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Compile Data Set for Download or QSAR

Found 119 hits Enz. Inhib. hit(s) with Target = 'Free fatty acid receptor 3'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527464
PNG
(CHEMBL4564389)
Show SMILES CC1=C(C(c2ccco2)C2=C(CCCC2=O)N1)C(=O)Nc1cc(Cl)ccc1Cl
Show InChI InChI=1S/C21H18Cl2N2O3/c1-11-18(21(27)25-15-10-12(22)7-8-13(15)23)20(17-6-3-9-28-17)19-14(24-11)4-2-5-16(19)26/h3,6-10,20,24H,2,4-5H2,1H3,(H,25,27)
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n/an/an/an/a 129n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527492
PNG
(CHEMBL4436229)
Show SMILES CCCC1C(C(=O)Nc2cc(Cl)ccc2Cl)=C(C)NC2=C1C(=O)CCC2
Show InChI InChI=1S/C20H22Cl2N2O2/c1-3-5-13-18(11(2)23-15-6-4-7-17(25)19(13)15)20(26)24-16-10-12(21)8-9-14(16)22/h8-10,13,23H,3-7H2,1-2H3,(H,24,26)
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n/an/an/an/a 145n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527468
PNG
(CHEMBL4530642)
Show SMILES CC1=C(C(C2CCCC2)C2=C(CCCC2=O)N1)C(=O)Nc1cc(Cl)ccc1Cl
Show InChI InChI=1S/C22H24Cl2N2O2/c1-12-19(22(28)26-17-11-14(23)9-10-15(17)24)20(13-5-2-3-6-13)21-16(25-12)7-4-8-18(21)27/h9-11,13,20,25H,2-8H2,1H3,(H,26,28)
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n/an/an/an/a 162n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527489
PNG
(CHEMBL4567723)
Show SMILES CC1=C(C(c2ncco2)C2=C(CCCC2=O)N1)C(=O)Nc1cc(Cl)ccc1Cl
Show InChI InChI=1S/C20H17Cl2N3O3/c1-10-16(19(27)25-14-9-11(21)5-6-12(14)22)18(20-23-7-8-28-20)17-13(24-10)3-2-4-15(17)26/h5-9,18,24H,2-4H2,1H3,(H,25,27)
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n/an/an/an/a 191n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527499
PNG
(CHEMBL4547569)
Show SMILES CC1=C(C(c2ccc(Br)o2)C2=C(CCCC2=O)N1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C22H21BrN2O3/c1-12-6-3-4-7-14(12)25-22(27)19-13(2)24-15-8-5-9-16(26)20(15)21(19)17-10-11-18(23)28-17/h3-4,6-7,10-11,21,24H,5,8-9H2,1-2H3,(H,25,27)
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n/an/an/an/a 245n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527501
PNG
(CHEMBL4442868)
Show SMILES CC1=C(C(C2CC2)C2=C(CCCC2=O)N1)C(=O)Nc1cc(Cl)ccc1Cl
Show InChI InChI=1S/C20H20Cl2N2O2/c1-10-17(20(26)24-15-9-12(21)7-8-13(15)22)18(11-5-6-11)19-14(23-10)3-2-4-16(19)25/h7-9,11,18,23H,2-6H2,1H3,(H,24,26)
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n/an/an/an/a 251n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527488
PNG
(CHEMBL4581781)
Show SMILES CC1=C(C(c2nccs2)C2=C(CCCC2=O)N1)C(=O)Nc1cc(Cl)ccc1Cl
Show InChI InChI=1S/C20H17Cl2N3O2S/c1-10-16(19(27)25-14-9-11(21)5-6-12(14)22)18(20-23-7-8-28-20)17-13(24-10)3-2-4-15(17)26/h5-9,18,24H,2-4H2,1H3,(H,25,27)
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n/an/an/an/a 251n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527484
PNG
(CHEMBL4584743)
Show SMILES CCCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2
Show InChI InChI=1S/C22H28N2O2/c1-4-5-10-16-20(22(26)24-17-11-7-6-9-14(17)2)15(3)23-18-12-8-13-19(25)21(16)18/h6-7,9,11,16,23H,4-5,8,10,12-13H2,1-3H3,(H,24,26)
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n/an/an/an/a 263n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527505
PNG
(CHEMBL4513816)
