BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1586 hits Enz. Inhib. hit(s) with Target = 'Cyclin-Dependent Kinase 5 (CDK5)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50400564
PNG
(CHEMBL2206242)
Show SMILES CCCn1cnc2c(NCc3ccc(C)s3)nc(N[C@H](CC)CO)nc12
Show InChI InChI=1S/C18H26N6OS/c1-4-8-24-11-20-15-16(19-9-14-7-6-12(3)26-14)22-18(23-17(15)24)21-13(5-2)10-25/h6-7,11,13,25H,4-5,8-10H2,1-3H3,(H2,19,21,22,23)/t13-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.03E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human Cdk5/p35 activity


ACS Med Chem Lett 3: 985-990 (2012)


Article DOI: 10.1021/ml3002083
BindingDB Entry DOI: 10.7270/Q2BC40P0
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50113281
PNG
(AT-7519)
Show SMILES Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1
Show InChI InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
18n/an/an/an/an/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Inhibition of recombinant human full length N-terminal His6-tagged CDK5/N-terminal GST-tagged p25 expressed in baculovirus infected Sf21 insect cells...


J Med Chem 59: 8667-8684 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00150
BindingDB Entry DOI: 10.7270/Q2G73GP8
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50395894
PNG
(CHEMBL2163771)
Show SMILES Oc1cnc2oc3c(cc(O)c4ccccc34)c2c1-c1ccccc1
Show InChI InChI=1S/C21H13NO3/c23-16-10-15-19-18(12-6-2-1-3-7-12)17(24)11-22-21(19)25-20(15)14-9-5-4-8-13(14)16/h1-11,23-24H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
70n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK5/p25


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50395892
PNG
(CHEMBL2163772)
Show SMILES Oc1ccc2oc3ncc(O)c(-c4ccccc4)c3c2c1
Show InChI InChI=1S/C17H11NO3/c19-11-6-7-14-12(8-11)16-15(10-4-2-1-3-5-10)13(20)9-18-17(16)21-14/h1-9,19-20H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
110n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK5/p25


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50133557
PNG
(1-[2-(2,6-Dichloro-benzyl)-thiazol-4-yl]-3-morphol...)
Show SMILES Clc1cccc(Cl)c1Cc1nc(NC(=O)NN2CCOCC2)cs1
Show InChI InChI=1S/C15H16Cl2N4O2S/c16-11-2-1-3-12(17)10(11)8-14-18-13(9-24-14)19-15(22)20-21-4-6-23-7-5-21/h1-3,9H,4-8H2,(H2,19,20,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
500n/an/an/an/an/an/an/an/a



Pharmacia Corporation

Curated by ChEMBL


Assay Description
Inhibition of Tau Protein Kinase II (TPK II)


Bioorg Med Chem Lett 13: 3491-5 (2003)


Article DOI: 10.1016/s0960-894x(03)00726-1
BindingDB Entry DOI: 10.7270/Q2XG9QHN
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50395887
PNG
(CHEMBL2163770)
Show SMILES Oc1cc2c(oc3ncc(OCc4ccccc4)c(-c4ccccc4)c23)c2ccccc12
Show InChI InChI=1S/C28H19NO3/c30-23-15-22-26-25(19-11-5-2-6-12-19)24(31-17-18-9-3-1-4-10-18)16-29-28(26)32-27(22)21-14-8-7-13-20(21)23/h1-16,30H,17H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.10E+3n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK5/p25


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50395888
PNG
(CHEMBL2163769)
Show SMILES Cc1cc2oc3ncc(OCc4ccccc4)c(-c4ccccc4)c3c2cc1O
Show InChI InChI=1S/C25H19NO3/c1-16-12-21-19(13-20(16)27)24-23(18-10-6-3-7-11-18)22(14-26-25(24)29-21)28-15-17-8-4-2-5-9-17/h2-14,27H,15H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.53E+4n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK5/p25


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50395890
PNG
(CHEMBL2163774)
Show SMILES COc1ccc2oc3ncc(OCc4ccccc4)c(-c4ccccc4)c3c2c1
Show InChI InChI=1S/C25H19NO3/c1-27-19-12-13-21-20(14-19)24-23(18-10-6-3-7-11-18)22(15-26-25(24)29-21)28-16-17-8-4-2-5-9-17/h2-15H,16H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.61E+4n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK5/p25


