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Compile Data Set for Download or QSAR

Found 1996 hits Enz. Inhib. hit(s) with Target = 'Cytochrome P450 11B1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347679
PNG
((E)-2-(4-Chlorophenoxy)-3- (dimethylamino)-1-(2-me...)
Show SMILES COc1ccccc1C(=O)C(\Oc1ccc(Cl)cc1)=C/N(C)C
Show InChI InChI=1S/C18H18ClNO3/c1-20(2)12-17(23-14-10-8-13(19)9-11-14)18(21)15-6-4-5-7-16(15)22-3/h4-12H,1-3H3/b17-12+
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n/an/an/an/a 0.00100n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347718
PNG
(4-[(Z)-1-(2-Benzyloxybenzoyl)-2- (dimethylamino)vi...)
Show SMILES CN(C)\C=C(/Oc1ccc(cc1)C#N)C(=O)c1ccccc1OCc1ccccc1
Show InChI InChI=1S/C25H22N2O3/c1-27(2)17-24(30-21-14-12-19(16-26)13-15-21)25(28)22-10-6-7-11-23(22)29-18-20-8-4-3-5-9-20/h3-15,17H,18H2,1-2H3/b24-17-
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n/an/an/an/a 0.00100n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347757
PNG
(CHEM-US-00174 | US9790217, 79)
Show SMILES N#Cc1ccc(Oc2cn[nH]c2-c2ccccc2OCc2ccccn2)cc1
Show InChI InChI=1S/C22H16N4O2/c23-13-16-8-10-18(11-9-16)28-21-14-25-26-22(21)19-6-1-2-7-20(19)27-15-17-5-3-4-12-24-17/h1-12,14H,15H2,(H,25,26)
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n/an/an/an/a 0.00300n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347763
PNG
(CHEM-US-00182 | US9790217, 85)
Show SMILES Fc1c(OCc2ccncc2)cccc1-c1[nH]ncc1Oc1ccc(cc1)C#N
Show InChI InChI=1S/C22H15FN4O2/c23-21-18(2-1-3-19(21)28-14-16-8-10-25-11-9-16)22-20(13-26-27-22)29-17-6-4-15(12-24)5-7-17/h1-11,13H,14H2,(H,26,27)
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n/an/an/an/a 0.00500n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347754
PNG
(4-[[3-[2-(Pyridin-4-ylmethoxy)phenyl]-1H-pyrazol-4...)
Show SMILES N#Cc1ccc(Oc2cn[nH]c2-c2ccccc2OCc2ccncc2)cc1
Show InChI InChI=1S/C22H16N4O2/c23-13-16-5-7-18(8-6-16)28-21-14-25-26-22(21)19-3-1-2-4-20(19)27-15-17-9-11-24-12-10-17/h1-12,14H,15H2,(H,25,26)
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n/an/an/an/a 0.00700n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347758
PNG
(CHEM-US-00175 | US9790217, 80)
Show SMILES N#Cc1ccc(Oc2cn[nH]c2-c2ccccc2OCc2cn[nH]c2)cc1
Show InChI InChI=1S/C20H15N5O2/c21-9-14-5-7-16(8-6-14)27-19-12-24-25-20(19)17-3-1-2-4-18(17)26-13-15-10-22-23-11-15/h1-8,10-12H,13H2,(H,22,23)(H,24,25)
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n/an/an/an/a 0.00700n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347756
PNG
(CHEM-US-00173 | US9790217, 78)
Show SMILES Oc1ccccc1-c1[nH]ncc1Oc1ccc(cc1)C#N
Show InChI InChI=1S/C16H11N3O2/c17-9-11-5-7-12(8-6-11)21-15-10-18-19-16(15)13-3-1-2-4-14(13)20/h1-8,10,20H,(H,18,19)
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n/an/an/an/a 0.0110n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347755
PNG
(CHEM-US-00172 | US9790217, 77)
Show SMILES N#Cc1ccc(Oc2cn[nH]c2-c2ccccc2OCc2ccnnc2)cc1
Show InChI InChI=1S/C21H15N5O2/c22-11-15-5-7-17(8-6-15)28-20-13-25-26-21(20)18-3-1-2-4-19(18)27-14-16-9-10-23-24-12-16/h1-10,12-13H,14H2,(H,25,26)
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n/an/an/an/a 0.0110n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347679
PNG
((E)-2-(4-Chlorophenoxy)-3- (dimethylamino)-1-(2-me...)
Show SMILES COc1ccccc1C(=O)C(\Oc1ccc(Cl)cc1)=C/N(C)C
Show InChI InChI=1S/C18H18ClNO3/c1-20(2)12-17(23-14-10-8-13(19)9-11-14)18(21)15-6-4-5-7-16(15)22-3/h4-12H,1-3H3/b17-12+
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n/an/an/an/a 0.0120n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347762
PNG
(4-[[3-(2-Fluoro-3-hydroxyphenyl)-1H-pyrazol-4-yl]o...)
Show SMILES Oc1cccc(-c2[nH]ncc2Oc2ccc(cc2)C#N)c1F
Show InChI InChI=1S/C16H10FN3O2/c17-15-12(2-1-3-13(15)21)16-14(9-19-20-16)22-11-6-4-10(8-18)5-7-11/h1-7,9,21H,(H,19,20)
PDB

