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Compile Data Set for Download or QSAR

Found 116 hits Enz. Inhib. hit(s) with Target = 'GABA receptor alpha-2/beta-2/gamma-2 subunit'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164567
PNG
(2-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-1H-imid...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H13BrCl2N2O2/c1-2-25-18(24)15-10-23(16-8-7-13(20)9-14(16)21)17(22-15)11-3-5-12(19)6-4-11/h3-10H,2H2,1H3
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n/an/an/an/a 190n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50052792
PNG
(CHEBI:7035 | MUSCIMOL | Muscimol)
Show SMILES NCc1cc(O)no1
Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
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n/an/an/an/a 407n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50052792
PNG
(CHEBI:7035 | MUSCIMOL | Muscimol)
Show SMILES NCc1cc(O)no1
Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
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n/an/an/an/a 410n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164569
PNG
(1-(2,4-Dichloro-phenyl)-2-(4-iodo-phenyl)-1H-imida...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(I)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H13Cl2IN2O2/c1-2-25-18(24)15-10-23(16-8-5-12(19)9-14(16)20)17(22-15)11-3-6-13(21)7-4-11/h3-10H,2H2,1H3
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n/an/an/an/a 450n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164557
PNG
(2-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-imi...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H13Cl3N2O2/c1-2-25-18(24)15-10-23(16-8-7-13(20)9-14(16)21)17(22-15)11-3-5-12(19)6-4-11/h3-10H,2H2,1H3
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n/an/an/an/a 600n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM24183
PNG
(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Show SMILES NCCCC(O)=O
Show InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
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n/an/an/an/a 650n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM24183
PNG
(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Show SMILES NCCCC(O)=O
Show InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
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n/an/an/an/a 661n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50052799
PNG
(CHEMBL3322882)
Show SMILES NC1=NCC(CC1)C(O)=O
Show InChI InChI=1S/C6H10N2O2/c7-5-2-1-4(3-8-5)6(9)10/h4H,1-3H2,(H2,7,8)(H,9,10)
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n/an/an/an/a 820n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50052799
PNG
(CHEMBL3322882)
Show SMILES NC1=NCC(CC1)C(O)=O
Show InChI InChI=1S/C6H10N2O2/c7-5-2-1-4(3-8-5)6(9)10/h4H,1-3H2,(H2,7,8)(H,9,10)
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n/an/an/an/a 832n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164579
PNG
(1-(2,4-Dichloro-phenyl)-2-p-tolyl-1H-imidazole-4-c...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(C)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H16Cl2N2O2/c1-3-25-19(24)16-11-23(17-9-8-14(20)10-15(17)21)18(22-16)13-6-4-12(2)5-7-13/h4-11H,3H2,1-2H3
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n/an/an/an/a 1.00E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164562
PNG
(CHEMBL192127 | [2-(4-Chloro-phenyl)-1-(2,4-dichlor...)
Show SMILES CN1CCN(CC1)C(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H19Cl3N4O/c1-26-8-10-27(11-9-26)21(29)18-13-28(19-7-6-16(23)12-17(19)24)20(25-18)14-2-4-15(22)5-3-14/h2-7,12-13H,8-11H2,1H3
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n/an/an/an/a 1.30E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164558
PNG
(1,2-Bis-(4-chloro-phenyl)-1H-imidazole-4-carboxyli...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H14Cl2N2O2/c1-2-24-18(23)16-11-22(15-9-7-14(20)8-10-15)17(21-16)12-3-5-13(19)6-4-12/h3-11H,2H2,1H3
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n/an/an/an/a 1.50E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164576
PNG
(2-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-1H-imid...)
Show SMILES CCCOC(=O)c1cn(c(n1)-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H15BrCl2N2O2/c1-2-9-26-19(25)16-11-24(17-8-7-14(21)10-15(17)22)18(23-16)12-3-5-13(20)6-4-12/h3-8,10-11H,2,9H2,1H3
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n/an/an/an/a 1.70E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164566
PNG
