Compile Data Set for Download or QSAR

Found 328 hits Enz. Inhib. hit(s) with Target = 'Liver Receptor Homolog 1'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22376 ((3aS,6aR)-4-cyclohexyl-5-[(4E)-oct-4-en-4-yl]-N-ph...) Show SMILES CCC\C=C(/CCC)C1=C(C2CCCCC2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1 Show InChI InChI=1S/C28H41N/c1-3-5-14-22(13-4-2)26-21-24-17-12-20-28(24,29-25-18-10-7-11-19-25)27(26)23-15-8-6-9-16-23/h7,10-11,14,18-19,23-24,29H,3-6,8-9,12-13,15-17,20-21H2,1-2H3/b22-14+/t24-,28+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	12	n/a	n/a	7.5	22
University of Southampton					Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...				J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50505369 (CHEMBL4440757) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](NS(N)(=O)=O)[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C28H36N2O2S/c1-3-4-5-8-17-24-20-25-26(30-33(29,31)32)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,30H,2-5,8,17-20H2,1H3,(H2,29,31,32)/t25-,26-,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay				J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753
					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22375 ((3aS,6aR)-4-butyl-5-[(4E)-oct-4-en-4-yl]-N-phenyl-...) Show SMILES CCCCC1=C(C[C@H]2CCC[C@@]12Nc1ccccc1)C(\CCC)=C\CCC Show InChI InChI=1S/C26H39N/c1-4-7-14-21(13-6-3)24-20-22-15-12-19-26(22,25(24)18-8-5-2)27-23-16-10-9-11-17-23/h9-11,14,16-17,22,27H,4-8,12-13,15,18-20H2,1-3H3/b21-14+/t22-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	22	n/a	n/a	7.5	22
University of Southampton					Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...				J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22391 ((3aS,6aR)-N-(2,3-dimethylphenyl)-5-hexyl-4-phenyl-...) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1cccc(C)c1C Show InChI InChI=1S/C28H37N/c1-4-5-6-8-16-24-20-25-17-12-19-28(25,27(24)23-14-9-7-10-15-23)29-26-18-11-13-21(2)22(26)3/h7,9-11,13-15,18,25,29H,4-6,8,12,16-17,19-20H2,1-3H3/t25-,28+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	7.5	22
University of Southampton					Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...				J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22385 ((3aS,6aR)-5-hexyl-N,4-diphenyl-1,2,3,3a,6,6a-hexah...) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1 Show InChI InChI=1S/C26H33N/c1-2-3-4-7-15-22-20-23-16-12-19-26(23,27-24-17-10-6-11-18-24)25(22)21-13-8-5-9-14-21/h5-6,8-11,13-14,17-18,23,27H,2-4,7,12,15-16,19-20H2,1H3/t23-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	31.6	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22385 ((3aS,6aR)-5-hexyl-N,4-diphenyl-1,2,3,3a,6,6a-hexah...) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1 Show InChI InChI=1S/C26H33N/c1-2-3-4-7-15-22-20-23-16-12-19-26(23,27-24-17-10-6-11-18-24)25(22)21-13-8-5-9-14-21/h5-6,8-11,13-14,17-18,23,27H,2-4,7,12,15-16,19-20H2,1H3/t23-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	34	n/a	n/a	7.5	22
University of Southampton					Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...				J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50505372 (CHEMBL4447391) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](NS(N)(=O)=O)[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C28H36N2O2S/c1-3-4-5-8-17-24-20-25-26(30-33(29,31)32)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,30H,2-5,8,17-20H2,1H3,(H2,29,31,32)/t25-,26+,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay				J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22379 ((3aS,6aR)-4-(naphthalen-2-yl)-5-[(4E)-oct-4-en-4-y...) Show SMILES CCC\C=C(/CCC)C1=C(c2ccc3ccccc3c2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1 Show InChI InChI=1S/C32H37N/c1-3-5-13-25(12-4-2)30-23-28-16-11-21-32(28,33-29-17-7-6-8-18-29)31(30)27-20-19-24-14-9-10-15-26(24)22-27/h6-10,13-15,17-20,22,28,33H,3-5,11-12,16,21,23H2,1-2H3/b25-13+/t28-,32+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	7.5	22
University of Southampton					Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...				J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22382 ((3aS,6aR)-5-(hexan-2-yl)-N,4-diphenyl-1,2,3,3a,6,6...) Show SMILES CCCCC(C)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1 Show InChI InChI=1S/C26H33N/c1-3-4-12-20(2)24-19-22-15-11-18-26(22,27-23-16-9-6-10-17-23)25(24)21-13-7-5-8-14-21/h5-10,13-14,16-17,20,22,27H,3-4,11-12,15,18-19H2,1-2H3/t20?,22-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	70	n/a	n/a	7.5	22
