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Found 6729 hits Enz. Inhib. hit(s) with Target = 'D(3) dopamine receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50341508
PNG
((S)-N-(4-(4-Phenylbenzoylamino)butyl)-N-propyl-5-a...)
Show SMILES CCCN(CCCCNC(=O)c1ccc(cc1)-c1ccccc1)[C@H]1CCn2nccc2C1
Show InChI InChI=1S/C27H34N4O/c1-2-18-30(25-15-20-31-26(21-25)14-17-29-31)19-7-6-16-28-27(32)24-12-10-23(11-13-24)22-8-4-3-5-9-22/h3-5,8-14,17,25H,2,6-7,15-16,18-21H2,1H3,(H,28,32)/t25-/m0/s1
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n/an/an/an/a 0.00280n/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as induction of [3H]thymidine incorporation after 2 hrs


J Med Chem 54: 2477-91 (2011)


Article DOI: 10.1021/jm101639t
BindingDB Entry DOI: 10.7270/Q2V1253W
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50090828
PNG
((-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4-oxa-9-...)
Show SMILES CCCN1CCO[C@H]2[C@H]1CSc1ccc(O)cc21
Show InChI InChI=1S/C14H19NO2S/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15/h3-4,8,12,14,16H,2,5-7,9H2,1H3/t12-,14-/m1/s1
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n/an/an/an/a 0.00700n/an/an/an/a



University Centre for Pharmacy

Curated by ChEMBL


Assay Description
Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from rat


J Med Chem 43: 2871-82 (2000)


Article DOI: 10.1021/jm0000113
BindingDB Entry DOI: 10.7270/Q2X067R1
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50341508
PNG
((S)-N-(4-(4-Phenylbenzoylamino)butyl)-N-propyl-5-a...)
Show SMILES CCCN(CCCCNC(=O)c1ccc(cc1)-c1ccccc1)[C@H]1CCn2nccc2C1
Show InChI InChI=1S/C27H34N4O/c1-2-18-30(25-15-20-31-26(21-25)14-17-29-31)19-7-6-16-28-27(32)24-12-10-23(11-13-24)22-8-4-3-5-9-22/h3-5,8-14,17,25H,2,6-7,15-16,18-21H2,1H3,(H,28,32)/t25-/m0/s1
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n/an/an/an/a 0.0560n/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Agonist activity at human dopamine D3 receptor expressed in HEK293 cells co-expressing Galphao1 assessed as incorporation of [35S]GTPgammaS into Galp...


J Med Chem 54: 2477-91 (2011)


Article DOI: 10.1021/jm101639t
BindingDB Entry DOI: 10.7270/Q2V1253W
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50261279
PNG
((+)-N6-(2-(4-(2,3-Dichlorophenyl)piperazin-1-yl)et...)
Show SMILES CCCN(CCN1CCN(CC1)c1cccc(Cl)c1Cl)C1CCc2nc(N)sc2C1
Show InChI InChI=1S/C22H31Cl2N5S/c1-2-8-28(16-6-7-18-20(15-16)30-22(25)26-18)12-9-27-10-13-29(14-11-27)19-5-3-4-17(23)21(19)24/h3-5,16H,2,6-15H2,1H3,(H2,25,26)
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n/an/an/an/a 0.0600n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding


J Med Chem 51: 3005-19 (2008)


Article DOI: 10.1021/jm701524h
BindingDB Entry DOI: 10.7270/Q2BV7GD5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50229776
PNG
(6-[(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pr...)
Show SMILES CCCN(CCN1CCN(CC1)c1ccccc1OC)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C26H37N3O2/c1-3-13-28(22-11-12-23-21(20-22)7-6-9-25(23)30)17-14-27-15-18-29(19-16-27)24-8-4-5-10-26(24)31-2/h4-10,22,30H,3,11-20H2,1-2H3
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n/an/an/an/a 0.0800n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTPgammaS binding


J Med Chem 51: 101-17 (2008)


