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Compile Data Set for Download or QSAR

Found 260 hits Enz. Inhib. hit(s) with Target = 'Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50400564
PNG
(CHEMBL2206242)
Show SMILES CCCn1cnc2c(NCc3ccc(C)s3)nc(N[C@H](CC)CO)nc12
Show InChI InChI=1S/C18H26N6OS/c1-4-8-24-11-20-15-16(19-9-14-7-6-12(3)26-14)22-18(23-17(15)24)21-13(5-2)10-25/h6-7,11,13,25H,4-5,8-10H2,1-3H3,(H2,19,21,22,23)/t13-/m1/s1
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n/an/an/an/a 2.06E+4n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human Cdk1/cyclin B activity


ACS Med Chem Lett 3: 985-990 (2012)


Article DOI: 10.1021/ml3002083
BindingDB Entry DOI: 10.7270/Q2BC40P0
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50395892
PNG
(CHEMBL2163772)
Show SMILES Oc1ccc2oc3ncc(O)c(-c4ccccc4)c3c2c1
Show InChI InChI=1S/C17H11NO3/c19-11-6-7-14-12(8-11)16-15(10-4-2-1-3-5-10)13(20)9-18-17(16)21-14/h1-9,19-20H
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10n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK1/Cyclin B


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50395887
PNG
(CHEMBL2163770)
Show SMILES Oc1cc2c(oc3ncc(OCc4ccccc4)c(-c4ccccc4)c23)c2ccccc12
Show InChI InChI=1S/C28H19NO3/c30-23-15-22-26-25(19-11-5-2-6-12-19)24(31-17-18-9-3-1-4-10-18)16-29-28(26)32-27(22)21-14-8-7-13-20(21)23/h1-16,30H,17H2
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90n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK1/Cyclin B


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50395894
PNG
(CHEMBL2163771)
Show SMILES Oc1cnc2oc3c(cc(O)c4ccccc34)c2c1-c1ccccc1
Show InChI InChI=1S/C21H13NO3/c23-16-10-15-19-18(12-6-2-1-3-7-12)17(24)11-22-21(19)25-20(15)14-9-5-4-8-13(14)16/h1-11,23-24H
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700n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK1/Cyclin B


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50395888
PNG
(CHEMBL2163769)
Show SMILES Cc1cc2oc3ncc(OCc4ccccc4)c(-c4ccccc4)c3c2cc1O
Show InChI InChI=1S/C25H19NO3/c1-16-12-21-19(13-20(16)27)24-23(18-10-6-3-7-11-18)22(14-26-25(24)29-21)28-15-17-8-4-2-5-9-17/h2-14,27H,15H2,1H3
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1.30E+3n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK1/Cyclin B


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50395893
PNG
(CHEMBL1165662)
Show SMILES Oc1ccc2oc3ncc(OCc4ccccc4)c(-c4ccccc4)c3c2c1
Show InChI InChI=1S/C24H17NO3/c26-18-11-12-20-19(13-18)23-22(17-9-5-2-6-10-17)21(14-25-24(23)28-20)27-15-16-7-3-1-4-8-16/h1-14,26H,15H2
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2.30E+3n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK1/Cyclin B


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM7453
PNG
(1-aza-9-oxafluorene deriv. 7b | 4-methoxy-3-phenyl...)
Show SMILES COc1cnc2oc3ccc(O)cc3c2c1-c1ccccc1
Show InChI InChI=1S/C18H13NO3/c1-21-15-10-19-18-17(16(15)11-5-3-2-4-6-11)13-9-12(20)7-8-14(13)22-18/h2-10,20H,1H3
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5.30E+3n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK1/Cyclin B


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50395890
PNG
(CHEMBL2163774)
Show SMILES COc1ccc2oc3ncc(OCc4ccccc4)c(-c4ccccc4)c3c2c1
Show InChI InChI=1S/C25H19NO3/c1-27-19-12-13-21-20(14-19)24-23(18-10-6-3-7-11-18)22(15-26-25(24)29-21)28-16-17-8-4-2-5-9-17/h2-15H,16H2,1H3
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>1.00E+6n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK1/Cyclin B