University of Southampton					Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...				J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22374 ((3aS,6aR)-4-methyl-5-[(4E)-oct-4-en-4-yl]-N-phenyl...) Show SMILES CCC\C=C(/CCC)C1=C(C)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1 Show InChI InChI=1S/C23H33N/c1-4-6-12-19(11-5-2)22-17-20-13-10-16-23(20,18(22)3)24-21-14-8-7-9-15-21/h7-9,12,14-15,20,24H,4-6,10-11,13,16-17H2,1-3H3/b19-12+/t20-,23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	90	n/a	n/a	7.5	22
University of Southampton					Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...				J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50505367 (CHEMBL4565513) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](OS(=O)(=O)NC(N)=O)[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C29H36N2O4S/c1-3-4-5-8-17-24-20-25-26(35-36(33,34)31-28(30)32)18-19-29(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26H,2-5,8,17-20H2,1H3,(H3,30,31,32)/t25-,26-,29-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay				J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418312 (CHEMBL1765932) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)OCc1ccccc1 Show InChI InChI=1S/C27H34O/c1-2-3-4-9-17-24-20-25-18-12-19-27(25,26(24)23-15-10-6-11-16-23)28-21-22-13-7-5-8-14-22/h5-8,10-11,13-16,25H,2-4,9,12,17-21H2,1H3/t25-,27+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22378 ((3aS,6aR)-4-(3-methoxyphenyl)-5-[(4E)-oct-4-en-4-y...) Show SMILES CCC\C=C(/CCC)C1=C(c2cccc(OC)c2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1 Show InChI InChI=1S/C29H37NO/c1-4-6-13-22(12-5-2)27-21-24-15-11-19-29(24,30-25-16-8-7-9-17-25)28(27)23-14-10-18-26(20-23)31-3/h7-10,13-14,16-18,20,24,30H,4-6,11-12,15,19,21H2,1-3H3/b22-13+/t24-,29+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	7.5	22
University of Southampton					Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...				J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22388 ((3aS,6aR)-N,4,5-triphenyl-1,2,3,3a,6,6a-hexahydrop...) Show SMILES C1C[C@@H]2CC(=C(c3ccccc3)[C@@]2(C1)Nc1ccccc1)c1ccccc1 Show InChI InChI=1S/C26H25N/c1-4-11-20(12-5-1)24-19-22-15-10-18-26(22,27-23-16-8-3-9-17-23)25(24)21-13-6-2-7-14-21/h1-9,11-14,16-17,22,27H,10,15,18-19H2/t22-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	150	n/a	n/a	7.5	22
University of Southampton					Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...				J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418306 (CHEMBL1765955) Show SMILES C[Si](C)(C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1)c1ccccc1 Show InChI InChI=1S/C30H32Si/c1-23(24-14-7-4-8-15-24)30-21-13-18-26(30)22-28(29(30)25-16-9-5-10-17-25)31(2,3)27-19-11-6-12-20-27/h4-12,14-17,19-20,26H,1,13,18,21-22H2,2-3H3/t26-,30+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	158	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22377 ((3aS,6aR)-4-(4-bromophenyl)-5-[(4E)-oct-4-en-4-yl]...) Show SMILES CCC\C=C(/CCC)C1=C(c2ccc(Br)cc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1 Show InChI InChI=1S/C28H34BrN/c1-3-5-11-21(10-4-2)26-20-23-12-9-19-28(23,30-25-13-7-6-8-14-25)27(26)22-15-17-24(29)18-16-22/h6-8,11,13-18,23,30H,3-5,9-10,12,19-20H2,1-2H3/b21-11+/t23-,28+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	160	n/a	n/a	7.5	22
University of Southampton					Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...				J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418304 (CHEMBL1765953) Show SMILES CCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C26H30/c1-3-4-12-23-19-24-17-11-18-26(24,20(2)21-13-7-5-8-14-21)25(23)22-15-9-6-10-16-22/h5-10,13-16,24H,2-4,11-12,17-19H2,1H3/t24-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22386 ((3aS,6aR)-5-cyclohexyl-N,4-diphenyl-1,2,3,3a,6,6a-...) Show SMILES C1C[C@@H]2CC(C3CCCCC3)=C(c3ccccc3)[C@@]2(C1)Nc1ccccc1 Show InChI InChI=1S/C26H31N/c1-4-11-20(12-5-1)24-19-22-15-10-18-26(22,27-23-16-8-3-9-17-23)25(24)21-13-6-2-7-14-21/h2-3,6-9,13-14,16-17,20,22,27H,1,4-5,10-12,15,18-19H2/t22-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	230	n/a	n/a	7.5	22
University of Southampton					Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...				J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418309 (CHEMBL1765956) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCCC[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C29H36/c1-3-4-5-8-19-26-22-27-20-13-14-21-29(27,23(2)24-15-9-6-10-16-24)28(26)25-17-11-7-12-18-25/h6-7,9-12,15-18,27H,2-5,8,13-14,19-22H2,1H3/t27-,29+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	251	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418310 (CHEMBL1765962) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](OC(C)=O)[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C30H36O2/c1-4-5-6-9-18-26-21-27-28(32-23(3)31)19-20-30(27,22(2)24-14-10-7-11-15-24)29(26)25-16-12-8-13-17-25/h7-8,10-17,27-28H,2,4-6,9,18-21H2,1,3H3/t27-,28-,30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	251	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418308 (CHEMBL1765933) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C28H34/c1-3-4-5-8-18-25-21-26-19-13-20-28(26,22(2)23-14-9-6-10-15-23)27(25)24-16-11-7-12-17-24/h6-7,9-12,14-17,26H,2-5,8,13,18-21H2,1H3/t26-,28+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	251	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418313 (CHEMBL1765945) Show SMILES CCCCCCC1=C(c2cccc(OC)c2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C29H36O/c1-4-5-6-8-15-24-20-26-17-12-19-29(26,22(2)23-13-9-7-10-14-23)28(24)25-16-11-18-27(21-25)30-3/h7,9-11,13-14,16,18,21,26H,2,4-6,8,12,15,17,19-20H2,1,3H3/t26-,29+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	251	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418303 (CHEMBL1765959) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](O)[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-20-25-26(29)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26+,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	251	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418307 (CHEMBL1765934) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1cccc(OC)c1 Show InChI InChI=1S/C29H36O/c1-4-5-6-8-15-25-20-26-17-12-19-29(26,28(25)23-13-9-7-10-14-23)22(2)24-16-11-18-27(21-24)30-3/h7,9-11,13-14,16,18,21,26H,2,4-6,8,12,15,17,19-20H2,1,3H3/t26-,29+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	316	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418325 (CHEMBL1765958) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CN(Cc3ccccc3)C[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C34H39N/c1-3-4-5-11-22-31-23-32-25-35(24-28-16-9-6-10-17-28)26-34(32,27(2)29-18-12-7-13-19-29)33(31)30-20-14-8-15-21-30/h6-10,12-21,32H,2-5,11,22-26H2,1H3/t32-,34-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	316	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22383 ((3aS,6aR)-5-(decan-2-yl)-N,4-diphenyl-1,2,3,3a,6,6...) Show SMILES CCCCCCCCC(C)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1 Show InChI InChI=1S/C30H41N/c1-3-4-5-6-7-10-16-24(2)28-23-26-19-15-22-30(26,31-27-20-13-9-14-21-27)29(28)25-17-11-8-12-18-25/h8-9,11-14,17-18,20-21,24,26,31H,3-7,10,15-16,19,22-23H2,1-2H3/t24?,26-,30+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	320	n/a	n/a	7.5	22
University of Southampton					Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...				J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22389 ((3aS,6aR)-N-(3-fluorophenyl)-5-hexyl-4-phenyl-1,2,...) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1cccc(F)c1 Show InChI InChI=1S/C26H32FN/c1-2-3-4-6-13-21-18-22-14-10-17-26(22,25(21)20-11-7-5-8-12-20)28-24-16-9-15-23(27)19-24/h5,7-9,11-12,15-16,19,22,28H,2-4,6,10,13-14,17-18H2,1H3/t22-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	330	n/a	n/a	7.5	22
University of Southampton					Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...				J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418305 (CHEMBL1765960) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](O)[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-20-25-26(29)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26-,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	398	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418326 (CHEMBL1765961) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](OC(C)=O)[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C30H36O2/c1-4-5-6-9-18-26-21-27-28(32-23(3)31)19-20-30(27,22(2)24-14-10-7-11-15-24)29(26)25-16-12-8-13-17-25/h7-8,10-17,27-28H,2,4-6,9,18-21H2,1,3H3/t27-,28+,30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	398	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50468000 (CHEMBL4288251) Show SMILES O[C@@H]1CC[C@@]2([C@H]1CC(CCCCCCCCCC(O)=O)=C2c1ccccc1)C(=C)c1ccccc1 Show InChI InChI=1S/C32H40O3/c1-24(25-15-10-7-11-16-25)32-22-21-29(33)28(32)23-27(31(32)26-17-12-8-13-18-26)19-9-5-3-2-4-6-14-20-30(34)35/h7-8,10-13,15-18,28-29,33H,1-6,9,14,19-23H2,(H,34,35)/t28-,29+,32-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Agonist activity at recombinant full length human LRH1 expressed in HeLa cells after 24 hrs by dual-glo luciferase reporter gene assay				ACS Med Chem Lett 9: 1051-1056 (2018) Article DOI: 10.1021/acsmedchemlett.8b00361 BindingDB Entry DOI: 10.7270/Q2WW7MCP
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22373 ((3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-1,2,...) Show SMILES CCC\C=C(/CCC)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1 Show InChI InChI=1S/C28H35N/c1-3-5-14-22(13-4-2)26-21-24-17-12-20-28(24,29-25-18-10-7-11-19-25)27(26)23-15-8-6-9-16-23/h6-11,14-16,18-19,24,29H,3-5,12-13,17,20-21H2,1-2H3/b22-14+/t24-,28+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	n/a	n/a	430	n/a	n/a	7.5	22
University of Southampton					Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...				J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT
					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50505380 (CHEMBL4541939) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](NC(N)=O)[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C29H36N2O/c1-3-4-5-8-17-24-20-25-26(31-28(30)32)18-19-29(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26H,2-5,8,17-20H2,1H3,(H3,30,31,32)/t25-,26-,29-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay				J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418316 (CHEMBL1765966) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(C[C@@H](C[C@@H]2C1)OC(C)=O)C(=C)c1ccccc1 Show InChI InChI=1S/C30H36O2/c1-4-5-6-9-18-26-19-27-20-28(32-23(3)31)21-30(27,22(2)24-14-10-7-11-15-24)29(26)25-16-12-8-13-17-25/h7-8,10-17,27-28H,2,4-6,9,18-21H2,1,3H3/t27-,28+,30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	501	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50505376 (CHEMBL4461328) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](OS(N)(=O)=O)[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C28H35NO3S/c1-3-4-5-8-17-24-20-25-26(32-33(29,30)31)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26H,2-5,8,17-20H2,1H3,(H2,29,30,31)/t25-,26-,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	600	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at recombinant human LRH1 ligand binding domain (300 to 537 residues) expressed in Escherichia coli BL21 cells assessed as increase ...				J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753
					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418303 (CHEMBL1765959) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](O)[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-20-25-26(29)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26+,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	600	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at recombinant human LRH1 ligand binding domain (300 to 537 residues) expressed in Escherichia coli BL21 cells assessed as increase ...				J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753
					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50505369 (CHEMBL4440757) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](NS(N)(=O)=O)[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C28H36N2O2S/c1-3-4-5-8-17-24-20-25-26(30-33(29,31)32)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,30H,2-5,8,17-20H2,1H3,(H2,29,31,32)/t25-,26-,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	600	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at recombinant human LRH1 ligand binding domain (300 to 537 residues) expressed in Escherichia coli BL21 cells assessed as increase ...				J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753
					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22373 ((3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-1,2,...) Show SMILES CCC\C=C(/CCC)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1 Show InChI InChI=1S/C28H35N/c1-3-5-14-22(13-4-2)26-21-24-17-12-20-28(24,29-25-18-10-7-11-19-25)27(26)23-15-8-6-9-16-23/h6-11,14-16,18-19,24,29H,3-5,12-13,17,20-21H2,1-2H3/b22-14+/t24-,28+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	n/a	n/a	631	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418329 (CHEMBL1765951) Show SMILES CCCCCCC1=C(CCCO)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C25H36O/c1-3-4-5-7-14-22-19-23-15-10-17-25(23,24(22)16-11-18-26)20(2)21-12-8-6-9-13-21/h6,8-9,12-13,23,26H,2-5,7,10-11,14-19H2,1H3/t23-,25+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	794	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418311 (CHEMBL1765931) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)OC1CCCCC1 Show InChI InChI=1S/C26H38O/c1-2-3-4-7-15-22-20-23-16-12-19-26(23,27-24-17-10-6-11-18-24)25(22)21-13-8-5-9-14-21/h5,8-9,13-14,23-24H,2-4,6-7,10-12,15-20H2,1H3/t23-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	794	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50505371 (CHEMBL4455426) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](OS(N)(=O)=O)[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C28H35NO3S/c1-3-4-5-8-17-24-20-25-26(32-33(29,30)31)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26H,2-5,8,17-20H2,1H3,(H2,29,30,31)/t25-,26+,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	800	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay				J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50505378 (CHEMBL4558553) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](O)[C@@H]2C1)C(=C)Cc1ccccc1 Show InChI InChI=1S/C29H36O/c1-3-4-5-10-17-25-21-26-27(30)18-19-29(26,28(25)24-15-11-7-12-16-24)22(2)20-23-13-8-6-9-14-23/h6-9,11-16,26-27,30H,2-5,10,17-21H2,1H3/t26-,27+,29-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	800	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay				J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50505366 (CHEMBL4452061) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](O)[C@@H]2C1)C(=C)c1ccccc1C Show InChI InChI=1S/C29H36O/c1-4-5-6-8-16-24-20-26-27(30)18-19-29(26,28(24)23-14-9-7-10-15-23)22(3)25-17-12-11-13-21(25)2/h7,9-15,17,26-27,30H,3-6,8,16,18-20H2,1-2H3/t26-,27+,29-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	900	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay				J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50505376 (CHEMBL4461328) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](OS(N)(=O)=O)[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C28H35NO3S/c1-3-4-5-8-17-24-20-25-26(32-33(29,30)31)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26H,2-5,8,17-20H2,1H3,(H2,29,30,31)/t25-,26-,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	900	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay				J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753
					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22390 ((3aS,6aR)-N-(4-chlorophenyl)-5-hexyl-4-phenyl-1,2,...) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccc(Cl)cc1 Show InChI InChI=1S/C26H32ClN/c1-2-3-4-6-12-21-19-22-13-9-18-26(22,25(21)20-10-7-5-8-11-20)28-24-16-14-23(27)15-17-24/h5,7-8,10-11,14-17,22,28H,2-4,6,9,12-13,18-19H2,1H3/t22-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	7.5	22
University of Southampton					Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...				J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418321 (CHEMBL1765963) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(C[C@@H](O)C[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-18-25-19-26(29)20-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26-,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418330 (CHEMBL1765938) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccc(CCCC)cc1 Show InChI InChI=1S/C32H42/c1-4-6-8-10-17-29-24-30-18-13-23-32(30,31(29)28-15-11-9-12-16-28)25(3)27-21-19-26(20-22-27)14-7-5-2/h9,11-12,15-16,19-22,30H,3-8,10,13-14,17-18,23-24H2,1-2H3/t30-,32+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50505370 (CHEMBL4460749) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H]([C@@H]2C1)n1ccnn1)C(=C)c1ccccc1 Show InChI InChI=1S/C30H35N3/c1-3-4-5-8-17-26-22-27-28(33-21-20-31-32-33)18-19-30(27,23(2)24-13-9-6-10-14-24)29(26)25-15-11-7-12-16-25/h6-7,9-16,20-21,27-28H,2-5,8,17-19,22H2,1H3/t27-,28-,30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay				J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418303 (CHEMBL1765959) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](O)[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-20-25-26(29)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26+,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Agonist activity at recombinant full length human LRH1 expressed in HeLa cells after 24 hrs by dual-glo luciferase reporter gene assay				ACS Med Chem Lett 9: 1051-1056 (2018) Article DOI: 10.1021/acsmedchemlett.8b00361 BindingDB Entry DOI: 10.7270/Q2WW7MCP
					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM22395 (N-[(3aS,6aR)-5-hexyl-4-phenyl-1,2,3,3a,6,6a-hexahy...) Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1cccc2ccccc12 Show InChI InChI=1S/C30H35N/c1-2-3-4-6-16-25-22-26-18-12-21-30(26,29(25)24-14-7-5-8-15-24)31-28-20-11-17-23-13-9-10-19-27(23)28/h5,7-11,13-15,17,19-20,26,31H,2-4,6,12,16,18,21-22H2,1H3/t26-,30+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	7.5	22
University of Southampton					Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...				J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT
					More data for this Ligand-Target Pair
Liver Receptor Homolog 1 (Homo sapiens (Human))	BDBM50418317 (CHEMBL1765950) Show SMILES CCCCCCC1=C(C2CCCCC2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1 Show InChI InChI=1S/C28H40/c1-3-4-5-8-18-25-21-26-19-13-20-28(26,22(2)23-14-9-6-10-15-23)27(25)24-16-11-7-12-17-24/h6,9-10,14-15,24,26H,2-5,7-8,11-13,16-21H2,1H3/t26-,28+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a
University of Southampton Curated by ChEMBL					Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control				J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P
					More data for this Ligand-Target Pair

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