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Compile Data Set for Download or QSAR

Found 1022 hits Enz. Inhib. hit(s) with Target = 'Formyl peptide receptor 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377270
PNG
(US10265310, Example 16 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)C1CCOCC1
Show InChI InChI=1/C25H30ClN3O4/c1-32-21-8-2-17(3-9-21)22-10-13-29(24(30)18-11-14-33-15-12-18)16-23(22)28-25(31)27-20-6-4-19(26)5-7-20/h2-9,18,22-23H,10-16H2,1H3,(H2,27,28,31)/t22-,23+/s2
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377268
PNG
(US10265310, Example 14 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)C(C)(F)F
Show InChI InChI=1/C22H24ClF2N3O3/c1-22(24,25)20(29)28-12-11-18(14-3-9-17(31-2)10-4-14)19(13-28)27-21(30)26-16-7-5-15(23)6-8-16/h3-10,18-19H,11-13H2,1-2H3,(H2,26,27,30)/t18-,19+/s2
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377271
PNG
(US10265310, Example 17 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)C(C)C
Show InChI InChI=1/C23H28ClN3O3/c1-15(2)22(28)27-13-12-20(16-4-10-19(30-3)11-5-16)21(14-27)26-23(29)25-18-8-6-17(24)7-9-18/h4-11,15,20-21H,12-14H2,1-3H3,(H2,25,26,29)/t20-,21+/s2
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377272
PNG
(US10265310, Example 18 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)CC(C)C
Show InChI InChI=1/C24H30ClN3O3/c1-16(2)14-23(29)28-13-12-21(17-4-10-20(31-3)11-5-17)22(15-28)27-24(30)26-19-8-6-18(25)7-9-19/h4-11,16,21-22H,12-15H2,1-3H3,(H2,26,27,30)/t21-,22+/s2
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377275
PNG
(US10265310, Example 21 | rac-trans-methyl 2-(5-(3-...)
Show SMILES COC(=O)CN1C[C@H](NC(=O)Nc2ccc(Cl)cc2)[C@H](CC1=O)c1ccc(OC)cc1
Show InChI InChI=1S/C22H24ClN3O5/c1-30-17-9-3-14(4-10-17)18-11-20(27)26(13-21(28)31-2)12-19(18)25-22(29)24-16-7-5-15(23)6-8-16/h3-10,18-19H,11-13H2,1-2H3,(H2,24,25,29)/t18-,19+/m1/s1
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377283
PNG
(US10265310, Example 30 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)CCO
Show InChI InChI=1/C22H26ClN3O4/c1-30-18-8-2-15(3-9-18)19-10-12-26(21(28)11-13-27)14-20(19)25-22(29)24-17-6-4-16(23)5-7-17/h2-9,19-20,27H,10-14H2,1H3,(H2,24,25,29)/t19-,20+/s2
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377308
PNG
(US10265310, Example 61 | US10265310, Example 62 | ...)
Show SMILES COc1ccc(C2CC(=O)N(CC(F)F)CC2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C21H21ClF3N3O3/c1-31-14-6-7-15(17(23)8-14)16-9-20(29)28(11-19(24)25)10-18(16)27-21(30)26-13-4-2-12(22)3-5-13/h2-8,16,18-19H,9-11H2,1H3,(H2,26,27,30)
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377328
PNG
(US10265310, Example 86 | trans-ent1-1-(4-chlorophe...)
Show SMILES COc1ccc([C@H]2CCN(C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)C(=O)C2CC2)c(F)c1