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50395891
PNG
(CHEMBL2163773)
Show SMILES COc1ccc2oc3ncc(OC)c(-c4ccccc4)c3c2c1
Show InChI InChI=1S/C19H15NO3/c1-21-13-8-9-15-14(10-13)18-17(12-6-4-3-5-7-12)16(22-2)11-20-19(18)23-15/h3-11H,1-2H3
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>1.00E+6n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK1/Cyclin B


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50395889
PNG
(CHEMBL2163768)
Show SMILES COc1ccc2oc3ncc(O)c(-c4ccccc4)c3c2c1
Show InChI InChI=1S/C18H13NO3/c1-21-12-7-8-15-13(9-12)17-16(11-5-3-2-4-6-11)14(20)10-19-18(17)22-15/h2-10,20H,1H3
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>1.00E+6n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK1/Cyclin B


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM10641
PNG
(6-(benzylamino)-9-isopropylpurine | CHEMBL85015 | ...)
Show SMILES CC(C)n1cnc2c(NCc3ccccc3)ncnc12
Show InChI InChI=1S/C15H17N5/c1-11(2)20-10-19-13-14(17-9-18-15(13)20)16-8-12-6-4-3-5-7-12/h3-7,9-11H,8H2,1-2H3,(H,16,17,18)
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n/an/a 3.60n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132177
PNG
(3-[(9-Isopropyl-9H-purin-6-ylamino)-methyl]-phenol...)
Show SMILES CC(C)n1cnc2c(NCc3cccc(O)c3)ncnc12
Show InChI InChI=1S/C15H17N5O/c1-10(2)20-9-19-13-14(17-8-18-15(13)20)16-7-11-4-3-5-12(21)6-11/h3-6,8-10,21H,7H2,1-2H3,(H,16,17,18)
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n/an/a 3.10n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132176
PNG
((9-Isopropyl-9H-purin-6-yl)-(4-methoxy-benzyl)-ami...)
Show SMILES COc1ccc(CNc2ncnc3n(cnc23)C(C)C)cc1
Show InChI InChI=1S/C16H19N5O/c1-11(2)21-10-20-14-15(18-9-19-16(14)21)17-8-12-4-6-13(22-3)7-5-12/h4-7,9-11H,8H2,1-3H3,(H,17,18,19)
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n/an/a 3.80n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132169
PNG
((3-Chloro-phenyl)-(3-isopropyl-1H-pyrazolo[4,3-d]p...)
Show SMILES CC(C)c1[nH]nc2c(Nc3cccc(Cl)c3)ncnc12
Show InChI InChI=1S/C14H14ClN5/c1-8(2)11-12-13(20-19-11)14(17-7-16-12)18-10-5-3-4-9(15)6-10/h3-8H,1-2H3,(H,19,20)(H,16,17,18)
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n/an/a 0.900n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132179
PNG
(4-[(3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylam...)
Show SMILES CC(C)c1[nH]nc2c(NCc3ccc(O)cc3)ncnc12
Show InChI InChI=1S/C15H17N5O/c1-9(2)12-13-14(20-19-12)15(18-8-17-13)16-7-10-3-5-11(21)6-4-10/h3-6,8-9,21H,7H2,1-2H3,(H,19,20)(H,16,17,18)
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n/an/a 1.80n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132186
PNG
(5-[(9-Isopropyl-9H-purin-6-ylamino)-methyl]-2-meth...)
Show SMILES COc1ccc(CNc2ncnc3n(cnc23)C(C)C)cc1O
Show InChI InChI=1S/C16H19N5O2/c1-10(2)21-9-20-14-15(18-8-19-16(14)21)17-7-11-4-5-13(23-3)12(22)6-11/h4-6,8-10,22H,7H2,1-3H3,(H,17,18,19)
