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Compile Data Set for Download or QSAR

Found 2125 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM6190
PNG
(3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6...)
Show SMILES CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
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n/an/an/an/a 21n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50242740
PNG
(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)
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n/an/an/an/a 80n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM25118
PNG
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O
Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)
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n/an/an/an/a 166n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 phosphorylation expressed in human KM12L4A cells by Western blot analysis


J Med Chem 52: 278-92 (2009)


Article DOI: 10.1021/jm800790t
BindingDB Entry DOI: 10.7270/Q2TD9X7X
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50242742
PNG
(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50073587
PNG
(CHEMBL3408947)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1
Show InChI InChI=1S/C33H34N4O3/c1-20-17-37(18-21(2)40-20)19-23-6-4-22(5-7-23)8-12-29-26-11-9-24(14-31(26)36-35-29)28-16-33(28)27-15-25(39-3)10-13-30(27)34-32(33)38/h4-15,20-21,28H,16-19H2,1-3H3,(H,34,38)(H,35,36)/b12-8+/t20-,21+,28-,33-/m0/s1
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n/an/an/an/a 1.10E+3n/an/an/an/a



Zhengzhou University

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 (unknown origin)


Eur J Med Chem 95: 35-40 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.020
BindingDB Entry DOI: 10.7270/Q2NG4SBV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3443
PNG
(1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyr...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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45.2n/an/an/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 286: 569-77 (1998)


BindingDB Entry DOI: 10.7270/Q2C24TZQ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50206819
PNG
(CHEMBL3893914)
Show SMILES Cc1cc(Nc2cc(C)c(C#N)c(NCCOc3ccc(C)nc3)n2)n[nH]1
Show InChI InChI=1S/C19H21N7O/c1-12-8-17(23-18-9-14(3)25-26-18)24-19(16(12)10-20)21-6-7-27-15-5-4-13(2)22-11-15/h4-5,8-9,11H,6-7H2,1-3H3,(H3,21,23,24,25,26)
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80n/an/an/an/an/an/an/an/a



CXS Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 (unknown origin)


Bioorg Med Chem Lett 26: 5860-5862 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.020
BindingDB Entry DOI: 10.7270/Q2WS8W80
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50020310
PNG
(CHEMBL3288854)
Show SMILES CN1CCN(CCC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c2C)CC1
Show InChI InChI=1S/C23H28FN5O2/c1-14-20(13-18-17-12-16(24)4-5-19(17)26-23(18)31)25-15(2)22(14)27-21(30)6-7-29-10-8-28(3)9-11-29/h4-5,12-13,25H,6-11H2,1-3H3,(H,26,31)(H,27,30)/b18-13-
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350n/an/an/an/an/an/an/an/a



Qilu Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Binding affinity to FGFR1 (unknown origin)


Eur J Med Chem 82: 139-51 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.051
BindingDB Entry DOI: 10.7270/Q2F1918D
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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>4.74E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FGFR


Bioorg Med Chem Lett 17: 6593-601 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50237710
PNG
(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
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8.02E+3n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 103: 3153-8 (2006)


Article DOI: 10.1073/pnas.0511292103
BindingDB Entry DOI: 10.7270/Q21Z430B
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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>1.00E+4n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 103: 3153-8 (2006)


Article DOI: 10.1073/pnas.0511292103
BindingDB Entry DOI: 10.7270/Q21Z430B
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50431812
PNG
(CHEMBL2347053)
Show SMILES [O-][N+](=O)c1ccccc1-c1n[nH]cc1C=C1C(=O)Nc2ccccc12
Show InChI InChI=1S/C18H12N4O3/c23-18-14(12-5-1-3-7-15(12)20-18)9-11-10-19-21-17(11)13-6-2-4-8-16(13)22(24)25/h1-10H,(H,19,21)(H,20,23)
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n/an/a 12n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 (unknown origin) after 10 mins by mobility shift assay


Bioorg Med Chem 21: 1724-34 (2013)


Article DOI: 10.1016/j.bmc.2013.01.047
BindingDB Entry DOI: 10.7270/Q2GQ704N
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3050
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-...)
Show SMILES Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C14H10Cl2N4O/c1-20-12-7(6-18-14(17)19-12)5-8(13(20)21)11-9(15)3-2-4-10(11)16/h2-6H,1H3,(H2,17,18,19)
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n/an/a 1.30E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3051
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 5 | N-[6-(...)
Show SMILES CC(=O)Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C16H12Cl2N4O2/c1-8(23)20-16-19-7-9-6-10(15(24)22(2)14(9)21-16)13-11(17)4-3-5-12(13)18/h3-7H,1-2H3,(H,19,20,21,23)
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n/an/a 5.80E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3052
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 19 | 6-(2,...)
Show SMILES Cc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C15H11Cl2N3O/c1-8-18-7-9-6-10(15(21)20(2)14(9)19-8)13-11(16)4-3-5-12(13)17/h3-7H,1-2H3
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n/an/a>5.00E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3053
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 20 | 6-(2,...)
Show SMILES Cn1c2nc(=O)[nH]cc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C14H9Cl2N3O2/c1-19-12-7(6-17-14(21)18-12)5-8(13(19)20)11-9(15)3-2-4-10(11)16/h2-6H,1H3,(H,17,18,21)
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n/an/a>5.00E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3054
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 21 | 6-(2,...)
Show SMILES CNc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C15H12Cl2N4O/c1-18-15-19-7-8-6-9(14(22)21(2)13(8)20-15)12-10(16)4-3-5-11(12)17/h3-7H,1-2H3,(H,18,19,20)
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n/an/a 2.50E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3055
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 22 | 6-(2,...)
Show SMILES CCNc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C16H14Cl2N4O/c1-3-19-16-20-8-9-7-10(15(23)22(2)14(9)21-16)13-11(17)5-4-6-12(13)18/h4-8H,3H2,1-2H3,(H,19,20,21)
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n/an/a 960n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3056
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 23 | 6-(2,...)
Show SMILES CC(C)Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C17H16Cl2N4O/c1-9(2)21-17-20-8-10-7-11(16(24)23(3)15(10)22-17)14-12(18)5-4-6-13(14)19/h4-9H,1-3H3,(H,20,21,22)
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n/an/a 700n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3057
PNG
(2-(butylamino)-6-(2,6-dichlorophenyl)-8-methyl-7H,...)
Show SMILES CCCCNc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C18H18Cl2N4O/c1-3-4-8-21-18-22-10-11-9-12(17(25)24(2)16(11)23-18)15-13(19)6-5-7-14(15)20/h5-7,9-10H,3-4,8H2,1-2H3,(H,21,22,23)
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n/an/a 4.48E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3076
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 43 | 6-(2,...)
Show SMILES CCn1c2nc(Nc3ccncc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C20H15Cl2N5O/c1-2-27-18-12(11-24-20(26-18)25-13-6-8-23-9-7-13)10-14(19(27)28)17-15(21)4-3-5-16(17)22/h3-11H,2H2,1H3,(H,23,24,25,26)
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n/an/a 110n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3077
PNG
(2-[(4-chlorophenyl)amino]-6-(2,6-dichlorophenyl)-8...)
Show SMILES Cn1c2nc(Nc3ccc(Cl)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C20H13Cl3N4O/c1-27-18-11(9-14(19(27)28)17-15(22)3-2-4-16(17)23)10-24-20(26-18)25-13-7-5-12(21)6-8-13/h2-10H,1H3,(H,24,25,26)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3078
PNG
(2-[(3-bromophenyl)amino]-6-(2,6-dichlorophenyl)-8-...)
Show SMILES Cn1c2nc(Nc3cccc(Br)c3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C20H13BrCl2N4O/c1-27-18-11(8-14(19(27)28)17-15(22)6-3-7-16(17)23)10-24-20(26-18)25-13-5-2-4-12(21)9-13/h2-10H,1H3,(H,24,25,26)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3079
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 46 | 6-(2,...)
Show SMILES Cc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1
Show InChI InChI=1S/C21H16Cl2N4O/c1-12-6-8-14(9-7-12)25-21-24-11-13-10-15(20(28)27(2)19(13)26-21)18-16(22)4-3-5-17(18)23/h3-11H,1-2H3,(H,24,25,26)
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n/an/a 910n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3080
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 47 | 6-(2,...)
Show SMILES COc1ccccc1Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C21H16Cl2N4O2/c1-27-19-12(10-13(20(27)28)18-14(22)6-5-7-15(18)23)11-24-21(26-19)25-16-8-3-4-9-17(16)29-2/h3-11H,1-2H3,(H,24,25,26)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3081
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 48 | 6-(2,...)
Show SMILES COc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1
Show InChI InChI=1S/C21H16Cl2N4O2/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26)
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n/an/a 370n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3082
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 49 | 6-(2,...)
Show SMILES COc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1
Show InChI InChI=1S/C21H16Cl2N4O2/c1-27-19-12(10-15(20(27)28)18-16(22)4-3-5-17(18)23)11-24-21(26-19)25-13-6-8-14(29-2)9-7-13/h3-11H,1-2H3,(H,24,25,26)
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n/an/a 410n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3083
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 50 | 6-(2,...)
Show SMILES Cn1c2nc(Nc3cccc(O)c3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C20H14Cl2N4O2/c1-26-18-11(8-14(19(26)28)17-15(21)6-3-7-16(17)22)10-23-20(25-18)24-12-4-2-5-13(27)9-12/h2-10,27H,1H3,(H,23,24,25)
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n/an/a 180n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3084
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 51 | 6-(2,...)
Show SMILES Cn1c2nc(Nc3ccc(O)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C20H14Cl2N4O2/c1-26-18-11(9-14(19(26)28)17-15(21)3-2-4-16(17)22)10-23-20(25-18)24-12-5-7-13(27)8-6-12/h2-10,27H,1H3,(H,23,24,25)
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n/an/a 150n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3085
PNG
(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Show SMILES Cn1c2nc(Nc3cccc(CO)c3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C21H16Cl2N4O2/c1-27-19-13(9-15(20(27)29)18-16(22)6-3-7-17(18)23)10-24-21(26-19)25-14-5-2-4-12(8-14)11-28/h2-10,28H,11H2,1H3,(H,24,25,26)
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n/an/a 80n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3086
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 53 | 6-(2,...)
Show SMILES COc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1C
Show InChI InChI=1S/C22H18Cl2N4O2/c1-12-9-14(7-8-18(12)30-3)26-22-25-11-13-10-15(21(29)28(2)20(13)27-22)19-16(23)5-4-6-17(19)24/h4-11H,1-3H3,(H,25,26,27)
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n/an/a 450n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3087
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 54 | 6-(2,...)
Show SMILES COc1cc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc(OC)c1
Show InChI InChI=1S/C22H18Cl2N4O3/c1-28-20-12(7-16(21(28)29)19-17(23)5-4-6-18(19)24)11-25-22(27-20)26-13-8-14(30-2)10-15(9-13)31-3/h4-11H,1-3H3,(H,25,26,27)
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n/an/a 430n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3088
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 55 | PD 16...)
Show SMILES CCOC(=O)c1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1
Show InChI InChI=1S/C23H18Cl2N4O3/c1-3-32-22(31)13-6-4-7-15(10-13)27-23-26-12-14-11-16(21(30)29(2)20(14)28-23)19-17(24)8-5-9-18(19)25/h4-12H,3H2,1-2H3,(H,26,27,28)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3089
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 56 | PD 16...)
Show SMILES CCOC(=O)c1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1
Show InChI InChI=1S/C23H18Cl2N4O3/c1-3-32-22(31)13-7-9-15(10-8-13)27-23-26-12-14-11-16(21(30)29(2)20(14)28-23)19-17(24)5-4-6-18(19)25/h4-12H,3H2,1-2H3,(H,26,27,28)
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n/an/a 3.36E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3058
PNG
(2-(cyclohexylamino)-6-(2,6-dichlorophenyl)-8-methy...)
Show SMILES Cn1c2nc(NC3CCCCC3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C20H20Cl2N4O/c1-26-18-12(11-23-20(25-18)24-13-6-3-2-4-7-13)10-14(19(26)27)17-15(21)8-5-9-16(17)22/h5,8-11,13H,2-4,6-7H2,1H3,(H,23,24,25)
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n/an/a 6.80E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3059
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 26 | 6-(2,...)
Show SMILES Cn1c2nc(NCCO)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C16H14Cl2N4O2/c1-22-14-9(8-20-16(21-14)19-5-6-23)7-10(15(22)24)13-11(17)3-2-4-12(13)18/h2-4,7-8,23H,5-6H2,1H3,(H,19,20,21)
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n/an/a 1.66E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3060
PNG
(2-(benzylamino)-6-(2,6-dichlorophenyl)-8-methyl-7H...)
Show SMILES Cn1c2nc(NCc3ccccc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C21H16Cl2N4O/c1-27-19-14(10-15(20(27)28)18-16(22)8-5-9-17(18)23)12-25-21(26-19)24-11-13-6-3-2-4-7-13/h2-10,12H,11H2,1H3,(H,24,25,26)
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n/an/a 1.40E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3061
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 28 | 6-(2,...)
Show SMILES CN(C)c1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C16H14Cl2N4O/c1-21(2)16-19-8-9-7-10(15(23)22(3)14(9)20-16)13-11(17)5-4-6-12(13)18/h4-8H,1-3H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3062
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 29 | 6-(2,...)
Show SMILES CCN(CC)CCCNc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C21H25Cl2N5O/c1-4-28(5-2)11-7-10-24-21-25-13-14-12-15(20(29)27(3)19(14)26-21)18-16(22)8-6-9-17(18)23/h6,8-9,12-13H,4-5,7,10-11H2,1-3H3,(H,24,25,26)
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n/an/a 1.39E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3063
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 30 | 6-(2,...)
Show SMILES Cn1c2nc(NCCCN3CCOCC3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C21H23Cl2N5O2/c1-27-19-14(12-15(20(27)29)18-16(22)4-2-5-17(18)23)13-25-21(26-19)24-6-3-7-28-8-10-30-11-9-28/h2,4-5,12-13H,3,6-11H2,1H3,(H,24,25,26)
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n/an/a 1.41E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3064
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 31 | 6-(2,...)
Show SMILES CN1CCN(CCCNc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)CC1
Show InChI InChI=1S/C22H26Cl2N6O/c1-28-9-11-30(12-10-28)8-4-7-25-22-26-14-15-13-16(21(31)29(2)20(15)27-22)19-17(23)5-3-6-18(19)24/h3,5-6,13-14H,4,7-12H2,1-2H3,(H,25,26,27)
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n/an/a 380n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3065
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 32 | 6-(2,...)
Show SMILES CN1CCN(CCCCNc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)CC1
Show InChI InChI=1S/C23H28Cl2N6O/c1-29-10-12-31(13-11-29)9-4-3-8-26-23-27-15-16-14-17(22(32)30(2)21(16)28-23)20-18(24)6-5-7-19(20)25/h5-7,14-15H,3-4,8-13H2,1-2H3,(H,26,27,28)
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n/an/a 320n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3066
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 33 | 6-(2,...)
Show SMILES CN1CCN(CCCCCNc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)CC1
Show InChI InChI=1S/C24H30Cl2N6O/c1-30-11-13-32(14-12-30)10-5-3-4-9-27-24-28-16-17-15-18(23(33)31(2)22(17)29-24)21-19(25)7-6-8-20(21)26/h6-8,15-16H,3-5,9-14H2,1-2H3,(H,27,28,29)
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n/an/a 240n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3067
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 34 | 6-(2,...)
Show SMILES Cn1c2nc(NCc3ccccn3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C20H15Cl2N5O/c1-27-18-12(9-14(19(27)28)17-15(21)6-4-7-16(17)22)10-24-20(26-18)25-11-13-5-2-3-8-23-13/h2-10H,11H2,1H3,(H,24,25,26)
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n/an/a 3.21E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3068
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 35 | 6-(2,...)
Show SMILES Cn1c2nc(NCc3cccnc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C20H15Cl2N5O/c1-27-18-13(8-14(19(27)28)17-15(21)5-2-6-16(17)22)11-25-20(26-18)24-10-12-4-3-7-23-9-12/h2-9,11H,10H2,1H3,(H,24,25,26)
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n/an/a 3.15E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3069
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 36 | 6-(2,...)
Show SMILES Cn1c2nc(NCCc3ccccn3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C21H17Cl2N5O/c1-28-19-13(11-15(20(28)29)18-16(22)6-4-7-17(18)23)12-26-21(27-19)25-10-8-14-5-2-3-9-24-14/h2-7,9,11-12H,8,10H2,1H3,(H,25,26,27)
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n/an/a 6.53E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3070
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 37 | 6-[6-...)
Show SMILES Cn1c2nc(NCCCCCC(O)=O)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C20H20Cl2N4O3/c1-26-18-12(10-13(19(26)29)17-14(21)6-5-7-15(17)22)11-24-20(25-18)23-9-4-2-3-8-16(27)28/h5-7,10-11H,2-4,8-9H2,1H3,(H,27,28)(H,23,24,25)
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n/an/a 580n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3071
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 38 | 2-ani...)
Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C20H14Cl2N4O/c1-26-18-12(11-23-20(25-18)24-13-6-3-2-4-7-13)10-14(19(26)27)17-15(21)8-5-9-16(17)22/h2-11H,1H3,(H,23,24,25)
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n/an/a 460n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3072
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 39 | 6-(2,...)
Show SMILES CCn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C21H16Cl2N4O/c1-2-27-19-13(12-24-21(26-19)25-14-7-4-3-5-8-14)11-15(20(27)28)18-16(22)9-6-10-17(18)23/h3-12H,2H2,1H3,(H,24,25,26)
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n/an/a 210n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3073
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 40 | 6-(2,...)
Show SMILES Cn1c2nc(Nc3cccnc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C19H13Cl2N5O/c1-26-17-11(9-23-19(25-17)24-12-4-3-7-22-10-12)8-13(18(26)27)16-14(20)5-2-6-15(16)21/h2-10H,1H3,(H,23,24,25)
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n/an/a 150n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
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