Show InChI InChI=1S/C23H25ClFN3O3/c1-31-17-8-9-18(20(25)12-17)19-10-11-28(22(29)14-2-3-14)13-21(19)27-23(30)26-16-6-4-15(24)5-7-16/h4-9,12,14,19,21H,2-3,10-11,13H2,1H3,(H2,26,27,30)/t19-,21+/m1/s1
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377269
PNG
(US10265310, Example 15 | rac-trans-1-(4-chlorophen...)
Show SMILES COCCC(=O)N1CC[C@@H]([C@H](C1)NC(=O)Nc1ccc(Cl)cc1)c1ccc(OC)cc1
Show InChI InChI=1/C23H28ClN3O4/c1-30-14-12-22(28)27-13-11-20(16-3-9-19(31-2)10-4-16)21(15-27)26-23(29)25-18-7-5-17(24)6-8-18/h3-10,20-21H,11-15H2,1-2H3,(H2,25,26,29)/t20-,21+/s2
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377267
PNG
(US10265310, Example 13 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)CO
Show InChI InChI=1/C21H24ClN3O4/c1-29-17-8-2-14(3-9-17)18-10-11-25(20(27)13-26)12-19(18)24-21(28)23-16-6-4-15(22)5-7-16/h2-9,18-19,26H,10-13H2,1H3,(H2,23,24,28)/t18-,19+/s2
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377266
PNG
(US10265310, Example 12 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)C1CC1
Show InChI InChI=1/C23H26ClN3O3/c1-30-19-10-4-15(5-11-19)20-12-13-27(22(28)16-2-3-16)14-21(20)26-23(29)25-18-8-6-17(24)7-9-18/h4-11,16,20-21H,2-3,12-14H2,1H3,(H2,25,26,29)/t20-,21+/s2
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377264
PNG
(US10265310, Example 10 | trans-ent1-(4-chloropheny...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)N(C)C[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C20H22ClN3O3/c1-24-12-18(23-20(26)22-15-7-5-14(21)6-8-15)17(11-19(24)25)13-3-9-16(27-2)10-4-13/h3-10,17-18H,11-12H2,1-2H3,(H2,22,23,26)/t17-,18+/m1/s1
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377261
PNG
(US10265310, Example 7 | rac-trans-1-(4-chloropheny...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)N(C)C[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C20H22ClN3O3/c1-24-12-18(23-20(26)22-15-7-5-14(21)6-8-15)17(11-19(24)25)13-3-9-16(27-2)10-4-13/h3-10,17-18H,11-12H2,1-2H3,(H2,22,23,26)/t17-,18+/s2
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377256
PNG
(US10265310, Example 2 | rac-trans-1-(1-acetyl-4-(4...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1/C21H24ClN3O3/c1-14(26)25-12-11-19(15-3-9-18(28-2)10-4-15)20(13-25)24-21(27)23-17-7-5-16(22)6-8-17/h3-10,19-20H,11-13H2,1-2H3,(H2,23,24,27)/t19-,20+/s2
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50050929
PNG
(2-((S)-2-{(S)-2-[3-(4-Methoxy-phenyl)-ureido]-4-me...)
Show SMILES COc1ccc(NC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2ccccc2)C(O)=O)cc1
Show InChI InChI=1S/C28H38N4O6S/c1-18(2)16-23(26(34)31-24(27(35)36)17-19-8-6-5-7-9-19)30-25(33)22(14-15-39-4)32-28(37)29-20-10-12-21(38-3)13-11-20/h5-13,18,22-24H,14-17H2,1-4H3,(H,30,33)(H,31,34)(H,35,36)(H2,29,32,37)/t22-,23-,24?/m0/s1
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n/an/an/an/a 1n/an/an/an/a