Article DOI: 10.1021/jm070860r
BindingDB Entry DOI: 10.7270/Q2VQ32FD
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50261383
PNG
((-)-N6-(2-(4-(Biphenyl-4-yl)piperazin-1-yl)-ethyl)...)
Show SMILES CCCN(CCN1CCN(CC1)c1ccc(cc1)-c1ccccc1)C1CCc2nc(N)sc2C1
Show InChI InChI=1S/C28H37N5S/c1-2-14-32(25-12-13-26-27(21-25)34-28(29)30-26)18-15-31-16-19-33(20-17-31)24-10-8-23(9-11-24)22-6-4-3-5-7-22/h3-11,25H,2,12-21H2,1H3,(H2,29,30)
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n/an/an/an/a 0.0850n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding


J Med Chem 51: 3005-19 (2008)


Article DOI: 10.1021/jm701524h
BindingDB Entry DOI: 10.7270/Q2BV7GD5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50273996
PNG
((S)-N*6*-[2-(4-Biphenyl-4-yl-piperazin-1-yl)-ethyl...)
Show SMILES CCCN(CCN1CCN(CC1)c1ccc(cc1)-c1ccccc1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C28H37N5S/c1-2-14-32(25-12-13-26-27(21-25)34-28(29)30-26)18-15-31-16-19-33(20-17-31)24-10-8-23(9-11-24)22-6-4-3-5-7-22/h3-11,25H,2,12-21H2,1H3,(H2,29,30)/t25-/m0/s1
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n/an/an/an/a 0.0850n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding


J Med Chem 53: 1023-37 (2010)


Article DOI: 10.1021/jm901184n
BindingDB Entry DOI: 10.7270/Q29023VM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50229775
PNG
((+)-6-[(2-(4-phenylpiperazin-1-yl)ethyl)(propyl)am...)
Show SMILES CCCN(CCN1CCN(CC1)c1ccccc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C25H35N3O/c1-2-13-27(23-11-12-24-21(20-23)7-6-10-25(24)29)17-14-26-15-18-28(19-16-26)22-8-4-3-5-9-22/h3-10,23,29H,2,11-20H2,1H3
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n/an/an/an/a 0.120n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTPgammaS binding


J Med Chem 51: 101-17 (2008)


Article DOI: 10.1021/jm070860r
BindingDB Entry DOI: 10.7270/Q2VQ32FD
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50020221
PNG
((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...)
Show SMILES CCCN(CCC)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-8-9-15-13(12-14)6-5-7-16(15)18/h5-7,14,18H,3-4,8-12H2,1-2H3
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n/an/an/an/a 0.140n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding


Bioorg Med Chem 17: 3923-33 (2009)


Article DOI: 10.1016/j.bmc.2009.04.031
BindingDB Entry DOI: 10.7270/Q25H7G8C
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50184795
PNG
(1-(2-methoxyphenyl)-4-((1-phenyl-1H-pyrazol-4-yl)m...)
Show SMILES COc1ccccc1N1CCN(Cc2cnn(c2)-c2ccccc2)CC1
Show InChI InChI=1S/C21H24N4O/c1-26-21-10-6-5-9-20(21)24-13-11-23(12-14-24)16-18-15-22-25(17-18)19-7-3-2-4-8-19/h2-10,15,17H,11-14,16H2,1H3
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n/an/an/an/a 0.210n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Intrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assay


Bioorg Med Chem Lett 16: 2955-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.075
BindingDB Entry DOI: 10.7270/Q21N80QX
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50326731
PNG
((-)-6-((2-(4-(biphenyl-4-yl)piperazin-1-yl)ethyl)(...)
Show SMILES CCCN(CCN1CCN(CC1)c1ccc(cc1)-c1ccccc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C31H39N3O/c1-2-17-33(29-15-16-30-27(24-29)9-6-10-31(30)35)21-18-32-19-22-34(23-20-32)28-13-11-26(12-14-28)25-7-4-3-5-8-25/h3-14,29,35H,2,15-24H2,1H3
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n/an/an/an/a 0.25n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding


Bioorg Med Chem 18: 5661-74 (2010)


Article DOI: 10.1016/j.bmc.2010.06.025
BindingDB Entry DOI: 10.7270/Q2W37WJ9
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50392126
PNG
(CHEMBL2152747)
Show SMILES CCCN(CCN1CCN(CC1)C(=O)c1cc2ccccc2[nH]1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C25H34N6OS/c1-2-9-30(19-7-8-21-23(17-19)33-25(26)28-21)13-10-29-11-14-31(15-12-29)24(32)22-16-18-5-3-4-6-20(18)27-22/h3-6,16,19,27H,2,7-15,17H2,1H3,(H2,26,28)/t19-/m0/s1
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n/an/an/an/a 0.260n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