Show SMILES CC1=C(C(C2CCCC2)C2=C(CCCC2=O)N1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C23H28N2O2/c1-14-8-3-6-11-17(14)25-23(27)20-15(2)24-18-12-7-13-19(26)22(18)21(20)16-9-4-5-10-16/h3,6,8,11,16,21,24H,4-5,7,9-10,12-13H2,1-2H3,(H,25,27)
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n/an/an/an/a 288n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527498
PNG
(CHEMBL4473184)
Show SMILES CCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2
Show InChI InChI=1S/C20H24N2O2/c1-4-14-18(20(24)22-15-9-6-5-8-12(15)2)13(3)21-16-10-7-11-17(23)19(14)16/h5-6,8-9,14,21H,4,7,10-11H2,1-3H3,(H,22,24)
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n/an/an/an/a 355n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527474
PNG
(CHEMBL4567192)
Show SMILES COc1ccccc1NC(=O)C1=C(C)NC2=C(C1c1ccco1)C(=O)CCC2
Show InChI InChI=1S/C22H22N2O4/c1-13-19(22(26)24-14-7-3-4-10-17(14)27-2)21(18-11-6-12-28-18)20-15(23-13)8-5-9-16(20)25/h3-4,6-7,10-12,21,23H,5,8-9H2,1-2H3,(H,24,26)
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n/an/an/an/a 372n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527481
PNG
(CHEMBL4560915)
Show SMILES CC(C)CC1C(C#N)=C(C)NC(C)=C1C(=O)Nc1ccccc1C
Show InChI InChI=1S/C20H25N3O/c1-12(2)10-16-17(11-21)14(4)22-15(5)19(16)20(24)23-18-9-7-6-8-13(18)3/h6-9,12,16,22H,10H2,1-5H3,(H,23,24)
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n/an/an/an/a 380n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527465
PNG
(CHEMBL4516265)
Show SMILES CCCCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2
Show InChI InChI=1S/C23H30N2O2/c1-4-5-6-11-17-21(23(27)25-18-12-8-7-10-15(18)2)16(3)24-19-13-9-14-20(26)22(17)19/h7-8,10,12,17,24H,4-6,9,11,13-14H2,1-3H3,(H,25,27)
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n/an/an/an/a 398n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Rattus norvegicus)
BDBM50527468
PNG
(CHEMBL4530642)
Show SMILES CC1=C(C(C2CCCC2)C2=C(CCCC2=O)N1)C(=O)Nc1cc(Cl)ccc1Cl
Show InChI InChI=1S/C22H24Cl2N2O2/c1-12-19(22(28)26-17-11-14(23)9-10-15(17)24)20(13-5-2-3-6-13)21-16(25-12)7-4-8-18(21)27/h9-11,13,20,25H,2-8H2,1H3,(H,26,28)
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n/an/an/an/a 407n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat FFA3 receptor


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Rattus norvegicus)
BDBM50527464
PNG
(CHEMBL4564389)
Show SMILES CC1=C(C(c2ccco2)C2=C(CCCC2=O)N1)C(=O)Nc1cc(Cl)ccc1Cl
Show InChI InChI=1S/C21H18Cl2N2O3/c1-11-18(21(27)25-15-10-12(22)7-8-13(15)23)20(17-6-3-9-28-17)19-14(24-11)4-2-5-16(19)26/h3,6-10,20,24H,2,4-5H2,1H3,(H,25,27)
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n/an/an/an/a 457n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat FFA3 receptor


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527510
PNG
(CHEMBL4447610)
Show SMILES CCC(C)C1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2
Show InChI InChI=1S/C22H28N2O2/c1-5-13(2)19-20(22(26)24-16-10-7-6-9-14(16)3)15(4)23-17-11-8-12-18(25)21(17)19/h6-7,9-10,13,19,23H,5,8,11-12H2,1-4H3,(H,24,26)
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n/an/an/an/a 501n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527469
PNG
(CHEMBL4448591)
Show SMILES CC1=C(C(c2ccco2)C2=C(CCCC2=O)N1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C22H22N2O3/c1-13-7-3-4-8-15(13)24-22(26)19-14(2)23-16-9-5-10-17(25)20(16)21(19)18-11-6-12-27-18/h3-4,6-8,11-12,21,23H,5,9-10H2,1-2H3,(H,24,26)
