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Compile Data Set for Download or QSAR

Found 1497 hits Enz. Inhib. hit(s) with Target = 'Dopamine receptors; D1 & D2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptors; D1 & D2


(RAT)
BDBM81195
PNG
((+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaph...)
Show SMILES NC1CCc2cc(O)c(O)cc2C1
Show InChI InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2
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n/an/an/an/a 1.30n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Renin


J Med Chem 28: 1803-10 (1985)


Article DOI: 10.1021/jm00150a010
More data for this
Ligand-Target Pair
Dopamine receptors; D1 & D2


(RAT)
BDBM50007148
PNG
(1-Aminomethyl-3-cyclohexyl-isochroman-5,6-diol | C...)
Show SMILES NC[C@@H]1OC(Cc2c(O)c(O)ccc12)C1CCCCC1
Show InChI InChI=1S/C16H23NO3/c17-9-15-11-6-7-13(18)16(19)12(11)8-14(20-15)10-4-2-1-3-5-10/h6-7,10,14-15,18-19H,1-5,8-9,17H2/t14?,15-/m0/s1
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n/an/an/an/a 1.70n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum


J Med Chem 34: 2561-9 (1991)


Article DOI: 10.1021/jm00112a034
BindingDB Entry DOI: 10.7270/Q2HM57DN
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50007129
PNG
((1R,3S)-1-Aminomethyl-3-phenyl-isochroman-5,6-diol...)
Show SMILES NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)c1ccccc1
Show InChI InChI=1S/C16H17NO3/c17-9-15-11-6-7-13(18)16(19)12(11)8-14(20-15)10-4-2-1-3-5-10/h1-7,14-15,18-19H,8-9,17H2/t14-,15-/m0/s1
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n/an/an/an/a 1.95n/an/an/an/a



University of North Carolina

Curated by ChEMBL


Assay Description
Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...


J Med Chem 39: 285-96 (1996)


Article DOI: 10.1021/jm9502100
BindingDB Entry DOI: 10.7270/Q2NZ86Q3
More data for this
Ligand-Target Pair
Dopamine receptors; D1 & D2


(RAT)
BDBM55121
PNG
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)
Show SMILES NCCc1ccc(O)c(O)c1
Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
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n/an/an/an/a 3.5n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human plasma renin


J Med Chem 28: 1803-10 (1985)


Article DOI: 10.1021/jm00150a010
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50033116
PNG
((1R,3S)-3-Adamantan-1-yl-1-aminomethyl-isochroman-...)
Show SMILES NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C20H27NO3/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20/h1-2,11-13,17-18,22-23H,3-10,21H2/t11?,12?,13?,17-,18-,20?/m0/s1
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n/an/an/an/a 5.10n/an/an/an/a



University of North Carolina

Curated by ChEMBL


Assay Description
Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...


J Med Chem 39: 285-96 (1996)


Article DOI: 10.1021/jm9502100
BindingDB Entry DOI: 10.7270/Q2NZ86Q3
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50007134
PNG
(1-Aminomethyl-3-phenyl-isochroman-5,6-diol | CHEMB...)
Show SMILES NC[C@@H]1OC(Cc2c(O)c(O)ccc12)c1ccccc1
Show InChI InChI=1S/C16H17NO3/c17-9-15-11-6-7-13(18)16(19)12(11)8-14(20-15)10-4-2-1-3-5-10/h1-7,14-15,18-19H,8-9,17H2/t14?,15-/m0/s1
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n/an/an/an/a 7.10n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum


J Med Chem 34: 2561-9 (1991)


Article DOI: 10.1021/jm00112a034
BindingDB Entry DOI: 10.7270/Q2HM57DN
More data for this
Ligand-Target Pair
Dopamine receptors; D1 & D2


(RAT)
BDBM50007147
PNG
(3-Adamantan-1-yl-1-aminomethyl-isochroman-5,6-diol...)
Show SMILES NC[C@@H]1OC(Cc2c(O)c(O)ccc12)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2
Show InChI InChI=1S/C20H27NO3/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20/h1-2,11-13,17-18,22-23H,3-10,21H2/t11-,12+,13-,17-,18?,20?/m0/s1
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n/an/an/an/a 8.30n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity using [3H]-spiperone radioligand competitive binding assay against dopamine receptor D2