J Med Chem 55: 5826-40 (2012)


Article DOI: 10.1021/jm300268s
BindingDB Entry DOI: 10.7270/Q2NC629F
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50236334
PNG
(CHEMBL4071240)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NCCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c1
Show InChI InChI=1S/C28H30Cl2N4O3/c29-24-10-5-11-25(26(24)30)34-16-14-33(15-17-34)13-2-1-12-32-28(36)37-23-9-4-7-21(19-23)20-6-3-8-22(18-20)27(31)35/h3-11,18-19H,1-2,12-17H2,(H2,31,35)(H,32,36)
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n/an/an/an/a 0.302n/an/an/an/a



Universit£ di Bologna

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay


J Med Chem 60: 2287-2304 (2017)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50236965
PNG
(CHEMBL4069145)
Show SMILES COc1ccccc1N1CCN(CCCCOc2ccc3c(\C=N\O)cnn3c2)CC1
Show InChI InChI=1S/C23H29N5O3/c1-30-23-7-3-2-6-22(23)27-13-11-26(12-14-27)10-4-5-15-31-20-8-9-21-19(17-25-29)16-24-28(21)18-20/h2-3,6-9,16-18,29H,4-5,10-15H2,1H3/b25-17+
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n/an/an/an/a 0.320n/an/an/an/a



Friedrich-Alexander University Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins...


J Med Chem 60: 2908-2929 (2017)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50236965
PNG
(CHEMBL4069145)
Show SMILES COc1ccccc1N1CCN(CCCCOc2ccc3c(\C=N\O)cnn3c2)CC1
Show InChI InChI=1S/C23H29N5O3/c1-30-23-7-3-2-6-22(23)27-13-11-26(12-14-27)10-4-5-15-31-20-8-9-21-19(17-25-29)16-24-28(21)18-20/h2-3,6-9,16-18,29H,4-5,10-15H2,1H3/b25-17+
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n/an/an/an/a 0.324n/an/an/an/a



Friedrich-Alexander University Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins...


J Med Chem 60: 2908-2929 (2017)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50342710
PNG
(2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-2,3...)
Show SMILES COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1
Show InChI InChI=1S/C25H33N3O2/c1-30-24-13-5-4-12-23(24)27-19-17-26(18-20-27)14-6-7-15-28-16-8-10-21-9-2-3-11-22(21)25(28)29/h2-5,9,11-13H,6-8,10,14-20H2,1H3
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n/an/an/an/a 0.330n/an/an/an/a



University of Santiago de Compostela

Curated by ChEMBL


Assay Description
Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation


Bioorg Med Chem Lett 21: 2670-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.083
BindingDB Entry DOI: 10.7270/Q2GF0TT4
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50010586
PNG
((+)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-diox...)
Show SMILES CCCN1CCO[C@H]2[C@H]1COc1ccc(O)cc21
Show InChI InChI=1S/C14H19NO3/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15/h3-4,8,12,14,16H,2,5-7,9H2,1H3/t12-,14-/m1/s1
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n/an/an/an/a 0.360n/an/an/an/a



University Centre for Pharmacy

Curated by ChEMBL


Assay Description
Agonist activity by measuring the [3H]-thymidine uptake against Dopamine receptor D3 from rat


J Med Chem 43: 2871-82 (2000)


Article DOI: 10.1021/jm0000113
BindingDB Entry DOI: 10.7270/Q2X067R1
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50119386
PNG
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1
Show InChI InChI=1S/C24H29N3O2S/c1-29-21-10-4-3-9-20(21)27-16-14-26(15-17-27)13-7-6-12-25-24(28)23-18-19-8-2-5-11-22(19)30-23/h2-5,8-11,18H,6-7,12-17H2,1H3,(H,25,28)
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n/an/an/an/a 0.360n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells


J Med Chem 45: 4594-7 (2002)


Article DOI: 10.1021/jm025558r
BindingDB Entry DOI: 10.7270/Q2DR2W7K
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50236740
PNG
(CHEMBL4078348)
Show SMILES CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1
Show InChI InChI=1S/C24H31N3O2/c1-2-13-26(20-8-9-23-19(17-20)6-5-7-24(23)28)14-3-4-16-29-22-11-15-27-21(18-22)10-12-25-27/h5-7,10-12,15,18,20,28H,2-4,8-9,13-14,16-17H2,1H3/t20-/m0/s1
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n/an/an/an/a 0.427n/an/an/an/a



