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Compile Data Set for Download or QSAR

Found 1366 hits Enz. Inhib. hit(s) with Target = 'Egl nine homolog 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286248
PNG
(CHEMBL4168030)
Show SMILES Cl.CCCCCc1cc(O)c(C(=O)NCC(O)=O)c2ncnn12
Show InChI InChI=1S/C14H18N4O4.ClH/c1-2-3-4-5-9-6-10(19)12(13-16-8-17-18(9)13)14(22)15-7-11(20)21;/h6,8,19H,2-5,7H2,1H3,(H,15,22)(H,20,21);1H
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n/an/an/an/a 4.20E+3n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286228
PNG
(CHEMBL4174643)
Show SMILES OC(=O)CNC(=O)c1c(O)cc(-c2cccc(Cl)c2)n2ncnc12
Show InChI InChI=1S/C15H11ClN4O4/c16-9-3-1-2-8(4-9)10-5-11(21)13(14-18-7-19-20(10)14)15(24)17-6-12(22)23/h1-5,7,21H,6H2,(H,17,24)(H,22,23)
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n/an/an/an/a 4.50E+3n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286072
PNG
(CHEMBL4164403)
Show SMILES Cl.OC(=O)CNC(=O)c1c(O)cc(C2CCCCC2)n2ncnc12
Show InChI InChI=1S/C15H18N4O4.ClH/c20-11-6-10(9-4-2-1-3-5-9)19-14(17-8-18-19)13(11)15(23)16-7-12(21)22;/h6,8-9,20H,1-5,7H2,(H,16,23)(H,21,22);1H
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n/an/an/an/a 4.70E+3n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286071
PNG
(CHEMBL4166742)
Show SMILES Cl.OC(=O)CNC(=O)c1c(O)cc(CCc2ccccc2)n2ncnc12
Show InChI InChI=1S/C17H16N4O4.ClH/c22-13-8-12(7-6-11-4-2-1-3-5-11)21-16(19-10-20-21)15(13)17(25)18-9-14(23)24;/h1-5,8,10,22H,6-7,9H2,(H,18,25)(H,23,24);1H
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n/an/an/an/a 5.70E+3n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286250
PNG
(CHEMBL4159751)
Show SMILES OC(=O)CNC(=O)c1c(O)cc(-c2cccc(Cl)c2)c2ncnn12
Show InChI InChI=1S/C15H11ClN4O4/c16-9-3-1-2-8(4-9)10-5-11(21)13(15(24)17-6-12(22)23)20-14(10)18-7-19-20/h1-5,7,21H,6H2,(H,17,24)(H,22,23)
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n/an/an/an/a 5.80E+3n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286068
PNG
(CHEMBL4171201)
Show SMILES Cl.OC(=O)CNC(=O)c1c(O)cc(CCc2ccc(F)cc2)n2ncnc12
Show InChI InChI=1S/C17H15FN4O4.ClH/c18-11-4-1-10(2-5-11)3-6-12-7-13(23)15(16-20-9-21-22(12)16)17(26)19-8-14(24)25;/h1-2,4-5,7,9,23H,3,6,8H2,(H,19,26)(H,24,25);1H
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n/an/an/an/a 5.80E+3n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286233
PNG
(CHEMBL4175892)
Show SMILES Cl.CCCCc1cc(O)c(C(=O)NCC(O)=O)c2ncnn12
Show InChI InChI=1S/C13H16N4O4.ClH/c1-2-3-4-8-5-9(18)11(12-15-7-16-17(8)12)13(21)14-6-10(19)20;/h5,7,18H,2-4,6H2,1H3,(H,14,21)(H,19,20);1H
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n/an/an/an/a 5.80E+3n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286251
PNG
(CHEMBL4167844)
Show SMILES Cl.CCCCCc1cn2ncnc2c(C(=O)NCC(O)=O)c1O
Show InChI InChI=1S/C14H18N4O4.ClH/c1-2-3-4-5-9-7-18-13(16-8-17-18)11(12(9)21)14(22)15-6-10(19)20;/h7-8,21H,2-6H2,1H3,(H,15,22)(H,19,20);1H
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n/an/an/an/a 9.30E+3n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286231
PNG
(CHEMBL4175056)
Show SMILES Cl.OC(=O)CNC(=O)c1c(O)cc(-c2ccccc2)n2ncnc12
Show InChI InChI=1S/C15H12N4O4.ClH/c20-11-6-10(9-4-2-1-3-5-9)19-14(17-8-18-19)13(11)15(23)16-7-12(21)22;/h1-6,8,20H,7H2,(H,16,23)(H,21,22);1H
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n/an/an/an/a 1.20E+4n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286263
PNG
(CHEMBL4167657)
Show SMILES Cl.OC(=O)CNC(=O)c1c(O)cc(CCc2ccccc2)c2ncnn12
Show InChI InChI=1S/C17H16N4O4.ClH/c22-13-8-12(7-6-11-4-2-1-3-5-11)16-19-10-20-21(16)15(13)17(25)18-9-14(23)24;/h1-5,8,10,22H,6-7,9H2,(H,18,25)(H,23,24);1H
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n/an/an/an/a 1.30E+4n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286230
PNG
(CHEMBL4171371)
Show SMILES Cl.CCCc1cc(O)c(C(=O)NCC(O)=O)c2ncnn12
Show InChI InChI=1S/C12H14N4O4.ClH/c1-2-3-7-4-8(17)10(11-14-6-15-16(7)11)12(20)13-5-9(18)19;/h4,6,17H,2-3,5H2,1H3,(H,13,20)(H,18,19);1H
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n/an/an/an/a 1.40E+4n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286232
PNG
(CHEMBL4173606)
Show SMILES Cl.OC(=O)CNC(=O)c1c(O)cc(-c2ccccc2)c2ncnn12
Show InChI InChI=1S/C15H12N4O4.ClH/c20-11-6-10(9-4-2-1-3-5-9)14-17-8-18-19(14)13(11)15(23)16-7-12(21)22;/h1-6,8,20H,7H2,(H,16,23)(H,21,22);1H
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n/an/an/an/a 1.40E+4n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286070
PNG
(CHEMBL4166512)
Show SMILES Cl.Cc1nc2c(C(=O)NCC(O)=O)c(O)cc(CCc3ccccc3)n2n1
Show InChI InChI=1S/C18H18N4O4.ClH/c1-11-20-17-16(18(26)19-10-15(24)25)14(23)9-13(22(17)21-11)8-7-12-5-3-2-4-6-12;/h2-6,9,23H,7-8,10H2,1H3,(H,19,26)(H,24,25);1H
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n/an/an/an/a 1.50E+4n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286224
PNG
(CHEMBL4162891)
Show SMILES Cl.OC(=O)CNC(=O)c1c(O)cc(C2CCCCC2)c2ncnn12
Show InChI InChI=1S/C15H18N4O4.ClH/c20-11-6-10(9-4-2-1-3-5-9)14-17-8-18-19(14)13(11)15(23)16-7-12(21)22;/h6,8-9,20H,1-5,7H2,(H,16,23)(H,21,22);1H
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n/an/an/an/a 1.70E+4n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM102348
PNG
(US8536181, A41 | US9278930, A41)
Show SMILES CC(C)(C)OC(=O)N1CCN(Cc2ccn(Cc3ccc(Cl)cc3)c(=O)c2O)CC1
Show InChI InChI=1S/C22H28ClN3O4/c1-22(2,3)30-21(29)25-12-10-24(11-13-25)15-17-8-9-26(20(28)19(17)27)14-16-4-6-18(23)7-5-16/h4-9,27H,10-15H2,1-3H3
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n/an/an/an/a 1.70E+4n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in HEK293 cells assessed as VEGF release by immunoassay


