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Compile Data Set for Download or QSAR

Found 1795 hits Enz. Inhib. hit(s) with Target = 'Glucose-dependent insulinotropic receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342703
PNG
(CHEMBL1771104 | rac-4-(3-(2-(3-(1-(5-chloropyrimid...)
Show SMILES Fc1cc(OCCCC2CC2CCCC2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C28H36ClFN4O2/c29-22-17-31-28(32-18-22)34-12-10-19(11-13-34)3-1-4-20-15-21(20)5-2-14-36-24-8-9-25(26(30)16-24)27(35)33-23-6-7-23/h8-9,16-21,23H,1-7,10-15H2,(H,33,35)
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n/an/an/an/a 0.200n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342697
PNG
((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Show SMILES Fc1cc(OCCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-17-13-27-24(28-14-17)30-8-5-15(6-9-30)21-11-16(21)7-10-32-19-3-4-20(22(26)12-19)23(31)29-18-1-2-18/h3-4,12-16,18,21H,1-2,5-11H2,(H,29,31)
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n/an/an/an/a 0.300n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342697
PNG
((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Show SMILES Fc1cc(OCCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-17-13-27-24(28-14-17)30-8-5-15(6-9-30)21-11-16(21)7-10-32-19-3-4-20(22(26)12-19)23(31)29-18-1-2-18/h3-4,12-16,18,21H,1-2,5-11H2,(H,29,31)
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n/an/an/an/a 0.400n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50036640
PNG
(CHEMBL3354778)
Show SMILES CCOC(=O)[C@@]1(Cc2ccccc2)CCc2cnc3c(cnn3c12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H22F3N3O2/c1-2-34-24(33)25(14-17-6-4-3-5-7-17)13-12-19-15-30-23-21(16-31-32(23)22(19)25)18-8-10-20(11-9-18)26(27,28)29/h3-11,15-16H,2,12-14H2,1H3/t25-/m1/s1
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n/an/an/an/a 0.5n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF method


Bioorg Med Chem Lett 24: 5478-83 (2015)


Article DOI: 10.1016/j.bmcl.2014.10.010
BindingDB Entry DOI: 10.7270/Q29C7019
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343443
PNG
(CHEMBL1773283 | tert-butyl 4-(1-(2-fluoro-4-(methy...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Sc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H26FN5O4S2/c1-22(2,3)32-21(29)27-9-7-14(8-10-27)33-20-16-12-26-28(19(16)24-13-25-20)18-6-5-15(11-17(18)23)34(4,30)31/h5-6,11-14H,7-10H2,1-4H3
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343444
PNG
(CHEMBL1773292 | tert-butyl 4-(9-(2-fluoro-4-(methy...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(-c3ccc(cc3F)S(C)(=O)=O)c(=O)[nH]c12
Show InChI InChI=1S/C22H26FN5O6S/c1-22(2,3)34-21(30)27-9-7-13(8-10-27)33-19-17-18(24-12-25-19)28(20(29)26-17)16-6-5-14(11-15(16)23)35(4,31)32/h5-6,11-13H,7-10H2,1-4H3,(H,26,29)
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n/an/an/an/a 0.600n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50204219
PNG
(CHEMBL3893596)
Show SMILES CC(C)OC(=O)N1[C@@H]2CC[C@@H]1CC(C2)Oc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C22H26FN5O7S/c1-12(2)34-22(29)27-13-4-5-14(27)9-15(8-13)35-21-19(28(30)31)20(24-11-25-21)26-18-7-6-16(10-17(18)23)36(3,32)33/h6-7,10-15H,4-5,8-9H2,1-3H3,(H,24,25,26)/t13-,14-/m1/s1
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n/an/an/an/a 0.600n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level measured after 60 mins by HTRF assay


Bioorg Med Chem 25: 254-260 (2017)


