens (Human))
BDBM50044849
PNG
(CHEMBL3311308)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H19NO3S/c1-11-9-12(2)16(13(3)10-11)17-21(18,19)15-7-5-14(20-4)6-8-15/h5-10,17H,1-4H3
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n/an/an/an/a<2.51E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CMKLR1 assessed as melanophore absorbance by summary (Abse5) assay


Bioorg Med Chem Lett 24: 3100-3 (2014)


Article DOI: 10.1016/j.bmcl.2014.05.012
BindingDB Entry DOI: 10.7270/Q2CC1292
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517125
PNG
(CHEMBL4474605)
Show SMILES CCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(C)ccc2o1
Show InChI InChI=1S/C26H26N6O/c1-3-4-15-32(26-27-23-16-18(2)9-14-24(23)33-26)17-19-10-12-20(13-11-19)21-7-5-6-8-22(21)25-28-30-31-29-25/h5-14,16H,3-4,15,17H2,1-2H3,(H,28,29,30,31)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517130
PNG
(CHEMBL4476788)
Show SMILES CCCCN([C@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(NC(C)=O)ccc2o1
Show InChI InChI=1S/C28H29N7O2/c1-4-5-16-35(28-30-25-17-22(29-19(3)36)14-15-26(25)37-28)18(2)20-10-12-21(13-11-20)23-8-6-7-9-24(23)27-31-33-34-32-27/h6-15,17-18H,4-5,16H2,1-3H3,(H,29,36)(H,31,32,33,34)/t18-/m1/s1
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n/an/a 440n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517133
PNG
(CHEMBL4448632)
Show SMILES CCCCN([C@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(ccc2o1)C(=O)NC
Show InChI InChI=1S/C28H29N7O2/c1-4-5-16-35(28-30-24-17-21(27(36)29-3)14-15-25(24)37-28)18(2)19-10-12-20(13-11-19)22-8-6-7-9-23(22)26-31-33-34-32-26/h6-15,17-18H,4-5,16H2,1-3H3,(H,29,36)(H,31,32,33,34)/t18-/m1/s1
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Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based C...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517134
PNG
(CHEMBL4446260)
Show SMILES CCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1
Show InChI InChI=1S/C25H24N6O/c1-2-3-16-31(25-26-22-10-6-7-11-23(22)32-25)17-18-12-14-19(15-13-18)20-8-4-5-9-21(20)24-27-29-30-28-24/h4-15H,2-3,16-17H2,1H3,(H,27,28,29,30)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517126
PNG
(CHEMBL4463797)
Show SMILES CCCCN(C(C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1
Show InChI InChI=1S/C26H26N6O/c1-3-4-17-32(26-27-23-11-7-8-12-24(23)33-26)18(2)19-13-15-20(16-14-19)21-9-5-6-10-22(21)25-28-30-31-29-25/h5-16,18H,3-4,17H2,1-2H3,(H,28,29,30,31)
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Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517135
PNG
(CHEMBL4472121)
Show SMILES CCCCN(C(CC)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1
Show InChI InChI=1S/C27H28N6O/c1-3-5-18-33(27-28-23-12-8-9-13-25(23)34-27)24(4-2)20-16-14-19(15-17-20)21-10-6-7-11-22(21)26-29-31-32-30-26/h6-17,24H,3-5,18H2,1-2H3,(H,29,30,31,32)
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n/an/a 940n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517136
PNG
(CHEMBL4442745)
Show SMILES CCCCN(c1nc2ccccc2o1)C(C)(C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C27H28N6O/c1-4-5-18-33(26-28-23-12-8-9-13-24(23)34-26)27(2,3)20-16-14-19(15-17-20)21-10-6-7-11-22(21)25-29-31-32-30-25/h6-17H,4-5,18H2,1-3H3,(H,29,30,31,32)
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n/an/a 8.40E+3n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517137
PNG
(CHEMBL4457246)
Show SMILES CCCCN([C@@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1
Show InChI InChI=1S/C26H26N6O/c1-3-4-17-32(26-27-23-11-7-8-12-24(23)33-26)18(2)19-13-15-20(16-14-19)21-9-5-6-10-22(21)25-28-30-31-29-25/h5-16,18H,3-4,17H2,1-2H3,(H,28,29,30,31)/t18-/m0/s1
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n/an/a 7.60E+3n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517128
PNG
(CHEMBL4448308)
Show SMILES CCCCN([C@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(CC(=O)NC)ccc2o1
Show InChI InChI=1S/C29H31N7O2/c1-4-5-16-36(29-31-25-17-20(18-27(37)30-3)10-15-26(25)38-29)19(2)21-11-13-22(14-12-21)23-8-6-7-9-24(23)28-32-34-35-33-28/h6-15,17,19H,4-5,16,18H2,1-3H3,(H,30,37)(H,32,33,34,35)/t19-/m1/s1
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n/an/a 120n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517138
PNG
(CHEMBL4557657)
Show SMILES CCCCN([C@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(NC(=O)NC)ccc2o1