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n/an/a 4.5n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132178
PNG
(5-[(3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylam...)
Show SMILES COc1ccc(CNc2ncnc3c([nH]nc23)C(C)C)cc1O
Show InChI InChI=1S/C16H19N5O2/c1-9(2)13-14-15(21-20-13)16(19-8-18-14)17-7-10-4-5-12(23-3)11(22)6-10/h4-6,8-9,22H,7H2,1-3H3,(H,20,21)(H,17,18,19)
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n/an/a 1.10n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132176
PNG
((9-Isopropyl-9H-purin-6-yl)-(4-methoxy-benzyl)-ami...)
Show SMILES COc1ccc(CNc2ncnc3n(cnc23)C(C)C)cc1
Show InChI InChI=1S/C16H19N5O/c1-11(2)21-10-20-14-15(18-9-19-16(14)21)17-8-12-4-6-13(22-3)7-5-12/h4-7,9-11H,8H2,1-3H3,(H,17,18,19)
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n/an/a>167n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132183
PNG
((3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-pen...)
Show SMILES CCCCCNc1ncnc2c([nH]nc12)C(C)C
Show InChI InChI=1S/C13H21N5/c1-4-5-6-7-14-13-12-11(15-8-16-13)10(9(2)3)17-18-12/h8-9H,4-7H2,1-3H3,(H,17,18)(H,14,15,16)
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n/an/a 1.20n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132181
PNG
((2-Bromo-benzyl)-(9-isopropyl-9H-purin-6-yl)-amine...)
Show SMILES CC(C)n1cnc2c(NCc3ccccc3Br)ncnc12
Show InChI InChI=1S/C15H16BrN5/c1-10(2)21-9-20-13-14(18-8-19-15(13)21)17-7-11-5-3-4-6-12(11)16/h3-6,8-10H,7H2,1-2H3,(H,17,18,19)
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n/an/a 23n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM5718
PNG
(2,6,9-Trisubstituted purine deriv. 26 | 2-{[6-(ben...)
Show SMILES Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12
Show InChI InChI=1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)
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n/an/a 7n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132182
PNG
((9-Isopropyl-9H-purin-6-yl)-pentyl-amine | CHEMBL9...)
Show SMILES CCCCCNc1ncnc2n(cnc12)C(C)C
Show InChI InChI=1S/C13H21N5/c1-4-5-6-7-14-12-11-13(16-8-15-12)18(9-17-11)10(2)3/h8-10H,4-7H2,1-3H3,(H,14,15,16)
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n/an/a 6.90n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132172
PNG
(3-[(3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylam...)
Show SMILES CC(C)c1[nH]nc2c(NCc3cccc(O)c3)ncnc12
Show InChI InChI=1S/C15H17N5O/c1-9(2)12-13-14(20-19-12)15(18-8-17-13)16-7-10-4-3-5-11(21)6-10/h3-6,8-9,21H,7H2,1-2H3,(H,19,20)(H,16,17,18)
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n/an/a 1.70n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132171
PNG
(4-[(9-Isopropyl-9H-purin-6-ylamino)-methyl]-phenol...)
Show SMILES CC(C)n1cnc2c(NCc3ccc(O)cc3)ncnc12