Johnson Matthey Biomedical Research

Curated by ChEMBL


Assay Description
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neut...


J Med Chem 39: 1013-5 (1996)


Article DOI: 10.1021/jm950908d
BindingDB Entry DOI: 10.7270/Q2TD9WF6
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50050933
PNG
((S)-2-((S)-2-{(S)-2-[3-(4-Chloro-phenyl)-ureido]-4...)
Show SMILES CSCC[C@H](NC(=O)Nc1ccc(Cl)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C27H35ClN4O5S/c1-17(2)15-22(25(34)31-23(26(35)36)16-18-7-5-4-6-8-18)30-24(33)21(13-14-38-3)32-27(37)29-20-11-9-19(28)10-12-20/h4-12,17,21-23H,13-16H2,1-3H3,(H,30,33)(H,31,34)(H,35,36)(H2,29,32,37)/t21-,22-,23-/m0/s1
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n/an/an/an/a 1n/an/an/an/a



Johnson Matthey Biomedical Research

Curated by ChEMBL


Assay Description
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neut...


J Med Chem 39: 1013-5 (1996)


Article DOI: 10.1021/jm950908d
BindingDB Entry DOI: 10.7270/Q2TD9WF6
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50050935
PNG
((S)-2-{(S)-4-Methyl-2-[(S)-4-methylsulfanyl-2-(3-p...)
Show SMILES CSCC[C@H](NC(=O)Nc1ccc(C)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C28H38N4O5S/c1-18(2)16-23(26(34)31-24(27(35)36)17-20-8-6-5-7-9-20)30-25(33)22(14-15-38-4)32-28(37)29-21-12-10-19(3)11-13-21/h5-13,18,22-24H,14-17H2,1-4H3,(H,30,33)(H,31,34)(H,35,36)(H2,29,32,37)/t22-,23-,24-/m0/s1
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n/an/an/an/a 2n/an/an/an/a



Johnson Matthey Biomedical Research

Curated by ChEMBL


Assay Description
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neut...


J Med Chem 39: 1013-5 (1996)


Article DOI: 10.1021/jm950908d
BindingDB Entry DOI: 10.7270/Q2TD9WF6
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295526
PNG
(CHEMBL564392 | N-(4-Bromophenyl)-2-[5-(3-methoxybe...)
Show SMILES COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1
Show InChI InChI=1/C22H22BrN3O3/c1-14-11-17(12-16-5-4-6-20(13-16)29-3)22(28)26(25-14)15(2)21(27)24-19-9-7-18(23)8-10-19/h4-11,13,15H,12H2,1-3H3,(H,24,27)
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n/an/an/an/a 8n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles by chemotaxis assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50050937
PNG
((S)-2-[(S)-2-((S)-2-Formylamino-4-methylsulfanyl-b...)
Show SMILES CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
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n/an/an/an/a 10n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295518
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1
Show InChI InChI=1S/C22H23N3O4/c1-15-11-17(12-16-5-4-6-20(13-16)29-3)22(27)25(24-15)14-21(26)23-18-7-9-19(28-2)10-8-18/h4-11,13H,12,14H2,1-3H3,(H,23,26)
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n/an/an/an/a 11n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles by chemotaxis assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295517
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1
Show InChI InChI=1S/C22H23N3O3/c1-15-7-9-19(10-8-15)23-21(26)14-25-22(27)18(11-16(2)24-25)12-17-5-4-6-20(13-17)28-3/h4-11,13H,12,14H2,1-3H3,(H,23,26)
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n/an/an/an/a 16n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles by chemotaxis assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295517
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1
Show InChI InChI=1S/C22H23N3O3/c1-15-7-9-19(10-8-15)23-21(26)14-25-22(27)18(11-16(2)24-25)12-17-5-4-6-20(13-17)28-3/h4-11,13H,12,14H2,1-3H3,(H,23,26)
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n/an/an/an/a 16n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50050937
PNG
((S)-2-[(S)-2-((S)-2-Formylamino-4-methylsulfanyl-b...)
Show SMILES CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
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n/an/an/an/a 20n/an/an/an/a



Johnson Matthey Biomedical Research

Curated by ChEMBL


Assay Description
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neut...


J Med Chem 39: 1013-5 (1996)


Article DOI: 10.1021/jm950908d
BindingDB Entry DOI: 10.7270/Q2TD9WF6
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295524
PNG
(CHEMBL551589 | N-(4-Bromophenyl)-2-[5-(3-methoxybe...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1
Show InChI InChI=1S/C21H20BrN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 26n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295514
PNG
(CHEMBL556625 | N-(4-Chlorophenyl)-2-[5-(3-methoxyb...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 26n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295515
PNG
(CHEMBL560780 | N-(4-Iodophenyl)-2-[5-(3-methoxyben...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1
Show InChI InChI=1S/C21H20IN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 28n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295515
PNG
(CHEMBL560780 | N-(4-Iodophenyl)-2-[5-(3-methoxyben...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1
Show InChI InChI=1S/C21H20IN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 32n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295527
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1
Show InChI InChI=1S/C21H21N3O3/c1-15-11-17(12-16-7-6-10-19(13-16)27-2)21(26)24(23-15)14-20(25)22-18-8-4-3-5-9-18/h3-11,13H,12,14H2,1-2H3,(H,22,25)
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n/an/an/an/a 32n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles by chemotaxis assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295526
PNG
(CHEMBL564392 | N-(4-Bromophenyl)-2-[5-(3-methoxybe...)
Show SMILES COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1
Show InChI InChI=1/C22H22BrN3O3/c1-14-11-17(12-16-5-4-6-20(13-16)29-3)22(28)26(25-14)15(2)21(27)24-19-9-7-18(23)8-10-19/h4-11,13,15H,12H2,1-3H3,(H,24,27)
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n/an/an/an/a 32n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295527
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1
Show InChI InChI=1S/C21H21N3O3/c1-15-11-17(12-16-7-6-10-19(13-16)27-2)21(26)24(23-15)14-20(25)22-18-8-4-3-5-9-18/h3-11,13H,12,14H2,1-2H3,(H,22,25)
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n/an/an/an/a 32n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles by chemotaxis assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295524
PNG
(CHEMBL551589 | N-(4-Bromophenyl)-2-[5-(3-methoxybe...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1
Show InChI InChI=1S/C21H20BrN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 34n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295520
PNG
(CHEMBL556485 | N-Benzo[1,3]dioxol-5-yl-2-[5-(3-met...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4OCOc4c3)c2=O)c1
Show InChI InChI=1S/C22H21N3O5/c1-14-8-16(9-15-4-3-5-18(10-15)28-2)22(27)25(24-14)12-21(26)23-17-6-7-19-20(11-17)30-13-29-19/h3-8,10-11H,9,12-13H2,1-2H3,(H,23,26)
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n/an/an/an/a 36n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295519
PNG
(CHEMBL554291 | N-(3,4-Dimethoxyphenyl)-2-[5-(3-met...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1
Show InChI InChI=1S/C23H25N3O5/c1-15-10-17(11-16-6-5-7-19(12-16)29-2)23(28)26(25-15)14-22(27)24-18-8-9-20(30-3)21(13-18)31-4/h5-10,12-13H,11,14H2,1-4H3,(H,24,27)
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n/an/an/an/a 36n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295520
PNG
(CHEMBL556485 | N-Benzo[1,3]dioxol-5-yl-2-[5-(3-met...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4OCOc4c3)c2=O)c1
Show InChI InChI=1S/C22H21N3O5/c1-14-8-16(9-15-4-3-5-18(10-15)28-2)22(27)25(24-14)12-21(26)23-17-6-7-19-20(11-17)30-13-29-19/h3-8,10-11H,9,12-13H2,1-2H3,(H,23,26)
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n/an/an/an/a 36n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles by chemotaxis assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295516
PNG
(CHEMBL552396 | N-(4-Fluorophenyl)-2-[5-(3-methoxyb...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1
Show InChI InChI=1S/C21H20FN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 39n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295516
PNG
(CHEMBL552396 | N-(4-Fluorophenyl)-2-[5-(3-methoxyb...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1
Show InChI InChI=1S/C21H20FN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 39n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles by chemotaxis assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50050946
PNG
((S)-2-{(S)-4-Methyl-2-[(S)-4-methylsulfanyl-2-(3-p...)
Show SMILES CSCC[C@H](NC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C27H36N4O5S/c1-18(2)16-22(25(33)30-23(26(34)35)17-19-10-6-4-7-11-19)29-24(32)21(14-15-37-3)31-27(36)28-20-12-8-5-9-13-20/h4-13,18,21-23H,14-17H2,1-3H3,(H,29,32)(H,30,33)(H,34,35)(H2,28,31,36)/t21-,22-,23-/m0/s1
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n/an/an/an/a 40n/an/an/an/a



Johnson Matthey Biomedical Research

Curated by ChEMBL


Assay Description
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neut...