Friedrich-Alexander University Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against LPS- induced TNF-alpha production in whole human blood assay


J Med Chem 60: 2908-2929 (2017)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50236740
PNG
(CHEMBL4078348)
Show SMILES CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1
Show InChI InChI=1S/C24H31N3O2/c1-2-13-26(20-8-9-23-19(17-20)6-5-7-24(23)28)14-3-4-16-29-22-11-15-27-21(18-22)10-12-25-27/h5-7,10-12,15,18,20,28H,2-4,8-9,13-14,16-17H2,1H3/t20-/m0/s1
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n/an/an/an/a 0.430n/an/an/an/a



Friedrich-Alexander University Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against LPS- induced TNF-alpha production in whole human blood assay


J Med Chem 60: 2908-2929 (2017)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50237166
PNG
(CHEMBL4097330)
Show SMILES CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1
Show InChI InChI=1S/C24H31N3O2/c1-2-14-26(21-9-11-23-19(17-21)6-5-7-24(23)28)15-3-4-16-29-22-10-8-20-12-13-25-27(20)18-22/h5-8,10,12-13,18,21,28H,2-4,9,11,14-17H2,1H3/t21-/m0/s1
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n/an/an/an/a 0.479n/an/an/an/a



Friedrich-Alexander University Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins...


J Med Chem 60: 2908-2929 (2017)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50237166
PNG
(CHEMBL4097330)
Show SMILES CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1
Show InChI InChI=1S/C24H31N3O2/c1-2-14-26(21-9-11-23-19(17-21)6-5-7-24(23)28)15-3-4-16-29-22-10-8-20-12-13-25-27(20)18-22/h5-8,10,12-13,18,21,28H,2-4,9,11,14-17H2,1H3/t21-/m0/s1
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n/an/an/an/a 0.480n/an/an/an/a



Friedrich-Alexander University Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins...


J Med Chem 60: 2908-2929 (2017)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50303792
PNG
((-)-(S)-N6-Propyl-N6-(2-(4-(quinolin-4-yl)piperazi...)
Show SMILES CCCN(CCN1CCN(CC1)c1ccnc2ccccc12)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C25H34N6S/c1-2-11-30(19-7-8-22-24(18-19)32-25(26)28-22)15-12-29-13-16-31(17-14-29)23-9-10-27-21-6-4-3-5-20(21)23/h3-6,9-10,19H,2,7-8,11-18H2,1H3,(H2,26,28)/t19-/m0/s1
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n/an/an/an/a 0.493n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding


J Med Chem 53: 1023-37 (2010)


Article DOI: 10.1021/jm901184n
BindingDB Entry DOI: 10.7270/Q29023VM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50303791
PNG
((-)-(S)-N6-(2-(4-(Isoquinolin-1-yl)piperazin-1-yl)...)
Show SMILES CCCN(CCN1CCN(CC1)c1nccc2ccccc12)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C25H34N6S/c1-2-11-30(20-7-8-22-23(18-20)32-25(26)28-22)15-12-29-13-16-31(17-14-29)24-21-6-4-3-5-19(21)9-10-27-24/h3-6,9-10,20H,2,7-8,11-18H2,1H3,(H2,26,28)/t20-/m0/s1
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n/an/an/an/a 0.520n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding


J Med Chem 53: 1023-37 (2010)


Article DOI: 10.1021/jm901184n
BindingDB Entry DOI: 10.7270/Q29023VM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50303794
PNG
((-)-(S)-N6-Propyl-N6-(2-(4-(quinolin-5-yl)piperazi...)
Show SMILES CCCN(CCN1CCN(CC1)c1cccc2ncccc12)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C25H34N6S/c1-2-11-30(19-8-9-22-24(18-19)32-25(26)28-22)15-12-29-13-16-31(17-14-29)23-7-3-6-21-20(23)5-4-10-27-21/h3-7,10,19H,2,8-9,11-18H2,1H3,(H2,26,28)/t19-/m0/s1
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n/an/an/an/a 0.528n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding


J Med Chem 53: 1023-37 (2010)