Show InChI InChI=1S/C15H17N5O/c1-10(2)20-9-19-13-14(17-8-18-15(13)20)16-7-11-3-5-12(21)6-4-11/h3-6,8-10,21H,7H2,1-2H3,(H,16,17,18)
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n/an/a 4n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132175
PNG
(2-[(3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylam...)
Show SMILES CC(C)c1[nH]nc2c(NCc3ccccc3O)ncnc12
Show InChI InChI=1S/C15H17N5O/c1-9(2)12-13-14(20-19-12)15(18-8-17-13)16-7-10-5-3-4-6-11(10)21/h3-6,8-9,21H,7H2,1-2H3,(H,19,20)(H,16,17,18)
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n/an/a 0.440n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132171
PNG
(4-[(9-Isopropyl-9H-purin-6-ylamino)-methyl]-phenol...)
Show SMILES CC(C)n1cnc2c(NCc3ccc(O)cc3)ncnc12
Show InChI InChI=1S/C15H17N5O/c1-10(2)20-9-19-13-14(17-8-18-15(13)20)16-7-11-3-5-12(21)6-4-11/h3-6,8-10,21H,7H2,1-2H3,(H,16,17,18)
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n/an/a>167n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132175
PNG
(2-[(3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylam...)
Show SMILES CC(C)c1[nH]nc2c(NCc3ccccc3O)ncnc12
Show InChI InChI=1S/C15H17N5O/c1-9(2)12-13-14(20-19-12)15(18-8-17-13)16-7-10-5-3-4-6-11(10)21/h3-6,8-9,21H,7H2,1-2H3,(H,19,20)(H,16,17,18)
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n/an/a 54n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132172
PNG
(3-[(3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylam...)
Show SMILES CC(C)c1[nH]nc2c(NCc3cccc(O)c3)ncnc12
Show InChI InChI=1S/C15H17N5O/c1-9(2)12-13-14(20-19-12)15(18-8-17-13)16-7-10-4-3-5-11(21)6-10/h3-6,8-9,21H,7H2,1-2H3,(H,19,20)(H,16,17,18)
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n/an/a 88n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132181
PNG
((2-Bromo-benzyl)-(9-isopropyl-9H-purin-6-yl)-amine...)
Show SMILES CC(C)n1cnc2c(NCc3ccccc3Br)ncnc12
Show InChI InChI=1S/C15H16BrN5/c1-10(2)21-9-20-13-14(18-8-19-15(13)21)17-7-11-5-3-4-6-12(11)16/h3-6,8-10H,7H2,1-2H3,(H,17,18,19)
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n/an/a 49n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132169
PNG
((3-Chloro-phenyl)-(3-isopropyl-1H-pyrazolo[4,3-d]p...)
Show SMILES CC(C)c1[nH]nc2c(Nc3cccc(Cl)c3)ncnc12
Show InChI InChI=1S/C14H14ClN5/c1-8(2)11-12-13(20-19-11)14(17-7-16-12)18-10-5-3-4-9(15)6-10/h3-8H,1-2H3,(H,19,20)(H,16,17,18)
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n/an/a 18n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132178
PNG
(5-[(3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylam...)
Show SMILES COc1ccc(CNc2ncnc3c([nH]nc23)C(C)C)cc1O
Show InChI InChI=1S/C16H19N5O2/c1-9(2)13-14-15(21-20-13)16(19-8-18-14)17-7-10-4-5-12(23-3)11(22)6-10/h4-6,8-9,22H,7H2,1-3H3,(H,20,21)(H,17,18,19)
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n/an/a 26n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cyclin-dependent kinase 1-cyclin B


