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Compile Data Set for Download or QSAR

Found 1891 hits Enz. Inhib. hit(s) with Target = 'Glucagon receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucagon receptor


(Homo sapiens (Human))
BDBM50324724
PNG
((2S,5S,8S,11S,14S,20S,23S,25S)-2-((S)-1-((S)-1-((2...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C155H224N42O50S/c1-73(2)54-98(135(227)179-97(49-53-248-11)134(226)187-105(62-116(159)209)145(237)197-125(79(10)203)153(246)247)182-139(231)104(60-84-66-168-89-29-19-18-28-88(84)89)186-133(225)95(43-47-115(158)208)180-149(241)122(75(5)6)195-143(235)102(56-80-24-14-12-15-25-80)185-141(233)107(64-120(214)215)188-132(224)94(42-46-114(157)207)173-126(218)76(7)171-128(220)91(31-22-51-166-154(160)161)174-129(221)92(32-23-52-167-155(162)163)175-131(223)96-44-48-117(210)165-50-21-20-30-90(130(222)183-100(58-82-33-37-86(204)38-34-82)137(229)181-99(55-74(3)4)136(228)189-106(63-119(212)213)140(232)178-96)176-147(239)111(70-199)192-138(230)101(59-83-35-39-87(205)40-36-83)184-142(234)108(65-121(216)217)190-148(240)112(71-200)193-151(243)124(78(9)202)196-144(236)103(57-81-26-16-13-17-27-81)191-150(242)123(77(8)201)194-118(211)68-169-127(219)93(41-45-113(156)206)177-146(238)110(69-198)172-109(152(244)245)61-85-67-164-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,168,172,198-205H,20-23,30-32,41-65,68-71H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,170)(H,165,210)(H,169,219)(H,171,220)(H,173,218)(H,174,221)(H,175,223)(H,176,239)(H,177,238)(H,178,232)(H,179,227)(H,180,241)(H,181,229)(H,182,231)(H,183,222)(H,184,234)(H,185,233)(H,186,225)(H,187,226)(H,188,224)(H,189,228)(H,190,240)(H,191,242)(H,192,230)(H,193,243)(H,194,211)(H,195,235)(H,196,236)(H,197,237)(H,212,213)(H,214,215)(H,216,217)(H,244,245)(H,246,247)(H4,160,161,166)(H4,162,163,167)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0460n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324714
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C155H227N41O50S/c1-74(2)55-99(137(228)178-98(50-54-247-11)136(227)186-106(63-117(161)208)147(238)195-124(78(8)200)127(162)218)181-141(232)105(61-85-67-167-90-30-19-18-29-89(85)90)185-135(226)96(44-48-116(160)207)179-151(242)123(76(5)6)194-145(236)103(57-81-25-14-12-15-26-81)184-143(234)108(65-121(214)215)187-131(222)91(31-20-22-51-156)172-128(219)77(7)170-130(221)93(33-24-53-166-155(163)164)173-133(224)95(43-47-115(159)206)176-134(225)97(45-49-119(210)211)177-142(233)107(64-120(212)213)188-138(229)100(56-75(3)4)180-139(230)101(59-83-34-38-87(203)39-35-83)182-132(223)92(32-21-23-52-157)174-149(240)112(71-198)191-140(231)102(60-84-36-40-88(204)41-37-84)183-144(235)109(66-122(216)217)189-150(241)113(72-199)192-153(244)126(80(10)202)196-146(237)104(58-82-27-16-13-17-28-82)190-152(243)125(79(9)201)193-118(209)69-168-129(220)94(42-46-114(158)205)175-148(239)111(70-197)171-110(154(245)246)62-86-68-165-73-169-86/h12-19,25-30,34-41,67-68,73-80,91-113,123-126,167,171,197-204H,20-24,31-33,42-66,69-72,156-157H2,1-11H3,(H2,158,205)(H2,159,206)(H2,160,207)(H2,161,208)(H2,162,218)(H,165,169)(H,168,220)(H,170,221)(H,172,219)(H,173,224)(H,174,240)(H,175,239)(H,176,225)(H,177,233)(H,178,228)(H,179,242)(H,180,230)(H,181,232)(H,182,223)(H,183,235)(H,184,234)(H,185,226)(H,186,227)(H,187,222)(H,188,229)(H,189,241)(H,190,243)(H,191,231)(H,192,244)(H,193,209)(H,194,236)(H,195,238)(H,196,237)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H,245,246)(H4,163,164,166)/t77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,123-,124-,125-,126-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0480n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324702
PNG
((2S,4S,7S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C155H227N43O50S/c1-73(2)54-98(136(230)180-97(49-53-249-11)135(229)188-105(62-116(160)210)146(240)197-123(77(8)202)126(161)220)183-140(234)104(60-84-66-169-89-29-19-18-28-88(84)89)187-134(228)95(43-47-115(159)209)181-150(244)122(75(5)6)196-144(238)102(56-80-24-14-12-15-25-80)186-142(236)107(64-120(216)217)189-133(227)94(42-46-114(158)208)174-127(221)76(7)172-129(223)91(31-22-51-167-154(162)163)175-130(224)92(32-23-52-168-155(164)165)176-132(226)96(44-48-118(212)213)179-141(235)106(63-119(214)215)190-137(231)99(55-74(3)4)182-138(232)100(58-82-33-37-86(205)38-34-82)184-131(225)90(30-20-21-50-156)177-148(242)111(70-200)193-139(233)101(59-83-35-39-87(206)40-36-83)185-143(237)108(65-121(218)219)191-149(243)112(71-201)194-152(246)125(79(10)204)198-145(239)103(57-81-26-16-13-17-27-81)192-151(245)124(78(9)203)195-117(211)68-170-128(222)93(41-45-113(157)207)178-147(241)110(69-199)173-109(153(247)248)61-85-67-166-72-171-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,169,173,199-206H,20-23,30-32,41-65,68-71,156H2,1-11H3,(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,210)(H2,161,220)(H,166,171)(H,170,222)(H,172,223)(H,174,221)(H,175,224)(H,176,226)(H,177,242)(H,178,241)(H,179,235)(H,180,230)(H,181,244)(H,182,232)(H,183,234)(H,184,225)(H,185,237)(H,186,236)(H,187,228)(H,188,229)(H,189,227)(H,190,231)(H,191,243)(H,192,245)(H,193,233)(H,194,246)(H,195,211)(H,196,238)(H,197,240)(H,198,239)(H,212,213)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,162,163,167)(H4,164,165,168)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0490n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324703
PNG
((2S,4S,7S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C155H226N42O51S/c1-73(2)54-98(135(228)179-97(49-53-249-11)134(227)187-105(62-116(160)209)145(238)197-125(79(10)203)153(247)248)182-139(232)104(60-84-66-168-89-29-19-18-28-88(84)89)186-133(226)95(43-47-115(159)208)180-149(242)122(75(5)6)195-143(236)102(56-80-24-14-12-15-25-80)185-141(234)107(64-120(215)216)188-132(225)94(42-46-114(158)207)173-126(219)76(7)171-128(221)91(31-22-51-166-154(161)162)174-129(222)92(32-23-52-167-155(163)164)175-131(224)96(44-48-118(211)212)178-140(233)106(63-119(213)214)189-136(229)99(55-74(3)4)181-137(230)100(58-82-33-37-86(204)38-34-82)183-130(223)90(30-20-21-50-156)176-147(240)111(70-199)192-138(231)101(59-83-35-39-87(205)40-36-83)184-142(235)108(65-121(217)218)190-148(241)112(71-200)193-151(244)124(78(9)202)196-144(237)103(57-81-26-16-13-17-27-81)191-150(243)123(77(8)201)194-117(210)68-169-127(220)93(41-45-113(157)206)177-146(239)110(69-198)172-109(152(245)246)61-85-67-165-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,168,172,198-205H,20-23,30-32,41-65,68-71,156H2,1-11H3,(H2,157,206)(H2,158,207)(H2,159,208)(H2,160,209)(H,165,170)(H,169,220)(H,171,221)(H,173,219)(H,174,222)(H,175,224)(H,176,240)(H,177,239)(H,178,233)(H,179,228)(H,180,242)(H,181,230)(H,182,232)(H,183,223)(H,184,235)(H,185,234)(H,186,226)(H,187,227)(H,188,225)(H,189,229)(H,190,241)(H,191,243)(H,192,231)(H,193,244)(H,194,210)(H,195,236)(H,196,237)(H,197,238)(H,211,212)(H,213,214)(H,215,216)(H,217,218)(H,245,246)(H,247,248)(H4,161,162,166)(H4,163,164,167)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0530n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324706
PNG
((2S,4S,7S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)C[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C156H229N43O50S/c1-74(2)54-99(138(232)181-98(49-53-250-11)136(230)189-106(63-117(161)211)147(241)198-125(78(8)203)128(162)222)184-142(236)105(60-85-67-170-91-29-19-18-28-90(85)91)188-135(229)97(44-47-116(160)210)182-151(245)124(76(5)6)197-145(239)103(56-81-24-14-12-15-25-81)187-143(237)108(65-122(218)219)190-134(228)96(43-46-115(159)209)177-129(223)77(7)173-131(225)94(32-23-52-169-156(165)166)178-132(226)92(31-22-51-168-155(163)164)176-118(212)62-86(37-48-120(214)215)174-137(231)107(64-121(216)217)191-139(233)100(55-75(3)4)183-140(234)101(58-83-33-38-88(206)39-34-83)185-133(227)93(30-20-21-50-157)179-149(243)112(71-201)194-141(235)102(59-84-35-40-89(207)41-36-84)186-144(238)109(66-123(220)221)192-150(244)113(72-202)195-153(247)127(80(10)205)199-146(240)104(57-82-26-16-13-17-27-82)193-152(246)126(79(9)204)196-119(213)69-171-130(224)95(42-45-114(158)208)180-148(242)111(70-200)175-110(154(248)249)61-87-68-167-73-172-87/h12-19,24-29,33-36,38-41,67-68,73-80,86,92-113,124-127,170,175,200-207H,20-23,30-32,37,42-66,69-72,157H2,1-11H3,(H2,158,208)(H2,159,209)(H2,160,210)(H2,161,211)(H2,162,222)(H,167,172)(H,171,224)(H,173,225)(H,174,231)(H,176,212)(H,177,223)(H,178,226)(H,179,243)(H,180,242)(H,181,232)(H,182,245)(H,183,234)(H,184,236)(H,185,227)(H,186,238)(H,187,237)(H,188,229)(H,189,230)(H,190,228)(H,191,233)(H,192,244)(H,193,246)(H,194,235)(H,195,247)(H,196,213)(H,197,239)(H,198,241)(H,199,240)(H,214,215)(H,216,217)(H,218,219)(H,220,221)(H,248,249)(H4,163,164,168)(H4,165,166,169)/t77-,78+,79+,80+,86-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,124-,125-,126-,127-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0540n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324729
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,38S,44S)...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)CN[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H220N36O48S/c1-15-76(6)122(149(231)166-80(10)129(211)174-107(62-88-68-161-93-33-23-22-32-92(88)93)141(223)176-101(56-74(2)3)137(219)173-100(52-55-238-14)136(218)180-108(64-116(157)199)146(228)189-125(83(13)194)153(236)237)187-144(226)105(58-84-28-18-16-19-29-84)178-135(217)99(47-51-119(202)203)171-132(214)94-35-25-27-54-159-117(200)50-46-98(134(216)170-97(45-49-115(156)198)131(213)165-78(8)127(209)164-79(9)128(210)168-94)172-142(224)109(65-120(204)205)181-138(220)102(57-75(4)5)175-139(221)103(60-86-36-40-90(195)41-37-86)177-133(215)95(34-24-26-53-154)169-147(229)112(71-190)184-140(222)104(61-87-38-42-91(196)43-39-87)179-143(225)110(66-121(206)207)182-148(230)113(72-191)185-151(233)124(82(12)193)188-145(227)106(59-85-30-20-17-21-31-85)183-150(232)123(81(11)192)186-118(201)70-162-130(212)96(44-48-114(155)197)167-126(208)77(7)67-160-111(152(234)235)63-89-69-158-73-163-89/h16-23,28-33,36-43,68-69,73-83,94-113,122-125,160-161,190-196H,15,24-27,34-35,44-67,70-72,154H2,1-14H3,(H2,155,197)(H2,156,198)(H2,157,199)(H,158,163)(H,159,200)(H,162,212)(H,164,209)(H,165,213)(H,166,231)(H,167,208)(H,168,210)(H,169,229)(H,170,216)(H,171,214)(H,172,224)(H,173,219)(H,174,211)(H,175,221)(H,176,223)(H,177,215)(H,178,217)(H,179,225)(H,180,218)(H,181,220)(H,182,230)(H,183,232)(H,184,222)(H,185,233)(H,186,201)(H,187,226)(H,188,227)(H,189,228)(H,202,203)(H,204,205)(H,206,207)(H,234,235)(H,236,237)/t76-,77?,78-,79-,80-,81+,82+,83+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0550n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324725
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,38S,41S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C156H228N42O49S/c1-75(2)56-100(136(227)180-99(50-55-248-11)135(226)188-107(64-117(160)209)146(237)198-126(81(10)204)154(246)247)183-140(231)106(62-86-68-169-91-31-19-18-30-90(86)91)187-134(225)97(45-48-116(159)208)181-150(241)123(77(5)6)196-144(235)104(58-82-26-14-12-15-27-82)186-142(233)109(66-121(214)215)189-131(222)92-33-21-23-52-166-118(210)49-46-98(133(224)176-95(35-25-54-168-156(163)164)130(221)175-94(34-24-53-167-155(161)162)129(220)172-78(7)127(218)174-92)179-141(232)108(65-120(212)213)190-137(228)101(57-76(3)4)182-138(229)102(60-84-36-40-88(205)41-37-84)184-132(223)93(32-20-22-51-157)177-148(239)113(72-200)193-139(230)103(61-85-38-42-89(206)43-39-85)185-143(234)110(67-122(216)217)191-149(240)114(73-201)194-152(243)125(80(9)203)197-145(236)105(59-83-28-16-13-17-29-83)192-151(242)124(79(8)202)195-119(211)70-170-128(219)96(44-47-115(158)207)178-147(238)112(71-199)173-111(153(244)245)63-87-69-165-74-171-87/h12-19,26-31,36-43,68-69,74-81,92-114,123-126,169,173,199-206H,20-25,32-35,44-67,70-73,157H2,1-11H3,(H2,158,207)(H2,159,208)(H2,160,209)(H,165,171)(H,166,210)(H,170,219)(H,172,220)(H,174,218)(H,175,221)(H,176,224)(H,177,239)(H,178,238)(H,179,232)(H,180,227)(H,181,241)(H,182,229)(H,183,231)(H,184,223)(H,185,234)(H,186,233)(H,187,225)(H,188,226)(H,189,222)(H,190,228)(H,191,240)(H,192,242)(H,193,230)(H,194,243)(H,195,211)(H,196,235)(H,197,236)(H,198,237)(H,212,213)(H,214,215)(H,216,217)(H,244,245)(H,246,247)(H4,161,162,167)(H4,163,164,168)/t78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-,126-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0580n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324716
PNG
((2S,4S,7S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C157H233N43O49S/c1-76(2)58-102(139(232)183-101(52-57-250-11)138(231)191-109(66-118(162)211)148(241)199-125(80(8)204)128(163)221)186-143(236)108(64-87-69-171-92-31-19-18-30-91(87)92)190-136(229)98(45-49-117(161)210)184-152(245)124(78(5)6)198-146(239)106(60-83-26-14-12-15-27-83)188-137(230)100(47-51-121(215)216)181-132(225)93(32-20-22-53-158)176-129(222)79(7)174-131(224)95(34-24-55-169-156(164)165)177-133(226)96(35-25-56-170-157(166)167)178-135(228)99(46-50-120(213)214)182-144(237)110(67-122(217)218)192-140(233)103(59-77(3)4)185-141(234)104(62-85-36-40-89(207)41-37-85)187-134(227)94(33-21-23-54-159)179-150(243)114(73-202)195-142(235)105(63-86-38-42-90(208)43-39-86)189-145(238)111(68-123(219)220)193-151(244)115(74-203)196-154(247)127(82(10)206)200-147(240)107(61-84-28-16-13-17-29-84)194-153(246)126(81(9)205)197-119(212)71-172-130(223)97(44-48-116(160)209)180-149(242)113(72-201)175-112(155(248)249)65-88-70-168-75-173-88/h12-19,26-31,36-43,69-70,75-82,93-115,124-127,171,175,201-208H,20-25,32-35,44-68,71-74,158-159H2,1-11H3,(H2,160,209)(H2,161,210)(H2,162,211)(H2,163,221)(H,168,173)(H,172,223)(H,174,224)(H,176,222)(H,177,226)(H,178,228)(H,179,243)(H,180,242)(H,181,225)(H,182,237)(H,183,232)(H,184,245)(H,185,234)(H,186,236)(H,187,227)(H,188,230)(H,189,238)(H,190,229)(H,191,231)(H,192,233)(H,193,244)(H,194,246)(H,195,235)(H,196,247)(H,197,212)(H,198,239)(H,199,241)(H,200,240)(H,213,214)(H,215,216)(H,217,218)(H,219,220)(H,248,249)(H4,164,165,169)(H4,166,167,170)/t79-,80+,81+,82+,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,124-,125-,126-,127-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0680n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324708
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C154H225N43O50S/c1-72(2)52-96(134(228)178-95(47-51-248-11)133(227)186-103(60-115(159)209)145(239)196-122(76(8)201)125(160)219)181-138(232)102(58-83-65-168-88-29-19-18-28-87(83)88)185-132(226)94(43-46-114(158)208)179-149(243)121(74(5)6)195-143(237)100(54-79-24-14-12-15-25-79)184-140(234)105(62-118(213)214)187-131(225)93(42-45-113(157)207)173-126(220)75(7)171-128(222)90(31-22-49-166-153(161)162)174-129(223)91(32-23-50-167-154(163)164)175-139(233)104(61-117(211)212)189-142(236)106(63-119(215)216)188-135(229)97(53-73(3)4)180-136(230)98(56-81-33-37-85(204)38-34-81)182-130(224)89(30-20-21-48-155)176-147(241)110(69-199)192-137(231)99(57-82-35-39-86(205)40-36-82)183-141(235)107(64-120(217)218)190-148(242)111(70-200)193-151(245)124(78(10)203)197-144(238)101(55-80-26-16-13-17-27-80)191-150(244)123(77(9)202)194-116(210)67-169-127(221)92(41-44-112(156)206)177-146(240)109(68-198)172-108(152(246)247)59-84-66-165-71-170-84/h12-19,24-29,33-40,65-66,71-78,89-111,121-124,168,172,198-205H,20-23,30-32,41-64,67-70,155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,219)(H,165,170)(H,169,221)(H,171,222)(H,173,220)(H,174,223)(H,175,233)(H,176,241)(H,177,240)(H,178,228)(H,179,243)(H,180,230)(H,181,232)(H,182,224)(H,183,235)(H,184,234)(H,185,226)(H,186,227)(H,187,225)(H,188,229)(H,189,236)(H,190,242)(H,191,244)(H,192,231)(H,193,245)(H,194,210)(H,195,237)(H,196,239)(H,197,238)(H,211,212)(H,213,214)(H,215,216)(H,217,218)(H,246,247)(H4,161,162,166)(H4,163,164,167)/t75-,76+,77+,78+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0680n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324713
PNG
(CHEMBL1222087 | HSQGTFTSDYSKYLDEQAAKEFIAWLMNT)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C152H220N36O50S/c1-14-75(6)121(148(232)164-78(9)127(211)173-105(61-86-66-159-91-32-22-21-31-90(86)91)139(223)175-99(55-73(2)3)135(219)172-98(51-54-239-13)134(218)179-106(63-115(157)199)144(228)188-124(81(12)194)152(237)238)186-142(226)103(57-82-27-17-15-18-28-82)177-133(217)97(46-50-118(203)204)170-130(214)92(33-23-25-52-153)166-126(210)77(8)162-125(209)76(7)163-129(213)95(44-48-114(156)198)169-132(216)96(45-49-117(201)202)171-140(224)107(64-119(205)206)180-136(220)100(56-74(4)5)174-137(221)101(59-84-35-39-88(195)40-36-84)176-131(215)93(34-24-26-53-154)167-146(230)111(70-190)183-138(222)102(60-85-37-41-89(196)42-38-85)178-141(225)108(65-120(207)208)181-147(231)112(71-191)184-150(234)123(80(11)193)187-143(227)104(58-83-29-19-16-20-30-83)182-149(233)122(79(10)192)185-116(200)68-160-128(212)94(43-47-113(155)197)168-145(229)110(69-189)165-109(151(235)236)62-87-67-158-72-161-87/h15-22,27-32,35-42,66-67,72-81,92-112,121-124,159,165,189-196H,14,23-26,33-34,43-65,68-71,153-154H2,1-13H3,(H2,155,197)(H2,156,198)(H2,157,199)(H,158,161)(H,160,212)(H,162,209)(H,163,213)(H,164,232)(H,166,210)(H,167,230)(H,168,229)(H,169,216)(H,170,214)(H,171,224)(H,172,219)(H,173,211)(H,174,221)(H,175,223)(H,176,215)(H,177,217)(H,178,225)(H,179,218)(H,180,220)(H,181,231)(H,182,233)(H,183,222)(H,184,234)(H,185,200)(H,186,226)(H,187,227)(H,188,228)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)(H,237,238)/t75-,76-,77-,78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0680n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50098571
PNG
(CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...)
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0710n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324705
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C155H228N44O49S/c1-73(2)54-98(136(230)181-97(49-53-249-11)135(229)189-105(62-117(161)212)146(240)198-123(77(8)203)126(162)220)184-140(234)104(60-84-66-170-89-29-19-18-28-88(84)89)188-134(228)96(44-48-116(160)211)182-150(244)122(75(5)6)197-144(238)102(56-80-24-14-12-15-25-80)187-142(236)107(64-120(216)217)190-133(227)94(42-46-114(158)209)175-127(221)76(7)173-129(223)91(31-22-51-168-154(163)164)176-130(224)92(32-23-52-169-155(165)166)177-132(226)95(43-47-115(159)210)180-141(235)106(63-119(214)215)191-137(231)99(55-74(3)4)183-138(232)100(58-82-33-37-86(206)38-34-82)185-131(225)90(30-20-21-50-156)178-148(242)111(70-201)194-139(233)101(59-83-35-39-87(207)40-36-83)186-143(237)108(65-121(218)219)192-149(243)112(71-202)195-152(246)125(79(10)205)199-145(239)103(57-81-26-16-13-17-27-81)193-151(245)124(78(9)204)196-118(213)68-171-128(222)93(41-45-113(157)208)179-147(241)110(69-200)174-109(153(247)248)61-85-67-167-72-172-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,170,174,200-207H,20-23,30-32,41-65,68-71,156H2,1-11H3,(H2,157,208)(H2,158,209)(H2,159,210)(H2,160,211)(H2,161,212)(H2,162,220)(H,167,172)(H,171,222)(H,173,223)(H,175,221)(H,176,224)(H,177,226)(H,178,242)(H,179,241)(H,180,235)(H,181,230)(H,182,244)(H,183,232)(H,184,234)(H,185,225)(H,186,237)(H,187,236)(H,188,228)(H,189,229)(H,190,227)(H,191,231)(H,192,243)(H,193,245)(H,194,233)(H,195,246)(H,196,213)(H,197,238)(H,198,240)(H,199,239)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,163,164,168)(H4,165,166,169)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0710n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324717
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C161H240N44O51S/c1-13-79(6)126(155(251)187-100(47-50-119(165)216)139(235)193-109(64-89-70-175-94-33-21-20-32-93(89)94)145(241)189-103(58-77(2)3)141(237)186-102(52-57-257-12)140(236)194-110(66-120(166)217)151(247)205-130(84(11)212)158(254)203-127(81(8)209)131(167)227)202-149(245)107(60-85-28-16-14-17-29-85)192-147(243)112(68-124(223)224)195-136(232)95(34-22-24-53-162)180-132(228)80(7)178-134(230)97(36-26-55-173-160(168)169)181-135(231)98(37-27-56-174-161(170)171)182-138(234)101(48-51-122(219)220)185-146(242)111(67-123(221)222)196-142(238)104(59-78(4)5)188-143(239)105(62-87-38-42-91(213)43-39-87)190-137(233)96(35-23-25-54-163)183-153(249)116(74-207)199-144(240)106(63-88-40-44-92(214)45-41-88)191-148(244)113(69-125(225)226)197-154(250)117(75-208)200-157(253)129(83(10)211)204-150(246)108(61-86-30-18-15-19-31-86)198-156(252)128(82(9)210)201-121(218)72-176-133(229)99(46-49-118(164)215)184-152(248)115(73-206)179-114(159(255)256)65-90-71-172-76-177-90/h14-21,28-33,38-45,70-71,76-84,95-117,126-130,175,179,206-214H,13,22-27,34-37,46-69,72-75,162-163H2,1-12H3,(H2,164,215)(H2,165,216)(H2,166,217)(H2,167,227)(H,172,177)(H,176,229)(H,178,230)(H,180,228)(H,181,231)(H,182,234)(H,183,249)(H,184,248)(H,185,242)(H,186,237)(H,187,251)(H,188,239)(H,189,241)(H,190,233)(H,191,244)(H,192,243)(H,193,235)(H,194,236)(H,195,232)(H,196,238)(H,197,250)(H,198,252)(H,199,240)(H,200,253)(H,201,218)(H,202,245)(H,203,254)(H,204,246)(H,205,247)(H,219,220)(H,221,222)(H,223,224)(H,225,226)(H,255,256)(H4,168,169,173)(H4,170,171,174)/t79-,80-,81+,82+,83+,84+,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,126-,127-,128-,129-,130-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0730n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324727
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C
Show InChI InChI=1S/C155H227N41O49S/c1-75(2)56-100-135(225)178-99(50-55-246-11)133(223)173-93(134(224)196-125(81(10)203)153(244)245)33-21-23-52-164-117(208)49-46-98(132(222)185-106(139(229)181-100)62-86-67-167-91-31-19-18-30-90(86)91)179-149(239)122(77(5)6)194-143(233)104(58-82-26-14-12-15-27-82)184-140(230)107(64-119(210)211)186-131(221)97(45-48-116(158)207)172-126(216)78(7)170-128(218)94(34-24-53-165-154(159)160)174-129(219)95(35-25-54-166-155(161)162)176-147(237)113(72-199)191-142(232)109(66-121(214)215)187-136(226)101(57-76(3)4)180-137(227)102(60-84-36-40-88(204)41-37-84)182-130(220)92(32-20-22-51-156)175-146(236)112(71-198)190-138(228)103(61-85-38-42-89(205)43-39-85)183-141(231)108(65-120(212)213)188-148(238)114(73-200)192-151(241)124(80(9)202)195-144(234)105(59-83-28-16-13-17-29-83)189-150(240)123(79(8)201)193-118(209)69-168-127(217)96(44-47-115(157)206)177-145(235)111(70-197)171-110(152(242)243)63-87-68-163-74-169-87/h12-19,26-31,36-43,67-68,74-81,92-114,122-125,167,171,197-205H,20-25,32-35,44-66,69-73,156H2,1-11H3,(H2,157,206)(H2,158,207)(H,163,169)(H,164,208)(H,168,217)(H,170,218)(H,172,216)(H,173,223)(H,174,219)(H,175,236)(H,176,237)(H,177,235)(H,178,225)(H,179,239)(H,180,227)(H,181,229)(H,182,220)(H,183,231)(H,184,230)(H,185,222)(H,186,221)(H,187,226)(H,188,238)(H,189,240)(H,190,228)(H,191,232)(H,192,241)(H,193,209)(H,194,233)(H,195,234)(H,196,224)(H,210,211)(H,212,213)(H,214,215)(H,242,243)(H,244,245)(H4,159,160,165)(H4,161,162,166)/t78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,122-,123-,124-,125-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0760n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324711
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C156H231N43O49S/c1-75(2)56-100(137(230)181-99(50-55-249-11)136(229)189-107(64-117(161)210)147(240)198-124(79(8)203)127(162)220)184-141(234)106(62-86-68-170-91-31-19-18-30-90(86)91)188-135(228)97(45-48-116(160)209)182-151(244)123(77(5)6)197-145(238)104(58-82-26-14-12-15-27-82)187-143(236)109(66-121(216)217)190-132(225)92(32-20-22-51-157)175-128(221)78(7)173-130(223)94(34-24-53-168-155(163)164)176-131(224)95(35-25-54-169-156(165)166)177-134(227)98(46-49-119(212)213)180-142(235)108(65-120(214)215)191-138(231)101(57-76(3)4)183-139(232)102(60-84-36-40-88(206)41-37-84)185-133(226)93(33-21-23-52-158)178-149(242)113(72-201)194-140(233)103(61-85-38-42-89(207)43-39-85)186-144(237)110(67-122(218)219)192-150(243)114(73-202)195-153(246)126(81(10)205)199-146(239)105(59-83-28-16-13-17-29-83)193-152(245)125(80(9)204)196-118(211)70-171-129(222)96(44-47-115(159)208)179-148(241)112(71-200)174-111(154(247)248)63-87-69-167-74-172-87/h12-19,26-31,36-43,68-69,74-81,92-114,123-126,170,174,200-207H,20-25,32-35,44-67,70-73,157-158H2,1-11H3,(H2,159,208)(H2,160,209)(H2,161,210)(H2,162,220)(H,167,172)(H,171,222)(H,173,223)(H,175,221)(H,176,224)(H,177,227)(H,178,242)(H,179,241)(H,180,235)(H,181,230)(H,182,244)(H,183,232)(H,184,234)(H,185,226)(H,186,237)(H,187,236)(H,188,228)(H,189,229)(H,190,225)(H,191,231)(H,192,243)(H,193,245)(H,194,233)(H,195,246)(H,196,211)(H,197,238)(H,198,240)(H,199,239)(H,212,213)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,163,164,168)(H4,165,166,169)/t78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-,126-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0770n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324726
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,38S,41S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C154H225N41O49S/c1-74(2)54-98(133(223)176-97(48-53-245-11)132(222)184-105(62-115(157)206)143(233)195-124(80(10)202)152(243)244)179-137(227)104(60-85-66-166-90-31-19-18-30-89(85)90)183-131(221)96-45-47-116(207)163-50-23-21-33-91(129(219)185-106(63-118(209)210)138(228)182-102(56-81-26-14-12-15-27-81)141(231)193-121(76(5)6)148(238)177-96)171-125(215)77(7)169-127(217)93(34-24-51-164-153(158)159)172-128(218)94(35-25-52-165-154(160)161)174-146(236)112(71-198)190-140(230)108(65-120(213)214)186-134(224)99(55-75(3)4)178-135(225)100(58-83-36-40-87(203)41-37-83)180-130(220)92(32-20-22-49-155)173-145(235)111(70-197)189-136(226)101(59-84-38-42-88(204)43-39-84)181-139(229)107(64-119(211)212)187-147(237)113(72-199)191-150(240)123(79(9)201)194-142(232)103(57-82-28-16-13-17-29-82)188-149(239)122(78(8)200)192-117(208)68-167-126(216)95(44-46-114(156)205)175-144(234)110(69-196)170-109(151(241)242)61-86-67-162-73-168-86/h12-19,26-31,36-43,66-67,73-80,91-113,121-124,166,170,196-204H,20-25,32-35,44-65,68-72,155H2,1-11H3,(H2,156,205)(H2,157,206)(H,162,168)(H,163,207)(H,167,216)(H,169,217)(H,171,215)(H,172,218)(H,173,235)(H,174,236)(H,175,234)(H,176,223)(H,177,238)(H,178,225)(H,179,227)(H,180,220)(H,181,229)(H,182,228)(H,183,221)(H,184,222)(H,185,219)(H,186,224)(H,187,237)(H,188,239)(H,189,226)(H,190,230)(H,191,240)(H,192,208)(H,193,231)(H,194,232)(H,195,233)(H,209,210)(H,211,212)(H,213,214)(H,241,242)(H,243,244)(H4,158,159,164)(H4,160,161,165)/t77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,121-,122-,123-,124-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0780n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324718
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C154H228N42O48S/c1-74(2)55-99(135(226)179-98(49-54-245-12)134(225)186-106(63-115(158)206)145(236)195-122(79(9)200)125(159)216)182-139(230)105(61-86-67-167-91-32-20-19-31-90(86)91)180-127(218)78(8)171-149(240)121(76(5)6)194-143(234)103(57-82-27-15-13-16-28-82)185-141(232)108(65-119(212)213)187-131(222)92(33-21-23-50-155)173-126(217)77(7)170-129(220)94(35-25-52-165-153(160)161)174-130(221)95(36-26-53-166-154(162)163)175-133(224)97(46-48-117(208)209)178-140(231)107(64-118(210)211)188-136(227)100(56-75(3)4)181-137(228)101(59-84-37-41-88(203)42-38-84)183-132(223)93(34-22-24-51-156)176-147(238)112(71-198)191-138(229)102(60-85-39-43-89(204)44-40-85)184-142(233)109(66-120(214)215)189-148(239)113(72-199)192-151(242)124(81(11)202)196-144(235)104(58-83-29-17-14-18-30-83)190-150(241)123(80(10)201)193-116(207)69-168-128(219)96(45-47-114(157)205)177-146(237)111(70-197)172-110(152(243)244)62-87-68-164-73-169-87/h13-20,27-32,37-44,67-68,73-81,92-113,121-124,167,172,197-204H,21-26,33-36,45-66,69-72,155-156H2,1-12H3,(H2,157,205)(H2,158,206)(H2,159,216)(H,164,169)(H,168,219)(H,170,220)(H,171,240)(H,173,217)(H,174,221)(H,175,224)(H,176,238)(H,177,237)(H,178,231)(H,179,226)(H,180,218)(H,181,228)(H,182,230)(H,183,223)(H,184,233)(H,185,232)(H,186,225)(H,187,222)(H,188,227)(H,189,239)(H,190,241)(H,191,229)(H,192,242)(H,193,207)(H,194,234)(H,195,236)(H,196,235)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H,243,244)(H4,160,161,165)(H4,162,163,166)/t77-,78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,121-,122-,123-,124-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0800n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324715
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C153H224N40O49S/c1-73(2)54-98(135(224)175-97(49-53-243-12)134(223)183-105(62-115(158)204)145(234)192-122(78(9)197)125(159)214)178-139(228)104(60-85-66-164-90-31-20-19-30-89(85)90)182-133(222)95(44-47-114(157)203)176-149(238)121(75(5)6)191-143(232)102(56-81-26-15-13-16-27-81)181-141(230)107(64-119(210)211)184-130(219)91(32-21-23-50-154)170-127(216)77(8)167-126(215)76(7)168-129(218)93(34-25-52-163-153(160)161)171-132(221)96(45-48-117(206)207)174-140(229)106(63-118(208)209)185-136(225)99(55-74(3)4)177-137(226)100(58-83-35-39-87(200)40-36-83)179-131(220)92(33-22-24-51-155)172-147(236)111(70-195)188-138(227)101(59-84-37-41-88(201)42-38-84)180-142(231)108(65-120(212)213)186-148(237)112(71-196)189-151(240)124(80(11)199)193-144(233)103(57-82-28-17-14-18-29-82)187-150(239)123(79(10)198)190-116(205)68-165-128(217)94(43-46-113(156)202)173-146(235)110(69-194)169-109(152(241)242)61-86-67-162-72-166-86/h13-20,26-31,35-42,66-67,72-80,91-112,121-124,164,169,194-201H,21-25,32-34,43-65,68-71,154-155H2,1-12H3,(H2,156,202)(H2,157,203)(H2,158,204)(H2,159,214)(H,162,166)(H,165,217)(H,167,215)(H,168,218)(H,170,216)(H,171,221)(H,172,236)(H,173,235)(H,174,229)(H,175,224)(H,176,238)(H,177,226)(H,178,228)(H,179,220)(H,180,231)(H,181,230)(H,182,222)(H,183,223)(H,184,219)(H,185,225)(H,186,237)(H,187,239)(H,188,227)(H,189,240)(H,190,205)(H,191,232)(H,192,234)(H,193,233)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H,241,242)(H4,160,161,163)/t76-,77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0870n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324707
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCS(O)(=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C154H227N43O51S2/c1-73(2)54-98(135(227)178-96(47-52-249-11)133(225)187-105(62-116(159)209)145(237)196-122(77(8)201)125(160)217)182-139(231)104(60-84-66-168-89-29-19-18-28-88(84)89)186-132(224)95(43-46-115(158)208)180-149(241)121(75(5)6)195-143(235)102(56-80-24-14-12-15-25-80)185-141(233)107(64-119(213)214)188-131(223)94(42-45-114(157)207)173-126(218)76(7)171-128(220)91(31-22-50-166-153(161)162)174-129(221)92(32-23-51-167-154(163)164)175-134(226)97(48-53-250(246,247)248)179-140(232)106(63-118(211)212)189-136(228)99(55-74(3)4)181-137(229)100(58-82-33-37-86(204)38-34-82)183-130(222)90(30-20-21-49-155)176-147(239)111(70-199)192-138(230)101(59-83-35-39-87(205)40-36-83)184-142(234)108(65-120(215)216)190-148(240)112(71-200)193-151(243)124(79(10)203)197-144(236)103(57-81-26-16-13-17-27-81)191-150(242)123(78(9)202)194-117(210)68-169-127(219)93(41-44-113(156)206)177-146(238)110(69-198)172-109(152(244)245)61-85-67-165-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,121-124,168,172,198-205H,20-23,30-32,41-65,68-71,155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,217)(H,165,170)(H,169,219)(H,171,220)(H,173,218)(H,174,221)(H,175,226)(H,176,239)(H,177,238)(H,178,227)(H,179,232)(H,180,241)(H,181,229)(H,182,231)(H,183,222)(H,184,234)(H,185,233)(H,186,224)(H,187,225)(H,188,223)(H,189,228)(H,190,240)(H,191,242)(H,192,230)(H,193,243)(H,194,210)(H,195,235)(H,196,237)(H,197,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,161,162,166)(H4,163,164,167)(H,246,247,248)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.100n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324704
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C156H227N45O48S/c1-74(2)52-99(136(230)182-98(47-51-250-11)135(229)191-107(61-118(161)213)147(241)200-124(78(8)205)127(162)221)185-140(234)105(58-85-65-171-91-29-19-18-28-90(85)91)189-134(228)97(43-46-117(160)212)183-151(245)123(76(5)6)199-145(239)103(54-81-24-14-12-15-25-81)188-142(236)108(62-120(215)216)192-133(227)96(42-45-116(159)211)177-128(222)77(7)175-130(224)93(31-22-49-169-155(163)164)178-131(225)94(32-23-50-170-156(165)166)179-141(235)106(59-86-66-167-72-173-86)190-144(238)109(63-121(217)218)193-137(231)100(53-75(3)4)184-138(232)101(56-83-33-37-88(208)38-34-83)186-132(226)92(30-20-21-48-157)180-149(243)113(70-203)196-139(233)102(57-84-35-39-89(209)40-36-84)187-143(237)110(64-122(219)220)194-150(244)114(71-204)197-153(247)126(80(10)207)201-146(240)104(55-82-26-16-13-17-27-82)195-152(246)125(79(9)206)198-119(214)68-172-129(223)95(41-44-115(158)210)181-148(242)112(69-202)176-111(154(248)249)60-87-67-168-73-174-87/h12-19,24-29,33-40,65-67,72-80,92-114,123-126,171,176,202-209H,20-23,30-32,41-64,68-71,157H2,1-11H3,(H2,158,210)(H2,159,211)(H2,160,212)(H2,161,213)(H2,162,221)(H,167,173)(H,168,174)(H,172,223)(H,175,224)(H,177,222)(H,178,225)(H,179,235)(H,180,243)(H,181,242)(H,182,230)(H,183,245)(H,184,232)(H,185,234)(H,186,226)(H,187,237)(H,188,236)(H,189,228)(H,190,238)(H,191,229)(H,192,227)(H,193,231)(H,194,244)(H,195,246)(H,196,233)(H,197,247)(H,198,214)(H,199,239)(H,200,241)(H,201,240)(H,215,216)(H,217,218)(H,219,220)(H,248,249)(H4,163,164,169)(H4,165,166,170)/t77-,78+,79+,80+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-,126-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.100n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324723
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C154H229N43O48S/c1-74(2)54-98(134(226)178-97(48-53-246-11)133(225)186-105(62-116(159)209)144(236)196-122(78(8)202)125(160)217)181-138(230)104(60-85-66-168-90-31-19-18-30-89(85)90)185-132(224)96(45-47-115(158)208)179-149(241)121(76(5)6)195-142(234)102(56-81-26-14-12-15-27-81)184-139(231)106(63-118(211)212)187-130(222)91(32-20-22-49-155)173-126(218)77(7)171-128(220)93(34-24-51-166-153(161)162)174-129(221)94(35-25-52-167-154(163)164)176-147(239)112(71-200)192-141(233)108(65-120(215)216)188-135(227)99(55-75(3)4)180-136(228)100(58-83-36-40-87(205)41-37-83)182-131(223)92(33-21-23-50-156)175-146(238)111(70-199)191-137(229)101(59-84-38-42-88(206)43-39-84)183-140(232)107(64-119(213)214)189-148(240)113(72-201)193-151(243)124(80(10)204)197-143(235)103(57-82-28-16-13-17-29-82)190-150(242)123(79(9)203)194-117(210)68-169-127(219)95(44-46-114(157)207)177-145(237)110(69-198)172-109(152(244)245)61-86-67-165-73-170-86/h12-19,26-31,36-43,66-67,73-80,91-113,121-124,168,172,198-206H,20-25,32-35,44-65,68-72,155-156H2,1-11H3,(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,217)(H,165,170)(H,169,219)(H,171,220)(H,173,218)(H,174,221)(H,175,238)(H,176,239)(H,177,237)(H,178,226)(H,179,241)(H,180,228)(H,181,230)(H,182,223)(H,183,232)(H,184,231)(H,185,224)(H,186,225)(H,187,222)(H,188,227)(H,189,240)(H,190,242)(H,191,229)(H,192,233)(H,193,243)(H,194,210)(H,195,234)(H,196,236)(H,197,235)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,161,162,166)(H4,163,164,167)/t77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,121-,122-,123-,124-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.120n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324709
PNG
((2S,5S,8S,11S,14S,20S,23S,26S,29S,32S,35S,38S,41S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C152H223N43O48S/c1-72(2)52-96(134(226)177-95(47-51-244-11)133(225)185-103(60-114(157)207)143(235)194-121(76(8)199)124(158)216)180-138(230)102(58-83-64-166-88-29-19-18-28-87(83)88)184-132(224)94(43-46-113(156)206)178-147(239)120(74(5)6)193-141(233)100(54-79-24-14-12-15-25-79)183-139(231)105(62-118(212)213)187-131(223)93(42-45-112(155)205)173-125(217)75(7)170-128(220)91(32-23-50-165-152(161)162)174-129(221)89(31-22-49-164-151(159)160)172-115(208)66-168-127(219)104(61-117(210)211)186-135(227)97(53-73(3)4)179-136(228)98(56-81-33-37-85(202)38-34-81)181-130(222)90(30-20-21-48-153)175-145(237)109(69-197)190-137(229)99(57-82-35-39-86(203)40-36-82)182-140(232)106(63-119(214)215)188-146(238)110(70-198)191-149(241)123(78(10)201)195-142(234)101(55-80-26-16-13-17-27-80)189-148(240)122(77(9)200)192-116(209)67-167-126(218)92(41-44-111(154)204)176-144(236)108(68-196)171-107(150(242)243)59-84-65-163-71-169-84/h12-19,24-29,33-40,64-65,71-78,89-110,120-123,166,171,196-203H,20-23,30-32,41-63,66-70,153H2,1-11H3,(H2,154,204)(H2,155,205)(H2,156,206)(H2,157,207)(H2,158,216)(H,163,169)(H,167,218)(H,168,219)(H,170,220)(H,172,208)(H,173,217)(H,174,221)(H,175,237)(H,176,236)(H,177,226)(H,178,239)(H,179,228)(H,180,230)(H,181,222)(H,182,232)(H,183,231)(H,184,224)(H,185,225)(H,186,227)(H,187,223)(H,188,238)(H,189,240)(H,190,229)(H,191,241)(H,192,209)(H,193,233)(H,194,235)(H,195,234)(H,210,211)(H,212,213)(H,214,215)(H,242,243)(H4,159,160,164)(H4,161,162,165)/t75-,76+,77+,78+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,120-,121-,122-,123-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.130n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324710
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C154H227N43O49S/c1-72(2)53-97(134(227)177-96(48-52-247-12)133(226)186-104(61-115(159)210)143(236)195-121(76(8)201)125(160)218)181-138(231)103(59-84-65-168-89-30-20-19-29-88(84)89)185-132(225)95(44-47-114(158)209)179-148(241)120(74(5)6)194-141(234)101(55-80-25-15-13-16-26-80)184-139(232)105(62-117(212)213)187-131(224)94(43-46-113(157)208)173-126(219)75(7)171-128(221)91(32-23-50-166-153(161)162)174-129(222)92(33-24-51-167-154(163)164)178-150(243)123(78(10)203)197-144(237)107(64-119(216)217)188-135(228)98(54-73(3)4)180-136(229)99(57-82-34-38-86(205)39-35-82)182-130(223)90(31-21-22-49-155)175-146(239)110(69-199)191-137(230)100(58-83-36-40-87(206)41-37-83)183-140(233)106(63-118(214)215)189-147(240)111(70-200)192-151(244)124(79(11)204)196-142(235)102(56-81-27-17-14-18-28-81)190-149(242)122(77(9)202)193-116(211)67-169-127(220)93(42-45-112(156)207)176-145(238)109(68-198)172-108(152(245)246)60-85-66-165-71-170-85/h13-20,25-30,34-41,65-66,71-79,90-111,120-124,168,172,198-206H,21-24,31-33,42-64,67-70,155H2,1-12H3,(H2,156,207)(H2,157,208)(H2,158,209)(H2,159,210)(H2,160,218)(H,165,170)(H,169,220)(H,171,221)(H,173,219)(H,174,222)(H,175,239)(H,176,238)(H,177,227)(H,178,243)(H,179,241)(H,180,229)(H,181,231)(H,182,223)(H,183,233)(H,184,232)(H,185,225)(H,186,226)(H,187,224)(H,188,228)(H,189,240)(H,190,242)(H,191,230)(H,192,244)(H,193,211)(H,194,234)(H,195,236)(H,196,235)(H,197,237)(H,212,213)(H,214,215)(H,216,217)(H,245,246)(H4,161,162,166)(H4,163,164,167)/t75-,76+,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-,124-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.130n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324732
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-96(133(226)177-95(47-51-246-11)132(225)185-103(60-115(158)209)143(236)195-121(76(8)201)124(159)217)180-137(230)102(58-83-64-167-88-29-19-18-28-87(83)88)184-131(224)94(43-46-114(157)208)178-148(241)120(74(5)6)194-141(234)100(54-79-24-14-12-15-25-79)183-138(231)104(61-117(211)212)186-130(223)93(42-45-113(156)207)172-125(218)75(7)170-127(220)90(31-22-49-165-152(160)161)173-128(221)91(32-23-50-166-153(162)163)175-146(239)110(69-199)191-140(233)106(63-119(215)216)187-134(227)97(53-73(3)4)179-135(228)98(56-81-33-37-85(204)38-34-81)181-129(222)89(30-20-21-48-154)174-145(238)109(68-198)190-136(229)99(57-82-35-39-86(205)40-36-82)182-139(232)105(62-118(213)214)188-147(240)111(70-200)192-150(243)123(78(10)203)196-142(235)101(55-80-26-16-13-17-27-80)189-149(242)122(77(9)202)193-116(210)66-168-126(219)92(41-44-112(155)206)176-144(237)108(67-197)171-107(151(244)245)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,89-111,120-123,167,171,197-205H,20-23,30-32,41-63,66-70,154H2,1-11H3,(H2,155,206)(H2,156,207)(H2,157,208)(H2,158,209)(H2,159,217)(H,164,169)(H,168,219)(H,170,220)(H,172,218)(H,173,221)(H,174,238)(H,175,239)(H,176,237)(H,177,226)(H,178,241)(H,179,228)(H,180,230)(H,181,222)(H,182,232)(H,183,231)(H,184,224)(H,185,225)(H,186,223)(H,187,227)(H,188,240)(H,189,242)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,236)(H,196,235)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.150n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324712
PNG
(CHEMBL1222086 | HSQGTFTSDYSKYLDEQAAKEFIAWLVKG)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(O)=O
Show InChI InChI=1S/C152H222N36O48/c1-14-78(8)123(149(232)165-81(11)128(211)174-107(63-88-67-159-93-34-22-21-33-92(88)93)139(222)176-102(58-76(4)5)142(225)186-122(77(6)7)148(231)173-94(35-23-26-54-153)129(212)161-70-121(207)208)187-143(226)105(59-84-29-17-15-18-30-84)178-135(218)100(49-53-118(201)202)171-132(215)95(36-24-27-55-154)167-127(210)80(10)163-126(209)79(9)164-131(214)98(47-51-115(157)197)170-134(217)99(48-52-117(199)200)172-140(223)108(65-119(203)204)180-136(219)101(57-75(2)3)175-137(220)103(61-86-38-42-90(194)43-39-86)177-133(216)96(37-25-28-56-155)168-146(229)112(72-190)183-138(221)104(62-87-40-44-91(195)45-41-87)179-141(224)109(66-120(205)206)181-147(230)113(73-191)184-151(234)125(83(13)193)188-144(227)106(60-85-31-19-16-20-32-85)182-150(233)124(82(12)192)185-116(198)69-160-130(213)97(46-50-114(156)196)169-145(228)111(71-189)166-110(152(235)236)64-89-68-158-74-162-89/h15-22,29-34,38-45,67-68,74-83,94-113,122-125,159,166,189-195H,14,23-28,35-37,46-66,69-73,153-155H2,1-13H3,(H2,156,196)(H2,157,197)(H,158,162)(H,160,213)(H,161,212)(H,163,209)(H,164,214)(H,165,232)(H,167,210)(H,168,229)(H,169,228)(H,170,217)(H,171,215)(H,172,223)(H,173,231)(H,174,211)(H,175,220)(H,176,222)(H,177,216)(H,178,218)(H,179,224)(H,180,219)(H,181,230)(H,182,233)(H,183,221)(H,184,234)(H,185,198)(H,186,225)(H,187,226)(H,188,227)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)/t78-,79-,80-,81-,82+,83+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.470n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324728
PNG
((2S,8S,14S,17S,20S,23S,26S,29S,32S,35S,38S,41S,44S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)CN[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H222N36O49S/c1-15-76(6)122(149(232)166-80(10)129(212)174-107(62-88-68-161-93-33-23-22-32-92(88)93)141(224)176-101(56-74(2)3)137(220)173-100(52-55-239-14)136(219)180-108(64-116(158)199)146(229)189-125(83(13)194)153(237)238)187-144(227)105(58-84-28-18-16-19-29-84)178-135(218)99(47-51-119(203)204)171-132(215)94(34-24-26-53-154)168-128(211)79(9)164-127(210)78(8)165-131(214)97(45-49-115(157)198)170-134(217)98(46-50-118(201)202)172-142(225)109(65-120(205)206)181-138(221)102(57-75(4)5)175-139(222)103(60-86-36-40-90(195)41-37-86)177-133(216)95(35-25-27-54-155)169-147(230)112(71-190)184-140(223)104(61-87-38-42-91(196)43-39-87)179-143(226)110(66-121(207)208)182-148(231)113(72-191)185-151(234)124(82(12)193)188-145(228)106(59-85-30-20-17-21-31-85)183-150(233)123(81(11)192)186-117(200)70-162-130(213)96(44-48-114(156)197)167-126(209)77(7)67-160-111(152(235)236)63-89-69-159-73-163-89/h16-23,28-33,36-43,68-69,73-83,94-113,122-125,160-161,190-196H,15,24-27,34-35,44-67,70-72,154-155H2,1-14H3,(H2,156,197)(H2,157,198)(H2,158,199)(H,159,163)(H,162,213)(H,164,210)(H,165,214)(H,166,232)(H,167,209)(H,168,211)(H,169,230)(H,170,217)(H,171,215)(H,172,225)(H,173,220)(H,174,212)(H,175,222)(H,176,224)(H,177,216)(H,178,218)(H,179,226)(H,180,219)(H,181,221)(H,182,231)(H,183,233)(H,184,223)(H,185,234)(H,186,200)(H,187,227)(H,188,228)(H,189,229)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)(H,237,238)/t76-,77?,78-,79-,80-,81+,82+,83+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.590n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324721
PNG
((2S,4S,7S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S,...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C152H219N35O51S/c1-14-75(6)121(148(232)163-78(9)127(211)172-105(61-86-66-158-91-32-22-21-31-90(86)91)139(223)174-99(55-73(2)3)135(219)171-98(51-54-239-13)134(218)178-106(63-114(156)197)144(228)187-124(81(12)193)152(237)238)185-142(226)103(57-82-27-17-15-18-28-82)176-133(217)97(46-50-118(203)204)169-130(214)92(33-23-25-52-153)165-126(210)77(8)161-125(209)76(7)162-129(213)95(43-47-113(155)196)168-132(216)96(45-49-117(201)202)170-140(224)107(64-119(205)206)179-136(220)100(56-74(4)5)173-137(221)101(59-84-35-39-88(194)40-36-84)175-131(215)93(34-24-26-53-154)166-146(230)111(70-189)182-138(222)102(60-85-37-41-89(195)42-38-85)177-141(225)108(65-120(207)208)180-147(231)112(71-190)183-150(234)123(80(11)192)186-143(227)104(58-83-29-19-16-20-30-83)181-149(233)122(79(10)191)184-115(198)68-159-128(212)94(44-48-116(199)200)167-145(229)110(69-188)164-109(151(235)236)62-87-67-157-72-160-87/h15-22,27-32,35-42,66-67,72-81,92-112,121-124,158,164,188-195H,14,23-26,33-34,43-65,68-71,153-154H2,1-13H3,(H2,155,196)(H2,156,197)(H,157,160)(H,159,212)(H,161,209)(H,162,213)(H,163,232)(H,165,210)(H,166,230)(H,167,229)(H,168,216)(H,169,214)(H,170,224)(H,171,219)(H,172,211)(H,173,221)(H,174,223)(H,175,215)(H,176,217)(H,177,225)(H,178,218)(H,179,220)(H,180,231)(H,181,233)(H,182,222)(H,183,234)(H,184,198)(H,185,226)(H,186,227)(H,187,228)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)(H,237,238)/t75-,76-,77-,78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.40n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324720
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C155H226N42O51S/c1-73(2)54-98(136(230)179-97(49-53-249-11)135(229)187-105(62-115(159)208)146(240)196-123(77(8)201)126(160)220)182-140(234)104(60-84-66-168-89-29-19-18-28-88(84)89)186-134(228)95(42-46-114(158)207)180-150(244)122(75(5)6)195-144(238)102(56-80-24-14-12-15-25-80)185-142(236)107(64-120(216)217)188-133(227)94(41-45-113(157)206)173-127(221)76(7)171-129(223)91(31-22-51-166-154(161)162)174-130(224)92(32-23-52-167-155(163)164)175-132(226)96(44-48-118(212)213)178-141(235)106(63-119(214)215)189-137(231)99(55-74(3)4)181-138(232)100(58-82-33-37-86(204)38-34-82)183-131(225)90(30-20-21-50-156)176-148(242)111(70-199)192-139(233)101(59-83-35-39-87(205)40-36-83)184-143(237)108(65-121(218)219)190-149(243)112(71-200)193-152(246)125(79(10)203)197-145(239)103(57-81-26-16-13-17-27-81)191-151(245)124(78(9)202)194-116(209)68-169-128(222)93(43-47-117(210)211)177-147(241)110(69-198)172-109(153(247)248)61-85-67-165-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,168,172,198-205H,20-23,30-32,41-65,68-71,156H2,1-11H3,(H2,157,206)(H2,158,207)(H2,159,208)(H2,160,220)(H,165,170)(H,169,222)(H,171,223)(H,173,221)(H,174,224)(H,175,226)(H,176,242)(H,177,241)(H,178,235)(H,179,230)(H,180,244)(H,181,232)(H,182,234)(H,183,225)(H,184,237)(H,185,236)(H,186,228)(H,187,229)(H,188,227)(H,189,231)(H,190,243)(H,191,245)(H,192,233)(H,193,246)(H,194,209)(H,195,238)(H,196,240)(H,197,239)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,161,162,166)(H4,163,164,167)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.70n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098571
PNG
(CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...)
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 5n/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay


J Med Chem 43: 1714-22 (2000)


Article DOI: 10.1021/jm990559d
BindingDB Entry DOI: 10.7270/Q2XG9RVJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098571
PNG
(CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...)
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 8n/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
cAMP accumulation in rat hepatocytes in the presence rolipram


J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324719
PNG
(CHEMBL1222093 | HAEGTFTSDVSSYLEERRAQDFVQWLMNT)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C149H220N40O51S/c1-68(2)51-93(173-132(223)95(55-79-33-35-82(196)36-34-79)176-139(230)103(64-190)182-141(232)105(66-192)183-143(234)116(71(7)8)187-138(229)101(60-114(209)210)180-140(231)104(65-191)184-145(236)118(75(12)194)188-136(227)97(54-78-27-19-16-20-28-78)181-144(235)117(74(11)193)185-109(200)63-161-122(213)87(39-44-110(201)202)165-120(211)72(9)163-102(146(237)238)57-81-62-157-67-162-81)130(221)170-91(41-46-112(205)206)126(217)169-90(40-45-111(203)204)125(216)168-86(32-24-49-159-149(155)156)124(215)167-85(31-23-48-158-148(153)154)123(214)164-73(10)121(212)166-88(37-42-106(150)197)127(218)179-100(59-113(207)208)134(225)175-96(53-77-25-17-15-18-26-77)135(226)186-115(70(5)6)142(233)172-89(38-43-107(151)198)128(219)177-98(56-80-61-160-84-30-22-21-29-83(80)84)133(224)174-94(52-69(3)4)131(222)171-92(47-50-241-14)129(220)178-99(58-108(152)199)137(228)189-119(76(13)195)147(239)240/h15-22,25-30,33-36,61-62,67-76,85-105,115-119,160,163,190-196H,23-24,31-32,37-60,63-66H2,1-14H3,(H2,150,197)(H2,151,198)(H2,152,199)(H,157,162)(H,161,213)(H,164,214)(H,165,211)(H,166,212)(H,167,215)(H,168,216)(H,169,217)(H,170,221)(H,171,222)(H,172,233)(H,173,223)(H,174,224)(H,175,225)(H,176,230)(H,177,219)(H,178,220)(H,179,218)(H,180,231)(H,181,235)(H,182,232)(H,183,234)(H,184,236)(H,185,200)(H,186,226)(H,187,229)(H,188,227)(H,189,228)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,209,210)(H,237,238)(H,239,240)(H4,153,154,158)(H4,155,156,159)/t72-,73-,74+,75+,76+,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,115-,116-,117-,118-,119-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 50n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50087848
PNG
(CHEMBL427644 | c[Asp15, Lys18,] glucagon-NH2)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc2cnc[nH]2)[C@H](C)O)[C@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(N)=O)C(=O)N1)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C154H226N40O47S/c1-75(2)56-101(138(225)175-100(51-55-242-11)137(224)183-108(64-118(161)207)147(234)193-124(79(8)199)127(162)214)178-142(229)107(62-86-67-165-92-31-19-18-30-90(86)92)182-135(222)98(45-49-117(160)206)176-152(239)123(77(5)6)192-145(232)105(58-82-26-14-12-15-27-82)180-136(223)99-46-50-119(208)164-54-25-22-34-93(131(218)168-78(7)128(215)169-97(134(221)174-99)44-48-116(159)205)170-132(219)94(32-20-23-52-155)171-150(237)113(72-197)189-144(231)110(66-122(212)213)184-139(226)102(57-76(3)4)177-140(227)103(60-84-35-39-88(202)40-36-84)179-133(220)95(33-21-24-53-156)172-149(236)112(71-196)188-141(228)104(61-85-37-41-89(203)42-38-85)181-143(230)109(65-121(210)211)185-151(238)114(73-198)190-154(241)126(81(10)201)194-146(233)106(59-83-28-16-13-17-29-83)186-153(240)125(80(9)200)191-120(209)69-166-130(217)96(43-47-115(158)204)173-148(235)111(70-195)187-129(216)91(157)63-87-68-163-74-167-87/h12-19,26-31,35-42,67-68,74-81,91,93-114,123-126,165,195-203H,20-25,32-34,43-66,69-73,155-157H2,1-11H3,(H2,158,204)(H2,159,205)(H2,160,206)(H2,161,207)(H2,162,214)(H,163,167)(H,164,208)(H,166,217)(H,168,218)(H,169,215)(H,170,219)(H,171,237)(H,172,236)(H,173,235)(H,174,221)(H,175,225)(H,176,239)(H,177,227)(H,178,229)(H,179,220)(H,180,223)(H,181,230)(H,182,222)(H,183,224)(H,184,226)(H,185,238)(H,186,240)(H,187,216)(H,188,228)(H,189,231)(H,190,241)(H,191,209)(H,192,232)(H,193,234)(H,194,233)(H,210,211)(H,212,213)/t78-,79-,80-,81-,91+,93-,94-,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105-,106+,107+,108+,109+,110+,111+,112+,113+,114+,123+,124+,125+,126+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 320n/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay


J Med Chem 43: 1714-22 (2000)


Article DOI: 10.1021/jm990559d
BindingDB Entry DOI: 10.7270/Q2XG9RVJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50087844
PNG
(CHEMBL266411 | c[ Lys12, Asp21] glucagon-NH2)
Show InChI InChI=1S/C153H224N44O47S/c1-72(2)52-97(134(227)177-96(47-51-245-11)133(226)185-104(60-115(158)210)144(237)196-121(76(8)202)124(159)217)180-138(231)103(58-83-64-168-89-29-19-18-28-87(83)89)184-132(225)95(43-46-114(157)209)178-149(242)120(74(5)6)195-142(235)101(54-79-24-14-12-15-25-79)183-139(232)105-61-116(211)165-48-21-20-30-90(130(223)181-99(56-81-33-37-85(205)38-34-81)136(229)179-98(53-73(3)4)135(228)187-107(63-119(215)216)141(234)192-110(69-200)147(240)175-92(32-23-50-167-153(162)163)129(222)173-91(31-22-49-166-152(160)161)128(221)171-75(7)125(218)172-94(131(224)186-105)42-45-113(156)208)174-146(239)109(68-199)191-137(230)100(57-82-35-39-86(206)40-36-82)182-140(233)106(62-118(213)214)188-148(241)111(70-201)193-151(244)123(78(10)204)197-143(236)102(55-80-26-16-13-17-27-80)189-150(243)122(77(9)203)194-117(212)66-169-127(220)93(41-44-112(155)207)176-145(238)108(67-198)190-126(219)88(154)59-84-65-164-71-170-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,168,198-206H,20-23,30-32,41-63,66-70,154H2,1-11H3,(H2,155,207)(H2,156,208)(H2,157,209)(H2,158,210)(H2,159,217)(H,164,170)(H,165,211)(H,169,220)(H,171,221)(H,172,218)(H,173,222)(H,174,239)(H,175,240)(H,176,238)(H,177,227)(H,178,242)(H,179,229)(H,180,231)(H,181,223)(H,182,233)(H,183,232)(H,184,225)(H,185,226)(H,186,224)(H,187,228)(H,188,241)(H,189,243)(H,190,219)(H,191,230)(H,192,234)(H,193,244)(H,194,212)(H,195,235)(H,196,237)(H,197,236)(H,213,214)(H,215,216)(H4,160,161,166)(H4,162,163,167)/t75-,76+,77+,78+,88-,90-,91+,92-,93-,94+,95-,96-,97-,98+,99-,100-,101+,102-,103-,104-,105+,106-,107-,108-,109+,110+,111-,120-,121-,122-,123-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 794n/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay


J Med Chem 43: 1714-22 (2000)


Article DOI: 10.1021/jm990559d
BindingDB Entry DOI: 10.7270/Q2XG9RVJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324722
PNG
((2S,4S,7S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S,...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H](CCNC(N)=N)C(N)=O
Show InChI InChI=1S/C151H226N38O49/c1-17-76(10)120(147(234)166-80(14)127(214)175-104(61-86-64-159-90-35-25-24-34-89(86)90)137(224)177-100(57-73(4)5)138(225)186-118(74(6)7)145(232)174-92(36-26-28-53-152)128(215)160-66-110(196)167-91(123(154)210)52-55-158-151(155)156)188-139(226)102(58-83-30-20-18-21-31-83)178-134(221)98(46-51-116(206)207)171-131(218)93(37-27-29-54-153)168-126(213)79(13)164-124(211)78(12)165-130(217)95(43-48-113(200)201)170-132(219)96(44-49-114(202)203)172-133(220)97(45-50-115(204)205)173-135(222)99(56-72(2)3)176-136(223)101(60-85-38-40-88(195)41-39-85)179-142(229)107(68-190)182-144(231)109(70-192)183-146(233)119(75(8)9)187-141(228)105(63-117(208)209)180-143(230)108(69-191)184-149(236)122(82(16)194)189-140(227)103(59-84-32-22-19-23-33-84)181-148(235)121(81(15)193)185-111(197)67-161-129(216)94(42-47-112(198)199)169-125(212)77(11)163-106(150(237)238)62-87-65-157-71-162-87/h18-25,30-35,38-41,64-65,71-82,91-109,118-122,159,163,190-195H,17,26-29,36-37,42-63,66-70,152-153H2,1-16H3,(H2,154,210)(H,157,162)(H,160,215)(H,161,216)(H,164,211)(H,165,217)(H,166,234)(H,167,196)(H,168,213)(H,169,212)(H,170,219)(H,171,218)(H,172,220)(H,173,222)(H,174,232)(H,175,214)(H,176,223)(H,177,224)(H,178,221)(H,179,229)(H,180,230)(H,181,235)(H,182,231)(H,183,233)(H,184,236)(H,185,197)(H,186,225)(H,187,228)(H,188,226)(H,189,227)(H,198,199)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H,237,238)(H4,155,156,158)/t76-,77-,78-,79-,80-,81+,82-,91+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,118-,119-,120-,121-,122-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324731
PNG
(CHEMBL1222074 | HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C149H225N39O46/c1-17-76(10)119(145(230)166-80(14)126(211)174-103(60-86-63-158-90-36-25-24-35-89(86)90)135(220)176-99(56-73(4)5)136(221)185-117(74(6)7)143(228)173-92(37-26-28-52-150)127(212)159-65-110(196)167-91(122(153)207)39-30-54-157-149(154)155)187-137(222)101(57-83-31-20-18-21-32-83)177-132(217)97(47-51-115(203)204)172-131(216)93(38-27-29-53-151)169-125(210)79(13)164-123(208)78(12)165-130(215)96(44-48-109(152)195)168-111(197)66-160-129(214)95(46-50-114(201)202)171-133(218)98(55-72(2)3)175-134(219)100(59-85-40-42-88(194)43-41-85)178-140(225)106(68-189)181-142(227)108(70-191)182-144(229)118(75(8)9)186-139(224)104(62-116(205)206)179-141(226)107(69-190)183-147(232)121(82(16)193)188-138(223)102(58-84-33-22-19-23-34-84)180-146(231)120(81(15)192)184-112(198)67-161-128(213)94(45-49-113(199)200)170-124(209)77(11)163-105(148(233)234)61-87-64-156-71-162-87/h18-25,31-36,40-43,63-64,71-82,91-108,117-121,158,163,189-194H,17,26-30,37-39,44-62,65-70,150-151H2,1-16H3,(H2,152,195)(H2,153,207)(H,156,162)(H,159,212)(H,160,214)(H,161,213)(H,164,208)(H,165,215)(H,166,230)(H,167,196)(H,168,197)(H,169,210)(H,170,209)(H,171,218)(H,172,216)(H,173,228)(H,174,211)(H,175,219)(H,176,220)(H,177,217)(H,178,225)(H,179,226)(H,180,231)(H,181,227)(H,182,229)(H,183,232)(H,184,198)(H,185,221)(H,186,224)(H,187,222)(H,188,223)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,233,234)(H4,154,155,157)/t76-,77-,78-,79-,80-,81+,82-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50301952
PNG
((3S,6S,9S,12S,15S,21S)-21-(2-((S)-2-amino-3-(1H-im...)
Show SMILES CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2ccccc2F)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc2ccc(cc2)-c2ccccc2C)C(N)=O)cc1
Show InChI InChI=1S/C76H95FN14O19/c1-9-45-32-50(110-8)26-27-52(45)47-24-20-44(21-25-47)31-57(68(103)83-56(65(79)100)30-43-18-22-46(23-19-43)51-16-12-10-14-40(51)2)84-69(104)58(34-62(98)99)85-70(105)59(38-92)86-71(106)63(41(3)93)89-74(109)76(7,35-48-15-11-13-17-53(48)77)91-72(107)64(42(4)94)88-60(95)37-81-67(102)55(28-29-61(96)97)87-73(108)75(5,6)90-66(101)54(78)33-49-36-80-39-82-49/h10-27,32,36,39,41-42,54-59,63-64,92-94H,9,28-31,33-35,37-38,78H2,1-8H3,(H2,79,100)(H,80,82)(H,81,102)(H,83,103)(H,84,104)(H,85,105)(H,86,106)(H,87,108)(H,88,95)(H,89,109)(H,90,101)(H,91,107)(H,96,97)(H,98,99)/t41-,42-,54+,55+,56+,57+,58+,59+,63+,64+,76+/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Company Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at glucagon receptor


J Med Chem 52: 7788-99 (2009)


Article DOI: 10.1021/jm900752a
BindingDB Entry DOI: 10.7270/Q2VH5PRK
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50044849
PNG
(CHEMBL3311308)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H19NO3S/c1-11-9-12(2)16(13(3)10-11)17-21(18,19)15-7-5-14(20-4)6-8-15/h5-10,17H,1-4H3
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n/an/an/an/a<5.01E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human glucagon receptor expressed in CHO cells by luciferase HTS/summary (Abse5) assay


Bioorg Med Chem Lett 24: 3100-3 (2014)


Article DOI: 10.1016/j.bmcl.2014.05.012
BindingDB Entry DOI: 10.7270/Q2CC1292
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50144020
PNG
(3-{4-[1-(4-Benzofuran-2-yl-phenylcarbamoyl)-heptyl...)
Show SMILES CCCCCCC(Oc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1cc2ccccc2o1
Show InChI InChI=1S/C32H34N2O6/c1-2-3-4-5-10-28(39-26-17-13-23(14-18-26)31(37)33-20-19-30(35)36)32(38)34-25-15-11-22(12-16-25)29-21-24-8-6-7-9-27(24)40-29/h6-9,11-18,21,28H,2-5,10,19-20H2,1H3,(H,33,37)(H,34,38)(H,35,36)
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3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against human glucagon receptor (h-GlucR) was determined


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50360584
PNG
(CHEMBL1933350)
Show SMILES CCC[C@@H]([C@@H](c1c[nH]c2c(F)cc(C)cc12)c1ccc(Cl)cc1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C30H30ClFN2O3/c1-3-4-23(19-5-7-21(8-6-19)30(37)33-14-13-27(35)36)28(20-9-11-22(31)12-10-20)25-17-34-29-24(25)15-18(2)16-26(29)32/h5-12,15-17,23,28,34H,3-4,13-14H2,1-2H3,(H,33,37)(H,35,36)/t23-,28+/m1/s1
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4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]Glucagon-Cex from human GCGR


Bioorg Med Chem Lett 22: 415-20 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.113
BindingDB Entry DOI: 10.7270/Q2H70G82
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50144008
PNG
(3-{4-[2-(4-Benzofuran-2-yl-phenylcarbamoyl)-2-(4-t...)
Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1cc2ccccc2o1
Show InChI InChI=1S/C37H36N2O5/c1-37(2,3)29-16-12-25(13-17-29)31(22-24-8-10-27(11-9-24)35(42)38-21-20-34(40)41)36(43)39-30-18-14-26(15-19-30)33-23-28-6-4-5-7-32(28)44-33/h4-19,23,31H,20-22H2,1-3H3,(H,38,42)(H,39,43)(H,40,41)
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4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against human glucagon receptor (h-GlucR) was determined


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Glucagon


(Homo sapiens (Human))
BDBM2437
PNG
(US8507533, 157)
Show SMILES CC1(C)CC(C1)C(Nc1cnc(nc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H27F3N6O3/c1-24(2)9-17(10-24)21(15-3-5-16(6-4-15)22(37)29-8-7-20(35)36)33-19-12-30-23(31-13-19)34-14-18(11-32-34)25(26,27)28/h3-6,11-14,17,21,33H,7-10H2,1-2H3,(H,29,37)(H,35,36)
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5.55n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors.


US Patent US8507533 (2013)


BindingDB Entry DOI: 10.7270/Q23R0RGH
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM2437
PNG
(US8507533, 157)
Show SMILES CC1(C)CC(C1)C(Nc1cnc(nc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H27F3N6O3/c1-24(2)9-17(10-24)21(15-3-5-16(6-4-15)22(37)29-8-7-20(35)36)33-19-12-30-23(31-13-19)34-14-18(11-32-34)25(26,27)28/h3-6,11-14,17,21,33H,7-10H2,1-2H3,(H,29,37)(H,35,36)
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5.60n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in Chem-1 cell membranes after 6 to 10 hrs by scintillation proximity assay


Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon


(Homo sapiens (Human))
BDBM100827
PNG
(US8507533, 138 | US8507533, 151 | US8507533, 374)
Show SMILES Cc1cc(OC(C2CCC2)c2ccc(cc2)C(=O)NCCC(O)=O)cc(C)c1-n1cc(cn1)C(F)(F)F
Show InChI InChI=1S/C27H28F3N3O4/c1-16-12-22(13-17(2)24(16)33-15-21(14-32-33)27(28,29)30)37-25(18-4-3-5-18)19-6-8-20(9-7-19)26(36)31-11-10-23(34)35/h6-9,12-15,18,25H,3-5,10-11H2,1-2H3,(H,31,36)(H,34,35)
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5.75n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors.


US Patent US8507533 (2013)


BindingDB Entry DOI: 10.7270/Q23R0RGH
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50144015
PNG
(3-{4-[2-(4-Benzofuran-2-yl-phenylcarbamoyl)-octyl]...)
Show SMILES CCCCCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1cc2ccccc2o1
Show InChI InChI=1S/C33H36N2O5/c1-2-3-4-5-9-27(21-23-11-13-25(14-12-23)32(38)34-20-19-31(36)37)33(39)35-28-17-15-24(16-18-28)30-22-26-8-6-7-10-29(26)40-30/h6-8,10-18,22,27H,2-5,9,19-21H2,1H3,(H,34,38)(H,35,39)(H,36,37)
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6n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against human glucagon receptor (h-GlucR) was determined


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50144002
PNG
(3-{4-[2-(4-tert-Butyl-phenyl)-2-(2',4'-dichloro-bi...)
Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C35H34Cl2N2O4/c1-35(2,3)26-12-8-24(9-13-26)30(20-22-4-6-25(7-5-22)33(42)38-19-18-32(40)41)34(43)39-28-15-10-23(11-16-28)29-17-14-27(36)21-31(29)37/h4-17,21,30H,18-20H2,1-3H3,(H,38,42)(H,39,43)(H,40,41)
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6n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against human glucagon receptor (h-GlucR) was determined


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50144001
PNG
(3-{4-[1-(2',4'-Dichloro-biphenyl-4-ylcarbamoyl)-he...)
Show SMILES CCCCCCC(Oc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C30H32Cl2N2O5/c1-2-3-4-5-6-27(39-24-14-9-21(10-15-24)29(37)33-18-17-28(35)36)30(38)34-23-12-7-20(8-13-23)25-16-11-22(31)19-26(25)32/h7-16,19,27H,2-6,17-18H2,1H3,(H,33,37)(H,34,38)(H,35,36)
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6n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against human glucagon receptor (h-GlucR) was determined


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Glucagon


(Homo sapiens (Human))
BDBM100806
PNG
(US8507533, 114 | US8507533, 115 | US8507533, 330)
Show SMILES CC1(C)CC(C1)C(Nc1ccc(nc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C26H28F3N5O3/c1-25(2)11-18(12-25)23(16-3-5-17(6-4-16)24(37)30-10-9-22(35)36)33-20-7-8-21(31-14-20)34-15-19(13-32-34)26(27,28)29/h3-8,13-15,18,23,33H,9-12H2,1-2H3,(H,30,37)(H,35,36)
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7.60n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors.


US Patent US8507533 (2013)


BindingDB Entry DOI: 10.7270/Q23R0RGH
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50144016
PNG
(3-{4-[(Biphenyl-4-ylcarbamoyl)-(4-tert-butyl-pheny...)
Show SMILES CC(C)(C)c1ccc(cc1)C(Oc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C34H34N2O5/c1-34(2,3)27-15-9-25(10-16-27)31(41-29-19-13-26(14-20-29)32(39)35-22-21-30(37)38)33(40)36-28-17-11-24(12-18-28)23-7-5-4-6-8-23/h4-20,31H,21-22H2,1-3H3,(H,35,39)(H,36,40)(H,37,38)
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9n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against human glucagon receptor (h-GlucR) was determined


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
Glucagon


(Homo sapiens (Human))
BDBM2390
PNG
(US8507533, 146)
Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)[C@@H](Nc1ccc(nc1)-n1cc(cn1)C(F)(F)F)C1CCCCC1
Show InChI InChI=1S/C26H28F3N5O3/c27-26(28,29)20-14-32-34(16-20)22-11-10-21(15-31-22)33-24(17-4-2-1-3-5-17)18-6-8-19(9-7-18)25(37)30-13-12-23(35)36/h6-11,14-17,24,33H,1-5,12-13H2,(H,30,37)(H,35,36)/t24-/m0/s1
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9.05n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors.


US Patent US8507533 (2013)


BindingDB Entry DOI: 10.7270/Q23R0RGH
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50144006
PNG
(3-{4-[2-(4-tert-Butyl-phenyl)-2-(quinolin-3-ylcarb...)
Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C32H33N3O4/c1-32(2,3)25-14-12-22(13-15-25)27(31(39)35-26-19-24-6-4-5-7-28(24)34-20-26)18-21-8-10-23(11-9-21)30(38)33-17-16-29(36)37/h4-15,19-20,27H,16-18H2,1-3H3,(H,33,38)(H,35,39)(H,36,37)
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11n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against human glucagon receptor (h-GlucR) was determined


Bioorg Med Chem Lett 14: 2047-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH
More data for this
Ligand-Target Pair
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