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Found 4425 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 8'
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataEC50:  216nMAssay Description:Inhibition of recombinant human HDAC8 expressed in baculovirus expression system using FDL as substrate incubated for 3 hrs by by fluorescence-based ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM32203(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)
Affinity DataEC50:  1.11E+4nMAssay Description:Substrate-dependent activation of HDAC8 (unknown origin) using FLUOR DE LYS as substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50239391(2-Mercapto-Benzoic Acid | CHEBI:59124 | THIOSALICY...)
Affinity DataEC50:  1.69E+4nMAssay Description:Substrate-dependent activation of HDAC8 (unknown origin) using FLUOR DE LYS as substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50465051(CHEMBL4285950)
Affinity DataEC50:  3.41E+5nMAssay Description:Inhibition of human HDAC8 using RHK(Ac)K(Ac)AMC as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347454(MO-OH-TM | US9790158, 5)
Affinity DataKi:  0.0400nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50123957((E)-5-(3-Benzenesulfonylamino-phenyl)-pent-2-en-4-...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347452(MO-OH-SM | US9790158, 3)
Affinity DataKi:  0.140nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347330(MO-OH-PHE | US9790158, 1)
Affinity DataKi:  0.170nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347453(MO-OH-DM | US9790158, 4)
Affinity DataKi:  0.440nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347330(MO-OH-PHE | US9790158, 1)
Affinity DataKi:  0.530nMAssay Description:Competitive inhibition of human recombinant HDAC8 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347330(MO-OH-PHE | US9790158, 1)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant HDAC8 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347456(US9790158, 7)
Affinity DataKi:  1.36nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347457(US9790158, 8)
Affinity DataKi:  1.42nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50492541(CHEMBL2408242)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant HDAC8 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347460(US9790158, 11)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human recombinant HDAC8 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50492540(CHEMBL2408243)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human recombinant HDAC8 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM348884(US9790158, 10)
Affinity DataKi:  2.69nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50210141(CHEMBL388195 | methyl (3S,6S,9S)-9-acetamido-6-[5-...)
Affinity DataKi:  5.32nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50602203(CHEMBL5171086)
Affinity DataKi:  5.5nMAssay Description:Competitive inhibition of human HDAC8 using Abz-SRGGK(STFA)FFRR-NH2 (S) as substrate by Lineweaver-burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347451(MO-OH-NAP | US9790158, 2)
Affinity DataKi:  7.63nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50492542(CHEMBL2408248)
Affinity DataKi:  7.90nMAssay Description:Inhibition of human recombinant HDAC8 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347460(US9790158, 11)
Affinity DataKi:  10.1nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50263458(CHEMBL4085143)
Affinity DataKi:  13nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in baculovirus-infected insect cells using RHK(Ac)K(Ac)AMC ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM348884(US9790158, 10)
Affinity DataKi:  13nMAssay Description:Inhibition of human recombinant HDAC8 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50353227(CHEMBL3215861)
Affinity DataKi:  19nMAssay Description:Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM348883(US9790158, 6)
Affinity DataKi:  19.4nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  22nMAssay Description:Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataKi:  22nMAssay Description:Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347461(US9790158, 12)
Affinity DataKi:  23.3nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataKi:  24nMAssay Description:Inhibition of human recombinant HDAC8 using fluorogenic HDAC substrate after 15 mins by fluorimetrc methodMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  25nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50602192(CHEMBL5174998)
Affinity DataKi:  31nMAssay Description:Competitive inhibition of human HDAC8 using Abz-SRGGK(STFA)FFRR-NH2 (S) as substrate by Lineweaver-burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105329(CHEMBL1213492)
Affinity DataKi:  39nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50263451(CHEMBL4065283)
Affinity DataKi:  40nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in baculovirus-infected insect cells using RHK(Ac)K(Ac)AMC ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataKi:  45nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataKi:  45nMAssay Description:Inhibition of C-terminal His-tagged human recombinant full-length HDAC8 expressed in baculovirus expression system assessed as reduction in 7-amino-4...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataKi:  48nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50353230(CHEMBL1830420)
Affinity DataKi:  54nMAssay Description:Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50353233(CHEMBL1830536)
Affinity DataKi:  55nMAssay Description:Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50353231(CHEMBL1830422)
Affinity DataKi:  57nMAssay Description:Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50353229(CHEMBL1830397)
Affinity DataKi:  65nMAssay Description:Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataKi:  70nMAssay Description:Inhibition of human recombinant HDAC8 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50353228(CHEMBL1830396)
Affinity DataKi:  78nMAssay Description:Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50248476(CHEMBL491316 | N-hydroxy-3-(2-phenethyl-1-(2-(pyrr...)
Affinity DataKi:  82nMAssay Description:Inhibition of recombinant HDAC8 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347452(MO-OH-SM | US9790158, 3)
Affinity DataKi:  84nMAssay Description:Inhibition of human recombinant HDAC8 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50263447(CHEMBL4062190)
Affinity DataKi:  93nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in baculovirus-infected insect cells using RHK(Ac)K(Ac)AMC ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50353234(CHEMBL1830537)
Affinity DataKi:  94nMAssay Description:Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50248476(CHEMBL491316 | N-hydroxy-3-(2-phenethyl-1-(2-(pyrr...)
Affinity DataKi:  95nMAssay Description:Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Affinity DataKi:  96nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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