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Compile Data Set for Download or QSAR

Found 346 hits Enz. Inhib. hit(s) with Target = 'Glutamate [NMDA] receptor subunit epsilon 3/zeta 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50220152
PNG
((1S,2R)-2-((S)-Amino-carboxy-methyl)-cyclopropanec...)
Show SMILES N[C@@H]([C@@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3+,4+/m1/s1
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n/an/an/an/a 110n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant wild type GluN1/GluN2C receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique


J Med Chem 56: 4071-81 (2013)


Article DOI: 10.1021/jm400346a
BindingDB Entry DOI: 10.7270/Q20G3MHR
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50432711
PNG
(CHEMBL2348224)
Show SMILES C[C@@]1(C[C@H]1[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c1-7(6(11)12)2-3(7)4(8)5(9)10/h3-4H,2,8H2,1H3,(H,9,10)(H,11,12)/t3-,4-,7-/m0/s1
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n/an/an/an/a 124n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant wild type GluN1/GluN2C receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique


J Med Chem 56: 4071-81 (2013)


Article DOI: 10.1021/jm400346a
BindingDB Entry DOI: 10.7270/Q20G3MHR
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436093
PNG
(CHEMBL2397268)
Show SMILES COc1ccc(OCC2N(CCc3cc(OCc4ccccc4)ccc23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C31H28BrNO4/c1-35-26-10-12-27(13-11-26)37-21-30-29-15-14-28(36-20-22-6-3-2-4-7-22)19-23(29)16-17-33(30)31(34)24-8-5-9-25(32)18-24/h2-15,18-19,30H,16-17,20-21H2,1H3
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n/an/an/an/a 300n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436094
PNG
(CHEMBL2397267)
Show SMILES COc1ccc(OCC2N(CCc3cc(OCc4ccccc4)ccc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C31H28ClNO4/c1-35-26-10-12-27(13-11-26)37-21-30-29-15-14-28(36-20-22-6-3-2-4-7-22)19-23(29)16-17-33(30)31(34)24-8-5-9-25(32)18-24/h2-15,18-19,30H,16-17,20-21H2,1H3
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n/an/an/an/a 400n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50432710
PNG
(CHEMBL2348221)
Show SMILES CC[C@@]1(C[C@H]1[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H13NO4/c1-2-8(7(12)13)3-4(8)5(9)6(10)11/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t4-,5-,8-/m0/s1
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n/an/an/an/a 540n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant wild type GluN1/GluN2C receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique


J Med Chem 56: 4071-81 (2013)


