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Compile Data Set for Download or QSAR

Found 4081 hits Enz. Inhib. hit(s) with Target = 'G protein-coupled receptor 44'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50163942
PNG
((Z)-7-[(1R,4S,5R)-5-Hydroxy-2-((R)-3-hydroxy-3-met...)
Show SMILES CCCCC[C@@](C)(O)\C=C\[C@@H]1[C@@H](C\C=C\CCCC(O)=O)[C@@H](O)CC1=O
Show InChI InChI=1S/C21H34O5/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25/h5,7,12,14,16-18,22,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25)/b7-5+,14-12+/t16-,17-,18+,21-/m1/s1
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n/an/an/an/a 1.40n/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Effective concentration DP2 mediated expression of the adhesion molecule CD11b in eosinophils


Bioorg Med Chem Lett 15: 1873-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.011
BindingDB Entry DOI: 10.7270/Q2WQ0396
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50163942
PNG
((Z)-7-[(1R,4S,5R)-5-Hydroxy-2-((R)-3-hydroxy-3-met...)
Show SMILES CCCCC[C@@](C)(O)\C=C\[C@@H]1[C@@H](C\C=C\CCCC(O)=O)[C@@H](O)CC1=O
Show InChI InChI=1S/C21H34O5/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25/h5,7,12,14,16-18,22,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25)/b7-5+,14-12+/t16-,17-,18+,21-/m1/s1
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n/an/an/an/a 1.70n/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Effective concentration for DP2 mediated chemotaxis in eosinophils


Bioorg Med Chem Lett 15: 1873-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.011
BindingDB Entry DOI: 10.7270/Q2WQ0396
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM231198
PNG
(US9556139, 106 Enantiomer 2 106)
Show SMILES OC(=O)[C@H]1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccc(Cl)cc3Cl)c(Cl)cc12
Show InChI InChI=1S/C25H20Cl3NO5/c26-16-4-1-14(20(27)11-16)7-9-29-24(30)15-2-5-17(6-3-15)34-23-13-22-19(12-21(23)28)18(25(31)32)8-10-33-22/h1-6,11-13,18H,7-10H2,(H,29,30)(H,31,32)/t18-/m0/s1
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n/an/an/an/a 2.65n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50163942
PNG
((Z)-7-[(1R,4S,5R)-5-Hydroxy-2-((R)-3-hydroxy-3-met...)
Show SMILES CCCCC[C@@](C)(O)\C=C\[C@@H]1[C@@H](C\C=C\CCCC(O)=O)[C@@H](O)CC1=O
Show InChI InChI=1S/C21H34O5/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25/h5,7,12,14,16-18,22,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25)/b7-5+,14-12+/t16-,17-,18+,21-/m1/s1
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n/an/an/an/a 3.80n/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Effective concentration for DP2 mediated stimulation of actin polymerization in eosinophils


Bioorg Med Chem Lett 15: 1873-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.011
BindingDB Entry DOI: 10.7270/Q2WQ0396
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM231191
PNG
(Sodium 6-chloro-7-(4-(4-chloro-2-methoxyphenethylc...)
Show SMILES COc1cc(Cl)ccc1CCNC(=O)c1ccc(Oc2cc3OCCC(C(O)=O)c3cc2Cl)cc1
Show InChI InChI=1S/C26H23Cl2NO6/c1-33-22-12-17(27)5-2-15(22)8-10-29-25(30)16-3-6-18(7-4-16)35-24-14-23-20(13-21(24)28)19(26(31)32)9-11-34-23/h2-7,12-14,19H,8-11H2,1H3,(H,29,30)(H,31,32)
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n/an/an/an/a 5.10n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM231168
PNG
(6-Cyano-7-(4-(naphthalen-2-ylcarbamoyl)phenoxy)chr...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)Nc3ccc4ccccc4c3)c(cc12)C#N
Show InChI InChI=1S/C28H20N2O5/c29-16-20-14-24-23(28(32)33)11-12-34-26(24)15-25(20)35-22-9-6-18(7-10-22)27(31)30-21-8-5-17-3-1-2-4-19(17)13-21/h1-10,13-15,23H,11-12H2,(H,30,31)(H,32,33)
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n/an/an/an/a 6.70n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50163943
PNG
((Z)-7-[(1R,2R,5S)-5-Hydroxy-2-((E)-(S)-3-hydroxy-o...)
Show SMILES CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C\CCCC(O)=O)[C@@H](O)CC1=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4+,13-12+/t15-,16+,17+,18-/m0/s1
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n/an/an/an/a 7n/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Effective concentration DP2 mediated expression of the adhesion molecule CD11b in eosinophils