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7453
PNG
(1-aza-9-oxafluorene deriv. 7b | 4-methoxy-3-phenyl...)
Show SMILES COc1cnc2oc3ccc(O)cc3c2c1-c1ccccc1
Show InChI InChI=1S/C18H13NO3/c1-21-15-10-19-18-17(16(15)11-5-3-2-4-6-11)13-9-12(20)7-8-14(13)22-18/h2-10,20H,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.17E+5n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK5/p25


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50395891
PNG
(CHEMBL2163773)
Show SMILES COc1ccc2oc3ncc(OC)c(-c4ccccc4)c3c2c1
Show InChI InChI=1S/C19H15NO3/c1-21-13-8-9-15-14(10-13)18-17(12-6-4-3-5-7-12)16(22-2)11-20-19(18)23-15/h3-11H,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+6n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK5/p25


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50395893
PNG
(CHEMBL1165662)
Show SMILES Oc1ccc2oc3ncc(OCc4ccccc4)c(-c4ccccc4)c3c2c1
Show InChI InChI=1S/C24H17NO3/c26-18-11-12-20-19(13-18)23-22(17-9-5-2-6-10-17)21(14-25-24(23)28-20)27-15-16-7-3-1-4-8-16/h1-14,26H,15H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+6n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK5/p25


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50331612
PNG
(CHEMBL1290072 | N-(4-methoxybenzyl)benzofuro[2,3-b...)
Show SMILES COc1ccc(CNc2ccnc3oc4ccccc4c23)cc1
Show InChI InChI=1S/C19H16N2O2/c1-22-14-8-6-13(7-9-14)12-21-16-10-11-20-19-18(16)15-4-2-3-5-17(15)23-19/h2-11H,12H2,1H3,(H,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+6n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of human CDK5/p25


Bioorg Med Chem Lett 20: 6915-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.004
BindingDB Entry DOI: 10.7270/Q2GF0TQS
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50395889
PNG
(CHEMBL2163768)
Show SMILES COc1ccc2oc3ncc(O)c(-c4ccccc4)c3c2c1
Show InChI InChI=1S/C18H13NO3/c1-21-12-7-8-15-13(9-12)17-16(11-5-3-2-4-6-11)14(20)10-19-18(17)22-15/h2-10,20H,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+6n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of CDK5/p25