Show InChI InChI=1S/C28H30N8O2/c1-4-5-16-36(28-31-24-17-21(30-27(37)29-3)14-15-25(24)38-28)18(2)19-10-12-20(13-11-19)22-8-6-7-9-23(22)26-32-34-35-33-26/h6-15,17-18H,4-5,16H2,1-3H3,(H2,29,30,37)(H,32,33,34,35)/t18-/m1/s1
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n/an/a 34n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517131
PNG
(CHEMBL4472664)
Show SMILES CCCCN([C@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(NC(=O)N(C)C)ccc2o1
Show InChI InChI=1S/C29H32N8O2/c1-5-6-17-37(29-31-25-18-22(15-16-26(25)39-29)30-28(38)36(3)4)19(2)20-11-13-21(14-12-20)23-9-7-8-10-24(23)27-32-34-35-33-27/h7-16,18-19H,5-6,17H2,1-4H3,(H,30,38)(H,32,33,34,35)/t19-/m1/s1
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n/an/a 32n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517139
PNG
(CHEMBL4449507)
Show SMILES CCCCN([C@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(ccc2o1)N(C)C(N)=O
Show InChI InChI=1S/C28H30N8O2/c1-4-5-16-36(28-30-24-17-21(35(3)27(29)37)14-15-25(24)38-28)18(2)19-10-12-20(13-11-19)22-8-6-7-9-23(22)26-31-33-34-32-26/h6-15,17-18H,4-5,16H2,1-3H3,(H2,29,37)(H,31,32,33,34)/t18-/m1/s1
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n/an/a>3.00E+3n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517133
PNG
(CHEMBL4448632)
Show SMILES CCCCN([C@H](C)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(ccc2o1)C(=O)NC
Show InChI InChI=1S/C28H29N7O2/c1-4-5-16-35(28-30-24-17-21(27(36)29-3)14-15-25(24)37-28)18(2)19-10-12-20(13-11-19)22-8-6-7-9-23(22)26-31-33-34-32-26/h6-15,17-18H,4-5,16H2,1-3H3,(H,29,36)(H,31,32,33,34)/t18-/m1/s1
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n/an/a 38n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517140
PNG
(CHEMBL4476545)
Show SMILES CCCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1
Show InChI InChI=1S/C26H26N6O/c1-2-3-8-17-32(26-27-23-11-6-7-12-24(23)33-26)18-19-13-15-20(16-14-19)21-9-4-5-10-22(21)25-28-30-31-29-25/h4-7,9-16H,2-3,8,17-18H2,1H3,(H,28,29,30,31)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517141
PNG
(CHEMBL4552485)
Show SMILES C(N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1)c1ccccc1
Show InChI InChI=1S/C28H22N6O/c1-2-8-20(9-3-1)18-34(28-29-25-12-6-7-13-26(25)35-28)19-21-14-16-22(17-15-21)23-10-4-5-11-24(23)27-30-32-33-31-27/h1-17H,18-19H2,(H,30,31,32,33)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517132
PNG
(CHEMBL4458521)
Show SMILES C(N(Cc1ccccn1)c1nc2ccccc2o1)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C27H21N7O/c1-2-9-23(26-30-32-33-31-26)22(8-1)20-14-12-19(13-15-20)17-34(18-21-7-5-6-16-28-21)27-29-24-10-3-4-11-25(24)35-27/h1-16H,17-18H2,(H,30,31,32,33)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517142
PNG
(CHEMBL4566228)
Show SMILES C(N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2ccccc2o1)c1ccncc1
Show InChI InChI=1S/C27H21N7O/c1-2-6-23(26-30-32-33-31-26)22(5-1)21-11-9-19(10-12-21)17-34(18-20-13-15-28-16-14-20)27-29-24-7-3-4-8-25(24)35-27/h1-16H,17-18H2,(H,30,31,32,33)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517143
PNG
(CHEMBL4549880)
Show SMILES CCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(Cl)c(C)cc2o1
Show InChI InChI=1S/C26H25ClN6O/c1-3-4-13-33(26-28-23-15-22(27)17(2)14-24(23)34-26)16-18-9-11-19(12-10-18)20-7-5-6-8-21(20)25-29-31-32-30-25/h5-12,14-15H,3-4,13,16H2,1-2H3,(H,29,30,31,32)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517144
PNG
(CHEMBL4586253)
Show SMILES CCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(Cl)cc(C)c2o1
Show InChI InChI=1S/C26H25ClN6O/c1-3-4-13-33(26-28-23-15-20(27)14-17(2)24(23)34-26)16-18-9-11-19(12-10-18)21-7-5-6-8-22(21)25-29-31-32-30-25/h5-12,14-15H,3-4,13,16H2,1-2H3,(H,29,30,31,32)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
G-protein coupled receptor ChemR23


(Homo sapiens (Human))
BDBM50517145
PNG
(CHEMBL4578235)
Show SMILES CCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc2cc(ccc2o1)C(=O)OC
Show InChI InChI=1S/C27H26N6O3/c1-3-4-15-33(27-28-23-16-20(26(34)35-2)13-14-24(23)36-27)17-18-9-11-19(12-10-18)21-7-5-6-8-22(21)25-29-31-32-30-25/h5-14,16H,3-4,15,17H2,1-2H3,(H,29,30,31,32)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Kyowa Kirin Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115091
More data for this
Ligand-Target Pair
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