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Compile Data Set for Download or QSAR

Found 911 hits Enz. Inhib. hit(s) with Target = 'G-protein coupled receptor 35'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM38549
PNG
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Show SMILES OC(=O)c1cc2ccccc2c(Cc2c(O)c(cc3ccccc23)C(O)=O)c1O
Show InChI InChI=1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29)
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n/an/an/an/a 2n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay


J Med Chem 60: 362-372 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM38549
PNG
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Show SMILES OC(=O)c1cc2ccccc2c(Cc2c(O)c(cc3ccccc23)C(O)=O)c1O
Show InChI InChI=1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29)
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n/an/an/an/a 2.10n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 by DMR assay


J Med Chem 56: 7084-99 (2013)

Checked by Author
Article DOI: 10.1021/jm4009373
BindingDB Entry DOI: 10.7270/Q2G16280
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436010
PNG
(CHEMBL2392141)
Show SMILES OC(=O)c1ccc(\C=C2/S\C(NC2=O)=N/c2ccccc2F)cc1
Show InChI InChI=1S/C17H11FN2O3S/c18-12-3-1-2-4-13(12)19-17-20-15(21)14(24-17)9-10-5-7-11(8-6-10)16(22)23/h1-9H,(H,22,23)(H,19,20,21)/b14-9-
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n/an/an/an/a 3.20n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 by Ca+2 release assay


J Med Chem 56: 7084-99 (2013)

Checked by Author
Article DOI: 10.1021/jm4009373
BindingDB Entry DOI: 10.7270/Q2G16280
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50440041
PNG
(CHEMBL2425820)
Show SMILES COc1ccc(cc1F)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(O)=O
Show InChI InChI=1S/C18H11BrFNO6/c1-26-14-3-2-8(4-11(14)20)17(23)21-12-6-9(19)5-10-13(22)7-15(18(24)25)27-16(10)12/h2-7H,1H3,(H,21,23)(H,24,25)
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n/an/an/an/a 4.40n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment as...


J Med Chem 56: 7084-99 (2013)

Checked by Author
Article DOI: 10.1021/jm4009373
BindingDB Entry DOI: 10.7270/Q2G16280
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50440042
PNG
(CHEMBL2425819)
Show SMILES COc1ccc(C(=O)Nc2cc(Br)cc3c2oc(cc3=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C18H11BrFNO6/c1-26-9-2-3-10(12(20)6-9)17(23)21-13-5-8(19)4-11-14(22)7-15(18(24)25)27-16(11)13/h2-7H,1H3,(H,21,23)(H,24,25)
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n/an/an/an/a 4.5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment as...


J Med Chem 56: 7084-99 (2013)

Checked by Author
Article DOI: 10.1021/jm4009373
BindingDB Entry DOI: 10.7270/Q2G16280
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50440040
PNG
(CHEMBL2425821)
Show SMILES COc1cc(F)c(C(=O)Nc2cc(Br)cc3c2oc(cc3=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C18H10BrF2NO6/c1-27-8-4-10(20)15(11(21)5-8)17(24)22-12-3-7(19)2-9-13(23)6-14(18(25)26)28-16(9)12/h2-6H,1H3,(H,22,24)(H,25,26)
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n/an/an/an/a 5.5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment as...


J Med Chem 56: 7084-99 (2013)

Checked by Author
Article DOI: 10.1021/jm4009373
BindingDB Entry DOI: 10.7270/Q2G16280
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436006
PNG
(CHEMBL2392171)
Show SMILES OC(=O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1
Show InChI InChI=1S/C17H8BrCl2NO5/c18-7-3-10-13(22)6-14(17(24)25)26-15(10)12(4-7)21-16(23)9-2-1-8(19)5-11(9)20/h1-6H,(H,21,23)(H,24,25)
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n/an/an/an/a 5.54n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment as...


J Med Chem 56: 7084-99 (2013)

Checked by Author
Article DOI: 10.1021/jm4009373
BindingDB Entry DOI: 10.7270/Q2G16280
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50259839
PNG
(CHEMBL4100677)
Show SMILES Oc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+]([O-])=O
Show InChI InChI=1S/C10H4BrN5O5/c11-5-2-3-1-4(9-12-14-15-13-9)10(18)21-8(3)6(7(5)17)16(19)20/h1-2,17H,(H,12,13,14,15)
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n/an/an/an/a 5.80n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay


J Med Chem 60: 362-372 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50259839
PNG
(CHEMBL4100677)
Show SMILES Oc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+]([O-])=O
Show InChI InChI=1S/C10H4BrN5O5/c11-5-2-3-1-4(9-12-14-15-13-9)10(18)21-8(3)6(7(5)17)16(19)20/h1-2,17H,(H,12,13,14,15)
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Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay


J Med Chem 60: 362-372 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50440043
PNG
(CHEMBL2425824)
Show SMILES COc1ccc(C(=O)Nc2cc(Cl)cc3c2oc(cc3=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C18H11ClFNO6/c1-26-9-2-3-10(12(20)6-9)17(23)21-13-5-8(19)4-11-14(22)7-15(18(24)25)27-16(11)13/h2-7H,1H3,(H,21,23)(H,24,25)
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n/an/an/an/a 6.10n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment as...


J Med Chem 56: 7084-99 (2013)

Checked by Author
Article DOI: 10.1021/jm4009373
BindingDB Entry DOI: 10.7270/Q2G16280
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436000
PNG
(CHEMBL2392179)
Show SMILES COc1ccc(C(=O)Nc2cc(Br)cc3c2oc(cc3=O)C(O)=O)c(Cl)c1
Show InChI InChI=1S/C18H11BrClNO6/c1-26-9-2-3-10(12(20)6-9)17(23)21-13-5-8(19)4-11-14(22)7-15(18(24)25)27-16(11)13/h2-7H,1H3,(H,21,23)(H,24,25)
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n/an/an/an/a 11n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436000
PNG
(CHEMBL2392179)
Show SMILES COc1ccc(C(=O)Nc2cc(Br)cc3c2oc(cc3=O)C(O)=O)c(Cl)c1
Show InChI InChI=1S/C18H11BrClNO6/c1-26-9-2-3-10(12(20)6-9)17(23)21-13-5-8(19)4-11-14(22)7-15(18(24)25)27-16(11)13/h2-7H,1H3,(H,21,23)(H,24,25)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436000
PNG
(CHEMBL2392179)
Show SMILES COc1ccc(C(=O)Nc2cc(Br)cc3c2oc(cc3=O)C(O)=O)c(Cl)c1
Show InChI InChI=1S/C18H11BrClNO6/c1-26-9-2-3-10(12(20)6-9)17(23)21-13-5-8(19)4-11-14(22)7-15(18(24)25)27-16(11)13/h2-7H,1H3,(H,21,23)(H,24,25)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment as...


J Med Chem 56: 7084-99 (2013)

Checked by Author
Article DOI: 10.1021/jm4009373
BindingDB Entry DOI: 10.7270/Q2G16280
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436001
PNG
(CHEMBL2392174 | CHEMBL2425818)
Show SMILES COc1ccc(cc1)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(O)=O
Show InChI InChI=1S/C18H12BrNO6/c1-25-11-4-2-9(3-5-11)17(22)20-13-7-10(19)6-12-14(21)8-15(18(23)24)26-16(12)13/h2-8H,1H3,(H,20,22)(H,23,24)
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n/an/an/an/a 12n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436001
PNG
(CHEMBL2392174 | CHEMBL2425818)
Show SMILES COc1ccc(cc1)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(O)=O
Show InChI InChI=1S/C18H12BrNO6/c1-25-11-4-2-9(3-5-11)17(22)20-13-7-10(19)6-12-14(21)8-15(18(23)24)26-16(12)13/h2-8H,1H3,(H,20,22)(H,23,24)
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Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay


J Med Chem 60: 362-372 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436001
PNG
(CHEMBL2392174 | CHEMBL2425818)
Show SMILES COc1ccc(cc1)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(O)=O
Show InChI InChI=1S/C18H12BrNO6/c1-25-11-4-2-9(3-5-11)17(22)20-13-7-10(19)6-12-14(21)8-15(18(23)24)26-16(12)13/h2-8H,1H3,(H,20,22)(H,23,24)
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n/an/an/an/a 12n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50259887
PNG
(CHEMBL3277775)
Show SMILES OC(=O)c1cc(=O)c2c(ccc3c2[nH]c(cc3=O)C(O)=O)[nH]1
Show InChI InChI=1S/C14H8N2O6/c17-9-3-8(14(21)22)16-12-5(9)1-2-6-11(12)10(18)4-7(15-6)13(19)20/h1-4H,(H,15,18)(H,16,17)(H,19,20)(H,21,22)
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Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay


J Med Chem 60: 362-372 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50259842
PNG
(CHEMBL4079816)
Show SMILES Oc1c(cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C10H4N6O7/c17-7-5(15(19)20)2-3-1-4(9-11-13-14-12-9)10(18)23-8(3)6(7)16(21)22/h1-2,17H,(H,11,12,13,14)
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Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay


J Med Chem 60: 362-372 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50259842
PNG
(CHEMBL4079816)
Show SMILES Oc1c(cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C10H4N6O7/c17-7-5(15(19)20)2-3-1-4(9-11-13-14-12-9)10(18)23-8(3)6(7)16(21)22/h1-2,17H,(H,11,12,13,14)
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Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay


J Med Chem 60: 362-372 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436000
PNG
(CHEMBL2392179)
Show SMILES COc1ccc(C(=O)Nc2cc(Br)cc3c2oc(cc3=O)C(O)=O)c(Cl)c1
Show InChI InChI=1S/C18H11BrClNO6/c1-26-9-2-3-10(12(20)6-9)17(23)21-13-5-8(19)4-11-14(22)7-15(18(24)25)27-16(11)13/h2-7H,1H3,(H,21,23)(H,24,25)
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n/an/an/an/a 15n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35b expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase report...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436003
PNG
(CHEMBL2392172)
Show SMILES OC(=O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)c(Cl)c3)c2o1
Show InChI InChI=1S/C17H8BrCl2NO5/c18-8-4-9-13(22)6-14(17(24)25)26-15(9)12(5-8)21-16(23)7-1-2-10(19)11(20)3-7/h1-6H,(H,21,23)(H,24,25)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436003
PNG
(CHEMBL2392172)
Show SMILES OC(=O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)c(Cl)c3)c2o1
Show InChI InChI=1S/C17H8BrCl2NO5/c18-8-4-9-13(22)6-14(17(24)25)26-15(9)12(5-8)21-16(23)7-1-2-10(19)11(20)3-7/h1-6H,(H,21,23)(H,24,25)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436006
PNG
(CHEMBL2392171)
Show SMILES OC(=O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1
Show InChI InChI=1S/C17H8BrCl2NO5/c18-7-3-10-13(22)6-14(17(24)25)26-15(10)12(4-7)21-16(23)9-2-1-8(19)5-11(9)20/h1-6H,(H,21,23)(H,24,25)
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n/an/an/an/a 16n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436006
PNG
(CHEMBL2392171)
Show SMILES OC(=O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1
Show InChI InChI=1S/C17H8BrCl2NO5/c18-7-3-10-13(22)6-14(17(24)25)26-15(10)12(4-7)21-16(23)9-2-1-8(19)5-11(9)20/h1-6H,(H,21,23)(H,24,25)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50385230
PNG
(CHEMBL2037456)
Show SMILES OC(=O)c1sc2c(Br)c(Br)sc2c1O
Show InChI InChI=1S/C7H2Br2O3S2/c8-1-3-4(14-6(1)9)2(10)5(13-3)7(11)12/h10H,(H,11,12)
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n/an/an/an/a 16n/an/an/an/a



Corning Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assay


Bioorg Med Chem Lett 22: 4148-52 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.057
BindingDB Entry DOI: 10.7270/Q2C53MW0
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436008
PNG
(CHEMBL2392160)
Show SMILES OC(=O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1
Show InChI InChI=1S/C17H8Cl2FNO5/c18-7-1-2-9(11(19)3-7)16(23)21-12-5-8(20)4-10-13(22)6-14(17(24)25)26-15(10)12/h1-6H,(H,21,23)(H,24,25)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436007
PNG
(CHEMBL2392167)
Show SMILES COc1ccc(cc1)C(=O)Nc1cc(Cl)cc2c1oc(cc2=O)C(O)=O
Show InChI InChI=1S/C18H12ClNO6/c1-25-11-4-2-9(3-5-11)17(22)20-13-7-10(19)6-12-14(21)8-15(18(23)24)26-16(12)13/h2-8H,1H3,(H,20,22)(H,23,24)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436007
PNG
(CHEMBL2392167)
Show SMILES COc1ccc(cc1)C(=O)Nc1cc(Cl)cc2c1oc(cc2=O)C(O)=O
Show InChI InChI=1S/C18H12ClNO6/c1-25-11-4-2-9(3-5-11)17(22)20-13-7-10(19)6-12-14(21)8-15(18(23)24)26-16(12)13/h2-8H,1H3,(H,20,22)(H,23,24)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436007
PNG
(CHEMBL2392167)
Show SMILES COc1ccc(cc1)C(=O)Nc1cc(Cl)cc2c1oc(cc2=O)C(O)=O
Show InChI InChI=1S/C18H12ClNO6/c1-25-11-4-2-9(3-5-11)17(22)20-13-7-10(19)6-12-14(21)8-15(18(23)24)26-16(12)13/h2-8H,1H3,(H,20,22)(H,23,24)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment as...


J Med Chem 56: 7084-99 (2013)

Checked by Author
Article DOI: 10.1021/jm4009373
BindingDB Entry DOI: 10.7270/Q2G16280
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436008
PNG
(CHEMBL2392160)
Show SMILES OC(=O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1
Show InChI InChI=1S/C17H8Cl2FNO5/c18-7-1-2-9(11(19)3-7)16(23)21-12-5-8(20)4-10-13(22)6-14(17(24)25)26-15(10)12/h1-6H,(H,21,23)(H,24,25)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436008
PNG
(CHEMBL2392160)
Show SMILES OC(=O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1
Show InChI InChI=1S/C17H8Cl2FNO5/c18-7-1-2-9(11(19)3-7)16(23)21-12-5-8(20)4-10-13(22)6-14(17(24)25)26-15(10)12/h1-6H,(H,21,23)(H,24,25)
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n/an/an/an/a 21n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35b expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase report...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436001
PNG
(CHEMBL2392174 | CHEMBL2425818)
Show SMILES COc1ccc(cc1)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(O)=O
Show InChI InChI=1S/C18H12BrNO6/c1-25-11-4-2-9(3-5-11)17(22)20-13-7-10(19)6-12-14(21)8-15(18(23)24)26-16(12)13/h2-8H,1H3,(H,20,22)(H,23,24)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35b expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase report...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436003
PNG
(CHEMBL2392172)
Show SMILES OC(=O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)c(Cl)c3)c2o1
Show InChI InChI=1S/C17H8BrCl2NO5/c18-8-4-9-13(22)6-14(17(24)25)26-15(9)12(5-8)21-16(23)7-1-2-10(19)11(20)3-7/h1-6H,(H,21,23)(H,24,25)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment as...


J Med Chem 56: 7084-99 (2013)

Checked by Author
Article DOI: 10.1021/jm4009373
BindingDB Entry DOI: 10.7270/Q2G16280
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436012
PNG
(CHEMBL2392170)
Show SMILES OC(=O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3)c2o1
Show InChI InChI=1S/C17H9BrClNO5/c18-9-5-11-13(21)7-14(17(23)24)25-15(11)12(6-9)20-16(22)8-1-3-10(19)4-2-8/h1-7H,(H,20,22)(H,23,24)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436012
PNG
(CHEMBL2392170)
Show SMILES OC(=O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3)c2o1
Show InChI InChI=1S/C17H9BrClNO5/c18-9-5-11-13(21)7-14(17(23)24)25-15(11)12(6-9)20-16(22)8-1-3-10(19)4-2-8/h1-7H,(H,20,22)(H,23,24)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment as...


J Med Chem 56: 7084-99 (2013)

Checked by Author
Article DOI: 10.1021/jm4009373
BindingDB Entry DOI: 10.7270/Q2G16280
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436010
PNG
(CHEMBL2392141)
Show SMILES OC(=O)c1ccc(\C=C2/S\C(NC2=O)=N/c2ccccc2F)cc1
Show InChI InChI=1S/C17H11FN2O3S/c18-12-3-1-2-4-13(12)19-17-20-15(21)14(24-17)9-10-5-7-11(8-6-10)16(22)23/h1-9H,(H,22,23)(H,19,20,21)/b14-9-
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50440038
PNG
(CHEMBL2425823)
Show SMILES COc1ccc(cc1)C(=O)Nc1cc(OC)cc2c1oc(cc2=O)C(O)=O
Show InChI InChI=1S/C19H15NO7/c1-25-11-5-3-10(4-6-11)18(22)20-14-8-12(26-2)7-13-15(21)9-16(19(23)24)27-17(13)14/h3-9H,1-2H3,(H,20,22)(H,23,24)
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n/an/an/an/a 26n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment as...


J Med Chem 56: 7084-99 (2013)

Checked by Author
Article DOI: 10.1021/jm4009373
BindingDB Entry DOI: 10.7270/Q2G16280
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436010
PNG
(CHEMBL2392141)
Show SMILES OC(=O)c1ccc(\C=C2/S\C(NC2=O)=N/c2ccccc2F)cc1
Show InChI InChI=1S/C17H11FN2O3S/c18-12-3-1-2-4-13(12)19-17-20-15(21)14(24-17)9-10-5-7-11(8-6-10)16(22)23/h1-9H,(H,22,23)(H,19,20,21)/b14-9-
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436003
PNG
(CHEMBL2392172)
Show SMILES OC(=O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)c(Cl)c3)c2o1
Show InChI InChI=1S/C17H8BrCl2NO5/c18-8-4-9-13(22)6-14(17(24)25)26-15(9)12(5-8)21-16(23)7-1-2-10(19)11(20)3-7/h1-6H,(H,21,23)(H,24,25)
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n/an/an/an/a 27n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35b expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase report...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436007
PNG
(CHEMBL2392167)
Show SMILES COc1ccc(cc1)C(=O)Nc1cc(Cl)cc2c1oc(cc2=O)C(O)=O
Show InChI InChI=1S/C18H12ClNO6/c1-25-11-4-2-9(3-5-11)17(22)20-13-7-10(19)6-12-14(21)8-15(18(23)24)26-16(12)13/h2-8H,1H3,(H,20,22)(H,23,24)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35b expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase report...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50435998
PNG
(CHEMBL2392183)
Show SMILES COc1ccc(cn1)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(O)=O
Show InChI InChI=1S/C17H11BrN2O6/c1-25-14-3-2-8(7-19-14)16(22)20-11-5-9(18)4-10-12(21)6-13(17(23)24)26-15(10)11/h2-7H,1H3,(H,20,22)(H,23,24)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50435998
PNG
(CHEMBL2392183)
Show SMILES COc1ccc(cn1)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(O)=O
Show InChI InChI=1S/C17H11BrN2O6/c1-25-14-3-2-8(7-19-14)16(22)20-11-5-9(18)4-10-12(21)6-13(17(23)24)26-15(10)11/h2-7H,1H3,(H,20,22)(H,23,24)
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50357187
PNG
(CHEMBL1914576)
Show SMILES CC1=C(C#N)C(OC1(C)c1ccc(Cl)c(Cl)c1)=C(C#N)C#N
Show InChI InChI=1/C16H9Cl2N3O/c1-9-12(8-21)15(10(6-19)7-20)22-16(9,2)11-3-4-13(17)14(18)5-11/h3-5H,1-2H3
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Corning Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells after 1 hr by dynamic mass redistribution assay


J Med Chem 54: 7385-96 (2011)


Article DOI: 10.1021/jm200999f
BindingDB Entry DOI: 10.7270/Q2XG9RKZ
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50357187
PNG
(CHEMBL1914576)
Show SMILES CC1=C(C#N)C(OC1(C)c1ccc(Cl)c(Cl)c1)=C(C#N)C#N
Show InChI InChI=1/C16H9Cl2N3O/c1-9-12(8-21)15(10(6-19)7-20)22-16(9,2)11-3-4-13(17)14(18)5-11/h3-5H,1-2H3
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Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay


J Med Chem 60: 362-372 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436006
PNG
(CHEMBL2392171)
Show SMILES OC(=O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1
Show InChI InChI=1S/C17H8BrCl2NO5/c18-7-3-10-13(22)6-14(17(24)25)26-15(10)12(4-7)21-16(23)9-2-1-8(19)5-11(9)20/h1-6H,(H,21,23)(H,24,25)
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n/an/an/an/a 35n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35b expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase report...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50440039
PNG
(CHEMBL2425822)
Show SMILES COc1ccc(cc1)C(=O)Nc1cc(C)cc2c1oc(cc2=O)C(O)=O
Show InChI InChI=1S/C19H15NO6/c1-10-7-13-15(21)9-16(19(23)24)26-17(13)14(8-10)20-18(22)11-3-5-12(25-2)6-4-11/h3-9H,1-2H3,(H,20,22)(H,23,24)
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n/an/an/an/a 38n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment as...


J Med Chem 56: 7084-99 (2013)

Checked by Author
Article DOI: 10.1021/jm4009373
BindingDB Entry DOI: 10.7270/Q2G16280
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50436012
PNG
(CHEMBL2392170)
Show SMILES OC(=O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3)c2o1
Show InChI InChI=1S/C17H9BrClNO5/c18-9-5-11-13(21)7-14(17(23)24)25-15(11)12(6-9)20-16(22)8-1-3-10(19)4-2-8/h1-7H,(H,20,22)(H,23,24)
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n/an/an/an/a 41n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35b expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase report...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM38549
PNG
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Show SMILES OC(=O)c1cc2ccccc2c(Cc2c(O)c(cc3ccccc23)C(O)=O)c1O
Show InChI InChI=1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29)
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n/an/an/an/a 50n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...


J Med Chem 56: 5182-97 (2013)


Article DOI: 10.1021/jm400587g
BindingDB Entry DOI: 10.7270/Q20C4X5B
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50259845
PNG
(CHEMBL4082281)
Show SMILES OC(=O)c1cc2cc(Br)c(O)c([N+]([O-])=O)c2oc1=O
Show InChI InChI=1S/C10H4BrNO7/c11-5-2-3-1-4(9(14)15)10(16)19-8(3)6(7(5)13)12(17)18/h1-2,13H,(H,14,15)
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n/an/an/an/a 51n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay


J Med Chem 60: 362-372 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))
BDBM50259845
PNG
(CHEMBL4082281)
Show SMILES OC(=O)c1cc2cc(Br)c(O)c([N+]([O-])=O)c2oc1=O
Show InChI InChI=1S/C10H4BrNO7/c11-5-2-3-1-4(9(14)15)10(16)19-8(3)6(7(5)13)12(17)18/h1-2,13H,(H,14,15)
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n/an/an/an/a 51n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay


J Med Chem 60: 362-372 (2017)

More data for this
Ligand-Target Pair
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