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50431995
PNG
(CHEMBL2348725)
Show SMILES O=C(Nc1n[nH]c(=O)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C15H11N3O2/c19-14(10-6-2-1-3-7-10)16-13-11-8-4-5-9-12(11)15(20)18-17-13/h1-9H,(H,18,20)(H,16,17,19)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50431996
PNG
(CHEMBL2348724)
Show SMILES Nc1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C8H7N3O/c9-7-5-3-1-2-4-6(5)8(12)11-10-7/h1-4H,(H2,9,10)(H,11,12)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50431997
PNG
(CHEMBL2348723)
Show SMILES CC(C)C(=O)Nc1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C12H13N3O2/c1-7(2)11(16)13-10-8-5-3-4-6-9(8)12(17)15-14-10/h3-7H,1-2H3,(H,15,17)(H,13,14,16)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50431998
PNG
(CHEMBL2348745)
Show SMILES CC(=O)Nc1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C10H9N3O2/c1-6(14)11-9-7-4-2-3-5-8(7)10(15)13-12-9/h2-5H,1H3,(H,13,15)(H,11,12,14)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50431999
PNG
(CHEMBL2348744)
Show SMILES O=C(Cc1ccccc1)Nc1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C16H13N3O2/c20-14(10-11-6-2-1-3-7-11)17-15-12-8-4-5-9-13(12)16(21)19-18-15/h1-9H,10H2,(H,19,21)(H,17,18,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432000
PNG
(CHEMBL2348743)
Show SMILES CCCCCC(=O)Nc1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C14H17N3O2/c1-2-3-4-9-12(18)15-13-10-7-5-6-8-11(10)14(19)17-16-13/h5-8H,2-4,9H2,1H3,(H,17,19)(H,15,16,18)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432001
PNG
(CHEMBL2348742)
Show SMILES CC(C)C(=O)N(C(=O)C(C)C)c1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C16H19N3O3/c1-9(2)15(21)19(16(22)10(3)4)13-11-7-5-6-8-12(11)14(20)18-17-13/h5-10H,1-4H3,(H,18,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432002
PNG
(CHEMBL2348741)
Show SMILES CC(=O)N(C(C)=O)c1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C12H11N3O3/c1-7(16)15(8(2)17)11-9-5-3-4-6-10(9)12(18)14-13-11/h3-6H,1-2H3,(H,14,18)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432003
PNG
(CHEMBL2348740)
Show SMILES Clc1nnc(NC(=O)Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C16H12ClN3O/c17-15-12-8-4-5-9-13(12)16(20-19-15)18-14(21)10-11-6-2-1-3-7-11/h1-9H,10H2,(H,18,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432004
PNG
(CHEMBL2348739)
Show SMILES Clc1nnc(N(C(=O)Cc2ccccc2)C(=O)Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H18ClN3O2/c25-23-19-13-7-8-14-20(19)24(27-26-23)28(21(29)15-17-9-3-1-4-10-17)22(30)16-18-11-5-2-6-12-18/h1-14H,15-16H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432005
PNG
(CHEMBL2348738)
Show SMILES CCCCCC(=O)N(C(=O)CCCCC)c1nnc(Cl)c2ccccc12
Show InChI InChI=1S/C20H26ClN3O2/c1-3-5-7-13-17(25)24(18(26)14-8-6-4-2)20-16-12-10-9-11-15(16)19(21)22-23-20/h9-12H,3-8,13-14H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432006
PNG
(CHEMBL2348737)
Show SMILES O=C(Nc1cc(-c2ccccc2)c(=O)[nH]n1)c1ccccc1
Show InChI InChI=1S/C17H13N3O2/c21-16(13-9-5-2-6-10-13)18-15-11-14(17(22)20-19-15)12-7-3-1-4-8-12/h1-11H,(H,20,22)(H,18,19,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432007
PNG
(CHEMBL2348736)
Show SMILES Clc1nnc(NC(=O)c2ccccc2)cc1-c1ccccc1
Show InChI InChI=1S/C17H12ClN3O/c18-16-14(12-7-3-1-4-8-12)11-15(20-21-16)19-17(22)13-9-5-2-6-10-13/h1-11H,(H,19,20,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432008
PNG
(CHEMBL2348735)
Show SMILES Nc1cc(-c2ccccc2)c(=O)[nH]n1
Show InChI InChI=1S/C10H9N3O/c11-9-6-8(10(14)13-12-9)7-4-2-1-3-5-7/h1-6H,(H2,11,12)(H,13,14)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432009
PNG
(CHEMBL2348734)
Show SMILES CC(=O)Nc1cc(-c2ccccc2)c(=O)[nH]n1
Show InChI InChI=1S/C12H11N3O2/c1-8(16)13-11-7-10(12(17)15-14-11)9-5-3-2-4-6-9/h2-7H,1H3,(H,15,17)(H,13,14,16)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432010