Article DOI: 10.1021/jm901184n
BindingDB Entry DOI: 10.7270/Q29023VM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50400590
PNG
(CHEMBL2206264)
Show SMILES CCCN(CCCCCCCCCN(CCC)[C@H]1CCc2c(O)cccc2C1)[C@H]1CCc2c(O)cccc2C1
Show InChI InChI=1S/C35H54N2O2/c1-3-22-36(30-18-20-32-28(26-30)14-12-16-34(32)38)24-10-8-6-5-7-9-11-25-37(23-4-2)31-19-21-33-29(27-31)15-13-17-35(33)39/h12-17,30-31,38-39H,3-11,18-27H2,1-2H3/t30-,31-/m0/s1
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n/an/an/an/a 0.530n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay


ACS Med Chem Lett 3: 991-996 (2012)


Article DOI: 10.1021/ml3002117
BindingDB Entry DOI: 10.7270/Q26M3804
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50020222
PNG
((+/-)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthal...)
Show SMILES CCCN(CCC)C1CCc2ccc(O)cc2C1
Show InChI InChI=1S/C16H25NO/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3
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n/an/an/an/a 0.531n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding


J Med Chem 51: 3005-19 (2008)


Article DOI: 10.1021/jm701524h
BindingDB Entry DOI: 10.7270/Q2BV7GD5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50392134
PNG
(CHEMBL2152755)
Show SMILES CCCN(CCN1CCN(CC1)C(=O)c1ccc2[nH]ccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C25H34N6OS/c1-2-9-30(20-4-6-22-23(17-20)33-25(26)28-22)13-10-29-11-14-31(15-12-29)24(32)19-3-5-21-18(16-19)7-8-27-21/h3,5,7-8,16,20,27H,2,4,6,9-15,17H2,1H3,(H2,26,28)/t20-/m0/s1
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n/an/an/an/a 0.560n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


J Med Chem 55: 5826-40 (2012)


Article DOI: 10.1021/jm300268s
BindingDB Entry DOI: 10.7270/Q2NC629F
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50115277
PNG
((2R,3R)-6-Dipropylamino-5,6,7,8-tetrahydro-naphtha...)
Show SMILES CCCN(CCC)[C@H]1CCc2c(O)cccc2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-8-9-15-13(12-14)6-5-7-16(15)18/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m0/s1
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n/an/an/an/a 0.630n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay


ACS Med Chem Lett 3: 991-996 (2012)


Article DOI: 10.1021/ml3002117
BindingDB Entry DOI: 10.7270/Q26M3804
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50109926
PNG
(7-((2-(4-phenylpiperazin-1-yl)ethyl)(propyl)amino)...)
Show SMILES CCCN(CCN1CCN(CC1)c1ccccc1)C1CCc2ccc(O)cc2C1
Show InChI InChI=1S/C25H35N3O/c1-2-12-27(24-10-8-21-9-11-25(29)20-22(21)19-24)16-13-26-14-17-28(18-15-26)23-6-4-3-5-7-23/h3-7,9,11,20,24,29H,2,8,10,12-19H2,1H3
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n/an/an/an/a 0.690n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTPgammaS binding


J Med Chem 51: 101-17 (2008)


Article DOI: 10.1021/jm070860r
BindingDB Entry DOI: 10.7270/Q2VQ32FD
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM84889
PNG
(THC, 11-OH-delta 8 | THC-DMH, (+)-11-OH)
Show SMILES CCCCCCC(C)(C)c1cc(O)c2[C@@H]3C=C(CO)CC[C@H]3C(C)(C)Oc2c1
Show InChI InChI=1S/C25H38O3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h13-15,19-20,26-27H,6-12,16H2,1-5H3/t19-,20-/m1/s1
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n/an/an/an/a 0.730n/an/an/an/a



Universit£ di Bologna

Curated by ChEMBL


Assay Description
Inhibitory concentration was evaluated against Farnesyltransferase in the farnesylation of H-ras protein


