BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 3812 hits Enz. Inhib. hit(s) with Target = 'Dual-specificity tyrosine-phosphorylation regulated kinase 1A'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293423
PNG
(US10106527, Compound 461 | US10106527, Compound 9 ...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCNCC3)cc2c1
Show InChI InChI=1S/C23H23N7O/c1-29-15-20(14-27-29)16-2-3-18-13-26-21(11-19(18)10-16)28-23(31)17-4-5-25-22(12-17)30-8-6-24-7-9-30/h2-5,10-15,24H,6-9H2,1H3,(H,26,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.400n/an/an/a25



Samumed, LLC

US Patent


Assay Description
Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 μ...


US Patent US10106527 (2018)


BindingDB Entry DOI: 10.7270/Q2PN97Q3
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385213
PNG
(US10287267, Compound 452 | US10508099, Compound 45...)
Show SMILES Cn1cc(nn1)-c1ccc2cnc(NC(=O)C3CCNCC3)cc2c1
Show InChI InChI=1S/C18H20N6O/c1-24-11-16(22-23-24)13-2-3-14-10-20-17(9-15(14)8-13)21-18(25)12-4-6-19-7-5-12/h2-3,8-12,19H,4-7H2,1H3,(H,20,21,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.400n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...


US Patent US10508099 (2019)


BindingDB Entry DOI: 10.7270/Q2DJ5J0C
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293423
PNG
(US10106527, Compound 461 | US10106527, Compound 9 ...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCNCC3)cc2c1
Show InChI InChI=1S/C23H23N7O/c1-29-15-20(14-27-29)16-2-3-18-13-26-21(11-19(18)10-16)28-23(31)17-4-5-25-22(12-17)30-8-6-24-7-9-30/h2-5,10-15,24H,6-9H2,1H3,(H,26,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.400n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)


BindingDB Entry DOI: 10.7270/Q2862JRD
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385213
PNG
(US10287267, Compound 452 | US10508099, Compound 45...)
Show SMILES Cn1cc(nn1)-c1ccc2cnc(NC(=O)C3CCNCC3)cc2c1
Show InChI InChI=1S/C18H20N6O/c1-24-11-16(22-23-24)13-2-3-14-10-20-17(9-15(14)8-13)21-18(25)12-4-6-19-7-5-12/h2-3,8-12,19H,4-7H2,1H3,(H,20,21,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.400n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions. This is a non-radioactive...


US Patent US10556885 (2020)


BindingDB Entry DOI: 10.7270/Q2ZW1P9Z
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293423
PNG
(US10106527, Compound 461 | US10106527, Compound 9 ...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCNCC3)cc2c1
Show InChI InChI=1S/C23H23N7O/c1-29-15-20(14-27-29)16-2-3-18-13-26-21(11-19(18)10-16)28-23(31)17-4-5-25-22(12-17)30-8-6-24-7-9-30/h2-5,10-15,24H,6-9H2,1H3,(H,26,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.400n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...


US Patent US10544128 (2020)


BindingDB Entry DOI: 10.7270/Q2H134DS
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385213
PNG
(US10287267, Compound 452 | US10508099, Compound 45...)
Show SMILES Cn1cc(nn1)-c1ccc2cnc(NC(=O)C3CCNCC3)cc2c1
Show InChI InChI=1S/C18H20N6O/c1-24-11-16(22-23-24)13-2-3-14-10-20-17(9-15(14)8-13)21-18(25)12-4-6-19-7-5-12/h2-3,8-12,19H,4-7H2,1H3,(H,20,21,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.400n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...


US Patent US10287267 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W3C
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293564
PNG
(US10106527, Compound 275 | US10544128, Compound 27...)
Show SMILES CC(C)N1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncn1C
Show InChI InChI=1S/C26H29N7O/c1-18(2)32-8-10-33(11-9-32)25-14-20(6-7-28-25)26(34)30-24-13-22-12-19(4-5-21(22)15-29-24)23-16-27-17-31(23)3/h4-7,12-18H,8-11H2,1-3H3,(H,29,30,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.600n/an/an/a25



Samumed, LLC

US Patent


Assay Description
Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 μ...