PNG
(CHEMBL2348733)
Show SMILES Nc1n[nH]c(=O)cc1-c1ccccc1
Show InChI InChI=1S/C10H9N3O/c11-10-8(6-9(14)12-13-10)7-4-2-1-3-5-7/h1-6H,(H2,11,13)(H,12,14)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432011
PNG
(CHEMBL2348732)
Show SMILES CC(=O)Nc1n[nH]c(=O)cc1-c1ccccc1
Show InChI InChI=1S/C12H11N3O2/c1-8(16)13-12-10(7-11(17)14-15-12)9-5-3-2-4-6-9/h2-7H,1H3,(H,14,17)(H,13,15,16)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432012
PNG
(CHEMBL2348731)
Show SMILES CN1CCC(CC1)Nc1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C14H18N4O/c1-18-8-6-10(7-9-18)15-13-11-4-2-3-5-12(11)14(19)17-16-13/h2-5,10H,6-9H2,1H3,(H,15,16)(H,17,19)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432013
PNG
(CHEMBL2348730)
Show SMILES O=c1[nH]nc(NCCN2CCCCC2)c2ccccc12
Show InChI InChI=1S/C15H20N4O/c20-15-13-7-3-2-6-12(13)14(17-18-15)16-8-11-19-9-4-1-5-10-19/h2-3,6-7H,1,4-5,8-11H2,(H,16,17)(H,18,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432014
PNG
(CHEMBL2348729)
Show SMILES CCCNc1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C11H13N3O/c1-2-7-12-10-8-5-3-4-6-9(8)11(15)14-13-10/h3-6H,2,7H2,1H3,(H,12,13)(H,14,15)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432015
PNG
(CHEMBL2348728)
Show SMILES O=c1[nH]nc(NCc2ccccc2)c2ccccc12
Show InChI InChI=1S/C15H13N3O/c19-15-13-9-5-4-8-12(13)14(17-18-15)16-10-11-6-2-1-3-7-11/h1-9H,10H2,(H,16,17)(H,18,19)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432016
PNG
(CHEMBL2348727)
Show SMILES CN1CCC(CC1)Nc1cc(-c2ccccc2)c(=O)[nH]n1
Show InChI InChI=1S/C16H20N4O/c1-20-9-7-13(8-10-20)17-15-11-14(16(21)19-18-15)12-5-3-2-4-6-12/h2-6,11,13H,7-10H2,1H3,(H,17,18)(H,19,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432017
PNG
(CHEMBL2348726)
Show SMILES O=c1cc(c(NCCN2CCCCC2)n[nH]1)-c1ccccc1
Show InChI InChI=1S/C17H22N4O/c22-16-13-15(14-7-3-1-4-8-14)17(20-19-16)18-9-12-21-10-5-2-6-11-21/h1,3-4,7-8,13H,2,5-6,9-12H2,(H,18,20)(H,19,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432018
PNG
(CHEMBL2348750)
Show SMILES O=c1[nH]nc(NCCN2CCCCC2)cc1-c1ccccc1
Show InChI InChI=1S/C17H22N4O/c22-17-15(14-7-3-1-4-8-14)13-16(19-20-17)18-9-12-21-10-5-2-6-11-21/h1,3-4,7-8,13H,2,5-6,9-12H2,(H,18,19)(H,20,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50432019
PNG
(CHEMBL2348749)
Show SMILES CCCNc1n[nH]c(=O)cc1-c1ccccc1
Show InChI InChI=1S/C13H15N3O/c1-2-8-14-13-11(9-12(17)15-16-13)10-6-4-3-5-7-10/h3-7,9H,2,8H2,1H3,(H,14,16)(H,15,17)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50431992
PNG
(CHEMBL2348748)
Show SMILES CCCNc1cc(-c2ccccc2)c(=O)[nH]n1
Show InChI InChI=1S/C13H15N3O/c1-2-8-14-12-9-11(13(17)16-15-12)10-6-4-3-5-7-10/h3-7,9H,2,8H2,1H3,(H,14,15)(H,16,17)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50431993
PNG
(CHEMBL2348747)
Show SMILES O=c1cc(c(NCc2ccccc2)n[nH]1)-c1ccccc1
Show InChI InChI=1S/C17H15N3O/c21-16-11-15(14-9-5-2-6-10-14)17(20-19-16)18-12-13-7-3-1-4-8-13/h1-11H,12H2,(H,18,20)(H,19,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50431994
PNG
(CHEMBL2348746)
Show SMILES O=c1[nH]nc(NCc2ccccc2)cc1-c1ccccc1
Show InChI InChI=1S/C17H15N3O/c21-17-15(14-9-5-2-6-10-14)11-16(19-20-17)18-12-13-7-3-1-4-8-13/h1-11H,12H2,(H,18,19)(H,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.027
BindingDB Entry DOI: 10.7270/Q2T1551T
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50440393
PNG
(CHEMBL2425487)
Show SMILES COc1cc(C)c(cc1O)-c1c2c(n3ccc4cc(O)c(OC)cc4c13)c(=O)oc1cc(O)c(OC)cc21
Show InChI InChI=1S/C29H23NO8/c1-13-7-22(35-2)19(32)9-15(13)25-26-17-11-24(37-4)20(33)12-21(17)38-29(34)28(26)30-6-5-14-8-18(31)23(36-3)10-16(14)27(25)30/h5-12,31-33H,1-4H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Nagasaki University

