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Compile Data Set for Download or QSAR

Found 328 hits Enz. Inhib. hit(s) with Target = 'Liver Receptor Homolog 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22376
PNG
((3aS,6aR)-4-cyclohexyl-5-[(4E)-oct-4-en-4-yl]-N-ph...)
Show SMILES CCC\C=C(/CCC)C1=C(C2CCCCC2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C28H41N/c1-3-5-14-22(13-4-2)26-21-24-17-12-20-28(24,29-25-18-10-7-11-19-25)27(26)23-15-8-6-9-16-23/h7,10-11,14,18-19,23-24,29H,3-6,8-9,12-13,15-17,20-21H2,1-2H3/b22-14+/t24-,28+/m1/s1
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n/an/an/an/a 12n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


J Med Chem 49: 6652-5 (2006)


Article DOI: 10.1021/jm060990k
BindingDB Entry DOI: 10.7270/Q2930RGT
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50505369
PNG
(CHEMBL4440757)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](NS(N)(=O)=O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H36N2O2S/c1-3-4-5-8-17-24-20-25-26(30-33(29,31)32)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,30H,2-5,8,17-20H2,1H3,(H2,29,31,32)/t25-,26-,28-/m0/s1
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n/an/an/an/a 15n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay


J Med Chem 62: 11022-11034 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00753
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22375
PNG
((3aS,6aR)-4-butyl-5-[(4E)-oct-4-en-4-yl]-N-phenyl-...)
Show SMILES CCCCC1=C(C[C@H]2CCC[C@@]12Nc1ccccc1)C(\CCC)=C\CCC
Show InChI InChI=1S/C26H39N/c1-4-7-14-21(13-6-3)24-20-22-15-12-19-26(22,25(24)18-8-5-2)27-23-16-10-9-11-17-23/h9-11,14,16-17,22,27H,4-8,12-13,15,18-20H2,1-3H3/b21-14+/t22-,26+/m1/s1
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n/an/an/an/a 22n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


J Med Chem 49: 6652-5 (2006)


Article DOI: 10.1021/jm060990k
BindingDB Entry DOI: 10.7270/Q2930RGT
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22391
PNG
((3aS,6aR)-N-(2,3-dimethylphenyl)-5-hexyl-4-phenyl-...)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1cccc(C)c1C
Show InChI InChI=1S/C28H37N/c1-4-5-6-8-16-24-20-25-17-12-19-28(25,27(24)23-14-9-7-10-15-23)29-26-18-11-13-21(2)22(26)3/h7,9-11,13-15,18,25,29H,4-6,8,12,16-17,19-20H2,1-3H3/t25-,28+/m1/s1
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n/an/an/an/a 30n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


J Med Chem 49: 6652-5 (2006)


Article DOI: 10.1021/jm060990k
BindingDB Entry DOI: 10.7270/Q2930RGT
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22385
PNG
((3aS,6aR)-5-hexyl-N,4-diphenyl-1,2,3,3a,6,6a-hexah...)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C26H33N/c1-2-3-4-7-15-22-20-23-16-12-19-26(23,27-24-17-10-6-11-18-24)25(22)21-13-8-5-9-14-21/h5-6,8-11,13-14,17-18,23,27H,2-4,7,12,15-16,19-20H2,1H3/t23-,26+/m1/s1
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n/an/an/an/a 31.6n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22385
PNG
((3aS,6aR)-5-hexyl-N,4-diphenyl-1,2,3,3a,6,6a-hexah...)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C26H33N/c1-2-3-4-7-15-22-20-23-16-12-19-26(23,27-24-17-10-6-11-18-24)25(22)21-13-8-5-9-14-21/h5-6,8-11,13-14,17-18,23,27H,2-4,7,12,15-16,19-20H2,1H3/t23-,26+/m1/s1
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n/an/an/an/a 34n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


J Med Chem 49: 6652-5 (2006)


Article DOI: 10.1021/jm060990k
BindingDB Entry DOI: 10.7270/Q2930RGT
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50505372
PNG
(CHEMBL4447391)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](NS(N)(=O)=O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H36N2O2S/c1-3-4-5-8-17-24-20-25-26(30-33(29,31)32)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,30H,2-5,8,17-20H2,1H3,(H2,29,31,32)/t25-,26+,28-/m0/s1
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n/an/an/an/a 40n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay


J Med Chem 62: 11022-11034 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00753
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22379
PNG
((3aS,6aR)-4-(naphthalen-2-yl)-5-[(4E)-oct-4-en-4-y...)
Show SMILES CCC\C=C(/CCC)C1=C(c2ccc3ccccc3c2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C32H37N/c1-3-5-13-25(12-4-2)30-23-28-16-11-21-32(28,33-29-17-7-6-8-18-29)31(30)27-20-19-24-14-9-10-15-26(24)22-27/h6-10,13-15,17-20,22,28,33H,3-5,11-12,16,21,23H2,1-2H3/b25-13+/t28-,32+/m1/s1
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n/an/an/an/a 60n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


J Med Chem 49: 6652-5 (2006)


Article DOI: 10.1021/jm060990k
BindingDB Entry DOI: 10.7270/Q2930RGT
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22382
PNG
((3aS,6aR)-5-(hexan-2-yl)-N,4-diphenyl-1,2,3,3a,6,6...)
Show SMILES CCCCC(C)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C26H33N/c1-3-4-12-20(2)24-19-22-15-11-18-26(22,27-23-16-9-6-10-17-23)25(24)21-13-7-5-8-14-21/h5-10,13-14,16-17,20,22,27H,3-4,11-12,15,18-19H2,1-2H3/t20?,22-,26+/m1/s1
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n/an/an/an/a 70n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


J Med Chem 49: 6652-5 (2006)


Article DOI: 10.1021/jm060990k
BindingDB Entry DOI: 10.7270/Q2930RGT
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22374
PNG
((3aS,6aR)-4-methyl-5-[(4E)-oct-4-en-4-yl]-N-phenyl...)
Show SMILES CCC\C=C(/CCC)C1=C(C)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C23H33N/c1-4-6-12-19(11-5-2)22-17-20-13-10-16-23(20,18(22)3)24-21-14-8-7-9-15-21/h7-9,12,14-15,20,24H,4-6,10-11,13,16-17H2,1-3H3/b19-12+/t20-,23-/m1/s1
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n/an/an/an/a 90n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


J Med Chem 49: 6652-5 (2006)


Article DOI: 10.1021/jm060990k
BindingDB Entry DOI: 10.7270/Q2930RGT
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50505367
PNG
(CHEMBL4565513)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](OS(=O)(=O)NC(N)=O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C29H36N2O4S/c1-3-4-5-8-17-24-20-25-26(35-36(33,34)31-28(30)32)18-19-29(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26H,2-5,8,17-20H2,1H3,(H3,30,31,32)/t25-,26-,29-/m0/s1
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n/an/an/an/a 100n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay


J Med Chem 62: 11022-11034 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00753
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418312
PNG
(CHEMBL1765932)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)OCc1ccccc1
Show InChI InChI=1S/C27H34O/c1-2-3-4-9-17-24-20-25-18-12-19-27(25,26(24)23-15-10-6-11-16-23)28-21-22-13-7-5-8-14-22/h5-8,10-11,13-16,25H,2-4,9,12,17-21H2,1H3/t25-,27+/m1/s1
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n/an/an/an/a 100n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22378
PNG
((3aS,6aR)-4-(3-methoxyphenyl)-5-[(4E)-oct-4-en-4-y...)
Show SMILES CCC\C=C(/CCC)C1=C(c2cccc(OC)c2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C29H37NO/c1-4-6-13-22(12-5-2)27-21-24-15-11-19-29(24,30-25-16-8-7-9-17-25)28(27)23-14-10-18-26(20-23)31-3/h7-10,13-14,16-18,20,24,30H,4-6,11-12,15,19,21H2,1-3H3/b22-13+/t24-,29+/m1/s1
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n/an/an/an/a 100n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


J Med Chem 49: 6652-5 (2006)


Article DOI: 10.1021/jm060990k
BindingDB Entry DOI: 10.7270/Q2930RGT
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22388
PNG
((3aS,6aR)-N,4,5-triphenyl-1,2,3,3a,6,6a-hexahydrop...)
Show SMILES C1C[C@@H]2CC(=C(c3ccccc3)[C@@]2(C1)Nc1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H25N/c1-4-11-20(12-5-1)24-19-22-15-10-18-26(22,27-23-16-8-3-9-17-23)25(24)21-13-6-2-7-14-21/h1-9,11-14,16-17,22,27H,10,15,18-19H2/t22-,26+/m1/s1
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n/an/an/an/a 150n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


J Med Chem 49: 6652-5 (2006)