J Med Chem 34: 2561-9 (1991)


Article DOI: 10.1021/jm00112a034
BindingDB Entry DOI: 10.7270/Q2HM57DN
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50019389
PNG
(3-Allyl-6-chloro-1-(4-hydroxy-phenyl)-2,3,4,5-tetr...)
Show SMILES Oc1ccc(cc1)C1CN(CC=C)CCc2c(Cl)c(O)c(O)cc12
Show InChI InChI=1S/C19H20ClNO3/c1-2-8-21-9-7-14-15(10-17(23)19(24)18(14)20)16(11-21)12-3-5-13(22)6-4-12/h2-6,10,16,22-24H,1,7-9,11H2
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n/an/an/an/a 15n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...


J Med Chem 30: 35-40 (1987)


Article DOI: 10.1021/jm00384a006
BindingDB Entry DOI: 10.7270/Q2X92BV6
More data for this
Ligand-Target Pair
Dopamine receptors; D1 & D2


(RAT)
BDBM50007128
PNG
(1-Aminomethyl-3-phenethyl-isochroman-5,6-diol | CH...)
Show SMILES NC[C@@H]1OC(CCc2ccccc2)Cc2c(O)c(O)ccc12
Show InChI InChI=1S/C18H21NO3/c19-11-17-14-8-9-16(20)18(21)15(14)10-13(22-17)7-6-12-4-2-1-3-5-12/h1-5,8-9,13,17,20-21H,6-7,10-11,19H2/t13?,17-/m0/s1
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n/an/an/an/a 19n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1


J Med Chem 34: 2561-9 (1991)


Article DOI: 10.1021/jm00112a034
BindingDB Entry DOI: 10.7270/Q2HM57DN
More data for this
Ligand-Target Pair
Dopamine receptors; D1 & D2


(RAT)
BDBM50007146
PNG
(1-Aminomethyl-3-hexyl-isochroman-5,6-diol | CHEMBL...)
Show SMILES CCCCCCC1Cc2c(O)c(O)ccc2[C@H](CN)O1
Show InChI InChI=1S/C16H25NO3/c1-2-3-4-5-6-11-9-13-12(15(10-17)20-11)7-8-14(18)16(13)19/h7-8,11,15,18-19H,2-6,9-10,17H2,1H3/t11?,15-/m0/s1
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n/an/an/an/a 23n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum


J Med Chem 34: 2561-9 (1991)


Article DOI: 10.1021/jm00112a034
BindingDB Entry DOI: 10.7270/Q2HM57DN
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50004918
PNG
((+/-)-APD3-Allyl-1-phenyl-2,3,4,5-tetrahydro-1H-be...)
Show SMILES Oc1cc2CCN(CC=C)CC(c3ccccc3)c2cc1O
Show InChI InChI=1S/C19H21NO2/c1-2-9-20-10-8-15-11-18(21)19(22)12-16(15)17(13-20)14-6-4-3-5-7-14/h2-7,11-12,17,21-22H,1,8-10,13H2
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n/an/an/an/a 25n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...


J Med Chem 30: 35-40 (1987)


Article DOI: 10.1021/jm00384a006
BindingDB Entry DOI: 10.7270/Q2X92BV6
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50010686
PNG
((6aR,12bS)-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydr...)
Show SMILES Oc1cc2CC[C@H]3NCc4ccccc4[C@@H]3c2cc1O
Show InChI InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17-/m1/s1
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n/an/an/an/a 30n/an/an/an/a



University of North Carolina

Curated by ChEMBL


Assay Description
Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...


J Med Chem 39: 285-96 (1996)


Article DOI: 10.1021/jm9502100
BindingDB Entry DOI: 10.7270/Q2NZ86Q3
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50007140
PNG
(1-Allylaminomethyl-3-cyclohexyl-isochroman-5,6-dio...)
Show SMILES Oc1ccc2[C@H](CNCC=C)OC(Cc2c1O)C1CCCCC1
Show InChI InChI=1S/C19H27NO3/c1-2-10-20-12-18-14-8-9-16(21)19(22)15(14)11-17(23-18)13-6-4-3-5-7-13/h2,8-9,13,17-18,20-22H,1,3-7,10-12H2/t17?,18-/m0/s1
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n/an/an/an/a 30n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum


J Med Chem 34: 2561-9 (1991)


Article DOI: 10.1021/jm00112a034
BindingDB Entry DOI: 10.7270/Q2HM57DN
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50007130
PNG
(1-Aminomethyl-3-phenoxymethyl-isochroman-5,6-diol ...)
Show SMILES NC[C@@H]1OC(COc2ccccc2)Cc2c(O)c(O)ccc12
Show InChI InChI=1S/C17H19NO4/c18-9-16-13-6-7-15(19)17(20)14(13)8-12(22-16)10-21-11-4-2-1-3-5-11/h1-7,12,16,19-20H,8-10,18H2/t12?,16-/m0/s1
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n/an/an/an/a 40n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum


J Med Chem 34: 2561-9 (1991)


Article DOI: 10.1021/jm00112a034
BindingDB Entry DOI: 10.7270/Q2HM57DN
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50025696
PNG
(3-Allyl-6-bromo-1-(4-hydroxy-phenyl)-2,3,4,5-tetra...)
Show SMILES Oc1ccc(cc1)C1CN(CC=C)CCc2c(Br)c(O)c(O)cc12
Show InChI InChI=1S/C19H20BrNO3/c1-2-8-21-9-7-14-15(10-17(23)19(24)18(14)20)16(11-21)12-3-5-13(22)6-4-12/h2-6,10,16,22-24H,1,7-9,11H2
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n/an/an/an/a 50n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...


J Med Chem 30: 35-40 (1987)


Article DOI: 10.1021/jm00384a006
BindingDB Entry DOI: 10.7270/Q2X92BV6
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50007126
PNG
(1-Aminomethyl-3-tert-butyl-isochroman-5,6-diol | C...)
Show SMILES CC(C)(C)C1Cc2c(O)c(O)ccc2[C@H](CN)O1
Show InChI InChI=1S/C14H21NO3/c1-14(2,3)12-6-9-8(11(7-15)18-12)4-5-10(16)13(9)17/h4-5,11-12,16-17H,6-7,15H2,1-3H3/t11-,12?/m0/s1
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n/an/an/an/a 52n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum


J Med Chem 34: 2561-9 (1991)


Article DOI: 10.1021/jm00112a034
BindingDB Entry DOI: 10.7270/Q2HM57DN
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM60917
PNG
(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)
Show SMILES Oc1ccc(cc1)C1CNCCc2c(Cl)c(O)c(O)cc12
Show InChI InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2
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n/an/an/an/a 57n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes


J Med Chem 30: 1166-76 (1987)


Article DOI: 10.1021/jm00390a009
BindingDB Entry DOI: 10.7270/Q2028QJ6
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50004822
PNG
((R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine...)
Show SMILES Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O
Show InChI InChI=1S/C16H17NO2/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11/h1-5,8-9,14,17-19H,6-7,10H2/t14-/m1/s1
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n/an/an/an/a 100n/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Tested for its affinity towards Dopamine receptor D1 in rat striatal membrane


J Med Chem 37: 2453-60 (1994)


Article DOI: 10.1021/jm00041a025
BindingDB Entry DOI: 10.7270/Q2KS6QKD
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50025698
PNG
(3-Allyl-6-fluoro-1-(4-hydroxy-phenyl)-2,3,4,5-tetr...)
Show SMILES Oc1ccc(cc1)C1CN(CC=C)CCc2c(F)c(O)c(O)cc12
Show InChI InChI=1S/C19H20FNO3/c1-2-8-21-9-7-14-15(10-17(23)19(24)18(14)20)16(11-21)12-3-5-13(22)6-4-12/h2-6,10,16,22-24H,1,7-9,11H2
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TBA

Curated by ChEMBL


Assay Description
Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...


J Med Chem 30: 35-40 (1987)


Article DOI: 10.1021/jm00384a006
BindingDB Entry DOI: 10.7270/Q2X92BV6
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50020679
PNG
(7-(2-Amino-ethyl)-4-hydroxy-3H-benzothiazol-2-one ...)
Show SMILES NCCc1ccc(O)c2[nH]c(=O)sc12
Show InChI InChI=1S/C9H10N2O2S/c10-4-3-5-1-2-6(12)7-8(5)14-9(13)11-7/h1-2,12H,3-4,10H2,(H,11,13)
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n/an/an/an/a 295n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist...


J Med Chem 30: 1166-76 (1987)


Article DOI: 10.1021/jm00390a009
BindingDB Entry DOI: 10.7270/Q2028QJ6
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50025697
PNG
(3-Allyl-1-(4-hydroxy-phenyl)-2,3,4,5-tetrahydro-1H...)
Show SMILES Oc1ccc(cc1)C1CN(CC=C)CCc2cc(O)c(O)cc12
Show InChI InChI=1S/C19H21NO3/c1-2-8-20-9-7-14-10-18(22)19(23)11-16(14)17(12-20)13-3-5-15(21)6-4-13/h2-6,10-11,17,21-23H,1,7-9,12H2
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TBA

Curated by ChEMBL


Assay Description
Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...


J Med Chem 30: 35-40 (1987)


Article DOI: 10.1021/jm00384a006
BindingDB Entry DOI: 10.7270/Q2X92BV6
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50025695
PNG
(3-Allyl-1-(4-hydroxy-phenyl)-6-methyl-2,3,4,5-tetr...)
Show SMILES Cc1c(O)c(O)cc2C(CN(CC=C)CCc12)c1ccc(O)cc1
Show InChI InChI=1S/C20H23NO3/c1-3-9-21-10-8-16-13(2)20(24)19(23)11-17(16)18(12-21)14-4-6-15(22)7-5-14/h3-7,11,18,22-24H,1,8-10,12H2,2H3
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TBA

Curated by ChEMBL


Assay Description
Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...


J Med Chem 30: 35-40 (1987)


Article DOI: 10.1021/jm00384a006
BindingDB Entry DOI: 10.7270/Q2X92BV6
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50049048
PNG
((R)-3-Allyl-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1...)
Show SMILES Oc1cc2[C@H](CN(CC=C)CCc2c(Cl)c1O)c1ccccc1
Show InChI InChI=1S/C19H20ClNO2/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13/h2-7,11,16,22-23H,1,8-10,12H2/t16-/m1/s1
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n/an/an/an/a 491n/an/an/an/a



University of North Carolina

Curated by ChEMBL


Assay Description
Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...


J Med Chem 39: 285-96 (1996)


Article DOI: 10.1021/jm9502100
BindingDB Entry DOI: 10.7270/Q2NZ86Q3
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50010689
PNG
((S)-4-(4,5,6,7-Tetrahydro-thieno[2,3-c]pyridin-4-y...)
Show SMILES Oc1ccc(cc1O)[C@@H]1CNCc2sccc12
Show InChI InChI=1S/C13H13NO2S/c15-11-2-1-8(5-12(11)16)10-6-14-7-13-9(10)3-4-17-13/h1-5,10,14-16H,6-7H2/t10-/m0/s1
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n/an/an/an/a 700n/an/an/an/a



University of North Carolina

Curated by ChEMBL


Assay Description
Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...


J Med Chem 39: 285-96 (1996)


Article DOI: 10.1021/jm9502100
BindingDB Entry DOI: 10.7270/Q2NZ86Q3
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50049045
PNG
(6-Benzylamino-5,6,7,8-tetrahydro-naphthalene-1,2-d...)
Show SMILES Oc1ccc2CC(CCc2c1O)NCc1ccccc1
Show InChI InChI=1S/C17H19NO2/c19-16-9-6-13-10-14(7-8-15(13)17(16)20)18-11-12-4-2-1-3-5-12/h1-6,9,14,18-20H,7-8,10-11H2
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n/an/an/an/a 1.00E+3n/an/an/an/a



University of North Carolina

Curated by ChEMBL


Assay Description
Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...


J Med Chem 39: 285-96 (1996)


Article DOI: 10.1021/jm9502100
BindingDB Entry DOI: 10.7270/Q2NZ86Q3
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM55121
PNG
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)
Show SMILES NCCc1ccc(O)c(O)c1
Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
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n/an/an/an/a 3.50E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes


J Med Chem 30: 1166-76 (1987)


Article DOI: 10.1021/jm00390a009
BindingDB Entry DOI: 10.7270/Q2028QJ6
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50020686
PNG
(4-(2-Amino-ethyl)-7-hydroxy-1,3-dihydro-indol-2-on...)
Show SMILES NCCc1ccc(O)c2NC(=O)Cc12
Show InChI InChI=1S/C10H12N2O2/c11-4-3-6-1-2-8(13)10-7(6)5-9(14)12-10/h1-2,13H,3-5,11H2,(H,12,14)
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n/an/an/an/a 4.65E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist...


J Med Chem 30: 1166-76 (1987)


Article DOI: 10.1021/jm00390a009
BindingDB Entry DOI: 10.7270/Q2028QJ6
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM55121
PNG
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)
Show SMILES NCCc1ccc(O)c(O)c1
Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
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n/an/an/an/a 5.00E+3n/an/an/an/a



University of North Carolina

Curated by ChEMBL


Assay Description
Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...


J Med Chem 39: 285-96 (1996)


Article DOI: 10.1021/jm9502100
BindingDB Entry DOI: 10.7270/Q2NZ86Q3
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50010684
PNG
((6aR,12bS)-6-Propyl-5,6,6a,7,8,12b-hexahydro-benzo...)
Show SMILES CCCN1Cc2ccccc2[C@H]2[C@H]1CCc1cc(O)c(O)cc21
Show InChI InChI=1S/C20H23NO2/c1-2-9-21-12-14-5-3-4-6-15(14)20-16-11-19(23)18(22)10-13(16)7-8-17(20)21/h3-6,10-11,17,20,22-23H,2,7-9,12H2,1H3/t17-,20-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



University of North Carolina

Curated by ChEMBL


Assay Description
Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...


J Med Chem 39: 285-96 (1996)


Article DOI: 10.1021/jm9502100
BindingDB Entry DOI: 10.7270/Q2NZ86Q3
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50010688
PNG
(6-Benzylamino-5,6,7,8-tetrahydro-naphthalene-2,3-d...)
Show SMILES Oc1cc2CCC(Cc2cc1O)NCc1ccccc1
Show InChI InChI=1S/C17H19NO2/c19-16-9-13-6-7-15(8-14(13)10-17(16)20)18-11-12-4-2-1-3-5-12/h1-5,9-10,15,18-20H,6-8,11H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



University of North Carolina

Curated by ChEMBL


Assay Description
Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...


J Med Chem 39: 285-96 (1996)


Article DOI: 10.1021/jm9502100
BindingDB Entry DOI: 10.7270/Q2NZ86Q3
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50035644
PNG
((6aR,12bR)-6-Methyl-5,6,6a,7,8,12b-hexahydro-benzo...)
Show SMILES CN1Cc2ccccc2[C@H]2[C@H]1CCc1c(O)c(O)ccc21
Show InChI InChI=1S/C18H19NO2/c1-19-10-11-4-2-3-5-12(11)17-13-7-9-16(20)18(21)14(13)6-8-15(17)19/h2-5,7,9,15,17,20-21H,6,8,10H2,1H3/t15-,17-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



University of North Carolina

Curated by ChEMBL


Assay Description
Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...


J Med Chem 39: 285-96 (1996)


Article DOI: 10.1021/jm9502100
BindingDB Entry DOI: 10.7270/Q2NZ86Q3
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50049046
PNG
((6aR,12bS)-6-Allyl-5,6,6a,7,8,12b-hexahydro-benzo[...)
Show SMILES Oc1cc2CC[C@@H]3[C@H](c4ccccc4CN3CC=C)c2cc1O
Show InChI InChI=1S/C20H21NO2/c1-2-9-21-12-14-5-3-4-6-15(14)20-16-11-19(23)18(22)10-13(16)7-8-17(20)21/h2-6,10-11,17,20,22-23H,1,7-9,12H2/t17-,20-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



University of North Carolina

Curated by ChEMBL


Assay Description
Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...