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286245
PNG
(CHEMBL4163070)
Show SMILES OC(=O)CNC(=O)c1nc(Cl)c2cc(Oc3ccccc3)ccc2c1O
Show InChI InChI=1S/C18H13ClN2O5/c19-17-13-8-11(26-10-4-2-1-3-5-10)6-7-12(13)16(24)15(21-17)18(25)20-9-14(22)23/h1-8,24H,9H2,(H,20,25)(H,22,23)
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n/an/an/an/a 1.90E+4n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286249
PNG
(CHEMBL4159929)
Show SMILES Cl.CCc1c(O)c(C(=O)NCC(O)=O)c2ncnn2c1CC
Show InChI InChI=1S/C13H16N4O4.ClH/c1-3-7-8(4-2)17-12(15-6-16-17)10(11(7)20)13(21)14-5-9(18)19;/h6,20H,3-5H2,1-2H3,(H,14,21)(H,18,19);1H
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n/an/an/an/a 2.10E+4n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286246
PNG
(CHEMBL4159695)
Show SMILES OC(=O)CNC(=O)c1c(O)ccc2ccnn12
Show InChI InChI=1S/C10H9N3O4/c14-7-2-1-6-3-4-12-13(6)9(7)10(17)11-5-8(15)16/h1-4,14H,5H2,(H,11,17)(H,15,16)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286229
PNG
(CHEMBL4167612)
Show SMILES OC(=O)CNC(=O)c1c(O)ccn2ccnc12
Show InChI InChI=1S/C10H9N3O4/c14-6-1-3-13-4-2-11-9(13)8(6)10(17)12-5-7(15)16/h1-4,14H,5H2,(H,12,17)(H,15,16)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286227
PNG
(CHEMBL4160770)
Show SMILES Cl.OC(=O)CNC(=O)c1c(O)ccc2ncnn12
Show InChI InChI=1S/C9H8N4O4.ClH/c14-5-1-2-6-11-4-12-13(6)8(5)9(17)10-3-7(15)16;/h1-2,4,14H,3H2,(H,10,17)(H,15,16);1H
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n/an/an/an/a>3.00E+4n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286247
PNG
(CHEMBL4164159)
Show SMILES Cl.OC(=O)CNC(=O)c1c(O)ccn2cnnc12
Show InChI InChI=1S/C9H8N4O4.ClH/c14-5-1-2-13-4-11-12-8(13)7(5)9(17)10-3-6(15)16;/h1-2,4,14H,3H2,(H,10,17)(H,15,16);1H
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n/an/an/an/a>3.00E+4n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50286069
PNG
(CHEMBL4174815)
Show SMILES Cl.OC(=O)CNC(=O)c1c(O)ccn2ncnc12
Show InChI InChI=1S/C9H8N4O4.ClH/c14-5-1-2-13-8(11-4-12-13)7(5)9(17)10-3-6(15)16;/h1-2,4,14H,3H2,(H,10,17)(H,15,16);1H
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n/an/an/an/a>3.00E+4n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50193145
PNG
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Show SMILES OC(=O)CNC(=O)c1nc(Cl)c2ccccc2c1O
Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17)
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n/an/an/an/a 7.90E+4n/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA


ACS Med Chem Lett 8: 1320-1325 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Egl nine homolog 1


(Homo sapiens (Human))
BDBM26106
PNG
(CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylg...)
Show SMILES OC(=O)CNC(=O)C(O)=O
Show InChI InChI=1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10)
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8.00E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human PHD2


Bioorg Med Chem 19: 3625-36 (2011)


Article DOI: 10.1016/j.bmc.2011.01.046
BindingDB Entry DOI: 10.7270/Q23X870S
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM47087
PNG
(US8921389, 149 | US9695170 149)
Show SMILES OC(=O)CCNC(=O)c1ncc2n(Cc3ccccc3)c(=O)c(cc2c1O)-c1ccc2nonc2c1
Show InChI InChI=1S/C25H19N5O6/c31-21(32)8-9-26-24(34)22-23(33)17-11-16(15-6-7-18-19(10-15)29-36-28-18)25(35)30(20(17)12-27-22)13-14-4-2-1-3-5-14/h1-7,10-12,33H,8-9,13H2,(H,26,34)(H,31,32)
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n/an/a 4.90E+3n/an/an/an/a7.4n/a



FibroGen Inc

US Patent


Assay Description
Ketoglutaric acid alpha -[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources,...


US Patent US8921389 (2014)


BindingDB Entry DOI: 10.7270/Q20G3HV0
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM47088
PNG
(US8921389, 194 | US9695170 194)
Show SMILES OC(=O)CCNC(=O)c1nc(-c2ccnnc2)c2n(Cc3ccccc3)c(=O)c(cc2c1O)-c1ccccc1
Show InChI InChI=1S/C29H23N5O5/c35-23(36)12-13-30-28(38)25-27(37)22-15-21(19-9-5-2-6-10-19)29(39)34(17-18-7-3-1-4-8-18)26(22)24(33-25)20-11-14-31-32-16-20/h1-11,14-16,37H,12-13,17H2,(H,30,38)(H,35,36)
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n/an/a 4.50E+3n/an/an/an/a7.4n/a



FibroGen Inc

US Patent


Assay Description
Ketoglutaric acid alpha -[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources,...


US Patent US8921389 (2014)


BindingDB Entry DOI: 10.7270/Q20G3HV0
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM47090
PNG
(US8921389, 203 | US9695170 203)
Show SMILES OC(=O)CCNC(=O)c1nc(-c2cccnn2)c2n(Cc3ccccc3)c(=O)c(cc2c1O)-c1ccccc1
Show InChI InChI=1S/C29H23N5O5/c35-23(36)13-15-30-28(38)25-27(37)21-16-20(19-10-5-2-6-11-19)29(39)34(17-18-8-3-1-4-9-18)26(21)24(32-25)22-12-7-14-31-33-22/h1-12,14,16,37H,13,15,17H2,(H,30,38)(H,35,36)
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n/an/a 2.00E+5n/an/an/an/a7.4n/a



FibroGen Inc

US Patent


Assay Description
Ketoglutaric acid alpha -[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources,...


US Patent US8921389 (2014)


BindingDB Entry DOI: 10.7270/Q20G3HV0
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93410
PNG
(PHD Inhibitor, 5)
Show SMILES CC(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C16H17N3O6/c1-8(20)17-6-9-3-4-11-10(5-9)14(23)13(16(25)19(11)2)15(24)18-7-12(21)22/h3-5,23H,6-7H2,1-2H3,(H,17,20)(H,18,24)(H,21,22)
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n/an/a 546n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93411
PNG
(PHD Inhibitor, 8{1})
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1/C25H26N4O7/c1-14(30)28-18(11-15-6-4-3-5-7-15)23(34)26-12-16-8-9-19-17(10-16)22(33)21(25(36)29(19)2)24(35)27-13-20(31)32/h3-10,18,33H,11-13H2,1-2H3,(H,26,34)(H,27,35)(H,28,30)(H,31,32)/t18-/s2
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n/an/a 482n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93412
PNG
(PHD Inhibitor, 8{2})
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1/C25H26N4O7/c1-14(30)28-18(11-15-6-4-3-5-7-15)23(34)26-12-16-8-9-19-17(10-16)22(33)21(25(36)29(19)2)24(35)27-13-20(31)32/h3-10,18,33H,11-13H2,1-2H3,(H,26,34)(H,27,35)(H,28,30)(H,31,32)/t18-/s2
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n/an/a 112n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93413
PNG
(PHD Inhibitor, 8{3})
Show SMILES CC(C)C[C@@H](NC(C)=O)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1/C22H28N4O7/c1-11(2)7-15(25-12(3)27)20(31)23-9-13-5-6-16-14(8-13)19(30)18(22(33)26(16)4)21(32)24-10-17(28)29/h5-6,8,11,15,30H,7,9-10H2,1-4H3,(H,23,31)(H,24,32)(H,25,27)(H,28,29)/t15-/s2
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n/an/a 521n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93414
PNG
(PHD Inhibitor, 8{4})
Show SMILES CC(=O)NCC(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C18H20N4O7/c1-9(23)19-7-13(24)20-6-10-3-4-12-11(5-10)16(27)15(18(29)22(12)2)17(28)21-8-14(25)26/h3-5,27H,6-8H2,1-2H3,(H,19,23)(H,20,24)(H,21,28)(H,25,26)
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n/an/a 293n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93415
PNG
(PHD Inhibitor, 8{5})
Show SMILES CC(=O)N[C@@H](CO)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1/C19H22N4O8/c1-9(25)22-12(8-24)17(29)20-6-10-3-4-13-11(5-10)16(28)15(19(31)23(13)2)18(30)21-7-14(26)27/h3-5,12,24,28H,6-8H2,1-2H3,(H,20,29)(H,21,30)(H,22,25)(H,26,27)/t12-/s2
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n/an/a 265n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93416
PNG
(PHD Inhibitor, 8{6})
Show SMILES CC(=O)N[C@@H](CC(O)=O)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1/C20H22N4O9/c1-9(25)23-12(6-14(26)27)18(31)21-7-10-3-4-13-11(5-10)17(30)16(20(33)24(13)2)19(32)22-8-15(28)29/h3-5,12,30H,6-8H2,1-2H3,(H,21,31)(H,22,32)(H,23,25)(H,26,27)(H,28,29)/t12-/s2
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n/an/a 138n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93417
PNG
(PHD Inhibitor, 8{7})
Show SMILES CC(=O)N[C@@H](CCCCN)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1/C22H29N5O7/c1-12(28)26-15(5-3-4-8-23)20(32)24-10-13-6-7-16-14(9-13)19(31)18(22(34)27(16)2)21(33)25-11-17(29)30/h6-7,9,15,31H,3-5,8,10-11,23H2,1-2H3,(H,24,32)(H,25,33)(H,26,28)(H,29,30)/t15-/s2
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n/an/a 409n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93418
PNG
(PHD Inhibitor, 12{2,3,1})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)C[C@H](Cc3ccccc3)NC(=O)c3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1/C40H39N5O8/c1-45-32-18-17-27(20-30(32)36(49)35(40(45)53)39(52)42-24-34(47)48)23-41-38(51)31(21-26-13-7-3-8-14-26)44-33(46)22-29(19-25-11-5-2-6-12-25)43-37(50)28-15-9-4-10-16-28/h2-18,20,29,31,49H,19,21-24H2,1H3,(H,41,51)(H,42,52)(H,43,50)(H,44,46)(H,47,48)/t29-,31+/s2
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n/an/a 1.56E+3n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93419
PNG
(PHD Inhibitor, 12{2,4,1})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)c3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1/C39H37N5O8/c1-44-31-18-17-26(19-28(31)34(47)33(39(44)52)38(51)41-23-32(45)46)22-40-36(49)29(20-24-11-5-2-6-12-24)43-37(50)30(21-25-13-7-3-8-14-25)42-35(48)27-15-9-4-10-16-27/h2-19,29-30,47H,20-23H2,1H3,(H,40,49)(H,41,51)(H,42,48)(H,43,50)(H,45,46)/t29-,30-/s2
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n/an/a 622n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93420
PNG
(PHD Inhibitor, 12{3,1,4})
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)C(C)(C)C)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1/C38H45N5O8/c1-21(2)16-27(41-34(48)28(42-37(51)38(3,4)5)18-24-12-9-11-23-10-7-8-13-25(23)24)33(47)39-19-22-14-15-29-26(17-22)32(46)31(36(50)43(29)6)35(49)40-20-30(44)45/h7-15,17,21,27-28,46H,16,18-20H2,1-6H3,(H,39,47)(H,40,49)(H,41,48)(H,42,51)(H,44,45)/t27-,28-/s2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93421
PNG
(PHD Inhibitor, 12{1,5,3})
Show SMILES Cn1c2ccc(CNC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCOCC3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1/C39H44N6O9/c1-44-31-13-12-27(20-28(31)35(49)34(39(44)53)38(52)41-24-33(47)48)23-40-36(50)29(21-25-8-4-2-5-9-25)43-37(51)30(22-26-10-6-3-7-11-26)42-32(46)14-15-45-16-18-54-19-17-45/h2-13,20,29-30,49H,14-19,21-24H2,1H3,(H,40,50)(H,41,52)(H,42,46)(H,43,51)(H,47,48)/t29-,30-/s2
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n/an/a 2.92E+3n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93422
PNG
(PHD Inhibitor, 12{1,1,2})
Show SMILES CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1/C38H37N5O8/c1-22(44)41-30(19-24-12-14-26-10-6-7-11-27(26)16-24)36(49)42-29(18-23-8-4-3-5-9-23)35(48)39-20-25-13-15-31-28(17-25)34(47)33(38(51)43(31)2)37(50)40-21-32(45)46/h3-17,29-30,47H,18-21H2,1-2H3,(H,39,48)(H,40,50)(H,41,44)(H,42,49)(H,45,46)/t29-,30-/s2
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n/an/a 35n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93423
PNG
(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26-/s2
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n/an/a 37.4n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93419
PNG
(PHD Inhibitor, 12{2,4,1})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)c3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1/C39H37N5O8/c1-44-31-18-17-26(19-28(31)34(47)33(39(44)52)38(51)41-23-32(45)46)22-40-36(49)29(20-24-11-5-2-6-12-24)43-37(50)30(21-25-13-7-3-8-14-25)42-35(48)27-15-9-4-10-16-27/h2-19,29-30,47H,20-23H2,1H3,(H,40,49)(H,41,51)(H,42,48)(H,43,50)(H,45,46)/t29-,30-/s2