J Med Chem 39: 1013-5 (1996)


Article DOI: 10.1021/jm950908d
BindingDB Entry DOI: 10.7270/Q2TD9WF6
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295523
PNG
(CHEMBL562380 | N-(4-Bromophenyl)-2-[5-(4-methoxybe...)
Show SMILES COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1
Show InChI InChI=1S/C21H20BrN3O3/c1-14-11-16(12-15-3-9-19(28-2)10-4-15)21(27)25(24-14)13-20(26)23-18-7-5-17(22)6-8-18/h3-11H,12-13H2,1-2H3,(H,23,26)
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n/an/an/an/a 43n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles by chemotaxis assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295521
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(cc3)C(F)(F)F)c2=O)c1
Show InChI InChI=1S/C22H20F3N3O3/c1-14-10-16(11-15-4-3-5-19(12-15)31-2)21(30)28(27-14)13-20(29)26-18-8-6-17(7-9-18)22(23,24)25/h3-10,12H,11,13H2,1-2H3,(H,26,29)
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n/an/an/an/a 57n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295514
PNG
(CHEMBL556625 | N-(4-Chlorophenyl)-2-[5-(3-methoxyb...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 67n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295518
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1
Show InChI InChI=1S/C22H23N3O4/c1-15-11-17(12-16-5-4-6-20(13-16)29-3)22(27)25(24-15)14-21(26)23-18-7-9-19(28-2)10-8-18/h4-11,13H,12,14H2,1-3H3,(H,23,26)
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n/an/an/an/a 77n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295525
PNG
(CHEMBL551590 | N-(4-Bromophenyl)-3-[3-(3-methoxybe...)
Show SMILES COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1
Show InChI InChI=1S/C22H22BrN3O3/c1-15-12-17(13-16-4-3-5-20(14-16)29-2)22(28)26(25-15)11-10-21(27)24-19-8-6-18(23)7-9-19/h3-9,12,14H,10-11,13H2,1-2H3,(H,24,27)
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n/an/an/an/a 97n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295525
PNG
(CHEMBL551590 | N-(4-Bromophenyl)-3-[3-(3-methoxybe...)
Show SMILES COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1
Show InChI InChI=1S/C22H22BrN3O3/c1-15-12-17(13-16-4-3-5-20(14-16)29-2)22(28)26(25-15)11-10-21(27)24-19-8-6-18(23)7-9-19/h3-9,12,14H,10-11,13H2,1-2H3,(H,24,27)
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n/an/an/an/a 113n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles by chemotaxis assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295519
PNG
(CHEMBL554291 | N-(3,4-Dimethoxyphenyl)-2-[5-(3-met...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1
Show InChI InChI=1S/C23H25N3O5/c1-15-10-17(11-16-6-5-7-19(12-16)29-2)23(28)26(25-15)14-22(27)24-18-8-9-20(30-3)21(13-18)31-4/h5-10,12-13H,11,14H2,1-4H3,(H,24,27)
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n/an/an/an/a 155n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50295521
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(cc3)C(F)(F)F)c2=O)c1
Show InChI InChI=1S/C22H20F3N3O3/c1-14-10-16(11-15-4-3-5-19(12-15)31-2)21(30)28(27-14)13-20(29)26-18-8-6-17(7-9-18)22(23,24)25/h3-10,12H,11,13H2,1-2H3,(H,26,29)
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n/an/an/an/a 217n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)


Article DOI: 10.1021/jm900592h
BindingDB Entry DOI: 10.7270/Q2WS8T85
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50097567
PNG
(CHEMBL3588871)
Show SMILES COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(CCCCC2)c2ccc(OC)cn2)cc1
Show InChI InChI=1/C32H37N5O4/c1-40-24-12-10-23(11-13-24)36-31(39)37-28(18-22-19-33-27-9-5-4-8-26(22)27)30(38)35-21-32(16-6-3-7-17-32)29-15-14-25(41-2)20-34-29/h4-5,8-15,19-20,28,33H,3,6-7,16-18,21H2,1-2H3,(H,35,38)(H2,36,37,39)/t28-/s2
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n/an/an/an/a 260n/an/an/an/a



Universit£ degli Studi di Bari Aldo Moro

Curated by ChEMBL


Assay Description
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization


Eur J Med Chem 141: 703-720 (2017)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50050934
PNG
((S)-2-{(S)-2-[(S)-2-(3-Butyl-ureido)-4-methylsulfa...)
Show SMILES CCCCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C25H40N4O5S/c1-5-6-13-26-25(34)29-19(12-14-35-4)22(30)27-20(15-17(2)3)23(31)28-21(24(32)33)16-18-10-8-7-9-11-18/h7-11,17,19-21H,5-6,12-16H2,1-4H3,(H,27,30)(H,28,31)(H,32,33)(H2,26,29,34)/t19-,20-,21-/m0/s1
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n/an/an/an/a 300n/an/an/an/a



Johnson Matthey Biomedical Research

Curated by ChEMBL


Assay Description
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neut...


J Med Chem 39: 1013-5 (1996)


Article DOI: 10.1021/jm950908d
BindingDB Entry DOI: 10.7270/Q2TD9WF6
More data for this
Ligand-Target Pair
Formyl peptide receptor 1


(Homo sapiens (Human))
BDBM50097567
PNG
(CHEMBL3588871)
Show SMILES COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(CCCCC2)c2ccc(OC)cn2)cc1
Show InChI InChI=1/C32H37N5O4/c1-40-24-12-10-23(11-13-24)36-31(39)37-28(18-22-19-33-27-9-5-4-8-26(22)27)30(38)35-21-32(16-6-3-7-17-32)29-15-14-25(41-2)20-34-29/h4-5,8-15,19-20,28,33H,3,6-7,16-18,21H2,1-2H3,(H,35,38)(H2,36,37,39)/t28-/s2
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n/an/an/an/a 430n/an/an/an/a



Universit£ degli Studi di Bari 'Aldo Moro'

Curated by ChEMBL


Assay Description
Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR ass...


Bioorg Med Chem 23: 3913-24 (2015)


Article DOI: 10.1016/j.bmc.2014.12.007
BindingDB Entry DOI: 10.7270/Q2MS3VHB
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50279502
PNG
(CHEMBL4159569)
Show SMILES COc1ccc(NC(=O)N[C@@H](Cc2ccc(cc2)C#N)C(=O)NCC2(CC2)c2ccc(F)c(Cl)c2)cc1
Show InChI InChI=1S/C28H26ClFN4O3/c1-37-22-9-7-21(8-10-22)33-27(36)34-25(14-18-2-4-19(16-31)5-3-18)26(35)32-17-28(12-13-28)20-6-11-24(30)23(29)15-20/h2-11,15,25H,12-14,17H2,1H3,(H,32,35)(H2,33,34,36)/t25-/m0/s1
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n/an/an/an/a 450n/an/an/an/a



Universit£ degli Studi di Bari Aldo Moro

Curated by ChEMBL


Assay Description
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo...


Eur J Med Chem 141: 703-720 (2017)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377327
PNG
(US10265310, Example 84 | trans-ent2-1-(4-chlorophe...)
Show SMILES Clc1ccc(NC(=O)N[C@@H]2CN(CC[C@H]2c2ccccc2)C(=O)C2CC2)cc1
Show InChI InChI=1S/C22H24ClN3O2/c23-17-8-10-18(11-9-17)24-22(28)25-20-14-26(21(27)16-6-7-16)13-12-19(20)15-4-2-1-3-5-15/h1-5,8-11,16,19-20H,6-7,12-14H2,(H2,24,25,28)/t19-,20+/m0/s1
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US Patent
n/an/an/an/a 500n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
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