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n/an/an/an/a 0.0170n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347703
PNG
((E)-1-[(2-Chlorobenzoyl)-2- (dimethylamino)vinylox...)
Show SMILES CN(C)C(=C\OC1(CC=CC=C1)C#N)\C(=O)c1ccccc1Cl
Show InChI InChI=1/C18H17ClN2O2/c1-21(2)16(17(22)14-8-4-5-9-15(14)19)12-23-18(13-20)10-6-3-7-11-18/h3-10,12H,11H2,1-2H3/b16-12+
PDB

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n/an/an/an/a 0.0180n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347764
PNG
(CHEM-US-00183 | US9790217, 86)
Show SMILES Fc1c(OCc2ccc(Cl)nc2)cccc1-c1[nH]ncc1Oc1ccc(cc1)C#N
Show InChI InChI=1S/C22H14ClFN4O2/c23-20-9-6-15(11-26-20)13-29-18-3-1-2-17(21(18)24)22-19(12-27-28-22)30-16-7-4-14(10-25)5-8-16/h1-9,11-12H,13H2,(H,27,28)
PDB

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n/an/an/an/a 0.0280n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347710
PNG
(Methyl 3-[(E)-2-(4-cyanophenoxy)- 3-(dimethylamino...)
Show SMILES COC(=O)c1cccc(c1)C(=O)C(\Oc1ccc(cc1)C#N)=C/N(C)C
Show InChI InChI=1S/C20H18N2O4/c1-22(2)13-18(26-17-9-7-14(12-21)8-10-17)19(23)15-5-4-6-16(11-15)20(24)25-3/h4-11,13H,1-3H3/b18-13+
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n/an/an/an/a 0.0310n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347729
PNG
(CHEM-US-00129 | US9790217, 52)
Show SMILES Cc1cc(COc2cccc(c2)-c2[nH]ncc2Oc2ccc(cc2)C#N)on1
Show InChI InChI=1S/C21H16N4O3/c1-14-9-19(28-25-14)13-26-18-4-2-3-16(10-18)21-20(12-23-24-21)27-17-7-5-15(11-22)6-8-17/h2-10,12H,13H2,1H3,(H,23,24)
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n/an/an/an/a 0.0320n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347752
PNG
(4-[[3-[3-[[3-Fluoro-3-(hydroxymethyl)azetidin-1-yl...)
Show SMILES OCC1(F)CN(Cc2cccc(c2)-c2[nH]ncc2Oc2ccc(cc2)C#N)C1
Show InChI InChI=1S/C21H19FN4O2/c22-21(14-27)12-26(13-21)11-16-2-1-3-17(8-16)20-19(10-24-25-20)28-18-6-4-15(9-23)5-7-18/h1-8,10,27H,11-14H2,(H,24,25)
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n/an/an/an/a 0.0360n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347745
PNG
(CHEM-US-00162 | US9790217, 70)
Show SMILES N#Cc1ccc(Oc2cn[nH]c2-c2cccc(COc3cccnn3)c2)cc1
Show InChI InChI=1S/C21H15N5O2/c22-12-15-6-8-18(9-7-15)28-19-13-24-26-21(19)17-4-1-3-16(11-17)14-27-20-5-2-10-23-25-20/h1-11,13H,14H2,(H,24,26)
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n/an/an/an/a 0.0380n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347731
PNG
(CHEM-US-00131 | US9790217, 54)
Show SMILES N#Cc1ccc(Oc2cn[nH]c2-c2cccc(OCc3ccncc3)c2)cc1
Show InChI InChI=1S/C22H16N4O2/c23-13-16-4-6-19(7-5-16)28-21-14-25-26-22(21)18-2-1-3-20(12-18)27-15-17-8-10-24-11-9-17/h1-12,14H,15H2,(H,25,26)
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n/an/an/an/a 0.0460n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347744
PNG
(4-[[3-[3-[(6-Fluoropyridin-2-yl)oxymethyl]phenyl]-...)