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n/an/a 38.3n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93425
PNG
(PHD Inhibitor, 12{4,1,2})
Show SMILES CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)NCC(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1/C31H31N5O8/c1-17(37)35-23(13-18-7-9-20-5-3-4-6-21(20)11-18)29(42)33-15-25(38)32-14-19-8-10-24-22(12-19)28(41)27(31(44)36(24)2)30(43)34-16-26(39)40/h3-12,23,41H,13-16H2,1-2H3,(H,32,38)(H,33,42)(H,34,43)(H,35,37)(H,39,40)/t23-/s2
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n/an/a 41.9n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93426
PNG
(PHD Inhibitor, 12{2,5,2})
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26+/s2
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n/an/a 44.8n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93427
PNG
(PHD Inhibitor, 12{2,6,2})
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1/C31H37N5O8/c1-17(2)12-22(34-18(3)37)29(42)35-23(14-19-8-6-5-7-9-19)28(41)32-15-20-10-11-24-21(13-20)27(40)26(31(44)36(24)4)30(43)33-16-25(38)39/h5-11,13,17,22-23,40H,12,14-16H2,1-4H3,(H,32,41)(H,33,43)(H,34,37)(H,35,42)(H,38,39)/t22-,23+/s2
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n/an/a 67.5n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93428
PNG
(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1/C37H41N5O8/c1-37(2,3)36(50)41-27(19-23-13-9-6-10-14-23)33(47)40-26(18-22-11-7-5-8-12-22)32(46)38-20-24-15-16-28-25(17-24)31(45)30(35(49)42(28)4)34(48)39-21-29(43)44/h5-17,26-27,45H,18-21H2,1-4H3,(H,38,46)(H,39,48)(H,40,47)(H,41,50)(H,43,44)/t26-,27-/s2
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n/an/a 86.4n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93423
PNG
(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26-/s2
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n/an/a 90.2n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93430
PNG
(PHD Inhibitor, 12{2,1,2})
Show SMILES CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1/C38H37N5O8/c1-22(44)41-30(19-24-12-14-26-10-6-7-11-27(26)16-24)36(49)42-29(18-23-8-4-3-5-9-23)35(48)39-20-25-13-15-31-28(17-25)34(47)33(38(51)43(31)2)37(50)40-21-32(45)46/h3-17,29-30,47H,18-21H2,1-2H3,(H,39,48)(H,40,50)(H,41,44)(H,42,49)(H,45,46)/t29-,30-/s2
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n/an/a 93.8n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93428
PNG
(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1/C37H41N5O8/c1-37(2,3)36(50)41-27(19-23-13-9-6-10-14-23)33(47)40-26(18-22-11-7-5-8-12-22)32(46)38-20-24-15-16-28-25(17-24)31(45)30(35(49)42(28)4)34(48)39-21-29(43)44/h5-17,26-27,45H,18-21H2,1-4H3,(H,38,46)(H,39,48)(H,40,47)(H,41,50)(H,43,44)/t26-,27-/s2
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n/an/a 104n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93432
PNG
(PHD Inhibitor, 12{2,6,4})
Show SMILES CC(C)C[C@@H](NC(=O)C(C)(C)C)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1/C34H43N5O8/c1-19(2)14-23(38-33(47)34(3,4)5)30(44)37-24(16-20-10-8-7-9-11-20)29(43)35-17-21-12-13-25-22(15-21)28(42)27(32(46)39(25)6)31(45)36-18-26(40)41/h7-13,15,19,23-24,42H,14,16-18H2,1-6H3,(H,35,43)(H,36,45)(H,37,44)(H,38,47)(H,40,41)/t23-,24-/s2
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n/an/a 113n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
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