Article DOI: 10.1021/jm400346a
BindingDB Entry DOI: 10.7270/Q20G3MHR
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436095
PNG
(CHEMBL2397266)
Show SMILES COc1ccc(OCC2N(CCc3cc(OCc4ccccc4)ccc23)C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C31H29NO4/c1-34-26-12-14-27(15-13-26)36-22-30-29-17-16-28(35-21-23-8-4-2-5-9-23)20-25(29)18-19-32(30)31(33)24-10-6-3-7-11-24/h2-17,20,30H,18-19,21-22H2,1H3
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n/an/an/an/a 700n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436082
PNG
(CHEMBL2397103)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C26H26BrNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/an/an/a 900n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436098
PNG
(CHEMBL2397262)
Show SMILES COc1ccc(OCC2N(CCc3cc(C)c(C)cc23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C26H26BrNO3/c1-17-13-19-11-12-28(26(29)20-5-4-6-21(27)15-20)25(24(19)14-18(17)2)16-31-23-9-7-22(30-3)8-10-23/h4-10,13-15,25H,11-12,16H2,1-3H3
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n/an/an/an/a 900n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436088
PNG
(CHEMBL2397121)
Show SMILES COc1ccc(\C=C\C2N(CCc3cc(OC)ccc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C26H24ClNO3/c1-30-22-9-6-18(7-10-22)8-13-25-24-12-11-23(31-2)17-19(24)14-15-28(25)26(29)20-4-3-5-21(27)16-20/h3-13,16-17,25H,14-15H2,1-2H3/b13-8+
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n/an/an/an/a 1.00E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436090
PNG
(CHEMBL2397119)
Show SMILES COc1ccc(\C=C\C2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C27H26ClNO4/c1-31-22-10-7-18(8-11-22)9-12-24-23-17-26(33-3)25(32-2)16-19(23)13-14-29(24)27(30)20-5-4-6-21(28)15-20/h4-12,15-17,24H,13-14H2,1-3H3/b12-9+
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n/an/an/an/a 1.10E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436102
PNG
(CHEMBL2397256)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)ccc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C25H24ClNO4/c1-29-20-6-8-21(9-7-20)31-16-24-23-11-10-22(30-2)15-17(23)12-13-27(24)25(28)18-4-3-5-19(26)14-18/h3-11,14-15,24H,12-13,16H2,1-2H3
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n/an/an/an/a 1.30E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436099
PNG
(CHEMBL2397261)
Show SMILES COc1ccc(OCC2N(CCc3cc(C)c(C)cc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C26H26ClNO3/c1-17-13-19-11-12-28(26(29)20-5-4-6-21(27)15-20)25(24(19)14-18(17)2)16-31-23-9-7-22(30-3)8-10-23/h4-10,13-15,25H,11-12,16H2,1-3H3
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n/an/an/an/a 1.40E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436078
PNG
(CHEMBL2397109)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Cl)c2Cl)cc1
Show InChI InChI=1S/C26H25Cl2NO5/c1-31-17-7-9-18(10-8-17)34-15-22-20-14-24(33-3)23(32-2)13-16(20)11-12-29(22)26(30)19-5-4-6-21(27)25(19)28/h4-10,13-14,22H,11-12,15H2,1-3H3
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n/an/an/an/a 1.40E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436087
PNG
(CHEMBL2397274)
Show SMILES COc1ccc(\C=C\C2N(CCc3cc(OC)ccc23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C26H24BrNO3/c1-30-22-9-6-18(7-10-22)8-13-25-24-12-11-23(31-2)17-19(24)14-15-28(25)26(29)20-4-3-5-21(27)16-20/h3-13,16-17,25H,14-15H2,1-2H3/b13-8+
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n/an/an/an/a 1.50E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436101
PNG
(CHEMBL2397257)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)ccc23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C25H24BrNO4/c1-29-20-6-8-21(9-7-20)31-16-24-23-11-10-22(30-2)15-17(23)12-13-27(24)25(28)18-4-3-5-19(26)14-18/h3-11,14-15,24H,12-13,16H2,1-2H3