Show SMILES Fc1cccc(OCc2cccc(c2)-c2[nH]ncc2Oc2ccc(cc2)C#N)n1
Show InChI InChI=1S/C22H15FN4O2/c23-20-5-2-6-21(26-20)28-14-16-3-1-4-17(11-16)22-19(13-25-27-22)29-18-9-7-15(12-24)8-10-18/h1-11,13H,14H2,(H,25,27)
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n/an/an/an/a 0.0480n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM351275
PNG
((rac)-6-[4-[1-(1-Acetylpiperidin-4-yl)ethyl]-1H-py...)
Show SMILES CC(C1CCN(CC1)C(C)=O)c1c[nH]nc1-c1ccc2N(C)C(=O)CCc2c1F
Show InChI InChI=1/C22H27FN4O2/c1-13(15-8-10-27(11-9-15)14(2)28)18-12-24-25-22(18)17-4-6-19-16(21(17)23)5-7-20(29)26(19)3/h4,6,12-13,15H,5,7-11H2,1-3H3,(H,24,25)
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n/an/an/an/a 0.0490n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...


US Patent US9796702 (2017)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2DB840G
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347728
PNG
(US9790217, 51)
Show SMILES N#Cc1ccc(Oc2cn[nH]c2-c2cccc(OCc3cccnc3)c2)cc1
Show InChI InChI=1S/C22H16N4O2/c23-12-16-6-8-19(9-7-16)28-21-14-25-26-22(21)18-4-1-5-20(11-18)27-15-17-3-2-10-24-13-17/h1-11,13-14H,15H2,(H,25,26)
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n/an/an/an/a 0.0510n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347681
PNG
((E)-2-(4-Chlorophenoxy)-1-(2- chlorophenyl)-3-(dim...)
Show SMILES CN(C)\C=C(\Oc1ccc(Cl)cc1)C(=O)c1ccccc1Cl
Show InChI InChI=1S/C17H15Cl2NO2/c1-20(2)11-16(22-13-9-7-12(18)8-10-13)17(21)14-5-3-4-6-15(14)19/h3-11H,1-2H3/b16-11+
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n/an/an/an/a 0.0520n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347727
PNG
(4-[[3-[3-(Pyridin-2-ylmethoxy)phenyl]-1H-pyrazol-4...)
Show SMILES N#Cc1ccc(Oc2cn[nH]c2-c2cccc(OCc3ccccn3)c2)cc1
Show InChI InChI=1S/C22H16N4O2/c23-13-16-7-9-19(10-8-16)28-21-14-25-26-22(21)17-4-3-6-20(12-17)27-15-18-5-1-2-11-24-18/h1-12,14H,15H2,(H,25,26)
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n/an/an/an/a 0.0520n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347713
PNG
(4-[(Z)-1-(3-Benzyloxybenzoyl)-2- (dimethylamino)vi...)
Show SMILES CN(C)\C=C(/Oc1ccc(cc1)C#N)C(=O)c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C25H22N2O3/c1-27(2)17-24(30-22-13-11-19(16-26)12-14-22)25(28)21-9-6-10-23(15-21)29-18-20-7-4-3-5-8-20/h3-15,17H,18H2,1-2H3/b24-17-
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n/an/an/an/a 0.0530n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM351274
PNG
((rac)-6-[4-[1-(1-Acetylpiperidin-4-yl)ethyl]-1H-py...)
Show SMILES CC(C1CCN(CC1)C(C)=O)c1c[nH]nc1-c1cc2CCC(=O)N(C)c2cc1F
Show InChI InChI=1/C22H27FN4O2/c1-13(15-6-8-27(9-7-15)14(2)28)18-12-24-25-22(18)17-10-16-4-5-21(29)26(3)20(16)11-19(17)23/h10-13,15H,4-9H2,1-3H3,(H,24,25)
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n/an/an/an/a 0.0670n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...


