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Compile Data Set for Download or QSAR

Found 132 hits Enz. Inhib. hit(s) with Target = 'Egl nine homolog 3'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 3


(Homo sapiens (Human))
BDBM50446879
PNG
(CHEMBL3115287)
Show SMILES OC(=O)CNC(=O)c1c(O)c(cn(Cc2ccccc2)c1=O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C23H21N3O6/c27-18(28)12-25-22(31)19-20(29)17(21(30)24-11-15-7-3-1-4-8-15)14-26(23(19)32)13-16-9-5-2-6-10-16/h1-10,14,29H,11-13H2,(H,24,30)(H,25,31)(H,27,28)
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n/an/an/an/a 1n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISA


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM50446878
PNG
(CHEMBL3115288)
Show SMILES OC(=O)CNC(=O)c1c(O)c(C(=O)NCc2ccccc2)c(O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H21N3O7/c27-16(28)12-25-21(31)18-19(29)17(20(30)24-11-14-7-3-1-4-8-14)22(32)26(23(18)33)13-15-9-5-2-6-10-15/h1-10,29,32H,11-13H2,(H,24,30)(H,25,31)(H,27,28)
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n/an/an/an/a 1n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISA


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM50446906
PNG
(CHEMBL3115290)
Show SMILES OC(=O)CNC(=O)c1c(O)c(cc2nccnc12)-c1cccnc1
Show InChI InChI=1S/C16H12N4O4/c21-12(22)8-20-16(24)13-14-11(18-4-5-19-14)6-10(15(13)23)9-2-1-3-17-7-9/h1-7,23H,8H2,(H,20,24)(H,21,22)
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n/an/an/an/a 100n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISA


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM50446882
PNG
(CHEMBL3115284)
Show SMILES CC(C)(C)c1ccc(Cn2nc(c(O)c(C(=O)NCC(O)=O)c2=O)-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C24H24ClN3O5/c1-24(2,3)16-8-4-14(5-9-16)13-28-23(33)19(22(32)26-12-18(29)30)21(31)20(27-28)15-6-10-17(25)11-7-15/h4-11,31H,12-13H2,1-3H3,(H,26,32)(H,29,30)
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n/an/an/an/a 400n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISA


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM50446883
PNG
(CHEMBL3115283)
Show SMILES CC(C)(C)c1ccc(Cn2c(nc(O)c(C(=O)NCC(O)=O)c2=O)-c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C24H23Cl2N3O5/c1-24(2,3)14-9-7-13(8-10-14)12-29-20(18-15(25)5-4-6-16(18)26)28-22(33)19(23(29)34)21(32)27-11-17(30)31/h4-10,33H,11-12H2,1-3H3,(H,27,32)(H,30,31)
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n/an/an/an/a 400n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISA


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM50446884
PNG
(CHEMBL3115282)
Show SMILES OC(=O)CNC(=O)c1c(O)n(Cc2ccccc2C#N)c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H18N4O6/c23-10-15-8-4-5-9-16(15)13-26-21(31)18(19(29)24-11-17(27)28)20(30)25(22(26)32)12-14-6-2-1-3-7-14/h1-9,31H,11-13H2,(H,24,29)(H,27,28)
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n/an/an/an/a 400n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISA


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM50446902
PNG
(CHEMBL3115294)
Show SMILES COc1ccc(nc1OC)-n1c(=S)[nH]c2sc(C(=O)NCc3ccc(Cl)cc3)c(C)c2c1=O
Show InChI InChI=1S/C22H19ClN4O4S2/c1-11-16-20(33-17(11)18(28)24-10-12-4-6-13(23)7-5-12)26-22(32)27(21(16)29)15-9-8-14(30-2)19(25-15)31-3/h4-9H,10H2,1-3H3,(H,24,28)(H,26,32)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISA


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM50446887
PNG
(CHEMBL3115295)
Show SMILES COc1ccc(nc1OC)-n1c(=O)[nH]c2cc(sc2c1=O)C(=O)NCc1ccc2OCOc2c1
Show InChI InChI=1S/C22H18N4O7S/c1-30-14-5-6-17(25-20(14)31-2)26-21(28)18-12(24-22(26)29)8-16(34-18)19(27)23-9-11-3-4-13-15(7-11)33-10-32-13/h3-8H,9-10H2,1-2H3,(H,23,27)(H,24,29)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISA


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM50446903
PNG
(CHEMBL3115293)
Show SMILES COc1ccc(nc1OC)-n1c(=S)[nH]c2cc(sc2c1=O)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H17ClN4O4S2/c1-29-14-7-8-16(25-19(14)30-2)26-20(28)17-13(24-21(26)31)9-15(32-17)18(27)23-10-11-3-5-12(22)6-4-11/h3-9H,10H2,1-2H3,(H,23,27)(H,24,31)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISA


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM50446901
PNG
(CHEMBL3115296)
Show SMILES COc1ccc(nc1OC)-n1c(=O)[nH]c2cc(ncc2c1=O)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C22H18ClN5O5/c1-32-17-7-8-18(27-20(17)33-2)28-21(30)14-11-24-16(9-15(14)26-22(28)31)19(29)25-10-12-3-5-13(23)6-4-12/h3-9,11H,10H2,1-2H3,(H,25,29)(H,26,31)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISA


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM50446880
PNG
(CHEMBL3115286)
Show SMILES Cc1c(C)n(Cc2ccccc2)c(=O)c(C(=O)NCC(O)=O)c1O
Show InChI InChI=1S/C17H18N2O5/c1-10-11(2)19(9-12-6-4-3-5-7-12)17(24)14(15(10)22)16(23)18-8-13(20)21/h3-7,22H,8-9H2,1-2H3,(H,18,23)(H,20,21)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISA


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM50446881
PNG
(CHEMBL3115285)
Show SMILES OC(=O)CNC(=O)c1c(O)nc2ccccn2c1=O
Show InChI InChI=1S/C11H9N3O5/c15-7(16)5-12-9(17)8-10(18)13-6-3-1-2-4-14(6)11(8)19/h1-4,18H,5H2,(H,12,17)(H,15,16)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISA


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM93418
PNG
(PHD Inhibitor, 12{2,3,1})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)C[C@H](Cc3ccccc3)NC(=O)c3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C40H39N5O8/c1-45-32-18-17-27(20-30(32)36(49)35(40(45)53)39(52)42-24-34(47)48)23-41-38(51)31(21-26-13-7-3-8-14-26)44-33(46)22-29(19-25-11-5-2-6-12-25)43-37(50)28-15-9-4-10-16-28/h2-18,20,29,31,49H,19,21-24H2,1H3,(H,41,51)(H,42,52)(H,43,50)(H,44,46)(H,47,48)/t29-,31+/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Amgen, Inc.



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM93419
PNG
(PHD Inhibitor, 12{2,4,1})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)c3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C39H37N5O8/c1-44-31-18-17-26(19-28(31)34(47)33(39(44)52)38(51)41-23-32(45)46)22-40-36(49)29(20-24-11-5-2-6-12-24)43-37(50)30(21-25-13-7-3-8-14-25)42-35(48)27-15-9-4-10-16-27/h2-19,29-30,47H,20-23H2,1H3,(H,40,49)(H,41,51)(H,42,48)(H,43,50)(H,45,46)/t29-,30-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Amgen, Inc.



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM93420
PNG
(PHD Inhibitor, 12{3,1,4})
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)C(C)(C)C)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C38H45N5O8/c1-21(2)16-27(41-34(48)28(42-37(51)38(3,4)5)18-24-12-9-11-23-10-7-8-13-25(23)24)33(47)39-19-22-14-15-29-26(17-22)32(46)31(36(50)43(29)6)35(49)40-20-30(44)45/h7-15,17,21,27-28,46H,16,18-20H2,1-6H3,(H,39,47)(H,40,49)(H,41,48)(H,42,51)(H,44,45)/t27-,28-/m0/s1
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n/an/a 77n/an/an/an/an/an/a



Amgen, Inc.



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM93421
PNG
(PHD Inhibitor, 12{1,5,3})
Show SMILES Cn1c2ccc(CNC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCOCC3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C39H44N6O9/c1-44-31-13-12-27(20-28(31)35(49)34(39(44)53)38(52)41-24-33(47)48)23-40-36(50)29(21-25-8-4-2-5-9-25)43-37(51)30(22-26-10-6-3-7-11-26)42-32(46)14-15-45-16-18-54-19-17-45/h2-13,20,29-30,49H,14-19,21-24H2,1H3,(H,40,50)(H,41,52)(H,42,46)(H,43,51)(H,47,48)/t29-,30-/m0/s1
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n/an/a 165n/an/an/an/an/an/a



Amgen, Inc.



