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Compile Data Set for Download or QSAR

Found 268 hits Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, AMPA 4'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112770
PNG
((+/-) Propane-2-sulfonic acid [2-(4-iodo-phenyl)-c...)
Show SMILES CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(I)cc1
Show InChI InChI=1S/C14H20INO2S/c1-10(2)19(17,18)16-14-5-3-4-13(14)11-6-8-12(15)9-7-11/h6-10,13-14,16H,3-5H2,1-2H3/t13-,14-/m1/s1
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n/an/an/an/a 22.6n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.


J Med Chem 45: 2101-11 (2002)


Article DOI: 10.1021/jm0105474
BindingDB Entry DOI: 10.7270/Q20R9NRB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112776
PNG
((+/-) Propane-2-sulfonic acid [2-(4-iodo-phenyl)-c...)
Show SMILES CC(C)S(=O)(=O)N[C@H]1CCC[C@@H]1c1ccc(I)cc1
Show InChI InChI=1S/C14H20INO2S/c1-10(2)19(17,18)16-14-5-3-4-13(14)11-6-8-12(15)9-7-11/h6-10,13-14,16H,3-5H2,1-2H3/t13-,14+/m1/s1
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n/an/an/an/a 32.8n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.


J Med Chem 45: 2101-11 (2002)


Article DOI: 10.1021/jm0105474
BindingDB Entry DOI: 10.7270/Q20R9NRB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112770
PNG
((+/-) Propane-2-sulfonic acid [2-(4-iodo-phenyl)-c...)
Show SMILES CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(I)cc1
Show InChI InChI=1S/C14H20INO2S/c1-10(2)19(17,18)16-14-5-3-4-13(14)11-6-8-12(15)9-7-11/h6-10,13-14,16H,3-5H2,1-2H3/t13-,14-/m1/s1
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n/an/an/an/a 45.8n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.


J Med Chem 45: 2101-11 (2002)


Article DOI: 10.1021/jm0105474
BindingDB Entry DOI: 10.7270/Q20R9NRB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191952
PNG
(4-cyano-3-(2'-cyano-biphenyl-4-yl)-5-ethyl-1-methy...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1C#N
Show InChI InChI=1S/C22H17N3O2/c1-3-19-18(13-24)20(21(22(26)27)25(19)2)15-10-8-14(9-11-15)17-7-5-4-6-16(17)12-23/h4-11H,3H2,1-2H3,(H,26,27)
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n/an/an/an/a 53n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191952
PNG
(4-cyano-3-(2'-cyano-biphenyl-4-yl)-5-ethyl-1-methy...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1C#N
Show InChI InChI=1S/C22H17N3O2/c1-3-19-18(13-24)20(21(22(26)27)25(19)2)15-10-8-14(9-11-15)17-7-5-4-6-16(17)12-23/h4-11H,3H2,1-2H3,(H,26,27)
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n/an/an/an/a 56n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112771
PNG
((+/-) Propane-2-sulfonic acid [2-(4-bromo-phenyl)-...)
Show SMILES CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(Br)cc1
Show InChI InChI=1S/C14H20BrNO2S/c1-10(2)19(17,18)16-14-5-3-4-13(14)11-6-8-12(15)9-7-11/h6-10,13-14,16H,3-5H2,1-2H3/t13-,14-/m1/s1
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n/an/an/an/a 68n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.


J Med Chem 45: 2101-11 (2002)


Article DOI: 10.1021/jm0105474
BindingDB Entry DOI: 10.7270/Q20R9NRB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191961
PNG
(4-cyano-5-ethyl-1-methyl-3-(2'-methylsulfanyl-biph...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1SC
Show InChI InChI=1S/C22H20N2O2S/c1-4-18-17(13-23)20(21(22(25)26)24(18)2)15-11-9-14(10-12-15)16-7-5-6-8-19(16)27-3/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 77n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191948
PNG
(4-cyano-5-ethyl-3-(2'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1F
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-16(12-23)19(20(21(25)26)24(18)2)14-10-8-13(9-11-14)15-6-4-5-7-17(15)22/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 80n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112778
PNG
((+/-) Propane-2-sulfonic acid [2-(4-bromo-phenyl)-...)
Show SMILES CC(C)S(=O)(=O)N[C@H]1CCC[C@@H]1c1ccc(Br)cc1
Show InChI InChI=1S/C14H20BrNO2S/c1-10(2)19(17,18)16-14-5-3-4-13(14)11-6-8-12(15)9-7-11/h6-10,13-14,16H,3-5H2,1-2H3/t13-,14+/m1/s1
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n/an/an/an/a 82.1n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.


J Med Chem 45: 2101-11 (2002)


Article DOI: 10.1021/jm0105474
BindingDB Entry DOI: 10.7270/Q20R9NRB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112776
PNG
((+/-) Propane-2-sulfonic acid [2-(4-iodo-phenyl)-c...)
Show SMILES CC(C)S(=O)(=O)N[C@H]1CCC[C@@H]1c1ccc(I)cc1
Show InChI InChI=1S/C14H20INO2S/c1-10(2)19(17,18)16-14-5-3-4-13(14)11-6-8-12(15)9-7-11/h6-10,13-14,16H,3-5H2,1-2H3/t13-,14+/m1/s1
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n/an/an/an/a 93.1n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.


J Med Chem 45: 2101-11 (2002)


Article DOI: 10.1021/jm0105474
BindingDB Entry DOI: 10.7270/Q20R9NRB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191961
PNG
(4-cyano-5-ethyl-1-methyl-3-(2'-methylsulfanyl-biph...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1SC
Show InChI InChI=1S/C22H20N2O2S/c1-4-18-17(13-23)20(21(22(25)26)24(18)2)15-11-9-14(10-12-15)16-7-5-6-8-19(16)27-3/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 105n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112772
PNG
((+/-) Propane-2-sulfonic acid [2-(3,5-difluoro-phe...)
Show SMILES CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1cc(F)cc(F)c1
Show InChI InChI=1S/C14H19F2NO2S/c1-9(2)20(18,19)17-14-5-3-4-13(14)10-6-11(15)8-12(16)7-10/h6-9,13-14,17H,3-5H2,1-2H3/t13-,14-/m1/s1
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n/an/an/an/a 118n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.


J Med Chem 45: 2101-11 (2002)


Article DOI: 10.1021/jm0105474
BindingDB Entry DOI: 10.7270/Q20R9NRB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112778
PNG
((+/-) Propane-2-sulfonic acid [2-(4-bromo-phenyl)-...)
Show SMILES CC(C)S(=O)(=O)N[C@H]1CCC[C@@H]1c1ccc(Br)cc1
Show InChI InChI=1S/C14H20BrNO2S/c1-10(2)19(17,18)16-14-5-3-4-13(14)11-6-8-12(15)9-7-11/h6-10,13-14,16H,3-5H2,1-2H3/t13-,14+/m1/s1
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n/an/an/an/a 130n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.


J Med Chem 45: 2101-11 (2002)


Article DOI: 10.1021/jm0105474
BindingDB Entry DOI: 10.7270/Q20R9NRB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50094020
PNG
(CHEMBL136801 | Propane-2-sulfonic acid [2-(4'-amin...)
Show SMILES CC(C)S(=O)(=O)NCC(C)c1ccc(cc1)-c1ccc(N)cc1
Show InChI InChI=1S/C18H24N2O2S/c1-13(2)23(21,22)20-12-14(3)15-4-6-16(7-5-15)17-8-10-18(19)11-9-17/h4-11,13-14,20H,12,19H2,1-3H3
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n/an/an/an/a 130n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Tested for potentiation towards human iGluR4 receptor expressed in HEK293 cells


J Med Chem 43: 4354-8 (2000)


Article DOI: 10.1021/jm0002836
BindingDB Entry DOI: 10.7270/Q2R2123P
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191957
PNG
(4-cyano-3-(2'-ethoxy-biphenyl-4-yl)-5-ethyl-1-meth...)
Show SMILES CCOc1ccccc1-c1ccc(cc1)-c1c(C#N)c(CC)n(C)c1C(O)=O
Show InChI InChI=1S/C23H22N2O3/c1-4-19-18(14-24)21(22(23(26)27)25(19)3)16-12-10-15(11-13-16)17-8-6-7-9-20(17)28-5-2/h6-13H,4-5H2,1-3H3,(H,26,27)
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n/an/an/an/a 146n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112771
PNG
((+/-) Propane-2-sulfonic acid [2-(4-bromo-phenyl)-...)
Show SMILES CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(Br)cc1
Show InChI InChI=1S/C14H20BrNO2S/c1-10(2)19(17,18)16-14-5-3-4-13(14)11-6-8-12(15)9-7-11/h6-10,13-14,16H,3-5H2,1-2H3/t13-,14-/m1/s1
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n/an/an/an/a 147n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.


J Med Chem 45: 2101-11 (2002)


Article DOI: 10.1021/jm0105474
BindingDB Entry DOI: 10.7270/Q20R9NRB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50330415
PNG
((R)-N-(2-(4'-(2-(methylsulfonamido)ethyl)biphenyl-...)
Show SMILES CC(C)S(=O)(=O)NC[C@H](C)c1ccc(cc1)-c1ccc(CCNS(C)(=O)=O)cc1
Show InChI InChI=1S/C21H30N2O4S2/c1-16(2)29(26,27)23-15-17(3)19-9-11-21(12-10-19)20-7-5-18(6-8-20)13-14-22-28(4,24)25/h5-12,16-17,22-23H,13-15H2,1-4H3/t17-/m0/s1
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n/an/an/an/a 150n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of GluR4 expressed in HEK293 cells


J Med Chem 53: 7271-9 (2010)


Article DOI: 10.1021/jm1000419
BindingDB Entry DOI: 10.7270/Q2W0965T
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191954
PNG
(3-(2'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1Cl
Show InChI InChI=1S/C21H17ClN2O2/c1-3-18-16(12-23)19(20(21(25)26)24(18)2)14-10-8-13(9-11-14)15-6-4-5-7-17(15)22/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 157n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191957
PNG
(4-cyano-3-(2'-ethoxy-biphenyl-4-yl)-5-ethyl-1-meth...)
Show SMILES CCOc1ccccc1-c1ccc(cc1)-c1c(C#N)c(CC)n(C)c1C(O)=O
Show InChI InChI=1S/C23H22N2O3/c1-4-19-18(14-24)21(22(23(26)27)25(19)3)16-12-10-15(11-13-16)17-8-6-7-9-20(17)28-5-2/h6-13H,4-5H2,1-3H3,(H,26,27)
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n/an/an/an/a 158n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50192216
PNG
(3-(4-tert-butylphenyl)-4-cyano-5-ethylthiophene-2-...)
Show SMILES CCc1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C18H19NO2S/c1-5-14-13(10-19)15(16(22-14)17(20)21)11-6-8-12(9-7-11)18(2,3)4/h6-9H,5H2,1-4H3,(H,20,21)
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n/an/an/an/a 183n/an/an/an/a



Lilly S.A.

Curated by ChEMBL


Assay Description
Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay


Bioorg Med Chem Lett 16: 5057-61 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.035
BindingDB Entry DOI: 10.7270/Q24749H7
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191948
PNG
(4-cyano-5-ethyl-3-(2'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1F
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-16(12-23)19(20(21(25)26)24(18)2)14-10-8-13(9-11-14)15-6-4-5-7-17(15)22/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 185n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112779
PNG
((+/-) Propane-2-sulfonic acid [2-(4-nitro-phenyl)-...)
Show SMILES CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C14H20N2O4S/c1-10(2)21(19,20)15-14-5-3-4-13(14)11-6-8-12(9-7-11)16(17)18/h6-10,13-15H,3-5H2,1-2H3/t13-,14-/m1/s1
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n/an/an/an/a 190n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.


J Med Chem 45: 2101-11 (2002)


Article DOI: 10.1021/jm0105474
BindingDB Entry DOI: 10.7270/Q20R9NRB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191955
PNG
(3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrol...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H18N2O2/c1-3-18-17(13-22)19(20(21(24)25)23(18)2)16-11-9-15(10-12-16)14-7-5-4-6-8-14/h4-12H,3H2,1-2H3,(H,24,25)
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n/an/an/an/a 213n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191959
PNG
(3-(4-tert-butylphenyl)-4-cyano-5-(methylthio)thiop...)
Show SMILES CSc1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C17H17NO2S2/c1-17(2,3)11-7-5-10(6-8-11)13-12(9-18)16(21-4)22-14(13)15(19)20/h5-8H,1-4H3,(H,19,20)
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n/an/an/an/a 214n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191959
PNG
(3-(4-tert-butylphenyl)-4-cyano-5-(methylthio)thiop...)
Show SMILES CSc1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C17H17NO2S2/c1-17(2,3)11-7-5-10(6-8-11)13-12(9-18)16(21-4)22-14(13)15(19)20/h5-8H,1-4H3,(H,19,20)
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n/an/an/an/a 214n/an/an/an/a



Lilly S.A.

Curated by ChEMBL


Assay Description
Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay


Bioorg Med Chem Lett 16: 5057-61 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.035
BindingDB Entry DOI: 10.7270/Q24749H7
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191949
PNG
(4-cyano-5-ethyl-3-(3'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1cccc(F)c1
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-17(12-23)19(20(21(25)26)24(18)2)14-9-7-13(8-10-14)15-5-4-6-16(22)11-15/h4-11H,3H2,1-2H3,(H,25,26)
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Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191954
PNG
(3-(2'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1Cl
Show InChI InChI=1S/C21H17ClN2O2/c1-3-18-16(12-23)19(20(21(25)26)24(18)2)14-10-8-13(9-11-14)15-6-4-5-7-17(15)22/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 225n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112770
PNG
((+/-) Propane-2-sulfonic acid [2-(4-iodo-phenyl)-c...)
Show SMILES CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(I)cc1
Show InChI InChI=1S/C14H20INO2S/c1-10(2)19(17,18)16-14-5-3-4-13(14)11-6-8-12(15)9-7-11/h6-10,13-14,16H,3-5H2,1-2H3/t13-,14-/m1/s1
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n/an/an/an/a 230n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of GluR4 expressed in HEK293 cells


J Med Chem 53: 7271-9 (2010)


Article DOI: 10.1021/jm1000419
BindingDB Entry DOI: 10.7270/Q2W0965T
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191951
PNG
(4-cyano-5-ethyl-3-(4'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-17(12-23)19(20(21(25)26)24(18)2)15-6-4-13(5-7-15)14-8-10-16(22)11-9-14/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 242n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112775
PNG
((+/-) Propane-2-sulfonic acid [2-(4-chloro-phenyl)...)
Show SMILES CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(Cl)cc1
Show InChI InChI=1S/C14H20ClNO2S/c1-10(2)19(17,18)16-14-5-3-4-13(14)11-6-8-12(15)9-7-11/h6-10,13-14,16H,3-5H2,1-2H3/t13-,14-/m1/s1
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n/an/an/an/a 247n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.


J Med Chem 45: 2101-11 (2002)


Article DOI: 10.1021/jm0105474
BindingDB Entry DOI: 10.7270/Q20R9NRB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50094034
PNG
(CHEMBL343972 | Propane-2-sulfonic acid [2-(4'-form...)
Show SMILES CC(C)S(=O)(=O)NCC(C)c1ccc(cc1)-c1ccc(C=O)cc1
Show InChI InChI=1S/C19H23NO3S/c1-14(2)24(22,23)20-12-15(3)17-8-10-19(11-9-17)18-6-4-16(13-21)5-7-18/h4-11,13-15,20H,12H2,1-3H3
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n/an/an/an/a 250n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Tested for potentiation towards human iGluR4 receptor expressed in HEK293 cells


J Med Chem 43: 4354-8 (2000)


Article DOI: 10.1021/jm0002836
BindingDB Entry DOI: 10.7270/Q2R2123P
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50094016
PNG
(CHEMBL343571 | Propane-2-sulfonic acid [2-(4'-meth...)
Show SMILES CC(C)S(=O)(=O)NCC(C)c1ccc(cc1)-c1ccc(C)cc1
Show InChI InChI=1S/C19H25NO2S/c1-14(2)23(21,22)20-13-16(4)17-9-11-19(12-10-17)18-7-5-15(3)6-8-18/h5-12,14,16,20H,13H2,1-4H3
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n/an/an/an/a 270n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Tested for potentiation towards human iGluR4 receptor expressed in HEK293 cells


J Med Chem 43: 4354-8 (2000)


Article DOI: 10.1021/jm0002836
BindingDB Entry DOI: 10.7270/Q2R2123P
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50192221
PNG
(3-(4-tert-butylphenyl)-4-cyano-5-(trifluoromethyl)...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1c(sc(c1C#N)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C17H14F3NO2S/c1-16(2,3)10-6-4-9(5-7-10)12-11(8-21)14(17(18,19)20)24-13(12)15(22)23/h4-7H,1-3H3,(H,22,23)
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n/an/an/an/a 273n/an/an/an/a



Lilly S.A.

Curated by ChEMBL


Assay Description
Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay


Bioorg Med Chem Lett 16: 5057-61 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.035
BindingDB Entry DOI: 10.7270/Q24749H7
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112772
PNG
((+/-) Propane-2-sulfonic acid [2-(3,5-difluoro-phe...)
Show SMILES CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1cc(F)cc(F)c1
Show InChI InChI=1S/C14H19F2NO2S/c1-9(2)20(18,19)17-14-5-3-4-13(14)10-6-11(15)8-12(16)7-10/h6-9,13-14,17H,3-5H2,1-2H3/t13-,14-/m1/s1
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n/an/an/an/a 281n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.


J Med Chem 45: 2101-11 (2002)


Article DOI: 10.1021/jm0105474
BindingDB Entry DOI: 10.7270/Q20R9NRB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50094024
PNG
((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...)
Show SMILES CC(C)S(=O)(=O)NCC(C)c1ccc(cc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C19H22N2O2S/c1-14(2)24(22,23)21-13-15(3)17-8-10-19(11-9-17)18-6-4-16(12-20)5-7-18/h4-11,14-15,21H,13H2,1-3H3
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n/an/an/an/a 290n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.


J Med Chem 45: 2101-11 (2002)


Article DOI: 10.1021/jm0105474
BindingDB Entry DOI: 10.7270/Q20R9NRB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50094024
PNG
((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...)
Show SMILES CC(C)S(=O)(=O)NCC(C)c1ccc(cc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C19H22N2O2S/c1-14(2)24(22,23)21-13-15(3)17-8-10-19(11-9-17)18-6-4-16(12-20)5-7-18/h4-11,14-15,21H,13H2,1-3H3
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n/an/an/an/a 290n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Tested for potentiation towards human iGluR4 receptor expressed in HEK293 cells


J Med Chem 43: 4354-8 (2000)


Article DOI: 10.1021/jm0002836
BindingDB Entry DOI: 10.7270/Q2R2123P
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50094024
PNG
((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...)
Show SMILES CC(C)S(=O)(=O)NCC(C)c1ccc(cc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C19H22N2O2S/c1-14(2)24(22,23)21-13-15(3)17-8-10-19(11-9-17)18-6-4-16(12-20)5-7-18/h4-11,14-15,21H,13H2,1-3H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of GluR4 expressed in HEK293 cells


J Med Chem 53: 7271-9 (2010)


Article DOI: 10.1021/jm1000419
BindingDB Entry DOI: 10.7270/Q2W0965T
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191969
PNG
(4-cyano-3-(4'-cyano-biphenyl-4-yl)-5-ethyl-1-methy...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H17N3O2/c1-3-19-18(13-24)20(21(22(26)27)25(19)2)17-10-8-16(9-11-17)15-6-4-14(12-23)5-7-15/h4-11H,3H2,1-2H3,(H,26,27)
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Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191958
PNG
(4-cyano-5-ethyl-3-(2'-methoxy-biphenyl-4-yl)-1-met...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1OC
Show InChI InChI=1S/C22H20N2O3/c1-4-18-17(13-23)20(21(22(25)26)24(18)2)15-11-9-14(10-12-15)16-7-5-6-8-19(16)27-3/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 386n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191962
PNG
(3-biphenyl-4-yl-4-cyano-1-methyl-5-methylsulfanyl-...)
Show SMILES CSc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H16N2O2S/c1-22-18(20(23)24)17(16(12-21)19(22)25-2)15-10-8-14(9-11-15)13-6-4-3-5-7-13/h3-11H,1-2H3,(H,23,24)
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PubMed
n/an/an/an/a 394n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191962
PNG
(3-biphenyl-4-yl-4-cyano-1-methyl-5-methylsulfanyl-...)
Show SMILES CSc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H16N2O2S/c1-22-18(20(23)24)17(16(12-21)19(22)25-2)15-10-8-14(9-11-15)13-6-4-3-5-7-13/h3-11H,1-2H3,(H,23,24)
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PubMed
n/an/an/an/a 394n/an/an/an/a



Lilly S.A.

Curated by ChEMBL


Assay Description
Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay


Bioorg Med Chem Lett 16: 5057-61 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.035
BindingDB Entry DOI: 10.7270/Q24749H7
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112781
PNG
((R,R) Propane-2-sulfonic acid [2-(4-cyano-phenyl)-...)
Show SMILES CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(cc1)C#N
Show InChI InChI=1S/C15H20N2O2S/c1-11(2)20(18,19)17-15-5-3-4-14(15)13-8-6-12(10-16)7-9-13/h6-9,11,14-15,17H,3-5H2,1-2H3/t14-,15-/m1/s1
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PubMed
n/an/an/an/a 403n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.


J Med Chem 45: 2101-11 (2002)


Article DOI: 10.1021/jm0105474
BindingDB Entry DOI: 10.7270/Q20R9NRB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50094024
PNG
((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...)
Show SMILES CC(C)S(=O)(=O)NCC(C)c1ccc(cc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C19H22N2O2S/c1-14(2)24(22,23)21-13-15(3)17-8-10-19(11-9-17)18-6-4-16(12-20)5-7-18/h4-11,14-15,21H,13H2,1-3H3
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n/an/an/an/a 420n/an/an/an/a



Lilly S.A.

Curated by ChEMBL


Assay Description
Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay


Bioorg Med Chem Lett 16: 5057-61 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.035
BindingDB Entry DOI: 10.7270/Q24749H7
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112777
PNG
((+/-) Propane-2-sulfonic acid (2-p-tolyl-cyclopent...)
Show SMILES CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(C)cc1
Show InChI InChI=1S/C15H23NO2S/c1-11(2)19(17,18)16-15-6-4-5-14(15)13-9-7-12(3)8-10-13/h7-11,14-16H,4-6H2,1-3H3/t14-,15-/m1/s1
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n/an/an/an/a 434n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.


J Med Chem 45: 2101-11 (2002)


Article DOI: 10.1021/jm0105474
BindingDB Entry DOI: 10.7270/Q20R9NRB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50192214
PNG
(3-(4-tert-butylphenyl)-4-cyano-5-(ethylthio)thioph...)
Show SMILES CCSc1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C18H19NO2S2/c1-5-22-17-13(10-19)14(15(23-17)16(20)21)11-6-8-12(9-7-11)18(2,3)4/h6-9H,5H2,1-4H3,(H,20,21)
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PubMed
n/an/an/an/a 440n/an/an/an/a



Lilly S.A.

Curated by ChEMBL


Assay Description
Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay


Bioorg Med Chem Lett 16: 5057-61 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.035
BindingDB Entry DOI: 10.7270/Q24749H7
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50192222
PNG
(3-(4-tert-butylphenyl)-4-cyano-5-(dimethylamino)th...)
Show SMILES CN(C)c1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C18H20N2O2S/c1-18(2,3)12-8-6-11(7-9-12)14-13(10-19)16(20(4)5)23-15(14)17(21)22/h6-9H,1-5H3,(H,21,22)
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PubMed
n/an/an/an/a 474n/an/an/an/a



Lilly S.A.

Curated by ChEMBL


Assay Description
Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay


Bioorg Med Chem Lett 16: 5057-61 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.035
BindingDB Entry DOI: 10.7270/Q24749H7
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50192221
PNG
(3-(4-tert-butylphenyl)-4-cyano-5-(trifluoromethyl)...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1c(sc(c1C#N)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C17H14F3NO2S/c1-16(2,3)10-6-4-9(5-7-10)12-11(8-21)14(17(18,19)20)24-13(12)15(22)23/h4-7H,1-3H3,(H,22,23)
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n/an/an/an/a 488n/an/an/an/a



Lilly S.A.

Curated by ChEMBL


Assay Description
Activity against human GLUR4 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay


Bioorg Med Chem Lett 16: 5057-61 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.035
BindingDB Entry DOI: 10.7270/Q24749H7
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50192223
PNG
(3-(4-tert-butylphenyl)-4-cyano-5-(methylsulfinyl)t...)
Show SMILES CS(=O)c1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C17H17NO3S2/c1-17(2,3)11-7-5-10(6-8-11)13-12(9-18)16(23(4)21)22-14(13)15(19)20/h5-8H,1-4H3,(H,19,20)
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PubMed
n/an/an/an/a 489n/an/an/an/a



Lilly S.A.

Curated by ChEMBL


Assay Description
Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay


Bioorg Med Chem Lett 16: 5057-61 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.035
BindingDB Entry DOI: 10.7270/Q24749H7
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112773
PNG
((+/-3b) N-{4'-[1-Methyl-2-(propane-2-sulfonylamino...)
Show SMILES CC(C)S(=O)(=O)NCC(C)c1ccc(cc1)-c1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C25H28N2O3S/c1-18(2)31(29,30)26-17-19(3)20-9-11-21(12-10-20)22-13-15-24(16-14-22)27-25(28)23-7-5-4-6-8-23/h4-16,18-19,26H,17H2,1-3H3,(H,27,28)
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PubMed
n/an/an/an/a 520n/an/an/an/a



NPS Allelix Corporation

Curated by ChEMBL


Assay Description
Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.


J Med Chem 45: 2101-11 (2002)


Article DOI: 10.1021/jm0105474
BindingDB Entry DOI: 10.7270/Q20R9NRB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50112771
PNG
((+/-) Propane-2-sulfonic acid [2-(4-bromo-phenyl)-...)
Show SMILES CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(Br)cc1
Show InChI InChI=1S/C14H20BrNO2S/c1-10(2)19(17,18)16-14-5-3-4-13(14)11-6-8-12(15)9-7-11/h6-10,13-14,16H,3-5H2,1-2H3/t13-,14-/m1/s1
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n/an/an/an/a 520n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of GluR4 expressed in HEK293 cells


J Med Chem 53: 7271-9 (2010)


Article DOI: 10.1021/jm1000419
BindingDB Entry DOI: 10.7270/Q2W0965T
More data for this
Ligand-Target Pair
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