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n/an/an/an/a 525n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527475
PNG
(CHEMBL4470184)
Show SMILES CC(C)CC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2
Show InChI InChI=1S/C22H28N2O2/c1-13(2)12-16-20(22(26)24-17-9-6-5-8-14(17)3)15(4)23-18-10-7-11-19(25)21(16)18/h5-6,8-9,13,16,23H,7,10-12H2,1-4H3,(H,24,26)
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n/an/an/an/a 525n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527469
PNG
(CHEMBL4448591)
Show SMILES CC1=C(C(c2ccco2)C2=C(CCCC2=O)N1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C22H22N2O3/c1-13-7-3-4-8-15(13)24-22(26)19-14(2)23-16-9-5-10-17(25)20(16)21(19)18-11-6-12-27-18/h3-4,6-8,11-12,21,23H,5,9-10H2,1-2H3,(H,24,26)
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n/an/an/an/a 537n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527478
PNG
(CHEMBL4569482)
Show SMILES CC1=C(C(c2ccoc2)C2=C(CCCC2=O)N1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C22H22N2O3/c1-13-6-3-4-7-16(13)24-22(26)19-14(2)23-17-8-5-9-18(25)21(17)20(19)15-10-11-27-12-15/h3-4,6-7,10-12,20,23H,5,8-9H2,1-2H3,(H,24,26)
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n/an/an/an/a 537n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527503
PNG
(CHEMBL4567938)
Show SMILES CC1=C(C(CCc2ccccc2)C2=C(CCCC2=O)N1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C26H28N2O2/c1-17-9-6-7-12-21(17)28-26(30)24-18(2)27-22-13-8-14-23(29)25(22)20(24)16-15-19-10-4-3-5-11-19/h3-7,9-12,20,27H,8,13-16H2,1-2H3,(H,28,30)
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n/an/an/an/a 589n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527483
PNG
(CHEMBL4547759)
Show SMILES CC1=C(C(C2CC2)C2=C(CCCC2=O)N1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C21H24N2O2/c1-12-6-3-4-7-15(12)23-21(25)18-13(2)22-16-8-5-9-17(24)20(16)19(18)14-10-11-14/h3-4,6-7,14,19,22H,5,8-11H2,1-2H3,(H,23,25)
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n/an/an/an/a 603n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527508
PNG
(CHEMBL4470725)
Show SMILES COC(=O)C1=C(C)NC2=C(C1CC(C)C)C(=O)CCC2
Show InChI InChI=1S/C16H23NO3/c1-9(2)8-11-14(16(19)20-4)10(3)17-12-6-5-7-13(18)15(11)12/h9,11,17H,5-8H2,1-4H3
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n/an/an/an/a 617n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527491
PNG
(CHEMBL4440835)
Show SMILES CCCC1C(C(=O)Nc2cc(C)ccc2Cl)=C(C)NC2=C1C(=O)CCC2
Show InChI InChI=1S/C21H25ClN2O2/c1-4-6-14-19(13(3)23-16-7-5-8-18(25)20(14)16)21(26)24-17-11-12(2)9-10-15(17)22/h9-11,14,23H,4-8H2,1-3H3,(H,24,26)
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n/an/an/an/a 646n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527463
PNG
(CHEMBL4545039)
Show SMILES CC1=C(C(c2ccco2)C2=C(CCCC2=O)N1)C(=O)Nc1ccc(C)cc1
Show InChI InChI=1S/C22H22N2O3/c1-13-8-10-15(11-9-13)24-22(26)19-14(2)23-16-5-3-6-17(25)20(16)21(19)18-7-4-12-27-18/h4,7-12,21,23H,3,5-6H2,1-2H3,(H,24,26)
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n/an/an/an/a 692n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527502
PNG
(CHEMBL4515057)
Show SMILES COC(=O)C1=C(C)NC(C)=C(C1CC(C)C)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C21H28N2O3/c1-12(2)11-16-18(14(4)22-15(5)19(16)21(25)26-6)20(24)23-17-10-8-7-9-13(17)3/h7-10,12,16,22H,11H2,1-6H3,(H,23,24)
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n/an/an/an/a 692n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527493
PNG
(CHEMBL4457531)
Show SMILES CCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2
Show InChI InChI=1S/C21H26N2O2/c1-4-8-15-19(21(25)23-16-10-6-5-9-13(16)2)14(3)22-17-11-7-12-18(24)20(15)17/h5-6,9-10,15,22H,4,7-8,11-12H2,1-3H3,(H,23,25)
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n/an/an/an/a 692n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527462
PNG
(CHEMBL4452922)
Show SMILES CC(C)CC1C(C(=O)Nc2ccccc2Cl)=C(C)NC2=C1C(=O)CCC2
Show InChI InChI=1S/C21H25ClN2O2/c1-12(2)11-14-19(21(26)24-16-8-5-4-7-15(16)22)13(3)23-17-9-6-10-18(25)20(14)17/h4-5,7-8,12,14,23H,6,9-11H2,1-3H3,(H,24,26)
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n/an/an/an/a 708n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527494
PNG
(CHEMBL4443269)
Show SMILES CC1=C(C(\C=C\c2ccccc2)C2=C(CCCC2=O)N1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C26H26N2O2/c1-17-9-6-7-12-21(17)28-26(30)24-18(2)27-22-13-8-14-23(29)25(22)20(24)16-15-19-10-4-3-5-11-19/h3-7,9-12,15-16,20,27H,8,13-14H2,1-2H3,(H,28,30)/b16-15+
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n/an/an/an/a 724n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527511
PNG
(CHEMBL4592426)
Show SMILES CCCC1C(C(=O)Nc2ccccc2Cl)=C(C)NC2=C1C(=O)CCC2
Show InChI InChI=1S/C20H23ClN2O2/c1-3-7-13-18(20(25)23-15-9-5-4-8-14(15)21)12(2)22-16-10-6-11-17(24)19(13)16/h4-5,8-9,13,22H,3,6-7,10-11H2,1-2H3,(H,23,25)
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n/an/an/an/a 871n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527486
PNG
(CHEMBL4439667)
Show SMILES CC1=C(C(c2cc3ccccc3o2)C2=C(CCCC2=O)N1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C26H24N2O3/c1-15-8-3-5-10-18(15)28-26(30)23-16(2)27-19-11-7-12-20(29)24(19)25(23)22-14-17-9-4-6-13-21(17)31-22/h3-6,8-10,13-14,25,27H,7,11-12H2,1-2H3,(H,28,30)
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n/an/an/an/a 1.00E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527490
PNG
(CHEMBL4450056)
Show SMILES CCCC1C(C(=O)Nc2cccc(Cl)c2)=C(C)NC2=C1C(=O)CCC2
Show InChI InChI=1S/C20H23ClN2O2/c1-3-6-15-18(20(25)23-14-8-4-7-13(21)11-14)12(2)22-16-9-5-10-17(24)19(15)16/h4,7-8,11,15,22H,3,5-6,9-10H2,1-2H3,(H,23,25)
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n/an/an/an/a 1.07E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Mus musculus)
BDBM50527468
PNG
(CHEMBL4530642)
Show SMILES CC1=C(C(C2CCCC2)C2=C(CCCC2=O)N1)C(=O)Nc1cc(Cl)ccc1Cl
Show InChI InChI=1S/C22H24Cl2N2O2/c1-12-19(22(28)26-17-11-14(23)9-10-15(17)24)20(13-5-2-3-6-13)21-16(25-12)7-4-8-18(21)27/h9-11,13,20,25H,2-8H2,1H3,(H,26,28)
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n/an/an/an/a 1.10E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at mouse FFA3 receptor


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527507
PNG
(CHEMBL4476587)
Show SMILES CCCC1C(C(=O)Nc2cc(OC)ccc2Cl)=C(C)NC2=C1C(=O)CCC2
Show InChI InChI=1S/C21H25ClN2O3/c1-4-6-14-19(12(2)23-16-7-5-8-18(25)20(14)16)21(26)24-17-11-13(27-3)9-10-15(17)22/h9-11,14,23H,4-8H2,1-3H3,(H,24,26)
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n/an/an/an/a 1.10E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527485
PNG
(CHEMBL4449702)
Show SMILES Cc1ccc(o1)C1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2
Show InChI InChI=1S/C23H24N2O3/c1-13-7-4-5-8-16(13)25-23(27)20-15(3)24-17-9-6-10-18(26)21(17)22(20)19-12-11-14(2)28-19/h4-5,7-8,11-12,22,24H,6,9-10H2,1-3H3,(H,25,27)
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n/an/an/an/a 1.10E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527466
PNG
(CHEMBL4570341)
Show SMILES CC1=C(C(c2cccs2)C2=C(CCCC2=O)N1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C22H22N2O2S/c1-13-7-3-4-8-15(13)24-22(26)19-14(2)23-16-9-5-10-17(25)20(16)21(19)18-11-6-12-27-18/h3-4,6-8,11-12,21,23H,5,9-10H2,1-2H3,(H,24,26)
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n/an/an/an/a 1.20E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527493
PNG
(CHEMBL4457531)
Show SMILES CCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2
Show InChI InChI=1S/C21H26N2O2/c1-4-8-15-19(21(25)23-16-10-6-5-9-13(16)2)14(3)22-17-11-7-12-18(24)20(15)17/h5-6,9-10,15,22H,4,7-8,11-12H2,1-3H3,(H,23,25)
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n/an/an/an/a 1.20E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527470
PNG
(CHEMBL4578663)
Show SMILES CC1=C(C(C2=C(CCCC2=O)N1)c1ccccc1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C24H24N2O2/c1-15-9-6-7-12-18(15)26-24(28)21-16(2)25-19-13-8-14-20(27)23(19)22(21)17-10-4-3-5-11-17/h3-7,9-12,22,25H,8,13-14H2,1-2H3,(H,26,28)
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n/an/an/an/a 1.23E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Mus musculus)
BDBM50527464
PNG
(CHEMBL4564389)
Show SMILES CC1=C(C(c2ccco2)C2=C(CCCC2=O)N1)C(=O)Nc1cc(Cl)ccc1Cl
Show InChI InChI=1S/C21H18Cl2N2O3/c1-11-18(21(27)25-15-10-12(22)7-8-13(15)23)20(17-6-3-9-28-17)19-14(24-11)4-2-5-16(19)26/h3,6-10,20,24H,2,4-5H2,1H3,(H,25,27)
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n/an/an/an/a 1.32E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at mouse FFA3 receptor


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527509
PNG
(CHEMBL4574477)
Show SMILES CC1=C(C(C2=C(CCCC2=O)N1)c1cccc(Br)c1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C24H23BrN2O2/c1-14-7-3-4-10-18(14)27-24(29)21-15(2)26-19-11-6-12-20(28)23(19)22(21)16-8-5-9-17(25)13-16/h3-5,7-10,13,22,26H,6,11-12H2,1-2H3,(H,27,29)
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n/an/an/an/a 1.35E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Rattus norvegicus)
BDBM50527469
PNG
(CHEMBL4448591)
Show SMILES CC1=C(C(c2ccco2)C2=C(CCCC2=O)N1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C22H22N2O3/c1-13-7-3-4-8-15(13)24-22(26)19-14(2)23-16-9-5-10-17(25)20(16)21(19)18-11-6-12-27-18/h3-4,6-8,11-12,21,23H,5,9-10H2,1-2H3,(H,24,26)
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n/an/an/an/a 1.35E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat FFA3 receptor


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527484
PNG
(CHEMBL4584743)
Show SMILES CCCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2
Show InChI InChI=1S/C22H28N2O2/c1-4-5-10-16-20(22(26)24-17-11-7-6-9-14(17)2)15(3)23-18-12-8-13-19(25)21(16)18/h6-7,9,11,16,23H,4-5,8,10,12-13H2,1-3H3,(H,24,26)
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n/an/an/an/a 1.38E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527512
PNG
(CHEMBL4471380)
Show SMILES Cc1csc(c1)C1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2
Show InChI InChI=1S/C23H24N2O2S/c1-13-11-19(28-12-13)22-20(23(27)25-16-8-5-4-7-14(16)2)15(3)24-17-9-6-10-18(26)21(17)22/h4-5,7-8,11-12,22,24H,6,9-10H2,1-3H3,(H,25,27)
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n/an/an/an/a 1.38E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527504
PNG
(CHEMBL4470372)
Show SMILES CC1=C(C(c2ccco2)C2=C(CCCC2=O)N1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C22H22N2O3/c1-13-6-3-7-15(12-13)24-22(26)19-14(2)23-16-8-4-9-17(25)20(16)21(19)18-10-5-11-27-18/h3,5-7,10-12,21,23H,4,8-9H2,1-2H3,(H,24,26)
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n/an/an/an/a 1.59E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527479
PNG
(CHEMBL4517214)
Show SMILES CC1=C(C(C2=C(CCCC2=O)N1)c1ccc(Br)cc1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C24H23BrN2O2/c1-14-6-3-4-7-18(14)27-24(29)21-15(2)26-19-8-5-9-20(28)23(19)22(21)16-10-12-17(25)13-11-16/h3-4,6-7,10-13,22,26H,5,8-9H2,1-2H3,(H,27,29)
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n/an/an/an/a 1.62E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527466
PNG
(CHEMBL4570341)
Show SMILES CC1=C(C(c2cccs2)C2=C(CCCC2=O)N1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C22H22N2O2S/c1-13-7-3-4-8-15(13)24-22(26)19-14(2)23-16-9-5-10-17(25)20(16)21(19)18-11-6-12-27-18/h3-4,6-8,11-12,21,23H,5,9-10H2,1-2H3,(H,24,26)
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n/an/an/an/a 1.62E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527513
PNG
(CHEMBL4443263)
Show SMILES CC1=C(C(c2cocn2)C2=C(CCCC2=O)N1)C(=O)Nc1cc(Cl)ccc1Cl
Show InChI InChI=1S/C20H17Cl2N3O3/c1-10-17(20(27)25-14-7-11(21)5-6-12(14)22)19(15-8-28-9-23-15)18-13(24-10)3-2-4-16(18)26/h5-9,19,24H,2-4H2,1H3,(H,25,27)
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n/an/an/an/a 1.66E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527500
PNG
(CHEMBL4470404)
Show SMILES CC1=C(C(c2cncs2)C2=C(CCCC2=O)N1)C(=O)Nc1cc(Cl)ccc1Cl
Show InChI InChI=1S/C20H17Cl2N3O2S/c1-10-17(20(27)25-14-7-11(21)5-6-12(14)22)19(16-8-23-9-28-16)18-13(24-10)3-2-4-15(18)26/h5-9,19,24H,2-4H2,1H3,(H,25,27)
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n/an/an/an/a 1.78E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527464
PNG
(CHEMBL4564389)
Show SMILES CC1=C(C(c2ccco2)C2=C(CCCC2=O)N1)C(=O)Nc1cc(Cl)ccc1Cl
Show InChI InChI=1S/C21H18Cl2N2O3/c1-11-18(21(27)25-15-10-12(22)7-8-13(15)23)20(17-6-3-9-28-17)19-14(24-11)4-2-5-16(19)26/h3,6-10,20,24H,2,4-5H2,1H3,(H,25,27)
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n/an/an/an/a 1.82E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding meas...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50527506
PNG
(CHEMBL4579352)
Show SMILES CC1=C(C(c2cscn2)C2=C(CCCC2=O)N1)C(=O)Nc1cc(Cl)ccc1Cl
Show InChI InChI=1S/C20H17Cl2N3O2S/c1-10-17(20(27)25-14-7-11(21)5-6-12(14)22)19(15-8-28-9-23-15)18-13(24-10)3-2-4-16(18)26/h5-9,19,24H,2-4H2,1H3,(H,25,27)
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n/an/an/an/a 1.95E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
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