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Compile Data Set for Download or QSAR

Found 3858 hits Enz. Inhib. hit(s) with Target = 'Glutamate [NMDA] receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM50203305
PNG
(CHEMBL219060 | benzyl 4-[(pyridin-4-ylamino)methyl...)
Show SMILES O=C(OCc1ccccc1)N1CCC(CNc2ccncc2)CC1
Show InChI InChI=1S/C19H23N3O2/c23-19(24-15-17-4-2-1-3-5-17)22-12-8-16(9-13-22)14-21-18-6-10-20-11-7-18/h1-7,10-11,16H,8-9,12-15H2,(H,20,21)
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n/an/an/an/a 1.60n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human NR2B expressed in Ltk- cells by calcium flux assay


J Med Chem 50: 807-19 (2007)


Article DOI: 10.1021/jm060983w
BindingDB Entry DOI: 10.7270/Q2FX7944
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens)
BDBM50203311
PNG
(4-methylbenzyl 4-[(2-pyrimidinylamino)methyl]-1-pi...)
Show SMILES Cc1ccc(COC(=O)N2CCC(CNc3ncccn3)CC2)cc1
Show InChI InChI=1S/C19H24N4O2/c1-15-3-5-17(6-4-15)14-25-19(24)23-11-7-16(8-12-23)13-22-18-20-9-2-10-21-18/h2-6,9-10,16H,7-8,11-14H2,1H3,(H,20,21,22)
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n/an/an/an/a 5.60n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human NR2B expressed in Ltk- cells by calcium flux assay


J Med Chem 50: 807-19 (2007)


Article DOI: 10.1021/jm060983w
BindingDB Entry DOI: 10.7270/Q2FX7944
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164477
PNG
(CHEMBL3800556)
Show SMILES Cc1sc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n2c1[C@@H]1C[C@H]1CO
Show InChI InChI=1S/C16H14ClF3N4O2S/c1-7-14(10-2-8(10)6-25)24-13(26)3-9(21-15(24)27-7)5-23-12(17)4-11(22-23)16(18,19)20/h3-4,8,10,25H,2,5-6H2,1H3/t8-,10+/m0/s1
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n/an/an/an/a 18n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50205850
PNG
(CHEMBL3970291)
Show SMILES Fc1ccc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n2c1[C@@H]1C[C@H]1C#N
Show InChI InChI=1S/C17H10ClF4N5O/c18-13-5-12(17(20,21)22)25-26(13)7-9-4-15(28)27-14(24-9)2-1-11(19)16(27)10-3-8(10)6-23/h1-2,4-5,8,10H,3,7H2/t8-,10+/m0/s1
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n/an/an/an/a 21n/an/an/an/a



Genentech, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...


ACS Med Chem Lett 8: 84-89 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00388
BindingDB Entry DOI: 10.7270/Q2VX0JH1
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164398
PNG
(CHEMBL3799213)
Show SMILES FC(F)(F)c1cc(Cl)n(Cc2cc(=O)n3c([C@@H]4C[C@H]4C#N)c(sc3n2)C(F)(F)F)n1
Show InChI InChI=1S/C16H8ClF6N5OS/c17-10-3-9(15(18,19)20)26-27(10)5-7-2-11(29)28-12(8-1-6(8)4-24)13(16(21,22)23)30-14(28)25-7/h2-3,6,8H,1,5H2/t6-,8+/m0/s1
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n/an/an/an/a 21n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50205854
PNG
(CHEMBL3891918)
Show SMILES FC(F)(F)c1cc(Cl)n(Cc2cc(=O)n3c(cccc3n2)[C@@H]2C[C@H]2C#N)n1
Show InChI InChI=1S/C17H11ClF3N5O/c18-14-6-13(17(19,20)21)24-25(14)8-10-5-16(27)26-12(11-4-9(11)7-22)2-1-3-15(26)23-10/h1-3,5-6,9,11H,4,8H2/t9-,11+/m0/s1
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n/an/an/an/a 24n/an/an/an/a



Genentech, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...


ACS Med Chem Lett 8: 84-89 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00388
BindingDB Entry DOI: 10.7270/Q2VX0JH1
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164485
PNG
(CHEMBL3799657)
Show SMILES CCN(Cc1cc(=O)n2c([C@@H]3C[C@H]3CO)c(C)sc2n1)c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN3O2S/c1-3-23(16-6-4-14(21)5-7-16)10-15-9-18(26)24-19(17-8-13(17)11-25)12(2)27-20(24)22-15/h4-7,9,13,17,25H,3,8,10-11H2,1-2H3/t13-,17+/m0/s1
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n/an/an/an/a 24n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164380
PNG
(CHEMBL3799878)
Show SMILES Cc1sc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n2c1[C@@H]1C[C@H]1C#N
Show InChI InChI=1S/C16H11ClF3N5OS/c1-7-14(10-2-8(10)5-21)25-13(26)3-9(22-15(25)27-7)6-24-12(17)4-11(23-24)16(18,19)20/h3-4,8,10H,2,6H2,1H3/t8-,10+/m0/s1
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n/an/an/an/a 30n/an/an/an/a



Genentech, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...


ACS Med Chem Lett 8: 84-89 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00388
BindingDB Entry DOI: 10.7270/Q2VX0JH1
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164380
PNG
(CHEMBL3799878)
Show SMILES Cc1sc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n2c1[C@@H]1C[C@H]1C#N
Show InChI InChI=1S/C16H11ClF3N5OS/c1-7-14(10-2-8(10)5-21)25-13(26)3-9(22-15(25)27-7)6-24-12(17)4-11(23-24)16(18,19)20/h3-4,8,10H,2,6H2,1H3/t8-,10+/m0/s1
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n/an/an/an/a 30n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50205849
PNG
(CHEMBL3938522)
Show SMILES FC(F)(F)c1cc(Cl)n(Cc2cc(=O)n3c([C@@H]4C[C@H]4C#N)c(Cl)ccc3n2)n1
Show InChI InChI=1S/C17H10Cl2F3N5O/c18-11-1-2-14-24-9(7-26-13(19)5-12(25-26)17(20,21)22)4-15(28)27(14)16(11)10-3-8(10)6-23/h1-2,4-5,8,10H,3,7H2/t8-,10+/m0/s1
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n/an/an/an/a 37n/an/an/an/a



Genentech, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...


ACS Med Chem Lett 8: 84-89 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00388
BindingDB Entry DOI: 10.7270/Q2VX0JH1
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50205852
PNG
(CHEMBL3976578)
Show SMILES Cc1cc([C@@H]2C[C@H]2C#N)n2c(c1)nc(Cn1nc(cc1Cl)C(F)(F)F)cc2=O
Show InChI InChI=1S/C18H13ClF3N5O/c1-9-2-13(12-4-10(12)7-23)27-16(3-9)24-11(5-17(27)28)8-26-15(19)6-14(25-26)18(20,21)22/h2-3,5-6,10,12H,4,8H2,1H3/t10-,12+/m0/s1
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n/an/an/an/a 39n/an/an/an/a



Genentech, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...


ACS Med Chem Lett 8: 84-89 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00388
BindingDB Entry DOI: 10.7270/Q2VX0JH1
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50206009
PNG
(CHEMBL3983039)
Show SMILES Cc1ccc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n2c1[C@@H]1C[C@H]1C#N
Show InChI InChI=1S/C18H13ClF3N5O/c1-9-2-3-15-24-11(8-26-14(19)6-13(25-26)18(20,21)22)5-16(28)27(15)17(9)12-4-10(12)7-23/h2-3,5-6,10,12H,4,8H2,1H3/t10-,12+/m0/s1
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n/an/an/an/a 41n/an/an/an/a



Genentech, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...


ACS Med Chem Lett 8: 84-89 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00388
BindingDB Entry DOI: 10.7270/Q2VX0JH1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate [NMDA] receptor subunit epsilon 2/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50432711
PNG
(CHEMBL2348224)
Show SMILES C[C@@]1(C[C@H]1[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c1-7(6(11)12)2-3(7)4(8)5(9)10/h3-4H,2,8H2,1H3,(H,9,10)(H,11,12)/t3-,4-,7-/m0/s1
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n/an/an/an/a 45n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant wild type GluN1/GluN2B receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique


J Med Chem 56: 4071-81 (2013)


Article DOI: 10.1021/jm400346a
BindingDB Entry DOI: 10.7270/Q20G3MHR
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164484
PNG
(CHEMBL3797659)
Show SMILES CCN(Cc1cc(=O)n2c(C(C)=C)c(C)sc2n1)c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN3OS/c1-5-22(16-8-6-14(20)7-9-16)11-15-10-17(24)23-18(12(2)3)13(4)25-19(23)21-15/h6-10H,2,5,11H2,1,3-4H3
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n/an/an/an/a 60n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164386
PNG
(CHEMBL3797378)
Show SMILES CCN(Cc1cc(=O)n2c(c(C)sc2n1)C(C)(C)O)c1ccc(F)cc1
Show InChI InChI=1S/C19H22FN3O2S/c1-5-22(15-8-6-13(20)7-9-15)11-14-10-16(24)23-17(19(3,4)25)12(2)26-18(23)21-14/h6-10,25H,5,11H2,1-4H3
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n/an/an/an/a 63n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164460
PNG
(CHEMBL3799437)
Show SMILES OC[C@@H]1C[C@H]1c1c(sc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n12)C(F)(F)F
Show InChI InChI=1S/C16H11ClF6N4O2S/c17-10-3-9(15(18,19)20)25-26(10)4-7-2-11(29)27-12(8-1-6(8)5-28)13(16(21,22)23)30-14(27)24-7/h2-3,6,8,28H,1,4-5H2/t6-,8+/m0/s1
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n/an/an/an/a 73n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50205853
PNG
(CHEMBL3968067)
Show SMILES COc1ccc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n2c1[C@@H]1C[C@H]1C#N
Show InChI InChI=1S/C18H13ClF3N5O2/c1-29-12-2-3-15-24-10(8-26-14(19)6-13(25-26)18(20,21)22)5-16(28)27(15)17(12)11-4-9(11)7-23/h2-3,5-6,9,11H,4,8H2,1H3/t9-,11+/m0/s1
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n/an/an/an/a 80n/an/an/an/a



Genentech, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...


ACS Med Chem Lett 8: 84-89 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00388
BindingDB Entry DOI: 10.7270/Q2VX0JH1
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 2/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50220152
PNG
((1S,2R)-2-((S)-Amino-carboxy-methyl)-cyclopropanec...)
Show SMILES N[C@@H]([C@@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3+,4+/m1/s1
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n/an/an/an/a 83n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant wild type GluN1/GluN2B receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique


J Med Chem 56: 4071-81 (2013)


Article DOI: 10.1021/jm400346a
BindingDB Entry DOI: 10.7270/Q20G3MHR
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164483
PNG
(CHEMBL3798757)
Show SMILES CCN(Cc1cc(=O)n2c(C(C)=O)c(C)sc2n1)c1ccc(F)cc1
Show InChI InChI=1S/C18H18FN3O2S/c1-4-21(15-7-5-13(19)6-8-15)10-14-9-16(24)22-17(11(2)23)12(3)25-18(22)20-14/h5-9H,4,10H2,1-3H3
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n/an/an/an/a 88n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164446
PNG
(CHEMBL3798502)
Show SMILES CCNC(=O)c1c(C)sc2nc(CN(CC)c3ccc(F)cc3)cc(=O)n12
Show InChI InChI=1S/C19H21FN4O2S/c1-4-21-18(26)17-12(3)27-19-22-14(10-16(25)24(17)19)11-23(5-2)15-8-6-13(20)7-9-15/h6-10H,4-5,11H2,1-3H3,(H,21,26)
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n/an/an/an/a 93n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50220152
PNG
((1S,2R)-2-((S)-Amino-carboxy-methyl)-cyclopropanec...)
Show SMILES N[C@@H]([C@@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3+,4+/m1/s1
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n/an/an/an/a 110n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant wild type GluN1/GluN2C receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique


J Med Chem 56: 4071-81 (2013)


Article DOI: 10.1021/jm400346a
BindingDB Entry DOI: 10.7270/Q20G3MHR
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50205848
PNG
(CHEMBL3948381)
Show SMILES FC(F)(F)c1cc(Cl)n(Cc2cc(=O)n3c(cc(cc3n2)C(F)(F)F)[C@@H]2C[C@H]2C#N)n1
Show InChI InChI=1S/C18H10ClF6N5O/c19-14-5-13(18(23,24)25)28-29(14)7-10-4-16(31)30-12(11-1-8(11)6-26)2-9(17(20,21)22)3-15(30)27-10/h2-5,8,11H,1,7H2/t8-,11+/m0/s1
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n/an/an/an/a 120n/an/an/an/a



Genentech, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...


ACS Med Chem Lett 8: 84-89 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00388
BindingDB Entry DOI: 10.7270/Q2VX0JH1
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50432711
PNG
(CHEMBL2348224)
Show SMILES C[C@@]1(C[C@H]1[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c1-7(6(11)12)2-3(7)4(8)5(9)10/h3-4H,2,8H2,1H3,(H,9,10)(H,11,12)/t3-,4-,7-/m0/s1
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n/an/an/an/a 124n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant wild type GluN1/GluN2C receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique


J Med Chem 56: 4071-81 (2013)


Article DOI: 10.1021/jm400346a
BindingDB Entry DOI: 10.7270/Q20G3MHR
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164396
PNG
(CHEMBL3799103)
Show SMILES CCN(Cc1cc(=O)n2c(C#N)c(C)sc2n1)c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN4OS/c1-3-21(14-6-4-12(18)5-7-14)10-13-8-16(23)22-15(9-19)11(2)24-17(22)20-13/h4-8H,3,10H2,1-2H3
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n/an/an/an/a 129n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50205896
PNG
(CHEMBL3944810)
Show SMILES COc1cc([C@@H]2C[C@H]2C#N)n2c(c1)nc(Cn1nc(cc1Cl)C(F)(F)F)cc2=O
Show InChI InChI=1S/C18H13ClF3N5O2/c1-29-11-4-13(12-2-9(12)7-23)27-16(5-11)24-10(3-17(27)28)8-26-15(19)6-14(25-26)18(20,21)22/h3-6,9,12H,2,8H2,1H3/t9-,12+/m0/s1
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n/an/an/an/a 130n/an/an/an/a



Genentech, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...


ACS Med Chem Lett 8: 84-89 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00388
BindingDB Entry DOI: 10.7270/Q2VX0JH1
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164452
PNG
(CHEMBL3800614)
Show SMILES CCN(Cc1cc(=O)n2c(C(=O)NC)c(C)sc2n1)c1ccc(F)cc1
Show InChI InChI=1S/C18H19FN4O2S/c1-4-22(14-7-5-12(19)6-8-14)10-13-9-15(24)23-16(17(25)20-3)11(2)26-18(23)21-13/h5-9H,4,10H2,1-3H3,(H,20,25)
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n/an/an/an/a 131n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164478
PNG
(CHEMBL3798041)
Show SMILES CCCN(Cc1cc(=O)n2c(C(=O)NCC)c(C)sc2n1)c1ccc(F)cc1
Show InChI InChI=1S/C20H23FN4O2S/c1-4-10-24(16-8-6-14(21)7-9-16)12-15-11-17(26)25-18(19(27)22-5-2)13(3)28-20(25)23-15/h6-9,11H,4-5,10,12H2,1-3H3,(H,22,27)
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Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164394
PNG
(CHEMBL3800085)
Show SMILES CCN(Cc1cc(=O)n2c(c(C)sc2n1)-c1cncnc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H18FN5OS/c1-3-25(17-6-4-15(21)5-7-17)11-16-8-18(27)26-19(13(2)28-20(26)24-16)14-9-22-12-23-10-14/h4-10,12H,3,11H2,1-2H3
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n/an/an/an/a 137n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164401
PNG
(CHEMBL3797925)
Show SMILES CCN(Cc1cc(=O)n2c(CCO)c(C)sc2n1)c1ccc(F)cc1
Show InChI InChI=1S/C18H20FN3O2S/c1-3-21(15-6-4-13(19)5-7-15)11-14-10-17(24)22-16(8-9-23)12(2)25-18(22)20-14/h4-7,10,23H,3,8-9,11H2,1-2H3
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n/an/an/an/a 159n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164395
PNG
(CHEMBL3799697)
Show SMILES CCN(Cc1cc(=O)n2c(c(C)sc2n1)-c1cccnc1)c1ccc(F)cc1
Show InChI InChI=1S/C21H19FN4OS/c1-3-25(18-8-6-16(22)7-9-18)13-17-11-19(27)26-20(14(2)28-21(26)24-17)15-5-4-10-23-12-15/h4-12H,3,13H2,1-2H3
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n/an/an/an/a 168n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164399
PNG
(CHEMBL3797313)
Show SMILES CCN(Cc1cc(=O)n2c(CCCO)c(C)sc2n1)c1ccc(F)cc1
Show InChI InChI=1S/C19H22FN3O2S/c1-3-22(16-8-6-14(20)7-9-16)12-15-11-18(25)23-17(5-4-10-24)13(2)26-19(23)21-15/h6-9,11,24H,3-5,10,12H2,1-2H3
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n/an/an/an/a 183n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164388
PNG
(CHEMBL3799832)
Show SMILES CCN(Cc1cc(=O)n2c(C(C)O)c(C)sc2n1)c1ccc(F)cc1
Show InChI InChI=1S/C18H20FN3O2S/c1-4-21(15-7-5-13(19)6-8-15)10-14-9-16(24)22-17(11(2)23)12(3)25-18(22)20-14/h5-9,11,23H,4,10H2,1-3H3
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n/an/an/an/a 183n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50220152
PNG
((1S,2R)-2-((S)-Amino-carboxy-methyl)-cyclopropanec...)
Show SMILES N[C@@H]([C@@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3+,4+/m1/s1
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n/an/an/an/a 262n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant wild type GluN1/GluN2A receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique


J Med Chem 56: 4071-81 (2013)


Article DOI: 10.1021/jm400346a
BindingDB Entry DOI: 10.7270/Q20G3MHR
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50206010
PNG
(CHEMBL3945685)
Show SMILES Cc1sc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n2c1C1CC1
Show InChI InChI=1S/C15H12ClF3N4OS/c1-7-13(8-2-3-8)23-12(24)4-9(20-14(23)25-7)6-22-11(16)5-10(21-22)15(17,18)19/h4-5,8H,2-3,6H2,1H3
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n/an/an/an/a 270n/an/an/an/a



Genentech, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...


ACS Med Chem Lett 8: 84-89 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00388
BindingDB Entry DOI: 10.7270/Q2VX0JH1
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 2/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50432710
PNG
(CHEMBL2348221)
Show SMILES CC[C@@]1(C[C@H]1[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H13NO4/c1-2-8(7(12)13)3-4(8)5(9)6(10)11/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t4-,5-,8-/m0/s1
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University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant wild type GluN1/GluN2B receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique


J Med Chem 56: 4071-81 (2013)


Article DOI: 10.1021/jm400346a
BindingDB Entry DOI: 10.7270/Q20G3MHR
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50432711
PNG
(CHEMBL2348224)
Show SMILES C[C@@]1(C[C@H]1[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c1-7(6(11)12)2-3(7)4(8)5(9)10/h3-4H,2,8H2,1H3,(H,9,10)(H,11,12)/t3-,4-,7-/m0/s1
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n/an/an/an/a 277n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant wild type GluN1/GluN2A receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique


J Med Chem 56: 4071-81 (2013)


Article DOI: 10.1021/jm400346a
BindingDB Entry DOI: 10.7270/Q20G3MHR
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50205855
PNG
(CHEMBL3975050)
Show SMILES Cc1ccc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n2c1C1CC1
Show InChI InChI=1S/C17H14ClF3N4O/c1-9-2-5-14-22-11(6-15(26)25(14)16(9)10-3-4-10)8-24-13(18)7-12(23-24)17(19,20)21/h2,5-7,10H,3-4,8H2,1H3
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Genentech, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...


ACS Med Chem Lett 8: 84-89 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00388
BindingDB Entry DOI: 10.7270/Q2VX0JH1
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436093
PNG
(CHEMBL2397268)
Show SMILES COc1ccc(OCC2N(CCc3cc(OCc4ccccc4)ccc23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C31H28BrNO4/c1-35-26-10-12-27(13-11-26)37-21-30-29-15-14-28(36-20-22-6-3-2-4-7-22)19-23(29)16-17-33(30)31(34)24-8-5-9-25(32)18-24/h2-15,18-19,30H,16-17,20-21H2,1H3
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n/an/an/an/a 300n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50078513
PNG
(7,8-Dichloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5...)
Show SMILES OC(=O)c1nc2n(n1)c1cc(Cl)c(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C10H4Cl2N4O3/c11-3-1-5-6(2-4(3)12)16-8(9(17)13-5)14-7(15-16)10(18)19/h1-2H,(H,13,17)(H,18,19)
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Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the NMDA receptor-ion channel complex was demonstrated by the ability to inhibit the binding of thechannel-blocking agent [3...


J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164476
PNG
(CHEMBL3799732)
Show SMILES CCN(Cc1cc(=O)n2cc(C)sc2n1)c1ccc(F)cc1
Show InChI InChI=1S/C16H16FN3OS/c1-3-19(14-6-4-12(17)5-7-14)10-13-8-15(21)20-9-11(2)22-16(20)18-13/h4-9H,3,10H2,1-2H3
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n/an/an/an/a 312n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50001266
PNG
(5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...)
Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1
Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
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n/an/an/an/a 330n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...


J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164482
PNG
(CHEMBL3800265)
Show SMILES Cc1sc2nc(COc3ccc(F)cc3)cc(=O)n2c1[C@@H]1C[C@H]1CO
Show InChI InChI=1S/C18H17FN2O3S/c1-10-17(15-6-11(15)8-22)21-16(23)7-13(20-18(21)25-10)9-24-14-4-2-12(19)3-5-14/h2-5,7,11,15,22H,6,8-9H2,1H3/t11-,15+/m0/s1
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n/an/an/an/a 382n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164479
PNG
(CHEMBL3799325)
Show SMILES CCN(Cc1cc(=O)n2c(C3CC3)c(C)sc2n1)c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN3OS/c1-3-22(16-8-6-14(20)7-9-16)11-15-10-17(24)23-18(13-4-5-13)12(2)25-19(23)21-15/h6-10,13H,3-5,11H2,1-2H3
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n/an/an/an/a 394n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436094
PNG
(CHEMBL2397267)
Show SMILES COc1ccc(OCC2N(CCc3cc(OCc4ccccc4)ccc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C31H28ClNO4/c1-35-26-10-12-27(13-11-26)37-21-30-29-15-14-28(36-20-22-6-3-2-4-7-22)19-23(29)16-17-33(30)31(34)24-8-5-9-25(32)18-24/h2-15,18-19,30H,16-17,20-21H2,1H3
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n/an/an/an/a 400n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164481
PNG
(CHEMBL3799759)
Show SMILES CCNC(=O)c1c(C)sc2nc(Cn3nc(cc3OCC)C(F)(F)F)cc(=O)n12
Show InChI InChI=1S/C17H18F3N5O3S/c1-4-21-15(27)14-9(3)29-16-22-10(6-12(26)25(14)16)8-24-13(28-5-2)7-11(23-24)17(18,19)20/h6-7H,4-5,8H2,1-3H3,(H,21,27)
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Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164475
PNG
(CHEMBL3800406)
Show SMILES CCNC(=O)c1c(C)sc2nc(CN(C)c3ccc(F)cc3)cc(=O)n12
Show InChI InChI=1S/C18H19FN4O2S/c1-4-20-17(25)16-11(2)26-18-21-13(9-15(24)23(16)18)10-22(3)14-7-5-12(19)6-8-14/h5-9H,4,10H2,1-3H3,(H,20,25)
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Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164400
PNG
(CHEMBL3799694)
Show SMILES CCNC(=O)c1c(C)sc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n12
Show InChI InChI=1S/C15H13ClF3N5O2S/c1-3-20-13(26)12-7(2)27-14-21-8(4-11(25)24(12)14)6-23-10(16)5-9(22-23)15(17,18)19/h4-5H,3,6H2,1-2H3,(H,20,26)
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n/an/an/an/a 436n/an/an/an/a



Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164400
PNG
(CHEMBL3799694)
Show SMILES CCNC(=O)c1c(C)sc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n12
Show InChI InChI=1S/C15H13ClF3N5O2S/c1-3-20-13(26)12-7(2)27-14-21-8(4-11(25)24(12)14)6-23-10(16)5-9(22-23)15(17,18)19/h4-5H,3,6H2,1-2H3,(H,20,26)
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n/an/an/an/a 440n/an/an/an/a



Genentech, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...


ACS Med Chem Lett 8: 84-89 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00388
BindingDB Entry DOI: 10.7270/Q2VX0JH1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate-NMDA


(RAT)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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n/an/an/an/a 450n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at rat NR1/NR2D receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology


J Med Chem 51: 4179-87 (2008)


Article DOI: 10.1021/jm800025e
BindingDB Entry DOI: 10.7270/Q28C9X5Q
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Homo sapiens)
BDBM50164444
PNG
(CHEMBL3800605)
Show SMILES Cc1sc2nc(Cc3cccc(c3F)C(F)(F)F)cc(=O)n2c1C1CC1CO
Show InChI InChI=1S/C19H16F4N2O2S/c1-9-17(13-6-11(13)8-26)25-15(27)7-12(24-18(25)28-9)5-10-3-2-4-14(16(10)20)19(21,22)23/h2-4,7,11,13,26H,5-6,8H2,1H3
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Pharmaron-Beijing Co. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...


J Med Chem 59: 2760-79 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02010
BindingDB Entry DOI: 10.7270/Q2N87CQW
More data for this
Ligand-Target Pair
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