US Patent US9796702 (2017)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2DB840G
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347712
PNG
(4-[(Z)-1-(2-Chloro-3-fluoro- benzoyl)- (dimethylam...)
Show SMILES CN(C)\C=C(/Oc1ccc(cc1)C#N)C(=O)c1cccc(F)c1Cl
Show InChI InChI=1S/C18H14ClFN2O2/c1-22(2)11-16(24-13-8-6-12(10-21)7-9-13)18(23)14-4-3-5-15(20)17(14)19/h3-9,11H,1-2H3/b16-11-
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n/an/an/an/a 0.0690n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM351277
PNG
((+)-6-[4-[(1R)-1-(1-acetylpiperidin-4-yl)ethyl]-1H...)
Show SMILES C[C@H](C1CCN(CC1)C(C)=O)c1c[nH]nc1-c1ccc2N(C)C(=O)CCc2c1F
Show InChI InChI=1S/C22H27FN4O2/c1-13(15-8-10-27(11-9-15)14(2)28)18-12-24-25-22(18)17-4-6-19-16(21(17)23)5-7-20(29)26(19)3/h4,6,12-13,15H,5,7-11H2,1-3H3,(H,24,25)/t13-/m1/s1
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n/an/an/an/a 0.0740n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...


US Patent US9796702 (2017)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2DB840G
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347685
PNG
((E)-2-(4-Chlorophenoxy)-1-[2- (difluoromethoxy)phe...)
Show SMILES CN(C)\C=C(\Oc1ccc(Cl)cc1)C(=O)c1ccccc1OC(F)F
Show InChI InChI=1S/C18H16ClF2NO3/c1-22(2)11-16(24-13-9-7-12(19)8-10-13)17(23)14-5-3-4-6-15(14)25-18(20)21/h3-11,18H,1-2H3/b16-11+
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n/an/an/an/a 0.0760n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM351263
PNG
(CHEM-US-00074 | US9796702, 24 | US9796702, 26)
Show SMILES CN1C(=O)CCc2c(F)c(ccc12)-c1n[nH]cc1CC1CCN(CC1)C(=O)c1ccnn1C
Show InChI InChI=1S/C24H27FN6O2/c1-29-19-5-3-18(22(25)17(19)4-6-21(29)32)23-16(14-26-28-23)13-15-8-11-31(12-9-15)24(33)20-7-10-27-30(20)2/h3,5,7,10,14-15H,4,6,8-9,11-13H2,1-2H3,(H,26,28)
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n/an/an/an/a 0.0760n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...


