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Compile Data Set for Download or QSAR

Found 488 hits Enz. Inhib. hit(s) with Target = 'Free fatty acid receptor 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Free fatty acid receptor 2


(Homo sapiens)
BDBM271161
PNG
(7-(2,3-difluorobenzenesulfonyl)-4-(2,2-dimethylmor...)
Show SMILES Cc1nc(N2CCOC(C)(C)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1cccc(F)c1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271162
PNG
(7-(2-fluoro-4-methoxybenzenesulfonyl)-2-methyl-4-[...)
Show SMILES COc1ccc(c(F)c1)S(=O)(=O)c1c(N)[nH]c2c(nc(C)nc12)N1CCO[C@@H](C1)C(F)(F)F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271179
PNG
(7-(2-fluorobenzenesulfonyl)-N2-methyl-4-(2-methylm...)
Show SMILES CNc1nc(N2CCOC(C)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271169
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[(2R)-2-(tr...)
Show SMILES Cc1nc(N2CCO[C@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccc(F)cc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271163
PNG
(7-(4-chloro-2-fluorobenzenesulfonyl)-2-methyl-4-[(...)
Show SMILES Cc1nc(N2CCO[C@@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccc(Cl)cc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271119
PNG
(7-(benzenesulfonyl)-4-(2-methylmorpholin-4-yl)-2-(...)
Show SMILES CSc1nc(N2CCOC(C)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271121
PNG
(7-(benzenesulfonyl)-2-methyl-4-(propan-2-yloxy)-5H...)
Show SMILES CC(C)Oc1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271164
PNG
(7-(2,4-difluorobenzenesulfonyl)-2-methyl-4-[(2S)-2...)
Show SMILES Cc1nc(N2CCO[C@@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccc(F)cc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271165
PNG
(7-(2,3-difluorobenzenesulfonyl)-2-methyl-4-[(2S)-2...)
Show SMILES Cc1nc(N2CCO[C@@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1cccc(F)c1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271170
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[(2R)-2-(tr...)
Show SMILES Cc1nc(N2CCO[C@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271115
PNG
(4-(2-methylmorpholin-4-yl)-7-(phenylsulfanyl)-5H-p...)
Show SMILES CC1CN(CCO1)c1ncnc2c(Sc3ccccc3)c(N)[nH]c12
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271177
PNG
(7-(4-chloro-2-fluorobenzenesulfonyl)-2-methyl-4-[(...)
Show SMILES Cc1nc(N2CCO[C@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccc(Cl)cc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271182
PNG
(7-(2-fluorobenzenesulfonyl)-2-(methylsulfanyl)-4-[...)
Show SMILES CSc1nc(N2CCOC(C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271098
PNG
(7-(benzenesulfonyl)-4-[(2R,5R)-2,5-dimethylmorphol...)
Show SMILES C[C@@H]1CN([C@H](C)CO1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271111
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[2-(trifluo...)
Show SMILES Cc1nc(N2CCOC(C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271173
PNG
(7-(2,5-difluorobenzenesulfonyl)-2-methyl-4-[(2S)-2...)
Show SMILES Cc1nc(N2CCO[C@@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1cc(F)ccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271146
PNG
(7-(3-fluorobenzenesulfonyl)-4-(2-methylmorpholin-4...)
Show SMILES CC1CN(CCO1)c1nc(nc2c(c(N)[nH]c12)S(=O)(=O)c1cccc(F)c1)C(F)(F)F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271160
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[(2S)-2-(tr...)
Show SMILES Cc1nc(N2CCO[C@@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271166
PNG
(7-(2,6-difluorobenzenesulfonyl)-4-(2,2-dimethylmor...)
Show SMILES Cc1nc(N2CCOC(C)(C)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1c(F)cccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271171
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[(2R)-2-(tr...)
Show SMILES Cc1nc(N2CCO[C@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1cc(F)ccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271172
PNG
(7-(2-fluoro-4-methoxybenzenesulfonyl)-2-methyl-4-[...)
Show SMILES COc1ccc(c(F)c1)S(=O)(=O)c1c(N)[nH]c2c(nc(C)nc12)N1CCO[C@H](C1)C(F)(F)F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270890
PNG
(7-(benzenesulfonyl)-4-(piperidin-1-yl)-5H-pyrrolo[...)
Show SMILES Nc1[nH]c2c(ncnc2c1S(=O)(=O)c1ccccc1)N1CCCCC1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271183
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[2-methyl-2...)
Show SMILES Cc1nc(N2CCOC(C)(C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271088
PNG
(4-cyclopentyl-7-(3-fluorobenzenesulfonyl)-2-methyl...)
Show SMILES Cc1nc(C2CCCC2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1cccc(F)c1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271112
PNG
(7-(2-fluoro-4-methoxybenzenesulfonyl)-2-methyl-4-[...)
Show SMILES COc1ccc(c(F)c1)S(=O)(=O)c1c(N)[nH]c2c(nc(C)nc12)N1CCO[C@@H](C)C1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271113
PNG
(4-[(2R,5R)-2,5-dimethylmorpholin-4-yl]-7-(2-fluoro...)
Show SMILES C[C@@H]1CN([C@H](C)CO1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271175
PNG
(4-[(2,2-dimethyloxan-3-yl)oxy]-7-(2-fluorobenzenes...)
Show SMILES Cc1nc(OC2CCCOC2(C)C)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271147
PNG
(7-(2-fluoro-5-methoxybenzenesulfonyl)-2-methyl-4-(...)
Show SMILES COc1ccc(F)c(c1)S(=O)(=O)c1c(N)[nH]c2c(nc(C)nc12)N1CCOC(C)C1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271077
PNG
(7-(benzenesulfonyl)-4-(2-ethylthiomorpholin-4-yl)-...)
Show SMILES CCC1CN(CCS1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271174
PNG
(7-(2,6-Difluorobenzenesulfonyl)-2-methyl-4-[(2S)-2...)
Show SMILES Cc1nc(N2CCO[C@@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1c(F)cccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271159
PNG
(7-(4-chloro-2-fluorobenzenesulfonyl)-4-(2,2-dimeth...)
Show SMILES Cc1nc(N2CCOC(C)(C)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccc(Cl)cc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271142
PNG
(7-(2,6-difluorobenzenesulfonyl)-2-methyl-4-(2-meth...)
Show SMILES CC1CN(CCO1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1c(F)cccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271067
PNG
(7-(benzenesulfonyl)-4-N-ethyl-4-N-(oxan-4-ylmethyl...)
Show SMILES CCN(CC1CCOCC1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271178
PNG
(7-(2-fluorobenzenesulfonyl)-4-[(2R)-2-(fluoromethy...)
Show SMILES Cc1nc(N2CCO[C@@H](CF)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271155
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[(1,1,1-tri...)
Show SMILES CC(Oc1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1F)C(F)(F)F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271143
PNG
(7-(2,4-difluorobenzenesulfonyl)-2-methyl-4-(2-meth...)
Show SMILES CC1CN(CCO1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccc(F)cc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271158
PNG
(3-(benzenesulfonyl)-7-(2,2-dimethylmorpholin-4-yl)...)
Show SMILES CC1(C)CN(CCO1)c1ccnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271020
PNG
(7-(benzenesulfonyl)-4-[(2R,6S)-2,6-dimethylmorphol...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271097
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[(2S)-2-met...)
Show SMILES C[C@H]1CN(CCO1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271062
PNG
(4-(4,4-difluoropiperidin-1-yl)-7-(3-fluorobenzenes...)
Show SMILES Cc1nc(N2CCC(F)(F)CC2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1cccc(F)c1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271065
PNG
(7-(benzenesulfonyl)-4-[2-(propan-2-yl)morpholin-4-...)
Show SMILES CC(C)C1CN(CCO1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271057
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-{6-oxa-9-az...)
Show SMILES Cc1nc(N2CCOC3(CCCC3)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271085
PNG
(US10059713, Example 206)
Show SMILES CC1CN(CCO1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)C1CCN(CC1)C(=O)OCc1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271109
PNG
(7-(benzenesulfonyl)-4-(1-cyclopropylethoxy)-2-meth...)
Show SMILES CC(Oc1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1)C1CC1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271103
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-(prop-1-en-...)
Show SMILES CC(=C)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271117
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-{5-oxa-8-az...)
Show SMILES Cc1nc(N2CCOC3(CCC3)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271151
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-(propan-2-y...)
Show SMILES CC(C)Oc1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271075
PNG
(7-(benzenesulfonyl)-4-(2-methylthiomorpholin-4-yl)...)
Show SMILES CC1CN(CCS1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271168
PNG
(7-(2,5-difluorobenzenesulfonyl)-4-(2,2-dimethylmor...)
Show SMILES Cc1nc(N2CCOC(C)(C)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1cc(F)ccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271056
PNG
(US10059713, Example 175)
Show SMILES Nc1[nH]c2c(OCC3CC3(F)F)ncnc2c1S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
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