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132170
PNG
(2-[(9-Isopropyl-9H-purin-6-ylamino)-methyl]-phenol...)
Show SMILES CC(C)n1cnc2c(NCc3ccccc3O)ncnc12
Show InChI InChI=1S/C15H17N5O/c1-10(2)20-9-19-13-14(17-8-18-15(13)20)16-7-11-5-3-4-6-12(11)21/h3-6,8-10,21H,7H2,1-2H3,(H,16,17,18)
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n/an/a 4.40n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132180
PNG
((3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-(3-...)
Show SMILES CC(C)c1[nH]nc2c(NCC=C(C)C)ncnc12
Show InChI InChI=1S/C13H19N5/c1-8(2)5-6-14-13-12-11(15-7-16-13)10(9(3)4)17-18-12/h5,7,9H,6H2,1-4H3,(H,17,18)(H,14,15,16)
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n/an/a 4.5n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM10641
PNG
(6-(benzylamino)-9-isopropylpurine | CHEMBL85015 | ...)
Show SMILES CC(C)n1cnc2c(NCc3ccccc3)ncnc12
Show InChI InChI=1S/C15H17N5/c1-11(2)20-10-19-13-14(17-9-18-15(13)20)16-8-12-6-4-3-5-7-12/h3-7,9-11H,8H2,1-2H3,(H,16,17,18)
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n/an/a 113n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132170
PNG
(2-[(9-Isopropyl-9H-purin-6-ylamino)-methyl]-phenol...)
Show SMILES CC(C)n1cnc2c(NCc3ccccc3O)ncnc12
Show InChI InChI=1S/C15H17N5O/c1-10(2)20-9-19-13-14(17-8-18-15(13)20)16-7-11-5-3-4-6-12(11)21/h3-6,8-10,21H,7H2,1-2H3,(H,16,17,18)
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n/an/a 125n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132184
PNG
((9-Isopropyl-9H-purin-6-yl)-(3-methyl-but-2-enyl)-...)
Show SMILES CC(C)n1cnc2c(NCC=C(C)C)ncnc12
Show InChI InChI=1S/C13H19N5/c1-9(2)5-6-14-12-11-13(16-7-15-12)18(8-17-11)10(3)4/h5,7-8,10H,6H2,1-4H3,(H,14,15,16)
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n/an/a 17n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132168
PNG
(CHEMBL103798 | Furan-2-ylmethyl-(9-isopropyl-9H-pu...)
Show SMILES CC(C)n1cnc2c(NCc3ccco3)ncnc12
Show InChI InChI=1S/C13H15N5O/c1-9(2)18-8-17-11-12(15-7-16-13(11)18)14-6-10-4-3-5-19-10/h3-5,7-9H,6H2,1-2H3,(H,14,15,16)
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n/an/a 9.10n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132167
PNG
(CHEMBL103206 | Furan-2-ylmethyl-(3-isopropyl-1H-py...)
Show SMILES CC(C)c1[nH]nc2c(NCc3ccco3)ncnc12
Show InChI InChI=1S/C13H15N5O/c1-8(2)10-11-12(18-17-10)13(16-7-15-11)14-6-9-4-3-5-19-9/h3-5,7-8H,6H2,1-2H3,(H,17,18)(H,14,15,16)
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n/an/a 2.5n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132185
PNG
(Benzyl-(3-isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-...)
Show SMILES CC(C)c1[nH]nc2c(NCc3ccccc3)ncnc12
Show InChI InChI=1S/C15H17N5/c1-10(2)12-13-14(20-19-12)15(18-9-17-13)16-8-11-6-4-3-5-7-11/h3-7,9-10H,8H2,1-2H3,(H,19,20)(H,16,17,18)
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n/an/a 1.20n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132174
PNG
((3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-(4-...)
Show SMILES COc1ccc(CNc2ncnc3c([nH]nc23)C(C)C)cc1
Show InChI InChI=1S/C16H19N5O/c1-10(2)13-14-15(21-20-13)16(19-9-18-14)17-8-11-4-6-12(22-3)7-5-11/h4-7,9-10H,8H2,1-3H3,(H,20,21)(H,17,18,19)
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n/an/a 2.30n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132187
PNG
((2-Bromo-benzyl)-(3-isopropyl-1H-pyrazolo[4,3-d]py...)
Show SMILES CC(C)c1[nH]nc2c(NCc3ccccc3Br)ncnc12
Show InChI InChI=1S/C15H16BrN5/c1-9(2)12-13-14(21-20-12)15(19-8-18-13)17-7-10-5-3-4-6-11(10)16/h3-6,8-9H,7H2,1-2H3,(H,20,21)(H,17,18,19)
