Found 440 Enz. Inhib. hit(s) with Target = 'Glycine receptor subunit alpha-1' 
Affinity DataEC50: 0.000160nMAssay Description:Human embryonic kidney (HEK) 293 cells (ATCC CRL 1573) and/or Xenopus laevis oocytes were used for expressing the human a1-3 glycine receptor subunit...More data for this Ligand-Target Pair
Affinity DataEC50: 0.000160nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
Affinity DataEC50: 0.00120nMAssay Description:Human embryonic kidney (HEK) 293 cells (ATCC CRL 1573) and/or Xenopus laevis oocytes were used for expressing the human a1-3 glycine receptor subunit...More data for this Ligand-Target Pair
Affinity DataEC50: 0.00120nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0600nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0600nMAssay Description:Human embryonic kidney (HEK) 293 cells (ATCC CRL 1573) and/or Xenopus laevis oocytes were used for expressing the human a1-3 glycine receptor subunit...More data for this Ligand-Target Pair
Affinity DataEC50: 0.430nMAssay Description:Human embryonic kidney (HEK) 293 cells (ATCC CRL 1573) and/or Xenopus laevis oocytes were used for expressing the human a1-3 glycine receptor subunit...More data for this Ligand-Target Pair
Affinity DataEC50: 0.430nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Positive allosteric modulation of human glycine alpha1beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current respon...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 32nMAssay Description:Positive allosteric modulation of human glycine alpha1 receptor expressed in HEK293T cells assessed as glycine-induced increase incurrent response af...More data for this Ligand-Target Pair
Affinity DataEC50: 171nMAssay Description:Positive allosteric modulation of human GlyRalpha1beta expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium ...More data for this Ligand-Target Pair
Affinity DataEC50: 171nMAssay Description:Positive allosteric modulation of human glycine alpha1beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current respon...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1(Mus musculus)
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Affinity DataEC50: 268nMAssay Description:Positive allosteric modulation of mouse GlyRalpha1 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMAssay Description:Positive allosteric modulation of human GlyRalpha1beta assessed as increase in glycine-induced chloride ion flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 320nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Affinity DataEC50: 320nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Affinity DataEC50: 327nMAssay Description:Positive allosteric modulation of human GlyRalpha1 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-...More data for this Ligand-Target Pair
Affinity DataEC50: 327nMAssay Description:Positive allosteric modulation of human glycine alpha1 receptor expressed in HEK293T cells assessed as glycine-induced increase incurrent response af...More data for this Ligand-Target Pair
Affinity DataEC50: 330nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Affinity DataEC50: 380nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Affinity DataEC50: 400nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Affinity DataEC50: 500nMAssay Description:Agonist activity at human recombinant alpha 1 GlyR expressed in HEK293 cells assessed as potentiation of glycine current by whole cell patch clamp as...More data for this Ligand-Target Pair
Affinity DataEC50: 590nMAssay Description:Positive allosteric modulation of recombinant human glycine receptor alpha1 expressed in HEK293 cells assessed as increase in glycine-induced current...More data for this Ligand-Target Pair
Affinity DataEC50: 600nMAssay Description:Positive allosteric modulation of human GlyRalpha1beta assessed as increase in glycine-induced chloride ion flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+3nMAssay Description:Agonist activity at human recombinant alpha 1 GlyR expressed in HEK293 cells assessed as potentiation of glycine current by whole cell patch clamp as...More data for this Ligand-Target Pair
Affinity DataEC50: 1.30E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Affinity DataEC50: 1.30E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Affinity DataEC50: 1.70E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Affinity DataEC50: 1.80E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Affinity DataEC50: 2.50E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Affinity DataEC50: 3.20E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Affinity DataEC50: 4.20E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Affinity DataEC50: 1.26E+4nMAssay Description:Positive allosteric modulatory activity at recombinant human glycine alpha1 receptor expressed in HEK293 cells assessed as potentiation of glycine-in...More data for this Ligand-Target Pair
Affinity DataEC50: 9.55E+4nMAssay Description:Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [3H]strychnine from human glycine receptor subunit alpha-1 expressed in HEK293 cell membranes preincubated for 30 mins followed by [3...More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Displacement of [3H]strychnine from glycine receptor alpha 1 in rat brain synaptic membranesMore data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Displacement of [3H]strychnine from glycine receptor alpha 1 in rat brain synaptic membranesMore data for this Ligand-Target Pair
Affinity DataKi: 23nMAssay Description:Displacement of [3H]strychnine from recombinant human glycine receptor alpha 1 expressed in HEK293 cell membranes after 30 mins by liquid scintillati...More data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Displacement of [3H]strychnine from recombinant human glycine receptor alpha 1 expressed in HEK293 cell membranes after 30 mins by liquid scintillati...More data for this Ligand-Target Pair
Affinity DataKi: 67nMAssay Description:Displacement of [3H]strychnine from recombinant human glycine receptor alpha 1 expressed in HEK293 cell membranes after 30 mins by liquid scintillati...More data for this Ligand-Target Pair
Affinity DataKi: 81nMAssay Description:Displacement of [3H]strychnine from human glycine receptor subunit alpha-1 expressed in HEK293 cell membranes preincubated for 30 mins followed by [3...More data for this Ligand-Target Pair
Affinity DataKi: 91nMAssay Description:Displacement of [3H]strychnine from human glycine receptor subunit alpha-1 expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 123nMAssay Description:Displacement of [3H]strychnine from human glycine receptor subunit alpha-1 expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 189nMAssay Description:Displacement of [3H]strychnine from recombinant human glycine receptor alpha 1 expressed in HEK293 cell membranes after 30 mins by liquid scintillati...More data for this Ligand-Target Pair
Affinity DataKi: 204nMAssay Description:Displacement of [3H]strychnine from human glycine receptor subunit alpha-1 expressed in HEK293 cell membranes preincubated for 30 mins followed by [3...More data for this Ligand-Target Pair
Affinity DataKi: 241nMAssay Description:Displacement of [3H]strychnine from recombinant human glycine receptor alpha 1 expressed in HEK293 cell membranes after 30 mins by liquid scintillati...More data for this Ligand-Target Pair
Affinity DataKi: 370nMAssay Description:Displacement of [3H]strychnine from recombinant human glycine receptor alpha 1 expressed in HEK293 cell membranes after 30 mins by liquid scintillati...More data for this Ligand-Target Pair
Affinity DataKi: 436nMAssay Description:Displacement of [3H]strychnine from human glycine receptor subunit alpha-1 expressed in HEK293 cell membranes preincubated for 30 mins followed by [3...More data for this Ligand-Target Pair
Affinity DataKi: 741nMAssay Description:Displacement of [3H]strychnine from human glycine receptor subunit alpha-1 expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