US Patent US9796702 (2017)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2DB840G
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347725
PNG
(4-[[3-(3-Hydroxyphenyl)-1H-pyrazol-4-yl]oxy]benzon...)
Show SMILES Oc1cccc(c1)-c1[nH]ncc1Oc1ccc(cc1)C#N
Show InChI InChI=1S/C16H11N3O2/c17-9-11-4-6-14(7-5-11)21-15-10-18-19-16(15)12-2-1-3-13(20)8-12/h1-8,10,20H,(H,18,19)
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n/an/an/an/a 0.0830n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347726
PNG
(4-[[3-[3-(Hydroxymethyl)phenyl]-1H-pyrazol-4-yl]ox...)
Show SMILES OCc1cccc(c1)-c1[nH]ncc1Oc1ccc(cc1)C#N
Show InChI InChI=1S/C17H13N3O2/c18-9-12-4-6-15(7-5-12)22-16-10-19-20-17(16)14-3-1-2-13(8-14)11-21/h1-8,10,21H,11H2,(H,19,20)
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n/an/an/an/a 0.0850n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347733
PNG
(CHEM-US-00133 | US9790217, 56)
Show SMILES Cn1cc(COc2cccc(c2)-c2[nH]ncc2Oc2ccc(cc2)C#N)cn1
Show InChI InChI=1S/C21H17N5O2/c1-26-13-16(11-24-26)14-27-19-4-2-3-17(9-19)21-20(12-23-25-21)28-18-7-5-15(10-22)6-8-18/h2-9,11-13H,14H2,1H3,(H,23,25)
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n/an/an/an/a 0.0940n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1, mitochondrial


(Homo sapiens (Human))
BDBM249226
PNG
(US9458135, 14)
Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(CSc2cccc(C)n2)c1
Show InChI InChI=1S/C22H21N3OS/c1-15-4-3-5-21(24-15)27-14-16-10-19(13-23-12-16)17-6-8-20-18(11-17)7-9-22(26)25(20)2/h3-6,8,10-13H,7,9,14H2,1-2H3
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n/an/an/an/a 0.100n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...


US Patent US9458135 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5F04
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347735
PNG
(4-[[5-(3-Butoxyphenyl)-1H-pyrazol-4-yl]oxy]benzoni...)
Show SMILES CCCCOc1cccc(c1)-c1[nH]ncc1Oc1ccc(cc1)C#N
Show InChI InChI=1S/C20H19N3O2/c1-2-3-11-24-18-6-4-5-16(12-18)20-19(14-22-23-20)25-17-9-7-15(13-21)8-10-17/h4-10,12,14H,2-3,11H2,1H3,(H,22,23)
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n/an/an/an/a 0.102n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM351261
PNG
(CHEM-US-00072 | US9796702, 22)
Show SMILES CCS(=O)(=O)N1CCC(Cc2c[nH]nc2-c2ccc3N(C)C(=O)CCc3c2F)CC1
Show InChI InChI=1S/C21H27FN4O3S/c1-3-30(28,29)26-10-8-14(9-11-26)12-15-13-23-24-21(15)17-4-6-18-16(20(17)22)5-7-19(27)25(18)2/h4,6,13-14H,3,5,7-12H2,1-2H3,(H,23,24)
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n/an/an/an/a 0.133n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...


