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Found 7476 Enz. Inhib. hit(s) with Target = 'Integrase'
TargetIntegrase(Human immunodeficiency virus 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataEC50:  0.210nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity incubated for 10 mins by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetIntegrase(Human immunodeficiency virus 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataEC50:  1nMAssay Description:Inhibition of HIV-1 integrase mutant strand transfer activity incubated for 10 mins by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273913(CHEMBL4127663)
Affinity DataEC50:  1nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273950(CHEMBL4128240)
Affinity DataEC50:  1nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50062551(CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572)
Affinity DataEC50:  1.5nMAssay Description:Inhibition of HIV-1 NL4-3 integrase T97A/Y143C double mutantMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50062551(CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572)
Affinity DataEC50:  1.5nMAssay Description:Inhibition of wild type HIV-1 NL4-3 integraseMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273903(CHEMBL4129717)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273964(CHEMBL4130252)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273916(CHEMBL4126289)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273952(CHEMBL4130102)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273915(CHEMBL4127891)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273965(CHEMBL4127923)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273948(CHEMBL4127873)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 2)
Wuhan University Of Technology

Curated by ChEMBL
LigandPNGBDBM50062551(CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572)
Affinity DataEC50:  2.30nMAssay Description:Inhibition of wild type HIV-2 ROD9 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273902(CHEMBL4126659)
Affinity DataEC50:  3nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273949(CHEMBL4128924)
Affinity DataEC50:  3nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273963(CHEMBL4128890)
Affinity DataEC50:  3nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273953(CHEMBL4126840)
Affinity DataEC50:  3nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273964(CHEMBL4130252)
Affinity DataEC50:  3nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50062551(CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572)
Affinity DataEC50:  3.60nMAssay Description:Inhibition of HIV-1 NL4-3 integrase E92Q/N155H double mutantMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273951(CHEMBL4126165)
Affinity DataEC50:  5nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273963(CHEMBL4128890)
Affinity DataEC50:  6nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50062551(CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572)
Affinity DataEC50:  6.80nMAssay Description:Inhibition of HIV-1 NL4-3 integrase G140S/Q148R double mutantMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273952(CHEMBL4130102)
Affinity DataEC50:  7nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273950(CHEMBL4128240)
Affinity DataEC50:  8nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273953(CHEMBL4126840)
Affinity DataEC50:  12nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273949(CHEMBL4128924)
Affinity DataEC50:  14nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273916(CHEMBL4126289)
Affinity DataEC50:  17nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273965(CHEMBL4127923)
Affinity DataEC50:  19nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273903(CHEMBL4129717)
Affinity DataEC50:  19nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273948(CHEMBL4127873)
Affinity DataEC50:  21nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273914(CHEMBL4126686)
Affinity DataEC50:  21nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273916(CHEMBL4126289)
Affinity DataEC50:  25nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 40% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50467945(CHEMBL4291455)
Affinity DataEC50:  27nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273902(CHEMBL4126659)
Affinity DataEC50:  27nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273904(CHEMBL4128715)
Affinity DataEC50:  53nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50500143(CHEMBL3747158)
Affinity DataEC50:  69nMAssay Description:Antiviral activity against HIV1 assessed as inhibition of integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50498473(CHEMBL1230654)
Affinity DataEC50:  69nMAssay Description:Antiviral activity against HIV1 assessed as inhibition of integraseMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataEC50:  70nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50467949(CHEMBL4293273)
Affinity DataEC50:  80nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273915(CHEMBL4127891)
Affinity DataEC50:  84nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273913(CHEMBL4127663)
Affinity DataEC50:  90nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50467960(CHEMBL4289412)
Affinity DataEC50:  100nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50123468(CHEMBL32865 | [3-Benzyl-5-(1,1-dioxo-1lambda 6 -is...)
Affinity DataEC50:  140nMAssay Description:Potency of compound was tested against HIV-1- containing integrase mutations (NL4-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataEC50:  146nMAssay Description:Induction of HIV1 His/FLAG-tagged integrase hyper-multimerization expressed in Escherichia coli BL21(DE3) by HTRF assayMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273951(CHEMBL4126165)
Affinity DataEC50:  149nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50467958(CHEMBL4293230)
Affinity DataEC50:  230nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50467947(CHEMBL4279717)
Affinity DataEC50:  240nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50467942(CHEMBL4292417)
Affinity DataEC50:  260nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50467940(CHEMBL4294452)
Affinity DataEC50:  350nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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