Article DOI: 10.1021/jm060990k
BindingDB Entry DOI: 10.7270/Q2930RGT
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418306
PNG
(CHEMBL1765955)
Show SMILES C[Si](C)(C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H32Si/c1-23(24-14-7-4-8-15-24)30-21-13-18-26(30)22-28(29(30)25-16-9-5-10-17-25)31(2,3)27-19-11-6-12-20-27/h4-12,14-17,19-20,26H,1,13,18,21-22H2,2-3H3/t26-,30+/m1/s1
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n/an/an/an/a 158n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22377
PNG
((3aS,6aR)-4-(4-bromophenyl)-5-[(4E)-oct-4-en-4-yl]...)
Show SMILES CCC\C=C(/CCC)C1=C(c2ccc(Br)cc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C28H34BrN/c1-3-5-11-21(10-4-2)26-20-23-12-9-19-28(23,30-25-13-7-6-8-14-25)27(26)22-15-17-24(29)18-16-22/h6-8,11,13-18,23,30H,3-5,9-10,12,19-20H2,1-2H3/b21-11+/t23-,28+/m1/s1
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n/an/an/an/a 160n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


J Med Chem 49: 6652-5 (2006)


Article DOI: 10.1021/jm060990k
BindingDB Entry DOI: 10.7270/Q2930RGT
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418304
PNG
(CHEMBL1765953)
Show SMILES CCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C26H30/c1-3-4-12-23-19-24-17-11-18-26(24,20(2)21-13-7-5-8-14-21)25(23)22-15-9-6-10-16-22/h5-10,13-16,24H,2-4,11-12,17-19H2,1H3/t24-,26+/m1/s1
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n/an/an/an/a 200n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22386
PNG
((3aS,6aR)-5-cyclohexyl-N,4-diphenyl-1,2,3,3a,6,6a-...)
Show SMILES C1C[C@@H]2CC(C3CCCCC3)=C(c3ccccc3)[C@@]2(C1)Nc1ccccc1
Show InChI InChI=1S/C26H31N/c1-4-11-20(12-5-1)24-19-22-15-10-18-26(22,27-23-16-8-3-9-17-23)25(24)21-13-6-2-7-14-21/h2-3,6-9,13-14,16-17,20,22,27H,1,4-5,10-12,15,18-19H2/t22-,26+/m1/s1
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n/an/an/an/a 230n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


J Med Chem 49: 6652-5 (2006)


Article DOI: 10.1021/jm060990k
BindingDB Entry DOI: 10.7270/Q2930RGT
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418309
PNG
(CHEMBL1765956)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C29H36/c1-3-4-5-8-19-26-22-27-20-13-14-21-29(27,23(2)24-15-9-6-10-16-24)28(26)25-17-11-7-12-18-25/h6-7,9-12,15-18,27H,2-5,8,13-14,19-22H2,1H3/t27-,29+/m1/s1
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n/an/an/an/a 251n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418310
PNG
(CHEMBL1765962)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](OC(C)=O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C30H36O2/c1-4-5-6-9-18-26-21-27-28(32-23(3)31)19-20-30(27,22(2)24-14-10-7-11-15-24)29(26)25-16-12-8-13-17-25/h7-8,10-17,27-28H,2,4-6,9,18-21H2,1,3H3/t27-,28-,30-/m0/s1
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n/an/an/an/a 251n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418308
PNG
(CHEMBL1765933)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H34/c1-3-4-5-8-18-25-21-26-19-13-20-28(26,22(2)23-14-9-6-10-15-23)27(25)24-16-11-7-12-17-24/h6-7,9-12,14-17,26H,2-5,8,13,18-21H2,1H3/t26-,28+/m1/s1
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n/an/an/an/a 251n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418313
PNG
(CHEMBL1765945)
Show SMILES CCCCCCC1=C(c2cccc(OC)c2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C29H36O/c1-4-5-6-8-15-24-20-26-17-12-19-29(26,22(2)23-13-9-7-10-14-23)28(24)25-16-11-18-27(21-25)30-3/h7,9-11,13-14,16,18,21,26H,2,4-6,8,12,15,17,19-20H2,1,3H3/t26-,29+/m1/s1
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n/an/an/an/a 251n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418303
PNG
(CHEMBL1765959)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-20-25-26(29)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26+,28-/m0/s1
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n/an/an/an/a 251n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418307
PNG
(CHEMBL1765934)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1cccc(OC)c1
Show InChI InChI=1S/C29H36O/c1-4-5-6-8-15-25-20-26-17-12-19-29(26,28(25)23-13-9-7-10-14-23)22(2)24-16-11-18-27(21-24)30-3/h7,9-11,13-14,16,18,21,26H,2,4-6,8,12,15,17,19-20H2,1,3H3/t26-,29+/m1/s1
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n/an/an/an/a 316n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418325
PNG
(CHEMBL1765958)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CN(Cc3ccccc3)C[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C34H39N/c1-3-4-5-11-22-31-23-32-25-35(24-28-16-9-6-10-17-28)26-34(32,27(2)29-18-12-7-13-19-29)33(31)30-20-14-8-15-21-30/h6-10,12-21,32H,2-5,11,22-26H2,1H3/t32-,34-/m0/s1
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n/an/an/an/a 316n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22383
PNG
((3aS,6aR)-5-(decan-2-yl)-N,4-diphenyl-1,2,3,3a,6,6...)
Show SMILES CCCCCCCCC(C)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C30H41N/c1-3-4-5-6-7-10-16-24(2)28-23-26-19-15-22-30(26,31-27-20-13-9-14-21-27)29(28)25-17-11-8-12-18-25/h8-9,11-14,17-18,20-21,24,26,31H,3-7,10,15-16,19,22-23H2,1-2H3/t24?,26-,30+/m1/s1
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n/an/an/an/a 320n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