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM93422
PNG
(PHD Inhibitor, 12{1,1,2})
Show SMILES CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C38H37N5O8/c1-22(44)41-30(19-24-12-14-26-10-6-7-11-27(26)16-24)36(49)42-29(18-23-8-4-3-5-9-23)35(48)39-20-25-13-15-31-28(17-25)34(47)33(38(51)43(31)2)37(50)40-21-32(45)46/h3-17,29-30,47H,18-21H2,1-2H3,(H,39,48)(H,40,50)(H,41,44)(H,42,49)(H,45,46)/t29-,30-/m0/s1
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n/an/a 4.5n/an/an/an/an/an/a



Amgen, Inc.



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM93423
PNG
(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26-/m1/s1
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n/an/a 11.7n/an/an/an/an/an/a



Amgen, Inc.



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM93419
PNG
(PHD Inhibitor, 12{2,4,1})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)c3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C39H37N5O8/c1-44-31-18-17-26(19-28(31)34(47)33(39(44)52)38(51)41-23-32(45)46)22-40-36(49)29(20-24-11-5-2-6-12-24)43-37(50)30(21-25-13-7-3-8-14-25)42-35(48)27-15-9-4-10-16-27/h2-19,29-30,47H,20-23H2,1H3,(H,40,49)(H,41,51)(H,42,48)(H,43,50)(H,45,46)/t29-,30-/m1/s1
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n/an/a 5.30n/an/an/an/an/an/a



Amgen, Inc.



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM93425
PNG
(PHD Inhibitor, 12{4,1,2})
Show SMILES CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)NCC(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C31H31N5O8/c1-17(37)35-23(13-18-7-9-20-5-3-4-6-21(20)11-18)29(42)33-15-25(38)32-14-19-8-10-24-22(12-19)28(41)27(31(44)36(24)2)30(43)34-16-26(39)40/h3-12,23,41H,13-16H2,1-2H3,(H,32,38)(H,33,42)(H,34,43)(H,35,37)(H,39,40)/t23-/m0/s1
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n/an/a 13.5n/an/an/an/an/an/a



Amgen, Inc.



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM93426
PNG
(PHD Inhibitor, 12{2,5,2})
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26+/m1/s1
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n/an/a 8.90n/an/an/an/an/an/a



Amgen, Inc.



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM93427
PNG
(PHD Inhibitor, 12{2,6,2})
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C31H37N5O8/c1-17(2)12-22(34-18(3)37)29(42)35-23(14-19-8-6-5-7-9-19)28(41)32-15-20-10-11-24-21(13-20)27(40)26(31(44)36(24)4)30(43)33-16-25(38)39/h5-11,13,17,22-23,40H,12,14-16H2,1-4H3,(H,32,41)(H,33,43)(H,34,37)(H,35,42)(H,38,39)/t22-,23+/m0/s1
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n/an/a 16.2n/an/an/an/an/an/a



Amgen, Inc.



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM93428
PNG
(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C37H41N5O8/c1-37(2,3)36(50)41-27(19-23-13-9-6-10-14-23)33(47)40-26(18-22-11-7-5-8-12-22)32(46)38-20-24-15-16-28-25(17-24)31(45)30(35(49)42(28)4)34(48)39-21-29(43)44/h5-17,26-27,45H,18-21H2,1-4H3,(H,38,46)(H,39,48)(H,40,47)(H,41,50)(H,43,44)/t26-,27-/m1/s1
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n/an/a 12.6n/an/an/an/an/an/a



Amgen, Inc.



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM93423
PNG
(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26-/m1/s1
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n/an/a 13.5n/an/an/an/an/an/a



Amgen, Inc.



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM93430
PNG
(PHD Inhibitor, 12{2,1,2})
Show SMILES CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C38H37N5O8/c1-22(44)41-30(19-24-12-14-26-10-6-7-11-27(26)16-24)36(49)42-29(18-23-8-4-3-5-9-23)35(48)39-20-25-13-15-31-28(17-25)34(47)33(38(51)43(31)2)37(50)40-21-32(45)46/h3-17,29-30,47H,18-21H2,1-2H3,(H,39,48)(H,40,50)(H,41,44)(H,42,49)(H,45,46)/t29-,30-/m1/s1
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n/an/a 6.40n/an/an/an/an/an/a



Amgen, Inc.