J Med Chem 60: 2287-2304 (2017)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50307833
PNG
((+)-4-(4-(2-((7-Hydroxy-1,2,3,4-tetrahydronaphthal...)
Show SMILES CCCN(CCN1CCN(CC1)c1ccnc2c(O)cccc12)C1CCc2ccc(O)cc2C1
Show InChI InChI=1S/C28H36N4O2/c1-2-12-31(23-8-6-21-7-9-24(33)20-22(21)19-23)16-13-30-14-17-32(18-15-30)26-10-11-29-28-25(26)4-3-5-27(28)34/h3-5,7,9-11,20,23,33-34H,2,6,8,12-19H2,1H3
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n/an/an/an/a 0.740n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


J Med Chem 53: 2114-25 (2010)


Article DOI: 10.1021/jm901618d
BindingDB Entry DOI: 10.7270/Q20K28QZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50056446
PNG
((R)-5-Propylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Show SMILES CCCN[C@@H]1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C13H17N3O/c1-2-6-14-10-7-9-4-3-5-11-12(9)16(8-10)13(17)15-11/h3-5,10,14H,2,6-8H2,1H3,(H,15,17)/t10-/m1/s1
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n/an/an/an/a 0.810n/an/an/an/a



Columbia University College of Physicians and Surgeons

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human D3 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]t...


J Med Chem 59: 2973-88 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01612
BindingDB Entry DOI: 10.7270/Q2708393
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50303791
PNG
((-)-(S)-N6-(2-(4-(Isoquinolin-1-yl)piperazin-1-yl)...)
Show SMILES CCCN(CCN1CCN(CC1)c1nccc2ccccc12)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C25H34N6S/c1-2-11-30(20-7-8-22-23(18-20)32-25(26)28-22)15-12-29-13-16-31(17-14-29)24-21-6-4-3-5-19(21)9-10-27-24/h3-6,9-10,20H,2,7-8,11-18H2,1H3,(H2,26,28)/t20-/m0/s1
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n/an/an/an/a 0.820n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


J Med Chem 55: 5826-40 (2012)


Article DOI: 10.1021/jm300268s
BindingDB Entry DOI: 10.7270/Q2NC629F
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50392131
PNG
(CHEMBL2152752)
Show SMILES CCCN(CCN1CCN(CC1)C(=O)c1c[nH]c2ccccc12)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C25H34N6OS/c1-2-9-30(18-7-8-22-23(16-18)33-25(26)28-22)13-10-29-11-14-31(15-12-29)24(32)20-17-27-21-6-4-3-5-19(20)21/h3-6,17-18,27H,2,7-16H2,1H3,(H2,26,28)/t18-/m0/s1
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n/an/an/an/a 0.870n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


J Med Chem 55: 5826-40 (2012)


Article DOI: 10.1021/jm300268s
BindingDB Entry DOI: 10.7270/Q2NC629F
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50236331
PNG
(CHEMBL4091498)
Show SMILES NC(=O)c1cccc(c1)-c1ccc(OC(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)cc1
Show InChI InChI=1S/C27H28Cl2N4O3/c28-23-6-2-7-24(25(23)29)33-16-14-32(15-17-33)13-3-12-31-27(35)36-22-10-8-19(9-11-22)20-4-1-5-21(18-20)26(30)34/h1-2,4-11,18H,3,12-17H2,(H2,30,34)(H,31,35)
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n/an/an/an/a 0.900n/an/an/an/a



Universit£ di Bologna

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF ...


J Med Chem 60: 2287-2304 (2017)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50236334
PNG
(CHEMBL4071240)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NCCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c1
Show InChI InChI=1S/C28H30Cl2N4O3/c29-24-10-5-11-25(26(24)30)34-16-14-33(15-17-34)13-2-1-12-32-28(36)37-23-9-4-7-21(19-23)20-6-3-8-22(18-20)27(31)35/h3-11,18-19H,1-2,12-17H2,(H2,31,35)(H,32,36)
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n/an/an/an/a 0.900n/an/an/an/a



Universit£ di Bologna

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay


J Med Chem 60: 2287-2304 (2017)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50236338
PNG
(CHEMBL4099236)
Show SMILES Cl.COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(cc2)-c2cccc(c2)C(N)=O)CC1
Show InChI InChI=1S/C29H34N4O4.ClH/c1-36-27-10-3-2-9-26(27)33-19-17-32(18-20-33)16-5-4-15-31-29(35)37-25-13-11-22(12-14-25)23-7-6-8-24(21-23)28(30)34;/h2-3,6-14,21H,4-5,15-20H2,1H3,(H2,30,34)(H,31,35);1H
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n/an/an/an/a 0.900n/an/an/an/a



Universit£ di Bologna

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF ...