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n/an/an/an/a 2.00E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436072
PNG
(CHEMBL2397211)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H26F3NO5/c1-33-20-7-9-21(10-8-20)36-16-23-22-15-25(35-3)24(34-2)14-17(22)11-12-31(23)26(32)18-5-4-6-19(13-18)27(28,29)30/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/an/an/a 2.40E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436089
PNG
(CHEMBL2397120)
Show SMILES COc1ccc(\C=C\C2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C27H26BrNO4/c1-31-22-10-7-18(8-11-22)9-12-24-23-17-26(33-3)25(32-2)16-19(23)13-14-29(24)27(30)20-5-4-6-21(28)15-20/h4-12,15-17,24H,13-14H2,1-3H3/b12-9+
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n/an/an/an/a 2.80E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436073
PNG
(CHEMBL2397210)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(c2)-c2ccccc2)cc1
Show InChI InChI=1S/C32H31NO5/c1-35-26-12-14-27(15-13-26)38-21-29-28-20-31(37-3)30(36-2)19-24(28)16-17-33(29)32(34)25-11-7-10-23(18-25)22-8-5-4-6-9-22/h4-15,18-20,29H,16-17,21H2,1-3H3
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n/an/an/an/a 2.90E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436096
PNG
(CHEMBL2397265)
Show SMILES COc1ccc(OCC2N(CCc3cc(C)ccc23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C25H24BrNO3/c1-17-6-11-23-18(14-17)12-13-27(25(28)19-4-3-5-20(26)15-19)24(23)16-30-22-9-7-21(29-2)8-10-22/h3-11,14-15,24H,12-13,16H2,1-2H3
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n/an/an/an/a 3.20E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436063
PNG
(CHEMBL2397251)
Show SMILES COc1ccc(OCC2N(CCc3cc4OCOc4cc23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C25H22BrNO5/c1-29-19-5-7-20(8-6-19)30-14-22-21-13-24-23(31-15-32-24)12-16(21)9-10-27(22)25(28)17-3-2-4-18(26)11-17/h2-8,11-13,22H,9-10,14-15H2,1H3
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n/an/an/an/a 3.20E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436071
PNG
(CHEMBL2397214)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(c2)C(Cl)Cl)cc1
Show InChI InChI=1S/C27H27Cl2NO5/c1-32-20-7-9-21(10-8-20)35-16-23-22-15-25(34-3)24(33-2)14-17(22)11-12-30(23)27(31)19-6-4-5-18(13-19)26(28)29/h4-10,13-15,23,26H,11-12,16H2,1-3H3
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n/an/an/an/a 3.70E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436074
PNG
(CHEMBL2397209)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(I)c2)cc1
Show InChI InChI=1S/C26H26INO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/an/an/a 4.00E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436060
PNG
(CHEMBL2397100)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/an/an/a 4.10E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436061
PNG
(CHEMBL2397099)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C26H26ClNO5/c1-30-20-8-10-21(11-9-20)33-16-23-22-15-25(32-3)24(31-2)14-18(22)12-13-28(23)26(29)17-4-6-19(27)7-5-17/h4-11,14-15,23H,12-13,16H2,1-3H3
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n/an/an/an/a 4.10E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50007010
PNG
(CHEMBL3237286)
Show SMILES COC(=O)c1ccc(cc1)C1N(CCc2c[nH]c3cc(C)ccc23)C(=O)C(O)=C1C(=O)c1cccnc1
Show InChI InChI=1S/C29H25N3O5/c1-17-5-10-22-20(16-31-23(22)14-17)11-13-32-25(18-6-8-19(9-7-18)29(36)37-2)24(27(34)28(32)35)26(33)21-4-3-12-30-15-21/h3-10,12,14-16,25,31,34H,11,13H2,1-2H3
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n/an/an/an/a 4.30E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Potentiation of rat recombinant GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response b...