Article DOI: 10.1016/j.bmc.2016.10.030
BindingDB Entry DOI: 10.7270/Q2Z321MK
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50244791
PNG
((2-Fluoro-4-methanesulfonyl-phenyl)-{6-[4-(3-isopr...)
Show SMILES CC(C)c1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25)
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n/an/an/an/a 0.650n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50244791
PNG
((2-Fluoro-4-methanesulfonyl-phenyl)-{6-[4-(3-isopr...)
Show SMILES CC(C)c1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25)
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n/an/an/an/a 0.680n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation


J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343445
PNG
(CHEMBL1773293 | tert-butyl 4-(3-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2c(noc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H26N4O6S/c1-22(2,3)31-21(27)26-11-9-15(10-12-26)30-20-19-18(23-13-24-20)17(25-32-19)14-5-7-16(8-6-14)33(4,28)29/h5-8,13,15H,9-12H2,1-4H3
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n/an/an/an/a 0.700n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342703
PNG
(CHEMBL1771104 | rac-4-(3-(2-(3-(1-(5-chloropyrimid...)
Show SMILES Fc1cc(OCCCC2CC2CCCC2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C28H36ClFN4O2/c29-22-17-31-28(32-18-22)34-12-10-19(11-13-34)3-1-4-20-15-21(20)5-2-14-36-24-8-9-25(26(30)16-24)27(35)33-23-6-7-23/h8-9,16-21,23H,1-7,10-15H2,(H,33,35)
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n/an/an/an/a 0.800n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50122947
PNG
(CHEMBL3622182)
Show SMILES CCS(=O)(=O)c1ccc(COC[C@@H]2C[C@@H]2C2CCN(CC2)c2nc(no2)C(C)C)c(F)c1
Show InChI InChI=1S/C23H32FN3O4S/c1-4-32(28,29)19-6-5-17(21(24)12-19)13-30-14-18-11-20(18)16-7-9-27(10-8-16)23-25-22(15(2)3)26-31-23/h5-6,12,15-16,18,20H,4,7-11,13-14H2,1-3H3/t18-,20+/m0/s1
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n/an/an/an/a 0.800n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells by cAMP assay


ACS Med Chem Lett 6: 936-41 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00207
BindingDB Entry DOI: 10.7270/Q2BK1F5K
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343446
PNG
(CHEMBL1775178 | tert-butyl 4-(1-(2-fluoro-4-(methy...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H26FN5O5S/c1-22(2,3)33-21(29)27-9-7-14(8-10-27)32-20-16-12-26-28(19(16)24-13-25-20)18-6-5-15(11-17(18)23)34(4,30)31/h5-6,11-14H,7-10H2,1-4H3
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n/an/an/an/a 0.900n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50036636
PNG
(CHEMBL3354774)
Show SMILES CCOC(=O)[C@](C)(Cc1ccccc1)c1c(C)cnc2c(cnn12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H24F3N3O2/c1-4-34-24(33)25(3,14-18-8-6-5-7-9-18)22-17(2)15-30-23-21(16-31-32(22)23)19-10-12-20(13-11-19)26(27,28)29/h5-13,15-16H,4,14H2,1-3H3/t25-/m1/s1
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n/an/an/an/a 1n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF method


Bioorg Med Chem Lett 24: 5478-83 (2015)


Article DOI: 10.1016/j.bmcl.2014.10.010
BindingDB Entry DOI: 10.7270/Q29C7019
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50013912
PNG
(CHEMBL3260536)
Show SMILES COCCN(C)C(=O)C(C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C27H27F3N4O2/c1-26(17-19-7-5-4-6-8-19,25(35)33(2)15-16-36-3)23-13-14-31-24-22(18-32-34(23)24)20-9-11-21(12-10-20)27(28,29)30/h4-14,18H,15-17H2,1-3H3
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Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay


Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342680
PNG
(CHEMBL1771081 | tert-butyl 1'-(2-cyano-6-methylpyr...)
Show SMILES Cc1cc(nc(n1)C#N)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C21H31N5O2/c1-15-13-19(24-18(14-22)23-15)25-9-5-16(6-10-25)17-7-11-26(12-8-17)20(27)28-21(2,3)4/h13,16-17H,5-12H2,1-4H3
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343447
PNG
(CHEMBL1775169 | tert-butyl 4-(1-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N5O5S/c1-22(2,3)32-21(28)26-11-9-16(10-12-26)31-20-18-13-25-27(19(18)23-14-24-20)15-5-7-17(8-6-15)33(4,29)30/h5-8,13-14,16H,9-12H2,1-4H3
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n/an/an/an/a 1.10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50122756
PNG
(CHEMBL3622179)
Show SMILES COCc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1COCc1ccc(c(F)c1)-n1cnnn1
Show InChI InChI=1S/C23H28FN7O2/c1-32-12-17-10-25-23(26-11-17)30-6-4-18(5-7-30)20-9-19(20)14-33-13-16-2-3-22(21(24)8-16)31-15-27-28-29-31/h2-3,8,10-11,15,18-20H,4-7,9,12-14H2,1H3/t19-,20+/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells by cAMP assay


ACS Med Chem Lett 6: 936-41 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00207
BindingDB Entry DOI: 10.7270/Q2BK1F5K
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106208
PNG
(CHEMBL3598101)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)cn1
Show InChI InChI=1S/C20H25F6N3O6S/c1-36(31,32)16-11-27-15(10-28-16)34-13-4-2-12(3-5-13)33-14-6-8-29(9-7-14)18(30)35-17(19(21,22)23)20(24,25)26/h10-14,17H,2-9H2,1H3/t12-,13-
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n/an/an/an/a 1.20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50204225
PNG
(CHEMBL3912040)
Show SMILES CC(C)(C)OC(=O)N1[C@@H]2CC[C@@H]1CC(C2)Nc1ncnc(Nc2ccc(cc2F)C#N)c1[N+]([O-])=O
Show InChI InChI=1S/C23H26FN7O4/c1-23(2,3)35-22(32)30-15-5-6-16(30)10-14(9-15)28-20-19(31(33)34)21(27-12-26-20)29-18-7-4-13(11-25)8-17(18)24/h4,7-8,12,14-16H,5-6,9-10H2,1-3H3,(H2,26,27,28,29)/t15-,16-/m1/s1
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n/an/an/an/a 1.30n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level measured after 60 mins by HTRF assay


Bioorg Med Chem 25: 254-260 (2017)


Article DOI: 10.1016/j.bmc.2016.10.030
BindingDB Entry DOI: 10.7270/Q2Z321MK
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50204229
PNG
(CHEMBL3982536)
Show SMILES CCOC(=O)N1[C@@H]2CC[C@@H]1CC(C2)Oc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C21H24FN5O7S/c1-3-33-21(28)26-12-4-5-13(26)9-14(8-12)34-20-18(27(29)30)19(23-11-24-20)25-17-7-6-15(10-16(17)22)35(2,31)32/h6-7,10-14H,3-5,8-9H2,1-2H3,(H,23,24,25)/t12-,13-/m1/s1
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n/an/an/an/a 1.40n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level measured after 60 mins by HTRF assay


Bioorg Med Chem 25: 254-260 (2017)


Article DOI: 10.1016/j.bmc.2016.10.030
BindingDB Entry DOI: 10.7270/Q2Z321MK
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50427059
PNG
(CHEMBL2322837)
Show SMILES CC(C)(C)OC(=O)N1[C@H]2CC[C@H]1CC(C2)Oc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C23H28FN5O7S/c1-23(2,3)36-22(30)28-13-5-6-14(28)10-15(9-13)35-21-19(29(31)32)20(25-12-26-21)27-18-8-7-16(11-17(18)24)37(4,33)34/h7-8,11-15H,5-6,9-10H2,1-4H3,(H,25,26,27)/t13-,14-/m0/s1
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n/an/an/an/a 1.40n/an/an/an/a



College of Pharmacy of Kangwon National University

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 transfected in HEK293 cells assessed as concentration for 50 % cAMP stimulation of oleylethanolamine


Bioorg Med Chem Lett 23: 1519-21 (2013)


Article DOI: 10.1016/j.bmcl.2012.12.011
BindingDB Entry DOI: 10.7270/Q2SQ91Q7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50122875
PNG
(CHEMBL3622170)
Show SMILES COc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1COCc1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H28FN3O4S/c1-29-18-11-24-22(25-12-18)26-7-5-15(6-8-26)20-9-17(20)14-30-13-16-3-4-19(10-21(16)23)31(2,27)28/h3-4,10-12,15,17,20H,5-9,13-14H2,1-2H3/t17-,20+/m0/s1
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n/an/an/an/a 1.40n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 by cAMP assay


ACS Med Chem Lett 6: 936-41 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00207
BindingDB Entry DOI: 10.7270/Q2BK1F5K
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50244681
PNG
(CHEMBL518819 | {6-[4-(3-tert-Butyl-[1,2,4]oxadiazo...)
Show SMILES CC(C)(C)c1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C22H27N7O5S/c1-22(2,3)21-26-20(34-27-21)14-9-11-28(12-10-14)19-17(29(30)31)18(23-13-24-19)25-15-5-7-16(8-6-15)35(4,32)33/h5-8,13-14H,9-12H2,1-4H3,(H,23,24,25)
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n/an/an/an/a 1.5n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation


J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50204231
PNG
(CHEMBL3951013)
Show SMILES CC(C)(C)OC(=O)N1[C@@H]2CC[C@@H]1CC(C2)Oc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C23H28FN5O7S/c1-23(2,3)36-22(30)28-13-5-6-14(28)10-15(9-13)35-21-19(29(31)32)20(25-12-26-21)27-18-8-7-16(11-17(18)24)37(4,33)34/h7-8,11-15H,5-6,9-10H2,1-4H3,(H,25,26,27)/t13-,14-/m1/s1
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n/an/an/an/a 1.5n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level measured after 60 mins by HTRF assay


Bioorg Med Chem 25: 254-260 (2017)


Article DOI: 10.1016/j.bmc.2016.10.030
BindingDB Entry DOI: 10.7270/Q2Z321MK
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50427063
PNG
(CHEMBL2322841)
Show SMILES CC(C)(C)OC(=O)N1[C@H]2CC[C@H]1CC(C2)Nc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C23H29FN6O6S/c1-23(2,3)36-22(31)29-14-5-6-15(29)10-13(9-14)27-20-19(30(32)33)21(26-12-25-20)28-18-8-7-16(11-17(18)24)37(4,34)35/h7-8,11-15H,5-6,9-10H2,1-4H3,(H2,25,26,27,28)/t14-,15-/m0/s1
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n/an/an/an/a 1.5n/an/an/an/a



College of Pharmacy of Kangwon National University

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 transfected in HEK293 cells assessed as concentration for 50 % cAMP stimulation of oleylethanolamine


Bioorg Med Chem Lett 23: 1519-21 (2013)


Article DOI: 10.1016/j.bmcl.2012.12.011
BindingDB Entry DOI: 10.7270/Q2SQ91Q7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50427059
PNG
(CHEMBL2322837)
Show SMILES CC(C)(C)OC(=O)N1[C@H]2CC[C@H]1CC(C2)Oc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C23H28FN5O7S/c1-23(2,3)36-22(30)28-13-5-6-14(28)10-15(9-13)35-21-19(29(31)32)20(25-12-26-21)27-18-8-7-16(11-17(18)24)37(4,33)34/h7-8,11-15H,5-6,9-10H2,1-4H3,(H,25,26,27)/t13-,14-/m0/s1
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n/an/an/an/a 1.5n/an/an/an/a



College of Pharmacy of Kangwon National University

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 transfected in HEK293 cells assessed as concentration for 50 % cAMP stimulation of oleylethanolamine


Bioorg Med Chem Lett 23: 1519-21 (2013)


Article DOI: 10.1016/j.bmcl.2012.12.011
BindingDB Entry DOI: 10.7270/Q2SQ91Q7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50204226
PNG
(CHEMBL3914281)
Show SMILES CC(C)(C)OC(=O)N1[C@@H]2CC[C@@H]1CC(C2)Nc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C23H29FN6O6S/c1-23(2,3)36-22(31)29-14-5-6-15(29)10-13(9-14)27-20-19(30(32)33)21(26-12-25-20)28-18-8-7-16(11-17(18)24)37(4,34)35/h7-8,11-15H,5-6,9-10H2,1-4H3,(H2,25,26,27,28)/t14-,15-/m1/s1
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Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level measured after 60 mins by HTRF assay


Bioorg Med Chem 25: 254-260 (2017)


Article DOI: 10.1016/j.bmc.2016.10.030
BindingDB Entry DOI: 10.7270/Q2Z321MK
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50122933
PNG
(CHEMBL3622166)
Show SMILES CCc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1COCc1ccc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C22H30N4O3S/c1-3-16-11-24-22(25-12-16)26-8-6-17(7-9-26)21-10-18(21)14-29-15-19-4-5-20(13-23-19)30(2,27)28/h4-5,11-13,17-18,21H,3,6-10,14-15H2,1-2H3/t18-,21+/m0/s1
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n/an/an/an/a 1.5n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells by cAMP assay


ACS Med Chem Lett 6: 936-41 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00207
BindingDB Entry DOI: 10.7270/Q2BK1F5K
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50204223
PNG
(CHEMBL3904015)
Show SMILES CS(=O)(=O)N1[C@@H]2CC[C@@H]1CC(C2)Oc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C19H22FN5O7S2/c1-33(28,29)14-5-6-16(15(20)9-14)23-18-17(25(26)27)19(22-10-21-18)32-13-7-11-3-4-12(8-13)24(11)34(2,30)31/h5-6,9-13H,3-4,7-8H2,1-2H3,(H,21,22,23)/t11-,12-/m1/s1
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n/an/an/an/a 1.60n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level measured after 60 mins by HTRF assay


Bioorg Med Chem 25: 254-260 (2017)


Article DOI: 10.1016/j.bmc.2016.10.030
BindingDB Entry DOI: 10.7270/Q2Z321MK
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50122936
PNG
(CHEMBL3622181)
Show SMILES CCS(=O)(=O)c1ccc(OCC[C@@H]2C[C@@H]2C2CCN(CC2)c2nc(no2)C(C)C)c(F)c1
Show InChI InChI=1S/C23H32FN3O4S/c1-4-32(28,29)18-5-6-21(20(24)14-18)30-12-9-17-13-19(17)16-7-10-27(11-8-16)23-25-22(15(2)3)26-31-23/h5-6,14-17,19H,4,7-13H2,1-3H3/t17-,19-/m1/s1
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n/an/an/an/a 1.70n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells by cAMP assay


ACS Med Chem Lett 6: 936-41 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00207
BindingDB Entry DOI: 10.7270/Q2BK1F5K
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50122934
PNG
(CHEMBL3622165)
Show SMILES OCCS(=O)(=O)c1ccc(COC[C@@H]2C[C@@H]2C2CCN(CC2)c2ncc(Cl)cn2)c(F)c1
Show InChI InChI=1S/C22H27ClFN3O4S/c23-18-11-25-22(26-12-18)27-5-3-15(4-6-27)20-9-17(20)14-31-13-16-1-2-19(10-21(16)24)32(29,30)8-7-28/h1-2,10-12,15,17,20,28H,3-9,13-14H2/t17-,20+/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 by cAMP assay


ACS Med Chem Lett 6: 936-41 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00207
BindingDB Entry DOI: 10.7270/Q2BK1F5K
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50122931
PNG
(CHEMBL3622168)
Show SMILES CC(C)c1noc(n1)N1CCC(CC1)[C@H]1C[C@H]1COCc1ccc(cc1F)-n1cnnn1
Show InChI InChI=1S/C22H28FN7O2/c1-14(2)21-25-22(32-26-21)29-7-5-15(6-8-29)19-9-17(19)12-31-11-16-3-4-18(10-20(16)23)30-13-24-27-28-30/h3-4,10,13-15,17,19H,5-9,11-12H2,1-2H3/t17-,19+/m0/s1
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n/an/an/an/a 1.70n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells by cAMP assay


ACS Med Chem Lett 6: 936-41 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00207
BindingDB Entry DOI: 10.7270/Q2BK1F5K
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50122870
PNG
(CHEMBL3622171)
Show SMILES CCOc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1COCc1ccc(c(F)c1)S(C)(=O)=O
Show InChI InChI=1S/C23H30FN3O4S/c1-3-31-19-12-25-23(26-13-19)27-8-6-17(7-9-27)20-11-18(20)15-30-14-16-4-5-22(21(24)10-16)32(2,28)29/h4-5,10,12-13,17-18,20H,3,6-9,11,14-15H2,1-2H3/t18-,20+/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells by cAMP assay


ACS Med Chem Lett 6: 936-41 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00207
BindingDB Entry DOI: 10.7270/Q2BK1F5K
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50122844
PNG
(CHEMBL3622175)
Show SMILES COCc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1COCc1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H30FN3O4S/c1-30-13-16-11-25-23(26-12-16)27-7-5-17(6-8-27)21-9-19(21)15-31-14-18-3-4-20(10-22(18)24)32(2,28)29/h3-4,10-12,17,19,21H,5-9,13-15H2,1-2H3/t19-,21+/m0/s1
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n/an/an/an/a 1.90n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 by cAMP assay


ACS Med Chem Lett 6: 936-41 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00207
BindingDB Entry DOI: 10.7270/Q2BK1F5K
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50420833
PNG
(CHEMBL2086693)
Show SMILES C[C@@H]1CN(CCN1c1ncc(OCc2ccncc2C#N)cn1)c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C19H17F3N8O2/c1-12-10-29(18-27-16(32-28-18)19(20,21)22)4-5-30(12)17-25-8-15(9-26-17)31-11-13-2-3-24-7-14(13)6-23/h2-3,7-9,12H,4-5,10-11H2,1H3/t12-/m1/s1
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n/an/an/an/a 2n/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor over expressed in HEK293S cells assessed as increase in cAMP level after 45 mins by HTRF assay


J Med Chem 55: 5361-79 (2012)


Article DOI: 10.1021/jm300310c
BindingDB Entry DOI: 10.7270/Q2PZ5B3V
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM254730
PNG
(US9469631, 40)
Show SMILES CC(C)(C)OC(=O)N1CC[C@@H]([C@H](F)C1)N(C1CC1)C(=O)c1ccc(cc1)-c1cnco1
Show InChI InChI=1S/C23H28FN3O4/c1-23(2,3)31-22(29)26-11-10-19(18(24)13-26)27(17-8-9-17)21(28)16-6-4-15(5-7-16)20-12-25-14-30-20/h4-7,12,14,17-19H,8-11,13H2,1-3H3/t18-,19+/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] are stably transfected with an expression vector for human GPR119 cDNA (Acc. N...


US Patent US9469631 (2016)


BindingDB Entry DOI: 10.7270/Q2V40T4G
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400771
PNG
(CHEMBL2204975)
Show SMILES CCc1cnc(nc1)N1CCC(CC1)C1Cc2cc(ncc2O1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C24H33N5O3S/c1-3-17-14-26-24(27-15-17)28-8-4-19(5-9-28)22-13-20-12-21(25-16-23(20)32-22)18-6-10-29(11-7-18)33(2,30)31/h12,14-16,18-19,22H,3-11,13H2,1-2H3
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TBA

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in MIN6 cells assessed as intracellular cAMP concentration after 45 mins by Alphascreen analysis


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400767
PNG
(CHEMBL2204979)
Show SMILES CS(=O)(=O)N1CCC(=CC1)c1cc2C[C@@H](Oc2cn1)C1CCN(CC1)c1ncc(cc1F)C(F)(F)F
Show InChI InChI=1S/C24H26F4N4O3S/c1-36(33,34)32-8-4-15(5-9-32)20-10-17-11-21(35-22(17)14-29-20)16-2-6-31(7-3-16)23-19(25)12-18(13-30-23)24(26,27)28/h4,10,12-14,16,21H,2-3,5-9,11H2,1H3/t21-/m1/s1
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n/an/an/an/a 2n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in MIN6 cells assessed as intracellular cAMP concentration after 45 mins by Alphascreen analysis


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50036671
PNG
(CHEMBL3354804)
Show SMILES OCc1nn2c3c(CN[C@]3(Cc3cccc(F)c3)C3CC3)cnc2c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H22F4N4O/c27-20-3-1-2-15(10-20)11-25(18-8-9-18)23-17(13-32-25)12-31-24-22(21(14-35)33-34(23)24)16-4-6-19(7-5-16)26(28,29)30/h1-7,10,12,18,32,35H,8-9,11,13-14H2/t25-/m1/s1
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n/an/an/an/a 2n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF method


Bioorg Med Chem Lett 24: 5478-83 (2015)


Article DOI: 10.1016/j.bmcl.2014.10.010
BindingDB Entry DOI: 10.7270/Q29C7019
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50036667
PNG
(CHEMBL3354798)
Show SMILES COC(=O)[C@@]1(Cc2cccc(F)c2)NCc2cnc3c(c(CO)nn3c12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H20F4N4O3/c1-36-23(35)24(10-14-3-2-4-18(26)9-14)21-16(12-31-24)11-30-22-20(19(13-34)32-33(21)22)15-5-7-17(8-6-15)25(27,28)29/h2-9,11,31,34H,10,12-13H2,1H3/t24-/m0/s1
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n/an/an/an/a 2n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF method


Bioorg Med Chem Lett 24: 5478-83 (2015)


Article DOI: 10.1016/j.bmcl.2014.10.010
BindingDB Entry DOI: 10.7270/Q29C7019
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50036664
PNG
(CHEMBL3354795)
Show SMILES COCCN(C)C(=O)[C@@]1(Cc2cccc(F)c2)NCc2cnc3c(cnn3c12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C27H25F4N5O2/c1-35(10-11-38-2)25(37)26(13-17-4-3-5-21(28)12-17)23-19(15-33-26)14-32-24-22(16-34-36(23)24)18-6-8-20(9-7-18)27(29,30)31/h3-9,12,14,16,33H,10-11,13,15H2,1-2H3/t26-/m0/s1
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n/an/an/an/a 2n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF method


Bioorg Med Chem Lett 24: 5478-83 (2015)


Article DOI: 10.1016/j.bmcl.2014.10.010
BindingDB Entry DOI: 10.7270/Q29C7019
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50036642
PNG
(CHEMBL3354779)
Show SMILES COC(=O)C1(Cc2ccccc2)CCc2cnc3c(cnn3c12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H20F3N3O2/c1-33-23(32)24(13-16-5-3-2-4-6-16)12-11-18-14-29-22-20(15-30-31(22)21(18)24)17-7-9-19(10-8-17)25(26,27)28/h2-10,14-15H,11-13H2,1H3
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n/an/an/an/a 2n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF method


Bioorg Med Chem Lett 24: 5478-83 (2015)


Article DOI: 10.1016/j.bmcl.2014.10.010
BindingDB Entry DOI: 10.7270/Q29C7019
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014384
PNG
(CHEMBL3261136)
Show SMILES CCCc1cnc(nc1)N1CCC(CC1)C1Cc2c(O1)c(F)cc(C1=CCN(CC1)S(=O)(=O)CCC)c2F
Show InChI InChI=1S/C28H36F2N4O3S/c1-3-5-19-17-31-28(32-18-19)33-10-6-21(7-11-33)25-16-23-26(30)22(15-24(29)27(23)37-25)20-8-12-34(13-9-20)38(35,36)14-4-2/h8,15,17-18,21,25H,3-7,9-14,16H2,1-2H3
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n/an/an/an/a 2n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342692
PNG
(4-(1'-(5-chloropyrimidin-2-yl)-4,4'-bipiperidin-1-...)
Show SMILES Cc1cc(nc(n1)C#N)N1CCC(CC1)C1CCN(CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H24ClN7/c1-14-10-19(26-18(11-22)25-14)27-6-2-15(3-7-27)16-4-8-28(9-5-16)20-23-12-17(21)13-24-20/h10,12-13,15-16H,2-9H2,1H3
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n/an/an/an/a 2n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342681
PNG
(CHEMBL1771082 | tert-butyl 1'-(6-cyano-2-methylpyr...)
Show SMILES Cc1nc(cc(n1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C)C#N
Show InChI InChI=1S/C21H31N5O2/c1-15-23-18(14-22)13-19(24-15)25-9-5-16(6-10-25)17-7-11-26(12-8-17)20(27)28-21(2,3)4/h13,16-17H,5-12H2,1-4H3
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342701
PNG
(2-(4-((1R,2S)-2-(2-(5-(1H-1,2,3-triazol-1-yl)pyrid...)
Show SMILES Clc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1CCOc1ccc(cn1)-n1ccnn1
Show InChI InChI=1S/C21H24ClN7O/c22-17-12-24-21(25-13-17)28-7-3-15(4-8-28)19-11-16(19)5-10-30-20-2-1-18(14-23-20)29-9-6-26-27-29/h1-2,6,9,12-16,19H,3-5,7-8,10-11H2/t16-,19-/m1/s1
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342702
PNG
(6-methyl-2-(2-((1S,2R)-2-(1-(5-methylpyrimidin-2-y...)
Show SMILES Cc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1CCOc1nc(C)cc(n1)C#N
Show InChI InChI=1S/C21H26N6O/c1-14-12-23-20(24-13-14)27-6-3-16(4-7-27)19-10-17(19)5-8-28-21-25-15(2)9-18(11-22)26-21/h9,12-13,16-17,19H,3-8,10H2,1-2H3/t17-,19-/m1/s1
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342680
PNG
(CHEMBL1771081 | tert-butyl 1'-(2-cyano-6-methylpyr...)
Show SMILES Cc1cc(nc(n1)C#N)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C21H31N5O2/c1-15-13-19(24-18(14-22)23-15)25-9-5-16(6-10-25)17-7-11-26(12-8-17)20(27)28-21(2,3)4/h13,16-17H,5-12H2,1-4H3
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342681
PNG
(CHEMBL1771082 | tert-butyl 1'-(6-cyano-2-methylpyr...)
Show SMILES Cc1nc(cc(n1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C)C#N
Show InChI InChI=1S/C21H31N5O2/c1-15-23-18(14-22)13-19(24-15)25-9-5-16(6-10-25)17-7-11-26(12-8-17)20(27)28-21(2,3)4/h13,16-17H,5-12H2,1-4H3
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
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