J Med Chem 60: 2287-2304 (2017)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50236330
PNG
(CHEMBL4070196)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c1
Show InChI InChI=1S/C27H28Cl2N4O3/c28-23-9-3-10-24(25(23)29)33-15-13-32(14-16-33)12-4-11-31-27(35)36-22-8-2-6-20(18-22)19-5-1-7-21(17-19)26(30)34/h1-3,5-10,17-18H,4,11-16H2,(H2,30,34)(H,31,35)
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n/an/an/an/a 0.912n/an/an/an/a



Universit£ di Bologna

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay


J Med Chem 60: 2287-2304 (2017)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50400589
PNG
(CHEMBL2206265)
Show SMILES CCCN(CCCCCCCCCCN(CCC)[C@H]1CCc2c(O)cccc2C1)[C@H]1CCc2c(O)cccc2C1
Show InChI InChI=1S/C36H56N2O2/c1-3-23-37(31-19-21-33-29(27-31)15-13-17-35(33)39)25-11-9-7-5-6-8-10-12-26-38(24-4-2)32-20-22-34-30(28-32)16-14-18-36(34)40/h13-18,31-32,39-40H,3-12,19-28H2,1-2H3/t31-,32-/m0/s1
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n/an/an/an/a 0.940n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay


ACS Med Chem Lett 3: 991-996 (2012)


Article DOI: 10.1021/ml3002117
BindingDB Entry DOI: 10.7270/Q26M3804
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50104924
PNG
(CHEMBL3597649)
Show SMILES COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cnc3ccccc3c2)CC1
Show InChI InChI=1S/C25H30N4O3/c1-32-24-9-5-4-8-23(24)29-14-12-28(13-15-29)18-21(30)10-11-26-25(31)20-16-19-6-2-3-7-22(19)27-17-20/h2-9,16-17,21,30H,10-15,18H2,1H3,(H,26,31)
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n/an/an/an/a 0.950n/an/an/an/a



National Institute on Drug Abuse- Intramural Research Program

Curated by ChEMBL


Assay Description
Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of quinpirole-stimulated mitogenesis


J Med Chem 58: 6195-213 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00776
BindingDB Entry DOI: 10.7270/Q2KS6T92
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50020222
PNG
((+/-)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthal...)
Show SMILES CCCN(CCC)C1CCc2ccc(O)cc2C1
Show InChI InChI=1S/C16H25NO/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3
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n/an/an/an/a 0.950n/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Agonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based...


Bioorg Med Chem 20: 6366-74 (2012)


Article DOI: 10.1016/j.bmc.2012.08.058
BindingDB Entry DOI: 10.7270/Q2G161X3
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50016017
PNG
((5aR,9aR)-6-Propyl-5,5a,6,7,8,9,9a,10-octahydro-py...)
Show SMILES CCCN1CCC[C@@H]2Cc3nc(N)ncc3C[C@@H]12
Show InChI InChI=1S/C14H22N4/c1-2-5-18-6-3-4-10-7-12-11(8-13(10)18)9-16-14(15)17-12/h9-10,13H,2-8H2,1H3,(H2,15,16,17)/t10-,13-/m1/s1
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n/an/an/an/a 1n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation


Bioorg Med Chem Lett 17: 6691-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.10.059
BindingDB Entry DOI: 10.7270/Q23J3CQ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50219110
PNG
(CHEMBL244990 | N-(4-(4-(2,3-dichlorophenyl)piperaz...)
Show SMILES OC(CCNC(=O)c1ccc(cc1)-c1ccccn1)CN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C26H28Cl2N4O2/c27-22-4-3-6-24(25(22)28)32-16-14-31(15-17-32)18-21(33)11-13-30-26(34)20-9-7-19(8-10-20)23-5-1-2-12-29-23/h1-10,12,21,33H,11,13-18H2,(H,30,34)
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n/an/an/an/a 1n/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay


J Med Chem 50: 4135-46 (2007)


