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Compile Data Set for Download or QSAR

Found 2495 hits Enz. Inhib. hit(s) with Target = 'Ephrin receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ephrin type-A receptor 3 (EPHA3)


(Homo sapiens (Human))
BDBM50242740
PNG
(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)
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n/an/an/an/a 2n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of EphA3 by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50242740
PNG
(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)
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n/an/an/an/a 4n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of EphB4 by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Ephrin receptor


(Homo sapiens)
BDBM50297825
PNG
(5-(2-methyl-5-(3-(trifluoromethyl)phenylcarbamoyl)...)
Show SMILES Cc1ccc(cc1Nc1cncc(c1)C(N)=O)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H17F3N4O2/c1-12-5-6-13(8-18(12)27-17-7-14(19(25)29)10-26-11-17)20(30)28-16-4-2-3-15(9-16)21(22,23)24/h2-11,27H,1H3,(H2,25,29)(H,28,30)
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n/an/an/an/a 40n/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Inhibition of EphB2


Bioorg Med Chem Lett 19: 4467-70 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.029
BindingDB Entry DOI: 10.7270/Q2V69JN0
More data for this
Ligand-Target Pair
Ephrin receptor


(Homo sapiens)
BDBM50297824
PNG
(CHEMBL559058 | N-(2-methyl-5-(3-(4-methyl-1H-imida...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(NC(=O)c3ccno3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C23H18F3N5O3/c1-13-3-4-15(7-19(13)30-22(33)20-5-6-28-34-20)21(32)29-17-8-16(23(24,25)26)9-18(10-17)31-11-14(2)27-12-31/h3-12H,1-2H3,(H,29,32)(H,30,33)
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n/an/an/an/a 40n/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Inhibition of EphB2


Bioorg Med Chem Lett 19: 4467-70 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.029
BindingDB Entry DOI: 10.7270/Q2V69JN0
More data for this
Ligand-Target Pair
Ephrin receptor


(Homo sapiens)
BDBM50297825
PNG
(5-(2-methyl-5-(3-(trifluoromethyl)phenylcarbamoyl)...)
Show SMILES Cc1ccc(cc1Nc1cncc(c1)C(N)=O)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H17F3N4O2/c1-12-5-6-13(8-18(12)27-17-7-14(19(25)29)10-26-11-17)20(30)28-16-4-2-3-15(9-16)21(22,23)24/h2-11,27H,1H3,(H2,25,29)(H,28,30)
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n/an/an/an/a 100n/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Inhibition of ephrinB1-induced autophosphorylation of EphB2 expressed in human U87 cells after 1 hr by western blot analysis


Bioorg Med Chem Lett 19: 4467-70 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.029
BindingDB Entry DOI: 10.7270/Q2V69JN0
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50242742
PNG
(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of EphB4 by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Ephrin type-A receptor 3 (EPHA3)


(Homo sapiens (Human))
BDBM50242742
PNG
(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of EphA3 by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
EPH receptor B2


(Homo sapiens)
BDBM50237710
PNG
(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
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4n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 103: 3153-8 (2006)


Article DOI: 10.1073/pnas.0511292103
BindingDB Entry DOI: 10.7270/Q21Z430B
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50376901
PNG
(CHEMBL256101 | TG-100855)
Show SMILES Cc1cc(cc2nnc(Nc3ccc(OCC[N+]4([O-])CCCC4)cc3)nc12)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C26H25Cl2N5O2/c1-17-15-18(24-21(27)5-4-6-22(24)28)16-23-25(17)30-26(32-31-23)29-19-7-9-20(10-8-19)35-14-13-33(34)11-2-3-12-33/h4-10,15-16H,2-3,11-14H2,1H3,(H,29,30,32)
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7.27n/an/an/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 by luminescence based kinase assay


Drug Metab Dispos 35: 929-36 (2007)