US Patent US10106527 (2018)


BindingDB Entry DOI: 10.7270/Q2PN97Q3
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385194
PNG
(US10287267, Compound 358 | US10508099, Compound 35...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCN(CCO)CC3)cc2c1
Show InChI InChI=1S/C21H25N5O2/c1-25-14-19(13-23-25)16-2-3-17-12-22-20(11-18(17)10-16)24-21(28)15-4-6-26(7-5-15)8-9-27/h2-3,10-15,27H,4-9H2,1H3,(H,22,24,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.600n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...


US Patent US10508099 (2019)


BindingDB Entry DOI: 10.7270/Q2DJ5J0C
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385194
PNG
(US10287267, Compound 358 | US10508099, Compound 35...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCN(CCO)CC3)cc2c1
Show InChI InChI=1S/C21H25N5O2/c1-25-14-19(13-23-25)16-2-3-17-12-22-20(11-18(17)10-16)24-21(28)15-4-6-26(7-5-15)8-9-27/h2-3,10-15,27H,4-9H2,1H3,(H,22,24,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.600n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...


US Patent US10287267 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W3C
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385194
PNG
(US10287267, Compound 358 | US10508099, Compound 35...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCN(CCO)CC3)cc2c1
Show InChI InChI=1S/C21H25N5O2/c1-25-14-19(13-23-25)16-2-3-17-12-22-20(11-18(17)10-16)24-21(28)15-4-6-26(7-5-15)8-9-27/h2-3,10-15,27H,4-9H2,1H3,(H,22,24,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.600n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions. This is a non-radioactive...


US Patent US10556885 (2020)


BindingDB Entry DOI: 10.7270/Q2ZW1P9Z
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293564
PNG
(US10106527, Compound 275 | US10544128, Compound 27...)
Show SMILES CC(C)N1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncn1C
Show InChI InChI=1S/C26H29N7O/c1-18(2)32-8-10-33(11-9-32)25-14-20(6-7-28-25)26(34)30-24-13-22-12-19(4-5-21(22)15-29-24)23-16-27-17-31(23)3/h4-7,12-18H,8-11H2,1-3H3,(H,29,30,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.600n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)


BindingDB Entry DOI: 10.7270/Q2862JRD
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293564
PNG
(US10106527, Compound 275 | US10544128, Compound 27...)
Show SMILES CC(C)N1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncn1C
Show InChI InChI=1S/C26H29N7O/c1-18(2)32-8-10-33(11-9-32)25-14-20(6-7-28-25)26(34)30-24-13-22-12-19(4-5-21(22)15-29-24)23-16-27-17-31(23)3/h4-7,12-18H,8-11H2,1-3H3,(H,29,30,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.600n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...


US Patent US10544128 (2020)


BindingDB Entry DOI: 10.7270/Q2H134DS
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293479
PNG
(US10106527, Compound 93 | US10544128, Compound 93 ...)
Show SMILES CN1CCC2(CN(C2)c2cc(ccn2)C(=O)Nc2cc3cc(ccc3cn2)-c2cnn(C)c2)CC1
Show InChI InChI=1S/C27H29N7O/c1-32-9-6-27(7-10-32)17-34(18-27)25-13-20(5-8-28-25)26(35)31-24-12-22-11-19(3-4-21(22)14-29-24)23-15-30-33(2)16-23/h3-5,8,11-16H,6-7,9-10,17-18H2,1-2H3,(H,29,31,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.700n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...


US Patent US10544128 (2020)


BindingDB Entry DOI: 10.7270/Q2H134DS
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293619
PNG
(US10106527, Compound 391 | US10544128, Compound 39...)
Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1nncs1
Show InChI InChI=1S/C22H21N7OS/c1-28-6-8-29(9-7-28)20-12-15(4-5-23-20)21(30)26-19-11-18-10-16(22-27-25-14-31-22)2-3-17(18)13-24-19/h2-5,10-14H,6-9H2,1H3,(H,24,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.700n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...