(1-(2,4-Dichloro-phenyl)-2-phenyl-1H-imidazole-4-ca...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccccc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H14Cl2N2O2/c1-2-24-18(23)15-11-22(16-9-8-13(19)10-14(16)20)17(21-15)12-6-4-3-5-7-12/h3-11H,2H2,1H3
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n/an/an/an/a 1.80E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164573
PNG
(1-(2,4-Dichloro-phenyl)-2-(4-methoxy-phenyl)-1H-im...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(OC)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H16Cl2N2O3/c1-3-26-19(24)16-11-23(17-9-6-13(20)10-15(17)21)18(22-16)12-4-7-14(25-2)8-5-12/h4-11H,3H2,1-2H3
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n/an/an/an/a 1.90E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164570
PNG
((3R,5S,8S,9S,10S,13S,14S,17S)-17-Acetyl-3-hydroxy-...)
Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C
Show InChI InChI=1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/m0/s1
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n/an/an/an/a 2.00E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164578
PNG
(2-(4-Chloro-phenyl)-1-(3,4-dichloro-phenyl)-1H-imi...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H13Cl3N2O2/c1-2-25-18(24)16-10-23(13-7-8-14(20)15(21)9-13)17(22-16)11-3-5-12(19)6-4-11/h3-10H,2H2,1H3
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n/an/an/an/a 2.30E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164577
PNG
(1-(2,4-Dichloro-phenyl)-2-(4-nitro-phenyl)-1H-imid...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(cc1)[N+]([O-])=O)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H13Cl2N3O4/c1-2-27-18(24)15-10-22(16-8-5-12(19)9-14(16)20)17(21-15)11-3-6-13(7-4-11)23(25)26/h3-10H,2H2,1H3
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n/an/an/an/a 2.40E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164575
PNG
(1-(3-Chloro-phenyl)-2-phenyl-1H-imidazole-4-carbox...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccccc1)-c1cccc(Cl)c1
Show InChI InChI=1S/C18H15ClN2O2/c1-2-23-18(22)16-12-21(15-10-6-9-14(19)11-15)17(20-16)13-7-4-3-5-8-13/h3-12H,2H2,1H3
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n/an/an/an/a 3.00E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164561
PNG
(1,2-Bis-(4-fluoro-phenyl)-1H-imidazole-4-carboxyli...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(F)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H14F2N2O2/c1-2-24-18(23)16-11-22(15-9-7-14(20)8-10-15)17(21-16)12-3-5-13(19)6-4-12/h3-11H,2H2,1H3
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n/an/an/an/a 3.10E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164574
PNG
(2-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-1H-imid...)
Show SMILES COC(=O)c1cn(c(n1)-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C17H11BrCl2N2O2/c1-24-17(23)14-9-22(15-7-6-12(19)8-13(15)20)16(21-14)10-2-4-11(18)5-3-10/h2-9H,1H3
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n/an/an/an/a 3.40E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50125935
PNG
((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)
Show SMILES CCOC(=O)c1cncn1[C@H](C)c1ccccc1
Show InChI InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
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n/an/an/an/a 3.50E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164559
PNG
(1-Phenyl-2-p-tolyl-1H-imidazole-4-carboxylic acid ...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(C)cc1)-c1ccccc1
Show InChI InChI=1S/C19H18N2O2/c1-3-23-19(22)17-13-21(16-7-5-4-6-8-16)18(20-17)15-11-9-14(2)10-12-15/h4-13H,3H2,1-2H3
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n/an/an/an/a 4.10E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164560
PNG
(2-(4-Chloro-phenyl)-1-phenyl-1H-imidazole-4-carbox...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccccc1
Show InChI InChI=1S/C18H15ClN2O2/c1-2-23-18(22)16-12-21(15-6-4-3-5-7-15)17(20-16)13-8-10-14(19)11-9-13/h3-12H,2H2,1H3
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n/an/an/an/a 4.20E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164564
PNG
(2-(4-Amino-phenyl)-1-(2,4-dichloro-phenyl)-1H-imid...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(N)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H15Cl2N3O2/c1-2-25-18(24)15-10-23(16-8-5-12(19)9-14(16)20)17(22-15)11-3-6-13(21)7-4-11/h3-10H,2,21H2,1H3
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n/an/an/an/a 4.30E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164563
PNG
(2-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-imi...)
Show SMILES CCN(CC)C(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C20H18Cl3N3O/c1-3-25(4-2)20(27)17-12-26(18-10-9-15(22)11-16(18)23)19(24-17)13-5-7-14(21)8-6-13/h5-12H,3-4H2,1-2H3
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n/an/an/an/a 4.40E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50032955
PNG
(1,2,3,6-Tetrahydro-pyridine-4-carboxylic acid | 1,...)
Show SMILES OC(=O)C1=CCNCC1
Show InChI InChI=1S/C6H9NO2/c8-6(9)5-1-3-7-4-2-5/h1,7H,2-4H2,(H,8,9)
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n/an/an/an/a 4.47E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50032955
PNG
(1,2,3,6-Tetrahydro-pyridine-4-carboxylic acid | 1,...)
Show SMILES OC(=O)C1=CCNCC1
Show InChI InChI=1S/C6H9NO2/c8-6(9)5-1-3-7-4-2-5/h1,7H,2-4H2,(H,8,9)
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n/an/an/an/a 4.50E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164565
PNG
(1,2-Diphenyl-1H-imidazole-4-carboxylic acid ethyl ...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C18H16N2O2/c1-2-22-18(21)16-13-20(15-11-7-4-8-12-15)17(19-16)14-9-5-3-6-10-14/h3-13H,2H2,1H3
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n/an/an/an/a 6.40E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164568
PNG
(2-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-imi...)
Show SMILES OC(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H9Cl3N2O2/c17-10-3-1-9(2-4-10)15-20-13(16(22)23)8-21(15)14-6-5-11(18)7-12(14)19/h1-8H,(H,22,23)
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n/an/an/an/a 8.70E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164572
PNG
(2-(4-Methoxy-phenyl)-1-phenyl-1H-imidazole-4-carbo...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(OC)cc1)-c1ccccc1
Show InChI InChI=1S/C19H18N2O3/c1-3-24-19(22)17-13-21(15-7-5-4-6-8-15)18(20-17)14-9-11-16(23-2)12-10-14/h4-13H,3H2,1-2H3
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n/an/an/an/a 9.10E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50052801
PNG
(CHEMBL3322886)
Show SMILES NC1=NCC(CN1)C(O)=O
Show InChI InChI=1S/C5H9N3O2/c6-5-7-1-3(2-8-5)4(9)10/h3H,1-2H2,(H,9,10)(H3,6,7,8)
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n/an/an/an/a 9.33E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50052801
PNG
(CHEMBL3322886)
Show SMILES NC1=NCC(CN1)C(O)=O
Show InChI InChI=1S/C5H9N3O2/c6-5-7-1-3(2-8-5)4(9)10/h3H,1-2H2,(H,9,10)(H3,6,7,8)
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n/an/an/an/a 9.40E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50058046
PNG
(CHEMBL526 | PROPOFOL | propofol)
Show SMILES CC(C)c1cccc(C(C)C)c1O
Show InChI InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
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n/an/an/an/a 1.12E+4n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50164571
PNG
(2-(4-Acetylamino-phenyl)-1-(2,4-dichloro-phenyl)-1...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(NC(C)=O)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C20H17Cl2N3O3/c1-3-28-20(27)17-11-25(18-9-6-14(21)10-16(18)22)19(24-17)13-4-7-15(8-5-13)23-12(2)26/h4-11H,3H2,1-2H3,(H,23,26)
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n/an/an/an/a 1.90E+4n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50000106
PNG
(4-CARBOXYPIPERIDINE | CHEMBL279998 | Piperidine-4-...)
Show SMILES OC(=O)C1CCNCC1
Show InChI InChI=1S/C6H11NO2/c8-6(9)5-1-3-7-4-2-5/h5,7H,1-4H2,(H,8,9)
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n/an/an/an/a 2.40E+4n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50000106
PNG
(4-CARBOXYPIPERIDINE | CHEMBL279998 | Piperidine-4-...)
Show SMILES OC(=O)C1CCNCC1
Show InChI InChI=1S/C6H11NO2/c8-6(9)5-1-3-7-4-2-5/h5,7H,1-4H2,(H,8,9)
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n/an/an/an/a 2.40E+4n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50055935
PNG
(5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidi...)
Show SMILES CCCC(C)C1(CC)C(=O)NC(=O)NC1=O
Show InChI InChI=1S/C11H18N2O3/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
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n/an/an/an/a 5.00E+4n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50060088
PNG
(2-(6-Chloro-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-N...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccccc1
Show InChI InChI=1S/C21H24ClN3O/c1-3-12-24(13-4-2)20(26)14-18-21(16-8-6-5-7-9-16)23-19-11-10-17(22)15-25(18)19/h5-11,15H,3-4,12-14H2,1-2H3
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n/an/an/an/a 1.30E+9n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Potentiation of GABA-evoked Cl- currents in Xenopus oocytes expressing human alpha-2-beta-2-gamma-2 subunits


J Med Chem 40: 3109-18 (1997)


Article DOI: 10.1021/jm970112+
BindingDB Entry DOI: 10.7270/Q2PN9699
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM26266
PNG
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Show SMILES CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
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n/an/an/an/a 1.80E+9n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Potentiation of GABA-evoked Cl- currents in Xenopus oocytes expressing human alpha-2-beta-2-gamma-2 subunits


J Med Chem 40: 3109-18 (1997)


Article DOI: 10.1021/jm970112+
BindingDB Entry DOI: 10.7270/Q2PN9699
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50060124
PNG
(2-[6-Chloro-2-(4-chloro-phenyl)-imidazo[1,2-a]pyri...)
Show SMILES Clc1ccc(cc1)-c1nc2ccc(Cl)cn2c1CC(=O)N1CCCC1
Show InChI InChI=1S/C19H17Cl2N3O/c20-14-5-3-13(4-6-14)19-16(11-18(25)23-9-1-2-10-23)24-12-15(21)7-8-17(24)22-19/h3-8,12H,1-2,9-11H2
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n/an/an/an/a 6.60E+9n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Potentiation of GABA-evoked Cl- currents in Xenopus oocytes expressing human alpha-2-beta-2-gamma-2 subunits


J Med Chem 40: 3109-18 (1997)


Article DOI: 10.1021/jm970112+
BindingDB Entry DOI: 10.7270/Q2PN9699
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM26267
PNG
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)
Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-]
Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3
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2.60n/an/an/an/an/an/an/an/a



University of Wisconsin-Milwaukee

Curated by ChEMBL


Assay Description
Binding affinity for human GABA-A receptor alpha-2-beta-2-gamma-2 expressed in L(tk-) cell membranes


J Med Chem 39: 1928-34 (1996)


Article DOI: 10.1021/jm950887n
BindingDB Entry DOI: 10.7270/Q2K35SR6
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50049737
PNG
(5-Methyl-6-oxo-8-propa-1,2-dienyl-5,6-dihydro-4H-2...)
Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(C=C=C)ccc-21
Show InChI InChI=1S/C18H17N3O3/c1-4-6-12-7-8-14-13(9-12)17(22)20(3)10-15-16(18(23)24-5-2)19-11-21(14)15/h6-9,11H,1,5,10H2,2-3H3
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7.20n/an/an/an/an/an/an/an/a



University of Wisconsin-Milwaukee

Curated by ChEMBL


Assay Description
Binding affinity for human GABA-A receptor alpha-2-beta-2-gamma-2 expressed in L(tk-) cell membranes


J Med Chem 39: 1928-34 (1996)


Article DOI: 10.1021/jm950887n
BindingDB Entry DOI: 10.7270/Q2K35SR6
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50044947
PNG
(8-Bromo-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tria...)
Show SMILES CN1Cc2c(ncn2-c2ccc(Br)cc2C1=O)C(=O)OC(C)(C)C
Show InChI InChI=1S/C17H18BrN3O3/c1-17(2,3)24-16(23)14-13-8-20(4)15(22)11-7-10(18)5-6-12(11)21(13)9-19-14/h5-7,9H,8H2,1-4H3
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11n/an/an/an/an/an/an/an/a



University of Wisconsin-Milwaukee

Curated by ChEMBL


Assay Description
Binding affinity for human GABA-A receptor alpha-2-beta-2-gamma-2 expressed in L(tk-) cell membranes


J Med Chem 39: 1928-34 (1996)


Article DOI: 10.1021/jm950887n
BindingDB Entry DOI: 10.7270/Q2K35SR6
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Rattus norvegicus (Rat))
BDBM50165326
PNG
(8-Chloro-2-phenyl-5H-3,3a,5,9b-tetraaza-cyclopenta...)
Show SMILES Clc1ccc2[nH]c(=O)n3nc(-c4ccccc4)c(=O)n3c2c1
Show InChI InChI=1S/C15H9ClN4O2/c16-10-6-7-11-12(8-10)19-14(21)13(9-4-2-1-3-5-9)18-20(19)15(22)17-11/h1-8H,(H,17,22)
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13.9n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha2-beta2-gamma2 expressed in HEK293 cells


J Med Chem 48: 2936-43 (2005)


Article DOI: 10.1021/jm0408722
BindingDB Entry DOI: 10.7270/Q2H994QV
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Rattus norvegicus (Rat))
BDBM50165325
PNG
(2-(4-Methoxy-phenyl)-5H-3,3a,5,9b-tetraaza-cyclope...)
Show SMILES COc1ccc(cc1)-c1nn2n(c3ccccc3[nH]c2=O)c1=O
Show InChI InChI=1S/C16H12N4O3/c1-23-11-8-6-10(7-9-11)14-15(21)19-13-5-3-2-4-12(13)17-16(22)20(19)18-14/h2-9H,1H3,(H,17,22)
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14.3n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha2-beta2-gamma2 expressed in HEK293 cells


J Med Chem 48: 2936-43 (2005)


Article DOI: 10.1021/jm0408722
BindingDB Entry DOI: 10.7270/Q2H994QV
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50214675
PNG
(4-cyclohexyl-1-(2,6-dichloro-4-(trifluoromethyl)ph...)
Show SMILES FC(F)(F)c1cc(Cl)c(c(Cl)c1)-n1cc(nn1)C1CCCCC1
Show InChI InChI=1S/C15H14Cl2F3N3/c16-11-6-10(15(18,19)20)7-12(17)14(11)23-8-13(21-22-23)9-4-2-1-3-5-9/h6-9H,1-5H2
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15n/an/an/an/an/an/an/an/a



Shimane University

Curated by ChEMBL


Assay Description
Displacement of [3H]EBOB from human recombinant GABA alpha-1-beta-2-gamma-2 receptor expressed in HEK293 cells


Bioorg Med Chem 15: 5090-104 (2007)


Article DOI: 10.1016/j.bmc.2007.05.039
BindingDB Entry DOI: 10.7270/Q2K64HS0
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50034839
PNG
(8-Chloro-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tri...)
Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(Cl)ccc-21
Show InChI InChI=1S/C15H14ClN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
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16.3n/an/an/an/an/an/an/an/a



University of Massachusetts

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant GABA alpha2beta2gamma2 receptor


Bioorg Med Chem 18: 7731-8 (2010)


Article DOI: 10.1016/j.bmc.2010.05.056
BindingDB Entry DOI: 10.7270/Q21R6QRB
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Rattus norvegicus (Rat))
BDBM50165329
PNG
(8-Chloro-2-(4-methoxy-phenyl)-5H-3,3a,5,9b-tetraaz...)
Show SMILES COc1ccc(cc1)-c1nn2n(c3cc(Cl)ccc3[nH]c2=O)c1=O
Show InChI InChI=1S/C16H11ClN4O3/c1-24-11-5-2-9(3-6-11)14-15(22)20-13-8-10(17)4-7-12(13)18-16(23)21(20)19-14/h2-8H,1H3,(H,18,23)
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18n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha2-beta2-gamma2 expressed in HEK293 cells


J Med Chem 48: 2936-43 (2005)


Article DOI: 10.1021/jm0408722
BindingDB Entry DOI: 10.7270/Q2H994QV
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Rattus norvegicus (Rat))
BDBM50000766
PNG
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1
Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
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20n/an/an/an/an/an/an/an/a



University of Firenze

Curated by ChEMBL


Assay Description
Binding affinity for recombinant rat GABA-A receptor alpha2-beta2-gamma2 subunits expressed in HEK293 cells


J Med Chem 46: 310-3 (2003)


Article DOI: 10.1021/jm020999w
BindingDB Entry DOI: 10.7270/Q2H70F59
More data for this
Ligand-Target Pair
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