Found 1527 Enz. Inhib. hit(s) with Target = 'Lysine-specific demethylase 5A' 
Affinity DataEC50: 90nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataEC50: 110nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 180nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as reduction in demethylation of H3K4me3 after 120 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
Affinity DataEC50: 420nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 530nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as reduction in demethylation of H3K4me3 after 120 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
Affinity DataEC50: 800nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 840nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 860nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 940nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 960nMAssay Description:Non-competitive inhibition of carbonic anhydrase-1 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by Linew...More data for this Ligand-Target Pair
Affinity DataEC50: 990nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30E+3nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30E+3nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.50E+3nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
Affinity DataEC50: 1.60E+3nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
Affinity DataEC50: 4.60E+3nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 5.20E+3nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 levels preincubated for 4 days measured up to 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 5.20E+3nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 levels preincubated for 4 days measured up to 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 6.50E+3nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
Affinity DataEC50: 7.00E+3nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+4nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
Affinity DataKi: 410nMAssay Description:Irreversible inhibition of KDM5A ARID/PhD1 domain deletion mutant (1 to 739 residues) (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.20E+4nMpH: 7.5Assay Description:Human recombinant MAO A and MAO B were expressed in Pichia pastoris and purified as published (Binda C, et al., Proc. Natl. Acad. Sci. USA 100: 9750-...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMpH: 7.5Assay Description:Human recombinant MAO A and MAO B were expressed in Pichia pastoris and purified as published (Binda C, et al., Proc. Natl. Acad. Sci. USA 100: 9750-...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMpH: 7.5Assay Description:Human recombinant MAO A and MAO B were expressed in Pichia pastoris and purified as published (Binda C, et al., Proc. Natl. Acad. Sci. USA 100: 9750-...More data for this Ligand-Target Pair
Affinity DataKi: 3.80E+4nMpH: 7.5Assay Description:Human recombinant MAO A and MAO B were expressed in Pichia pastoris and purified as published (Binda C, et al., Proc. Natl. Acad. Sci. USA 100: 9750-...More data for this Ligand-Target Pair
Affinity DataKi: 6.10E+4nMpH: 7.5Assay Description:Human recombinant MAO A and MAO B were expressed in Pichia pastoris and purified as published (Binda C, et al., Proc. Natl. Acad. Sci. USA 100: 9750-...More data for this Ligand-Target Pair
Affinity DataKi: 7.40E+4nMAssay Description:Mixed type inhibition of KDM5A (L88 to G353 residues) ARID/PHD1/2/3 deletion mutant (unknown origin) demethylation activity using H3(1-21)K4me3 pepti...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+4nMAssay Description:IC50 values of aminodarone analogues using JARID1A PHD3.More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:IC50 values of aminodarone analogues using JARID1A PHD3.More data for this Ligand-Target Pair
Affinity DataIC50: 4.10E+4nMAssay Description:IC50 values of aminodarone analogues using JARID1A PHD3.More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...More data for this Ligand-Target Pair