Article DOI: 10.1021/jm0704200
BindingDB Entry DOI: 10.7270/Q2WW7HDW
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50236330
PNG
(CHEMBL4070196)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c1
Show InChI InChI=1S/C27H28Cl2N4O3/c28-23-9-3-10-24(25(23)29)33-15-13-32(14-16-33)12-4-11-31-27(35)36-22-8-2-6-20(18-22)19-5-1-7-21(17-19)26(30)34/h1-3,5-10,17-18H,4,11-16H2,(H2,30,34)(H,31,35)
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n/an/an/an/a 1n/an/an/an/a



Universit£ di Bologna

Curated by ChEMBL


Assay Description
Inhibitory concentration was evaluated against Farnesyltransferase in the farnesylation of H-ras protein


J Med Chem 60: 2287-2304 (2017)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50236333
PNG
(CHEMBL4092052)
Show SMILES NC(=O)c1cccc(c1)-c1ccc(OC(=O)NCCCCN2CCN(CC2)c2cccc(Cl)c2Cl)cc1
Show InChI InChI=1S/C28H30Cl2N4O3/c29-24-7-4-8-25(26(24)30)34-17-15-33(16-18-34)14-2-1-13-32-28(36)37-23-11-9-20(10-12-23)21-5-3-6-22(19-21)27(31)35/h3-12,19H,1-2,13-18H2,(H2,31,35)(H,32,36)
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n/an/an/an/a 1n/an/an/an/a



Universit£ di Bologna

Curated by ChEMBL


Assay Description
Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-ras


J Med Chem 60: 2287-2304 (2017)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50326734
PNG
(7-((2-(4-(biphenyl-4-yl)piperazin-1-yl)ethyl)(prop...)
Show SMILES CCCN(CCN1CCN(CC1)c1ccc(cc1)-c1ccccc1)C1CCc2ccc(O)cc2C1
Show InChI InChI=1S/C31H39N3O/c1-2-16-33(30-14-10-27-11-15-31(35)24-28(27)23-30)20-17-32-18-21-34(22-19-32)29-12-8-26(9-13-29)25-6-4-3-5-7-25/h3-9,11-13,15,24,30,35H,2,10,14,16-23H2,1H3
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n/an/an/an/a 1.03n/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding


Bioorg Med Chem 18: 5661-74 (2010)


Article DOI: 10.1016/j.bmc.2010.06.025
BindingDB Entry DOI: 10.7270/Q2W37WJ9
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50105731
PNG
((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...)
Show SMILES CCCN(CCC)[C@H]1CCn2c(C1)ccc2C=O
Show InChI InChI=1S/C15H24N2O/c1-3-8-16(9-4-2)13-7-10-17-14(11-13)5-6-15(17)12-18/h5-6,12-13H,3-4,7-11H2,1-2H3/t13-/m0/s1
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n/an/an/an/a 1.10n/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Effective concentration against dopamine D3 receptor


J Med Chem 48: 5771-9 (2005)


Article DOI: 10.1021/jm0503805
BindingDB Entry DOI: 10.7270/Q2KW5GT9
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50105731
PNG
((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...)
Show SMILES CCCN(CCC)[C@H]1CCn2c(C1)ccc2C=O
Show InChI InChI=1S/C15H24N2O/c1-3-8-16(9-4-2)13-7-10-17-14(11-13)5-6-15(17)12-18/h5-6,12-13H,3-4,7-11H2,1-2H3/t13-/m0/s1
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n/an/an/an/a 1.10n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Effective concentration to stimulate human Dopamine receptor D3 mediated [3H]-thymidine incorporation into growing cells using mitogenesis assay


J Med Chem 48: 2493-508 (2005)


Article DOI: 10.1021/jm049269+
BindingDB Entry DOI: 10.7270/Q2TT4QGT
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50007179
PNG
(4-Iodo-N-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)cc2)CC1
Show InChI InChI=1S/C22H28IN3O2/c1-28-21-7-3-2-6-20(21)26-16-14-25(15-17-26)13-5-4-12-24-22(27)18-8-10-19(23)11-9-18/h2-3,6-11H,4-5,12-17H2,1H3,(H,24,27)
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n/an/an/an/a 1.20n/an/an/an/a



Johann Wolfgang Goethe-Universität

Curated by ChEMBL


Assay Description
Effective concentration of the compound for Dopamine receptor D3 was determined


J Med Chem 46: 3883-99 (2003)


Article DOI: 10.1021/jm030836n
BindingDB Entry DOI: 10.7270/Q23F4P18
More data for this
Ligand-Target Pair
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