Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22376![]() ((3aS,6aR)-4-cyclohexyl-5-[(4E)-oct-4-en-4-yl]-N-ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 12 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50505369![]() (CHEMBL4440757) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22375![]() ((3aS,6aR)-4-butyl-5-[(4E)-oct-4-en-4-yl]-N-phenyl-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 22 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22391![]() ((3aS,6aR)-N-(2,3-dimethylphenyl)-5-hexyl-4-phenyl-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 30 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22385![]() ((3aS,6aR)-5-hexyl-N,4-diphenyl-1,2,3,3a,6,6a-hexah...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 31.6 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22385![]() ((3aS,6aR)-5-hexyl-N,4-diphenyl-1,2,3,3a,6,6a-hexah...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 34 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50505372![]() (CHEMBL4447391) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22379![]() ((3aS,6aR)-4-(naphthalen-2-yl)-5-[(4E)-oct-4-en-4-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 60 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22382![]() ((3aS,6aR)-5-(hexan-2-yl)-N,4-diphenyl-1,2,3,3a,6,6...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 70 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22374![]() ((3aS,6aR)-4-methyl-5-[(4E)-oct-4-en-4-yl]-N-phenyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 90 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50505367![]() (CHEMBL4565513) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418312![]() (CHEMBL1765932) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22378![]() ((3aS,6aR)-4-(3-methoxyphenyl)-5-[(4E)-oct-4-en-4-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 100 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22388![]() ((3aS,6aR)-N,4,5-triphenyl-1,2,3,3a,6,6a-hexahydrop...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 150 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418306![]() (CHEMBL1765955) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 158 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22377![]() ((3aS,6aR)-4-(4-bromophenyl)-5-[(4E)-oct-4-en-4-yl]...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 160 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418304![]() (CHEMBL1765953) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22386![]() ((3aS,6aR)-5-cyclohexyl-N,4-diphenyl-1,2,3,3a,6,6a-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 230 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418309![]() (CHEMBL1765956) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 251 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418310![]() (CHEMBL1765962) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 251 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418308![]() (CHEMBL1765933) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 251 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418313![]() (CHEMBL1765945) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 251 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418303![]() (CHEMBL1765959) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 251 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418307![]() (CHEMBL1765934) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 316 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418325![]() (CHEMBL1765958) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 316 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22383![]() ((3aS,6aR)-5-(decan-2-yl)-N,4-diphenyl-1,2,3,3a,6,6...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 320 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22389![]() ((3aS,6aR)-N-(3-fluorophenyl)-5-hexyl-4-phenyl-1,2,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 330 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418305![]() (CHEMBL1765960) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 398 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418326![]() (CHEMBL1765961) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 398 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50468000![]() (CHEMBL4288251) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 400 | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Agonist activity at recombinant full length human LRH1 expressed in HeLa cells after 24 hrs by dual-glo luciferase reporter gene assay | ACS Med Chem Lett 9: 1051-1056 (2018) Article DOI: 10.1021/acsmedchemlett.8b00361 BindingDB Entry DOI: 10.7270/Q2WW7MCP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22373![]() ((3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-1,2,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | n/a | 430 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50505380![]() (CHEMBL4541939) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 500 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418316![]() (CHEMBL1765966) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 501 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50505376![]() (CHEMBL4461328) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | 600 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at recombinant human LRH1 ligand binding domain (300 to 537 residues) expressed in Escherichia coli BL21 cells assessed as increase ... | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418303![]() (CHEMBL1765959) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 600 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at recombinant human LRH1 ligand binding domain (300 to 537 residues) expressed in Escherichia coli BL21 cells assessed as increase ... | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50505369![]() (CHEMBL4440757) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | 600 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at recombinant human LRH1 ligand binding domain (300 to 537 residues) expressed in Escherichia coli BL21 cells assessed as increase ... | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22373![]() ((3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-1,2,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | n/a | 631 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418329![]() (CHEMBL1765951) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 794 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418311![]() (CHEMBL1765931) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 794 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50505371![]() (CHEMBL4455426) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 800 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50505378![]() (CHEMBL4558553) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 800 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50505366![]() (CHEMBL4452061) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 900 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50505376![]() (CHEMBL4461328) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | 900 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22390![]() ((3aS,6aR)-N-(4-chlorophenyl)-5-hexyl-4-phenyl-1,2,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418321![]() (CHEMBL1765963) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418330![]() (CHEMBL1765938) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50505370![]() (CHEMBL4460749) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418303![]() (CHEMBL1765959) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Agonist activity at recombinant full length human LRH1 expressed in HeLa cells after 24 hrs by dual-glo luciferase reporter gene assay | ACS Med Chem Lett 9: 1051-1056 (2018) Article DOI: 10.1021/acsmedchemlett.8b00361 BindingDB Entry DOI: 10.7270/Q2WW7MCP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM22395![]() (N-[(3aS,6aR)-5-hexyl-4-phenyl-1,2,3,3a,6,6a-hexahy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver Receptor Homolog 1 (Homo sapiens (Human)) | BDBM50418317![]() (CHEMBL1765950) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair |
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