J Med Chem 49: 6652-5 (2006)


Article DOI: 10.1021/jm060990k
BindingDB Entry DOI: 10.7270/Q2930RGT
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22389
PNG
((3aS,6aR)-N-(3-fluorophenyl)-5-hexyl-4-phenyl-1,2,...)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1cccc(F)c1
Show InChI InChI=1S/C26H32FN/c1-2-3-4-6-13-21-18-22-14-10-17-26(22,25(21)20-11-7-5-8-12-20)28-24-16-9-15-23(27)19-24/h5,7-9,11-12,15-16,19,22,28H,2-4,6,10,13-14,17-18H2,1H3/t22-,26+/m1/s1
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n/an/an/an/a 330n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


J Med Chem 49: 6652-5 (2006)


Article DOI: 10.1021/jm060990k
BindingDB Entry DOI: 10.7270/Q2930RGT
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418305
PNG
(CHEMBL1765960)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-20-25-26(29)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26-,28-/m0/s1
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n/an/an/an/a 398n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418326
PNG
(CHEMBL1765961)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](OC(C)=O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C30H36O2/c1-4-5-6-9-18-26-21-27-28(32-23(3)31)19-20-30(27,22(2)24-14-10-7-11-15-24)29(26)25-16-12-8-13-17-25/h7-8,10-17,27-28H,2,4-6,9,18-21H2,1,3H3/t27-,28+,30-/m0/s1
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n/an/an/an/a 398n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50468000
PNG
(CHEMBL4288251)
Show SMILES O[C@@H]1CC[C@@]2([C@H]1CC(CCCCCCCCCC(O)=O)=C2c1ccccc1)C(=C)c1ccccc1
Show InChI InChI=1S/C32H40O3/c1-24(25-15-10-7-11-16-25)32-22-21-29(33)28(32)23-27(31(32)26-17-12-8-13-18-26)19-9-5-3-2-4-6-14-20-30(34)35/h7-8,10-13,15-18,28-29,33H,1-6,9,14,19-23H2,(H,34,35)/t28-,29+,32-/m0/s1
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n/an/an/an/a 400n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Agonist activity at recombinant full length human LRH1 expressed in HeLa cells after 24 hrs by dual-glo luciferase reporter gene assay


ACS Med Chem Lett 9: 1051-1056 (2018)


Article DOI: 10.1021/acsmedchemlett.8b00361
BindingDB Entry DOI: 10.7270/Q2WW7MCP
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22373
PNG
((3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-1,2,...)
Show SMILES CCC\C=C(/CCC)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C28H35N/c1-3-5-14-22(13-4-2)26-21-24-17-12-20-28(24,29-25-18-10-7-11-19-25)27(26)23-15-8-6-9-16-23/h6-11,14-16,18-19,24,29H,3-5,12-13,17,20-21H2,1-2H3/b22-14+/t24-,28+/m1/s1
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n/an/an/an/a 430n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


J Med Chem 49: 6652-5 (2006)


Article DOI: 10.1021/jm060990k
BindingDB Entry DOI: 10.7270/Q2930RGT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50505380
PNG
(CHEMBL4541939)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](NC(N)=O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C29H36N2O/c1-3-4-5-8-17-24-20-25-26(31-28(30)32)18-19-29(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26H,2-5,8,17-20H2,1H3,(H3,30,31,32)/t25-,26-,29-/m0/s1
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n/an/an/an/a 500n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay


J Med Chem 62: 11022-11034 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00753
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418316
PNG
(CHEMBL1765966)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(C[C@@H](C[C@@H]2C1)OC(C)=O)C(=C)c1ccccc1
Show InChI InChI=1S/C30H36O2/c1-4-5-6-9-18-26-19-27-20-28(32-23(3)31)21-30(27,22(2)24-14-10-7-11-15-24)29(26)25-16-12-8-13-17-25/h7-8,10-17,27-28H,2,4-6,9,18-21H2,1,3H3/t27-,28+,30-/m0/s1
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n/an/an/an/a 501n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50505376
PNG
(CHEMBL4461328)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](OS(N)(=O)=O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H35NO3S/c1-3-4-5-8-17-24-20-25-26(32-33(29,30)31)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26H,2-5,8,17-20H2,1H3,(H2,29,30,31)/t25-,26-,28-/m0/s1
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n/an/an/an/a 600n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human LRH1 ligand binding domain (300 to 537 residues) expressed in Escherichia coli BL21 cells assessed as increase ...


J Med Chem 62: 11022-11034 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00753
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418303
PNG
(CHEMBL1765959)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-20-25-26(29)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26+,28-/m0/s1
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n/an/an/an/a 600n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human LRH1 ligand binding domain (300 to 537 residues) expressed in Escherichia coli BL21 cells assessed as increase ...


J Med Chem 62: 11022-11034 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00753
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50505369
PNG
(CHEMBL4440757)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](NS(N)(=O)=O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H36N2O2S/c1-3-4-5-8-17-24-20-25-26(30-33(29,31)32)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,30H,2-5,8,17-20H2,1H3,(H2,29,31,32)/t25-,26-,28-/m0/s1
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n/an/an/an/a 600n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human LRH1 ligand binding domain (300 to 537 residues) expressed in Escherichia coli BL21 cells assessed as increase ...


J Med Chem 62: 11022-11034 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00753
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22373
PNG
((3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-1,2,...)
Show SMILES CCC\C=C(/CCC)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C28H35N/c1-3-5-14-22(13-4-2)26-21-24-17-12-20-28(24,29-25-18-10-7-11-19-25)27(26)23-15-8-6-9-16-23/h6-11,14-16,18-19,24,29H,3-5,12-13,17,20-21H2,1-2H3/b22-14+/t24-,28+/m1/s1
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n/an/an/an/a 631n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418329
PNG
(CHEMBL1765951)
Show SMILES CCCCCCC1=C(CCCO)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C25H36O/c1-3-4-5-7-14-22-19-23-15-10-17-25(23,24(22)16-11-18-26)20(2)21-12-8-6-9-13-21/h6,8-9,12-13,23,26H,2-5,7,10-11,14-19H2,1H3/t23-,25+/m1/s1
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n/an/an/an/a 794n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418311
PNG
(CHEMBL1765931)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)OC1CCCCC1
Show InChI InChI=1S/C26H38O/c1-2-3-4-7-15-22-20-23-16-12-19-26(23,27-24-17-10-6-11-18-24)25(22)21-13-8-5-9-14-21/h5,8-9,13-14,23-24H,2-4,6-7,10-12,15-20H2,1H3/t23-,26+/m1/s1
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n/an/an/an/a 794n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50505371
PNG
(CHEMBL4455426)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](OS(N)(=O)=O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H35NO3S/c1-3-4-5-8-17-24-20-25-26(32-33(29,30)31)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26H,2-5,8,17-20H2,1H3,(H2,29,30,31)/t25-,26+,28-/m0/s1
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n/an/an/an/a 800n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay


J Med Chem 62: 11022-11034 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00753
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50505378
PNG
(CHEMBL4558553)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](O)[C@@H]2C1)C(=C)Cc1ccccc1
Show InChI InChI=1S/C29H36O/c1-3-4-5-10-17-25-21-26-27(30)18-19-29(26,28(25)24-15-11-7-12-16-24)22(2)20-23-13-8-6-9-14-23/h6-9,11-16,26-27,30H,2-5,10,17-21H2,1H3/t26-,27+,29-/m0/s1
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n/an/an/an/a 800n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay


J Med Chem 62: 11022-11034 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00753
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50505366
PNG
(CHEMBL4452061)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](O)[C@@H]2C1)C(=C)c1ccccc1C
Show InChI InChI=1S/C29H36O/c1-4-5-6-8-16-24-20-26-27(30)18-19-29(26,28(24)23-14-9-7-10-15-23)22(3)25-17-12-11-13-21(25)2/h7,9-15,17,26-27,30H,3-6,8,16,18-20H2,1-2H3/t26-,27+,29-/m0/s1
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n/an/an/an/a 900n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay


J Med Chem 62: 11022-11034 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00753
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50505376
PNG
(CHEMBL4461328)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](OS(N)(=O)=O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H35NO3S/c1-3-4-5-8-17-24-20-25-26(32-33(29,30)31)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26H,2-5,8,17-20H2,1H3,(H2,29,30,31)/t25-,26-,28-/m0/s1
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n/an/an/an/a 900n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay


J Med Chem 62: 11022-11034 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00753
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22390
PNG
((3aS,6aR)-N-(4-chlorophenyl)-5-hexyl-4-phenyl-1,2,...)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C26H32ClN/c1-2-3-4-6-12-21-19-22-13-9-18-26(22,25(21)20-10-7-5-8-11-20)28-24-16-14-23(27)15-17-24/h5,7-8,10-11,14-17,22,28H,2-4,6,9,12-13,18-19H2,1H3/t22-,26+/m1/s1
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n/an/an/an/a 1.00E+3n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


J Med Chem 49: 6652-5 (2006)


Article DOI: 10.1021/jm060990k
BindingDB Entry DOI: 10.7270/Q2930RGT
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418321
PNG
(CHEMBL1765963)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(C[C@@H](O)C[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-18-25-19-26(29)20-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26-,28-/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418330
PNG
(CHEMBL1765938)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccc(CCCC)cc1
Show InChI InChI=1S/C32H42/c1-4-6-8-10-17-29-24-30-18-13-23-32(30,31(29)28-15-11-9-12-16-28)25(3)27-21-19-26(20-22-27)14-7-5-2/h9,11-12,15-16,19-22,30H,3-8,10,13-14,17-18,23-24H2,1-2H3/t30-,32+/m1/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50505370
PNG
(CHEMBL4460749)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H]([C@@H]2C1)n1ccnn1)C(=C)c1ccccc1
Show InChI InChI=1S/C30H35N3/c1-3-4-5-8-17-26-22-27-28(33-21-20-31-32-33)18-19-30(27,23(2)24-13-9-6-10-14-24)29(26)25-15-11-7-12-16-25/h6-7,9-16,20-21,27-28H,2-5,8,17-19,22H2,1H3/t27-,28-,30-/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay


J Med Chem 62: 11022-11034 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00753
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418303
PNG
(CHEMBL1765959)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-20-25-26(29)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26+,28-/m0/s1
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n/an/an/an/a 1.10E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Agonist activity at recombinant full length human LRH1 expressed in HeLa cells after 24 hrs by dual-glo luciferase reporter gene assay


ACS Med Chem Lett 9: 1051-1056 (2018)


Article DOI: 10.1021/acsmedchemlett.8b00361
BindingDB Entry DOI: 10.7270/Q2WW7MCP
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM22395
PNG
(N-[(3aS,6aR)-5-hexyl-4-phenyl-1,2,3,3a,6,6a-hexahy...)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1cccc2ccccc12
Show InChI InChI=1S/C30H35N/c1-2-3-4-6-16-25-22-26-18-12-21-30(26,29(25)24-14-7-5-8-15-24)31-28-20-11-17-23-13-9-10-19-27(23)28/h5,7-11,13-15,17,19-20,26,31H,2-4,6,12,16,18,21-22H2,1H3/t26-,30+/m1/s1
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n/an/an/an/a 1.20E+3n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


J Med Chem 49: 6652-5 (2006)


Article DOI: 10.1021/jm060990k
BindingDB Entry DOI: 10.7270/Q2930RGT
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (Human))
BDBM50418317
PNG
(CHEMBL1765950)
Show SMILES CCCCCCC1=C(C2CCCCC2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H40/c1-3-4-5-8-18-25-21-26-19-13-20-28(26,22(2)23-14-9-6-10-15-23)27(25)24-16-11-7-12-17-24/h6,9-10,14-15,24,26H,2-5,7-8,11-13,16-21H2,1H3/t26-,28+/m1/s1
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n/an/an/an/a 1.26E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)


Article DOI: 10.1021/jm1014296
BindingDB Entry DOI: 10.7270/Q29Z957P
More data for this
Ligand-Target Pair
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