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Compile Data Set for Download or QSAR

Found 1157 hits Enz. Inhib. hit(s) with Target = 'Free fatty acid receptor 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271161
PNG
(7-(2,3-difluorobenzenesulfonyl)-4-(2,2-dimethylmor...)
Show SMILES Cc1nc(N2CCOC(C)(C)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1cccc(F)c1F
Show InChI InChI=1S/C19H21F2N5O3S/c1-10-23-14-15(18(24-10)26-7-8-29-19(2,3)9-26)25-17(22)16(14)30(27,28)12-6-4-5-11(20)13(12)21/h4-6,25H,7-9,22H2,1-3H3
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271162
PNG
(7-(2-fluoro-4-methoxybenzenesulfonyl)-2-methyl-4-[...)
Show SMILES COc1ccc(c(F)c1)S(=O)(=O)c1c(N)[nH]c2c(nc(C)nc12)N1CCO[C@@H](C1)C(F)(F)F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271179
PNG
(7-(2-fluorobenzenesulfonyl)-N2-methyl-4-(2-methylm...)
Show SMILES CNc1nc(N2CCOC(C)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271169
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[(2R)-2-(tr...)
Show SMILES Cc1nc(N2CCO[C@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccc(F)cc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271163
PNG
(7-(4-chloro-2-fluorobenzenesulfonyl)-2-methyl-4-[(...)
Show SMILES Cc1nc(N2CCO[C@@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccc(Cl)cc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271119
PNG
(7-(benzenesulfonyl)-4-(2-methylmorpholin-4-yl)-2-(...)
Show SMILES CSc1nc(N2CCOC(C)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271121
PNG
(7-(benzenesulfonyl)-2-methyl-4-(propan-2-yloxy)-5H...)
Show SMILES CC(C)Oc1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H18N4O3S/c1-9(2)23-16-13-12(18-10(3)19-16)14(15(17)20-13)24(21,22)11-7-5-4-6-8-11/h4-9,20H,17H2,1-3H3
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271164
PNG
(7-(2,4-difluorobenzenesulfonyl)-2-methyl-4-[(2S)-2...)
Show SMILES Cc1nc(N2CCO[C@@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccc(F)cc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271165
PNG
(7-(2,3-difluorobenzenesulfonyl)-2-methyl-4-[(2S)-2...)
Show SMILES Cc1nc(N2CCO[C@@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1cccc(F)c1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271170
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[(2R)-2-(tr...)
Show SMILES Cc1nc(N2CCO[C@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271115
PNG
(4-(2-methylmorpholin-4-yl)-7-(phenylsulfanyl)-5H-p...)
Show SMILES CC1CN(CCO1)c1ncnc2c(Sc3ccccc3)c(N)[nH]c12
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271177
PNG
(7-(4-chloro-2-fluorobenzenesulfonyl)-2-methyl-4-[(...)
Show SMILES Cc1nc(N2CCO[C@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccc(Cl)cc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271182
PNG
(7-(2-fluorobenzenesulfonyl)-2-(methylsulfanyl)-4-[...)
Show SMILES CSc1nc(N2CCOC(C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271098
PNG
(7-(benzenesulfonyl)-4-[(2R,5R)-2,5-dimethylmorphol...)
Show SMILES C[C@@H]1CN([C@H](C)CO1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271111
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[2-(trifluo...)
Show SMILES Cc1nc(N2CCOC(C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271173
PNG
(7-(2,5-difluorobenzenesulfonyl)-2-methyl-4-[(2S)-2...)
Show SMILES Cc1nc(N2CCO[C@@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1cc(F)ccc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271146
PNG
(7-(3-fluorobenzenesulfonyl)-4-(2-methylmorpholin-4...)
Show SMILES CC1CN(CCO1)c1nc(nc2c(c(N)[nH]c12)S(=O)(=O)c1cccc(F)c1)C(F)(F)F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271160
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[(2S)-2-(tr...)
Show SMILES Cc1nc(N2CCO[C@@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271166
PNG
(7-(2,6-difluorobenzenesulfonyl)-4-(2,2-dimethylmor...)
Show SMILES Cc1nc(N2CCOC(C)(C)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1c(F)cccc1F
Show InChI InChI=1S/C19H21F2N5O3S/c1-10-23-13-14(18(24-10)26-7-8-29-19(2,3)9-26)25-17(22)16(13)30(27,28)15-11(20)5-4-6-12(15)21/h4-6,25H,7-9,22H2,1-3H3
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271171
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[(2R)-2-(tr...)
Show SMILES Cc1nc(N2CCO[C@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1cc(F)ccc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271172
PNG
(7-(2-fluoro-4-methoxybenzenesulfonyl)-2-methyl-4-[...)
Show SMILES COc1ccc(c(F)c1)S(=O)(=O)c1c(N)[nH]c2c(nc(C)nc12)N1CCO[C@H](C1)C(F)(F)F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM270890
PNG
(7-(benzenesulfonyl)-4-(piperidin-1-yl)-5H-pyrrolo[...)
Show SMILES Nc1[nH]c2c(ncnc2c1S(=O)(=O)c1ccccc1)N1CCCCC1
Show InChI InChI=1S/C17H19N5O2S/c18-16-15(25(23,24)12-7-3-1-4-8-12)13-14(21-16)17(20-11-19-13)22-9-5-2-6-10-22/h1,3-4,7-8,11,21H,2,5-6,9-10,18H2
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271183
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[2-methyl-2...)
Show SMILES Cc1nc(N2CCOC(C)(C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271088
PNG
(4-cyclopentyl-7-(3-fluorobenzenesulfonyl)-2-methyl...)
Show SMILES Cc1nc(C2CCCC2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C18H19FN4O2S/c1-10-21-14(11-5-2-3-6-11)15-16(22-10)17(18(20)23-15)26(24,25)13-8-4-7-12(19)9-13/h4,7-9,11,23H,2-3,5-6,20H2,1H3
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271112
PNG
(7-(2-fluoro-4-methoxybenzenesulfonyl)-2-methyl-4-[...)
Show SMILES COc1ccc(c(F)c1)S(=O)(=O)c1c(N)[nH]c2c(nc(C)nc12)N1CCO[C@@H](C)C1
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271113
PNG
(4-[(2R,5R)-2,5-dimethylmorpholin-4-yl]-7-(2-fluoro...)
Show SMILES C[C@@H]1CN([C@H](C)CO1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271175
PNG
(4-[(2,2-dimethyloxan-3-yl)oxy]-7-(2-fluorobenzenes...)
Show SMILES Cc1nc(OC2CCCOC2(C)C)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271147
PNG
(7-(2-fluoro-5-methoxybenzenesulfonyl)-2-methyl-4-(...)
Show SMILES COc1ccc(F)c(c1)S(=O)(=O)c1c(N)[nH]c2c(nc(C)nc12)N1CCOC(C)C1
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271077
PNG
(7-(benzenesulfonyl)-4-(2-ethylthiomorpholin-4-yl)-...)
Show SMILES CCC1CN(CCS1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271174
PNG
(7-(2,6-Difluorobenzenesulfonyl)-2-methyl-4-[(2S)-2...)
Show SMILES Cc1nc(N2CCO[C@@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1c(F)cccc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271159
PNG
(7-(4-chloro-2-fluorobenzenesulfonyl)-4-(2,2-dimeth...)
Show SMILES Cc1nc(N2CCOC(C)(C)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccc(Cl)cc1F
Show InChI InChI=1S/C19H21ClFN5O3S/c1-10-23-14-15(18(24-10)26-6-7-29-19(2,3)9-26)25-17(22)16(14)30(27,28)13-5-4-11(20)8-12(13)21/h4-5,8,25H,6-7,9,22H2,1-3H3
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271142
PNG
(7-(2,6-difluorobenzenesulfonyl)-2-methyl-4-(2-meth...)
Show SMILES CC1CN(CCO1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1c(F)cccc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271067
PNG
(7-(benzenesulfonyl)-4-N-ethyl-4-N-(oxan-4-ylmethyl...)
Show SMILES CCN(CC1CCOCC1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H25N5O3S/c1-2-25(12-14-8-10-28-11-9-14)20-17-16(22-13-23-20)18(19(21)24-17)29(26,27)15-6-4-3-5-7-15/h3-7,13-14,24H,2,8-12,21H2,1H3
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271178
PNG
(7-(2-fluorobenzenesulfonyl)-4-[(2R)-2-(fluoromethy...)
Show SMILES Cc1nc(N2CCO[C@@H](CF)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271155
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[(1,1,1-tri...)
Show SMILES CC(Oc1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1F)C(F)(F)F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271143
PNG
(7-(2,4-difluorobenzenesulfonyl)-2-methyl-4-(2-meth...)
Show SMILES CC1CN(CCO1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccc(F)cc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271158
PNG
(3-(benzenesulfonyl)-7-(2,2-dimethylmorpholin-4-yl)...)
Show SMILES CC1(C)CN(CCO1)c1ccnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H22N4O3S/c1-19(2)12-23(10-11-26-19)14-8-9-21-16-15(14)22-18(20)17(16)27(24,25)13-6-4-3-5-7-13/h3-9,22H,10-12,20H2,1-2H3
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271020
PNG
(7-(benzenesulfonyl)-4-[(2R,6S)-2,6-dimethylmorphol...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271097
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[(2S)-2-met...)
Show SMILES C[C@H]1CN(CCO1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1F
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271062
PNG
(4-(4,4-difluoropiperidin-1-yl)-7-(3-fluorobenzenes...)
Show SMILES Cc1nc(N2CCC(F)(F)CC2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C18H18F3N5O2S/c1-10-23-13-14(17(24-10)26-7-5-18(20,21)6-8-26)25-16(22)15(13)29(27,28)12-4-2-3-11(19)9-12/h2-4,9,25H,5-8,22H2,1H3
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271065
PNG
(7-(benzenesulfonyl)-4-[2-(propan-2-yl)morpholin-4-...)
Show SMILES CC(C)C1CN(CCO1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271057
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-{6-oxa-9-az...)
Show SMILES Cc1nc(N2CCOC3(CCCC3)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C21H24FN5O3S/c1-13-24-16-17(20(25-13)27-10-11-30-21(12-27)8-4-5-9-21)26-19(23)18(16)31(28,29)15-7-3-2-6-14(15)22/h2-3,6-7,26H,4-5,8-12,23H2,1H3
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271085
PNG
(US10059713, Example 206)
Show SMILES CC1CN(CCO1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)C1CCN(CC1)C(=O)OCc1ccccc1
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271109
PNG
(7-(benzenesulfonyl)-4-(1-cyclopropylethoxy)-2-meth...)
Show SMILES CC(Oc1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1)C1CC1
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271103
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-(prop-1-en-...)
Show SMILES CC(=C)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C16H15FN4O2S/c1-8(2)12-13-14(20-9(3)19-12)15(16(18)21-13)24(22,23)11-7-5-4-6-10(11)17/h4-7,21H,1,18H2,2-3H3
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271117
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-{5-oxa-8-az...)
Show SMILES Cc1nc(N2CCOC3(CCC3)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C20H22FN5O3S/c1-12-23-15-16(19(24-12)26-9-10-29-20(11-26)7-4-8-20)25-18(22)17(15)30(27,28)14-6-3-2-5-13(14)21/h2-3,5-6,25H,4,7-11,22H2,1H3
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271151
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-(propan-2-y...)
Show SMILES CC(C)Oc1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C16H17FN4O3S/c1-8(2)24-16-13-12(19-9(3)20-16)14(15(18)21-13)25(22,23)11-7-5-4-6-10(11)17/h4-8,21H,18H2,1-3H3
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271075
PNG
(7-(benzenesulfonyl)-4-(2-methylthiomorpholin-4-yl)...)
Show SMILES CC1CN(CCS1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271168
PNG
(7-(2,5-difluorobenzenesulfonyl)-4-(2,2-dimethylmor...)
Show SMILES Cc1nc(N2CCOC(C)(C)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1cc(F)ccc1F
Show InChI InChI=1S/C19H21F2N5O3S/c1-10-23-14-15(18(24-10)26-6-7-29-19(2,3)9-26)25-17(22)16(14)30(27,28)13-8-11(20)4-5-12(13)21/h4-5,8,25H,6-7,9,22H2,1-3H3
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM271056
PNG
(US10059713, Example 175)
Show SMILES Nc1[nH]c2c(OCC3CC3(F)F)ncnc2c1S(=O)(=O)c1ccccc1
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)


BindingDB Entry DOI: 10.7270/Q2251M7X
More data for this
Ligand-Target Pair
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