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM93428
PNG
(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C37H41N5O8/c1-37(2,3)36(50)41-27(19-23-13-9-6-10-14-23)33(47)40-26(18-22-11-7-5-8-12-22)32(46)38-20-24-15-16-28-25(17-24)31(45)30(35(49)42(28)4)34(48)39-21-29(43)44/h5-17,26-27,45H,18-21H2,1-4H3,(H,38,46)(H,39,48)(H,40,47)(H,41,50)(H,43,44)/t26-,27-/m1/s1
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n/an/a 13.2n/an/an/an/an/an/a



Amgen, Inc.



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM93432
PNG
(PHD Inhibitor, 12{2,6,4})
Show SMILES CC(C)C[C@@H](NC(=O)C(C)(C)C)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H43N5O8/c1-19(2)14-23(38-33(47)34(3,4)5)30(44)37-24(16-20-10-8-7-9-11-20)29(43)35-17-21-12-13-25-22(15-21)28(42)27(32(46)39(25)6)31(45)36-18-26(40)41/h7-13,15,19,23-24,42H,14,16-18H2,1-6H3,(H,35,43)(H,36,45)(H,37,44)(H,38,47)(H,40,41)/t23-,24-/m1/s1
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n/an/a 16.8n/an/an/an/an/an/a



Amgen, Inc.



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM93433
PNG
(PHD Inhibitor, 12{2,1,4})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc4ccccc4c3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C41H43N5O8/c1-41(2,3)40(54)45-31(21-25-14-16-27-12-8-9-13-28(27)18-25)37(51)44-30(20-24-10-6-5-7-11-24)36(50)42-22-26-15-17-32-29(19-26)35(49)34(39(53)46(32)4)38(52)43-23-33(47)48/h5-19,30-31,49H,20-23H2,1-4H3,(H,42,50)(H,43,52)(H,44,51)(H,45,54)(H,47,48)/t30-,31-/m1/s1
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n/an/a 18.8n/an/an/an/an/an/a



Amgen, Inc.