Article DOI: 10.1124/dmd.106.014290
BindingDB Entry DOI: 10.7270/Q2CV4JMV
More data for this
Ligand-Target Pair
EPHB1


(HUMAN)
BDBM50237710
PNG
(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
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15n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 103: 3153-8 (2006)


Article DOI: 10.1073/pnas.0511292103
BindingDB Entry DOI: 10.7270/Q21Z430B
More data for this
Ligand-Target Pair
EPHB4


(Homo sapiens (Human))
BDBM50237710
PNG
(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
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37n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 103: 3153-8 (2006)


Article DOI: 10.1073/pnas.0511292103
BindingDB Entry DOI: 10.7270/Q21Z430B
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50198782
PNG
(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Show SMILES Cc1cc(cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C26H25Cl2N5O/c1-17-15-18(24-21(27)5-4-6-22(24)28)16-23-25(17)30-26(32-31-23)29-19-7-9-20(10-8-19)34-14-13-33-11-2-3-12-33/h4-10,15-16H,2-3,11-14H2,1H3,(H,29,30,32)
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63.8n/an/an/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 by luminescence based kinase assay


Drug Metab Dispos 35: 929-36 (2007)


Article DOI: 10.1124/dmd.106.014290
BindingDB Entry DOI: 10.7270/Q2CV4JMV
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50198782
PNG
(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Show SMILES Cc1cc(cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C26H25Cl2N5O/c1-17-15-18(24-21(27)5-4-6-22(24)28)16-23-25(17)30-26(32-31-23)29-19-7-9-20(10-8-19)34-14-13-33-11-2-3-12-33/h4-10,15-16H,2-3,11-14H2,1H3,(H,29,30,32)
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63.8n/an/an/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4


Bioorg Med Chem Lett 17: 602-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.006
BindingDB Entry DOI: 10.7270/Q29024MW
More data for this
Ligand-Target Pair
Ephrin receptor


(Homo sapiens)
BDBM50341519
PNG
((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Show SMILES CNc1cncc(n1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1
Show InChI InChI=1S/C26H31N7O2/c1-27-24-16-28-15-23(30-24)19-13-22(26(35)29-14-19)31-25(34)18-6-8-20(9-7-18)33-12-4-5-21(33)17-32-10-2-3-11-32/h6-9,13-16,21H,2-5,10-12,17H2,1H3,(H,27,30)(H,29,35)(H,31,34)/t21-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of EPHB2


J Med Chem 54: 2341-50 (2011)


Article DOI: 10.1021/jm101499u
BindingDB Entry DOI: 10.7270/Q2KH0NPW
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50205468
PNG
((Z)-2-amino-5-(quinolin-6-ylmethylene)thiazol-4(5H...)
Show SMILES NC1=NC(=O)C(S1)=Cc1ccc2ncccc2c1
Show InChI InChI=1S/C13H9N3OS/c14-13-16-12(17)11(18-13)7-8-3-4-10-9(6-8)2-1-5-15-10/h1-7H,(H2,14,16,17)
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>2.00E+3n/an/an/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibition of EPHB3


Bioorg Med Chem Lett 17: 2134-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.081
BindingDB Entry DOI: 10.7270/Q2BV7G9T
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50205472
PNG
((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Show SMILES O=C1N=C(NCc2cccs2)SC1=Cc1ccc2ncccc2c1
Show InChI InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)
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>2.00E+3n/an/an/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibition of EPHB3


Bioorg Med Chem Lett 17: 2134-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.081
BindingDB Entry DOI: 10.7270/Q2BV7G9T
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50205477
PNG
((Z)-2-((1R,2S)-2-phenylcyclopropylamino)-5-(quinol...)
Show SMILES O=C1N=C(N[C@@H]2C[C@H]2c2ccccc2)SC1=Cc1ccc2ncccc2c1
Show InChI InChI=1S/C22H17N3OS/c26-21-20(12-14-8-9-18-16(11-14)7-4-10-23-18)27-22(25-21)24-19-13-17(19)15-5-2-1-3-6-15/h1-12,17,19H,13H2,(H,24,25,26)/t17-,19+/m0/s1
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>2.00E+3n/an/an/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibition of EPHB3