US Patent US10544128 (2020)


BindingDB Entry DOI: 10.7270/Q2H134DS
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293479
PNG
(US10106527, Compound 93 | US10544128, Compound 93 ...)
Show SMILES CN1CCC2(CN(C2)c2cc(ccn2)C(=O)Nc2cc3cc(ccc3cn2)-c2cnn(C)c2)CC1
Show InChI InChI=1S/C27H29N7O/c1-32-9-6-27(7-10-32)17-34(18-27)25-13-20(5-8-28-25)26(35)31-24-12-22-11-19(3-4-21(22)14-29-24)23-15-30-33(2)16-23/h3-5,8,11-16H,6-7,9-10,17-18H2,1-2H3,(H,29,31,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.700n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)


BindingDB Entry DOI: 10.7270/Q2862JRD
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293619
PNG
(US10106527, Compound 391 | US10544128, Compound 39...)
Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1nncs1
Show InChI InChI=1S/C22H21N7OS/c1-28-6-8-29(9-7-28)20-12-15(4-5-23-20)21(30)26-19-11-18-10-16(22-27-25-14-31-22)2-3-17(18)13-24-19/h2-5,10-14H,6-9H2,1H3,(H,24,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.700n/an/an/a25



Samumed, LLC

US Patent


Assay Description
Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 μ...


US Patent US10106527 (2018)


BindingDB Entry DOI: 10.7270/Q2PN97Q3
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293479
PNG
(US10106527, Compound 93 | US10544128, Compound 93 ...)
Show SMILES CN1CCC2(CN(C2)c2cc(ccn2)C(=O)Nc2cc3cc(ccc3cn2)-c2cnn(C)c2)CC1
Show InChI InChI=1S/C27H29N7O/c1-32-9-6-27(7-10-32)17-34(18-27)25-13-20(5-8-28-25)26(35)31-24-12-22-11-19(3-4-21(22)14-29-24)23-15-30-33(2)16-23/h3-5,8,11-16H,6-7,9-10,17-18H2,1-2H3,(H,29,31,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.700n/an/an/a25



Samumed, LLC

US Patent


Assay Description
Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 μ...


US Patent US10106527 (2018)


BindingDB Entry DOI: 10.7270/Q2PN97Q3
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293619
PNG
(US10106527, Compound 391 | US10544128, Compound 39...)
Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1nncs1
Show InChI InChI=1S/C22H21N7OS/c1-28-6-8-29(9-7-28)20-12-15(4-5-23-20)21(30)26-19-11-18-10-16(22-27-25-14-31-22)2-3-17(18)13-24-19/h2-5,10-14H,6-9H2,1H3,(H,24,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.700n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)


BindingDB Entry DOI: 10.7270/Q2862JRD
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293616
PNG
(US10106527, Compound 388 | US10544128, Compound 38...)
Show SMILES CN1CCN(CC1)c1ccc(cn1)C(=O)Nc1cc2cc(ccc2cn1)-c1nncs1
Show InChI InChI=1S/C22H21N7OS/c1-28-6-8-29(9-7-28)20-5-4-17(13-24-20)21(30)26-19-11-18-10-15(22-27-25-14-31-22)2-3-16(18)12-23-19/h2-5,10-14H,6-9H2,1H3,(H,23,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.800n/an/an/a25



Samumed, LLC

US Patent


Assay Description
Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 μ...


US Patent US10106527 (2018)


BindingDB Entry DOI: 10.7270/Q2PN97Q3
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293569
PNG
(US10106527, Compound 286 | US10544128, Compound 28...)
Show SMILES CN1Cc2ccc(cc2C1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncn1C
Show InChI InChI=1S/C23H21N5O/c1-27-12-18-6-4-16(8-20(18)13-27)23(29)26-22-9-19-7-15(3-5-17(19)10-25-22)21-11-24-14-28(21)2/h3-11,14H,12-13H2,1-2H3,(H,25,26,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.800n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)


BindingDB Entry DOI: 10.7270/Q2862JRD
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385228
PNG
(US10287267, Compound 528 | US10508099, Compound 52...)
Show SMILES CO[C@H]1CC[C@@H](CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncn1C
Show InChI InChI=1S/C21H24N4O2/c1-25-13-22-12-19(25)15-3-4-16-11-23-20(10-17(16)9-15)24-21(26)14-5-7-18(27-2)8-6-14/h3-4,9-14,18H,5-8H2,1-2H3,(H,23,24,26)/t14-,18-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.800n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...


US Patent US10508099 (2019)


BindingDB Entry DOI: 10.7270/Q2DJ5J0C
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385228
PNG
(US10287267, Compound 528 | US10508099, Compound 52...)
Show SMILES CO[C@H]1CC[C@@H](CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncn1C
Show InChI InChI=1S/C21H24N4O2/c1-25-13-22-12-19(25)15-3-4-16-11-23-20(10-17(16)9-15)24-21(26)14-5-7-18(27-2)8-6-14/h3-4,9-14,18H,5-8H2,1-2H3,(H,23,24,26)/t14-,18-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.800n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...