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107695
PNG
(US8598210, Table XV, 1 | US8722895, 1: {[5-(3-chlo...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-10(7-17-14)9-3-2-4-11(16)5-9/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/a 2.14E+4n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107698
PNG
(US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...)
Show SMILES Cc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C15H14N2O4/c1-9-2-4-10(5-3-9)11-6-12(18)14(16-7-11)15(21)17-8-13(19)20/h2-7,18H,8H2,1H3,(H,17,21)(H,19,20)
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n/an/a 180n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107700
PNG
(US8598210, Table XV, 6 | US8722895, 6: [(3-Hydroxy...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(C)cc1
Show InChI InChI=1S/C16H16N2O4/c1-10-3-5-11(6-4-10)12-7-13(19)15(17-8-12)16(21)18-9-14(20)22-2/h3-8,19H,9H2,1-2H3,(H,18,21)
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n/an/a 5.23E+4n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107701
PNG
(US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/a 3.75E+4n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107702
PNG
(US8598210, Table XV, 8 | US8722895, 8: {[5-(4-Cyan...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)[N+]#[C-]
Show InChI InChI=1S/C15H11N3O4/c1-16-11-4-2-9(3-5-11)10-6-12(19)14(17-7-10)15(22)18-8-13(20)21/h2-7,19H,8H2,(H,18,22)(H,20,21)
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n/an/a 560n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107703
PNG
(US8598210, Table XV, 9 | US8722895, 9: {[5-(4-Chlo...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 83n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107704
PNG
(US8598210, 119 | US8598210, Table XV, 10 | US85982...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 390n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107706
PNG
(US8598210, Table XV, 12 | US8722895, 12: {[5-(2-Ch...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C14H11ClN2O4/c15-10-4-2-1-3-9(10)8-5-11(18)13(16-6-8)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 390n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107711
PNG
(US8598210, Table XV, 17 | US8722895, 17: 5-(3-Chlo...)
Show SMILES CNC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H14ClN3O3/c1-17-13(21)8-19-15(22)14-12(20)6-10(7-18-14)9-3-2-4-11(16)5-9/h2-7,20H,8H2,1H3,(H,17,21)(H,19,22)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107695
PNG
(US8598210, Table XV, 1 | US8722895, 1: {[5-(3-chlo...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-10(7-17-14)9-3-2-4-11(16)5-9/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/a 2.14E+4n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107698
PNG
(US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...)
Show SMILES Cc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C15H14N2O4/c1-9-2-4-10(5-3-9)11-6-12(18)14(16-7-11)15(21)17-8-13(19)20/h2-7,18H,8H2,1H3,(H,17,21)(H,19,20)
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n/an/a 180n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107700
PNG
(US8598210, Table XV, 6 | US8722895, 6: [(3-Hydroxy...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(C)cc1
Show InChI InChI=1S/C16H16N2O4/c1-10-3-5-11(6-4-10)12-7-13(19)15(17-8-12)16(21)18-9-14(20)22-2/h3-8,19H,9H2,1-2H3,(H,18,21)
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n/an/a 5.23E+4n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107701
PNG
(US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/a 3.75E+4n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107702
PNG
(US8598210, Table XV, 8 | US8722895, 8: {[5-(4-Cyan...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)[N+]#[C-]
Show InChI InChI=1S/C15H11N3O4/c1-16-11-4-2-9(3-5-11)10-6-12(19)14(17-7-10)15(22)18-8-13(20)21/h2-7,19H,8H2,(H,18,22)(H,20,21)
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n/an/a 560n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107703
PNG
(US8598210, Table XV, 9 | US8722895, 9: {[5-(4-Chlo...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 83n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107704
PNG
(US8598210, 119 | US8598210, Table XV, 10 | US85982...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 390n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107706
PNG
(US8598210, Table XV, 12 | US8722895, 12: {[5-(2-Ch...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C14H11ClN2O4/c15-10-4-2-1-3-9(10)8-5-11(18)13(16-6-8)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 390n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107711
PNG
(US8598210, Table XV, 17 | US8722895, 17: 5-(3-Chlo...)
Show SMILES CNC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H14ClN3O3/c1-17-13(21)8-19-15(22)14-12(20)6-10(7-18-14)9-3-2-4-11(16)5-9/h2-7,20H,8H2,1H3,(H,17,21)(H,19,22)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM50446884
PNG
(CHEMBL3115282)
Show SMILES OC(=O)CNC(=O)c1c(O)n(Cc2ccccc2C#N)c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H18N4O6/c23-10-15-8-4-5-9-16(15)13-26-21(31)18(19(29)24-11-17(27)28)20(30)25(22(26)32)12-14-6-2-1-3-7-14/h1-9,31H,11-13H2,(H,24,29)(H,27,28)
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n/an/a 0.800n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli after 30 mins


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM50446887
PNG
(CHEMBL3115295)
Show SMILES COc1ccc(nc1OC)-n1c(=O)[nH]c2cc(sc2c1=O)C(=O)NCc1ccc2OCOc2c1
Show InChI InChI=1S/C22H18N4O7S/c1-30-14-5-6-17(25-20(14)31-2)26-21(28)18-12(24-22(26)29)8-16(34-18)19(27)23-9-11-3-4-13-15(7-11)33-10-32-13/h3-8H,9-10H2,1-2H3,(H,23,27)(H,24,29)
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n/an/a 1n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM50446903
PNG
(CHEMBL3115293)
Show SMILES COc1ccc(nc1OC)-n1c(=S)[nH]c2cc(sc2c1=O)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H17ClN4O4S2/c1-29-14-7-8-16(25-19(14)30-2)26-20(28)17-13(24-21(26)31)9-15(32-17)18(27)23-10-11-3-5-12(22)6-4-11/h3-9H,10H2,1-2H3,(H,23,27)(H,24,31)
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n/an/a 1n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM50446902
PNG
(CHEMBL3115294)
Show SMILES COc1ccc(nc1OC)-n1c(=S)[nH]c2sc(C(=O)NCc3ccc(Cl)cc3)c(C)c2c1=O
Show InChI InChI=1S/C22H19ClN4O4S2/c1-11-16-20(33-17(11)18(28)24-10-12-4-6-13(23)7-5-12)26-22(32)27(21(16)29)15-9-8-14(30-2)19(25-15)31-3/h4-9H,10H2,1-3H3,(H,24,28)(H,26,32)
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n/an/a 1n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
BindingDB Entry DOI: 10.7270/Q290258T
More data for this
Ligand-Target Pair
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