Bioorg Med Chem Lett 17: 2134-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.081
BindingDB Entry DOI: 10.7270/Q2BV7G9T
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50205472
PNG
((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Show SMILES O=C1N=C(NCc2cccs2)SC1=Cc1ccc2ncccc2c1
Show InChI InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)
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>2.00E+3n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of EphB3


Proc Natl Acad Sci USA 104: 20523-8 (2007)

Checked by Author
Article DOI: 10.1073/pnas.0708800104
BindingDB Entry DOI: 10.7270/Q2DB82RH
More data for this
Ligand-Target Pair
Ephrin receptor


(Homo sapiens)
BDBM50402020
PNG
(CHEMBL2205426)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O
Show InChI InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-13-25-22(28-17)26-16-6-4-14(5-7-16)15-8-11-24-12-9-15/h4-13,29H,1-3H3,(H2,25,26,27,28)
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PubMed
>2.80E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant EPHA2 after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATP


Bioorg Med Chem Lett 22: 7615-22 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.009
BindingDB Entry DOI: 10.7270/Q2XK8GQ3
More data for this
Ligand-Target Pair
Ephrin receptor


(Homo sapiens)
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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PubMed
>8.00E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EPHA2


Bioorg Med Chem Lett 17: 6593-601 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT
More data for this
Ligand-Target Pair
EPHB4


(Homo sapiens (Human))
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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>1.00E+4n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 103: 3153-8 (2006)


Article DOI: 10.1073/pnas.0511292103
BindingDB Entry DOI: 10.7270/Q21Z430B
More data for this
Ligand-Target Pair
EPH receptor B2


(Homo sapiens)
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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>1.00E+4n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 103: 3153-8 (2006)


Article DOI: 10.1073/pnas.0511292103
BindingDB Entry DOI: 10.7270/Q21Z430B
More data for this
Ligand-Target Pair
EPHB1


(HUMAN)
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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>1.00E+4n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 103: 3153-8 (2006)