J Med Chem 39: 285-96 (1996)


Article DOI: 10.1021/jm9502100
BindingDB Entry DOI: 10.7270/Q2NZ86Q3
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50010685
PNG
((+/-)-trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahyd...)
Show SMILES Oc1cc2CC[C@H]3NCc4ccccc4[C@H]3c2cc1O
Show InChI InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17+/m1/s1
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n/an/an/an/a 1.00E+4n/an/an/an/a



University of North Carolina

Curated by ChEMBL


Assay Description
Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...


J Med Chem 39: 285-96 (1996)


Article DOI: 10.1021/jm9502100
BindingDB Entry DOI: 10.7270/Q2NZ86Q3
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50019396
PNG
(4-(2-Dipropylamino-ethyl)-benzene-1,2-diol | 4-(2-...)
Show SMILES CCCN(CCC)CCc1ccc(O)c(O)c1
Show InChI InChI=1S/C14H23NO2/c1-3-8-15(9-4-2)10-7-12-5-6-13(16)14(17)11-12/h5-6,11,16-17H,3-4,7-10H2,1-2H3
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n/an/an/an/a 1.25E+4n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes


J Med Chem 30: 1166-76 (1987)


Article DOI: 10.1021/jm00390a009
BindingDB Entry DOI: 10.7270/Q2028QJ6
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50019393
PNG
(4-(2-Dipropylamino-ethyl)-7-hydroxy-1,3-dihydro-in...)
Show SMILES CCCN(CCC)CCc1ccc(O)c2NC(=O)Cc12
Show InChI InChI=1S/C16H24N2O2/c1-3-8-18(9-4-2)10-7-12-5-6-14(19)16-13(12)11-15(20)17-16/h5-6,19H,3-4,7-11H2,1-2H3,(H,17,20)
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n/an/an/an/a 2.00E+4n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Dopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes


J Med Chem 30: 1166-76 (1987)


Article DOI: 10.1021/jm00390a009
BindingDB Entry DOI: 10.7270/Q2028QJ6
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50378584
PNG
(STEPHOLIDINE)
Show SMILES COc1cc2CCN3Cc4c(C[C@H]3c2cc1O)ccc(O)c4OC
Show InChI InChI=1S/C19H21NO4/c1-23-18-8-12-5-6-20-10-14-11(3-4-16(21)19(14)24-2)7-15(20)13(12)9-17(18)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3/t15-/m0/s1
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n/an/an/an/a 4.11E+4n/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Agonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activity


Bioorg Med Chem 20: 4862-71 (2012)


Article DOI: 10.1016/j.bmc.2012.05.057
BindingDB Entry DOI: 10.7270/Q28P61K9
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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0.0800n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390


J Med Chem 43: 2079-81 (2000)


Article DOI: 10.1021/jm9911478
BindingDB Entry DOI: 10.7270/Q2C53MJH
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50145616
PNG
(CHEMBL3763331)
Show SMILES Cl.Fc1ccc(cc1)C(N1CCN(CCCNC(=O)c2ccncc2)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C26H28F2N4O.ClH/c27-23-6-2-20(3-7-23)25(21-4-8-24(28)9-5-21)32-18-16-31(17-19-32)15-1-12-30-26(33)22-10-13-29-14-11-22;/h2-11,13-14,25H,1,12,15-19H2,(H,30,33);1H
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0.0983n/an/an/an/an/an/an/an/a



Dipartimento di Farmacia Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis


Eur J Med Chem 110: 133-50 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.021
BindingDB Entry DOI: 10.7270/Q24X59N9
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM86266
PNG
(MCL-204)
Show SMILES Cc1cccc(c1)C1CN(CC=C)CCc2c(Br)c(O)c(O)cc12
Show InChI InChI=1S/C20H22BrNO2/c1-3-8-22-9-7-15-16(11-18(23)20(24)19(15)21)17(12-22)14-6-4-5-13(2)10-14/h3-6,10-11,17,23-24H,1,7-9,12H2,2H3
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0.110n/an/an/an/an/an/an/an/a



Harvard University

Curated by PDSP Ki Database




Eur J Pharmacol 474: 137-40 (2003)


BindingDB Entry DOI: 10.7270/Q2DN43MQ
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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0.120n/an/an/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudateputamen tissue from rat brain


Bioorg Med Chem Lett 10: 1113-5 (2000)


Article DOI: 10.1016/s0960-894x(00)00185-2
BindingDB Entry DOI: 10.7270/Q21N81NF
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM86180
PNG
(CAS_87075-17-0 | NSC_5018 | SCH 23390 | SCH23390 |...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)c1ccccc1
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3
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0.120n/an/an/an/an/an/an/an/a



Harvard University

Curated by PDSP Ki Database




Eur J Pharmacol 474: 137-40 (2003)


BindingDB Entry DOI: 10.7270/Q2DN43MQ
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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0.140n/an/an/an/an/an/an/an/a



Université Catholique de Louvain

Curated by PDSP Ki Database




Life Sci 37: 1971-83 (1985)


BindingDB Entry DOI: 10.7270/Q2HX1B5B
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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0.140n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1


J Med Chem 30: 1433-54 (1987)


Article DOI: 10.1021/jm00391a028
BindingDB Entry DOI: 10.7270/Q2D50NJ3
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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0.140n/an/an/an/an/an/an/an/a



Karolinska Institutet

Curated by PDSP Ki Database




Psychopharmacology (Berl) 113: 149-56 (1993)


Article DOI: 10.1016/j.bioorg.2014.11.005
BindingDB Entry DOI: 10.7270/Q29P3047
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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0.140n/an/an/an/an/an/an/an/a



Novo Nordisk

Curated by PDSP Ki Database




Eur J Pharmacol 219: 45-52 (1992)


BindingDB Entry DOI: 10.7270/Q2H70D9P
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM81778
PNG
(CAS_132421 | NNC-756 | NSC_132421)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)c1cccc2CCOc12
Show InChI InChI=1S/C19H20ClNO2/c1-21-7-5-13-9-17(20)18(22)10-15(13)16(11-21)14-4-2-3-12-6-8-23-19(12)14/h2-4,9-10,16,22H,5-8,11H2,1H3
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0.170n/an/an/an/an/an/an/an/a



Novo Nordisk

Curated by PDSP Ki Database




Eur J Pharmacol 219: 45-52 (1992)


BindingDB Entry DOI: 10.7270/Q2H70D9P
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM81778
PNG
(CAS_132421 | NNC-756 | NSC_132421)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)c1cccc2CCOc12
Show InChI InChI=1S/C19H20ClNO2/c1-21-7-5-13-9-17(20)18(22)10-15(13)16(11-21)14-4-2-3-12-6-8-23-19(12)14/h2-4,9-10,16,22H,5-8,11H2,1H3
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0.170n/an/an/an/an/an/an/an/a



Karolinska Institutet

Curated by PDSP Ki Database




Psychopharmacology (Berl) 113: 149-56 (1993)


Article DOI: 10.1016/j.bioorg.2014.11.005
BindingDB Entry DOI: 10.7270/Q29P3047
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50010709
PNG
(5-Benzofuran-7-yl-8-chloro-3-methyl-2,3,4,5-tetrah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1cccc2ccoc12
Show InChI InChI=1S/C19H18ClNO2/c1-21-7-5-13-9-17(20)18(22)10-15(13)16(11-21)14-4-2-3-12-6-8-23-19(12)14/h2-4,6,8-10,16,22H,5,7,11H2,1H3/t16-/m1/s1
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0.180n/an/an/an/an/an/an/an/a



Novo Nordisk

Curated by PDSP Ki Database




Eur J Pharmacol 219: 45-52 (1992)


BindingDB Entry DOI: 10.7270/Q2H70D9P
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM86275
PNG
(MCL-203)
Show SMILES CN1CCc2c(Br)c(O)c(O)cc2[C@@H](C1)c1cccc(C)c1
Show InChI InChI=1S/C18H20BrNO2/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3/t15-/m0/s1
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0.190n/an/an/an/an/an/an/an/a



Harvard University

Curated by PDSP Ki Database




Eur J Pharmacol 474: 137-40 (2003)


BindingDB Entry DOI: 10.7270/Q2DN43MQ
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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0.200n/an/an/an/an/an/an/an/a



Boehringer Ingelheim Italia

Curated by PDSP Ki Database




Naunyn Schmiedebergs Arch Pharmacol 352: 276-82 (1995)


BindingDB Entry DOI: 10.7270/Q2Q52N48
More data for this
Ligand-Target Pair
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