US Patent US10287267 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W3C
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293415
PNG
(US10106527, Compound 1 | US10106527, Compound 145 ...)
Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cn[nH]c1
Show InChI InChI=1S/C23H23N7O/c1-29-6-8-30(9-7-29)22-12-17(4-5-24-22)23(31)28-21-11-19-10-16(20-14-26-27-15-20)2-3-18(19)13-25-21/h2-5,10-15H,6-9H2,1H3,(H,26,27)(H,25,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.800n/an/an/a25



Samumed, LLC

US Patent


Assay Description
Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 μ...


US Patent US10106527 (2018)


BindingDB Entry DOI: 10.7270/Q2PN97Q3
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293415
PNG
(US10106527, Compound 1 | US10106527, Compound 145 ...)
Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cn[nH]c1
Show InChI InChI=1S/C23H23N7O/c1-29-6-8-30(9-7-29)22-12-17(4-5-24-22)23(31)28-21-11-19-10-16(20-14-26-27-15-20)2-3-18(19)13-25-21/h2-5,10-15H,6-9H2,1H3,(H,26,27)(H,25,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.800n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...


US Patent US10544128 (2020)


BindingDB Entry DOI: 10.7270/Q2H134DS
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293566
PNG
(US10106527, Compound 277 | US10544128, Compound 27...)
Show SMILES Cn1cncc1-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CC4(C3)CCNCC4)cc2c1
Show InChI InChI=1S/C26H27N7O/c1-32-17-28-14-22(32)18-2-3-20-13-30-23(11-21(20)10-18)31-25(34)19-4-7-29-24(12-19)33-15-26(16-33)5-8-27-9-6-26/h2-4,7,10-14,17,27H,5-6,8-9,15-16H2,1H3,(H,30,31,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.800n/an/an/a25



Samumed, LLC

US Patent


Assay Description
Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 μ...


US Patent US10106527 (2018)


BindingDB Entry DOI: 10.7270/Q2PN97Q3
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293569
PNG
(US10106527, Compound 286 | US10544128, Compound 28...)
Show SMILES CN1Cc2ccc(cc2C1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncn1C
Show InChI InChI=1S/C23H21N5O/c1-27-12-18-6-4-16(8-20(18)13-27)23(29)26-22-9-19-7-15(3-5-17(19)10-25-22)21-11-24-14-28(21)2/h3-11,14H,12-13H2,1-2H3,(H,25,26,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.800n/an/an/a25



Samumed, LLC

US Patent


Assay Description
Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 μ...


US Patent US10106527 (2018)


BindingDB Entry DOI: 10.7270/Q2PN97Q3
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385228
PNG
(US10287267, Compound 528 | US10508099, Compound 52...)
Show SMILES CO[C@H]1CC[C@@H](CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncn1C
Show InChI InChI=1S/C21H24N4O2/c1-25-13-22-12-19(25)15-3-4-16-11-23-20(10-17(16)9-15)24-21(26)14-5-7-18(27-2)8-6-14/h3-4,9-14,18H,5-8H2,1-2H3,(H,23,24,26)/t14-,18-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.800n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions. This is a non-radioactive...


US Patent US10556885 (2020)


BindingDB Entry DOI: 10.7270/Q2ZW1P9Z
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293415
PNG
(US10106527, Compound 1 | US10106527, Compound 145 ...)
Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cn[nH]c1
Show InChI InChI=1S/C23H23N7O/c1-29-6-8-30(9-7-29)22-12-17(4-5-24-22)23(31)28-21-11-19-10-16(20-14-26-27-15-20)2-3-18(19)13-25-21/h2-5,10-15H,6-9H2,1H3,(H,26,27)(H,25,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.800n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)


BindingDB Entry DOI: 10.7270/Q2862JRD
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293566
PNG
(US10106527, Compound 277 | US10544128, Compound 27...)
Show SMILES Cn1cncc1-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CC4(C3)CCNCC4)cc2c1
Show InChI InChI=1S/C26H27N7O/c1-32-17-28-14-22(32)18-2-3-20-13-30-23(11-21(20)10-18)31-25(34)19-4-7-29-24(12-19)33-15-26(16-33)5-8-27-9-6-26/h2-4,7,10-14,17,27H,5-6,8-9,15-16H2,1H3,(H,30,31,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.800n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...


US Patent US10544128 (2020)


BindingDB Entry DOI: 10.7270/Q2H134DS
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293569
PNG
(US10106527, Compound 286 | US10544128, Compound 28...)
Show SMILES CN1Cc2ccc(cc2C1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncn1C
Show InChI InChI=1S/C23H21N5O/c1-27-12-18-6-4-16(8-20(18)13-27)23(29)26-22-9-19-7-15(3-5-17(19)10-25-22)21-11-24-14-28(21)2/h3-11,14H,12-13H2,1-2H3,(H,25,26,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.800n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...


US Patent US10544128 (2020)


BindingDB Entry DOI: 10.7270/Q2H134DS
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293616
PNG
(US10106527, Compound 388 | US10544128, Compound 38...)
Show SMILES CN1CCN(CC1)c1ccc(cn1)C(=O)Nc1cc2cc(ccc2cn1)-c1nncs1
Show InChI InChI=1S/C22H21N7OS/c1-28-6-8-29(9-7-28)20-5-4-17(13-24-20)21(30)26-19-11-18-10-15(22-27-25-14-31-22)2-3-16(18)12-23-19/h2-5,10-14H,6-9H2,1H3,(H,23,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.800n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)


BindingDB Entry DOI: 10.7270/Q2862JRD
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293616
PNG
(US10106527, Compound 388 | US10544128, Compound 38...)
Show SMILES CN1CCN(CC1)c1ccc(cn1)C(=O)Nc1cc2cc(ccc2cn1)-c1nncs1
Show InChI InChI=1S/C22H21N7OS/c1-28-6-8-29(9-7-28)20-5-4-17(13-24-20)21(30)26-19-11-18-10-15(22-27-25-14-31-22)2-3-16(18)12-23-19/h2-5,10-14H,6-9H2,1H3,(H,23,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.800n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...


US Patent US10544128 (2020)


BindingDB Entry DOI: 10.7270/Q2H134DS
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293566
PNG
(US10106527, Compound 277 | US10544128, Compound 27...)
Show SMILES Cn1cncc1-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CC4(C3)CCNCC4)cc2c1
Show InChI InChI=1S/C26H27N7O/c1-32-17-28-14-22(32)18-2-3-20-13-30-23(11-21(20)10-18)31-25(34)19-4-7-29-24(12-19)33-15-26(16-33)5-8-27-9-6-26/h2-4,7,10-14,17,27H,5-6,8-9,15-16H2,1H3,(H,30,31,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.800n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)


BindingDB Entry DOI: 10.7270/Q2862JRD
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293613
PNG
(US10106527, Compound 385 | US10544128, Compound 38...)
Show SMILES CN1CCC(CC1)Oc1ccc(cc1)C(=O)Nc1cc2cc(ccc2cn1)-c1nncs1
Show InChI InChI=1S/C24H23N5O2S/c1-29-10-8-21(9-11-29)31-20-6-4-16(5-7-20)23(30)27-22-13-19-12-17(24-28-26-15-32-24)2-3-18(19)14-25-22/h2-7,12-15,21H,8-11H2,1H3,(H,25,27,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...


US Patent US10544128 (2020)


BindingDB Entry DOI: 10.7270/Q2H134DS
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293577
PNG
(US10106527, Compound 301 | US10544128, Compound 30...)
Show SMILES CN1CCC(CC1)Oc1cccc(c1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnco1
Show InChI InChI=1S/C25H24N4O3/c1-29-9-7-21(8-10-29)32-22-4-2-3-18(12-22)25(30)28-24-13-20-11-17(23-15-26-16-31-23)5-6-19(20)14-27-24/h2-6,11-16,21H,7-10H2,1H3,(H,27,28,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...