Article DOI: 10.1073/pnas.0511292103
BindingDB Entry DOI: 10.7270/Q21Z430B
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM6219
PNG
(BMCL182776 Compound 1 | Chlorobenzodioxole deriv. ...)
Show SMILES COc1cc2c(Nc3c4OCOc4ccc3Cl)ncnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C24H27ClN4O4/c1-30-20-12-16-18(13-21(20)31-11-5-10-29-8-3-2-4-9-29)26-14-27-24(16)28-22-17(25)6-7-19-23(22)33-15-32-19/h6-7,12-14H,2-5,8-11,15H2,1H3,(H,26,27,28)
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n/an/a 350n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25202
PNG
(2-N-(3-chloro-4-methoxyphenyl)-4-N-(3,4,5-trimetho...)
Show SMILES COc1ccc(Nc2ncnc(Nc3cc(OC)c(OC)c(OC)c3)n2)cc1Cl
Show InChI InChI=1S/C19H20ClN5O4/c1-26-14-6-5-11(7-13(14)20)23-18-21-10-22-19(25-18)24-12-8-15(27-2)17(29-4)16(9-12)28-3/h5-10H,1-4H3,(H2,21,22,23,24,25)
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n/an/a 1.60E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25203
PNG
(2-N-(5-chloro-2H-1,3-benzodioxol-4-yl)-4-N-(3,4,5-...)
Show SMILES COc1cc(Nc2ncnc(Nc3c4OCOc4ccc3Cl)n2)cc(OC)c1OC
Show InChI InChI=1S/C19H18ClN5O5/c1-26-13-6-10(7-14(27-2)16(13)28-3)23-18-21-8-22-19(25-18)24-15-11(20)4-5-12-17(15)30-9-29-12/h4-8H,9H2,1-3H3,(H2,21,22,23,24,25)
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n/an/a 2.96E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25204
PNG
(4,6-Pyrimidine derivative, 6 | 4-N-(5-chloro-2H-1,...)
Show SMILES COc1cc(Nc2cc(Nc3c4OCOc4ccc3Cl)ncn2)cc(OC)c1OC
Show InChI InChI=1S/C20H19ClN4O5/c1-26-14-6-11(7-15(27-2)19(14)28-3)24-16-8-17(23-9-22-16)25-18-12(21)4-5-13-20(18)30-10-29-13/h4-9H,10H2,1-3H3,(H2,22,23,24,25)
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n/an/a 2.54E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25205
PNG
(2,4-Pyrimidine derivative, 7 | 4-N-(5-chloro-2H-1,...)
Show SMILES COc1cc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)cc(OC)c1OC
Show InChI InChI=1S/C20H19ClN4O5/c1-26-14-8-11(9-15(27-2)18(14)28-3)23-20-22-7-6-16(25-20)24-17-12(21)4-5-13-19(17)30-10-29-13/h4-9H,10H2,1-3H3,(H2,22,23,24,25)
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n/an/a 240n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25206
PNG
(2,4-Pyrimidine derivative, 8 | 4-N-(5-chloro-2H-1,...)
Show SMILES Clc1ccc2OCOc2c1Nc1ccnc(Nc2ccccc2)n1
Show InChI InChI=1S/C17H13ClN4O2/c18-12-6-7-13-16(24-10-23-13)15(12)21-14-8-9-19-17(22-14)20-11-4-2-1-3-5-11/h1-9H,10H2,(H2,19,20,21,22)
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n/an/a 1.55E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25207
PNG
(2,4-Pyrimidine derivative, 9 | 4-N-(5-chloro-2H-1,...)
Show SMILES Fc1ccccc1Nc1nccc(Nc2c3OCOc3ccc2Cl)n1
Show InChI InChI=1S/C17H12ClFN4O2/c18-10-5-6-13-16(25-9-24-13)15(10)22-14-7-8-20-17(23-14)21-12-4-2-1-3-11(12)19/h1-8H,9H2,(H2,20,21,22,23)
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n/an/a 5.00E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25208
PNG
(2,4-Pyrimidine derivative, 10 | 4-N-(5-chloro-2H-1...)
Show SMILES Fc1cccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)c1
Show InChI InChI=1S/C17H12ClFN4O2/c18-12-4-5-13-16(25-9-24-13)15(12)22-14-6-7-20-17(23-14)21-11-3-1-2-10(19)8-11/h1-8H,9H2,(H2,20,21,22,23)
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n/an/a 1.15E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25209
PNG
(2,4-Pyrimidine derivative, 11 | 4-N-(5-chloro-2H-1...)
Show SMILES Fc1ccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)cc1
Show InChI InChI=1S/C17H12ClFN4O2/c18-12-5-6-13-16(25-9-24-13)15(12)22-14-7-8-20-17(23-14)21-11-3-1-10(19)2-4-11/h1-8H,9H2,(H2,20,21,22,23)
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n/an/a 2.30E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25210
PNG
(2,4-Pyrimidine derivative, 12 | 4-N-(5-chloro-2H-1...)
Show SMILES Clc1ccccc1Nc1nccc(Nc2c3OCOc3ccc2Cl)n1
Show InChI InChI=1S/C17H12Cl2N4O2/c18-10-3-1-2-4-12(10)21-17-20-8-7-14(23-17)22-15-11(19)5-6-13-16(15)25-9-24-13/h1-8H,9H2,(H2,20,21,22,23)
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n/an/a 1.13E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25211
PNG
(2,4-Pyrimidine derivative, 13 | 4-N-(5-chloro-2H-1...)
Show SMILES Clc1cccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)c1
Show InChI InChI=1S/C17H12Cl2N4O2/c18-10-2-1-3-11(8-10)21-17-20-7-6-14(23-17)22-15-12(19)4-5-13-16(15)25-9-24-13/h1-8H,9H2,(H2,20,21,22,23)
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n/an/a 1.33E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25212
PNG
(2,4-Pyrimidine derivative, 14 | 4-N-(5-chloro-2H-1...)
Show SMILES Clc1ccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)cc1
Show InChI InChI=1S/C17H12Cl2N4O2/c18-10-1-3-11(4-2-10)21-17-20-8-7-14(23-17)22-15-12(19)5-6-13-16(15)25-9-24-13/h1-8H,9H2,(H2,20,21,22,23)
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n/an/a 6.00E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25213
PNG
(2,4-Pyrimidine derivative, 15 | 4-N-(5-chloro-2H-1...)
Show SMILES Cc1ccccc1Nc1nccc(Nc2c3OCOc3ccc2Cl)n1
Show InChI InChI=1S/C18H15ClN4O2/c1-11-4-2-3-5-13(11)21-18-20-9-8-15(23-18)22-16-12(19)6-7-14-17(16)25-10-24-14/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 1.40E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25214
PNG
(2,4-Pyrimidine derivative, 16 | 4-N-(5-chloro-2H-1...)
Show SMILES Cc1cccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)c1
Show InChI InChI=1S/C18H15ClN4O2/c1-11-3-2-4-12(9-11)21-18-20-8-7-15(23-18)22-16-13(19)5-6-14-17(16)25-10-24-14/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 460n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25215
PNG
(2,4-Pyrimidine derivative, 17 | 4-N-(5-chloro-2H-1...)
Show SMILES Cc1ccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)cc1
Show InChI InChI=1S/C18H15ClN4O2/c1-11-2-4-12(5-3-11)21-18-20-9-8-15(23-18)22-16-13(19)6-7-14-17(16)25-10-24-14/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 1.60E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25216
PNG
(2,4-Pyrimidine derivative, 18 | 4-N-(5-chloro-2H-1...)
Show SMILES COc1ccccc1Nc1nccc(Nc2c3OCOc3ccc2Cl)n1
Show InChI InChI=1S/C18H15ClN4O3/c1-24-13-5-3-2-4-12(13)21-18-20-9-8-15(23-18)22-16-11(19)6-7-14-17(16)26-10-25-14/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 3.88E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25217
PNG
(2,4-Pyrimidine derivative, 19 | 4-N-(5-chloro-2H-1...)
Show SMILES COc1cccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)c1
Show InChI InChI=1S/C18H15ClN4O3/c1-24-12-4-2-3-11(9-12)21-18-20-8-7-15(23-18)22-16-13(19)5-6-14-17(16)26-10-25-14/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 640n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25218
PNG
(2,4-Pyrimidine derivative, 20 | 4-N-(5-chloro-2H-1...)
Show SMILES COc1ccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)cc1
Show InChI InChI=1S/C18H15ClN4O3/c1-24-12-4-2-11(3-5-12)21-18-20-9-8-15(23-18)22-16-13(19)6-7-14-17(16)26-10-25-14/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 1.94E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25219
PNG
(2,4-Pyrimidine derivative, 21 | 2-({4-[(5-chloro-2...)
Show SMILES Clc1ccc2OCOc2c1Nc1ccnc(Nc2ccccc2C#N)n1
Show InChI InChI=1S/C18H12ClN5O2/c19-12-5-6-14-17(26-10-25-14)16(12)23-15-7-8-21-18(24-15)22-13-4-2-1-3-11(13)9-20/h1-8H,10H2,(H2,21,22,23,24)
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n/an/a 2.05E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25220
PNG
(2,4-Pyrimidine derivative, 22 | 3-({4-[(5-chloro-2...)
Show SMILES Clc1ccc2OCOc2c1Nc1ccnc(Nc2cccc(c2)C#N)n1
Show InChI InChI=1S/C18H12ClN5O2/c19-13-4-5-14-17(26-10-25-14)16(13)23-15-6-7-21-18(24-15)22-12-3-1-2-11(8-12)9-20/h1-8H,10H2,(H2,21,22,23,24)
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n/an/a 550n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25221
PNG
(2,4-Pyrimidine derivative, 23 | 4-({4-[(5-chloro-2...)
Show SMILES Clc1ccc2OCOc2c1Nc1ccnc(Nc2ccc(cc2)C#N)n1
Show InChI InChI=1S/C18H12ClN5O2/c19-13-5-6-14-17(26-10-25-14)16(13)23-15-7-8-21-18(24-15)22-12-3-1-11(9-20)2-4-12/h1-8H,10H2,(H2,21,22,23,24)
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n/an/a 1.25E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25222
PNG
(2,4-Pyrimidine derivative, 24 | 2-({4-[(5-chloro-2...)
Show SMILES NS(=O)(=O)c1ccccc1Nc1nccc(Nc2c3OCOc3ccc2Cl)n1
Show InChI InChI=1S/C17H14ClN5O4S/c18-10-5-6-12-16(27-9-26-12)15(10)22-14-7-8-20-17(23-14)21-11-3-1-2-4-13(11)28(19,24)25/h1-8H,9H2,(H2,19,24,25)(H2,20,21,22,23)
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n/an/a 3.55E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25223
PNG
(2,4-Pyrimidine derivative, 25 | 3-({4-[(5-chloro-2...)
Show SMILES NS(=O)(=O)c1cccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)c1
Show InChI InChI=1S/C17H14ClN5O4S/c18-12-4-5-13-16(27-9-26-13)15(12)22-14-6-7-20-17(23-14)21-10-2-1-3-11(8-10)28(19,24)25/h1-8H,9H2,(H2,19,24,25)(H2,20,21,22,23)
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n/an/a 40n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25224
PNG
(2,4-Pyrimidine derivative, 26 | 4-({4-[(5-chloro-2...)
Show SMILES NS(=O)(=O)c1ccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)cc1
Show InChI InChI=1S/C17H14ClN5O4S/c18-12-5-6-13-16(27-9-26-13)15(12)22-14-7-8-20-17(23-14)21-10-1-3-11(4-2-10)28(19,24)25/h1-8H,9H2,(H2,19,24,25)(H2,20,21,22,23)
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n/an/a 300n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25225
PNG
(2,4-Pyrimidine derivative, 27 | 4-N-(5-chloro-2H-1...)
Show SMILES CS(=O)(=O)c1ccccc1Nc1nccc(Nc2c3OCOc3ccc2Cl)n1
Show InChI InChI=1S/C18H15ClN4O4S/c1-28(24,25)14-5-3-2-4-12(14)21-18-20-9-8-15(23-18)22-16-11(19)6-7-13-17(16)27-10-26-13/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 4.10E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25226
PNG
(2,4-Pyrimidine derivative, 28 | 4-N-(5-chloro-2H-1...)
Show SMILES CS(=O)(=O)c1cccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)c1
Show InChI InChI=1S/C18H15ClN4O4S/c1-28(24,25)12-4-2-3-11(9-12)21-18-20-8-7-15(23-18)22-16-13(19)5-6-14-17(16)27-10-26-14/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 90n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25227
PNG
(2,4-Pyrimidine derivative, 29 | 4-N-(5-chloro-2H-1...)
Show SMILES CS(=O)(=O)c1ccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)cc1
Show InChI InChI=1S/C18H15ClN4O4S/c1-28(24,25)12-4-2-11(3-5-12)21-18-20-9-8-15(23-18)22-16-13(19)6-7-14-17(16)27-10-26-14/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 630n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
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