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Compile Data Set for Download or QSAR

Found 6399 hits Enz. Inhib. hit(s) with Target = 'Mast/stem cell growth factor receptor Kit'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50242740
PNG
(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)
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n/an/an/an/a 4n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by cellular assay


Proc Natl Acad Sci U S A 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50501882
PNG
(CHEMBL4446361)
Show SMILES Fc1cccc(NC(=O)CC(=O)Nc2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)c1
Show InChI InChI=1S/C23H18FN5O2/c24-15-4-3-6-17(12-15)26-22(30)14-23(31)27-18-7-9-19-20(28-29-21(19)13-18)10-8-16-5-1-2-11-25-16/h1-13H,14H2,(H,26,30)(H,27,31)(H,28,29)/b10-8+
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n/an/an/an/a 34n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of TEL fused wild type c-KIT T670I mutant (unknown origin) transfected in mouse BaF3 cells assessed as reduction in phosphorylation at Y82...


J Med Chem 62: 5006-5024 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00176
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Mus musculus)
BDBM60665
PNG
(BDBM50249542 | US9145414, R406 | US9212178, R406)
Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
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n/an/an/an/a 46n/an/an/an/a



Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of cKit in stem cell factor-stimulated bone marrow derived mouse mast cells assessed as phosphorylation after 1 hr incubation


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50501882
PNG
(CHEMBL4446361)
Show SMILES Fc1cccc(NC(=O)CC(=O)Nc2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)c1
Show InChI InChI=1S/C23H18FN5O2/c24-15-4-3-6-17(12-15)26-22(30)14-23(31)27-18-7-9-19-20(28-29-21(19)13-18)10-8-16-5-1-2-11-25-16/h1-13H,14H2,(H,26,30)(H,27,31)(H,28,29)/b10-8+
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n/an/an/an/a 77n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of TEL fused wild type c-KIT T670I mutant (unknown origin) transfected in mouse BaF3 cells assessed as reduction in phosphorylation at Y70...


J Med Chem 62: 5006-5024 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00176
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50533694
PNG
(CHEMBL4445808)
Show SMILES CCC(=O)NCC1CCN(CC1)c1ccc(NC(=O)Nc2cccc(Oc3ccnc4cc(OC)c(OC)cc34)c2)cc1C(F)(F)F
Show InChI InChI=1S/C34H36F3N5O5/c1-4-32(43)39-20-21-11-14-42(15-12-21)28-9-8-23(17-26(28)34(35,36)37)41-33(44)40-22-6-5-7-24(16-22)47-29-10-13-38-27-19-31(46-3)30(45-2)18-25(27)29/h5-10,13,16-19,21H,4,11-12,14-15,20H2,1-3H3,(H,39,43)(H2,40,41,44)
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n/an/an/an/a<100n/an/an/an/a



High Magnetic Field Laboratory

Curated by ChEMBL


Assay Description
Inhibition of cKIT T670I mutant in human GIST-5R cells assessed as downregulation of ERK phosphorylation at T202/204 after 1 hr by Western blot analy...


J Med Chem 59: 8456-72 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00902
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50533694
PNG
(CHEMBL4445808)
Show SMILES CCC(=O)NCC1CCN(CC1)c1ccc(NC(=O)Nc2cccc(Oc3ccnc4cc(OC)c(OC)cc34)c2)cc1C(F)(F)F
Show InChI InChI=1S/C34H36F3N5O5/c1-4-32(43)39-20-21-11-14-42(15-12-21)28-9-8-23(17-26(28)34(35,36)37)41-33(44)40-22-6-5-7-24(16-22)47-29-10-13-38-27-19-31(46-3)30(45-2)18-25(27)29/h5-10,13,16-19,21H,4,11-12,14-15,20H2,1-3H3,(H,39,43)(H2,40,41,44)
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n/an/an/an/a<100n/an/an/an/a



High Magnetic Field Laboratory

Curated by ChEMBL


Assay Description
Inhibition of wild type cKIT in human GIST-T1 cells assessed as downregulation of AKT phosphorylation at S473 after 1 hr by Western blot analysis


J Med Chem 59: 8456-72 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00902
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50533694
PNG
(CHEMBL4445808)
Show SMILES CCC(=O)NCC1CCN(CC1)c1ccc(NC(=O)Nc2cccc(Oc3ccnc4cc(OC)c(OC)cc34)c2)cc1C(F)(F)F
Show InChI InChI=1S/C34H36F3N5O5/c1-4-32(43)39-20-21-11-14-42(15-12-21)28-9-8-23(17-26(28)34(35,36)37)41-33(44)40-22-6-5-7-24(16-22)47-29-10-13-38-27-19-31(46-3)30(45-2)18-25(27)29/h5-10,13,16-19,21H,4,11-12,14-15,20H2,1-3H3,(H,39,43)(H2,40,41,44)
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n/an/an/an/a<100n/an/an/an/a



High Magnetic Field Laboratory

Curated by ChEMBL


Assay Description
Inhibition of cKIT T670I mutant autophosphorylation at Y703 in human GIST-5R cells at 0.1 to 3 uM after 1 hr by Western blot analysis


J Med Chem 59: 8456-72 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00902
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50533694
PNG
(CHEMBL4445808)
Show SMILES CCC(=O)NCC1CCN(CC1)c1ccc(NC(=O)Nc2cccc(Oc3ccnc4cc(OC)c(OC)cc34)c2)cc1C(F)(F)F
Show InChI InChI=1S/C34H36F3N5O5/c1-4-32(43)39-20-21-11-14-42(15-12-21)28-9-8-23(17-26(28)34(35,36)37)41-33(44)40-22-6-5-7-24(16-22)47-29-10-13-38-27-19-31(46-3)30(45-2)18-25(27)29/h5-10,13,16-19,21H,4,11-12,14-15,20H2,1-3H3,(H,39,43)(H2,40,41,44)
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n/an/an/an/a<100n/an/an/an/a



High Magnetic Field Laboratory

Curated by ChEMBL


Assay Description
Inhibition of cKIT T670I mutant autophosphorylation at Y823 in human GIST-5R cells at 0.1 to 3 uM after 1 hr by Western blot analysis


J Med Chem 59: 8456-72 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00902
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50533694
PNG
(CHEMBL4445808)
Show SMILES CCC(=O)NCC1CCN(CC1)c1ccc(NC(=O)Nc2cccc(Oc3ccnc4cc(OC)c(OC)cc34)c2)cc1C(F)(F)F
Show InChI InChI=1S/C34H36F3N5O5/c1-4-32(43)39-20-21-11-14-42(15-12-21)28-9-8-23(17-26(28)34(35,36)37)41-33(44)40-22-6-5-7-24(16-22)47-29-10-13-38-27-19-31(46-3)30(45-2)18-25(27)29/h5-10,13,16-19,21H,4,11-12,14-15,20H2,1-3H3,(H,39,43)(H2,40,41,44)
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n/an/an/an/a<100n/an/an/an/a



High Magnetic Field Laboratory

Curated by ChEMBL


Assay Description
Inhibition of cKIT T670I mutant in human GIST-5R cells assessed as downregulation of AKT phosphorylation at S473 after 1 hr by Western blot analysis


J Med Chem 59: 8456-72 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00902
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in pS6 phosphorylation at S235 residue measured afte...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in ERK phosphorylation at T204 residue measured after 2 hr...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y703 residue measured afte...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in AKT phosphorylation at T308 residue measured after 2 hr...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y719 residue measured afte...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y703 residue measure...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y719 residue measure...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y823 residue measure...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R cells assessed as reduction in c-KIT autophosphorylation at Y823 residue measure...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in AKT phosphorylation at S473 residue measured after 2 hr...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in pS6 phosphorylation at S236 residue measured after 2 hr...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in ERK phosphorylation at T202 residue measured after 2 hr...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in ERK phosphorylation at T204 residue measured after 2 hr...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in AKT phosphorylation at S473 residue measured afte...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in pS6 phosphorylation at S236 residue measured afte...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in AKT phosphorylation at T308 residue measured after 2 hr...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in AKT phosphorylation at S473 residue measured after 2 hr...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in pS6 phosphorylation at S235 residue measured after 2 hr...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in ERK phosphorylation at T202 residue measured after 2 hr...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R cells assessed as reduction in c-KIT autophosphorylation at Y703 residue measure...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in ERK phosphorylation at T202 residue measured afte...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R cells assessed as reduction in c-KIT autophosphorylation at Y719 residue measure...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in pS6 phosphorylation at S235 residue measured after 2 hr...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in AKT phosphorylation at T308 residue measured afte...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in ERK phosphorylation at T204 residue measured afte...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in pS6 phosphorylation at S236 residue measured after 2 hr...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50515229
PNG
(CHEMBL4577779)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y823 residue measured afte...


J Med Chem 62: 6083-6101 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00280
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50533694
PNG
(CHEMBL4445808)
Show SMILES CCC(=O)NCC1CCN(CC1)c1ccc(NC(=O)Nc2cccc(Oc3ccnc4cc(OC)c(OC)cc34)c2)cc1C(F)(F)F
Show InChI InChI=1S/C34H36F3N5O5/c1-4-32(43)39-20-21-11-14-42(15-12-21)28-9-8-23(17-26(28)34(35,36)37)41-33(44)40-22-6-5-7-24(16-22)47-29-10-13-38-27-19-31(46-3)30(45-2)18-25(27)29/h5-10,13,16-19,21H,4,11-12,14-15,20H2,1-3H3,(H,39,43)(H2,40,41,44)
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n/an/an/an/a<100n/an/an/an/a



High Magnetic Field Laboratory

Curated by ChEMBL


Assay Description
Inhibition of cKIT T670I mutant in human GIST-5R cells assessed as downregulation of S6 phosphorylation at S235/236 after 1 hr by Western blot analys...


J Med Chem 59: 8456-72 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00902
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50533694
PNG
(CHEMBL4445808)
Show SMILES CCC(=O)NCC1CCN(CC1)c1ccc(NC(=O)Nc2cccc(Oc3ccnc4cc(OC)c(OC)cc34)c2)cc1C(F)(F)F
Show InChI InChI=1S/C34H36F3N5O5/c1-4-32(43)39-20-21-11-14-42(15-12-21)28-9-8-23(17-26(28)34(35,36)37)41-33(44)40-22-6-5-7-24(16-22)47-29-10-13-38-27-19-31(46-3)30(45-2)18-25(27)29/h5-10,13,16-19,21H,4,11-12,14-15,20H2,1-3H3,(H,39,43)(H2,40,41,44)
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n/an/an/an/a<100n/an/an/an/a



High Magnetic Field Laboratory

Curated by ChEMBL


Assay Description
Inhibition of cKIT T670I mutant autophosphorylation at Y719 in human GIST-5R cells at 0.1 to 3 uM after 1 hr by Western blot analysis


J Med Chem 59: 8456-72 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00902
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50533694
PNG
(CHEMBL4445808)
Show SMILES CCC(=O)NCC1CCN(CC1)c1ccc(NC(=O)Nc2cccc(Oc3ccnc4cc(OC)c(OC)cc34)c2)cc1C(F)(F)F
Show InChI InChI=1S/C34H36F3N5O5/c1-4-32(43)39-20-21-11-14-42(15-12-21)28-9-8-23(17-26(28)34(35,36)37)41-33(44)40-22-6-5-7-24(16-22)47-29-10-13-38-27-19-31(46-3)30(45-2)18-25(27)29/h5-10,13,16-19,21H,4,11-12,14-15,20H2,1-3H3,(H,39,43)(H2,40,41,44)
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n/an/an/an/a<100n/an/an/an/a



High Magnetic Field Laboratory

Curated by ChEMBL


Assay Description
Inhibition of wild type cKIT in human GIST-T1 cells assessed as downregulation of ERK phosphorylation at T202//204 after 1 hr by Western blot analysi...


J Med Chem 59: 8456-72 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00902
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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n/an/an/an/a 100n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by cellular assay


Proc Natl Acad Sci U S A 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50533694
PNG
(CHEMBL4445808)
Show SMILES CCC(=O)NCC1CCN(CC1)c1ccc(NC(=O)Nc2cccc(Oc3ccnc4cc(OC)c(OC)cc34)c2)cc1C(F)(F)F
Show InChI InChI=1S/C34H36F3N5O5/c1-4-32(43)39-20-21-11-14-42(15-12-21)28-9-8-23(17-26(28)34(35,36)37)41-33(44)40-22-6-5-7-24(16-22)47-29-10-13-38-27-19-31(46-3)30(45-2)18-25(27)29/h5-10,13,16-19,21H,4,11-12,14-15,20H2,1-3H3,(H,39,43)(H2,40,41,44)
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n/an/an/an/a<100n/an/an/an/a



High Magnetic Field Laboratory

Curated by ChEMBL


Assay Description
Inhibition of wild type cKIT in human GIST-T1 cells assessed as downregulation of S6 phosphorylation at S235/236 after 1 hr by Western blot analysis


J Med Chem 59: 8456-72 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00902
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Mus musculus)
BDBM50015448
PNG
(CHEMBL3265032)
Show SMILES C1CN(CCO1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C23H21N7O/c1-2-17-14-25-28-20(17)13-16(1)21-15-30-8-7-24-23(30)22(27-21)26-18-3-5-19(6-4-18)29-9-11-31-12-10-29/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)
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n/an/an/an/a 445n/an/an/an/a



Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of cKit in stem cell factor-stimulated bone marrow derived mouse mast cells assessed as phosphorylation after 1 hr incubation


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50501882
PNG
(CHEMBL4446361)
Show SMILES Fc1cccc(NC(=O)CC(=O)Nc2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)c1
Show InChI InChI=1S/C23H18FN5O2/c24-15-4-3-6-17(12-15)26-22(30)14-23(31)27-18-7-9-19-20(28-29-21(19)13-18)10-8-16-5-1-2-11-25-16/h1-13H,14H2,(H,26,30)(H,27,31)(H,28,29)/b10-8+
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n/an/an/an/a 750n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of TEL fused wild type c-KIT T670I mutant (unknown origin) transfected in mouse BaF3 cells assessed as reduction in phosphorylation at Y71...


J Med Chem 62: 5006-5024 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00176
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50501882
PNG
(CHEMBL4446361)
Show SMILES Fc1cccc(NC(=O)CC(=O)Nc2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)c1
Show InChI InChI=1S/C23H18FN5O2/c24-15-4-3-6-17(12-15)26-22(30)14-23(31)27-18-7-9-19-20(28-29-21(19)13-18)10-8-16-5-1-2-11-25-16/h1-13H,14H2,(H,26,30)(H,27,31)(H,28,29)/b10-8+
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n/an/an/an/a 1.00E+3n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of TEL fused wild type c-KIT (unknown origin) transfected in mouse BaF3 cells assessed as reduction in phosphorylation at Y823 residue aft...


J Med Chem 62: 5006-5024 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00176
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50501882
PNG
(CHEMBL4446361)
Show SMILES Fc1cccc(NC(=O)CC(=O)Nc2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)c1
Show InChI InChI=1S/C23H18FN5O2/c24-15-4-3-6-17(12-15)26-22(30)14-23(31)27-18-7-9-19-20(28-29-21(19)13-18)10-8-16-5-1-2-11-25-16/h1-13H,14H2,(H,26,30)(H,27,31)(H,28,29)/b10-8+
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n/an/an/an/a>1.00E+3n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of TEL fused wild type c-KIT (unknown origin) transfected in mouse BaF3 cells assessed as reduction in phosphorylation at Y703 residue aft...


J Med Chem 62: 5006-5024 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00176
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50501882
PNG
(CHEMBL4446361)
Show SMILES Fc1cccc(NC(=O)CC(=O)Nc2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)c1
Show InChI InChI=1S/C23H18FN5O2/c24-15-4-3-6-17(12-15)26-22(30)14-23(31)27-18-7-9-19-20(28-29-21(19)13-18)10-8-16-5-1-2-11-25-16/h1-13H,14H2,(H,26,30)(H,27,31)(H,28,29)/b10-8+
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n/an/an/an/a>1.00E+3n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of TEL fused wild type c-KIT (unknown origin) transfected in mouse BaF3 cells assessed as reduction in phosphorylation at Y719 residue aft...


J Med Chem 62: 5006-5024 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00176
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346074
PNG
(4-[2-(1,6-Dimethyl-2- m-tolyl-1H- benzoimidazol-5-...)
Show SMILES Cc1cccc(c1)-c1nc2cc(Nc3nc(cs3)-c3ccc(cc3)C#N)c(C)cc2n1C
Show InChI InChI=1S/C26H21N5S/c1-16-5-4-6-20(11-16)25-28-22-13-21(17(2)12-24(22)31(25)3)29-26-30-23(15-32-26)19-9-7-18(14-27)8-10-19/h4-13,15H,1-3H3,(H,29,30)
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n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346075
PNG
(4-{2-[1,6-Dimethyl-2- (3-trifluoromethyl- phenyl)-...)
Show SMILES Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1ccc(cc1)C#N)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H18F3N5S/c1-15-10-23-21(31-24(34(23)2)18-4-3-5-19(11-18)26(27,28)29)12-20(15)32-25-33-22(14-35-25)17-8-6-16(13-30)7-9-17/h3-12,14H,1-2H3,(H,32,33)
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n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346076
PNG
(US10202370, Example 115 | [1-Ethyl-6-methyl-2- (3-...)
Show SMILES CCn1c(nc2cc(Nc3nc(cs3)-c3cccnc3)c(C)cc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H20F3N5OS/c1-3-33-22-10-15(2)19(31-24-32-21(14-35-24)17-7-5-9-29-13-17)12-20(22)30-23(33)16-6-4-8-18(11-16)34-25(26,27)28/h4-14H,3H2,1-2H3,(H,31,32)
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n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346077
PNG
(US10202370, Example 119 | [4-(2-Chloro-pyridin- 4-...)
Show SMILES Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1ccnc(Cl)c1)-c1cccc(c1)C(F)F
Show InChI InChI=1S/C24H18ClF2N5S/c1-13-8-20-18(29-23(32(20)2)16-5-3-4-15(9-16)22(26)27)11-17(13)30-24-31-19(12-33-24)14-6-7-28-21(25)10-14/h3-12,22H,1-2H3,(H,30,31)
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n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
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