US Patent US10544128 (2020)


BindingDB Entry DOI: 10.7270/Q2H134DS
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385246
PNG
(US10287267, Compound 741 | US10508099, Compound 74...)
Show SMILES O=C(CN1CCCC1)N1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncs1
Show InChI InChI=1S/C24H27N5O2S/c30-23(15-28-7-1-2-8-28)29-9-5-17(6-10-29)24(31)27-22-12-20-11-18(21-14-25-16-32-21)3-4-19(20)13-26-22/h3-4,11-14,16-17H,1-2,5-10,15H2,(H,26,27,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions. This is a non-radioactive...


US Patent US10556885 (2020)


BindingDB Entry DOI: 10.7270/Q2ZW1P9Z
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385240
PNG
(US10287267, Compound 707 | US10508099, Compound 70...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncs1
Show InChI InChI=1S/C21H24N4OS/c1-25(2)18-7-5-14(6-8-18)21(26)24-20-10-17-9-15(19-12-22-13-27-19)3-4-16(17)11-23-20/h3-4,9-14,18H,5-8H2,1-2H3,(H,23,24,26)/t14-,18-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions. This is a non-radioactive...


US Patent US10556885 (2020)


BindingDB Entry DOI: 10.7270/Q2ZW1P9Z
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385229
PNG
(US10287267, Compound 531 | US10508099, Compound 53...)
Show SMILES Cn1cncc1-c1ccc2cnc(NC(=O)[C@H]3CC[C@H](CO)CC3)cc2c1
Show InChI InChI=1S/C21H24N4O2/c1-25-13-22-11-19(25)16-6-7-17-10-23-20(9-18(17)8-16)24-21(27)15-4-2-14(12-26)3-5-15/h6-11,13-15,26H,2-5,12H2,1H3,(H,23,24,27)/t14-,15-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions. This is a non-radioactive...


US Patent US10556885 (2020)


BindingDB Entry DOI: 10.7270/Q2ZW1P9Z
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385082
PNG
(US10287267, Compound 304 | US10287267, Compound 82...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCN(CCC(F)(F)F)CC3)cc2c1
Show InChI InChI=1S/C22H24F3N5O/c1-29-14-19(13-27-29)16-2-3-17-12-26-20(11-18(17)10-16)28-21(31)15-4-7-30(8-5-15)9-6-22(23,24)25/h2-3,10-15H,4-9H2,1H3,(H,26,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions. This is a non-radioactive...


US Patent US10556885 (2020)


BindingDB Entry DOI: 10.7270/Q2ZW1P9Z
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293444
PNG
(US10106527, Compound 37 | US10544128, Compound 37 ...)
Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncn1C
Show InChI InChI=1S/C24H25N7O/c1-29-7-9-31(10-8-29)23-13-18(5-6-26-23)24(32)28-22-12-20-11-17(3-4-19(20)14-27-22)21-15-25-16-30(21)2/h3-6,11-16H,7-10H2,1-2H3,(H,27,28,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...


US Patent US10544128 (2020)


BindingDB Entry DOI: 10.7270/Q2H134DS
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293428
PNG
(US10106527, Compound 14 | US10544128, Compound 14 ...)
Show SMILES CN1CCN(CC1)c1ccc(cn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C24H25N7O/c1-29-7-9-31(10-8-29)23-6-5-19(14-26-23)24(32)28-22-12-20-11-17(3-4-18(20)13-25-22)21-15-27-30(2)16-21/h3-6,11-16H,7-10H2,1-2H3,(H,25,28,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...


US Patent US10544128 (2020)


BindingDB Entry DOI: 10.7270/Q2H134DS
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293422
PNG
(US10106527, Compound 8 | US10544128, Compound 8 | ...)
Show SMILES CN1CCC(CC1)Oc1ccc(cc1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C26H27N5O2/c1-30-11-9-24(10-12-30)33-23-7-5-18(6-8-23)26(32)29-25-14-21-13-19(3-4-20(21)15-27-25)22-16-28-31(2)17-22/h3-8,13-17,24H,9-12H2,1-2H3,(H,27,29,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...


US Patent US10544128 (2020)


BindingDB Entry DOI: 10.7270/Q2H134DS
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293417
PNG
(US10106527, Compound 3 | US10544128, Compound 3 | ...)
Show SMILES CN1CCN(CC1)c1cccc(c1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26N6O/c1-29-8-10-31(11-9-29)23-5-3-4-19(13-23)25(32)28-24-14-21-12-18(6-7-20(21)15-26-24)22-16-27-30(2)17-22/h3-7,12-17H,8-11H2,1-2H3,(H,26,28,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...


US Patent US10544128 (2020)


BindingDB Entry DOI: 10.7270/Q2H134DS
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385246
PNG
(US10287267, Compound 741 | US10508099, Compound 74...)
Show SMILES O=C(CN1CCCC1)N1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncs1
Show InChI InChI=1S/C24H27N5O2S/c30-23(15-28-7-1-2-8-28)29-9-5-17(6-10-29)24(31)27-22-12-20-11-18(21-14-25-16-32-21)3-4-19(20)13-26-22/h3-4,11-14,16-17H,1-2,5-10,15H2,(H,26,27,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...


US Patent US10508099 (2019)


BindingDB Entry DOI: 10.7270/Q2DJ5J0C
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385240
PNG
(US10287267, Compound 707 | US10508099, Compound 70...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncs1
Show InChI InChI=1S/C21H24N4OS/c1-25(2)18-7-5-14(6-8-18)21(26)24-20-10-17-9-15(19-12-22-13-27-19)3-4-16(17)11-23-20/h3-4,9-14,18H,5-8H2,1-2H3,(H,23,24,26)/t14-,18-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...


US Patent US10508099 (2019)


BindingDB Entry DOI: 10.7270/Q2DJ5J0C
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385229
PNG
(US10287267, Compound 531 | US10508099, Compound 53...)
Show SMILES Cn1cncc1-c1ccc2cnc(NC(=O)[C@H]3CC[C@H](CO)CC3)cc2c1
Show InChI InChI=1S/C21H24N4O2/c1-25-13-22-11-19(25)16-6-7-17-10-23-20(9-18(17)8-16)24-21(27)15-4-2-14(12-26)3-5-15/h6-11,13-15,26H,2-5,12H2,1H3,(H,23,24,27)/t14-,15-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...


US Patent US10508099 (2019)


BindingDB Entry DOI: 10.7270/Q2DJ5J0C
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385082
PNG
(US10287267, Compound 304 | US10287267, Compound 82...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCN(CCC(F)(F)F)CC3)cc2c1
Show InChI InChI=1S/C22H24F3N5O/c1-29-14-19(13-27-29)16-2-3-17-12-26-20(11-18(17)10-16)28-21(31)15-4-7-30(8-5-15)9-6-22(23,24)25/h2-3,10-15H,4-9H2,1H3,(H,26,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...


US Patent US10508099 (2019)


BindingDB Entry DOI: 10.7270/Q2DJ5J0C
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM385082
PNG
(US10287267, Compound 304 | US10287267, Compound 82...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCN(CCC(F)(F)F)CC3)cc2c1
Show InChI InChI=1S/C22H24F3N5O/c1-29-14-19(13-27-29)16-2-3-17-12-26-20(11-18(17)10-16)28-21(31)15-4-7-30(8-5-15)9-6-22(23,24)25/h2-3,10-15H,4-9H2,1H3,(H,26,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...


US Patent US10287267 (2019)


BindingDB Entry DOI: 10.7270/Q2MS3W3C
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293613
PNG
(US10106527, Compound 385 | US10544128, Compound 38...)
Show SMILES CN1CCC(CC1)Oc1ccc(cc1)C(=O)Nc1cc2cc(ccc2cn1)-c1nncs1
Show InChI InChI=1S/C24H23N5O2S/c1-29-10-8-21(9-11-29)31-20-6-4-16(5-7-20)23(30)27-22-13-19-12-17(24-28-26-15-32-24)2-3-18(19)14-25-22/h2-7,12-15,21H,8-11H2,1H3,(H,25,27,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)


BindingDB Entry DOI: 10.7270/Q2862JRD
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293577
PNG
(US10106527, Compound 301 | US10544128, Compound 30...)
Show SMILES CN1CCC(CC1)Oc1cccc(c1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnco1
Show InChI InChI=1S/C25H24N4O3/c1-29-9-7-21(8-10-29)32-22-4-2-3-18(12-22)25(30)28-24-13-20-11-17(23-15-26-16-31-23)5-6-19(20)14-27-24/h2-6,11-16,21H,7-10H2,1H3,(H,27,28,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)


BindingDB Entry DOI: 10.7270/Q2862JRD
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 3812 total )  |  Next  |  Last  >>
Jump to: