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Found 390 hits Enz. Inhib. hit(s) with Target = 'Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM50294835
PNG
(4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,30-31H,13H2,(H,27,29)/t16-,17+
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n/an/an/an/a 200n/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...


J Med Chem 55: 1360-7 (2012)

More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM50294836
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Oc1c2[C@H]3CC[C@H](C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C25H21N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-5,8-12,16-17,30-31H,6-7,13H2,(H,27,29)/t16-,17+
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n/an/an/an/a 200n/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...


J Med Chem 55: 1360-7 (2012)

More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM50294799
PNG
(CHEMBL551249 | N-(4-Bromo-phenyl)-4-((1R,2S,6R,7S)...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C22H17BrN2O3/c23-15-5-7-16(8-6-15)24-20(26)12-3-9-17(10-4-12)25-21(27)18-13-1-2-14(11-13)19(18)22(25)28/h1-10,13-14,27-28H,11H2,(H,24,26)/t13-,14+
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n/an/an/an/a 1.00E+3n/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...


J Med Chem 55: 1360-7 (2012)

More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM50382971
PNG
(CHEMBL2030486)
Show SMILES CO[C@H]1CCCC[C@@H]1NC(=O)c1ccc(cc1)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O
Show InChI InChI=1S/C23H26N2O4/c1-29-18-5-3-2-4-17(18)24-21(26)13-8-10-16(11-9-13)25-22(27)19-14-6-7-15(12-14)20(19)23(25)28/h6-11,14-15,17-18,27-28H,2-5,12H2,1H3,(H,24,26)/t14-,15+,17-,18-/m0/s1
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n/an/an/an/a 2.00E+3n/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...


J Med Chem 55: 1360-7 (2012)

More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM50294835
PNG
(4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,30-31H,13H2,(H,27,29)/t16-,17+
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n/an/an/an/a 5.00E+3n/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...


J Med Chem 55: 1360-7 (2012)

More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM50294816
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)NCc1ccncc1
Show InChI InChI=1S/C22H19N3O3/c26-20(24-12-13-7-9-23-10-8-13)14-3-5-17(6-4-14)25-21(27)18-15-1-2-16(11-15)19(18)22(25)28/h1-10,15-16,27-28H,11-12H2,(H,24,26)/t15-,16+
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n/an/an/an/a 1.00E+4n/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...


J Med Chem 55: 1360-7 (2012)

More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM50294813
PNG
(CHEMBL560509 | N-Benzyl-4-((1R,2S,6R,7S)-3,5-dioxo...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C23H20N2O3/c26-21(24-13-14-4-2-1-3-5-14)15-8-10-18(11-9-15)25-22(27)19-16-6-7-17(12-16)20(19)23(25)28/h1-11,16-17,27-28H,12-13H2,(H,24,26)/t16-,17+
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n/an/an/an/a 2.00E+4n/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...


J Med Chem 55: 1360-7 (2012)

More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM50382969
PNG
(CHEMBL2030485)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C22H18N2O3/c25-20(23-16-4-2-1-3-5-16)13-8-10-17(11-9-13)24-21(26)18-14-6-7-15(12-14)19(18)22(24)27/h1-11,14-15,26-27H,12H2,(H,23,25)/t14-,15+
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n/an/an/an/a>2.50E+4n/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...


J Med Chem 55: 1360-7 (2012)

More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM50294819
PNG
(CHEMBL564157 | N-Cyclohexyl-4-((1R,2S,6R,7S)-3,5-d...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)NC1CCCCC1
Show InChI InChI=1S/C22H24N2O3/c25-20(23-16-4-2-1-3-5-16)13-8-10-17(11-9-13)24-21(26)18-14-6-7-15(12-14)19(18)22(24)27/h6-11,14-16,26-27H,1-5,12H2,(H,23,25)/t14-,15+
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n/an/an/an/a>2.50E+4n/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...


J Med Chem 55: 1360-7 (2012)

More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM50310190
PNG
(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
Show SMILES Cc1ccc(cc1)-c1cc(=O)c2ccccc2o1
Show InChI InChI=1S/C16H12O2/c1-11-6-8-12(9-7-11)16-10-14(17)13-4-2-3-5-15(13)18-16/h2-10H,1H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of Oulu

Curated by ChEMBL


Assay Description
Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...


J Med Chem 56: 3507-17 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM89825
PNG
(2-(4-Fluoro-phenyl)-chromen-4-one | 2-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)-c1cc(=O)c2ccccc2o1
Show InChI InChI=1S/C15H9FO2/c16-11-7-5-10(6-8-11)15-9-13(17)12-3-1-2-4-14(12)18-15/h1-9H
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of Oulu

Curated by ChEMBL


Assay Description
Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...


J Med Chem 56: 3507-17 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM50157555
PNG
(2-(3,4-dihydroxyphenyl)-4H-chromen-4-one | 3',4'-d...)
Show SMILES Oc1ccc(cc1O)-c1cc(=O)c2ccccc2o1
Show InChI InChI=1S/C15H10O4/c16-11-6-5-9(7-13(11)18)15-8-12(17)10-3-1-2-4-14(10)19-15/h1-8,16,18H
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n/an/a 170n/an/an/an/an/an/a



University of Oulu

Curated by ChEMBL


Assay Description
Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...


J Med Chem 56: 3507-17 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM50431165
PNG
(2-(3-hydroxyphenyl)-4H-chromen-4-one (2) | CHEMBL1...)
Show SMILES Oc1cccc(c1)-c1cc(=O)c2ccccc2o1
Show InChI InChI=1S/C15H10O3/c16-11-5-3-4-10(8-11)15-9-13(17)12-6-1-2-7-14(12)18-15/h1-9,16H
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n/an/a 310n/an/an/an/an/an/a



University of Oulu

Curated by ChEMBL


Assay Description
Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...


J Med Chem 56: 3507-17 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM50077325
PNG
(2-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-one |...)
Show SMILES Oc1ccc2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H10O5/c16-9-2-3-10-12(18)7-14(20-15(10)6-9)8-1-4-11(17)13(19)5-8/h1-7,16-17,19H
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n/an/a 870n/an/an/an/an/an/a



University of Oulu

Curated by ChEMBL


Assay Description
Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...


J Med Chem 56: 3507-17 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM85573
PNG
(7-Hydroxy-flavone, 5h)
Show SMILES COc1ccc(cc1)-c1cc(=O)c2ccc(O)cc2o1
Show InChI InChI=1S/C16H12O4/c1-19-12-5-2-10(3-6-12)15-9-14(18)13-7-4-11(17)8-16(13)20-15/h2-9,17H,1H3
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n/an/a 450n/an/an/an/an/an/a



University of Oulu

Curated by ChEMBL


Assay Description
Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...


J Med Chem 56: 3507-17 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM26659
PNG
(7,3-dihydroxyflavone | 7-hydroxy-2-(3-hydroxypheny...)
Show SMILES Oc1cccc(c1)-c1cc(=O)c2ccc(O)cc2o1
Show InChI InChI=1S/C15H10O4/c16-10-3-1-2-9(6-10)14-8-13(18)12-5-4-11(17)7-15(12)19-14/h1-8,16-17H
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n/an/a 620n/an/an/an/an/an/a



University of Oulu

Curated by ChEMBL


Assay Description
Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...


J Med Chem 56: 3507-17 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM7459
PNG
(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of Oulu

Curated by ChEMBL


Assay Description
Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...


J Med Chem 56: 3507-17 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM7458
PNG
(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Show SMILES Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
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n/an/a 2.90E+3n/an/an/an/an/an/a



University of Oulu

Curated by ChEMBL


Assay Description
Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...


J Med Chem 56: 3507-17 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM50028962
PNG
(CHEMBL275638 | flavone)
Show SMILES O=c1cc(oc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H
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n/an/a 140n/an/an/an/an/an/a



University of Oulu

Curated by ChEMBL


Assay Description
Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...


J Med Chem 56: 3507-17 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM60784
PNG
(US9163003, 19)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCCN(CCC2NC(=O)C3=C(CCOC3)N2)C1=O
Show InChI InChI=1S/C27H36N4O5/c1-35-20-6-4-18(5-7-20)25(32)19-8-13-30(14-9-19)23-3-2-12-31(27(23)34)15-10-24-28-22-11-16-36-17-21(22)26(33)29-24/h4-7,19,23-24,28H,2-3,8-17H2,1H3,(H,29,33)/t23-,24?/m1/s1
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n/an/a 9n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM60785
PNG
(US9163003, 20)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCCN(CCC2NC(=O)C3=C(CCOC3)N2)C1=O
Show InChI InChI=1S/C27H36N4O5/c1-35-20-6-4-18(5-7-20)25(32)19-8-13-30(14-9-19)23-3-2-12-31(27(23)34)15-10-24-28-22-11-16-36-17-21(22)26(33)29-24/h4-7,19,23-24,28H,2-3,8-17H2,1H3,(H,29,33)/t23-,24?/m0/s1
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n/an/a 218n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185793
PNG
(US9163003, 1)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2cccc(Cl)c2[N+]#[C-])C1=O
Show InChI InChI=1S/C25H26ClN3O3/c1-27-23-19(4-3-5-21(23)26)16-29-15-12-22(25(29)31)28-13-10-18(11-14-28)24(30)17-6-8-20(32-2)9-7-17/h3-9,18,22H,10-16H2,2H3
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n/an/a 81n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185794
PNG
(US9163003, 2)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C25H30N4O5/c1-33-18-4-2-16(3-5-18)23(30)17-6-10-28(11-7-17)21-8-12-29(25(21)32)14-22-26-20-9-13-34-15-19(20)24(31)27-22/h2-5,17,21H,6-15H2,1H3,(H,26,27,31)
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n/an/a 15n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185795
PNG
(US9163003, 3)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C25H30N4O5/c1-33-18-4-2-16(3-5-18)23(30)17-6-10-28(11-7-17)21-8-12-29(25(21)32)14-22-26-20-9-13-34-15-19(20)24(31)27-22/h2-5,17,21H,6-15H2,1H3,(H,26,27,31)/t21-/m0/s1
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n/an/a 9.5n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185796
PNG
(US9163003, 4)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C25H30N4O5/c1-33-18-4-2-16(3-5-18)23(30)17-6-10-28(11-7-17)21-8-12-29(25(21)32)14-22-26-20-9-13-34-15-19(20)24(31)27-22/h2-5,17,21H,6-15H2,1H3,(H,26,27,31)/t21-/m1/s1
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n/an/a 600n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185797
PNG
(US9163003, 5)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2ccc(Cl)c(c2)C#N)C1=O
Show InChI InChI=1S/C25H26ClN3O3/c1-32-21-5-3-18(4-6-21)24(30)19-8-11-28(12-9-19)23-10-13-29(25(23)31)16-17-2-7-22(26)20(14-17)15-27/h2-7,14,19,23H,8-13,16H2,1H3
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n/an/a 15n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185798
PNG
(US9163003, 6)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3n(C)ncc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C24H28N6O4/c1-28-22-18(13-25-28)23(32)27-20(26-22)14-30-12-9-19(24(30)33)29-10-7-16(8-11-29)21(31)15-3-5-17(34-2)6-4-15/h3-6,13,16,19H,7-12,14H2,1-2H3,(H,26,27,32)
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n/an/a 25n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185799
PNG
(US9163003, 7)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3ccsc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C24H26N4O4S/c1-32-17-4-2-15(3-5-17)21(29)16-6-10-27(11-7-16)19-8-12-28(24(19)31)14-20-25-18-9-13-33-22(18)23(30)26-20/h2-5,9,13,16,19H,6-8,10-12,14H2,1H3,(H,25,26,30)
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n/an/a 83n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185800
PNG
(US9163003, 8)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3sc(C)cc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C25H28N4O4S/c1-15-13-19-23(31)26-21(27-24(19)34-15)14-29-12-9-20(25(29)32)28-10-7-17(8-11-28)22(30)16-3-5-18(33-2)6-4-16/h3-6,13,17,20H,7-12,14H2,1-2H3,(H,26,27,31)
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n/an/a 141n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185801
PNG
(US9163003, 9)
Show SMILES Clc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C24H27ClN4O4/c25-17-3-1-15(2-4-17)22(30)16-5-9-28(10-6-16)20-7-11-29(24(20)32)13-21-26-19-8-12-33-14-18(19)23(31)27-21/h1-4,16,20H,5-14H2,(H,26,27,31)
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n/an/a 23n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185802
PNG
(US9163003, 10)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C24H27FN4O4/c25-17-3-1-15(2-4-17)22(30)16-5-9-28(10-6-16)20-7-11-29(24(20)32)13-21-26-19-8-12-33-14-18(19)23(31)27-21/h1-4,16,20H,5-14H2,(H,26,27,31)
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n/an/a 6n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185803
PNG
(US9163003, 11)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C24H27FN4O4/c25-17-3-1-15(2-4-17)22(30)16-5-9-28(10-6-16)20-7-11-29(24(20)32)13-21-26-19-8-12-33-14-18(19)23(31)27-21/h1-4,16,20H,5-14H2,(H,26,27,31)/t20-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185804
PNG
(US9163003, 12)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C24H27FN4O4/c25-17-3-1-15(2-4-17)22(30)16-5-9-28(10-6-16)20-7-11-29(24(20)32)13-21-26-19-8-12-33-14-18(19)23(31)27-21/h1-4,16,20H,5-14H2,(H,26,27,31)/t20-/m1/s1
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n/an/a 2.12E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185805
PNG
(US9163003, 13)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C26H32N4O5/c1-16-13-18(3-4-22(16)34-2)24(31)17-5-9-29(10-6-17)21-7-11-30(26(21)33)14-23-27-20-8-12-35-15-19(20)25(32)28-23/h3-4,13,17,21H,5-12,14-15H2,1-2H3,(H,27,28,32)/t21-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185806
PNG
(US9163003, 14)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C26H32N4O5/c1-16-13-18(3-4-22(16)34-2)24(31)17-5-9-29(10-6-17)21-7-11-30(26(21)33)14-23-27-20-8-12-35-15-19(20)25(32)28-23/h3-4,13,17,21H,5-12,14-15H2,1-2H3,(H,27,28,32)/t21-/m1/s1
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n/an/a 206n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185807
PNG
(US9163003, 15)
Show SMILES COc1ccc2C(=O)C3(Cc2c1)CCN(CC3)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C26H30N4O5/c1-34-17-2-3-18-16(12-17)13-26(23(18)31)6-9-29(10-7-26)21-4-8-30(25(21)33)14-22-27-20-5-11-35-15-19(20)24(32)28-22/h2-3,12,21H,4-11,13-15H2,1H3,(H,27,28,32)
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n/an/a 18n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185825
PNG
(US9163003, 16)
Show SMILES COc1ccc2C(=O)C3(Cc2c1)CCN(CC3)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C26H30N4O5/c1-34-17-2-3-18-16(12-17)13-26(23(18)31)6-9-29(10-7-26)21-4-8-30(25(21)33)14-22-27-20-5-11-35-15-19(20)24(32)28-22/h2-3,12,21H,4-11,13-15H2,1H3,(H,27,28,32)/t21-/m0/s1
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n/an/a<8.60n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185826
PNG
(US9163003, 17)
Show SMILES COc1ccc2C(=O)C3(Cc2c1)CCN(CC3)[C@@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C26H30N4O5/c1-34-17-2-3-18-16(12-17)13-26(23(18)31)6-9-29(10-7-26)21-4-8-30(25(21)33)14-22-27-20-5-11-35-15-19(20)24(32)28-22/h2-3,12,21H,4-11,13-15H2,1H3,(H,27,28,32)/t21-/m1/s1
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n/an/a 1.72E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185808
PNG
(US9163003, 18)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C26H32N4O5/c1-34-19-6-4-17(5-7-19)24(31)18-8-12-29(13-9-18)22-3-2-11-30(26(22)33)15-23-27-21-10-14-35-16-20(21)25(32)28-23/h4-7,18,22H,2-3,8-16H2,1H3,(H,27,28,32)
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n/an/a 15n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185809
PNG
(US9163003, 21)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C25H30N4O4/c1-33-18-7-5-16(6-8-18)23(30)17-9-12-28(13-10-17)21-11-14-29(25(21)32)15-22-26-20-4-2-3-19(20)24(31)27-22/h5-8,17,21H,2-4,9-15H2,1H3,(H,26,27,31)
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n/an/a 17n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185810
PNG
(US9163003, 22)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nccc(=O)[nH]2)C1=O
Show InChI InChI=1S/C22H26N4O4/c1-30-17-4-2-15(3-5-17)21(28)16-7-11-25(12-8-16)18-9-13-26(22(18)29)14-19-23-10-6-20(27)24-19/h2-6,10,16,18H,7-9,11-14H2,1H3,(H,23,24,27)
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n/an/a 764n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185811
PNG
(US9163003, 23)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc(C)cc(=O)[nH]2)C1=O
Show InChI InChI=1S/C23H28N4O4/c1-15-13-21(28)25-20(24-15)14-27-12-9-19(23(27)30)26-10-7-17(8-11-26)22(29)16-3-5-18(31-2)6-4-16/h3-6,13,17,19H,7-12,14H2,1-2H3,(H,24,25,28)
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n/an/a 137n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185812
PNG
(US9163003, 24)
Show SMILES CCc1cc(=O)[nH]c(CN2CCC(N3CCC(CC3)C(=O)c3ccc(OC)cc3)C2=O)n1
Show InChI InChI=1S/C24H30N4O4/c1-3-18-14-22(29)26-21(25-18)15-28-13-10-20(24(28)31)27-11-8-17(9-12-27)23(30)16-4-6-19(32-2)7-5-16/h4-7,14,17,20H,3,8-13,15H2,1-2H3,(H,25,26,29)
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n/an/a 53n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185813
PNG
(US9163003, 25)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2ncc(C)c(=O)[nH]2)C1=O
Show InChI InChI=1S/C23H28N4O4/c1-15-13-24-20(25-22(15)29)14-27-12-9-19(23(27)30)26-10-7-17(8-11-26)21(28)16-3-5-18(31-2)6-4-16/h3-6,13,17,19H,7-12,14H2,1-2H3,(H,24,25,29)
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n/an/a 36n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185814
PNG
(US9163003, 26)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc(C)c(C)c(=O)[nH]2)C1=O
Show InChI InChI=1S/C24H30N4O4/c1-15-16(2)25-21(26-23(15)30)14-28-13-10-20(24(28)31)27-11-8-18(9-12-27)22(29)17-4-6-19(32-3)7-5-17/h4-7,18,20H,8-14H2,1-3H3,(H,25,26,30)
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n/an/a 26n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185815
PNG
(US9163003, 27)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3ccccc(=O)c3[nH]2)C1=O
Show InChI InChI=1S/C26H28N4O4/c1-34-19-8-6-17(7-9-19)25(32)18-10-13-29(14-11-18)21-12-15-30(26(21)33)16-23-27-20-4-2-3-5-22(31)24(20)28-23/h2-9,18,21H,10-16H2,1H3,(H,27,28)
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n/an/a 19n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185816
PNG
(US9163003, 28)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3ccccc(=O)c3[nH]2)C1=O
Show InChI InChI=1S/C27H30N4O4/c1-17-15-19(7-8-23(17)35-2)26(33)18-9-12-30(13-10-18)21-11-14-31(27(21)34)16-24-28-20-5-3-4-6-22(32)25(20)29-24/h3-8,15,18,21H,9-14,16H2,1-2H3,(H,28,29)/t21-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185817
PNG
(US9163003, 29)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2nc3ccccc(=O)c3[nH]2)C1=O
Show InChI InChI=1S/C27H30N4O4/c1-17-15-19(7-8-23(17)35-2)26(33)18-9-12-30(13-10-18)21-11-14-31(27(21)34)16-24-28-20-5-3-4-6-22(32)25(20)29-24/h3-8,15,18,21H,9-14,16H2,1-2H3,(H,28,29)/t21-/m1/s1
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n/an/a 112n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185818
PNG
(US9163003, 30)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3ccccc(=O)c3[nH]2)C1=O
Show InChI InChI=1S/C26H28N4O4/c1-34-19-8-6-17(7-9-19)25(32)18-10-13-29(14-11-18)21-12-15-30(26(21)33)16-23-27-20-4-2-3-5-22(31)24(20)28-23/h2-9,18,21H,10-16H2,1H3,(H,27,28)/t21-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM185819
PNG
(US9163003, 31)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2nc3ccccc(=O)c3[nH]2)C1=O
Show InChI InChI=1S/C26H28N4O4/c1-34-19-8-6-17(7-9-19)25(32)18-10-13-29(14-11-18)21-12-15-30(26(21)33)16-23-27-20-4-2-3-5-22(31)24(20)28-23/h2-9,18,21H,10-16H2,1H3,(H,27,28)/t21-/m1/s1
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n/an/a 390n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...


Citation and Details
More data for this
Ligand-Target Pair
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