BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 649 hits Enz. Inhib. hit(s) with Target = 'Epithelial discoidin domain-containing receptor 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM104010
PNG
(DDR1-IN-2)
Show SMILES CCN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(NCc3cnc4[nH]ccc4c3OC)c2)CC1
Show InChI InChI=1S/C31H35F3N6O2/c1-4-39-11-13-40(14-12-39)19-22-7-6-21(15-26(22)31(32,33)34)30(41)38-24-8-5-20(2)27(16-24)36-17-23-18-37-29-25(9-10-35-29)28(23)42-3/h5-10,15-16,18,36H,4,11-14,17,19H2,1-3H3,(H,35,37)(H,38,41)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 9n/an/an/an/a



Massachusetts General Hospital and Harvard Medical School



Assay Description
The enzyme kinase assay was carried out using the Lanthascreen technology.


ACS Chem Biol 8: 2145-50 (2013)


Article DOI: 10.1021/cb400430t
BindingDB Entry DOI: 10.7270/Q2WS8RWD
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM104009
PNG
(DDR1-IN-1)
Show SMILES CCN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(Oc3ccc4NC(=O)Cc4c3)c2)CC1
Show InChI InChI=1S/C30H31F3N4O3/c1-3-36-10-12-37(13-11-36)18-21-6-5-20(15-25(21)30(31,32)33)29(39)34-23-7-4-19(2)27(17-23)40-24-8-9-26-22(14-24)16-28(38)35-26/h4-9,14-15,17H,3,10-13,16,18H2,1-2H3,(H,34,39)(H,35,38)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/an/an/a 86n/an/an/an/a



Massachusetts General Hospital and Harvard Medical School



Assay Description
The enzyme kinase assay was carried out using the Lanthascreen technology.


ACS Chem Biol 8: 2145-50 (2013)


Article DOI: 10.1021/cb400430t
BindingDB Entry DOI: 10.7270/Q2WS8RWD
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430839
PNG
(CHEMBL2336015)
Show SMILES CCc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C30H29F3N6O/c1-3-23-6-7-25(16-24(23)5-4-21-18-34-28-8-9-35-39(28)20-21)29(40)36-27-15-22(14-26(17-27)30(31,32)33)19-38-12-10-37(2)11-13-38/h6-9,14-18,20H,3,10-13,19H2,1-2H3,(H,36,40)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 0.600n/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Binding affinity to DDR1 ATP binding site (unknown origin) after 1 hr by competitive binding assay


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430840
PNG
(CHEMBL2336017)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3cccc(c3)C#Cc3cnc4ccnn4c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C28H25F3N6O/c1-35-9-11-36(12-10-35)18-22-14-24(28(29,30)31)16-25(15-22)34-27(38)23-4-2-3-20(13-23)5-6-21-17-32-26-7-8-33-37(26)19-21/h2-4,7-8,13-17,19H,9-12,18H2,1H3,(H,34,38)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430841
PNG
(CHEMBL2336016)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc(Cl)c(c3)C#Cc3cnc4ccnn4c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C28H24ClF3N6O/c1-36-8-10-37(11-9-36)17-20-12-23(28(30,31)32)15-24(13-20)35-27(39)22-4-5-25(29)21(14-22)3-2-19-16-33-26-6-7-34-38(26)18-19/h4-7,12-16,18H,8-11,17H2,1H3,(H,35,39)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430842
PNG
(CHEMBL2336014)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cc(CN2CCCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H24F3N5O/c1-19-4-6-23(14-22(19)7-5-20-16-32-26-8-9-33-36(26)18-20)27(37)34-25-13-21(17-35-10-2-3-11-35)12-24(15-25)28(29,30)31/h4,6,8-9,12-16,18H,2-3,10-11,17H2,1H3,(H,34,37)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430843
PNG
(CHEMBL2336013)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cc(CN2CCCCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H26F3N5O/c1-20-5-7-24(15-23(20)8-6-21-17-33-27-9-10-34-37(27)19-21)28(38)35-26-14-22(13-25(16-26)29(30,31)32)18-36-11-3-2-4-12-36/h5,7,9-10,13-17,19H,2-4,11-12,18H2,1H3,(H,35,38)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 38n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430844
PNG
(CHEMBL2336012)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cc(CN2CCOCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H24F3N5O2/c1-19-2-4-23(14-22(19)5-3-20-16-32-26-6-7-33-36(26)18-20)27(37)34-25-13-21(12-24(15-25)28(29,30)31)17-35-8-10-38-11-9-35/h2,4,6-7,12-16,18H,8-11,17H2,1H3,(H,34,37)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430845
PNG
(CHEMBL2336011)
Show SMILES COc1cc(CN2CCN(C)CC2)cc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C29H30N6O2/c1-21-4-6-25(16-24(21)7-5-22-18-30-28-8-9-31-35(28)20-22)29(36)32-26-14-23(15-27(17-26)37-3)19-34-12-10-33(2)11-13-34/h4,6,8-9,14-18,20H,10-13,19H2,1-3H3,(H,32,36)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430846
PNG
(CHEMBL2336010)
Show SMILES CN1CCN(Cc2cc(Cl)cc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4ccnn4c3)c2)CC1
Show InChI InChI=1S/C28H27ClN6O/c1-20-3-5-24(15-23(20)6-4-21-17-30-27-7-8-31-35(27)19-21)28(36)32-26-14-22(13-25(29)16-26)18-34-11-9-33(2)10-12-34/h3,5,7-8,13-17,19H,9-12,18H2,1-2H3,(H,32,36)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430847
PNG
(CHEMBL2336009)
Show SMILES CN1CCN(Cc2cc(C)cc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4ccnn4c3)c2)CC1
Show InChI InChI=1S/C29H30N6O/c1-21-14-24(19-34-12-10-33(3)11-13-34)16-27(15-21)32-29(36)26-6-4-22(2)25(17-26)7-5-23-18-30-28-8-9-31-35(28)20-23/h4,6,8-9,14-18,20H,10-13,19H2,1-3H3,(H,32,36)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.70n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430848
PNG
(CHEMBL2336008)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4ccnn4c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C29H27F3N6O/c1-20-3-5-24(15-23(20)6-4-21-17-33-27-7-8-34-38(27)19-21)28(39)35-26-14-22(13-25(16-26)29(30,31)32)18-37-11-9-36(2)10-12-37/h3,5,7-8,13-17,19H,9-12,18H2,1-2H3,(H,35,39)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.90n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430849
PNG
(CHEMBL2336007)
Show SMILES Cc1cc(Cl)cc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C23H17ClN4O/c1-15-9-20(24)12-21(10-15)27-23(29)19-5-3-16(2)18(11-19)6-4-17-13-25-22-7-8-26-28(22)14-17/h3,5,7-14H,1-2H3,(H,27,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430850
PNG
(CHEMBL2336006)
Show SMILES Cc1cc(C)cc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C24H20N4O/c1-16-10-17(2)12-22(11-16)27-24(29)21-6-4-18(3)20(13-21)7-5-19-14-25-23-8-9-26-28(23)15-19/h4,6,8-15H,1-3H3,(H,27,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.30n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM13216
PNG
(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 4.80n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50237710
PNG
(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430851
PNG
(CHEMBL2336027)
Show SMILES CN1CCN(Cc2cccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4ccnn4c3)c2)CC1
Show InChI InChI=1S/C28H28N6O/c1-21-6-8-25(17-24(21)9-7-23-18-29-27-10-11-30-34(27)20-23)28(35)31-26-5-3-4-22(16-26)19-33-14-12-32(2)13-15-33/h3-6,8,10-11,16-18,20H,12-15,19H2,1-2H3,(H,31,35)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 324n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430852
PNG
(CHEMBL2336026)
Show SMILES Cc1cn(cn1)-c1cccc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C26H20N6O/c1-18-6-8-22(12-21(18)9-7-20-14-27-25-10-11-29-32(25)16-20)26(33)30-23-4-3-5-24(13-23)31-15-19(2)28-17-31/h3-6,8,10-17H,1-2H3,(H,30,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 387n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430853
PNG
(CHEMBL2336025)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cccc(c1)-n1ccnc1
Show InChI InChI=1S/C25H18N6O/c1-18-5-7-21(13-20(18)8-6-19-15-27-24-9-10-28-31(24)16-19)25(32)29-22-3-2-4-23(14-22)30-12-11-26-17-30/h2-5,7,9-17H,1H3,(H,29,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 19n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430854
PNG
(CHEMBL2336024)
Show SMILES CN(C)c1cccc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C24H21N5O/c1-17-7-9-20(24(30)27-21-5-4-6-22(14-21)28(2)3)13-19(17)10-8-18-15-25-23-11-12-26-29(23)16-18/h4-7,9,11-16H,1-3H3,(H,27,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.70n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430855
PNG
(CHEMBL2336023)
Show SMILES CC(C)Oc1cccc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C25H22N4O2/c1-17(2)31-23-6-4-5-22(14-23)28-25(30)21-9-7-18(3)20(13-21)10-8-19-15-26-24-11-12-27-29(24)16-19/h4-7,9,11-17H,1-3H3,(H,28,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 35n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430856
PNG
(CHEMBL2336022)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C23H15F3N4O/c1-15-2-4-18(22(31)29-20-8-6-19(7-9-20)23(24,25)26)12-17(15)5-3-16-13-27-21-10-11-28-30(21)14-16/h2,4,6-14H,1H3,(H,29,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430857
PNG
(CHEMBL2336021)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H15F3N4O/c1-15-5-7-18(22(31)29-20-4-2-3-19(12-20)23(24,25)26)11-17(15)8-6-16-13-27-21-9-10-28-30(21)14-16/h2-5,7,9-14H,1H3,(H,29,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.10n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430859
PNG
(CHEMBL2336020)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cccc(I)c1
Show InChI InChI=1S/C22H15IN4O/c1-15-5-7-18(22(28)26-20-4-2-3-19(23)12-20)11-17(15)8-6-16-13-24-21-9-10-25-27(21)14-16/h2-5,7,9-14H,1H3,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430860
PNG
(CHEMBL2336019)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cccc(Br)c1
Show InChI InChI=1S/C22H15BrN4O/c1-15-5-7-18(22(28)26-20-4-2-3-19(23)12-20)11-17(15)8-6-16-13-24-21-9-10-25-27(21)14-16/h2-5,7,9-14H,1H3,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430861
PNG
(CHEMBL2336018)
Show SMILES COc1ccc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)cc1
Show InChI InChI=1S/C23H18N4O2/c1-16-3-5-19(23(28)26-20-7-9-21(29-2)10-8-20)13-18(16)6-4-17-14-24-22-11-12-25-27(22)15-17/h3,5,7-15H,1-2H3,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430862
PNG
(CHEMBL2336040)
Show SMILES COc1cccc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C23H18N4O2/c1-16-6-8-19(23(28)26-20-4-3-5-21(13-20)29-2)12-18(16)9-7-17-14-24-22-10-11-25-27(22)15-17/h3-6,8,10-15H,1-2H3,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430863
PNG
(CHEMBL2336039)
Show SMILES COc1ccccc1NC(=O)c1ccc(C)c(c1)C#Cc1cnc2ccnn2c1
Show InChI InChI=1S/C23H18N4O2/c1-16-7-9-19(23(28)26-20-5-3-4-6-21(20)29-2)13-18(16)10-8-17-14-24-22-11-12-25-27(22)15-17/h3-7,9,11-15H,1-2H3,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 470n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430864
PNG
(CHEMBL2336038)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C22H15ClN4O/c1-15-2-4-18(22(28)26-20-8-6-19(23)7-9-20)12-17(15)5-3-16-13-24-21-10-11-25-27(21)14-16/h2,4,6-14H,1H3,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430865
PNG
(CHEMBL2336037)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C22H15ClN4O/c1-15-5-7-18(22(28)26-20-4-2-3-19(23)12-20)11-17(15)8-6-16-13-24-21-9-10-25-27(21)14-16/h2-5,7,9-14H,1H3,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.30n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430866
PNG
(CHEMBL2336036)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C22H15ClN4O/c1-15-6-8-18(22(28)26-20-5-3-2-4-19(20)23)12-17(15)9-7-16-13-24-21-10-11-25-27(21)14-16/h2-6,8,10-14H,1H3,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430867
PNG
(CHEMBL2336035)
Show SMILES Cc1ccc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)cc1
Show InChI InChI=1S/C23H18N4O/c1-16-3-9-21(10-4-16)26-23(28)20-7-5-17(2)19(13-20)8-6-18-14-24-22-11-12-25-27(22)15-18/h3-5,7,9-15H,1-2H3,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 48n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430868
PNG
(CHEMBL2331602)
Show SMILES Cc1cccc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C23H18N4O/c1-16-4-3-5-21(12-16)26-23(28)20-8-6-17(2)19(13-20)9-7-18-14-24-22-10-11-25-27(22)15-18/h3-6,8,10-15H,1-2H3,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430869
PNG
(CHEMBL2336034)
Show SMILES Cc1ccccc1NC(=O)c1ccc(C)c(c1)C#Cc1cnc2ccnn2c1
Show InChI InChI=1S/C23H18N4O/c1-16-7-9-20(23(28)26-21-6-4-3-5-17(21)2)13-19(16)10-8-18-14-24-22-11-12-25-27(22)15-18/h3-7,9,11-15H,1-2H3,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430870
PNG
(CHEMBL2336033)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C22H16N4O/c1-16-7-9-19(22(27)25-20-5-3-2-4-6-20)13-18(16)10-8-17-14-23-21-11-12-24-26(21)15-17/h2-7,9,11-15H,1H3,(H,25,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 39n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430871
PNG
(CHEMBL2336032)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)NC1CCCC1
Show InChI InChI=1S/C21H20N4O/c1-15-6-8-18(21(26)24-19-4-2-3-5-19)12-17(15)9-7-16-13-22-20-10-11-23-25(20)14-16/h6,8,10-14,19H,2-5H2,1H3,(H,24,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430872
PNG
(CHEMBL2336031)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)NC1CCCCC1
Show InChI InChI=1S/C22H22N4O/c1-16-7-9-19(22(27)25-20-5-3-2-4-6-20)13-18(16)10-8-17-14-23-21-11-12-24-26(21)15-17/h7,9,11-15,20H,2-6H2,1H3,(H,25,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430873
PNG
(CHEMBL2336030)
Show SMILES CC(C)CNC(=O)c1ccc(C)c(c1)C#Cc1cnc2ccnn2c1
Show InChI InChI=1S/C20H20N4O/c1-14(2)11-22-20(25)18-6-4-15(3)17(10-18)7-5-16-12-21-19-8-9-23-24(19)13-16/h4,6,8-10,12-14H,11H2,1-3H3,(H,22,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430874
PNG
(CHEMBL2336029)
Show SMILES CCCCNC(=O)c1ccc(C)c(c1)C#Cc1cnc2ccnn2c1
Show InChI InChI=1S/C20H20N4O/c1-3-4-10-21-20(25)18-7-5-15(2)17(12-18)8-6-16-13-22-19-9-11-23-24(19)14-16/h5,7,9,11-14H,3-4,10H2,1-2H3,(H,21,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 65n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430858
PNG
(CHEMBL2336028)
Show SMILES CC(C)NC(=O)c1ccc(C)c(c1)C#Cc1cnc2ccnn2c1
Show InChI InChI=1S/C19H18N4O/c1-13(2)22-19(24)17-6-4-14(3)16(10-17)7-5-15-11-20-18-8-9-21-23(18)12-15/h4,6,8-13H,1-3H3,(H,22,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430875
PNG
(CHEMBL2336005 | US9062066, LCB 03-0110)
Show SMILES Oc1cccc(Nc2ccnc3cc(sc23)-c2cccc(CN3CCOCC3)c2)c1
Show InChI InChI=1S/C24H23N3O2S/c28-20-6-2-5-19(14-20)26-21-7-8-25-22-15-23(30-24(21)22)18-4-1-3-17(13-18)16-27-9-11-29-12-10-27/h1-8,13-15,28H,9-12,16H2,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 164n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of type 1 collagen-induced autophosphorylation of human recombinant DDR1 expressed in HEK293 cells by Western blotting analysis


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

PCBioAssay
n/an/an/a 5.80E+4n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM24773
PNG
(AMG 706 | AMG-706 | Motesanib | N-(3,3-dimethyl-1,...)
Show SMILES CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12
Show InChI InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PCBioAssay
n/an/an/a 2.60E+5n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM31085
PNG
(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)
Show SMILES CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

PCBioAssay
n/an/an/a 690n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM26300
PNG
(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}qu...)
Show SMILES CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1
Show InChI InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PCBioAssay
n/an/an/a 1.80E+6n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM13533
PNG
(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PCBioAssay
n/an/an/a 1.90E+3n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM25118
PNG
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O
Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

PCBioAssay
n/an/an/a 2.50E+6n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM31088
PNG
(1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-y...)
Show SMILES Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12
Show InChI InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Patents


Similars

PCBioAssay
n/an/an/a 1.30E+4n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM4779
PNG
(CHEMBL31965 | CHEMBL545315 | CI-1033 | N-{4-[(3-ch...)
Show SMILES Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl
Show InChI InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

PCBioAssay
n/an/an/a 4.00E+5n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM13216
PNG
(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
PCBioAssay
n/an/an/a 690n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Displayed 1 to 50 (of 649 total )  |  Next  |  Last  >>
Jump to: