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Compile Data Set for Download or QSAR

Found 1033 hits Enz. Inhib. hit(s) with Target = 'Glucagon-like peptide 1 receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273759
PNG
((3S,6S,9S,12S,15S,21S)-3-((S)-1-((S)-1-((2S,5S,8S,...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C155H235N41O45/c1-17-80(10)124(152(239)188-107(63-87-33-20-18-21-34-87)141(228)173-84(14)131(218)183-110(66-90-69-166-95-38-25-24-37-93(90)95)144(231)185-106(62-77(4)5)145(232)193-122(78(6)7)150(237)182-97(39-26-29-57-156)133(220)167-71-116(204)174-96(127(160)214)42-32-60-165-155(161)162)195-140(227)104(51-56-120(210)211)180-136(223)98(40-27-30-58-157)175-129(216)82(12)170-128(215)81(11)172-135(222)101(47-52-114(159)202)178-138(225)102-48-53-115(203)164-59-31-28-41-99(137(224)186-108(65-89-43-45-92(201)46-44-89)143(230)184-105(61-76(2)3)142(229)181-103(139(226)179-102)50-55-119(208)209)177-148(235)112(73-197)190-151(238)123(79(8)9)194-147(234)111(68-121(212)213)187-149(236)113(74-198)191-154(241)126(86(16)200)196-146(233)109(64-88-35-22-19-23-36-88)189-153(240)125(85(15)199)192-117(205)72-168-134(221)100(49-54-118(206)207)176-130(217)83(13)171-132(219)94(158)67-91-70-163-75-169-91/h18-25,33-38,43-46,69-70,75-86,94,96-113,122-126,166,197-201H,17,26-32,39-42,47-68,71-74,156-158H2,1-16H3,(H2,159,202)(H2,160,214)(H,163,169)(H,164,203)(H,167,220)(H,168,221)(H,170,215)(H,171,219)(H,172,222)(H,173,228)(H,174,204)(H,175,216)(H,176,217)(H,177,235)(H,178,225)(H,179,226)(H,180,223)(H,181,229)(H,182,237)(H,183,218)(H,184,230)(H,185,231)(H,186,224)(H,187,236)(H,188,239)(H,189,240)(H,190,238)(H,191,241)(H,192,205)(H,193,232)(H,194,234)(H,195,227)(H,196,233)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,161,162,165)/t80-,81-,82-,83-,84-,85+,86+,94-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-,126-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.00199n/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Activation of human GLP1R expressed in HEK293 cells assessed as effect on cAMP responsive element promoter driven luciferase expression


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273767
PNG
((4S,7S,10S,13S,16S,22S,25S,28S,31S,34S,37S,40S,43S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C151H226N40O46/c1-16-77(10)121(148(235)182-103(58-83-30-19-17-20-31-83)137(224)173-94-37-26-28-54-159-111(199)49-44-95(129(216)162-66-112(200)169-92(124(155)211)38-29-55-160-151(156)157)176-146(233)119(75(6)7)188-140(227)101(57-74(4)5)178-139(226)105(180-134(94)221)61-86-64-161-91-35-24-23-34-89(86)91)190-135(222)99(47-52-117(207)208)175-133(220)93(36-25-27-53-152)171-126(213)79(12)166-125(212)78(11)168-132(219)98(43-48-110(154)198)170-113(201)67-163-131(218)97(46-51-116(205)206)174-136(223)100(56-73(2)3)177-138(225)102(60-85-39-41-88(197)42-40-85)179-143(230)107(69-192)184-145(232)109(71-194)185-147(234)120(76(8)9)189-142(229)106(63-118(209)210)181-144(231)108(70-193)186-150(237)123(82(15)196)191-141(228)104(59-84-32-21-18-22-33-84)183-149(236)122(81(14)195)187-114(202)68-164-130(217)96(45-50-115(203)204)172-127(214)80(13)167-128(215)90(153)62-87-65-158-72-165-87/h17-24,30-35,39-42,64-65,72-82,90,92-109,119-123,161,192-197H,16,25-29,36-38,43-63,66-71,152-153H2,1-15H3,(H2,154,198)(H2,155,211)(H,158,165)(H,159,199)(H,162,216)(H,163,218)(H,164,217)(H,166,212)(H,167,215)(H,168,219)(H,169,200)(H,170,201)(H,171,213)(H,172,214)(H,173,224)(H,174,223)(H,175,220)(H,176,233)(H,177,225)(H,178,226)(H,179,230)(H,180,221)(H,181,231)(H,182,235)(H,183,236)(H,184,232)(H,185,234)(H,186,237)(H,187,202)(H,188,227)(H,189,229)(H,190,222)(H,191,228)(H,203,204)(H,205,206)(H,207,208)(H,209,210)(H4,156,157,160)/t77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,119-,120-,121-,122-,123-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.00209n/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Activation of human GLP1R expressed in HEK293 cells assessed as effect on cAMP responsive element promoter driven luciferase expression


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273766
PNG
((4S,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,40S)-4-...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C152H233N41O44/c1-18-79(10)122(149(235)184-105(60-87-34-21-19-22-35-87)137(223)171-83(14)129(215)179-108(63-90-66-163-95-39-26-25-38-93(90)95)140(226)181-104(59-76(4)5)141(227)190-120(77(6)7)147(233)178-97(40-27-30-54-153)131(217)164-68-114(202)172-96(125(157)211)43-33-57-162-152(158)159)192-136(222)102(48-51-113(156)201)177-135(221)99(41-28-31-55-154)174-127(213)81(12)168-126(212)80(11)170-134(220)98(42-29-32-56-161-86(17)199)173-115(203)69-165-133(219)101(50-53-118(207)208)176-138(224)103(58-75(2)3)180-139(225)106(62-89-44-46-92(200)47-45-89)182-144(230)110(71-194)186-146(232)112(73-196)187-148(234)121(78(8)9)191-143(229)109(65-119(209)210)183-145(231)111(72-195)188-151(237)124(85(16)198)193-142(228)107(61-88-36-23-20-24-37-88)185-150(236)123(84(15)197)189-116(204)70-166-132(218)100(49-52-117(205)206)175-128(214)82(13)169-130(216)94(155)64-91-67-160-74-167-91/h19-26,34-39,44-47,66-67,74-85,94,96-112,120-124,163,194-198,200H,18,27-33,40-43,48-65,68-73,153-155H2,1-17H3,(H2,156,201)(H2,157,211)(H,160,167)(H,161,199)(H,164,217)(H,165,219)(H,166,218)(H,168,212)(H,169,216)(H,170,220)(H,171,223)(H,172,202)(H,173,203)(H,174,213)(H,175,214)(H,176,224)(H,177,221)(H,178,233)(H,179,215)(H,180,225)(H,181,226)(H,182,230)(H,183,231)(H,184,235)(H,185,236)(H,186,232)(H,187,234)(H,188,237)(H,189,204)(H,190,227)(H,191,229)(H,192,222)(H,193,228)(H,205,206)(H,207,208)(H,209,210)(H4,158,159,162)/t79-,80-,81-,82-,83-,84+,85+,94-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,120-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.00282n/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Activation of human GLP1R expressed in HEK293 cells assessed as effect on cAMP responsive element promoter driven luciferase expression


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273765
PNG
((4S,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,40S)-4-...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C150H228N40O43/c1-17-78(10)120(147(231)181-103(59-85-33-20-18-21-34-85)135(219)168-82(14)127(211)176-106(62-88-65-160-93-38-25-24-37-91(88)93)138(222)178-102(58-75(4)5)139(223)187-118(76(6)7)145(229)175-95(39-26-29-53-151)129(213)161-67-112(198)169-94(123(154)207)42-32-56-159-150(155)156)189-134(218)100-47-50-111(197)158-55-31-28-41-96(132(216)167-79(11)124(208)165-80(12)125(209)171-97(133(217)174-100)40-27-30-54-152)170-113(199)68-162-131(215)99(49-52-116(203)204)173-136(220)101(57-74(2)3)177-137(221)104(61-87-43-45-90(196)46-44-87)179-142(226)108(70-191)183-144(228)110(72-193)184-146(230)119(77(8)9)188-141(225)107(64-117(205)206)180-143(227)109(71-192)185-149(233)122(84(16)195)190-140(224)105(60-86-35-22-19-23-36-86)182-148(232)121(83(15)194)186-114(200)69-163-130(214)98(48-51-115(201)202)172-126(210)81(13)166-128(212)92(153)63-89-66-157-73-164-89/h18-25,33-38,43-46,65-66,73-84,92,94-110,118-122,160,191-196H,17,26-32,39-42,47-64,67-72,151-153H2,1-16H3,(H2,154,207)(H,157,164)(H,158,197)(H,161,213)(H,162,215)(H,163,214)(H,165,208)(H,166,212)(H,167,216)(H,168,219)(H,169,198)(H,170,199)(H,171,209)(H,172,210)(H,173,220)(H,174,217)(H,175,229)(H,176,211)(H,177,221)(H,178,222)(H,179,226)(H,180,227)(H,181,231)(H,182,232)(H,183,228)(H,184,230)(H,185,233)(H,186,200)(H,187,223)(H,188,225)(H,189,218)(H,190,224)(H,201,202)(H,203,204)(H,205,206)(H4,155,156,159)/t78-,79-,80-,81-,82-,83+,84+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,118-,119-,120-,121-,122-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.00288n/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Activation of human GLP1R expressed in HEK293 cells assessed as effect on cAMP responsive element promoter driven luciferase expression


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50261508
PNG
(CHEMBL525934 | [Gly8,Glu22]GLP-1(7,37)-NH2)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O
Show InChI InChI=1S/C153H230N40O49/c1-16-78(10)123(150(240)170-81(13)128(218)179-106(61-87-64-162-92-35-24-23-34-90(87)92)140(230)181-102(57-75(4)5)141(231)190-121(76(6)7)148(238)178-94(36-25-27-53-154)131(221)164-67-113(202)171-93(38-29-55-161-153(158)159)130(220)166-69-120(214)215)192-142(232)104(58-84-30-19-17-20-31-84)182-137(227)100(47-52-118(210)211)175-134(224)95(37-26-28-54-155)173-127(217)80(12)168-126(216)79(11)169-133(223)97(43-48-111(157)200)174-135(225)98(45-50-116(206)207)176-136(226)99(46-51-117(208)209)177-138(228)101(56-74(2)3)180-139(229)103(60-86-39-41-89(199)42-40-86)183-145(235)108(70-194)186-147(237)110(72-196)187-149(239)122(77(8)9)191-144(234)107(63-119(212)213)184-146(236)109(71-195)188-152(242)125(83(15)198)193-143(233)105(59-85-32-21-18-22-33-85)185-151(241)124(82(14)197)189-114(203)68-165-132(222)96(44-49-115(204)205)172-112(201)66-163-129(219)91(156)62-88-65-160-73-167-88/h17-24,30-35,39-42,64-65,73-83,91,93-110,121-125,162,194-199H,16,25-29,36-38,43-63,66-72,154-156H2,1-15H3,(H2,157,200)(H,160,167)(H,163,219)(H,164,221)(H,165,222)(H,166,220)(H,168,216)(H,169,223)(H,170,240)(H,171,202)(H,172,201)(H,173,217)(H,174,225)(H,175,224)(H,176,226)(H,177,228)(H,178,238)(H,179,218)(H,180,229)(H,181,230)(H,182,227)(H,183,235)(H,184,236)(H,185,241)(H,186,237)(H,187,239)(H,188,242)(H,189,203)(H,190,231)(H,191,234)(H,192,232)(H,193,233)(H,204,205)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H4,158,159,161)/t78-,79-,80-,81-,82+,83+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,121-,122-,123-,124-,125-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.00300n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as increase in cAMP level by cAMP-response element/luciferase activation assay


J Med Chem 51: 2758-65 (2008)


Article DOI: 10.1021/jm701522b
BindingDB Entry DOI: 10.7270/Q2736QPR
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273771
PNG
((4S,7S,10S,13S,16S,22S)-4-((2S,3S)-1-((S)-1-((2S,5...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C151H223N41O47/c1-12-76(6)121(148(237)184-103(59-82-28-15-13-16-29-82)139(228)174-93-35-22-25-55-159-111(200)49-43-95(129(218)163-67-113(202)170-91(124(155)213)37-27-57-161-151(156)157)179-147(236)120(75(4)5)190-142(231)101(58-74(2)3)180-140(229)105(182-134(93)223)62-85-65-162-90-33-20-19-32-88(85)90)191-137(226)100(47-53-118(209)210)177-133(222)92(34-21-24-54-152)172-126(215)78(8)167-125(214)77(7)169-132(221)98(42-48-110(154)199)171-114(203)68-164-131(220)97(46-52-117(207)208)176-136(225)99-44-50-112(201)160-56-26-23-36-94(135(224)186-108(71-194)146(235)187-107(70-193)144(233)181-102(138(227)178-99)61-84-38-40-87(198)41-39-84)175-141(230)106(64-119(211)212)183-145(234)109(72-195)188-150(239)123(81(11)197)192-143(232)104(60-83-30-17-14-18-31-83)185-149(238)122(80(10)196)189-115(204)69-165-130(219)96(45-51-116(205)206)173-127(216)79(9)168-128(217)89(153)63-86-66-158-73-166-86/h13-20,28-33,38-41,65-66,73-81,89,91-109,120-123,162,193-198H,12,21-27,34-37,42-64,67-72,152-153H2,1-11H3,(H2,154,199)(H2,155,213)(H,158,166)(H,159,200)(H,160,201)(H,163,218)(H,164,220)(H,165,219)(H,167,214)(H,168,217)(H,169,221)(H,170,202)(H,171,203)(H,172,215)(H,173,216)(H,174,228)(H,175,230)(H,176,225)(H,177,222)(H,178,227)(H,179,236)(H,180,229)(H,181,233)(H,182,223)(H,183,234)(H,184,237)(H,185,238)(H,186,224)(H,187,235)(H,188,239)(H,189,204)(H,190,231)(H,191,226)(H,192,232)(H,205,206)(H,207,208)(H,209,210)(H,211,212)(H4,156,157,161)/t76-,77-,78-,79-,80+,81+,89-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,120-,121-,122-,123-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.00331n/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Activation of human GLP1R expressed in HEK293 cells assessed as effect on cAMP responsive element promoter driven luciferase expression


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273752
PNG
(CHEMBL503836 | HAEGTFTSDVSSYLEGQAAKEIFAWLVKGR)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C149H225N39O46/c1-17-76(10)119(145(230)179-101(57-83-31-20-18-21-32-83)133(218)166-80(14)125(210)174-104(60-86-63-158-91-36-25-24-35-89(86)91)136(221)176-100(56-73(4)5)137(222)185-117(74(6)7)143(228)173-92(37-26-28-52-150)127(212)159-66-111(197)168-98(148(233)234)39-30-54-157-149(154)155)187-132(217)97(47-51-115(203)204)172-131(216)93(38-27-29-53-151)169-123(208)78(12)163-122(207)77(11)165-130(215)96(44-48-109(153)195)167-110(196)65-160-129(214)95(46-50-114(201)202)171-134(219)99(55-72(2)3)175-135(220)102(59-85-40-42-88(194)43-41-85)177-140(225)106(68-189)181-142(227)108(70-191)182-144(229)118(75(8)9)186-139(224)105(62-116(205)206)178-141(226)107(69-190)183-147(232)121(82(16)193)188-138(223)103(58-84-33-22-19-23-34-84)180-146(231)120(81(15)192)184-112(198)67-161-128(213)94(45-49-113(199)200)170-124(209)79(13)164-126(211)90(152)61-87-64-156-71-162-87/h18-25,31-36,40-43,63-64,71-82,90,92-108,117-121,158,189-194H,17,26-30,37-39,44-62,65-70,150-152H2,1-16H3,(H2,153,195)(H,156,162)(H,159,212)(H,160,214)(H,161,213)(H,163,207)(H,164,211)(H,165,215)(H,166,218)(H,167,196)(H,168,197)(H,169,208)(H,170,209)(H,171,219)(H,172,216)(H,173,228)(H,174,210)(H,175,220)(H,176,221)(H,177,225)(H,178,226)(H,179,230)(H,180,231)(H,181,227)(H,182,229)(H,183,232)(H,184,198)(H,185,222)(H,186,224)(H,187,217)(H,188,223)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,233,234)(H4,154,155,157)/t76-,77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.00360n/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Activation of human GLP1R expressed in HEK293 cells assessed as effect on cAMP responsive element promoter driven luciferase expression


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273760
PNG
((4S,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C157H240N42O46/c1-18-81(10)126(154(243)191-109(64-89-34-21-19-22-35-89)143(232)176-85(14)133(222)186-112(67-92-70-169-97-39-26-25-38-95(92)97)146(235)188-108(63-78(4)5)147(236)196-124(79(6)7)152(241)185-99(40-27-30-58-158)135(224)170-72-118(208)177-98(129(163)218)43-33-61-168-157(164)165)198-142(231)106(52-57-122(214)215)183-138(227)100(41-28-31-59-159)178-131(220)83(12)173-130(219)82(11)175-137(226)103(48-53-116(161)206)181-140(229)104(49-54-117(162)207)182-141(230)105(51-56-121(212)213)184-144(233)107(62-77(2)3)187-145(234)110(66-91-44-46-94(205)47-45-91)189-139(228)101(42-29-32-60-167-88(17)204)180-150(239)114(74-200)193-153(242)125(80(8)9)197-149(238)113(69-123(216)217)190-151(240)115(75-201)194-156(245)128(87(16)203)199-148(237)111(65-90-36-23-20-24-37-90)192-155(244)127(86(15)202)195-119(209)73-171-136(225)102(50-55-120(210)211)179-132(221)84(13)174-134(223)96(160)68-93-71-166-76-172-93/h19-26,34-39,44-47,70-71,76-87,96,98-115,124-128,169,200-203,205H,18,27-33,40-43,48-69,72-75,158-160H2,1-17H3,(H2,161,206)(H2,162,207)(H2,163,218)(H,166,172)(H,167,204)(H,170,224)(H,171,225)(H,173,219)(H,174,223)(H,175,226)(H,176,232)(H,177,208)(H,178,220)(H,179,221)(H,180,239)(H,181,229)(H,182,230)(H,183,227)(H,184,233)(H,185,241)(H,186,222)(H,187,234)(H,188,235)(H,189,228)(H,190,240)(H,191,243)(H,192,244)(H,193,242)(H,194,245)(H,195,209)(H,196,236)(H,197,238)(H,198,231)(H,199,237)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H4,164,165,168)/t81-,82-,83-,84-,85-,86+,87+,96-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,124-,125-,126-,127-,128-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.00380n/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Activation of human GLP1R expressed in HEK293 cells assessed as effect on cAMP responsive element promoter driven luciferase expression


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50261522
PNG
(CHEMBL507645 | c[hGlu22-Lys26][Gly8]GLP-1(7-37)-NH...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc2c[nH]cn2)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C154H231N41O47/c1-16-79(10)124(151(240)172-82(13)129(218)181-107(62-88-65-164-93-36-24-23-35-91(88)93)141(230)183-103(58-76(4)5)142(231)192-122(77(6)7)149(238)180-95(37-25-27-54-155)132(221)167-69-116(206)173-94(40-30-56-163-154(159)160)131(220)165-67-113(158)203)194-143(232)105(59-85-31-19-17-20-32-85)184-138(227)101(49-53-120(212)213)178-135(224)96-38-26-28-55-162-114(204)41-29-39-97(136(225)177-99(46-50-112(157)202)134(223)171-80(11)127(216)170-81(12)128(217)175-96)176-137(226)100(48-52-119(210)211)179-139(228)102(57-75(2)3)182-140(229)104(61-87-42-44-90(201)45-43-87)185-146(235)109(71-196)188-148(237)111(73-198)189-150(239)123(78(8)9)193-145(234)108(64-121(214)215)186-147(236)110(72-197)190-153(242)126(84(15)200)195-144(233)106(60-86-33-21-18-22-34-86)187-152(241)125(83(14)199)191-117(207)70-168-133(222)98(47-51-118(208)209)174-115(205)68-166-130(219)92(156)63-89-66-161-74-169-89/h17-24,31-36,42-45,65-66,74-84,92,94-111,122-126,164,196-201H,16,25-30,37-41,46-64,67-73,155-156H2,1-15H3,(H2,157,202)(H2,158,203)(H,161,169)(H,162,204)(H,165,220)(H,166,219)(H,167,221)(H,168,222)(H,170,216)(H,171,223)(H,172,240)(H,173,206)(H,174,205)(H,175,217)(H,176,226)(H,177,225)(H,178,224)(H,179,228)(H,180,238)(H,181,218)(H,182,229)(H,183,230)(H,184,227)(H,185,235)(H,186,236)(H,187,241)(H,188,237)(H,189,239)(H,190,242)(H,191,207)(H,192,231)(H,193,234)(H,194,232)(H,195,233)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H4,159,160,163)/t79-,80-,81-,82-,83-,84-,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,122-,123-,124-,125-,126-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.00400n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as increase in cAMP level by cAMP-response element/luciferase activation assay


J Med Chem 51: 2758-65 (2008)


Article DOI: 10.1021/jm701522b
BindingDB Entry DOI: 10.7270/Q2736QPR
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50241203
PNG
(CHEMBL414357 | HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGS...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C184H282N50O60S/c1-16-94(10)147(178(289)213-114(52-58-144(257)258)163(274)218-121(73-101-77-195-105-39-24-23-38-103(101)105)168(279)215-116(68-90(2)3)165(276)205-107(41-26-28-61-186)158(269)219-122(75-134(189)243)154(265)198-79-135(244)196-83-139(248)231-63-30-43-129(231)175(286)225-127(87-238)174(285)223-125(85-236)155(266)200-80-136(245)202-96(12)181(292)233-65-32-45-131(233)183(294)234-66-33-46-132(234)182(293)232-64-31-44-130(232)176(287)222-124(84-235)150(190)261)229-170(281)119(71-99-34-19-17-20-35-99)217-166(277)117(69-91(4)5)214-159(270)108(42-29-62-194-184(191)192)212-177(288)146(93(8)9)228-151(262)95(11)203-156(267)111(49-55-141(251)252)208-161(272)112(50-56-142(253)254)209-162(273)113(51-57-143(255)256)210-164(275)115(59-67-295-15)211-160(271)110(47-53-133(188)242)207-157(268)106(40-25-27-60-185)206-172(283)126(86-237)224-167(278)118(70-92(6)7)216-169(280)123(76-145(259)260)220-173(284)128(88-239)226-180(291)149(98(14)241)230-171(282)120(72-100-36-21-18-22-37-100)221-179(290)148(97(13)240)227-138(247)82-199-153(264)109(48-54-140(249)250)204-137(246)81-197-152(263)104(187)74-102-78-193-89-201-102/h17-24,34-39,77-78,89-98,104,106-132,146-149,195,235-241H,16,25-33,40-76,79-88,185-187H2,1-15H3,(H2,188,242)(H2,189,243)(H2,190,261)(H,193,201)(H,196,244)(H,197,263)(H,198,265)(H,199,264)(H,200,266)(H,202,245)(H,203,267)(H,204,246)(H,205,276)(H,206,283)(H,207,268)(H,208,272)(H,209,273)(H,210,275)(H,211,271)(H,212,288)(H,213,289)(H,214,270)(H,215,279)(H,216,280)(H,217,277)(H,218,274)(H,219,269)(H,220,284)(H,221,290)(H,222,287)(H,223,285)(H,224,278)(H,225,286)(H,226,291)(H,227,247)(H,228,262)(H,229,281)(H,230,282)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,191,192,194)/t94-,95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.00400n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as increase in cAMP level by cAMP-response element/luciferase activation assay


J Med Chem 51: 2758-65 (2008)


Article DOI: 10.1021/jm701522b
BindingDB Entry DOI: 10.7270/Q2736QPR
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273768
PNG
((4S,7S,10S,13S,16S,22S,25S,28S,31S,34S,37S,40S,43S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C153H231N41O47/c1-17-78(10)123(150(239)185-105(59-85-31-20-18-21-32-85)139(228)176-96(38-27-29-55-162-84(16)200)136(225)183-107(62-88-65-164-93-36-25-24-35-91(88)93)141(230)181-103(58-75(4)5)142(231)191-121(76(6)7)148(237)179-97(44-49-112(156)202)131(220)165-67-114(204)172-94(126(158)215)39-30-56-163-153(159)160)193-137(226)101(48-53-119(211)212)178-135(224)95(37-26-28-54-154)174-128(217)80(12)169-127(216)79(11)171-134(223)100(45-50-113(157)203)173-115(205)68-166-133(222)99(47-52-118(209)210)177-138(227)102(57-74(2)3)180-140(229)104(61-87-40-42-90(201)43-41-87)182-145(234)109(70-195)187-147(236)111(72-197)188-149(238)122(77(8)9)192-144(233)108(64-120(213)214)184-146(235)110(71-196)189-152(241)125(83(15)199)194-143(232)106(60-86-33-22-19-23-34-86)186-151(240)124(82(14)198)190-116(206)69-167-132(221)98(46-51-117(207)208)175-129(218)81(13)170-130(219)92(155)63-89-66-161-73-168-89/h18-25,31-36,40-43,65-66,73-83,92,94-111,121-125,164,195-199,201H,17,26-30,37-39,44-64,67-72,154-155H2,1-16H3,(H2,156,202)(H2,157,203)(H2,158,215)(H,161,168)(H,162,200)(H,165,220)(H,166,222)(H,167,221)(H,169,216)(H,170,219)(H,171,223)(H,172,204)(H,173,205)(H,174,217)(H,175,218)(H,176,228)(H,177,227)(H,178,224)(H,179,237)(H,180,229)(H,181,230)(H,182,234)(H,183,225)(H,184,235)(H,185,239)(H,186,240)(H,187,236)(H,188,238)(H,189,241)(H,190,206)(H,191,231)(H,192,233)(H,193,226)(H,194,232)(H,207,208)(H,209,210)(H,211,212)(H,213,214)(H4,159,160,163)/t78-,79-,80-,81-,82+,83+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-,125-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.00479n/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Activation of human GLP1R expressed in HEK293 cells assessed as effect on cAMP responsive element promoter driven luciferase expression


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50261506
PNG
(CHEMBL499930 | HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG-NH2)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C151H229N41O46/c1-17-77(10)121(148(236)170-81(14)127(215)178-105(60-87-63-161-92-36-25-24-35-90(87)92)138(226)180-101(56-74(4)5)139(227)189-119(75(6)7)146(234)177-94(37-26-28-52-152)130(218)163-66-112(201)171-93(39-30-54-160-151(157)158)129(217)162-65-111(156)200)191-140(228)103(57-84-31-20-18-21-32-84)181-135(223)99(47-51-117(208)209)176-134(222)95(38-27-29-53-153)173-125(213)79(12)167-124(212)78(11)169-133(221)98(44-48-110(155)199)172-113(202)67-164-132(220)97(46-50-116(206)207)175-136(224)100(55-73(2)3)179-137(225)102(59-86-40-42-89(198)43-41-86)182-143(231)107(69-193)185-145(233)109(71-195)186-147(235)120(76(8)9)190-142(230)106(62-118(210)211)183-144(232)108(70-194)187-150(238)123(83(16)197)192-141(229)104(58-85-33-22-19-23-34-85)184-149(237)122(82(15)196)188-114(203)68-165-131(219)96(45-49-115(204)205)174-126(214)80(13)168-128(216)91(154)61-88-64-159-72-166-88/h18-25,31-36,40-43,63-64,72-83,91,93-109,119-123,161,193-198H,17,26-30,37-39,44-62,65-71,152-154H2,1-16H3,(H2,155,199)(H2,156,200)(H,159,166)(H,162,217)(H,163,218)(H,164,220)(H,165,219)(H,167,212)(H,168,216)(H,169,221)(H,170,236)(H,171,201)(H,172,202)(H,173,213)(H,174,214)(H,175,224)(H,176,222)(H,177,234)(H,178,215)(H,179,225)(H,180,226)(H,181,223)(H,182,231)(H,183,232)(H,184,237)(H,185,233)(H,186,235)(H,187,238)(H,188,203)(H,189,227)(H,190,230)(H,191,228)(H,192,229)(H,204,205)(H,206,207)(H,208,209)(H,210,211)(H4,157,158,160)/t77-,78-,79-,80-,81-,82+,83+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,119-,120-,121-,122-,123-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.00600n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as increase in cAMP level by cAMP-response element/luciferase activation assay


J Med Chem 51: 2758-65 (2008)


Article DOI: 10.1021/jm701522b
BindingDB Entry DOI: 10.7270/Q2736QPR
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50261510
PNG
(CHEMBL499208 | c[Glu18-Lys22][Gly8]GLP-1(7-37)-NH2)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C156H236N42O46/c1-16-81(10)126(153(242)175-84(13)131(220)185-110(65-90-68-167-95-37-24-23-36-93(90)95)144(233)187-106(61-78(4)5)145(234)195-124(79(6)7)151(240)184-97(38-25-28-56-157)134(223)170-72-118(208)176-96(41-31-59-166-156(162)163)133(222)168-70-115(161)205)197-146(235)108(62-87-32-19-17-20-33-87)189-141(230)104(50-55-122(214)215)181-137(226)98(39-26-29-57-158)178-130(219)83(12)173-129(218)82(11)174-136(225)101(46-51-114(160)204)180-138(227)99-40-27-30-58-165-116(206)52-47-102(140(229)188-107(64-89-42-44-92(203)45-43-89)143(232)186-105(60-77(2)3)142(231)182-103(139(228)179-99)49-54-121(212)213)183-149(238)112(74-199)192-152(241)125(80(8)9)196-148(237)111(67-123(216)217)190-150(239)113(75-200)193-155(244)128(86(15)202)198-147(236)109(63-88-34-21-18-22-35-88)191-154(243)127(85(14)201)194-119(209)73-171-135(224)100(48-53-120(210)211)177-117(207)71-169-132(221)94(159)66-91-69-164-76-172-91/h17-24,32-37,42-45,68-69,76-86,94,96-113,124-128,167,199-203H,16,25-31,38-41,46-67,70-75,157-159H2,1-15H3,(H2,160,204)(H2,161,205)(H,164,172)(H,165,206)(H,168,222)(H,169,221)(H,170,223)(H,171,224)(H,173,218)(H,174,225)(H,175,242)(H,176,208)(H,177,207)(H,178,219)(H,179,228)(H,180,227)(H,181,226)(H,182,231)(H,183,238)(H,184,240)(H,185,220)(H,186,232)(H,187,233)(H,188,229)(H,189,230)(H,190,239)(H,191,243)(H,192,241)(H,193,244)(H,194,209)(H,195,234)(H,196,237)(H,197,235)(H,198,236)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H4,162,163,166)/t81-,82-,83-,84-,85+,86+,94-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,124-,125-,126-,127-,128-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.00600n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as increase in cAMP level by cAMP-response element/luciferase activation assay


J Med Chem 51: 2758-65 (2008)


Article DOI: 10.1021/jm701522b
BindingDB Entry DOI: 10.7270/Q2736QPR
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273757
PNG
((4S,7S,10S,13S,16S,22S)-4-((6S,12S,15S,18S,21S,24S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C149H223N41O46/c1-13-75(6)119(146(234)182-101(58-82-29-16-14-17-30-82)136(224)168-79(10)126(214)178-104(61-85-64-160-90-34-21-20-33-88(85)90)138(226)179-100(57-73(2)3)140(228)188-118(74(4)5)145(233)177-92(35-22-25-53-150)128(216)161-66-111(199)169-91(122(154)210)38-28-56-159-149(155)156)189-135(223)99(47-52-116(206)207)175-132(220)93(36-23-26-54-151)171-124(212)77(8)165-123(211)76(7)167-131(219)97(43-48-109(153)197)170-112(200)67-162-130(218)96(46-51-115(204)205)174-134(222)98-44-49-110(198)158-55-27-24-37-94(133(221)184-107(70-192)144(232)185-106(69-191)142(230)180-102(137(225)176-98)60-84-39-41-87(196)42-40-84)173-139(227)105(63-117(208)209)181-143(231)108(71-193)186-148(236)121(81(12)195)190-141(229)103(59-83-31-18-15-19-32-83)183-147(235)120(80(11)194)187-113(201)68-163-129(217)95(45-50-114(202)203)172-125(213)78(9)166-127(215)89(152)62-86-65-157-72-164-86/h14-21,29-34,39-42,64-65,72-81,89,91-108,118-121,160,191-196H,13,22-28,35-38,43-63,66-71,150-152H2,1-12H3,(H2,153,197)(H2,154,210)(H,157,164)(H,158,198)(H,161,216)(H,162,218)(H,163,217)(H,165,211)(H,166,215)(H,167,219)(H,168,224)(H,169,199)(H,170,200)(H,171,212)(H,172,213)(H,173,227)(H,174,222)(H,175,220)(H,176,225)(H,177,233)(H,178,214)(H,179,226)(H,180,230)(H,181,231)(H,182,234)(H,183,235)(H,184,221)(H,185,232)(H,186,236)(H,187,201)(H,188,228)(H,189,223)(H,190,229)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H4,155,156,159)/t75-,76-,77-,78-,79-,80+,81+,89-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,118-,119-,120-,121-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.00759n/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Activation of human GLP1R expressed in HEK293 cells assessed as effect on cAMP responsive element promoter driven luciferase expression


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50261519
PNG
(CHEMBL527077 | c[Glu22-Lys26][Gly8]GLP-1(7-37)-NH2)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc2cnc[nH]2)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O
Show InChI InChI=1S/C153H229N41O47/c1-16-78(10)123(150(239)171-81(13)128(217)180-106(61-87-64-163-92-35-24-23-34-90(87)92)140(229)182-102(57-75(4)5)141(230)191-121(76(6)7)148(237)179-94(36-25-27-53-154)131(220)166-68-115(205)172-93(38-29-55-162-153(158)159)130(219)164-66-112(157)202)193-142(231)104(58-84-30-19-17-20-31-84)183-137(226)100(47-52-119(211)212)177-135(224)98-44-49-113(203)161-54-28-26-37-95(134(223)176-97(43-48-111(156)201)133(222)170-79(11)126(215)169-80(12)127(216)174-98)175-136(225)99(46-51-118(209)210)178-138(227)101(56-74(2)3)181-139(228)103(60-86-39-41-89(200)42-40-86)184-145(234)108(70-195)187-147(236)110(72-197)188-149(238)122(77(8)9)192-144(233)107(63-120(213)214)185-146(235)109(71-196)189-152(241)125(83(15)199)194-143(232)105(59-85-32-21-18-22-33-85)186-151(240)124(82(14)198)190-116(206)69-167-132(221)96(45-50-117(207)208)173-114(204)67-165-129(218)91(155)62-88-65-160-73-168-88/h17-24,30-35,39-42,64-65,73-83,91,93-110,121-125,163,195-200H,16,25-29,36-38,43-63,66-72,154-155H2,1-15H3,(H2,156,201)(H2,157,202)(H,160,168)(H,161,203)(H,164,219)(H,165,218)(H,166,220)(H,167,221)(H,169,215)(H,170,222)(H,171,239)(H,172,205)(H,173,204)(H,174,216)(H,175,225)(H,176,223)(H,177,224)(H,178,227)(H,179,237)(H,180,217)(H,181,228)(H,182,229)(H,183,226)(H,184,234)(H,185,235)(H,186,240)(H,187,236)(H,188,238)(H,189,241)(H,190,206)(H,191,230)(H,192,233)(H,193,231)(H,194,232)(H,207,208)(H,209,210)(H,211,212)(H,213,214)(H4,158,159,162)/t78-,79-,80-,81-,82-,83-,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,121-,122-,123-,124-,125-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.00800n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as increase in cAMP level by cAMP-response element/luciferase activation assay


J Med Chem 51: 2758-65 (2008)


Article DOI: 10.1021/jm701522b
BindingDB Entry DOI: 10.7270/Q2736QPR
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50261516
PNG
(CHEMBL499133 | c[Glu23-Lys27][Gly8]GLP-1(7-37)-NH2)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O
Show InChI InChI=1S/C151H229N41O44/c1-16-79(10)122(148(234)170-82(13)127(213)178-106(61-88-64-161-93-37-24-23-36-91(88)93)138(224)180-102(57-76(4)5)139(225)189-120(77(6)7)146(232)177-95(38-25-28-52-152)130(216)164-68-114(202)171-94(41-31-55-160-151(156)157)129(215)162-66-111(155)199)191-140(226)104(58-85-32-19-17-20-33-85)181-135(221)97-40-27-30-54-159-112(200)49-46-100(133(219)169-80(11)125(211)168-81(12)126(212)174-96(134(220)175-97)39-26-29-53-153)173-115(203)69-165-132(218)99(48-51-118(207)208)176-136(222)101(56-75(2)3)179-137(223)103(60-87-42-44-90(198)45-43-87)182-143(229)108(71-193)185-145(231)110(73-195)186-147(233)121(78(8)9)190-142(228)107(63-119(209)210)183-144(230)109(72-194)187-150(236)124(84(15)197)192-141(227)105(59-86-34-21-18-22-35-86)184-149(235)123(83(14)196)188-116(204)70-166-131(217)98(47-50-117(205)206)172-113(201)67-163-128(214)92(154)62-89-65-158-74-167-89/h17-24,32-37,42-45,64-65,74-84,92,94-110,120-124,161,193-198H,16,25-31,38-41,46-63,66-73,152-154H2,1-15H3,(H2,155,199)(H,158,167)(H,159,200)(H,162,215)(H,163,214)(H,164,216)(H,165,218)(H,166,217)(H,168,211)(H,169,219)(H,170,234)(H,171,202)(H,172,201)(H,173,203)(H,174,212)(H,175,220)(H,176,222)(H,177,232)(H,178,213)(H,179,223)(H,180,224)(H,181,221)(H,182,229)(H,183,230)(H,184,235)(H,185,231)(H,186,233)(H,187,236)(H,188,204)(H,189,225)(H,190,228)(H,191,226)(H,192,227)(H,205,206)(H,207,208)(H,209,210)(H4,156,157,160)/t79-,80-,81-,82-,83+,84+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,120-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.00800n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as increase in cAMP level by cAMP-response element/luciferase activation assay


J Med Chem 51: 2758-65 (2008)


Article DOI: 10.1021/jm701522b
BindingDB Entry DOI: 10.7270/Q2736QPR
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50087746
PNG
(CHEMBL428139 | GLP-1(7-37) | Glucagon like peptide...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O
Show InChI InChI=1S/C151H228N40O47/c1-17-77(10)121(148(236)169-81(14)127(215)177-105(60-87-63-160-92-36-25-24-35-90(87)92)138(226)179-101(56-74(4)5)139(227)188-119(75(6)7)146(234)176-94(37-26-28-52-152)130(218)161-65-111(199)170-93(39-30-54-159-151(156)157)129(217)164-68-118(210)211)190-140(228)103(57-84-31-20-18-21-32-84)180-135(223)99(47-51-116(206)207)175-134(222)95(38-27-29-53-153)172-125(213)79(12)166-124(212)78(11)168-133(221)98(44-48-110(155)198)171-112(200)66-162-132(220)97(46-50-115(204)205)174-136(224)100(55-73(2)3)178-137(225)102(59-86-40-42-89(197)43-41-86)181-143(231)107(69-192)184-145(233)109(71-194)185-147(235)120(76(8)9)189-142(230)106(62-117(208)209)182-144(232)108(70-193)186-150(238)123(83(16)196)191-141(229)104(58-85-33-22-19-23-34-85)183-149(237)122(82(15)195)187-113(201)67-163-131(219)96(45-49-114(202)203)173-126(214)80(13)167-128(216)91(154)61-88-64-158-72-165-88/h18-25,31-36,40-43,63-64,72-83,91,93-109,119-123,160,192-197H,17,26-30,37-39,44-62,65-71,152-154H2,1-16H3,(H2,155,198)(H,158,165)(H,161,218)(H,162,220)(H,163,219)(H,164,217)(H,166,212)(H,167,216)(H,168,221)(H,169,236)(H,170,199)(H,171,200)(H,172,213)(H,173,214)(H,174,224)(H,175,222)(H,176,234)(H,177,215)(H,178,225)(H,179,226)(H,180,223)(H,181,231)(H,182,232)(H,183,237)(H,184,233)(H,185,235)(H,186,238)(H,187,201)(H,188,227)(H,189,230)(H,190,228)(H,191,229)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H,210,211)(H4,156,157,159)/t77-,78-,79-,80-,81-,82+,83+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,119-,120-,121-,122-,123-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/an/a 0.00800n/an/an/an/a



Novo Nordisk Als

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1 receptor expressed in BHK cells assessed as cAMP accumulation


Proc Natl Acad Sci USA 104: 937-42 (2007)


Article DOI: 10.1073/pnas.0605701104
BindingDB Entry DOI: 10.7270/Q21R6RD8
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50261515
PNG
(CHEMBL524907 | c[Glu22-Lys26][Gly8]GLP-1(7-37)-NH2)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc2cnc[nH]2)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O
Show InChI InChI=1S/C153H229N41O47/c1-16-78(10)123(150(239)171-81(13)128(217)180-106(61-87-64-163-92-35-24-23-34-90(87)92)140(229)182-102(57-75(4)5)141(230)191-121(76(6)7)148(237)179-94(36-25-27-53-154)131(220)166-68-115(205)172-93(38-29-55-162-153(158)159)130(219)164-66-112(157)202)193-142(231)104(58-84-30-19-17-20-31-84)183-137(226)100(47-52-119(211)212)177-134(223)95-37-26-28-54-161-113(203)49-44-98(135(224)175-97(43-48-111(156)201)133(222)170-79(11)126(215)169-80(12)127(216)174-95)176-136(225)99(46-51-118(209)210)178-138(227)101(56-74(2)3)181-139(228)103(60-86-39-41-89(200)42-40-86)184-145(234)108(70-195)187-147(236)110(72-197)188-149(238)122(77(8)9)192-144(233)107(63-120(213)214)185-146(235)109(71-196)189-152(241)125(83(15)199)194-143(232)105(59-85-32-21-18-22-33-85)186-151(240)124(82(14)198)190-116(206)69-167-132(221)96(45-50-117(207)208)173-114(204)67-165-129(218)91(155)62-88-65-160-73-168-88/h17-24,30-35,39-42,64-65,73-83,91,93-110,121-125,163,195-200H,16,25-29,36-38,43-63,66-72,154-155H2,1-15H3,(H2,156,201)(H2,157,202)(H,160,168)(H,161,203)(H,164,219)(H,165,218)(H,166,220)(H,167,221)(H,169,215)(H,170,222)(H,171,239)(H,172,205)(H,173,204)(H,174,216)(H,175,224)(H,176,225)(H,177,223)(H,178,227)(H,179,237)(H,180,217)(H,181,228)(H,182,229)(H,183,226)(H,184,234)(H,185,235)(H,186,240)(H,187,236)(H,188,238)(H,189,241)(H,190,206)(H,191,230)(H,192,233)(H,193,231)(H,194,232)(H,207,208)(H,209,210)(H,211,212)(H,213,214)(H4,158,159,162)/t78-,79-,80-,81-,82-,83-,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,121-,122-,123-,124-,125-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0100n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as increase in cAMP level by cAMP-response element/luciferase activation assay


J Med Chem 51: 2758-65 (2008)


Article DOI: 10.1021/jm701522b
BindingDB Entry DOI: 10.7270/Q2736QPR
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324722
PNG
((2S,4S,7S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S,...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H](CCNC(N)=N)C(N)=O
Show InChI InChI=1S/C151H226N38O49/c1-17-76(10)120(147(234)166-80(14)127(214)175-104(61-86-64-159-90-35-25-24-34-89(86)90)137(224)177-100(57-73(4)5)138(225)186-118(74(6)7)145(232)174-92(36-26-28-53-152)128(215)160-66-110(196)167-91(123(154)210)52-55-158-151(155)156)188-139(226)102(58-83-30-20-18-21-31-83)178-134(221)98(46-51-116(206)207)171-131(218)93(37-27-29-54-153)168-126(213)79(13)164-124(211)78(12)165-130(217)95(43-48-113(200)201)170-132(219)96(44-49-114(202)203)172-133(220)97(45-50-115(204)205)173-135(222)99(56-72(2)3)176-136(223)101(60-85-38-40-88(195)41-39-85)179-142(229)107(68-190)182-144(231)109(70-192)183-146(233)119(75(8)9)187-141(228)105(63-117(208)209)180-143(230)108(69-191)184-149(236)122(82(16)194)189-140(227)103(59-84-32-22-19-23-33-84)181-148(235)121(81(15)193)185-111(197)67-161-129(216)94(42-47-112(198)199)169-125(212)77(11)163-106(150(237)238)62-87-65-157-71-162-87/h18-25,30-35,38-41,64-65,71-82,91-109,118-122,159,163,190-195H,17,26-29,36-37,42-63,66-70,152-153H2,1-16H3,(H2,154,210)(H,157,162)(H,160,215)(H,161,216)(H,164,211)(H,165,217)(H,166,234)(H,167,196)(H,168,213)(H,169,212)(H,170,219)(H,171,218)(H,172,220)(H,173,222)(H,174,232)(H,175,214)(H,176,223)(H,177,224)(H,178,221)(H,179,229)(H,180,230)(H,181,235)(H,182,231)(H,183,233)(H,184,236)(H,185,197)(H,186,225)(H,187,228)(H,188,226)(H,189,227)(H,198,199)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H,237,238)(H4,155,156,158)/t76-,77-,78-,79-,80-,81+,82-,91+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,118-,119-,120-,121-,122-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0110n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273758
PNG
((4S,7S,10S,13S,16S,22S,25S,28S,31S,34S,37S,40S,43S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C151H228N42O47/c1-14-76(6)121(148(238)185-103(59-84-30-17-15-18-31-84)138(228)171-80(10)128(218)181-106(62-87-65-163-92-35-22-21-34-90(87)92)140(230)182-102(58-74(2)3)142(232)191-120(75(4)5)147(237)180-94(36-23-26-54-152)130(220)164-67-113(203)172-93(124(157)214)39-29-57-162-151(158)159)192-137(227)101(48-53-118(210)211)178-134(224)95(37-24-27-55-153)174-126(216)78(8)168-125(215)77(7)170-133(223)99(44-49-111(155)201)173-114(204)68-165-132(222)98(47-52-117(208)209)177-136(226)100(45-50-112(156)202)179-139(229)104(61-86-40-42-89(200)43-41-86)183-144(234)108(70-194)188-146(236)109(71-195)187-135(225)96(38-25-28-56-161-83(13)199)176-141(231)107(64-119(212)213)184-145(235)110(72-196)189-150(240)123(82(12)198)193-143(233)105(60-85-32-19-16-20-33-85)186-149(239)122(81(11)197)190-115(205)69-166-131(221)97(46-51-116(206)207)175-127(217)79(9)169-129(219)91(154)63-88-66-160-73-167-88/h15-22,30-35,40-43,65-66,73-82,91,93-110,120-123,163,194-198,200H,14,23-29,36-39,44-64,67-72,152-154H2,1-13H3,(H2,155,201)(H2,156,202)(H2,157,214)(H,160,167)(H,161,199)(H,164,220)(H,165,222)(H,166,221)(H,168,215)(H,169,219)(H,170,223)(H,171,228)(H,172,203)(H,173,204)(H,174,216)(H,175,217)(H,176,231)(H,177,226)(H,178,224)(H,179,229)(H,180,237)(H,181,218)(H,182,230)(H,183,234)(H,184,235)(H,185,238)(H,186,239)(H,187,225)(H,188,236)(H,189,240)(H,190,205)(H,191,232)(H,192,227)(H,193,233)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,158,159,162)/t76-,77-,78-,79-,80-,81+,82+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,120-,121-,122-,123-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0120n/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Activation of human GLP1R expressed in HEK293 cells assessed as effect on cAMP responsive element promoter driven luciferase expression


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324729
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,38S,44S)...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)CN[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H220N36O48S/c1-15-76(6)122(149(231)166-80(10)129(211)174-107(62-88-68-161-93-33-23-22-32-92(88)93)141(223)176-101(56-74(2)3)137(219)173-100(52-55-238-14)136(218)180-108(64-116(157)199)146(228)189-125(83(13)194)153(236)237)187-144(226)105(58-84-28-18-16-19-29-84)178-135(217)99(47-51-119(202)203)171-132(214)94-35-25-27-54-159-117(200)50-46-98(134(216)170-97(45-49-115(156)198)131(213)165-78(8)127(209)164-79(9)128(210)168-94)172-142(224)109(65-120(204)205)181-138(220)102(57-75(4)5)175-139(221)103(60-86-36-40-90(195)41-37-86)177-133(215)95(34-24-26-53-154)169-147(229)112(71-190)184-140(222)104(61-87-38-42-91(196)43-39-87)179-143(225)110(66-121(206)207)182-148(230)113(72-191)185-151(233)124(82(12)193)188-145(227)106(59-85-30-20-17-21-31-85)183-150(232)123(81(11)192)186-118(201)70-162-130(212)96(44-48-114(155)197)167-126(208)77(7)67-160-111(152(234)235)63-89-69-158-73-163-89/h16-23,28-33,36-43,68-69,73-83,94-113,122-125,160-161,190-196H,15,24-27,34-35,44-67,70-72,154H2,1-14H3,(H2,155,197)(H2,156,198)(H2,157,199)(H,158,163)(H,159,200)(H,162,212)(H,164,209)(H,165,213)(H,166,231)(H,167,208)(H,168,210)(H,169,229)(H,170,216)(H,171,214)(H,172,224)(H,173,219)(H,174,211)(H,175,221)(H,176,223)(H,177,215)(H,178,217)(H,179,225)(H,180,218)(H,181,220)(H,182,230)(H,183,232)(H,184,222)(H,185,233)(H,186,201)(H,187,226)(H,188,227)(H,189,228)(H,202,203)(H,204,205)(H,206,207)(H,234,235)(H,236,237)/t76-,77?,78-,79-,80-,81+,82+,83+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0130n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324728
PNG
((2S,8S,14S,17S,20S,23S,26S,29S,32S,35S,38S,41S,44S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)CN[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H222N36O49S/c1-15-76(6)122(149(232)166-80(10)129(212)174-107(62-88-68-161-93-33-23-22-32-92(88)93)141(224)176-101(56-74(2)3)137(220)173-100(52-55-239-14)136(219)180-108(64-116(158)199)146(229)189-125(83(13)194)153(237)238)187-144(227)105(58-84-28-18-16-19-29-84)178-135(218)99(47-51-119(203)204)171-132(215)94(34-24-26-53-154)168-128(211)79(9)164-127(210)78(8)165-131(214)97(45-49-115(157)198)170-134(217)98(46-50-118(201)202)172-142(225)109(65-120(205)206)181-138(221)102(57-75(4)5)175-139(222)103(60-86-36-40-90(195)41-37-86)177-133(216)95(35-25-27-54-155)169-147(230)112(71-190)184-140(223)104(61-87-38-42-91(196)43-39-87)179-143(226)110(66-121(207)208)182-148(231)113(72-191)185-151(234)124(82(12)193)188-145(228)106(59-85-30-20-17-21-31-85)183-150(233)123(81(11)192)186-117(200)70-162-130(213)96(44-48-114(156)197)167-126(209)77(7)67-160-111(152(235)236)63-89-69-159-73-163-89/h16-23,28-33,36-43,68-69,73-83,94-113,122-125,160-161,190-196H,15,24-27,34-35,44-67,70-72,154-155H2,1-14H3,(H2,156,197)(H2,157,198)(H2,158,199)(H,159,163)(H,162,213)(H,164,210)(H,165,214)(H,166,232)(H,167,209)(H,168,211)(H,169,230)(H,170,217)(H,171,215)(H,172,225)(H,173,220)(H,174,212)(H,175,222)(H,176,224)(H,177,216)(H,178,218)(H,179,226)(H,180,219)(H,181,221)(H,182,231)(H,183,233)(H,184,223)(H,185,234)(H,186,200)(H,187,227)(H,188,228)(H,189,229)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)(H,237,238)/t76-,77?,78-,79-,80-,81+,82+,83+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0140n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50261507
PNG
(CHEMBL526685 | [Gly8]GLP-1(7-37)-NH2)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O
Show InChI InChI=1S/C150H226N40O47/c1-16-77(10)121(147(235)168-80(13)126(214)176-104(59-86-62-159-91-35-24-23-34-89(86)91)137(225)178-100(55-74(4)5)138(226)187-119(75(6)7)145(233)175-93(36-25-27-51-151)129(217)161-65-111(199)169-92(38-29-53-158-150(155)156)128(216)164-68-118(210)211)189-139(227)102(56-83-30-19-17-20-31-83)179-134(222)98(46-50-116(206)207)174-133(221)94(37-26-28-52-152)172-125(213)79(12)166-124(212)78(11)167-132(220)97(43-47-109(154)197)171-112(200)66-162-131(219)96(45-49-115(204)205)173-135(223)99(54-73(2)3)177-136(224)101(58-85-39-41-88(196)42-40-85)180-142(230)106(69-191)183-144(232)108(71-193)184-146(234)120(76(8)9)188-141(229)105(61-117(208)209)181-143(231)107(70-192)185-149(237)123(82(15)195)190-140(228)103(57-84-32-21-18-22-33-84)182-148(236)122(81(14)194)186-113(201)67-163-130(218)95(44-48-114(202)203)170-110(198)64-160-127(215)90(153)60-87-63-157-72-165-87/h17-24,30-35,39-42,62-63,72-82,90,92-108,119-123,159,191-196H,16,25-29,36-38,43-61,64-71,151-153H2,1-15H3,(H2,154,197)(H,157,165)(H,160,215)(H,161,217)(H,162,219)(H,163,218)(H,164,216)(H,166,212)(H,167,220)(H,168,235)(H,169,199)(H,170,198)(H,171,200)(H,172,213)(H,173,223)(H,174,221)(H,175,233)(H,176,214)(H,177,224)(H,178,225)(H,179,222)(H,180,230)(H,181,231)(H,182,236)(H,183,232)(H,184,234)(H,185,237)(H,186,201)(H,187,226)(H,188,229)(H,189,227)(H,190,228)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H,210,211)(H4,155,156,158)/t77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,119-,120-,121-,122-,123-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0140n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as increase in cAMP level by cAMP-response element/luciferase activation assay


J Med Chem 51: 2758-65 (2008)


Article DOI: 10.1021/jm701522b
BindingDB Entry DOI: 10.7270/Q2736QPR
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324712
PNG
(CHEMBL1222086 | HSQGTFTSDYSKYLDEQAAKEFIAWLVKG)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(O)=O
Show InChI InChI=1S/C152H222N36O48/c1-14-78(8)123(149(232)165-81(11)128(211)174-107(63-88-67-159-93-34-22-21-33-92(88)93)139(222)176-102(58-76(4)5)142(225)186-122(77(6)7)148(231)173-94(35-23-26-54-153)129(212)161-70-121(207)208)187-143(226)105(59-84-29-17-15-18-30-84)178-135(218)100(49-53-118(201)202)171-132(215)95(36-24-27-55-154)167-127(210)80(10)163-126(209)79(9)164-131(214)98(47-51-115(157)197)170-134(217)99(48-52-117(199)200)172-140(223)108(65-119(203)204)180-136(219)101(57-75(2)3)175-137(220)103(61-86-38-42-90(194)43-39-86)177-133(216)96(37-25-28-56-155)168-146(229)112(72-190)183-138(221)104(62-87-40-44-91(195)45-41-87)179-141(224)109(66-120(205)206)181-147(230)113(73-191)184-151(234)125(83(13)193)188-144(227)106(60-85-31-19-16-20-32-85)182-150(233)124(82(12)192)185-116(198)69-160-130(213)97(46-50-114(156)196)169-145(228)111(71-189)166-110(152(235)236)64-89-68-158-74-162-89/h15-22,29-34,38-45,67-68,74-83,94-113,122-125,159,166,189-195H,14,23-28,35-37,46-66,69-73,153-155H2,1-13H3,(H2,156,196)(H2,157,197)(H,158,162)(H,160,213)(H,161,212)(H,163,209)(H,164,214)(H,165,232)(H,167,210)(H,168,229)(H,169,228)(H,170,217)(H,171,215)(H,172,223)(H,173,231)(H,174,211)(H,175,220)(H,176,222)(H,177,216)(H,178,218)(H,179,224)(H,180,219)(H,181,230)(H,182,233)(H,183,221)(H,184,234)(H,185,198)(H,186,225)(H,187,226)(H,188,227)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)/t78-,79-,80-,81-,82+,83+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0150n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50261520
PNG
(CHEMBL526730 | c[Glu22-Orn26][Gly8]GLP-1(7-37)-NH2)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc2c[nH]cn2)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C152H227N41O47/c1-16-77(10)122(149(238)170-80(13)127(216)179-105(60-86-63-162-91-34-24-23-33-89(86)91)139(228)181-101(56-74(4)5)140(229)190-120(75(6)7)147(236)178-93(35-25-26-52-153)130(219)165-67-114(204)171-92(36-28-54-161-152(157)158)129(218)163-65-111(156)201)192-141(230)103(57-83-29-19-17-20-30-83)182-136(225)99(46-51-118(210)211)176-133(222)94-37-27-53-160-112(202)48-43-97(134(223)174-96(42-47-110(155)200)132(221)169-78(11)125(214)168-79(12)126(215)173-94)175-135(224)98(45-50-117(208)209)177-137(226)100(55-73(2)3)180-138(227)102(59-85-38-40-88(199)41-39-85)183-144(233)107(69-194)186-146(235)109(71-196)187-148(237)121(76(8)9)191-143(232)106(62-119(212)213)184-145(234)108(70-195)188-151(240)124(82(15)198)193-142(231)104(58-84-31-21-18-22-32-84)185-150(239)123(81(14)197)189-115(205)68-166-131(220)95(44-49-116(206)207)172-113(203)66-164-128(217)90(154)61-87-64-159-72-167-87/h17-24,29-34,38-41,63-64,72-82,90,92-109,120-124,162,194-199H,16,25-28,35-37,42-62,65-71,153-154H2,1-15H3,(H2,155,200)(H2,156,201)(H,159,167)(H,160,202)(H,163,218)(H,164,217)(H,165,219)(H,166,220)(H,168,214)(H,169,221)(H,170,238)(H,171,204)(H,172,203)(H,173,215)(H,174,223)(H,175,224)(H,176,222)(H,177,226)(H,178,236)(H,179,216)(H,180,227)(H,181,228)(H,182,225)(H,183,233)(H,184,234)(H,185,239)(H,186,235)(H,187,237)(H,188,240)(H,189,205)(H,190,229)(H,191,232)(H,192,230)(H,193,231)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,157,158,161)/t77-,78-,79-,80-,81-,82-,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,120-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0190n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as increase in cAMP level by cAMP-response element/luciferase activation assay


J Med Chem 51: 2758-65 (2008)


Article DOI: 10.1021/jm701522b
BindingDB Entry DOI: 10.7270/Q2736QPR
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50261518
PNG
(CHEMBL500447 | c[Glu26-Lys30][Gly8]GLP-1(7-37)-NH2)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C
Show InChI InChI=1S/C152H227N41O47/c1-15-78(10)123-149(238)178-94(134(223)183-105(60-86-63-162-91-34-23-22-33-89(86)91)139(228)180-101(56-75(4)5)140(229)190-121(76(6)7)147(236)177-93(35-24-26-52-153)130(219)165-67-114(204)171-92(37-28-54-161-152(157)158)129(218)163-65-111(156)201)36-25-27-53-160-112(202)48-43-98(135(224)176-99(46-51-119(211)212)136(225)181-103(141(230)192-123)57-83-29-18-16-19-30-83)174-127(216)80(12)169-126(215)79(11)170-133(222)97(42-47-110(155)200)173-115(205)68-166-132(221)96(45-50-118(209)210)175-137(226)100(55-74(2)3)179-138(227)102(59-85-38-40-88(199)41-39-85)182-144(233)107(70-194)186-146(235)109(72-196)187-148(237)122(77(8)9)191-143(232)106(62-120(213)214)184-145(234)108(71-195)188-151(240)125(82(14)198)193-142(231)104(58-84-31-20-17-21-32-84)185-150(239)124(81(13)197)189-116(206)69-167-131(220)95(44-49-117(207)208)172-113(203)66-164-128(217)90(154)61-87-64-159-73-168-87/h16-23,29-34,38-41,63-64,73-82,90,92-109,121-125,162,194-199H,15,24-28,35-37,42-62,65-72,153-154H2,1-14H3,(H2,155,200)(H2,156,201)(H,159,168)(H,160,202)(H,163,218)(H,164,217)(H,165,219)(H,166,221)(H,167,220)(H,169,215)(H,170,222)(H,171,204)(H,172,203)(H,173,205)(H,174,216)(H,175,226)(H,176,224)(H,177,236)(H,178,238)(H,179,227)(H,180,228)(H,181,225)(H,182,233)(H,183,223)(H,184,234)(H,185,239)(H,186,235)(H,187,237)(H,188,240)(H,189,206)(H,190,229)(H,191,232)(H,192,230)(H,193,231)(H,207,208)(H,209,210)(H,211,212)(H,213,214)(H4,157,158,161)/t78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,121-,122-,123-,124-,125-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0240n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as increase in cAMP level by cAMP-response element/luciferase activation assay


J Med Chem 51: 2758-65 (2008)


Article DOI: 10.1021/jm701522b
BindingDB Entry DOI: 10.7270/Q2736QPR
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324713
PNG
(CHEMBL1222087 | HSQGTFTSDYSKYLDEQAAKEFIAWLMNT)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C152H220N36O50S/c1-14-75(6)121(148(232)164-78(9)127(211)173-105(61-86-66-159-91-32-22-21-31-90(86)91)139(223)175-99(55-73(2)3)135(219)172-98(51-54-239-13)134(218)179-106(63-115(157)199)144(228)188-124(81(12)194)152(237)238)186-142(226)103(57-82-27-17-15-18-28-82)177-133(217)97(46-50-118(203)204)170-130(214)92(33-23-25-52-153)166-126(210)77(8)162-125(209)76(7)163-129(213)95(44-48-114(156)198)169-132(216)96(45-49-117(201)202)171-140(224)107(64-119(205)206)180-136(220)100(56-74(4)5)174-137(221)101(59-84-35-39-88(195)40-36-84)176-131(215)93(34-24-26-53-154)167-146(230)111(70-190)183-138(222)102(60-85-37-41-89(196)42-38-85)178-141(225)108(65-120(207)208)181-147(231)112(71-191)184-150(234)123(80(11)193)187-143(227)104(58-83-29-19-16-20-30-83)182-149(233)122(79(10)192)185-116(200)68-160-128(212)94(43-47-113(155)197)168-145(229)110(69-189)165-109(151(235)236)62-87-67-158-72-161-87/h15-22,27-32,35-42,66-67,72-81,92-112,121-124,159,165,189-196H,14,23-26,33-34,43-65,68-71,153-154H2,1-13H3,(H2,155,197)(H2,156,198)(H2,157,199)(H,158,161)(H,160,212)(H,162,209)(H,163,213)(H,164,232)(H,166,210)(H,167,230)(H,168,229)(H,169,216)(H,170,214)(H,171,224)(H,172,219)(H,173,211)(H,174,221)(H,175,223)(H,176,215)(H,177,217)(H,178,225)(H,179,218)(H,180,220)(H,181,231)(H,182,233)(H,183,222)(H,184,234)(H,185,200)(H,186,226)(H,187,227)(H,188,228)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)(H,237,238)/t75-,76-,77-,78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0260n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50261509
PNG
(CHEMBL499370 | [Gly8, aib22]GLP-1(7-37)-NH2)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O
Show InChI InChI=1S/C152H231N41O46/c1-18-78(10)121(147(236)170-81(13)126(215)177-105(61-87-64-162-92-37-26-25-36-90(87)92)136(225)179-101(57-75(4)5)137(226)189-119(76(6)7)145(234)176-94(38-27-29-53-153)129(218)165-68-113(203)171-93(40-31-55-161-151(158)159)128(217)163-66-111(157)201)191-138(227)103(58-84-32-21-19-22-33-84)180-133(222)97(47-51-116(207)208)174-132(221)95(39-28-30-54-154)173-125(214)80(12)168-124(213)79(11)169-131(220)98(45-49-110(156)200)187-150(239)152(16,17)193-144(233)99(48-52-117(209)210)175-134(223)100(56-74(2)3)178-135(224)102(60-86-41-43-89(199)44-42-86)181-141(230)107(70-194)184-143(232)109(72-196)185-146(235)120(77(8)9)190-140(229)106(63-118(211)212)182-142(231)108(71-195)186-149(238)123(83(15)198)192-139(228)104(59-85-34-23-20-24-35-85)183-148(237)122(82(14)197)188-114(204)69-166-130(219)96(46-50-115(205)206)172-112(202)67-164-127(216)91(155)62-88-65-160-73-167-88/h19-26,32-37,41-44,64-65,73-83,91,93-109,119-123,162,194-199H,18,27-31,38-40,45-63,66-72,153-155H2,1-17H3,(H2,156,200)(H2,157,201)(H,160,167)(H,163,217)(H,164,216)(H,165,218)(H,166,219)(H,168,213)(H,169,220)(H,170,236)(H,171,203)(H,172,202)(H,173,214)(H,174,221)(H,175,223)(H,176,234)(H,177,215)(H,178,224)(H,179,225)(H,180,222)(H,181,230)(H,182,231)(H,183,237)(H,184,232)(H,185,235)(H,186,238)(H,187,239)(H,188,204)(H,189,226)(H,190,229)(H,191,227)(H,192,228)(H,193,233)(H,205,206)(H,207,208)(H,209,210)(H,211,212)(H4,158,159,161)/t78-,79-,80-,81-,82+,83+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,119-,120-,121-,122-,123-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0270n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as increase in cAMP level by cAMP-response element/luciferase activation assay


J Med Chem 51: 2758-65 (2008)


Article DOI: 10.1021/jm701522b
BindingDB Entry DOI: 10.7270/Q2736QPR
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324715
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C153H224N40O49S/c1-73(2)54-98(135(224)175-97(49-53-243-12)134(223)183-105(62-115(158)204)145(234)192-122(78(9)197)125(159)214)178-139(228)104(60-85-66-164-90-31-20-19-30-89(85)90)182-133(222)95(44-47-114(157)203)176-149(238)121(75(5)6)191-143(232)102(56-81-26-15-13-16-27-81)181-141(230)107(64-119(210)211)184-130(219)91(32-21-23-50-154)170-127(216)77(8)167-126(215)76(7)168-129(218)93(34-25-52-163-153(160)161)171-132(221)96(45-48-117(206)207)174-140(229)106(63-118(208)209)185-136(225)99(55-74(3)4)177-137(226)100(58-83-35-39-87(200)40-36-83)179-131(220)92(33-22-24-51-155)172-147(236)111(70-195)188-138(227)101(59-84-37-41-88(201)42-38-84)180-142(231)108(65-120(212)213)186-148(237)112(71-196)189-151(240)124(80(11)199)193-144(233)103(57-82-28-17-14-18-29-82)187-150(239)123(79(10)198)190-116(205)68-165-128(217)94(43-46-113(156)202)173-146(235)110(69-194)169-109(152(241)242)61-86-67-162-72-166-86/h13-20,26-31,35-42,66-67,72-80,91-112,121-124,164,169,194-201H,21-25,32-34,43-65,68-71,154-155H2,1-12H3,(H2,156,202)(H2,157,203)(H2,158,204)(H2,159,214)(H,162,166)(H,165,217)(H,167,215)(H,168,218)(H,170,216)(H,171,221)(H,172,236)(H,173,235)(H,174,229)(H,175,224)(H,176,238)(H,177,226)(H,178,228)(H,179,220)(H,180,231)(H,181,230)(H,182,222)(H,183,223)(H,184,219)(H,185,225)(H,186,237)(H,187,239)(H,188,227)(H,189,240)(H,190,205)(H,191,232)(H,192,234)(H,193,233)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H,241,242)(H4,160,161,163)/t76-,77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0280n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324721
PNG
((2S,4S,7S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S,...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C152H219N35O51S/c1-14-75(6)121(148(232)163-78(9)127(211)172-105(61-86-66-158-91-32-22-21-31-90(86)91)139(223)174-99(55-73(2)3)135(219)171-98(51-54-239-13)134(218)178-106(63-114(156)197)144(228)187-124(81(12)193)152(237)238)185-142(226)103(57-82-27-17-15-18-28-82)176-133(217)97(46-50-118(203)204)169-130(214)92(33-23-25-52-153)165-126(210)77(8)161-125(209)76(7)162-129(213)95(43-47-113(155)196)168-132(216)96(45-49-117(201)202)170-140(224)107(64-119(205)206)179-136(220)100(56-74(4)5)173-137(221)101(59-84-35-39-88(194)40-36-84)175-131(215)93(34-24-26-53-154)166-146(230)111(70-189)182-138(222)102(60-85-37-41-89(195)42-38-85)177-141(225)108(65-120(207)208)180-147(231)112(71-190)183-150(234)123(80(11)192)186-143(227)104(58-83-29-19-16-20-30-83)181-149(233)122(79(10)191)184-115(198)68-159-128(212)94(44-48-116(199)200)167-145(229)110(69-188)164-109(151(235)236)62-87-67-157-72-160-87/h15-22,27-32,35-42,66-67,72-81,92-112,121-124,158,164,188-195H,14,23-26,33-34,43-65,68-71,153-154H2,1-13H3,(H2,155,196)(H2,156,197)(H,157,160)(H,159,212)(H,161,209)(H,162,213)(H,163,232)(H,165,210)(H,166,230)(H,167,229)(H,168,216)(H,169,214)(H,170,224)(H,171,219)(H,172,211)(H,173,221)(H,174,223)(H,175,215)(H,176,217)(H,177,225)(H,178,218)(H,179,220)(H,180,231)(H,181,233)(H,182,222)(H,183,234)(H,184,198)(H,185,226)(H,186,227)(H,187,228)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)(H,237,238)/t75-,76-,77-,78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0280n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324731
PNG
(CHEMBL1222074 | HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C149H225N39O46/c1-17-76(10)119(145(230)166-80(14)126(211)174-103(60-86-63-158-90-36-25-24-35-89(86)90)135(220)176-99(56-73(4)5)136(221)185-117(74(6)7)143(228)173-92(37-26-28-52-150)127(212)159-65-110(196)167-91(122(153)207)39-30-54-157-149(154)155)187-137(222)101(57-83-31-20-18-21-32-83)177-132(217)97(47-51-115(203)204)172-131(216)93(38-27-29-53-151)169-125(210)79(13)164-123(208)78(12)165-130(215)96(44-48-109(152)195)168-111(197)66-160-129(214)95(46-50-114(201)202)171-133(218)98(55-72(2)3)175-134(219)100(59-85-40-42-88(194)43-41-85)178-140(225)106(68-189)181-142(227)108(70-191)182-144(229)118(75(8)9)186-139(224)104(62-116(205)206)179-141(226)107(69-190)183-147(232)121(82(16)193)188-138(223)102(58-84-33-22-19-23-34-84)180-146(231)120(81(15)192)184-112(198)67-161-128(213)94(45-49-113(199)200)170-124(209)77(11)163-105(148(233)234)61-87-64-156-71-162-87/h18-25,31-36,40-43,63-64,71-82,91-108,117-121,158,163,189-194H,17,26-30,37-39,44-62,65-70,150-151H2,1-16H3,(H2,152,195)(H2,153,207)(H,156,162)(H,159,212)(H,160,214)(H,161,213)(H,164,208)(H,165,215)(H,166,230)(H,167,196)(H,168,197)(H,169,210)(H,170,209)(H,171,218)(H,172,216)(H,173,228)(H,174,211)(H,175,219)(H,176,220)(H,177,217)(H,178,225)(H,179,226)(H,180,231)(H,181,227)(H,182,229)(H,183,232)(H,184,198)(H,185,221)(H,186,224)(H,187,222)(H,188,223)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,233,234)(H4,154,155,157)/t76-,77-,78-,79-,80-,81+,82-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0330n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50301949
PNG
((4S,7S,10S,13S,16S,22S,25S,28S,31S,34S,37S,40S,43S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C144H224N40O45/c1-18-72(10)113(140(226)162-76(14)121(207)170-98(56-82-59-154-86-37-26-25-36-84(82)86)130(216)171-95(53-69(4)5)131(217)180-111(70(6)7)138(224)169-88(38-27-29-49-145)123(209)155-61-104(192)163-87(117(149)203)40-31-51-153-144(150)151)182-132(218)96(54-80-32-21-19-22-33-80)172-128(214)93(44-48-109(199)200)168-127(213)89(39-28-30-50-146)165-119(205)74(12)159-118(204)73(11)161-126(212)92(41-45-103(148)191)164-105(193)62-156-125(211)91(43-47-108(197)198)167-129(215)94(52-68(2)3)174-142(228)115(78(16)189)184-137(223)102(66-187)176-136(222)101(65-186)177-139(225)112(71(8)9)181-134(220)99(58-110(201)202)173-135(221)100(64-185)178-143(229)116(79(17)190)183-133(219)97(55-81-34-23-20-24-35-81)175-141(227)114(77(15)188)179-106(194)63-157-124(210)90(42-46-107(195)196)166-120(206)75(13)160-122(208)85(147)57-83-60-152-67-158-83/h19-26,32-37,59-60,67-79,85,87-102,111-116,154,185-190H,18,27-31,38-58,61-66,145-147H2,1-17H3,(H2,148,191)(H2,149,203)(H,152,158)(H,155,209)(H,156,211)(H,157,210)(H,159,204)(H,160,208)(H,161,212)(H,162,226)(H,163,192)(H,164,193)(H,165,205)(H,166,206)(H,167,215)(H,168,213)(H,169,224)(H,170,207)(H,171,216)(H,172,214)(H,173,221)(H,174,228)(H,175,227)(H,176,222)(H,177,225)(H,178,229)(H,179,194)(H,180,217)(H,181,220)(H,182,218)(H,183,219)(H,184,223)(H,195,196)(H,197,198)(H,199,200)(H,201,202)(H4,150,151,153)/t72-,73-,74-,75-,76-,77+,78+,79+,85-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,111-,112-,113-,114-,115-,116-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0340n/an/an/an/a



Bristol-Myers Squibb Company Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as stimulation of intracellular [3H]cAMP accumulation after 30 mins by scintillation ...


J Med Chem 52: 7788-99 (2009)


Article DOI: 10.1021/jm900752a
BindingDB Entry DOI: 10.7270/Q2VH5PRK
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50086602
PNG
(CHEMBL3426300)
Show SMILES CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2ccccc2F)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc2ccc(O)c(I)c2)C(N)=O)cc1
Show InChI InChI=1S/C69H88FIN14O20/c1-8-38-26-42(105-7)18-19-43(38)39-16-13-36(14-17-39)24-49(61(98)77-48(58(73)95)25-37-15-21-52(89)45(71)23-37)78-62(99)50(28-55(93)94)79-63(100)51(32-86)80-64(101)56(34(2)87)83-67(104)69(6,29-40-11-9-10-12-44(40)70)85-65(102)57(35(3)88)82-53(90)31-75-60(97)47(20-22-54(91)92)81-66(103)68(4,5)84-59(96)46(72)27-41-30-74-33-76-41/h9-19,21,23,26,30,33-35,46-51,56-57,86-89H,8,20,22,24-25,27-29,31-32,72H2,1-7H3,(H2,73,95)(H,74,76)(H,75,97)(H,77,98)(H,78,99)(H,79,100)(H,80,101)(H,81,103)(H,82,90)(H,83,104)(H,84,96)(H,85,102)(H,91,92)(H,93,94)/t34-,35-,46+,47+,48+,49+,50+,51+,56+,57+,69+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0450n/an/an/an/a



University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP-1R expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins


J Med Chem 58: 4080-5 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00166
BindingDB Entry DOI: 10.7270/Q2DB83KP
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324725
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,38S,41S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C156H228N42O49S/c1-75(2)56-100(136(227)180-99(50-55-248-11)135(226)188-107(64-117(160)209)146(237)198-126(81(10)204)154(246)247)183-140(231)106(62-86-68-169-91-31-19-18-30-90(86)91)187-134(225)97(45-48-116(159)208)181-150(241)123(77(5)6)196-144(235)104(58-82-26-14-12-15-27-82)186-142(233)109(66-121(214)215)189-131(222)92-33-21-23-52-166-118(210)49-46-98(133(224)176-95(35-25-54-168-156(163)164)130(221)175-94(34-24-53-167-155(161)162)129(220)172-78(7)127(218)174-92)179-141(232)108(65-120(212)213)190-137(228)101(57-76(3)4)182-138(229)102(60-84-36-40-88(205)41-37-84)184-132(223)93(32-20-22-51-157)177-148(239)113(72-200)193-139(230)103(61-85-38-42-89(206)43-39-85)185-143(234)110(67-122(216)217)191-149(240)114(73-201)194-152(243)125(80(9)203)197-145(236)105(59-83-28-16-13-17-29-83)192-151(242)124(79(8)202)195-119(211)70-170-128(219)96(44-47-115(158)207)178-147(238)112(71-199)173-111(153(244)245)63-87-69-165-74-171-87/h12-19,26-31,36-43,68-69,74-81,92-114,123-126,169,173,199-206H,20-25,32-35,44-67,70-73,157H2,1-11H3,(H2,158,207)(H2,159,208)(H2,160,209)(H,165,171)(H,166,210)(H,170,219)(H,172,220)(H,174,218)(H,175,221)(H,176,224)(H,177,239)(H,178,238)(H,179,232)(H,180,227)(H,181,241)(H,182,229)(H,183,231)(H,184,223)(H,185,234)(H,186,233)(H,187,225)(H,188,226)(H,189,222)(H,190,228)(H,191,240)(H,192,242)(H,193,230)(H,194,243)(H,195,211)(H,196,235)(H,197,236)(H,198,237)(H,212,213)(H,214,215)(H,216,217)(H,244,245)(H,246,247)(H4,161,162,167)(H4,163,164,168)/t78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-,126-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0490n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324724
PNG
((2S,5S,8S,11S,14S,20S,23S,25S)-2-((S)-1-((S)-1-((2...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C155H224N42O50S/c1-73(2)54-98(135(227)179-97(49-53-248-11)134(226)187-105(62-116(159)209)145(237)197-125(79(10)203)153(246)247)182-139(231)104(60-84-66-168-89-29-19-18-28-88(84)89)186-133(225)95(43-47-115(158)208)180-149(241)122(75(5)6)195-143(235)102(56-80-24-14-12-15-25-80)185-141(233)107(64-120(214)215)188-132(224)94(42-46-114(157)207)173-126(218)76(7)171-128(220)91(31-22-51-166-154(160)161)174-129(221)92(32-23-52-167-155(162)163)175-131(223)96-44-48-117(210)165-50-21-20-30-90(130(222)183-100(58-82-33-37-86(204)38-34-82)137(229)181-99(55-74(3)4)136(228)189-106(63-119(212)213)140(232)178-96)176-147(239)111(70-199)192-138(230)101(59-83-35-39-87(205)40-36-83)184-142(234)108(65-121(216)217)190-148(240)112(71-200)193-151(243)124(78(9)202)196-144(236)103(57-81-26-16-13-17-27-81)191-150(242)123(77(8)201)194-118(211)68-169-127(219)93(41-45-113(156)206)177-146(238)110(69-198)172-109(152(244)245)61-85-67-164-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,168,172,198-205H,20-23,30-32,41-65,68-71H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,170)(H,165,210)(H,169,219)(H,171,220)(H,173,218)(H,174,221)(H,175,223)(H,176,239)(H,177,238)(H,178,232)(H,179,227)(H,180,241)(H,181,229)(H,182,231)(H,183,222)(H,184,234)(H,185,233)(H,186,225)(H,187,226)(H,188,224)(H,189,228)(H,190,240)(H,191,242)(H,192,230)(H,193,243)(H,194,211)(H,195,235)(H,196,236)(H,197,237)(H,212,213)(H,214,215)(H,216,217)(H,244,245)(H,246,247)(H4,160,161,166)(H4,162,163,167)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0510n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324717
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C161H240N44O51S/c1-13-79(6)126(155(251)187-100(47-50-119(165)216)139(235)193-109(64-89-70-175-94-33-21-20-32-93(89)94)145(241)189-103(58-77(2)3)141(237)186-102(52-57-257-12)140(236)194-110(66-120(166)217)151(247)205-130(84(11)212)158(254)203-127(81(8)209)131(167)227)202-149(245)107(60-85-28-16-14-17-29-85)192-147(243)112(68-124(223)224)195-136(232)95(34-22-24-53-162)180-132(228)80(7)178-134(230)97(36-26-55-173-160(168)169)181-135(231)98(37-27-56-174-161(170)171)182-138(234)101(48-51-122(219)220)185-146(242)111(67-123(221)222)196-142(238)104(59-78(4)5)188-143(239)105(62-87-38-42-91(213)43-39-87)190-137(233)96(35-23-25-54-163)183-153(249)116(74-207)199-144(240)106(63-88-40-44-92(214)45-41-88)191-148(244)113(69-125(225)226)197-154(250)117(75-208)200-157(253)129(83(10)211)204-150(246)108(61-86-30-18-15-19-31-86)198-156(252)128(82(9)210)201-121(218)72-176-133(229)99(46-49-118(164)215)184-152(248)115(73-206)179-114(159(255)256)65-90-71-172-76-177-90/h14-21,28-33,38-45,70-71,76-84,95-117,126-130,175,179,206-214H,13,22-27,34-37,46-69,72-75,162-163H2,1-12H3,(H2,164,215)(H2,165,216)(H2,166,217)(H2,167,227)(H,172,177)(H,176,229)(H,178,230)(H,180,228)(H,181,231)(H,182,234)(H,183,249)(H,184,248)(H,185,242)(H,186,237)(H,187,251)(H,188,239)(H,189,241)(H,190,233)(H,191,244)(H,192,243)(H,193,235)(H,194,236)(H,195,232)(H,196,238)(H,197,250)(H,198,252)(H,199,240)(H,200,253)(H,201,218)(H,202,245)(H,203,254)(H,204,246)(H,205,247)(H,219,220)(H,221,222)(H,223,224)(H,225,226)(H,255,256)(H4,168,169,173)(H4,170,171,174)/t79-,80-,81+,82+,83+,84+,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,126-,127-,128-,129-,130-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0680n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324711
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C156H231N43O49S/c1-75(2)56-100(137(230)181-99(50-55-249-11)136(229)189-107(64-117(161)210)147(240)198-124(79(8)203)127(162)220)184-141(234)106(62-86-68-170-91-31-19-18-30-90(86)91)188-135(228)97(45-48-116(160)209)182-151(244)123(77(5)6)197-145(238)104(58-82-26-14-12-15-27-82)187-143(236)109(66-121(216)217)190-132(225)92(32-20-22-51-157)175-128(221)78(7)173-130(223)94(34-24-53-168-155(163)164)176-131(224)95(35-25-54-169-156(165)166)177-134(227)98(46-49-119(212)213)180-142(235)108(65-120(214)215)191-138(231)101(57-76(3)4)183-139(232)102(60-84-36-40-88(206)41-37-84)185-133(226)93(33-21-23-52-158)178-149(242)113(72-201)194-140(233)103(61-85-38-42-89(207)43-39-85)186-144(237)110(67-122(218)219)192-150(243)114(73-202)195-153(246)126(81(10)205)199-146(239)105(59-83-28-16-13-17-29-83)193-152(245)125(80(9)204)196-118(211)70-171-129(222)96(44-47-115(159)208)179-148(241)112(71-200)174-111(154(247)248)63-87-69-167-74-172-87/h12-19,26-31,36-43,68-69,74-81,92-114,123-126,170,174,200-207H,20-25,32-35,44-67,70-73,157-158H2,1-11H3,(H2,159,208)(H2,160,209)(H2,161,210)(H2,162,220)(H,167,172)(H,171,222)(H,173,223)(H,175,221)(H,176,224)(H,177,227)(H,178,242)(H,179,241)(H,180,235)(H,181,230)(H,182,244)(H,183,232)(H,184,234)(H,185,226)(H,186,237)(H,187,236)(H,188,228)(H,189,229)(H,190,225)(H,191,231)(H,192,243)(H,193,245)(H,194,233)(H,195,246)(H,196,211)(H,197,238)(H,198,240)(H,199,239)(H,212,213)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,163,164,168)(H4,165,166,169)/t78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-,126-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0710n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324714
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C155H227N41O50S/c1-74(2)55-99(137(228)178-98(50-54-247-11)136(227)186-106(63-117(161)208)147(238)195-124(78(8)200)127(162)218)181-141(232)105(61-85-67-167-90-30-19-18-29-89(85)90)185-135(226)96(44-48-116(160)207)179-151(242)123(76(5)6)194-145(236)103(57-81-25-14-12-15-26-81)184-143(234)108(65-121(214)215)187-131(222)91(31-20-22-51-156)172-128(219)77(7)170-130(221)93(33-24-53-166-155(163)164)173-133(224)95(43-47-115(159)206)176-134(225)97(45-49-119(210)211)177-142(233)107(64-120(212)213)188-138(229)100(56-75(3)4)180-139(230)101(59-83-34-38-87(203)39-35-83)182-132(223)92(32-21-23-52-157)174-149(240)112(71-198)191-140(231)102(60-84-36-40-88(204)41-37-84)183-144(235)109(66-122(216)217)189-150(241)113(72-199)192-153(244)126(80(10)202)196-146(237)104(58-82-27-16-13-17-28-82)190-152(243)125(79(9)201)193-118(209)69-168-129(220)94(42-46-114(158)205)175-148(239)111(70-197)171-110(154(245)246)62-86-68-165-73-169-86/h12-19,25-30,34-41,67-68,73-80,91-113,123-126,167,171,197-204H,20-24,31-33,42-66,69-72,156-157H2,1-11H3,(H2,158,205)(H2,159,206)(H2,160,207)(H2,161,208)(H2,162,218)(H,165,169)(H,168,220)(H,170,221)(H,172,219)(H,173,224)(H,174,240)(H,175,239)(H,176,225)(H,177,233)(H,178,228)(H,179,242)(H,180,230)(H,181,232)(H,182,223)(H,183,235)(H,184,234)(H,185,226)(H,186,227)(H,187,222)(H,188,229)(H,189,241)(H,190,243)(H,191,231)(H,192,244)(H,193,209)(H,194,236)(H,195,238)(H,196,237)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H,245,246)(H4,163,164,166)/t77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,123-,124-,125-,126-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0750n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324716
PNG
((2S,4S,7S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C157H233N43O49S/c1-76(2)58-102(139(232)183-101(52-57-250-11)138(231)191-109(66-118(162)211)148(241)199-125(80(8)204)128(163)221)186-143(236)108(64-87-69-171-92-31-19-18-30-91(87)92)190-136(229)98(45-49-117(161)210)184-152(245)124(78(5)6)198-146(239)106(60-83-26-14-12-15-27-83)188-137(230)100(47-51-121(215)216)181-132(225)93(32-20-22-53-158)176-129(222)79(7)174-131(224)95(34-24-55-169-156(164)165)177-133(226)96(35-25-56-170-157(166)167)178-135(228)99(46-50-120(213)214)182-144(237)110(67-122(217)218)192-140(233)103(59-77(3)4)185-141(234)104(62-85-36-40-89(207)41-37-85)187-134(227)94(33-21-23-54-159)179-150(243)114(73-202)195-142(235)105(63-86-38-42-90(208)43-39-86)189-145(238)111(68-123(219)220)193-151(244)115(74-203)196-154(247)127(82(10)206)200-147(240)107(61-84-28-16-13-17-29-84)194-153(246)126(81(9)205)197-119(212)71-172-130(223)97(44-48-116(160)209)180-149(242)113(72-201)175-112(155(248)249)65-88-70-168-75-173-88/h12-19,26-31,36-43,69-70,75-82,93-115,124-127,171,175,201-208H,20-25,32-35,44-68,71-74,158-159H2,1-11H3,(H2,160,209)(H2,161,210)(H2,162,211)(H2,163,221)(H,168,173)(H,172,223)(H,174,224)(H,176,222)(H,177,226)(H,178,228)(H,179,243)(H,180,242)(H,181,225)(H,182,237)(H,183,232)(H,184,245)(H,185,234)(H,186,236)(H,187,227)(H,188,230)(H,189,238)(H,190,229)(H,191,231)(H,192,233)(H,193,244)(H,194,246)(H,195,235)(H,196,247)(H,197,212)(H,198,239)(H,199,241)(H,200,240)(H,213,214)(H,215,216)(H,217,218)(H,219,220)(H,248,249)(H4,164,165,169)(H4,166,167,170)/t79-,80+,81+,82+,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,124-,125-,126-,127-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0750n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50261511
PNG
(CHEMBL507190 | c[Glu19-Lys23][Gly8]GLP-1(7-37)-NH2)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O
Show InChI InChI=1S/C147H227N41O45/c1-16-76(10)118(144(231)166-79(13)123(210)175-101(58-84-61-157-88-37-24-23-36-86(84)88)134(221)177-98(55-73(4)5)135(222)185-116(74(6)7)142(229)174-90(38-25-28-50-148)126(213)160-65-109(197)167-89(41-31-53-156-147(152)153)125(212)158-63-106(151)194)187-136(223)99(56-82-32-19-17-20-33-82)178-132(219)96(45-49-114(204)205)172-130(217)92(39-26-29-51-149)170-122(209)78(12)164-121(208)77(11)165-129(216)91-40-27-30-52-155-107(195)46-42-95(131(218)176-97(54-72(2)3)133(220)171-94(44-48-113(202)203)128(215)161-66-110(198)168-91)173-139(226)103(68-189)181-141(228)105(70-191)182-143(230)117(75(8)9)186-138(225)102(60-115(206)207)179-140(227)104(69-190)183-146(233)120(81(15)193)188-137(224)100(57-83-34-21-18-22-35-83)180-145(232)119(80(14)192)184-111(199)67-162-127(214)93(43-47-112(200)201)169-108(196)64-159-124(211)87(150)59-85-62-154-71-163-85/h17-24,32-37,61-62,71-81,87,89-105,116-120,157,189-193H,16,25-31,38-60,63-70,148-150H2,1-15H3,(H2,151,194)(H,154,163)(H,155,195)(H,158,212)(H,159,211)(H,160,213)(H,161,215)(H,162,214)(H,164,208)(H,165,216)(H,166,231)(H,167,197)(H,168,198)(H,169,196)(H,170,209)(H,171,220)(H,172,217)(H,173,226)(H,174,229)(H,175,210)(H,176,218)(H,177,221)(H,178,219)(H,179,227)(H,180,232)(H,181,228)(H,182,230)(H,183,233)(H,184,199)(H,185,222)(H,186,225)(H,187,223)(H,188,224)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H4,152,153,156)/t76-,77-,78-,79-,80+,81+,87-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,116-,117-,118-,119-,120-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0770n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as increase in cAMP level by cAMP-response element/luciferase activation assay


J Med Chem 51: 2758-65 (2008)


Article DOI: 10.1021/jm701522b
BindingDB Entry DOI: 10.7270/Q2736QPR
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324718
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C154H228N42O48S/c1-74(2)55-99(135(226)179-98(49-54-245-12)134(225)186-106(63-115(158)206)145(236)195-122(79(9)200)125(159)216)182-139(230)105(61-86-67-167-91-32-20-19-31-90(86)91)180-127(218)78(8)171-149(240)121(76(5)6)194-143(234)103(57-82-27-15-13-16-28-82)185-141(232)108(65-119(212)213)187-131(222)92(33-21-23-50-155)173-126(217)77(7)170-129(220)94(35-25-52-165-153(160)161)174-130(221)95(36-26-53-166-154(162)163)175-133(224)97(46-48-117(208)209)178-140(231)107(64-118(210)211)188-136(227)100(56-75(3)4)181-137(228)101(59-84-37-41-88(203)42-38-84)183-132(223)93(34-22-24-51-156)176-147(238)112(71-198)191-138(229)102(60-85-39-43-89(204)44-40-85)184-142(233)109(66-120(214)215)189-148(239)113(72-199)192-151(242)124(81(11)202)196-144(235)104(58-83-29-17-14-18-30-83)190-150(241)123(80(10)201)193-116(207)69-168-128(219)96(45-47-114(157)205)177-146(237)111(70-197)172-110(152(243)244)62-87-68-164-73-169-87/h13-20,27-32,37-44,67-68,73-81,92-113,121-124,167,172,197-204H,21-26,33-36,45-66,69-72,155-156H2,1-12H3,(H2,157,205)(H2,158,206)(H2,159,216)(H,164,169)(H,168,219)(H,170,220)(H,171,240)(H,173,217)(H,174,221)(H,175,224)(H,176,238)(H,177,237)(H,178,231)(H,179,226)(H,180,218)(H,181,228)(H,182,230)(H,183,223)(H,184,233)(H,185,232)(H,186,225)(H,187,222)(H,188,227)(H,189,239)(H,190,241)(H,191,229)(H,192,242)(H,193,207)(H,194,234)(H,195,236)(H,196,235)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H,243,244)(H4,160,161,165)(H4,162,163,166)/t77-,78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/an/a 0.0870n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50301952
PNG
((3S,6S,9S,12S,15S,21S)-21-(2-((S)-2-amino-3-(1H-im...)
Show SMILES CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2ccccc2F)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc2ccc(cc2)-c2ccccc2C)C(N)=O)cc1
Show InChI InChI=1S/C76H95FN14O19/c1-9-45-32-50(110-8)26-27-52(45)47-24-20-44(21-25-47)31-57(68(103)83-56(65(79)100)30-43-18-22-46(23-19-43)51-16-12-10-14-40(51)2)84-69(104)58(34-62(98)99)85-70(105)59(38-92)86-71(106)63(41(3)93)89-74(109)76(7,35-48-15-11-13-17-53(48)77)91-72(107)64(42(4)94)88-60(95)37-81-67(102)55(28-29-61(96)97)87-73(108)75(5,6)90-66(101)54(78)33-49-36-80-39-82-49/h10-27,32,36,39,41-42,54-59,63-64,92-94H,9,28-31,33-35,37-38,78H2,1-8H3,(H2,79,100)(H,80,82)(H,81,102)(H,83,103)(H,84,104)(H,85,105)(H,86,106)(H,87,108)(H,88,95)(H,89,109)(H,90,101)(H,91,107)(H,96,97)(H,98,99)/t41-,42-,54+,55+,56+,57+,58+,59+,63+,64+,76+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0870n/an/an/an/a



Bristol-Myers Squibb Company Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as stimulation of intracellular [3H]cAMP accumulation after 30 mins by scintillation ...


J Med Chem 52: 7788-99 (2009)


Article DOI: 10.1021/jm900752a
BindingDB Entry DOI: 10.7270/Q2VH5PRK
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Rattus norvegicus)
BDBM50393580
PNG
(CHEMBL2158410)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O
Show InChI InChI=1S/C186H275N51O59/c1-17-94(10)149(182(294)209-98(14)155(267)220-128(73-105-78-199-111-42-28-27-41-109(105)111)171(283)223-123(68-91(4)5)173(285)234-147(92(6)7)180(292)219-113(43-29-31-63-187)158(270)200-81-136(245)210-112(45-33-65-197-185(191)192)157(269)203-84-146(262)263)236-174(286)126(70-102-37-23-19-24-38-102)225-165(277)120(55-61-142(254)255)216-162(274)114(44-30-32-64-188)212-153(265)96(12)206-152(264)95(11)207-161(273)118(51-57-135(190)244)211-137(246)82-201-160(272)117(53-59-140(250)251)215-168(280)122(67-90(2)3)222-170(282)125(72-104-47-49-108(243)50-48-104)226-177(289)132(85-238)230-179(291)134(87-240)231-181(293)148(93(8)9)235-176(288)131(77-145(260)261)228-178(290)133(86-239)232-184(296)151(100(16)242)237-175(287)127(71-103-39-25-20-26-40-103)229-183(295)150(99(15)241)233-138(247)83-202-159(271)116(52-58-139(248)249)213-154(266)97(13)208-167(279)129(75-107-80-196-89-205-107)227-163(275)115(46-34-66-198-186(193)194)214-164(276)119(54-60-141(252)253)217-169(281)124(69-101-35-21-18-22-36-101)224-166(278)121(56-62-143(256)257)218-172(284)130(76-144(258)259)221-156(268)110(189)74-106-79-195-88-204-106/h18-28,35-42,47-50,78-80,88-100,110,112-134,147-151,199,238-243H,17,29-34,43-46,51-77,81-87,187-189H2,1-16H3,(H2,190,244)(H,195,204)(H,196,205)(H,200,270)(H,201,272)(H,202,271)(H,203,269)(H,206,264)(H,207,273)(H,208,279)(H,209,294)(H,210,245)(H,211,246)(H,212,265)(H,213,266)(H,214,276)(H,215,280)(H,216,274)(H,217,281)(H,218,284)(H,219,292)(H,220,267)(H,221,268)(H,222,282)(H,223,283)(H,224,278)(H,225,277)(H,226,289)(H,227,275)(H,228,290)(H,229,295)(H,230,291)(H,231,293)(H,232,296)(H,233,247)(H,234,285)(H,235,288)(H,236,286)(H,237,287)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H4,191,192,197)(H4,193,194,198)/t94-,95-,96-,97-,98-,99+,100+,110-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,147-,148-,149-,150-,151-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0900n/an/an/an/a



The National Center for Drug Screening

Curated by ChEMBL


Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ...


J Med Chem 55: 250-67 (2012)


Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50301953
PNG
((3S,6S,9S,12S,15S,21S)-21-(2-((S)-2-amino-3-(1H-im...)
Show SMILES CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2c(F)cccc2F)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc2ccc(cc2)-c2ccccc2C)C(N)=O)cc1
Show InChI InChI=1S/C76H94F2N14O19/c1-9-44-31-48(111-8)25-26-50(44)46-23-19-43(20-24-46)30-57(68(104)84-56(65(80)101)29-42-17-21-45(22-18-42)49-14-11-10-13-39(49)2)85-69(105)58(33-62(99)100)86-70(106)59(37-93)87-71(107)63(40(3)94)90-74(110)76(7,34-51-52(77)15-12-16-53(51)78)92-72(108)64(41(4)95)89-60(96)36-82-67(103)55(27-28-61(97)98)88-73(109)75(5,6)91-66(102)54(79)32-47-35-81-38-83-47/h10-26,31,35,38,40-41,54-59,63-64,93-95H,9,27-30,32-34,36-37,79H2,1-8H3,(H2,80,101)(H,81,83)(H,82,103)(H,84,104)(H,85,105)(H,86,106)(H,87,107)(H,88,109)(H,89,96)(H,90,110)(H,91,102)(H,92,108)(H,97,98)(H,99,100)/t40-,41-,54+,55+,56+,57+,58+,59+,63+,64+,76+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/an/a 0.0930n/an/an/an/a



Bristol-Myers Squibb Company Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as stimulation of intracellular [3H]cAMP accumulation after 30 mins by scintillation ...


J Med Chem 52: 7788-99 (2009)


Article DOI: 10.1021/jm900752a
BindingDB Entry DOI: 10.7270/Q2VH5PRK
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50241203
PNG
(CHEMBL414357 | HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGS...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C184H282N50O60S/c1-16-94(10)147(178(289)213-114(52-58-144(257)258)163(274)218-121(73-101-77-195-105-39-24-23-38-103(101)105)168(279)215-116(68-90(2)3)165(276)205-107(41-26-28-61-186)158(269)219-122(75-134(189)243)154(265)198-79-135(244)196-83-139(248)231-63-30-43-129(231)175(286)225-127(87-238)174(285)223-125(85-236)155(266)200-80-136(245)202-96(12)181(292)233-65-32-45-131(233)183(294)234-66-33-46-132(234)182(293)232-64-31-44-130(232)176(287)222-124(84-235)150(190)261)229-170(281)119(71-99-34-19-17-20-35-99)217-166(277)117(69-91(4)5)214-159(270)108(42-29-62-194-184(191)192)212-177(288)146(93(8)9)228-151(262)95(11)203-156(267)111(49-55-141(251)252)208-161(272)112(50-56-142(253)254)209-162(273)113(51-57-143(255)256)210-164(275)115(59-67-295-15)211-160(271)110(47-53-133(188)242)207-157(268)106(40-25-27-60-185)206-172(283)126(86-237)224-167(278)118(70-92(6)7)216-169(280)123(76-145(259)260)220-173(284)128(88-239)226-180(291)149(98(14)241)230-171(282)120(72-100-36-21-18-22-37-100)221-179(290)148(97(13)240)227-138(247)82-199-153(264)109(48-54-140(249)250)204-137(246)81-197-152(263)104(187)74-102-78-193-89-201-102/h17-24,34-39,77-78,89-98,104,106-132,146-149,195,235-241H,16,25-33,40-76,79-88,185-187H2,1-15H3,(H2,188,242)(H2,189,243)(H2,190,261)(H,193,201)(H,196,244)(H,197,263)(H,198,265)(H,199,264)(H,200,266)(H,202,245)(H,203,267)(H,204,246)(H,205,276)(H,206,283)(H,207,268)(H,208,272)(H,209,273)(H,210,275)(H,211,271)(H,212,288)(H,213,289)(H,214,270)(H,215,279)(H,216,280)(H,217,277)(H,218,274)(H,219,269)(H,220,284)(H,221,290)(H,222,287)(H,223,285)(H,224,278)(H,225,286)(H,226,291)(H,227,247)(H,228,262)(H,229,281)(H,230,282)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,191,192,194)/t94-,95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.100n/an/an/an/a



Shionogi and Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GLP-1 receptor expressed in CHO cells assessed as increase in cAMP production


Bioorg Med Chem Lett 20: 4631-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.002
BindingDB Entry DOI: 10.7270/Q21Z44MT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273762
PNG
((4S,7S,10S,13S,16S,22S,25S,28S,31S,34S,37S,40S,43S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C153H232N42O47/c1-15-78(8)123(150(240)186-104(60-85-31-18-16-19-32-85)139(229)172-81(11)129(219)182-107(63-88-66-165-93-36-23-22-35-91(88)93)141(231)183-103(59-75(2)3)142(232)192-121(76(4)5)148(238)181-95(37-24-27-55-154)131(221)166-68-114(205)173-94(126(159)216)40-30-58-164-153(160)161)194-138(228)102(49-54-119(212)213)180-135(225)96(38-25-28-56-155)175-128(218)80(10)171-134(224)101(46-51-113(158)204)179-137(227)100(45-50-112(157)203)174-115(206)69-167-133(223)99(48-53-118(210)211)178-136(226)97(39-26-29-57-163-84(14)201)177-140(230)105(62-87-41-43-90(202)44-42-87)184-145(235)109(71-196)188-147(237)111(73-198)189-149(239)122(77(6)7)193-144(234)108(65-120(214)215)185-146(236)110(72-197)190-152(242)125(83(13)200)195-143(233)106(61-86-33-20-17-21-34-86)187-151(241)124(82(12)199)191-116(207)70-168-132(222)98(47-52-117(208)209)176-127(217)79(9)170-130(220)92(156)64-89-67-162-74-169-89/h16-23,31-36,41-44,66-67,74-83,92,94-111,121-125,165,196-200,202H,15,24-30,37-40,45-65,68-73,154-156H2,1-14H3,(H2,157,203)(H2,158,204)(H2,159,216)(H,162,169)(H,163,201)(H,166,221)(H,167,223)(H,168,222)(H,170,220)(H,171,224)(H,172,229)(H,173,205)(H,174,206)(H,175,218)(H,176,217)(H,177,230)(H,178,226)(H,179,227)(H,180,225)(H,181,238)(H,182,219)(H,183,231)(H,184,235)(H,185,236)(H,186,240)(H,187,241)(H,188,237)(H,189,239)(H,190,242)(H,191,207)(H,192,232)(H,193,234)(H,194,228)(H,195,233)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H4,160,161,164)/t78-,79-,80-,81-,82+,83+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-,125-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.102n/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Activation of human GLP1R expressed in HEK293 cells assessed as effect on cAMP responsive element promoter driven luciferase expression


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324720
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C155H226N42O51S/c1-73(2)54-98(136(230)179-97(49-53-249-11)135(229)187-105(62-115(159)208)146(240)196-123(77(8)201)126(160)220)182-140(234)104(60-84-66-168-89-29-19-18-28-88(84)89)186-134(228)95(42-46-114(158)207)180-150(244)122(75(5)6)195-144(238)102(56-80-24-14-12-15-25-80)185-142(236)107(64-120(216)217)188-133(227)94(41-45-113(157)206)173-127(221)76(7)171-129(223)91(31-22-51-166-154(161)162)174-130(224)92(32-23-52-167-155(163)164)175-132(226)96(44-48-118(212)213)178-141(235)106(63-119(214)215)189-137(231)99(55-74(3)4)181-138(232)100(58-82-33-37-86(204)38-34-82)183-131(225)90(30-20-21-50-156)176-148(242)111(70-199)192-139(233)101(59-83-35-39-87(205)40-36-83)184-143(237)108(65-121(218)219)190-149(243)112(71-200)193-152(246)125(79(10)203)197-145(239)103(57-81-26-16-13-17-27-81)191-151(245)124(78(9)202)194-116(209)68-169-128(222)93(43-47-117(210)211)177-147(241)110(69-198)172-109(153(247)248)61-85-67-165-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,168,172,198-205H,20-23,30-32,41-65,68-71,156H2,1-11H3,(H2,157,206)(H2,158,207)(H2,159,208)(H2,160,220)(H,165,170)(H,169,222)(H,171,223)(H,173,221)(H,174,224)(H,175,226)(H,176,242)(H,177,241)(H,178,235)(H,179,230)(H,180,244)(H,181,232)(H,182,234)(H,183,225)(H,184,237)(H,185,236)(H,186,228)(H,187,229)(H,188,227)(H,189,231)(H,190,243)(H,191,245)(H,192,233)(H,193,246)(H,194,209)(H,195,238)(H,196,240)(H,197,239)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,161,162,166)(H4,163,164,167)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.110n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50324707
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCS(O)(=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C154H227N43O51S2/c1-73(2)54-98(135(227)178-96(47-52-249-11)133(225)187-105(62-116(159)209)145(237)196-122(77(8)201)125(160)217)182-139(231)104(60-84-66-168-89-29-19-18-28-88(84)89)186-132(224)95(43-46-115(158)208)180-149(241)121(75(5)6)195-143(235)102(56-80-24-14-12-15-25-80)185-141(233)107(64-119(213)214)188-131(223)94(42-45-114(157)207)173-126(218)76(7)171-128(220)91(31-22-50-166-153(161)162)174-129(221)92(32-23-51-167-154(163)164)175-134(226)97(48-53-250(246,247)248)179-140(232)106(63-118(211)212)189-136(228)99(55-74(3)4)181-137(229)100(58-82-33-37-86(204)38-34-82)183-130(222)90(30-20-21-49-155)176-147(239)111(70-199)192-138(230)101(59-83-35-39-87(205)40-36-83)184-142(234)108(65-120(215)216)190-148(240)112(71-200)193-151(243)124(79(10)203)197-144(236)103(57-81-26-16-13-17-27-81)191-150(242)123(78(9)202)194-117(210)68-169-127(219)93(41-44-113(156)206)177-146(238)110(69-198)172-109(152(244)245)61-85-67-165-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,121-124,168,172,198-205H,20-23,30-32,41-65,68-71,155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,217)(H,165,170)(H,169,219)(H,171,220)(H,173,218)(H,174,221)(H,175,226)(H,176,239)(H,177,238)(H,178,227)(H,179,232)(H,180,241)(H,181,229)(H,182,231)(H,183,222)(H,184,234)(H,185,233)(H,186,224)(H,187,225)(H,188,223)(H,189,228)(H,190,240)(H,191,242)(H,192,230)(H,193,243)(H,194,210)(H,195,235)(H,196,237)(H,197,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,161,162,166)(H4,163,164,167)(H,246,247,248)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.120n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50086603
PNG
(CHEMBL3426241)
Show SMILES CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2ccccc2F)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCc2ccccc2)C(N)=O)cc1
Show InChI InChI=1S/C71H93FN14O19/c1-8-42-30-46(105-7)25-26-47(42)43-23-21-41(22-24-43)29-52(63(98)78-50(60(74)95)20-14-17-40-15-10-9-11-16-40)79-64(99)53(32-57(93)94)80-65(100)54(36-87)81-66(101)58(38(2)88)84-69(104)71(6,33-44-18-12-13-19-48(44)72)86-67(102)59(39(3)89)83-55(90)35-76-62(97)51(27-28-56(91)92)82-68(103)70(4,5)85-61(96)49(73)31-45-34-75-37-77-45/h9-13,15-16,18-19,21-26,30,34,37-39,49-54,58-59,87-89H,8,14,17,20,27-29,31-33,35-36,73H2,1-7H3,(H2,74,95)(H,75,77)(H,76,97)(H,78,98)(H,79,99)(H,80,100)(H,81,101)(H,82,103)(H,83,90)(H,84,104)(H,85,96)(H,86,102)(H,91,92)(H,93,94)/t38-,39-,49+,50+,51+,52+,53+,54+,58+,59+,71+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.120n/an/an/an/a



University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP-1R expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins


J Med Chem 58: 4080-5 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00166
BindingDB Entry DOI: 10.7270/Q2DB83KP
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273764
PNG
((4S,7S,10S,13S,16S,22S,25S,28S,31S,34S,37S,40S,43S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C154H236N42O45/c1-17-80(10)124(151(239)187-106(61-87-33-20-18-21-34-87)139(227)173-83(13)130(218)182-109(64-90-67-166-95-38-25-24-37-93(90)95)142(230)184-105(60-77(4)5)143(231)193-122(78(6)7)149(237)181-98(39-26-29-55-155)133(221)167-69-116(206)174-96(127(160)215)42-32-58-165-154(161)162)195-138(226)103(50-54-120(211)212)180-136(224)99(40-27-30-56-156)179-137(225)102(48-52-115(159)205)177-129(217)82(12)172-135(223)101(47-51-114(158)204)175-117(207)70-168-132(220)97(41-28-31-57-164-86(16)202)178-140(228)104(59-76(2)3)183-141(229)107(63-89-43-45-92(203)46-44-89)185-146(234)111(72-197)189-148(236)113(74-199)190-150(238)123(79(8)9)194-145(233)110(66-121(213)214)186-147(235)112(73-198)191-153(241)126(85(15)201)196-144(232)108(62-88-35-22-19-23-36-88)188-152(240)125(84(14)200)192-118(208)71-169-134(222)100(49-53-119(209)210)176-128(216)81(11)171-131(219)94(157)65-91-68-163-75-170-91/h18-25,33-38,43-46,67-68,75-85,94,96-113,122-126,166,197-201,203H,17,26-32,39-42,47-66,69-74,155-157H2,1-16H3,(H2,158,204)(H2,159,205)(H2,160,215)(H,163,170)(H,164,202)(H,167,221)(H,168,220)(H,169,222)(H,171,219)(H,172,223)(H,173,227)(H,174,206)(H,175,207)(H,176,216)(H,177,217)(H,178,228)(H,179,225)(H,180,224)(H,181,237)(H,182,218)(H,183,229)(H,184,230)(H,185,234)(H,186,235)(H,187,239)(H,188,240)(H,189,236)(H,190,238)(H,191,241)(H,192,208)(H,193,231)(H,194,233)(H,195,226)(H,196,232)(H,209,210)(H,211,212)(H,213,214)(H4,161,162,165)/t80-,81-,82-,83-,84+,85+,94-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-,126-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.123n/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Activation of human GLP1R expressed in HEK293 cells assessed as effect on cAMP responsive element promoter driven luciferase expression


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
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