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Compile Data Set for Download or QSAR

Found 985 hits Enz. Inhib. hit(s) with Target = 'G-protein coupled receptor 120'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207060
PNG
(CHEMBL3952043)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(OC)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1/C23H26FNO6/c1-28-16-10-17(11-16)31-20-12-19(29-2)22(24)23(25-20)14-4-7-18-13(9-14)3-5-15(30-18)6-8-21(26)27/h4,7,9,12,15-17H,3,5-6,8,10-11H2,1-2H3,(H,26,27)/t15-,16-,17-/s2
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n/an/an/an/a 5n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207050
PNG
(CHEMBL3972870)
Show SMILES Cc1cnc(Oc2cc(Cl)c(F)c(c2)-c2ccc3O[C@@H](CCC(O)=O)CCc3c2)s1
Show InChI InChI=1/C22H19ClFNO4S/c1-12-11-25-22(30-12)29-16-9-17(21(24)18(23)10-16)13-3-6-19-14(8-13)2-4-15(28-19)5-7-20(26)27/h3,6,8-11,15H,2,4-5,7H2,1H3,(H,26,27)/t15-/s2
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n/an/an/an/a 5.60n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207057
PNG
(CHEMBL3960738)
Show SMILES COc1cc(OC2CCC2)nc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1/C22H24FNO5/c1-27-18-12-19(29-15-3-2-4-15)24-22(21(18)23)14-6-9-17-13(11-14)5-7-16(28-17)8-10-20(25)26/h6,9,11-12,15-16H,2-5,7-8,10H2,1H3,(H,25,26)/t16-/s2
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n/an/an/an/a 6.20n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207075
PNG
(CHEMBL3898962)
Show SMILES COc1cc(OC2CCC2)nc(c1F)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1/C23H24FNO5/c1-28-19-11-20(29-14-3-2-4-14)25-22(21(19)24)13-6-7-17-12(9-13)5-8-18(30-17)15-10-16(15)23(26)27/h6-7,9,11,14-16,18H,2-5,8,10H2,1H3,(H,26,27)/t15-,16-,18-/s2
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n/an/an/an/a 7.80n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207058
PNG
(CHEMBL3970166)
Show SMILES COc1cc(OC2CCC2)cc(c1F)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1/C24H25FO5/c1-28-22-11-16(29-15-3-2-4-15)10-17(23(22)25)13-5-7-20-14(9-13)6-8-21(30-20)18-12-19(18)24(26)27/h5,7,9-11,15,18-19,21H,2-4,6,8,12H2,1H3,(H,26,27)/t18-,19-,21-/s2
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n/an/an/an/a 8n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207052
PNG
(CHEMBL3909773)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)cc(Cl)c1F
Show InChI InChI=1/C22H22ClFO4/c23-19-12-17(27-15-2-1-3-15)11-18(22(19)24)13-5-8-20-14(10-13)4-6-16(28-20)7-9-21(25)26/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,25,26)/t16-/s2
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n/an/an/an/a 8.30n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207073
PNG
(CHEMBL3940429)
Show SMILES COc1cc(OC2CCC2)cc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1/C23H25FO5/c1-27-21-13-18(28-16-3-2-4-16)12-19(23(21)24)14-6-9-20-15(11-14)5-7-17(29-20)8-10-22(25)26/h6,9,11-13,16-17H,2-5,7-8,10H2,1H3,(H,25,26)/t17-/s2
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n/an/an/an/a 9n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207056
PNG
(CHEMBL3970238)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)ccc1F
Show InChI InChI=1/C22H23FO4/c23-20-9-7-18(26-16-2-1-3-16)13-19(20)14-5-10-21-15(12-14)4-6-17(27-21)8-11-22(24)25/h5,7,9-10,12-13,16-17H,1-4,6,8,11H2,(H,24,25)/t17-/s2
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n/an/an/an/a 10n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207066
PNG
(CHEMBL3890089)
Show SMILES COc1cc(OC(F)(F)F)cc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1/C20H18F4O5/c1-27-17-10-14(29-20(22,23)24)9-15(19(17)21)11-3-6-16-12(8-11)2-4-13(28-16)5-7-18(25)26/h3,6,8-10,13H,2,4-5,7H2,1H3,(H,25,26)/t13-/s2
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n/an/an/an/a 11n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207064
PNG
(CHEMBL3943315)
Show SMILES COc1cc(Oc2ncc(C)s2)cc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1/C23H22FNO5S/c1-13-12-25-23(31-13)30-17-10-18(22(24)20(11-17)28-2)14-4-7-19-15(9-14)3-5-16(29-19)6-8-21(26)27/h4,7,9-12,16H,3,5-6,8H2,1-2H3,(H,26,27)/t16-/s2
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n/an/an/an/a 13n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207051
PNG
(CHEMBL3947070)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)cc(F)c1F
Show InChI InChI=1/C22H22F2O4/c23-19-12-17(27-15-2-1-3-15)11-18(22(19)24)13-5-8-20-14(10-13)4-6-16(28-20)7-9-21(25)26/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,25,26)/t16-/s2
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n/an/an/an/a 13n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207060
PNG
(CHEMBL3952043)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(OC)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1/C23H26FNO6/c1-28-16-10-17(11-16)31-20-12-19(29-2)22(24)23(25-20)14-4-7-18-13(9-14)3-5-15(30-18)6-8-21(26)27/h4,7,9,12,15-17H,3,5-6,8,10-11H2,1-2H3,(H,26,27)/t15-,16-,17-/s2
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n/an/an/an/a 14n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207050
PNG
(CHEMBL3972870)
Show SMILES Cc1cnc(Oc2cc(Cl)c(F)c(c2)-c2ccc3O[C@@H](CCC(O)=O)CCc3c2)s1
Show InChI InChI=1/C22H19ClFNO4S/c1-12-11-25-22(30-12)29-16-9-17(21(24)18(23)10-16)13-3-6-19-14(8-13)2-4-15(28-19)5-7-20(26)27/h3,6,8-11,15H,2,4-5,7H2,1H3,(H,26,27)/t15-/s2
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n/an/an/an/a 14n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207073
PNG
(CHEMBL3940429)
Show SMILES COc1cc(OC2CCC2)cc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1/C23H25FO5/c1-27-21-13-18(28-16-3-2-4-16)12-19(23(21)24)14-6-9-20-15(11-14)5-7-17(29-20)8-10-22(25)26/h6,9,11-13,16-17H,2-5,7-8,10H2,1H3,(H,25,26)/t17-/s2
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n/an/an/an/a 15n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207057
PNG
(CHEMBL3960738)
Show SMILES COc1cc(OC2CCC2)nc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1/C22H24FNO5/c1-27-18-12-19(29-15-3-2-4-15)24-22(21(18)23)14-6-9-17-13(11-14)5-7-16(28-17)8-10-20(25)26/h6,9,11-12,15-16H,2-5,7-8,10H2,1H3,(H,25,26)/t16-/s2
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n/an/an/an/a 15n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50203653
PNG
(CHEMBL3896657)
Show SMILES OC(=O)CCc1cc2cc(ccc2o1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C18H12F4O4/c19-15-4-2-13(26-18(20,21)22)9-14(15)10-1-5-16-11(7-10)8-12(25-16)3-6-17(23)24/h1-2,4-5,7-9H,3,6H2,(H,23,24)
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n/an/an/an/a 16n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitment


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50203653
PNG
(CHEMBL3896657)
Show SMILES OC(=O)CCc1cc2cc(ccc2o1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C18H12F4O4/c19-15-4-2-13(26-18(20,21)22)9-14(15)10-1-5-16-11(7-10)8-12(25-16)3-6-17(23)24/h1-2,4-5,7-9H,3,6H2,(H,23,24)
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n/an/an/an/a 16n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitment


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207055
PNG
(CHEMBL3960231)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1/C19H16F4O4/c20-16-6-4-14(27-19(21,22)23)10-15(16)11-2-7-17-12(9-11)1-3-13(26-17)5-8-18(24)25/h2,4,6-7,9-10,13H,1,3,5,8H2,(H,24,25)/t13-/s2
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n/an/an/an/a 17n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207062
PNG
(CHEMBL3959144)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)cc(Cl)c1F
Show InChI InChI=1/C19H15ClF4O4/c20-15-9-13(28-19(22,23)24)8-14(18(15)21)10-2-5-16-11(7-10)1-3-12(27-16)4-6-17(25)26/h2,5,7-9,12H,1,3-4,6H2,(H,25,26)/t12-/s2
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n/an/an/an/a 17n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207069
PNG
(CHEMBL3959068)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(c1)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1/C24H24F2O5/c1-29-14-7-15(8-14)30-16-9-17(23(26)20(25)10-16)12-2-4-21-13(6-12)3-5-22(31-21)18-11-19(18)24(27)28/h2,4,6,9-10,14-15,18-19,22H,3,5,7-8,11H2,1H3,(H,27,28)/t14-,15-,18-,19-,22-/s2
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n/an/an/an/a 17n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207075
PNG
(CHEMBL3898962)
Show SMILES COc1cc(OC2CCC2)nc(c1F)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1/C23H24FNO5/c1-28-19-11-20(29-14-3-2-4-14)25-22(21(19)24)13-6-7-17-12(9-13)5-8-18(30-17)15-10-16(15)23(26)27/h6-7,9,11,14-16,18H,2-5,8,10H2,1H3,(H,26,27)/t15-,16-,18-/s2
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n/an/an/an/a 18n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50203658
PNG
(CHEMBL3973101)
Show SMILES OC(=O)CCCOc1c(F)cc(cc1F)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C17H12F6O4/c18-12-4-3-10(27-17(21,22)23)8-11(12)9-6-13(19)16(14(20)7-9)26-5-1-2-15(24)25/h3-4,6-8H,1-2,5H2,(H,24,25)
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n/an/an/an/a 20n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay


Bioorg Med Chem Lett 26: 5724-5728 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.054
BindingDB Entry DOI: 10.7270/Q24Q7WZ2
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207051
PNG
(CHEMBL3947070)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)cc(F)c1F
Show InChI InChI=1/C22H22F2O4/c23-19-12-17(27-15-2-1-3-15)11-18(22(19)24)13-5-8-20-14(10-13)4-6-16(28-20)7-9-21(25)26/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,25,26)/t16-/s2
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n/an/an/an/a 21n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207072
PNG
(CHEMBL3946820)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1nc(OC2CCC2)ccc1F
Show InChI InChI=1/C21H22FNO4/c22-17-8-10-19(27-15-2-1-3-15)23-21(17)14-5-9-18-13(12-14)4-6-16(26-18)7-11-20(24)25/h5,8-10,12,15-16H,1-4,6-7,11H2,(H,24,25)/t16-/s2
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n/an/an/an/a 21n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207061
PNG
(CHEMBL3980898)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1/C22H23F2NO5/c1-28-15-9-16(10-15)30-19-11-17(23)21(24)22(25-19)13-3-6-18-12(8-13)2-4-14(29-18)5-7-20(26)27/h3,6,8,11,14-16H,2,4-5,7,9-10H2,1H3,(H,26,27)/t14-,15-,16-/s2
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n/an/an/an/a 24n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM50278670
PNG
(CHEMBL4171724)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(nsc2C(F)(F)F)-c2ccc(Cl)c(F)c2)c(F)c1
Show InChI InChI=1S/C20H12ClF6NO3S/c21-12-3-2-10(7-13(12)22)17-11(19(32-28-17)20(25,26)27)8-31-18-14(23)5-9(6-15(18)24)1-4-16(29)30/h2-3,5-7H,1,4,8H2,(H,29,30)
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n/an/an/an/a 25n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 m...


ACS Med Chem Lett 8: 947-952 (2017)

More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207066
PNG
(CHEMBL3890089)
Show SMILES COc1cc(OC(F)(F)F)cc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1/C20H18F4O5/c1-27-17-10-14(29-20(22,23)24)9-15(19(17)21)11-3-6-16-12(8-11)2-4-13(28-16)5-7-18(25)26/h3,6,8-10,13H,2,4-5,7H2,1H3,(H,25,26)/t13-/s2
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n/an/an/an/a 25n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207058
PNG
(CHEMBL3970166)
Show SMILES COc1cc(OC2CCC2)cc(c1F)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1/C24H25FO5/c1-28-22-11-16(29-15-3-2-4-15)10-17(23(22)25)13-5-7-20-14(9-13)6-8-21(30-20)18-12-19(18)24(26)27/h5,7,9-11,15,18-19,21H,2-4,6,8,12H2,1H3,(H,26,27)/t18-,19-,21-/s2
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n/an/an/an/a 25n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207056
PNG
(CHEMBL3970238)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)ccc1F
Show InChI InChI=1/C22H23FO4/c23-20-9-7-18(26-16-2-1-3-16)13-19(20)14-5-10-21-15(12-14)4-6-17(27-21)8-11-22(24)25/h5,7,9-10,12-13,16-17H,1-4,6,8,11H2,(H,24,25)/t17-/s2
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n/an/an/an/a 28n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207072
PNG
(CHEMBL3946820)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1nc(OC2CCC2)ccc1F
Show InChI InChI=1/C21H22FNO4/c22-17-8-10-19(27-15-2-1-3-15)23-21(17)14-5-9-18-13(12-14)4-6-16(26-18)7-11-20(24)25/h5,8-10,12,15-16H,1-4,6-7,11H2,(H,24,25)/t16-/s2
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n/an/an/an/a 30n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM50278677
PNG
(CHEMBL4162566)
Show SMILES OC(=O)CCc1ccc(OCc2c(nsc2C(F)(F)F)-c2ccc(Cl)cc2)c(Br)c1
Show InChI InChI=1S/C20H14BrClF3NO3S/c21-15-9-11(2-8-17(27)28)1-7-16(15)29-10-14-18(12-3-5-13(22)6-4-12)26-30-19(14)20(23,24)25/h1,3-7,9H,2,8,10H2,(H,27,28)
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n/an/an/an/a 31n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 m...


ACS Med Chem Lett 8: 947-952 (2017)

More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207059
PNG
(CHEMBL3932664)
Show SMILES COc1cc(OC2CC2)cc(c1F)-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1/C22H23FN4O3/c1-28-20-12-17(29-15-5-6-15)11-18(22(20)23)13-3-8-19-14(10-13)2-4-16(30-19)7-9-21-24-26-27-25-21/h3,8,10-12,15-16H,2,4-7,9H2,1H3,(H,24,25,26,27)/t16-/s2
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n/an/an/an/a 32n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207065
PNG
(CHEMBL3971308)
Show SMILES OC(=O)[C@@H]1C[C@H]1[C@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1/C20H16F4O4/c21-16-4-3-12(28-20(22,23)24)8-13(16)10-1-5-17-11(7-10)2-6-18(27-17)14-9-15(14)19(25)26/h1,3-5,7-8,14-15,18H,2,6,9H2,(H,25,26)/t14-,15-,18-/s2
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n/an/an/an/a 33n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM50278672
PNG
(CHEMBL4161536)
Show SMILES CCc1ccc(cc1)-c1nsc(c1COc1c(F)cc(CCC(O)=O)cc1F)C(F)(F)F
Show InChI InChI=1S/C22H18F5NO3S/c1-2-12-3-6-14(7-4-12)19-15(21(32-28-19)22(25,26)27)11-31-20-16(23)9-13(10-17(20)24)5-8-18(29)30/h3-4,6-7,9-10H,2,5,8,11H2,1H3,(H,29,30)
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n/an/an/an/a 34n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 m...


ACS Med Chem Lett 8: 947-952 (2017)

More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207061
PNG
(CHEMBL3980898)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1/C22H23F2NO5/c1-28-15-9-16(10-15)30-19-11-17(23)21(24)22(25-19)13-3-6-18-12(8-13)2-4-14(29-18)5-7-20(26)27/h3,6,8,11,14-16H,2,4-5,7,9-10H2,1H3,(H,26,27)/t14-,15-,16-/s2
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n/an/an/an/a 35n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207064
PNG
(CHEMBL3943315)
Show SMILES COc1cc(Oc2ncc(C)s2)cc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1/C23H22FNO5S/c1-13-12-25-23(31-13)30-17-10-18(22(24)20(11-17)28-2)14-4-7-19-15(9-14)3-5-16(29-19)6-8-21(26)27/h4,7,9-12,16H,3,5-6,8H2,1-2H3,(H,26,27)/t16-/s2
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n/an/an/an/a 37n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50196402
PNG
(CHEMBL3910333)
Show SMILES Clc1cc(Oc2ccccn2)cc(c1)N1Cc2ccccc2S1(=O)=O
Show InChI InChI=1S/C18H13ClN2O3S/c19-14-9-15(11-16(10-14)24-18-7-3-4-8-20-18)21-12-13-5-1-2-6-17(13)25(21,22)23/h1-11H,12H2
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n/an/an/an/a 39n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay


J Med Chem 59: 8868-8878 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00685
BindingDB Entry DOI: 10.7270/Q2C53NS2
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM50232532
PNG
(CHEMBL4103243)
Show SMILES Cc1cc(COc2ccc(CCC(O)=O)cc2C)cc(Oc2ccccc2)c1
Show InChI InChI=1S/C24H24O4/c1-17-12-20(15-22(13-17)28-21-6-4-3-5-7-21)16-27-23-10-8-19(14-18(23)2)9-11-24(25)26/h3-8,10,12-15H,9,11,16H2,1-2H3,(H,25,26)
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n/an/an/an/a 40n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLI...


Bioorg Med Chem Lett 27: 1278-1283 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.034
BindingDB Entry DOI: 10.7270/Q2ZK5JWB
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207052
PNG
(CHEMBL3909773)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)cc(Cl)c1F
Show InChI InChI=1/C22H22ClFO4/c23-19-12-17(27-15-2-1-3-15)11-18(22(19)24)13-5-8-20-14(10-13)4-6-16(28-20)7-9-21(25)26/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,25,26)/t16-/s2
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n/an/an/an/a 40n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50196402
PNG
(CHEMBL3910333)
Show SMILES Clc1cc(Oc2ccccn2)cc(c1)N1Cc2ccccc2S1(=O)=O
Show InChI InChI=1S/C18H13ClN2O3S/c19-14-9-15(11-16(10-14)24-18-7-3-4-8-20-18)21-12-13-5-1-2-6-17(13)25(21,22)23/h1-11H,12H2
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n/an/an/an/a 40n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interacti...


J Med Chem 59: 8868-8878 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00685
BindingDB Entry DOI: 10.7270/Q2C53NS2
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM50232532
PNG
(CHEMBL4103243)
Show SMILES Cc1cc(COc2ccc(CCC(O)=O)cc2C)cc(Oc2ccccc2)c1
Show InChI InChI=1S/C24H24O4/c1-17-12-20(15-22(13-17)28-21-6-4-3-5-7-21)16-27-23-10-8-19(14-18(23)2)9-11-24(25)26/h3-8,10,12-15H,9,11,16H2,1-2H3,(H,25,26)
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n/an/an/an/a 40n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLI...


Bioorg Med Chem Lett 27: 1278-1283 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.034
BindingDB Entry DOI: 10.7270/Q2ZK5JWB
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207067
PNG
(CHEMBL3941726)
Show SMILES OC(=O)CC[C@@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1/C19H16F4O4/c20-16-6-4-14(27-19(21,22)23)10-15(16)11-2-7-17-12(9-11)1-3-13(26-17)5-8-18(24)25/h2,4,6-7,9-10,13H,1,3,5,8H2,(H,24,25)/t13-/s2
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n/an/an/an/a 42n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM50278673
PNG
(CHEMBL4165366)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(nsc2C(F)(F)F)-c2ccc(Cl)cc2F)c(F)c1
Show InChI InChI=1S/C20H12ClF6NO3S/c21-10-2-3-11(13(22)7-10)17-12(19(32-28-17)20(25,26)27)8-31-18-14(23)5-9(6-15(18)24)1-4-16(29)30/h2-3,5-7H,1,4,8H2,(H,29,30)
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n/an/an/an/a 42n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 m...


ACS Med Chem Lett 8: 947-952 (2017)

More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207054
PNG
(CHEMBL3907996)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(OC)c(F)c(c1)-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1/C24H27FN4O4/c1-30-17-10-18(11-17)32-19-12-20(24(25)22(13-19)31-2)14-4-7-21-15(9-14)3-5-16(33-21)6-8-23-26-28-29-27-23/h4,7,9,12-13,16-18H,3,5-6,8,10-11H2,1-2H3,(H,26,27,28,29)/t16-,17-,18-/s2
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n/an/an/an/a 43n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50420167
PNG
(CHEMBL2058533)
Show SMILES Cc1ccc(cc1)-c1ccc(F)cc1COc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C23H21FO3/c1-16-2-7-18(8-3-16)22-12-9-20(24)14-19(22)15-27-21-10-4-17(5-11-21)6-13-23(25)26/h2-5,7-12,14H,6,13,15H2,1H3,(H,25,26)
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n/an/an/an/a 43.6n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay


J Med Chem 55: 4511-5 (2012)


Article DOI: 10.1021/jm300215x
BindingDB Entry DOI: 10.7270/Q21Z45P4
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207069
PNG
(CHEMBL3959068)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(c1)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1/C24H24F2O5/c1-29-14-7-15(8-14)30-16-9-17(23(26)20(25)10-16)12-2-4-21-13(6-12)3-5-22(31-21)18-11-19(18)24(27)28/h2,4,6,9-10,14-15,18-19,22H,3,5,7-8,11H2,1H3,(H,27,28)/t14-,15-,18-,19-,22-/s2
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n/an/an/an/a 45n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50232515
PNG
(CHEMBL4084333)
Show SMILES Cc1ccc(Br)c(COc2ccc(CCC(O)=O)cc2C)c1
Show InChI InChI=1S/C18H19BrO3/c1-12-3-6-16(19)15(9-12)11-22-17-7-4-14(10-13(17)2)5-8-18(20)21/h3-4,6-7,9-10H,5,8,11H2,1-2H3,(H,20,21)
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n/an/an/an/a 50n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLI...


Bioorg Med Chem Lett 27: 1278-1283 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.034
BindingDB Entry DOI: 10.7270/Q2ZK5JWB
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM50278678
PNG
(CHEMBL4172136)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(nsc2C(F)(F)F)-c2ccc(cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H13F8NO3S/c22-14-7-10(1-6-16(31)32)8-15(23)18(14)33-9-13-17(30-34-19(13)21(27,28)29)11-2-4-12(5-3-11)20(24,25)26/h2-5,7-8H,1,6,9H2,(H,31,32)
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n/an/an/an/a 51n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme co...


ACS Med Chem Lett 8: 947-952 (2017)

More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))
BDBM50207059
PNG
(CHEMBL3932664)
Show SMILES COc1cc(OC2CC2)cc(c1F)-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1/C22H23FN4O3/c1-28-20-12-17(29-15-5-6-15)11-18(22(20)23)13-3-8-19-14(10-13)2-4-16(30-19)7-9-21-24-26-27-25-21/h3,8,10-12,15-16H,2,4-7,9H2,1H3,(H,24,25,26,27)/t16-/s2
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n/an/an/an/a 51n/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM50278710
PNG
(CHEMBL4159180)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(nsc2C(F)(F)F)-c2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C20H13ClF5NO3S/c21-12-4-2-11(3-5-12)17-13(19(31-27-17)20(24,25)26)9-30-18-14(22)7-10(8-15(18)23)1-6-16(28)29/h2-5,7-8H,1,6,9H2,(H,28,29)
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n/an/an/an/a 51n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 m...


ACS Med Chem Lett 8: 947-952 (2017)

More data for this
Ligand-Target Pair
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