J Med Chem 57: 2334-56 (2014)


Article DOI: 10.1021/jm401695d
BindingDB Entry DOI: 10.7270/Q2SB4786
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436077
PNG
(CHEMBL2397123)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cc(Cl)cc(Cl)c2)cc1
Show InChI InChI=1S/C26H25Cl2NO5/c1-31-20-4-6-21(7-5-20)34-15-23-22-14-25(33-3)24(32-2)12-16(22)8-9-29(23)26(30)17-10-18(27)13-19(28)11-17/h4-7,10-14,23H,8-9,15H2,1-3H3
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n/an/an/an/a 4.80E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436097
PNG
(CHEMBL2397264)
Show SMILES COc1ccc(OCC2N(CCc3cc(C)ccc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C25H24ClNO3/c1-17-6-11-23-18(14-17)12-13-27(25(28)19-4-3-5-20(26)15-19)24(23)16-30-22-9-7-21(29-2)8-10-22/h3-11,14-15,24H,12-13,16H2,1-2H3
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n/an/an/an/a 5.00E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436068
PNG
(CHEMBL2397232)
Show SMILES COc1cc2CCN(C(COc3ccc(SC)cc3)c2cc1OC)C(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C26H26ClNO4S/c1-30-24-14-17-11-12-28(26(29)18-5-4-6-19(27)13-18)23(22(17)15-25(24)31-2)16-32-20-7-9-21(33-3)10-8-20/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/an/an/a 5.10E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436092
PNG
(CHEMBL2397113)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=S)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C27H30N2O4S/c1-18-6-5-7-20(14-18)28-27(34)29-13-12-19-15-25(31-3)26(32-4)16-23(19)24(29)17-33-22-10-8-21(30-2)9-11-22/h5-11,14-16,24H,12-13,17H2,1-4H3,(H,28,34)
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n/an/an/an/a 5.20E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436076
PNG
(CHEMBL2397124)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2ccc(F)c(Cl)c2)cc1
Show InChI InChI=1S/C26H25ClFNO5/c1-31-18-5-7-19(8-6-18)34-15-23-20-14-25(33-3)24(32-2)13-16(20)10-11-29(23)26(30)17-4-9-22(28)21(27)12-17/h4-9,12-14,23H,10-11,15H2,1-3H3
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n/an/an/an/a 5.30E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436081
PNG
(CHEMBL2397105)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(OC)c2)cc1
Show InChI InChI=1S/C27H29NO6/c1-30-20-8-10-21(11-9-20)34-17-24-23-16-26(33-4)25(32-3)15-18(23)12-13-28(24)27(29)19-6-5-7-22(14-19)31-2/h5-11,14-16,24H,12-13,17H2,1-4H3
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n/an/an/an/a 5.80E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436105
PNG
(CHEMBL2397253)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)cc(OC)c23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-25-17(14-22(31-2)15-24(25)32-3)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/an/an/a 6.10E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436083
PNG
(CHEMBL2397097)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(C)c2)cc1
Show InChI InChI=1S/C27H29NO5/c1-18-6-5-7-20(14-18)27(29)28-13-12-19-15-25(31-3)26(32-4)16-23(19)24(28)17-33-22-10-8-21(30-2)9-11-22/h5-11,14-16,24H,12-13,17H2,1-4H3
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n/an/an/an/a 6.20E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50007013
PNG
(CHEMBL3237289)
Show SMILES COC(=O)c1ccc(cc1)C1N(CCc2c[nH]c3c(Cl)cccc23)C(=O)C(O)=C1C(=O)c1cccnc1
Show InChI InChI=1S/C28H22ClN3O5/c1-37-28(36)17-9-7-16(8-10-17)24-22(25(33)19-4-3-12-30-14-19)26(34)27(35)32(24)13-11-18-15-31-23-20(18)5-2-6-21(23)29/h2-10,12,14-15,24,31,34H,11,13H2,1H3
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n/an/an/an/a 7.00E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Potentiation of rat recombinant GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response b...


J Med Chem 57: 2334-56 (2014)


Article DOI: 10.1021/jm401695d
BindingDB Entry DOI: 10.7270/Q2SB4786
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50006939
PNG
(CHEMBL3237250)
Show SMILES COC(=O)c1ccc(cc1)C1N(CCc2c[nH]c3ccccc23)C(=O)C(O)=C1C(=O)c1cccc(O)c1
Show InChI InChI=1S/C29H24N2O6/c1-37-29(36)18-11-9-17(10-12-18)25-24(26(33)19-5-4-6-21(32)15-19)27(34)28(35)31(25)14-13-20-16-30-23-8-3-2-7-22(20)23/h2-12,15-16,25,30,32,34H,13-14H2,1H3
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n/an/an/an/a 7.00E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Potentiation of rat recombinant GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response b...


J Med Chem 57: 2334-56 (2014)


Article DOI: 10.1021/jm401695d
BindingDB Entry DOI: 10.7270/Q2SB4786
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436075
PNG
(CHEMBL2397208)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(F)c2)cc1
Show InChI InChI=1S/C26H26FNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/an/an/a 7.20E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436103
PNG
(CHEMBL2397255)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)ccc23)C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C25H25NO4/c1-28-20-8-10-21(11-9-20)30-17-24-23-13-12-22(29-2)16-19(23)14-15-26(24)25(27)18-6-4-3-5-7-18/h3-13,16,24H,14-15,17H2,1-2H3
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n/an/an/an/a 7.50E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50007011
PNG
(CHEMBL3237287)
Show SMILES COC(=O)c1ccc(cc1)C1N(CCc2c[nH]c3cc(OC)ccc23)C(=O)C(O)=C1C(=O)c1cccnc1
Show InChI InChI=1S/C29H25N3O6/c1-37-21-9-10-22-19(16-31-23(22)14-21)11-13-32-25(17-5-7-18(8-6-17)29(36)38-2)24(27(34)28(32)35)26(33)20-4-3-12-30-15-20/h3-10,12,14-16,25,31,34H,11,13H2,1-2H3
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n/an/an/an/a 8.00E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Potentiation of rat recombinant GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response b...


J Med Chem 57: 2334-56 (2014)


Article DOI: 10.1021/jm401695d
BindingDB Entry DOI: 10.7270/Q2SB4786
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50007015
PNG
(CHEMBL3237291)
Show SMILES CCOC(=O)c1ccc(cc1)C1N(CCc2c[nH]c3ccccc23)C(=O)C(O)=C1C(=O)c1cccnc1
Show InChI InChI=1S/C29H25N3O5/c1-2-37-29(36)19-11-9-18(10-12-19)25-24(26(33)21-6-5-14-30-16-21)27(34)28(35)32(25)15-13-20-17-31-23-8-4-3-7-22(20)23/h3-12,14,16-17,25,31,34H,2,13,15H2,1H3
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n/an/an/an/a 8.20E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Potentiation of rat recombinant GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response b...


J Med Chem 57: 2334-56 (2014)


Article DOI: 10.1021/jm401695d
BindingDB Entry DOI: 10.7270/Q2SB4786
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50007009
PNG
(CHEMBL3237285)
Show SMILES COC(=O)c1ccc(cc1)C1N(CCc2c[nH]c3cc(Cl)ccc23)C(=O)C(O)=C1C(=O)c1cccnc1
Show InChI InChI=1S/C28H22ClN3O5/c1-37-28(36)17-6-4-16(5-7-17)24-23(25(33)19-3-2-11-30-14-19)26(34)27(35)32(24)12-10-18-15-31-22-13-20(29)8-9-21(18)22/h2-9,11,13-15,24,31,34H,10,12H2,1H3
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n/an/an/an/a 8.50E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Potentiation of rat recombinant GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response b...


J Med Chem 57: 2334-56 (2014)


Article DOI: 10.1021/jm401695d
BindingDB Entry DOI: 10.7270/Q2SB4786
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50006941
PNG
(CHEMBL3237253)
Show SMILES COC(=O)c1ccc(cc1)C1N(CCc2c[nH]c3ccccc23)C(=O)C(O)=C1C(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C29H23ClN2O5/c1-37-29(36)18-11-9-17(10-12-18)25-24(26(33)19-5-4-6-21(30)15-19)27(34)28(35)32(25)14-13-20-16-31-23-8-3-2-7-22(20)23/h2-12,15-16,25,31,34H,13-14H2,1H3
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n/an/an/an/a 8.70E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Potentiation of rat recombinant GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response b...


J Med Chem 57: 2334-56 (2014)


Article DOI: 10.1021/jm401695d
BindingDB Entry DOI: 10.7270/Q2SB4786
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50006944
PNG
(CHEMBL3237257)
Show SMILES COC(=O)c1ccc(cc1)C1N(CCc2c[nH]c3ccccc23)C(=O)C(O)=C1C(=O)c1ccncc1
Show InChI InChI=1S/C28H23N3O5/c1-36-28(35)19-8-6-17(7-9-19)24-23(25(32)18-10-13-29-14-11-18)26(33)27(34)31(24)15-12-20-16-30-22-5-3-2-4-21(20)22/h2-11,13-14,16,24,30,33H,12,15H2,1H3
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n/an/an/an/a 8.90E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Potentiation of rat recombinant GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response b...


J Med Chem 57: 2334-56 (2014)


Article DOI: 10.1021/jm401695d
BindingDB Entry DOI: 10.7270/Q2SB4786
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436085
PNG
(CHEMBL2397093)
Show SMILES COc1ccc(OC[C@H]2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3/t23-/m1/s1
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n/an/an/an/a 9.00E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436069
PNG
(CHEMBL2397221)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccs2)cc1
Show InChI InChI=1S/C24H25NO5S/c1-27-17-6-8-18(9-7-17)30-15-20-19-14-22(29-3)21(28-2)13-16(19)10-11-25(20)24(26)23-5-4-12-31-23/h4-9,12-14,20H,10-11,15H2,1-3H3
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n/an/an/an/a 9.00E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436104
PNG
(CHEMBL2397254)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)cc(OC)c23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C26H26BrNO5/c1-30-20-7-9-21(10-8-20)33-16-23-25-17(14-22(31-2)15-24(25)32-3)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/an/an/a 9.00E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50007016
PNG
(CHEMBL3237292)
Show SMILES CCOC(=O)c1ccc(cc1)C1N(CCc2c[nH]c3ccccc23)C(=O)C(O)=C1C(=O)c1ccncc1
Show InChI InChI=1S/C29H25N3O5/c1-2-37-29(36)20-9-7-18(8-10-20)25-24(26(33)19-11-14-30-15-12-19)27(34)28(35)32(25)16-13-21-17-31-23-6-4-3-5-22(21)23/h3-12,14-15,17,25,31,34H,2,13,16H2,1H3
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n/an/an/an/a 9.70E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Potentiation of rat recombinant GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response b...


J Med Chem 57: 2334-56 (2014)


Article DOI: 10.1021/jm401695d
BindingDB Entry DOI: 10.7270/Q2SB4786
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436062
PNG
(CHEMBL2397252)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)cc(OC)c23)C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C26H27NO5/c1-29-20-9-11-21(12-10-20)32-17-23-25-19(15-22(30-2)16-24(25)31-3)13-14-27(23)26(28)18-7-5-4-6-8-18/h4-12,15-16,23H,13-14,17H2,1-3H3
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n/an/an/an/a 1.00E+4n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50006942
PNG
(CHEMBL3237254)
Show SMILES COC(=O)c1ccc(cc1)C1N(CCc2c[nH]c3ccccc23)C(=O)C(O)=C1C(=O)c1cccc(F)c1
Show InChI InChI=1S/C29H23FN2O5/c1-37-29(36)18-11-9-17(10-12-18)25-24(26(33)19-5-4-6-21(30)15-19)27(34)28(35)32(25)14-13-20-16-31-23-8-3-2-7-22(20)23/h2-12,15-16,25,31,34H,13-14H2,1H3
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n/an/an/an/a 1.10E+4n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Potentiation of rat recombinant GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response b...


J Med Chem 57: 2334-56 (2014)


Article DOI: 10.1021/jm401695d
BindingDB Entry DOI: 10.7270/Q2SB4786
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436086
PNG
(CHEMBL2397272)
Show SMILES COc1ccc(CCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C27H28BrNO4/c1-31-22-10-7-18(8-11-22)9-12-24-23-17-26(33-3)25(32-2)16-19(23)13-14-29(24)27(30)20-5-4-6-21(28)15-20/h4-8,10-11,15-17,24H,9,12-14H2,1-3H3
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n/an/an/an/a 1.10E+4n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50436080
PNG
(CHEMBL2397107)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(c2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C26H26N2O7/c1-32-20-7-9-21(10-8-20)35-16-23-22-15-25(34-3)24(33-2)14-17(22)11-12-27(23)26(29)18-5-4-6-19(13-18)28(30)31/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/an/an/a 1.10E+4n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...


J Med Chem 56: 5351-81 (2014)


Article DOI: 10.1021/jm400177t
BindingDB Entry DOI: 10.7270/Q26W9CH4
More data for this
Ligand-Target Pair
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