Bioorg Med Chem Lett 15: 1873-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.011
BindingDB Entry DOI: 10.7270/Q2WQ0396
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM231194
PNG
(Sodium 6-chloro-7-(4-(2-methoxy-4-(trifluoromethyl...)
Show SMILES COc1cc(ccc1CCNC(=O)c1ccc(Oc2cc3OCCC(C(O)=O)c3cc2Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C27H23ClF3NO6/c1-36-22-12-17(27(29,30)31)5-2-15(22)8-10-32-25(33)16-3-6-18(7-4-16)38-24-14-23-20(13-21(24)28)19(26(34)35)9-11-37-23/h2-7,12-14,19H,8-11H2,1H3,(H,32,33)(H,34,35)
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n/an/an/an/a 7.70n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230043
PNG
(US9556139, 11 Enantiomer 2)
Show SMILES OC(=O)[C@@H]1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccccc3)c(Cl)cc12
Show InChI InChI=1S/C25H22ClNO5/c26-21-14-20-19(25(29)30)11-13-31-22(20)15-23(21)32-18-8-6-17(7-9-18)24(28)27-12-10-16-4-2-1-3-5-16/h1-9,14-15,19H,10-13H2,(H,27,28)(H,29,30)/t19-/m1/s1
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n/an/an/an/a 9.30n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50163943
PNG
((Z)-7-[(1R,2R,5S)-5-Hydroxy-2-((E)-(S)-3-hydroxy-o...)
Show SMILES CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C\CCCC(O)=O)[C@@H](O)CC1=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4+,13-12+/t15-,16+,17+,18-/m0/s1
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n/an/an/an/a 10n/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Effective concentration for DP2 mediated chemotaxis in eosinophils


Bioorg Med Chem Lett 15: 1873-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.011
BindingDB Entry DOI: 10.7270/Q2WQ0396
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230066
PNG
(Sodium 6-chloro-7-(4-(4-chloro-2-cyclopropylphenet...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccc(Cl)cc3C3CC3)c(Cl)cc12
Show InChI InChI=1S/C28H25Cl2NO5/c29-19-6-3-17(22(13-19)16-1-2-16)9-11-31-27(32)18-4-7-20(8-5-18)36-26-15-25-23(14-24(26)30)21(28(33)34)10-12-35-25/h3-8,13-16,21H,1-2,9-12H2,(H,31,32)(H,33,34)
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n/an/an/an/a 10.5n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM228438
PNG
(Ethyl 6-chloro-7-hydroxychroman-4-carboxylate | US...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccc(Cl)cc3Cl)c(cc12)C#N
Show InChI InChI=1S/C26H20Cl2N2O5/c27-18-4-1-15(22(28)12-18)7-9-30-25(31)16-2-5-19(6-3-16)35-23-13-24-21(11-17(23)14-29)20(26(32)33)8-10-34-24/h1-6,11-13,20H,7-10H2,(H,30,31)(H,32,33)
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n/an/an/an/a 10.7n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230543
PNG
(7-(4-((4-(Trifluoromethyl)phenethyl)carbamoyl)phen...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccc(cc3)C(F)(F)F)c(cc12)C#N
Show InChI InChI=1S/C27H21F3N2O5/c28-27(29,30)19-5-1-16(2-6-19)9-11-32-25(33)17-3-7-20(8-4-17)37-23-14-24-22(13-18(23)15-31)21(26(34)35)10-12-36-24/h1-8,13-14,21H,9-12H2,(H,32,33)(H,34,35)
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n/an/an/an/a 11n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50312283
PNG
((+/-)-cis-N-(1-benzoyl-2-methyl-1,2,3,4-tetrahydro...)
Show SMILES C[C@H]1C[C@@H](N(C(C)=O)c2ccccc2)c2ccccc2N1C(=O)c1ccccc1
Show InChI InChI=1S/C25H24N2O2/c1-18-17-24(27(19(2)28)21-13-7-4-8-14-21)22-15-9-10-16-23(22)26(18)25(29)20-11-5-3-6-12-20/h3-16,18,24H,17H2,1-2H3/t18-,24+/m0/s1
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n/an/an/an/a 11n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in CEM cell assessed as inhibition of PGD2-induced cell migration after 3 hrs by transwell migr...


Bioorg Med Chem Lett 19: 6840-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.094
BindingDB Entry DOI: 10.7270/Q2N58MHF
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM234930
PNG
(6-Chloro-7-(4-(4-chloro-2-hydroxyphenethylcarbamoy...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccc(Cl)cc3O)c(Cl)cc12
Show InChI InChI=1S/C25H21Cl2NO6/c26-16-4-1-14(21(29)11-16)7-9-28-24(30)15-2-5-17(6-3-15)34-23-13-22-19(12-20(23)27)18(25(31)32)8-10-33-22/h1-6,11-13,18,29H,7-10H2,(H,28,30)(H,31,32)
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n/an/an/an/a 11.1n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM231155
PNG
(6-Cyano-7-(4-(4-(trifluoromethyl)phenylcarbamoyl)p...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)Nc3ccc(cc3)C(F)(F)F)c(cc12)C#N
Show InChI InChI=1S/C25H17F3N2O5/c26-25(27,28)16-3-5-17(6-4-16)30-23(31)14-1-7-18(8-2-14)35-21-12-22-20(11-15(21)13-29)19(24(32)33)9-10-34-22/h1-8,11-12,19H,9-10H2,(H,30,31)(H,32,33)
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n/an/an/an/a 11.9n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230069
PNG
(Sodium 6-chloro-7-(4-(2,4-dichloro-6-methoxyphenet...)
Show SMILES COc1cc(Cl)cc(Cl)c1CCNC(=O)c1ccc(Oc2cc3OCCC(C(O)=O)c3cc2Cl)cc1
Show InChI InChI=1S/C26H22Cl3NO6/c1-34-22-11-15(27)10-20(28)18(22)6-8-30-25(31)14-2-4-16(5-3-14)36-24-13-23-19(12-21(24)29)17(26(32)33)7-9-35-23/h2-5,10-13,17H,6-9H2,1H3,(H,30,31)(H,32,33)
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n/an/an/an/a 12n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230608
PNG
(7-(4-((2-(4-Chlorophenyl)cyclopropyl)carbamoyl)phe...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NC3CC3c3ccc(Cl)cc3)c(cc12)C#N
Show InChI InChI=1S/C27H21ClN2O5/c28-18-5-1-15(2-6-18)21-12-23(21)30-26(31)16-3-7-19(8-4-16)35-24-13-25-22(11-17(24)14-29)20(27(32)33)9-10-34-25/h1-8,11,13,20-21,23H,9-10,12H2,(H,30,31)(H,32,33)
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n/an/an/an/a 12.1n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230643
PNG
(6-Cyano-7-(4-(2-(naphthalen-1-yl)ethylcarbamoyl)ph...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3cccc4ccccc34)c(cc12)C#N
Show InChI InChI=1S/C30H24N2O5/c31-18-22-16-26-25(30(34)35)13-15-36-28(26)17-27(22)37-23-10-8-21(9-11-23)29(33)32-14-12-20-6-3-5-19-4-1-2-7-24(19)20/h1-11,16-17,25H,12-15H2,(H,32,33)(H,34,35)
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n/an/an/an/a 12.1n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230079
PNG
(7-(4-((2-Phenylcyclopropyl)carbamoyl)phenoxy)-6-cy...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NC3CC3c3ccccc3)c(cc12)C#N
Show InChI InChI=1S/C27H22N2O5/c28-15-18-12-22-20(27(31)32)10-11-33-25(22)14-24(18)34-19-8-6-17(7-9-19)26(30)29-23-13-21(23)16-4-2-1-3-5-16/h1-9,12,14,20-21,23H,10-11,13H2,(H,29,30)(H,31,32)
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n/an/an/an/a 12.1n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50163943
PNG
((Z)-7-[(1R,2R,5S)-5-Hydroxy-2-((E)-(S)-3-hydroxy-o...)
Show SMILES CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C\CCCC(O)=O)[C@@H](O)CC1=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4+,13-12+/t15-,16+,17+,18-/m0/s1
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n/an/an/an/a 13n/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Effective concentration for DP2 mediated stimulation of actin polymerization in eosinophils


Bioorg Med Chem Lett 15: 1873-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.011
BindingDB Entry DOI: 10.7270/Q2WQ0396
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230042
PNG
(6-Chloro-7-(4-(4-chlorophenethylcarbamoyl)phenoxy)...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccc(Cl)cc3)c(Cl)cc12
Show InChI InChI=1S/C25H21Cl2NO5/c26-17-5-1-15(2-6-17)9-11-28-24(29)16-3-7-18(8-4-16)33-23-14-22-20(13-21(23)27)19(25(30)31)10-12-32-22/h1-8,13-14,19H,9-12H2,(H,28,29)(H,30,31)
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n/an/an/an/a 13.9n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230644
PNG
(6-Cyano-7-(4-(2-(naphthalen-2-yl)ethylcarbamoyl)ph...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccc4ccccc4c3)c(cc12)C#N
Show InChI InChI=1S/C30H24N2O5/c31-18-23-16-26-25(30(34)35)12-14-36-28(26)17-27(23)37-24-9-7-21(8-10-24)29(33)32-13-11-19-5-6-20-3-1-2-4-22(20)15-19/h1-10,15-17,25H,11-14H2,(H,32,33)(H,34,35)
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n/an/an/an/a 14.2n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230608
PNG
(7-(4-((2-(4-Chlorophenyl)cyclopropyl)carbamoyl)phe...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NC3CC3c3ccc(Cl)cc3)c(cc12)C#N
Show InChI InChI=1S/C27H21ClN2O5/c28-18-5-1-15(2-6-18)21-12-23(21)30-26(31)16-3-7-19(8-4-16)35-24-13-25-22(11-17(24)14-29)20(27(32)33)9-10-34-25/h1-8,11,13,20-21,23H,9-10,12H2,(H,30,31)(H,32,33)
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n/an/an/an/a 14.8n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230078
PNG
(Sodium 6,8-dichloro-7-(4-(4-chlorophenethylcarbamo...)
Show SMILES OC(=O)C1CCOc2c(Cl)c(Oc3ccc(cc3)C(=O)NCCc3ccc(Cl)cc3)c(Cl)cc12
Show InChI InChI=1S/C25H20Cl3NO5/c26-16-5-1-14(2-6-16)9-11-29-24(30)15-3-7-17(8-4-15)34-23-20(27)13-19-18(25(31)32)10-12-33-22(19)21(23)28/h1-8,13,18H,9-12H2,(H,29,30)(H,31,32)
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n/an/an/an/a 15.8n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230040
PNG
(2-(4-Chloro-2-methoxyphenyl)ethanamine | US9556139...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)Nc3ccc(Cl)c(Cl)c3)c(cc12)C#N
Show InChI InChI=1S/C24H16Cl2N2O5/c25-19-6-3-15(10-20(19)26)28-23(29)13-1-4-16(5-2-13)33-21-11-22-18(9-14(21)12-27)17(24(30)31)7-8-32-22/h1-6,9-11,17H,7-8H2,(H,28,29)(H,30,31)
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n/an/an/an/a 16n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM234939
PNG
(US9556139, 238 Enantiomer 2)
Show SMILES COc1cc(ccc1CCNC(=O)c1ccc(Oc2cc3OCC[C@@H](C(O)=O)c3cc2Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C27H23ClF3NO6/c1-36-22-12-17(27(29,30)31)5-2-15(22)8-10-32-25(33)16-3-6-18(7-4-16)38-24-14-23-20(13-21(24)28)19(26(34)35)9-11-37-23/h2-7,12-14,19H,8-11H2,1H3,(H,32,33)(H,34,35)/t19-/m1/s1
