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Compile Data Set for Download or QSAR

Found 5722 hits Enz. Inhib. hit(s) with Target = 'Mast/stem cell growth factor receptor Kit'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50242740
PNG
(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)
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n/an/an/an/a 4n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Mus musculus)
BDBM60665
PNG
(BDBM50249542 | US9145414, R406 | US9212178, R406)
Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
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n/an/an/an/a 46n/an/an/an/a



Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of cKit in stem cell factor-stimulated bone marrow derived mouse mast cells assessed as phosphorylation after 1 hr incubation


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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n/an/an/an/a 100n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Mus musculus)
BDBM50015448
PNG
(CHEMBL3265032)
Show SMILES C1CN(CCO1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C23H21N7O/c1-2-17-14-25-28-20(17)13-16(1)21-15-30-8-7-24-23(30)22(27-21)26-18-3-5-19(6-4-18)29-9-11-31-12-10-29/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)
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Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of cKit in stem cell factor-stimulated bone marrow derived mouse mast cells assessed as phosphorylation after 1 hr incubation


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346074
PNG
(4-[2-(1,6-Dimethyl-2- m-tolyl-1H- benzoimidazol-5-...)
Show SMILES Cc1cccc(c1)-c1nc2cc(Nc3nc(cs3)-c3ccc(cc3)C#N)c(C)cc2n1C
Show InChI InChI=1S/C26H21N5S/c1-16-5-4-6-20(11-16)25-28-22-13-21(17(2)12-24(22)31(25)3)29-26-30-23(15-32-26)19-9-7-18(14-27)8-10-19/h4-13,15H,1-3H3,(H,29,30)
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n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346075
PNG
(4-{2-[1,6-Dimethyl-2- (3-trifluoromethyl- phenyl)-...)
Show SMILES Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1ccc(cc1)C#N)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H18F3N5S/c1-15-10-23-21(31-24(34(23)2)18-4-3-5-19(11-18)26(27,28)29)12-20(15)32-25-33-22(14-35-25)17-8-6-16(13-30)7-9-17/h3-12,14H,1-2H3,(H,32,33)
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AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346076
PNG
(US10202370, Example 115 | [1-Ethyl-6-methyl-2- (3-...)
Show SMILES CCn1c(nc2cc(Nc3nc(cs3)-c3cccnc3)c(C)cc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H20F3N5OS/c1-3-33-22-10-15(2)19(31-24-32-21(14-35-24)17-7-5-9-29-13-17)12-20(22)30-23(33)16-6-4-8-18(11-16)34-25(26,27)28/h4-14H,3H2,1-2H3,(H,31,32)
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Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346077
PNG
(US10202370, Example 119 | [4-(2-Chloro-pyridin- 4-...)
Show SMILES Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1ccnc(Cl)c1)-c1cccc(c1)C(F)F
Show InChI InChI=1S/C24H18ClF2N5S/c1-13-8-20-18(29-23(32(20)2)16-5-3-4-15(9-16)22(26)27)11-17(13)30-24-31-19(12-33-24)14-6-7-28-21(25)10-14/h3-12,22H,1-2H3,(H,30,31)
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Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346078
PNG
(US10202370, Example 120 | [2-(3- Methanesulfonyl- ...)
Show SMILES Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1ccncc1)-c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C24H21N5O2S2/c1-15-11-22-20(26-23(29(22)2)17-5-4-6-18(12-17)33(3,30)31)13-19(15)27-24-28-21(14-32-24)16-7-9-25-10-8-16/h4-14H,1-3H3,(H,27,28)
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Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346079
PNG
(US10202370, Example 121 | [2-(3- Methanesulfonyl- ...)
Show SMILES Cc1cc2[nH]c(nc2cc1Nc1nc(cs1)-c1cccnc1)-c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C23H19N5O2S2/c1-14-9-19-20(26-22(25-19)15-5-3-7-17(10-15)32(2,29)30)11-18(14)27-23-28-21(13-31-23)16-6-4-8-24-12-16/h3-13H,1-2H3,(H,25,26)(H,27,28)
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n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346080
PNG
(US10202370, Example 124 | [2-(3-Fluoro-phenyl)- 1,...)
Show SMILES Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1ccncc1)-c1cccc(F)c1
Show InChI InChI=1S/C23H18FN5S/c1-14-10-21-19(26-22(29(21)2)16-4-3-5-17(24)11-16)12-18(14)27-23-28-20(13-30-23)15-6-8-25-9-7-15/h3-13H,1-2H3,(H,27,28)
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Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346081
PNG
(US10202370, Example 125 | [2-(3-Methoxy- phenyl)-1...)
Show SMILES COc1cccc(c1)-c1nc2cc(Nc3nc(cs3)-c3ccncc3)c(C)cc2n1C
Show InChI InChI=1S/C24H21N5OS/c1-15-11-22-20(26-23(29(22)2)17-5-4-6-18(12-17)30-3)13-19(15)27-24-28-21(14-31-24)16-7-9-25-10-8-16/h4-14H,1-3H3,(H,27,28)
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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346082
PNG
(US10202370, Example 126 | [2-(3-Methoxy- phenyl)-6...)
Show SMILES COc1cccc(c1)-c1nc2cc(Nc3nc(cs3)-c3cccnc3)c(C)cc2[nH]1
Show InChI InChI=1S/C23H19N5OS/c1-14-9-19-20(26-22(25-19)15-5-3-7-17(10-15)29-2)11-18(14)27-23-28-21(13-30-23)16-6-4-8-24-12-16/h3-13H,1-2H3,(H,25,26)(H,27,28)
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n/an/an/an/a<1.00E+3n/an/an/an/a



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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346083
PNG
(3-{2-[2-(3- Difluoromethyl- phenyl)-6-methyl- 3H-b...)
Show SMILES Cc1cc2nc([nH]c2cc1Nc1nc(cs1)-c1cccc(c1)C#N)-c1cccc(c1)C(F)F
Show InChI InChI=1S/C25H17F2N5S/c1-14-8-20-21(30-24(29-20)18-7-3-6-17(10-18)23(26)27)11-19(14)31-25-32-22(13-33-25)16-5-2-4-15(9-16)12-28/h2-11,13,23H,1H3,(H,29,30)(H,31,32)
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n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346084
PNG
(4-{2-[2-(3-Methoxy- phenyl)-6-methyl- 1H-benzoimid...)
Show SMILES COc1cccc(c1)-c1nc2cc(Nc3nc(cs3)-c3ccc(cc3)C#N)c(C)cc2[nH]1
Show InChI InChI=1S/C25H19N5OS/c1-15-10-21-22(28-24(27-21)18-4-3-5-19(11-18)31-2)12-20(15)29-25-30-23(14-32-25)17-8-6-16(13-26)7-9-17/h3-12,14H,1-2H3,(H,27,28)(H,29,30)
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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346085
PNG
(3-[2-(6-Methyl-2-m- tolyl-1H- benzoimidazol-5- yla...)
Show SMILES Cc1cccc(c1)-c1nc2cc(Nc3nc(cs3)-c3cccc(c3)C#N)c(C)cc2[nH]1
Show InChI InChI=1S/C25H19N5S/c1-15-5-3-8-19(9-15)24-27-21-10-16(2)20(12-22(21)28-24)29-25-30-23(14-31-25)18-7-4-6-17(11-18)13-26/h3-12,14H,1-2H3,(H,27,28)(H,29,30)
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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346086
PNG
(3-{2-[6-Methyl-2-(3- trifluoromethyl- phenyl)-1H- ...)
Show SMILES Cc1cc2[nH]c(nc2cc1Nc1nc(cs1)-c1cccc(c1)C#N)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H16F3N5S/c1-14-8-20-21(31-23(30-20)17-6-3-7-18(10-17)25(26,27)28)11-19(14)32-24-33-22(13-34-24)16-5-2-4-15(9-16)12-29/h2-11,13H,1H3,(H,30,31)(H,32,33)
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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346087
PNG
(4-{2-[2-(3- Methanesulfonyl- phenyl)-6-methyl- 1H-...)
Show SMILES Cc1cc2[nH]c(nc2cc1Nc1nc(cs1)-c1ccc(cc1)C#N)-c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C25H19N5O2S2/c1-15-10-21-22(28-24(27-21)18-4-3-5-19(11-18)34(2,31)32)12-20(15)29-25-30-23(14-33-25)17-8-6-16(13-26)7-9-17/h3-12,14H,1-2H3,(H,27,28)(H,29,30)
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n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346088
PNG
(US10202370, Example 132 | [2-(3- Dimethylamino- ph...)
Show SMILES CN(C)c1cccc(c1)-c1nc2cc(C)c(Nc3nc(cs3)-c3cccnc3)cc2[nH]1
Show InChI InChI=1S/C24H22N6S/c1-15-10-20-21(27-23(26-20)16-6-4-8-18(11-16)30(2)3)12-19(15)28-24-29-22(14-31-24)17-7-5-9-25-13-17/h4-14H,1-3H3,(H,26,27)(H,28,29)
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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346089
PNG
(US10202370, Example 133 | [2-(3- Dimethylamino- ph...)
Show SMILES CN(C)c1cccc(c1)-c1nc2cc(Nc3nc(cs3)-c3ccncc3)c(C)cc2n1C
Show InChI InChI=1S/C25H24N6S/c1-16-12-23-21(27-24(31(23)4)18-6-5-7-19(13-18)30(2)3)14-20(16)28-25-29-22(15-32-25)17-8-10-26-11-9-17/h5-15H,1-4H3,(H,28,29)
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n/an/an/an/a<1.00E+3n/an/an/an/a



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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346090
PNG
(US10202370, Example 136 | [2-(3-Isopropyl- phenyl)...)
Show SMILES CC(C)c1cccc(c1)-c1nc2cc(Nc3nc(cs3)-c3cccnc3)c(C)cc2[nH]1
Show InChI InChI=1S/C25H23N5S/c1-15(2)17-6-4-7-18(11-17)24-27-21-10-16(3)20(12-22(21)28-24)29-25-30-23(14-31-25)19-8-5-9-26-13-19/h4-15H,1-3H3,(H,27,28)(H,29,30)
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n/an/an/an/a<1.00E+3n/an/an/an/a



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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346091
PNG
(US10202370, Example 137 | [2-(3-tert-Butyl- phenyl...)
Show SMILES Cc1cc2[nH]c(nc2cc1Nc1nc(cs1)-c1cccnc1)-c1cccc(c1)C(C)(C)C
Show InChI InChI=1S/C26H25N5S/c1-16-11-21-22(29-24(28-21)17-7-5-9-19(12-17)26(2,3)4)13-20(16)30-25-31-23(15-32-25)18-8-6-10-27-14-18/h5-15H,1-4H3,(H,28,29)(H,30,31)
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n/an/an/an/a<1.00E+3n/an/an/an/a



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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346092
PNG
(4-{2-[2-(3-Fluoro-5- trifluoromethyl- phenyl)-1,6-...)
Show SMILES Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1ccc(cc1)C#N)-c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C26H17F4N5S/c1-14-7-23-21(32-24(35(23)2)17-8-18(26(28,29)30)10-19(27)9-17)11-20(14)33-25-34-22(13-36-25)16-5-3-15(12-31)4-6-16/h3-11,13H,1-2H3,(H,33,34)
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n/an/an/an/a<1.00E+3n/an/an/an/a



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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346093
PNG
(US10202370, Example 139 | [2-(3-Ethynyl- phenyl)-6...)
Show SMILES Cc1cc2[nH]c(nc2cc1Nc1nc(cs1)-c1cccnc1)-c1cccc(c1)C#C
Show InChI InChI=1S/C24H17N5S/c1-3-16-6-4-7-17(11-16)23-26-20-10-15(2)19(12-21(20)27-23)28-24-29-22(14-30-24)18-8-5-9-25-13-18/h1,4-14H,2H3,(H,26,27)(H,28,29)
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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346094
PNG
(US10202370, Example 140 | [2-(3-Isopropyl- phenyl)...)
Show SMILES CC(C)c1cccc(c1)-c1nc2cc(Nc3nc(cs3)-c3cccnc3)c(C)cc2n1C
Show InChI InChI=1S/C26H25N5S/c1-16(2)18-7-5-8-19(12-18)25-28-22-13-21(17(3)11-24(22)31(25)4)29-26-30-23(15-32-26)20-9-6-10-27-14-20/h5-16H,1-4H3,(H,29,30)
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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346095
PNG
(4-{2-[2-(3-Ethynyl- phenyl)-6-methyl- 1H-benzoimid...)
Show SMILES Cc1cc2[nH]c(nc2cc1Nc1nc(cs1)-c1ccc(cc1)C#N)-c1cccc(c1)C#C
Show InChI InChI=1S/C26H17N5S/c1-3-17-5-4-6-20(12-17)25-28-22-11-16(2)21(13-23(22)29-25)30-26-31-24(15-32-26)19-9-7-18(14-27)8-10-19/h1,4-13,15H,2H3,(H,28,29)(H,30,31)
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n/an/an/an/a<1.00E+3n/an/an/an/a



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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346096
PNG
(4-{2-[2-(3-Isopropyl- phenyl)-1,6- dimethyl-1H- be...)
Show SMILES CC(C)c1cccc(c1)-c1nc2cc(Nc3nc(cs3)-c3ccc(cc3)C#N)c(C)cc2n1C
Show InChI InChI=1S/C28H25N5S/c1-17(2)21-6-5-7-22(13-21)27-30-24-14-23(18(3)12-26(24)33(27)4)31-28-32-25(16-34-28)20-10-8-19(15-29)9-11-20/h5-14,16-17H,1-4H3,(H,31,32)
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n/an/an/an/a<1.00E+3n/an/an/an/a



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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346097
PNG
(4-{2-[2-(3-Isopropyl- phenyl)-6-methyl- 1H-benzoim...)
Show SMILES CC(C)c1cccc(c1)-c1nc2cc(Nc3nc(cs3)-c3ccc(cc3)C#N)c(C)cc2[nH]1
Show InChI InChI=1S/C27H23N5S/c1-16(2)20-5-4-6-21(12-20)26-29-23-11-17(3)22(13-24(23)30-26)31-27-32-25(15-33-27)19-9-7-18(14-28)8-10-19/h4-13,15-16H,1-3H3,(H,29,30)(H,31,32)
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n/an/an/an/a<1.00E+3n/an/an/an/a



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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346098
PNG
(4-{2-[2-(3-tert-Butyl- phenyl)-1,6- dimethyl-1H- b...)
Show SMILES Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1ccc(cc1)C#N)-c1cccc(c1)C(C)(C)C
Show InChI InChI=1S/C29H27N5S/c1-18-13-26-24(31-27(34(26)5)21-7-6-8-22(14-21)29(2,3)4)15-23(18)32-28-33-25(17-35-28)20-11-9-19(16-30)10-12-20/h6-15,17H,1-5H3,(H,32,33)
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n/an/an/an/a<1.00E+3n/an/an/an/a



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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346099
PNG
(US10202370, Example 145 | [2-(3-tert-Butyl- phenyl...)
Show SMILES Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1cccnc1)-c1cccc(c1)C(C)(C)C
Show InChI InChI=1S/C27H27N5S/c1-17-12-24-22(29-25(32(24)5)18-8-6-10-20(13-18)27(2,3)4)14-21(17)30-26-31-23(16-33-26)19-9-7-11-28-15-19/h6-16H,1-5H3,(H,30,31)
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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346100
PNG
(US10202370, Example 146 | [2-(3-Ethynyl- phenyl)-1...)
Show SMILES Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1cccnc1)-c1cccc(c1)C#C
Show InChI InChI=1S/C25H19N5S/c1-4-17-7-5-8-18(12-17)24-27-21-13-20(16(2)11-23(21)30(24)3)28-25-29-22(15-31-25)19-9-6-10-26-14-19/h1,5-15H,2-3H3,(H,28,29)
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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346101
PNG
(US10202370, Example 147 | [2-(3-Fluoro-5- trifluor...)
Show SMILES Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1ccncc1)-c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C24H17F4N5S/c1-13-7-21-19(11-18(13)31-23-32-20(12-34-23)14-3-5-29-6-4-14)30-22(33(21)2)15-8-16(24(26,27)28)10-17(25)9-15/h3-12H,1-2H3,(H,31,32)
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n/an/an/an/a<1.00E+3n/an/an/an/a



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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346102
PNG
(US10202370, Example 148 | [2-(3-Fluoro-5- trifluor...)
Show SMILES Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1cccnc1)-c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C24H17F4N5S/c1-13-6-21-19(10-18(13)31-23-32-20(12-34-23)14-4-3-5-29-11-14)30-22(33(21)2)15-7-16(24(26,27)28)9-17(25)8-15/h3-12H,1-2H3,(H,31,32)
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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346103
PNG
(US10202370, Example 149 | [2-(3-Fluoro-5- trifluor...)
Show SMILES Cc1cc2[nH]c(nc2cc1Nc1nc(cs1)-c1ccncc1)-c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C23H15F4N5S/c1-12-6-18-19(30-21(29-18)14-7-15(23(25,26)27)9-16(24)8-14)10-17(12)31-22-32-20(11-33-22)13-2-4-28-5-3-13/h2-11H,1H3,(H,29,30)(H,31,32)
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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346104
PNG
(US10202370, Example 150 | [2-(3-Isopropyl- phenyl)...)
Show SMILES CC(C)c1cccc(c1)-c1nc2cc(Nc3nc(cs3)-c3ccncc3)c(C)cc2[nH]1
Show InChI InChI=1S/C25H23N5S/c1-15(2)18-5-4-6-19(12-18)24-27-21-11-16(3)20(13-22(21)28-24)29-25-30-23(14-31-25)17-7-9-26-10-8-17/h4-15H,1-3H3,(H,27,28)(H,29,30)
PDB

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n/an/an/an/a<1.00E+3n/an/an/an/a



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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346105
PNG
(US10202370, Example 151 | [2-(3-Isopropyl- phenyl)...)
Show SMILES CC(C)c1cccc(c1)-c1nc2cc(Nc3nc(cs3)-c3ccncc3)c(C)cc2n1C
Show InChI InChI=1S/C26H25N5S/c1-16(2)19-6-5-7-20(13-19)25-28-22-14-21(17(3)12-24(22)31(25)4)29-26-30-23(15-32-26)18-8-10-27-11-9-18/h5-16H,1-4H3,(H,29,30)
PDB

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n/an/an/an/a<1.00E+3n/an/an/an/a



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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346106
PNG
(US10202370, Example 152 | [2-(3-tert-Butyl- phenyl...)
Show SMILES Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1ccncc1)-c1cccc(c1)C(C)(C)C
Show InChI InChI=1S/C27H27N5S/c1-17-13-24-22(29-25(32(24)5)19-7-6-8-20(14-19)27(2,3)4)15-21(17)30-26-31-23(16-33-26)18-9-11-28-12-10-18/h6-16H,1-5H3,(H,30,31)
PDB

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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346107
PNG
(US10202370, Example 153 | [2-(3-tert-Butyl- phenyl...)
Show SMILES Cc1cc2[nH]c(nc2cc1Nc1nc(cs1)-c1ccncc1)-c1cccc(c1)C(C)(C)C
Show InChI InChI=1S/C26H25N5S/c1-16-12-21-22(29-24(28-21)18-6-5-7-19(13-18)26(2,3)4)14-20(16)30-25-31-23(15-32-25)17-8-10-27-11-9-17/h5-15H,1-4H3,(H,28,29)(H,30,31)
PDB

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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346108
PNG
(4-{2-[2-(3-tert-Butyl- phenyl)-6-methyl- 1H-benzoi...)
Show SMILES Cc1cc2[nH]c(nc2cc1Nc1nc(cs1)-c1ccc(cc1)C#N)-c1cccc(c1)C(C)(C)C
Show InChI InChI=1S/C28H25N5S/c1-17-12-23-24(31-26(30-23)20-6-5-7-21(13-20)28(2,3)4)14-22(17)32-27-33-25(16-34-27)19-10-8-18(15-29)9-11-19/h5-14,16H,1-4H3,(H,30,31)(H,32,33)
PDB

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US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50242742
PNG
(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of c-Kit by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346014
PNG
(US10202370, Example 003 | {6-Methyl-2-[4-(4- methy...)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2nc3cc(C)c(Nc4nc(cs4)-c4cccnc4)cc3[nH]2)CC1
Show InChI InChI=1S/C28H29N7S/c1-19-14-24-25(15-23(19)32-28-33-26(18-36-28)22-4-3-9-29-16-22)31-27(30-24)21-7-5-20(6-8-21)17-35-12-10-34(2)11-13-35/h3-9,14-16,18H,10-13,17H2,1-2H3,(H,30,31)(H,32,33)
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n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

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Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346015
PNG
(US10202370, Example 005 | [6-Methyl-2-(3- trifluor...)
Show SMILES Cc1cc2nc([nH]c2cc1Nc1nc(cs1)-c1cccnc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H16F3N5S/c1-13-8-18-19(29-21(28-18)14-4-2-6-16(9-14)23(24,25)26)10-17(13)30-22-31-20(12-32-22)15-5-3-7-27-11-15/h2-12H,1H3,(H,28,29)(H,30,31)
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n/an/an/an/a<1.00E+3n/an/an/an/a



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Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346016
PNG
(US10202370, Example 008 | [6-Methyl-2-(3- trifluor...)
Show SMILES Cc1cc2nc([nH]c2cc1Nc1nccc(n1)-c1cccnc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H17F3N6/c1-14-10-20-21(31-22(30-20)15-4-2-6-17(11-15)24(25,26)27)12-19(14)33-23-29-9-7-18(32-23)16-5-3-8-28-13-16/h2-13H,1H3,(H,30,31)(H,29,32,33)
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n/an/an/an/a<1.00E+3n/an/an/an/a



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Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346017
PNG
(3-[5-Methyl-6-(4- pyridin-3-yl-thiazol- 2-ylamino)...)
Show SMILES Cc1cc2nc([nH]c2cc1Nc1nc(cs1)-c1cccnc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C23H16N6S/c1-14-8-19-20(27-22(26-19)16-5-2-4-15(9-16)11-24)10-18(14)28-23-29-21(13-30-23)17-6-3-7-25-12-17/h2-10,12-13H,1H3,(H,26,27)(H,28,29)
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n/an/an/an/a<1.00E+3n/an/an/an/a



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Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346018
PNG
((6-Methyl-2-m-tolyl- 3H-benzoimidazol-5- yl)-(4-py...)
Show SMILES Cc1cccc(c1)-c1nc2cc(C)c(Nc3nc(cs3)-c3cccnc3)cc2[nH]1
Show InChI InChI=1S/C23H19N5S/c1-14-5-3-6-16(9-14)22-25-19-10-15(2)18(11-20(19)26-22)27-23-28-21(13-29-23)17-7-4-8-24-12-17/h3-13H,1-2H3,(H,25,26)(H,27,28)
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n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346019
PNG
(US10202370, Example 020 | [6-Methyl-2-(3- morpholi...)
Show SMILES Cc1cc2nc([nH]c2cc1Nc1nc(cs1)-c1cccnc1)-c1cc(CN2CCOCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H25F3N6OS/c1-17-9-23-24(13-22(17)35-27-36-25(16-39-27)19-3-2-4-32-14-19)34-26(33-23)20-10-18(11-21(12-20)28(29,30)31)15-37-5-7-38-8-6-37/h2-4,9-14,16H,5-8,15H2,1H3,(H,33,34)(H,35,36)
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n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

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Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346020
PNG
(US10202370, Example 024 | [6-Methyl-2-(3- piperidi...)
Show SMILES Cc1cc2nc([nH]c2cc1Nc1nc(cs1)-c1cccnc1)-c1cc(CN2CCCCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H27F3N6S/c1-18-10-24-25(14-23(18)36-28-37-26(17-39-28)20-6-5-7-33-15-20)35-27(34-24)21-11-19(12-22(13-21)29(30,31)32)16-38-8-3-2-4-9-38/h5-7,10-15,17H,2-4,8-9,16H2,1H3,(H,34,35)(H,36,37)
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n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346021
PNG
(US10202370, Example 025 | [2-(3-Difluoromethyl- ph...)
Show SMILES Cc1cc2nc([nH]c2cc1Nc1nc(cs1)-c1cccnc1)-c1cccc(c1)C(F)F
Show InChI InChI=1S/C23H17F2N5S/c1-13-8-18-19(28-22(27-18)15-5-2-4-14(9-15)21(24)25)10-17(13)29-23-30-20(12-31-23)16-6-3-7-26-11-16/h2-12,21H,1H3,(H,27,28)(H,29,30)
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n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346022
PNG
(US10202370, Example 026 | [6-Methyl-2-(3- trifluor...)
Show SMILES Cc1cc2nc([nH]c2cc1Nc1nc(cs1)-c1cccnc1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H16F3N5OS/c1-13-8-18-19(29-21(28-18)14-4-2-6-16(9-14)32-23(24,25)26)10-17(13)30-22-31-20(12-33-22)15-5-3-7-27-11-15/h2-12H,1H3,(H,28,29)(H,30,31)
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n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346023
PNG
(US10202370, Example 028 | [6-Methyl-2-(3- morpholi...)
Show SMILES Cc1cc2nc([nH]c2cc1Nc1nccc(n1)-c1cccnc1)-c1cc(CN2CCOCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H26F3N7O/c1-18-11-25-26(15-24(18)38-28-34-6-4-23(37-28)20-3-2-5-33-16-20)36-27(35-25)21-12-19(13-22(14-21)29(30,31)32)17-39-7-9-40-10-8-39/h2-6,11-16H,7-10,17H2,1H3,(H,35,36)(H,34,37,38)
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n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)


Article DOI: 10.1016/j.str.2004.10.004
BindingDB Entry DOI: 10.7270/Q2Q52RRK
More data for this
Ligand-Target Pair
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