US Patent US9796702 (2017)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2DB840G
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347705
PNG
(4-[(E)-1-(2-Chlorobenzoyl)-2- (dimethylamino)vinyl...)
Show SMILES CN(C)\C=C(\Oc1ccc(cc1F)C#N)C(=O)c1ccccc1Cl
Show InChI InChI=1S/C18H14ClFN2O2/c1-22(2)11-17(18(23)13-5-3-4-6-14(13)19)24-16-8-7-12(10-21)9-15(16)20/h3-9,11H,1-2H3/b17-11+
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n/an/an/an/a 0.134n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347753
PNG
(4-[[3-[3-(Morpholin-4-ylmethyl)phenyl]-1H-pyrazol-...)
Show SMILES N#Cc1ccc(Oc2cn[nH]c2-c2cccc(CN3CCOCC3)c2)cc1
Show InChI InChI=1S/C21H20N4O2/c22-13-16-4-6-19(7-5-16)27-20-14-23-24-21(20)18-3-1-2-17(12-18)15-25-8-10-26-11-9-25/h1-7,12,14H,8-11,15H2,(H,23,24)
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n/an/an/an/a 0.139n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347724
PNG
(CHEM-US-00117 | US9790217, 47)
Show SMILES OCC1CN(C1)C(=O)c1cccc(c1)-c1[nH]ncc1Oc1ccc(cc1)C#N
Show InChI InChI=1S/C21H18N4O3/c22-9-14-4-6-18(7-5-14)28-19-10-23-24-20(19)16-2-1-3-17(8-16)21(27)25-11-15(12-25)13-26/h1-8,10,15,26H,11-13H2,(H,23,24)
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n/an/an/an/a 0.159n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347692
PNG
((E)-2-(4-Chlorophenoxy)-1-(2,4- difluorophenyl)-3-...)
Show SMILES CN(C)\C=C(\Oc1ccc(Cl)cc1)C(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C17H14ClF2NO2/c1-21(2)10-16(23-13-6-3-11(18)4-7-13)17(22)14-8-5-12(19)9-15(14)20/h3-10H,1-2H3/b16-10+
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n/an/an/an/a 0.159n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347706
PNG
((E)-1-[(2,3-Difluorobenzoyl)-2-(dimethylamino)viny...)
Show SMILES CN(C)C(=C\OC1(CC=CC=C1)C#N)\C(=O)c1cccc(F)c1F
Show InChI InChI=1/C18H16F2N2O2/c1-22(2)15(11-24-18(12-21)9-4-3-5-10-18)17(23)13-7-6-8-14(19)16(13)20/h3-9,11H,10H2,1-2H3/b15-11+
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n/an/an/an/a 0.161n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347686
PNG
((E)-2-(4-Chlorophenoxy)-3- (dimethylamino)-1-(2-fl...)
Show SMILES CN(C)\C=C(\Oc1ccc(Cl)cc1)C(=O)c1ccccc1F
Show InChI InChI=1S/C17H15ClFNO2/c1-20(2)11-16(22-13-9-7-12(18)8-10-13)17(21)14-5-3-4-6-15(14)19/h3-11H,1-2H3/b16-11+
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n/an/an/an/a 0.167n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347759
PNG
(CHEM-US-00176 | US9790217, 81)
Show SMILES Cn1nncc1COc1ccccc1-c1[nH]ncc1Oc1ccc(cc1)C#N
Show InChI InChI=1S/C20H16N6O2/c1-26-15(11-23-25-26)13-27-18-5-3-2-4-17(18)20-19(12-22-24-20)28-16-8-6-14(10-21)7-9-16/h2-9,11-12H,13H2,1H3,(H,22,24)
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n/an/an/an/a 0.171n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM351260
PNG
(6-[4-[(1-Acetyl-4-piperidyl)methyl]-1H-pyrazol-3-y...)
Show SMILES CN1C(=O)CCc2c(F)c(ccc12)-c1n[nH]cc1CC1CCN(CC1)C(C)=O
Show InChI InChI=1S/C21H25FN4O2/c1-13(27)26-9-7-14(8-10-26)11-15-12-23-24-21(15)17-3-5-18-16(20(17)22)4-6-19(28)25(18)2/h3,5,12,14H,4,6-11H2,1-2H3,(H,23,24)
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n/an/an/an/a 0.184n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...


US Patent US9796702 (2017)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2DB840G
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347707
PNG
(4-[(E)-1-(3-Chloro-2-fluoro- benzoyl)-2- (dimethyl...)
Show SMILES CN(C)\C=C(\Oc1ccc(cc1)C#N)C(=O)c1cccc(Cl)c1F
Show InChI InChI=1S/C18H14ClFN2O2/c1-22(2)11-16(24-13-8-6-12(10-21)7-9-13)18(23)14-4-3-5-15(19)17(14)20/h3-9,11H,1-2H3/b16-11+
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n/an/an/an/a 0.191n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347730
PNG
(CHEM-US-00130 | US9790217, 53)
Show SMILES Cn1nncc1COc1cccc(c1)-c1[nH]ncc1Oc1ccc(cc1)C#N
Show InChI InChI=1S/C20H16N6O2/c1-26-16(11-23-25-26)13-27-18-4-2-3-15(9-18)20-19(12-22-24-20)28-17-7-5-14(10-21)6-8-17/h2-9,11-12H,13H2,1H3,(H,22,24)
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n/an/an/an/a 0.198n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM351278
PNG
(5-Chloro-6-[4-[(2-ethylsulfonyl-2-azaspiro[3.3]hep...)
Show SMILES CCS(=O)(=O)N1CC2(CC(Cc3c[nH]nc3-c3ccc4N(C)C(=O)CCc4c3Cl)C2)C1
Show InChI InChI=1S/C22H27ClN4O3S/c1-3-31(29,30)27-12-22(13-27)9-14(10-22)8-15-11-24-25-21(15)17-4-6-18-16(20(17)23)5-7-19(28)26(18)2/h4,6,11,14H,3,5,7-10,12-13H2,1-2H3,(H,24,25)
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n/an/an/an/a 0.215n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...


US Patent US9796702 (2017)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2DB840G
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM351257
PNG
(6-[4-[(1-Ethylsulfonyl-4-piperidyl)methyl]-1H-pyra...)
Show SMILES CCS(=O)(=O)N1CCC(Cc2c[nH]nc2-c2ccc3N(C)C(=O)CCc3c2)CC1
Show InChI InChI=1S/C21H28N4O3S/c1-3-29(27,28)25-10-8-15(9-11-25)12-18-14-22-23-21(18)17-4-6-19-16(13-17)5-7-20(26)24(19)2/h4,6,13-15H,3,5,7-12H2,1-2H3,(H,22,23)
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n/an/an/an/a 0.216n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...


US Patent US9796702 (2017)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2DB840G
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347711
PNG
((E)-1-(2-Chloro-3-fluoro-phenyl)-2- (4-chloropheno...)
Show SMILES CN(C)\C=C(\Oc1ccc(Cl)cc1)C(=O)c1cccc(F)c1Cl
Show InChI InChI=1S/C17H14Cl2FNO2/c1-21(2)10-15(23-12-8-6-11(18)7-9-12)17(22)13-4-3-5-14(20)16(13)19/h3-10H,1-2H3/b15-10+
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n/an/an/an/a 0.262n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM351018
PNG
(6-[4-[(1-Acetyl-4-piperidyl)methyl]-1H-pyrazol-3-y...)
Show SMILES CN1C(=O)CCc2cc(ccc12)-c1n[nH]cc1CC1CCN(CC1)C(C)=O
Show InChI InChI=1S/C21H26N4O2/c1-14(26)25-9-7-15(8-10-25)11-18-13-22-23-21(18)17-3-5-19-16(12-17)4-6-20(27)24(19)2/h3,5,12-13,15H,4,6-11H2,1-2H3,(H,22,23)
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n/an/an/an/a 0.266n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...


US Patent US9796702 (2017)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2DB840G
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347732
PNG
(CHEM-US-00132 | US9790217, 55)
Show SMILES Clc1cc(COc2cccc(c2)-c2[nH]ncc2Oc2ccc(cc2)C#N)ccn1
Show InChI InChI=1S/C22H15ClN4O2/c23-21-10-16(8-9-25-21)14-28-19-3-1-2-17(11-19)22-20(13-26-27-22)29-18-6-4-15(12-24)5-7-18/h1-11,13H,14H2,(H,26,27)
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n/an/an/an/a 0.288n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM347715
PNG
(Methyl 3-[(Z)-2-(4-cyano-2-fluoro- phenoxy)-3-(dim...)
Show SMILES COC(=O)c1cccc(c1)C(=O)C(\Oc1ccc(cc1F)C#N)=C\N(C)C
Show InChI InChI=1S/C20H17FN2O4/c1-23(2)12-18(27-17-8-7-13(11-22)9-16(17)21)19(24)14-5-4-6-15(10-14)20(25)26-3/h4-10,12H,1-3H3/b18-12-
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n/an/an/an/a 0.321n/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...


US Patent US9790217 (2017)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2K64M6M
More data for this
Ligand-Target Pair
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