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n/an/an/an/a 16.2n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM232977
PNG
(Sodium 6-chloro-7-(4-(2,4-dimethoxyphenethylcarbam...)
Show SMILES COc1ccc(CCNC(=O)c2ccc(Oc3cc4OCCC(C(O)=O)c4cc3Cl)cc2)c(OC)c1
Show InChI InChI=1S/C27H26ClNO7/c1-33-19-8-3-16(23(13-19)34-2)9-11-29-26(30)17-4-6-18(7-5-17)36-25-15-24-21(14-22(25)28)20(27(31)32)10-12-35-24/h3-8,13-15,20H,9-12H2,1-2H3,(H,29,30)(H,31,32)
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n/an/an/an/a 16.4n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM228392
PNG
(6-Cyano-7-(4-(4-chlorophenylcarbamoyl)phenoxy)chro...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccc(Cl)cc3)c(cc12)C#N
Show InChI InChI=1S/C26H21ClN2O5/c27-19-5-1-16(2-6-19)9-11-29-25(30)17-3-7-20(8-4-17)34-23-14-24-22(13-18(23)15-28)21(26(31)32)10-12-33-24/h1-8,13-14,21H,9-12H2,(H,29,30)(H,31,32)
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n/an/an/an/a 16.6n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM234933
PNG
(US9556139, 235 Enantiomer 2)
Show SMILES COc1cc(ccc1CCNC(=O)c1ccc(Oc2cc3OCC[C@@H](C(O)=O)c3cc2Cl)cc1)C1CC1
Show InChI InChI=1S/C29H28ClNO6/c1-35-25-14-20(17-2-3-17)5-4-18(25)10-12-31-28(32)19-6-8-21(9-7-19)37-27-16-26-23(15-24(27)30)22(29(33)34)11-13-36-26/h4-9,14-17,22H,2-3,10-13H2,1H3,(H,31,32)(H,33,34)/t22-/m1/s1
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n/an/an/an/a 17n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230068
PNG
(Sodium 6-chloro-7-(4-(4-cyclopropyl-2-methoxyphene...)
Show SMILES COc1cc(ccc1CCNC(=O)c1ccc(Oc2cc3OCCC(C(O)=O)c3cc2Cl)cc1)C1CC1
Show InChI InChI=1S/C29H28ClNO6/c1-35-25-14-20(17-2-3-17)5-4-18(25)10-12-31-28(32)19-6-8-21(9-7-19)37-27-16-26-23(15-24(27)30)22(29(33)34)11-13-36-26/h4-9,14-17,22H,2-3,10-13H2,1H3,(H,31,32)(H,33,34)
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n/an/an/an/a 17.3n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230645
PNG
(7-(4-(4-tert-Butylphenethylcarbamoyl)phenoxy)-6-cy...)
Show SMILES CC(C)(C)c1ccc(CCNC(=O)c2ccc(Oc3cc4OCCC(C(O)=O)c4cc3C#N)cc2)cc1
Show InChI InChI=1S/C30H30N2O5/c1-30(2,3)22-8-4-19(5-9-22)12-14-32-28(33)20-6-10-23(11-7-20)37-26-17-27-25(16-21(26)18-31)24(29(34)35)13-15-36-27/h4-11,16-17,24H,12-15H2,1-3H3,(H,32,33)(H,34,35)
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n/an/an/an/a 18.9n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM21599
PNG
(2-{5-chloro-1'-[(3-methyl-5-phenyl-1,2-oxazol-4-yl...)
Show SMILES Cc1noc(c1CN1CC2(CC1=O)C(=O)N(CC(O)=O)c1ccc(Cl)cc21)-c1ccccc1
Show InChI InChI=1S/C24H20ClN3O5/c1-14-17(22(33-26-14)15-5-3-2-4-6-15)11-27-13-24(10-20(27)29)18-9-16(25)7-8-19(18)28(23(24)32)12-21(30)31/h2-9H,10-13H2,1H3,(H,30,31)
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3.80n/an/an/a 19n/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...


J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230039
PNG
(US9556139, 7)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NOCc3ccc(Cl)cc3)c(cc12)C#N
Show InChI InChI=1S/C25H19ClN2O6/c26-18-5-1-15(2-6-18)14-33-28-24(29)16-3-7-19(8-4-16)34-22-12-23-21(11-17(22)13-27)20(25(30)31)9-10-32-23/h1-8,11-12,20H,9-10,14H2,(H,28,29)(H,30,31)
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n/an/an/an/a 19n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM21594
PNG
(2-{5-chloro-1'-[(5-methyl-3-phenyl-1,2-oxazol-4-yl...)
Show SMILES Cc1onc(c1CN1C(=O)CC2(C1=O)C(=O)N(CC(O)=O)c1ccc(Cl)cc21)-c1ccccc1
Show InChI InChI=1S/C24H18ClN3O6/c1-13-16(21(26-34-13)14-5-3-2-4-6-14)11-28-19(29)10-24(23(28)33)17-9-15(25)7-8-18(17)27(22(24)32)12-20(30)31/h2-9H,10-12H2,1H3,(H,30,31)
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7.60n/an/an/a 21n/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...


J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM234931
PNG
(US9556139, 234 Enantiomer 2)
Show SMILES OC(=O)[C@@H]1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccc(Cl)cc3C3CC3)c(Cl)cc12
Show InChI InChI=1S/C28H25Cl2NO5/c29-19-6-3-17(22(13-19)16-1-2-16)9-11-31-27(32)18-4-7-20(8-5-18)36-26-15-25-23(14-24(26)30)21(28(33)34)10-12-35-25/h3-8,13-16,21H,1-2,9-12H2,(H,31,32)(H,33,34)/t21-/m1/s1
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n/an/an/an/a 21.7n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM231253
PNG
(7-(4-(4-Chlorophenethylcarbamoyl)-2-methylphenoxy)...)
Show SMILES Cc1cc(ccc1Oc1cc2OCCC(C(O)=O)c2cc1C#N)C(=O)NCCc1ccc(Cl)cc1
Show InChI InChI=1S/C27H23ClN2O5/c1-16-12-18(26(31)30-10-8-17-2-5-20(28)6-3-17)4-7-23(16)35-24-14-25-22(13-19(24)15-29)21(27(32)33)9-11-34-25/h2-7,12-14,21H,8-11H2,1H3,(H,30,31)(H,32,33)
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n/an/an/an/a 21.9n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230498
PNG
(7-(4-((4-Fluorophenethyl)carbamoyl)phenoxy)-6-cyan...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccc(F)cc3)c(cc12)C#N
Show InChI InChI=1S/C26H21FN2O5/c27-19-5-1-16(2-6-19)9-11-29-25(30)17-3-7-20(8-4-17)34-23-14-24-22(13-18(23)15-28)21(26(31)32)10-12-33-24/h1-8,13-14,21H,9-12H2,(H,29,30)(H,31,32)
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n/an/an/an/a 22.5n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM21595
PNG
(2-{5-chloro-1'-[(3-methyl-5-phenyl-1,2-oxazol-4-yl...)
Show SMILES Cc1noc(c1CN1C(=O)CC2(C1=O)C(=O)N(CC(O)=O)c1ccc(Cl)cc21)-c1ccccc1
Show InChI InChI=1S/C24H18ClN3O6/c1-13-16(21(34-26-13)14-5-3-2-4-6-14)11-28-19(29)10-24(23(28)33)17-9-15(25)7-8-18(17)27(22(24)32)12-20(30)31/h2-9H,10-12H2,1H3,(H,30,31)
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5.30n/an/an/a 23n/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...


J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM231153
PNG
(7-(4-(4-Chlorophenylcarbamoyl)phenoxy)-6-cyanochro...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)Nc3ccc(Cl)cc3)c(cc12)C#N
Show InChI InChI=1S/C24H17ClN2O5/c25-16-3-5-17(6-4-16)27-23(28)14-1-7-18(8-2-14)32-21-12-22-20(11-15(21)13-26)19(24(29)30)9-10-31-22/h1-8,11-12,19H,9-10H2,(H,27,28)(H,29,30)
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n/an/an/an/a 23.3n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50296977
PNG
(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Show SMILES Cc1c(Cc2ccc3ccccc3n2)c2cc(F)ccc2n1CC(O)=O
Show InChI InChI=1S/C21H17FN2O2/c1-13-17(11-16-8-6-14-4-2-3-5-19(14)23-16)18-10-15(22)7-9-20(18)24(13)12-21(25)26/h2-10H,11-12H2,1H3,(H,25,26)
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PubMed
n/an/an/an/a 24n/an/an/an/a



Oxagen Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 in human eosinophils assessed as inhibition of PGD2-induced shape change


J Med Chem 55: 2915-31 (2012)


Article DOI: 10.1021/jm2013997
BindingDB Entry DOI: 10.7270/Q2Z0398R
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM234937
PNG
(US9556139, 237 Enantiomer 2)
Show SMILES COc1cc(Cl)ccc1CCNC(=O)c1ccc(Oc2cc3OCC[C@@H](C(O)=O)c3cc2Cl)cc1
Show InChI InChI=1S/C26H23Cl2NO6/c1-33-22-12-17(27)5-2-15(22)8-10-29-25(30)16-3-6-18(7-4-16)35-24-14-23-20(13-21(24)28)19(26(31)32)9-11-34-23/h2-7,12-14,19H,8-11H2,1H3,(H,29,30)(H,31,32)/t19-/m1/s1
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n/an/an/an/a 25.6n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM231500
PNG
(6-Cyano-7-(4-((R)-2-phenylpropylcarbamoyl)phenoxy)...)
Show SMILES C[C@@H](CNC(=O)c1ccc(Oc2cc3OCCC(C(O)=O)c3cc2C#N)cc1)c1ccccc1
Show InChI InChI=1S/C27H24N2O5/c1-17(18-5-3-2-4-6-18)16-29-26(30)19-7-9-21(10-8-19)34-24-14-25-23(13-20(24)15-28)22(27(31)32)11-12-33-25/h2-10,13-14,17,22H,11-12,16H2,1H3,(H,29,30)(H,31,32)/t17-,22?/m0/s1
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n/an/an/an/a 25.7n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM234904
PNG
(US9556139, 207 | sodium 6-chloro-7-(4-(4-chloro-2-...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccc(Cl)cc3Oc3ccccc3)c(Cl)cc12
Show InChI InChI=1S/C31H25Cl2NO6/c32-21-9-6-19(27(16-21)39-22-4-2-1-3-5-22)12-14-34-30(35)20-7-10-23(11-8-20)40-29-18-28-25(17-26(29)33)24(31(36)37)13-15-38-28/h1-11,16-18,24H,12-15H2,(H,34,35)(H,36,37)
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n/an/an/an/a 26.4n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230080
PNG
(7-(4-((3-Methoxyphenethyl)carbamoyl)phenoxy)-6-cya...)
Show SMILES COc1cccc(CCNC(=O)c2ccc(Oc3cc4OCCC(C(O)=O)c4cc3C#N)cc2)c1
Show InChI InChI=1S/C27H24N2O6/c1-33-21-4-2-3-17(13-21)9-11-29-26(30)18-5-7-20(8-6-18)35-24-15-25-23(14-19(24)16-28)22(27(31)32)10-12-34-25/h2-8,13-15,22H,9-12H2,1H3,(H,29,30)(H,31,32)
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n/an/an/an/a 30.7n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM234935
PNG
(US9556139, 236 Enantiomer 2)
Show SMILES COc1cc(Cl)cc(Cl)c1CCNC(=O)c1ccc(Oc2cc3OCC[C@@H](C(O)=O)c3cc2Cl)cc1
Show InChI InChI=1S/C26H22Cl3NO6/c1-34-22-11-15(27)10-20(28)18(22)6-8-30-25(31)14-2-4-16(5-3-14)36-24-13-23-19(12-21(24)29)17(26(32)33)7-9-35-23/h2-5,10-13,17H,6-9H2,1H3,(H,30,31)(H,32,33)/t17-/m1/s1
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n/an/an/an/a 34n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM231147
PNG
(6-Cyano-7-(4-(1,2,3,4-tetrahydronaphthalen-2-ylcar...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NC3CCc4ccccc4C3)c(cc12)C#N
Show InChI InChI=1S/C28H24N2O5/c29-16-20-14-24-23(28(32)33)11-12-34-26(24)15-25(20)35-22-9-6-18(7-10-22)27(31)30-21-8-5-17-3-1-2-4-19(17)13-21/h1-4,6-7,9-10,14-15,21,23H,5,8,11-13H2,(H,30,31)(H,32,33)
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n/an/an/an/a 36.4n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM234908
PNG
(US9556139, 211 | sodium 6-chloro-7-(4-(4-chloro- 2...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccc(Cl)cc3Oc3cccc(Cl)c3)c(Cl)cc12
Show InChI InChI=1S/C31H24Cl3NO6/c32-20-2-1-3-23(14-20)41-27-15-21(33)7-4-18(27)10-12-35-30(36)19-5-8-22(9-6-19)40-29-17-28-25(16-26(29)34)24(31(37)38)11-13-39-28/h1-9,14-17,24H,10-13H2,(H,35,36)(H,37,38)
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n/an/an/an/a 37.2n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM231643
PNG
(7-(4-(1-(4-Chlorophenyl)propan-2-ylcarbamoyl)pheno...)
Show SMILES CC(Cc1ccc(Cl)cc1)NC(=O)c1ccc(Oc2cc3OCCC(C(O)=O)c3cc2C#N)cc1
Show InChI InChI=1S/C27H23ClN2O5/c1-16(12-17-2-6-20(28)7-3-17)30-26(31)18-4-8-21(9-5-18)35-24-14-25-23(13-19(24)15-29)22(27(32)33)10-11-34-25/h2-9,13-14,16,22H,10-12H2,1H3,(H,30,31)(H,32,33)
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n/an/an/an/a 37.4n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM230037
PNG
(6-Cyano-7-(4-(phenethylcarbamoyl)phenoxy)chroman-4...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccccc3)c(cc12)C#N
Show InChI InChI=1S/C26H22N2O5/c27-16-19-14-22-21(26(30)31)11-13-32-24(22)15-23(19)33-20-8-6-18(7-9-20)25(29)28-12-10-17-4-2-1-3-5-17/h1-9,14-15,21H,10-13H2,(H,28,29)(H,30,31)
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n/an/an/an/a 37.4n/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...


US Patent US9556139 (2017)

More data for this
Ligand-Target Pair
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