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n/an/a 11n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132180
PNG
((3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-(3-...)
Show SMILES CC(C)c1[nH]nc2c(NCC=C(C)C)ncnc12
Show InChI InChI=1S/C13H19N5/c1-8(2)5-6-14-13-12-11(15-7-16-13)10(9(3)4)17-18-12/h5,7,9H,6H2,1-4H3,(H,17,18)(H,14,15,16)
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n/an/a 152n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132184
PNG
((9-Isopropyl-9H-purin-6-yl)-(3-methyl-but-2-enyl)-...)
Show SMILES CC(C)n1cnc2c(NCC=C(C)C)ncnc12
Show InChI InChI=1S/C13H19N5/c1-9(2)5-6-14-12-11-13(16-7-15-12)18(8-17-11)10(3)4/h5,7-8,10H,6H2,1-4H3,(H,14,15,16)
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n/an/a>167n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132174
PNG
((3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-(4-...)
Show SMILES COc1ccc(CNc2ncnc3c([nH]nc23)C(C)C)cc1
Show InChI InChI=1S/C16H19N5O/c1-10(2)13-14-15(21-20-13)16(19-9-18-14)17-8-11-4-6-12(22-3)7-5-11/h4-7,9-10H,8H2,1-3H3,(H,20,21)(H,17,18,19)
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n/an/a 46n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132187
PNG
((2-Bromo-benzyl)-(3-isopropyl-1H-pyrazolo[4,3-d]py...)
Show SMILES CC(C)c1[nH]nc2c(NCc3ccccc3Br)ncnc12
Show InChI InChI=1S/C15H16BrN5/c1-9(2)12-13-14(21-20-12)15(19-8-18-13)17-7-10-5-3-4-6-11(10)16/h3-6,8-9H,7H2,1-2H3,(H,20,21)(H,17,18,19)
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n/an/a 29n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132173
PNG
((3-Chloro-phenyl)-(9-isopropyl-9H-purin-6-yl)-amin...)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)ncnc12
Show InChI InChI=1S/C14H14ClN5/c1-9(2)20-8-18-12-13(16-7-17-14(12)20)19-11-5-3-4-10(15)6-11/h3-9H,1-2H3,(H,16,17,19)
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n/an/a 5.90n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132168
PNG
(CHEMBL103798 | Furan-2-ylmethyl-(9-isopropyl-9H-pu...)
Show SMILES CC(C)n1cnc2c(NCc3ccco3)ncnc12
Show InChI InChI=1S/C13H15N5O/c1-9(2)18-8-17-11-12(15-7-16-13(11)18)14-6-10-4-3-5-19-10/h3-5,7-9H,6H2,1-2H3,(H,14,15,16)
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n/an/a>167n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132177
PNG
(3-[(9-Isopropyl-9H-purin-6-ylamino)-methyl]-phenol...)
Show SMILES CC(C)n1cnc2c(NCc3cccc(O)c3)ncnc12
Show InChI InChI=1S/C15H17N5O/c1-10(2)20-9-19-13-14(17-8-18-15(13)20)16-7-11-4-3-5-12(21)6-11/h3-6,8-10,21H,7H2,1-2H3,(H,16,17,18)
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n/an/a>167n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50132173
PNG
((3-Chloro-phenyl)-(9-isopropyl-9H-purin-6-yl)-amin...)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)ncnc12
Show InChI InChI=1S/C14H14ClN5/c1-9(2)20-8-18-12-13(16-7-17-14(12)20)19-11-5-3-4-10(15)6-11/h3-9H,1-2H3,(H,16,17,19)
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n/an/a 54n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM5718
PNG
(2,6,9-Trisubstituted purine deriv. 26 | 2-{[6-(ben...)
Show SMILES Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12
Show InChI InChI=1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)
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n/an/a 163n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
In vitro antiproliferative activity against myeloid leukemia K562 cell line


Bioorg Med Chem Lett 13: 2989-92 (2003)


Article DOI: 10.1016/s0960-894x(03)00631-0
BindingDB Entry DOI: 10.7270/Q29Z948Q
More data for this
Ligand-Target Pair
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