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Found 1648 Enz. Inhib. hit(s) with Target = 'G-protein coupled bile acid receptor 1'
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50156370(CHEMBL3793436)
Affinity DataEC50:  0.0570nMAssay Description:Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50156370(CHEMBL3793436)
Affinity DataEC50:  0.0620nMAssay Description:Agonist activity at mouse TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50399971(CHEMBL2181247)
Affinity DataEC50:  0.230nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50019474(CHEMBL3290717)
Affinity DataEC50:  0.280nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50429128(CHEMBL2336232)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50266580(CHEMBL4087611)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50399970(CHEMBL2181229)
Affinity DataEC50:  0.310nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50552649(CHEMBL4779837)
Affinity DataEC50:  0.330nMAssay Description:Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50266544(CHEMBL4060410)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50019475(CHEMBL3290716)
Affinity DataEC50:  0.450nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50399969(CHEMBL2181227)
Affinity DataEC50:  0.460nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50003570(CHEMBL3234869)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50003559(CHEMBL3234570)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM398287(US10323016, Example 26)
Affinity DataEC50:  0.5nMAssay Description:In the following tables TGR5 activation by compounds and subsequent increase in intracellular cAMP were evaluated using a luciferase reporter gene as...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50399968(CHEMBL2181228)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50399967(CHEMBL2181230)
Affinity DataEC50:  0.720nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50399966(CHEMBL2181226)
Affinity DataEC50:  0.720nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50266552(CHEMBL4094487 | US10323016, Example 20)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50266538(CHEMBL4084668 | US10323016, Example 4)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50565258(CHEMBL4779084)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50019474(CHEMBL3290717)
Affinity DataEC50:  0.920nMAssay Description:Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50399970(CHEMBL2181229)
Affinity DataEC50:  0.980nMAssay Description:Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50266538(CHEMBL4084668 | US10323016, Example 4)
Affinity DataEC50:  1nMAssay Description:In the following tables TGR5 activation by compounds and subsequent increase in intracellular cAMP were evaluated using a luciferase reporter gene as...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50003573(CHEMBL3234871)
Affinity DataEC50:  1nMAssay Description:Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50003569(CHEMBL3234868)
Affinity DataEC50:  1nMAssay Description:Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50003407(CHEMBL3234568)
Affinity DataEC50:  1nMAssay Description:Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50266552(CHEMBL4094487 | US10323016, Example 20)
Affinity DataEC50:  1nMAssay Description:In the following tables TGR5 activation by compounds and subsequent increase in intracellular cAMP were evaluated using a luciferase reporter gene as...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50003559(CHEMBL3234570)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50459101(CHEMBL4213913)
Affinity DataEC50:  1nMAssay Description:Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50415407(CHEMBL612138)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase rep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50552646(CHEMBL4743463)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50552647(CHEMBL4790044)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50429126(CHEMBL2336233)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50429129(CHEMBL2336231)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50459099(CHEMBL4202981)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50459099(CHEMBL4202981)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50019478(CHEMBL3290715)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50399962(CHEMBL2181239)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50019479(CHEMBL3290713)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50160886(CHEMBL3794442)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50428105(CHEMBL2331649)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50272009(CHEMBL4126062)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50019485(CHEMBL3290720)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50429127(CHEMBL2331604)
Affinity DataEC50:  1.80nMAssay Description:Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50003572(CHEMBL3234870)
Affinity DataEC50:  2nMAssay Description:Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50003336(CHEMBL3234565)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50003568(CHEMBL3234583)
Affinity DataEC50:  2nMAssay Description:Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50459138(CHEMBL4209799)
Affinity DataEC50:  2nMAssay Description:Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50003567(CHEMBL3234582)
Affinity DataEC50:  2nMAssay Description:Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50459136(CHEMBL4204655)
Affinity DataEC50:  2nMAssay Description:Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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