Curated by ChEMBL


Assay Description
Inhibition of recombinant CDK5/p25 (unknown origin) expressed in Escherichia coli using [gamma-33P]ATP after 30 mins


J Med Chem 56: 7289-301 (2013)


Article DOI: 10.1021/jm400719y
BindingDB Entry DOI: 10.7270/Q2W37XQZ
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50077360
PNG
(3,10-Dihydroxy-13-(3-hydroxy-4-methoxy-phenyl)-2,1...)
Show SMILES COc1ccc(cc1O)-c1c2c(n3ccc4cc(O)c(OC)cc4c13)c(=O)oc1cc(O)c(OC)cc21
Show InChI InChI=1S/C28H21NO8/c1-34-20-5-4-14(9-17(20)30)24-25-16-11-23(36-3)19(32)12-21(16)37-28(33)27(25)29-7-6-13-8-18(31)22(35-2)10-15(13)26(24)29/h4-12,30-32H,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Nagasaki University

Curated by ChEMBL


Assay Description
Inhibition of recombinant CDK5/p25 (unknown origin) expressed in Escherichia coli using [gamma-33P]ATP after 30 mins


J Med Chem 56: 7289-301 (2013)


Article DOI: 10.1021/jm400719y
BindingDB Entry DOI: 10.7270/Q2W37XQZ
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50440473
PNG
(CHEMBL2425904)
Show SMILES Nc1nc(Nc2ccc(cc2)S(=O)(=O)NCCO)nc(OCC2CCCCC2)c1[N+](=O)[N-]C#N
Show InChI InChI=1S/C20H26N8O5S/c21-13-23-28(30)17-18(22)26-20(27-19(17)33-12-14-4-2-1-3-5-14)25-15-6-8-16(9-7-15)34(31,32)24-10-11-29/h6-9,14,24,29H,1-5,10-12H2,(H3,22,25,26,27)/b28-23-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 560n/an/an/an/an/an/a



Universit£ degli Studi di Torino

Curated by ChEMBL


Assay Description
Inhibition of CDK5/P25 (unknown origin)


Eur J Med Chem 68: 333-8 (2013)


Article DOI: 10.1016/j.ejmech.2013.07.031
BindingDB Entry DOI: 10.7270/Q2ZW1NB0
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50440474
PNG
(CHEMBL2425903)
Show SMILES CNS(=O)(=O)c1ccc(Nc2nc(N)c(c(OCC3CCCCC3)n2)[N+](=O)[N-]C#N)cc1
Show InChI InChI=1S/C19H24N8O4S/c1-22-32(29,30)15-9-7-14(8-10-15)24-19-25-17(21)16(27(28)23-12-20)18(26-19)31-11-13-5-3-2-4-6-13/h7-10,13,22H,2-6,11H2,1H3,(H3,21,24,25,26)/b27-23-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 775n/an/an/an/an/an/a



Universit£ degli Studi di Torino

Curated by ChEMBL


Assay Description
Inhibition of CDK5/P25 (unknown origin)


Eur J Med Chem 68: 333-8 (2013)


Article DOI: 10.1016/j.ejmech.2013.07.031
BindingDB Entry DOI: 10.7270/Q2ZW1NB0
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7533
PNG
((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Show SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 280n/an/an/an/an/an/a



Dr. Reddy's Laboratories, Ameerpet, Hyderabad, India.

Curated by ChEMBL


Assay Description
Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into biotinylated PKTPKKAKKL substrate after 60 mins by scintillation counting


Eur J Med Chem 46: 2066-74 (2011)


Article DOI: 10.1016/j.ejmech.2011.02.059
BindingDB Entry DOI: 10.7270/Q28S4R6B
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50304113
PNG
(CHEMBL604270 | N-((Z)-5-Bromo-3,2'-dioxo-1,3,1',2'...)
Show SMILES CC(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccc(Br)cc4C3=O)c2c1
Show InChI InChI=1S/C18H12BrN3O3/c1-8(23)20-10-3-5-13-11(7-10)15(18(25)22-13)16-17(24)12-6-9(19)2-4-14(12)21-16/h2-7,21H,1H3,(H,20,23)(H,22,25)/b16-15-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting


Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50423711
PNG
(CHEMBL594403)
Show SMILES O[N-]c1c([nH]c2ccccc12)C1=c2ccc(cc2=[NH+]C1=O)[N+]([O-])=O
Show InChI InChI=1S/C16H10N4O4/c21-16-13(9-6-5-8(20(23)24)7-12(9)18-16)15-14(19-22)10-3-1-2-4-11(10)17-15/h1-7H,(H3,17,18,19,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting


Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50304112
PNG
((Z)-5'-Amino-1H,1'H-[2,3']biindolylidene-3,2'-dion...)
Show SMILES Nc1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H12N4O2/c17-8-5-6-12-10(7-8)13(16(21)19-12)15-14(20-22)9-3-1-2-4-11(9)18-15/h1-7,13,18H,17H2,(H,19,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting


Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50304114
PNG
(CHEMBL445348 | N-{(Z)-3-[(E)-Hydroxyimino]-2'-oxo-...)
Show SMILES CC(=O)Nc1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C18H14N4O3/c1-9(23)19-10-6-7-14-12(8-10)15(18(24)21-14)17-16(22-25)11-4-2-3-5-13(11)20-17/h2-8,15,20H,1H3,(H,19,23)(H,21,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting


Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 1586 total )  |  Next  |  Last  >>
Jump to: