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Compile Data Set for Download or QSAR

Found 234 hits Enz. Inhib. hit(s) with Target = 'Matrix M2-1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM301476
PNG
(US10131673, Compound P3)
Show SMILES Cc1ccc(NS(C)(=O)=O)c(c1)C(=O)N1CCCC[C@H]1c1cc2nc3CCCCc3c(N3CCOCC3)n2n1
Show InChI InChI=1S/C28H36N6O4S/c1-19-10-11-23(31-39(2,36)37)21(17-19)28(35)33-12-6-5-9-25(33)24-18-26-29-22-8-4-3-7-20(22)27(34(26)30-24)32-13-15-38-16-14-32/h10-11,17-18,25,31H,3-9,12-16H2,1-2H3/t25-/m0/s1
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n/an/an/an/a 0.562n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Black 384-well clear-bottom microtiter plates (Corning, Amsterdam, The Netherlands) were filled via acoustic drop ejection using the echo liquid hand...


US Patent US10131673 (2018)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324744
PNG
(1'-({5-Chloro-1-[2-(1,1- dioxidothietan-3-yl)ethyl...)
Show SMILES Clc1ccc2n(CCC3CS(=O)(=O)C3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C22H21ClN4O3S/c23-15-1-2-18-17(9-15)25-20(26(18)8-4-14-12-31(29,30)13-14)11-27-19-10-24-7-3-16(19)22(5-6-22)21(27)28/h1-3,7,9-10,14H,4-6,8,11-13H2
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n/an/an/an/a 1.10n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM301499
PNG
(N-(2-(2-(9-(dimethylamino)-5-methyl-5,6,7,8-tetrah...)
Show SMILES CN(C)c1c2CCCN(C)c2nc2cc(nn12)C1CCCCN1C(=O)c1cc(C)ccc1NS(C)(=O)=O
Show InChI InChI=1S/C26H35N7O3S/c1-17-11-12-20(29-37(5,35)36)19(15-17)26(34)32-14-7-6-10-22(32)21-16-23-27-24-18(9-8-13-31(24)4)25(30(2)3)33(23)28-21/h11-12,15-16,22,29H,6-10,13-14H2,1-5H3
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n/an/an/an/a 1.58n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Black 384-well clear-bottom microtiter plates (Corning, Amsterdam, The Netherlands) were filled via acoustic drop ejection using the echo liquid hand...


US Patent US10131673 (2018)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM301488
PNG
(N-(2-(2-(9-(dimethylamino)-5,6,7,8-tetrahydropyraz...)
Show SMILES CN(C)c1c2CCCCc2nc2cc(nn12)C1CCCCN1C(=O)c1cc(C)ccc1NS(C)(=O)=O
Show InChI InChI=1S/C26H34N6O3S/c1-17-12-13-21(29-36(4,34)35)19(15-17)26(33)31-14-8-7-11-23(31)22-16-24-27-20-10-6-5-9-18(20)25(30(2)3)32(24)28-22/h12-13,15-16,23,29H,5-11,14H2,1-4H3
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n/an/an/an/a 1.78n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Black 384-well clear-bottom microtiter plates (Corning, Amsterdam, The Netherlands) were filled via acoustic drop ejection using the echo liquid hand...


US Patent US10131673 (2018)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM301474
PNG
(US10131673, Compound P1)
Show SMILES Cc1ccc(NS(C)(=O)=O)c(c1)C(=O)N1CCCCC1c1cc2nc3CCCCc3c(N3CCOCC3)n2n1
Show InChI InChI=1S/C28H36N6O4S/c1-19-10-11-23(31-39(2,36)37)21(17-19)28(35)33-12-6-5-9-25(33)24-18-26-29-22-8-4-3-7-20(22)27(34(26)30-24)32-13-15-38-16-14-32/h10-11,17-18,25,31H,3-9,12-16H2,1-2H3
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n/an/an/an/a 1.78n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Black 384-well clear-bottom microtiter plates (Corning, Amsterdam, The Netherlands) were filled via acoustic drop ejection using the echo liquid hand...


US Patent US10131673 (2018)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324745
PNG
(1'-({5-Chloro-1-[3- (methylsulfonyl)propyl]-1H- be...)
Show SMILES CS(=O)(=O)CCCn1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12
Show InChI InChI=1S/C21H21ClN4O3S/c1-30(28,29)10-2-9-25-17-4-3-14(22)11-16(17)24-19(25)13-26-18-12-23-8-5-15(18)21(6-7-21)20(26)27/h3-5,8,11-12H,2,6-7,9-10,13H2,1H3
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n/an/an/an/a 2n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM301500
PNG
(N-(2-(2-(5-(dimethylamino)-9-methyl-6,7,8,9-tetrah...)
Show SMILES CN(C)c1nc2cc(nn2c2N(C)CCCc12)C1CCCCN1C(=O)c1cc(C)ccc1NS(C)(=O)=O
Show InChI InChI=1S/C26H35N7O3S/c1-17-11-12-20(29-37(5,35)36)19(15-17)26(34)32-14-7-6-10-22(32)21-16-23-27-24(30(2)3)18-9-8-13-31(4)25(18)33(23)28-21/h11-12,15-16,22,29H,6-10,13-14H2,1-5H3
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n/an/an/an/a 2.04n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Black 384-well clear-bottom microtiter plates (Corning, Amsterdam, The Netherlands) were filled via acoustic drop ejection using the echo liquid hand...


US Patent US10131673 (2018)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324694
PNG
(1''-[{5-Chloro-1-[3- (methylsulfonyl)propyl]-1H-in...)
Show SMILES CS(=O)(=O)CCCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)ccc12
Show InChI InChI=1S/C22H22ClN3O3S/c1-30(28,29)10-2-9-25-17(12-15-11-16(23)3-4-19(15)25)14-26-20-13-24-8-5-18(20)22(6-7-22)21(26)27/h3-5,8,11-13H,2,6-7,9-10,14H2,1H3
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n/an/an/an/a 3n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324714
PNG
(1'-({5-Chloro-1-[3- (ethylsulfonyl)propyl]-1H-indo...)
Show SMILES CCS(=O)(=O)CCCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)ccc12
Show InChI InChI=1S/C23H24ClN3O3S/c1-2-31(29,30)11-3-10-26-18(13-16-12-17(24)4-5-20(16)26)15-27-21-14-25-9-6-19(21)23(7-8-23)22(27)28/h4-6,9,12-14H,2-3,7-8,10-11,15H2,1H3
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n/an/an/an/a 3n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324750
PNG
(1'-({5-Chloro-1-[2-(oxetan-3- yl)ethyl]-1H-benzimi...)
Show SMILES Clc1ccc2n(CCC3COC3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C22H21ClN4O2/c23-15-1-2-18-17(9-15)25-20(26(18)8-4-14-12-29-13-14)11-27-19-10-24-7-3-16(19)22(5-6-22)21(27)28/h1-3,7,9-10,14H,4-6,8,11-13H2
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n/an/an/an/a 3n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324749
PNG
(1'-{[5-Chloro-1-(oxetan-3-ylmethyl)- 1H-benzimidaz...)
Show SMILES Clc1ccc2n(CC3COC3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C21H19ClN4O2/c22-14-1-2-17-16(7-14)24-19(25(17)9-13-11-28-12-13)10-26-18-8-23-6-3-15(18)21(4-5-21)20(26)27/h1-3,6-8,13H,4-5,9-12H2
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n/an/an/an/a 3n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324648
PNG
(1'-({5-Chloro-7-fluoro-1-[2- (methylsulfonyl)ethyl...)
Show SMILES CS(=O)(=O)CCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)cc(F)c12
Show InChI InChI=1S/C21H19ClFN3O3S/c1-30(28,29)7-6-25-15(9-13-8-14(22)10-17(23)19(13)25)12-26-18-11-24-5-2-16(18)21(3-4-21)20(26)27/h2,5,8-11H,3-4,6-7,12H2,1H3
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n/an/an/an/a 3.40n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324737
PNG
(1'-({6-Chloro-3-[2- (methylsulfonyl)ethyl]-1H-indo...)
Show SMILES CS(=O)(=O)CCc1c(CN2C(=O)C3(CC3)c3ccncc23)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C21H20ClN3O3S/c1-29(27,28)9-5-15-14-3-2-13(22)10-17(14)24-18(15)12-25-19-11-23-8-4-16(19)21(6-7-21)20(25)26/h2-4,8,10-11,24H,5-7,9,12H2,1H3
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n/an/an/an/a 5n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324663
PNG
(1'-({5-Chloro-1-[4- (methylsulfonyl)butyl]-1H-indo...)
Show SMILES CS(=O)(=O)CCCCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)ccc12
Show InChI InChI=1S/C23H24ClN3O3S/c1-31(29,30)11-3-2-10-26-18(13-16-12-17(24)4-5-20(16)26)15-27-21-14-25-9-6-19(21)23(7-8-23)22(27)28/h4-6,9,12-14H,2-3,7-8,10-11,15H2,1H3
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n/an/an/an/a 5.90n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324698
PNG
(1'-({5-Chloro-1-[3-(S- methylsulfomidoyl)propyl]-1...)
Show SMILES CS(=N)(=O)CCCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)ccc12
Show InChI InChI=1S/C22H23ClN4O2S/c1-30(24,29)10-2-9-26-17(12-15-11-16(23)3-4-19(15)26)14-27-20-13-25-8-5-18(20)22(6-7-22)21(27)28/h3-5,8,11-13,24H,2,6-7,9-10,14H2,1H3
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n/an/an/an/a 6n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324729
PNG
(1'-[(5-Chloro-1-{2-[4- (methylsulfonyl)piperazin-1...)
Show SMILES CS(=O)(=O)N1CCN(CCn2c(CN3C(=O)C4(CC4)c4ccncc34)cc3cc(Cl)ccc23)CC1
Show InChI InChI=1S/C25H28ClN5O3S/c1-35(33,34)29-11-8-28(9-12-29)10-13-30-20(15-18-14-19(26)2-3-22(18)30)17-31-23-16-27-7-4-21(23)25(5-6-25)24(31)32/h2-4,7,14-16H,5-6,8-13,17H2,1H3
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n/an/an/an/a 6n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324738
PNG
(1'-({6-Chloro-3-[3- (methylsulfonyl)propyl]-1H-ind...)
Show SMILES CS(=O)(=O)CCCc1c(CN2C(=O)C3(CC3)c3ccncc23)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C22H22ClN3O3S/c1-30(28,29)10-2-3-15-16-5-4-14(23)11-18(16)25-19(15)13-26-20-12-24-9-6-17(20)22(7-8-22)21(26)27/h4-6,9,11-12,25H,2-3,7-8,10,13H2,1H3
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n/an/an/an/a 6n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM301480
PNG
(BDBM301481 | US10131673, Compound P7)
Show SMILES Cc1cccc2nc(NS(C)(=O)=O)nc(N3CCCCC3c3cc4nc5CCCCc5c(N5CCOCC5)n4n3)c12
Show InChI InChI=1S/C29H36N8O3S/c1-19-8-7-11-22-26(19)27(32-29(31-22)34-41(2,38)39)36-13-6-5-12-24(36)23-18-25-30-21-10-4-3-9-20(21)28(37(25)33-23)35-14-16-40-17-15-35/h7-8,11,18,24H,3-6,9-10,12-17H2,1-2H3,(H,31,32,34)
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n/an/an/an/a 6.03n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Black 384-well clear-bottom microtiter plates (Corning, Amsterdam, The Netherlands) were filled via acoustic drop ejection using the echo liquid hand...


US Patent US10131673 (2018)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324687
PNG
(1'-[(5-Chloro-1-{3-[(3-oxopiperazin- 1-yl)sulfonyl...)
Show SMILES Clc1ccc2n(CCCS(=O)(=O)N3CCNC(=O)C3)c(CN3C(=O)C4(CC4)c4ccncc34)cc2c1
Show InChI InChI=1S/C25H26ClN5O4S/c26-18-2-3-21-17(12-18)13-19(15-31-22-14-27-7-4-20(22)25(5-6-25)24(31)33)30(21)9-1-11-36(34,35)29-10-8-28-23(32)16-29/h2-4,7,12-14H,1,5-6,8-11,15-16H2,(H,28,32)
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n/an/an/an/a 7n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324682
PNG
(3-{5-Chloro-2-[(2'- oxospiro[cyclopropane-1,3'- py...)
Show SMILES CN(C)S(=O)(=O)CCCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)ccc12
Show InChI InChI=1S/C23H25ClN4O3S/c1-26(2)32(30,31)11-3-10-27-18(13-16-12-17(24)4-5-20(16)27)15-28-21-14-25-9-6-19(21)23(7-8-23)22(28)29/h4-6,9,12-14H,3,7-8,10-11,15H2,1-2H3
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n/an/an/an/a 7n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324699
PNG
(1'-({5-Chloro-1-[2-(S- methylsulfonimidoyl)ethyl]-...)
Show SMILES CS(=N)(=O)CCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)ccc12
Show InChI InChI=1S/C21H21ClN4O2S/c1-29(23,28)9-8-25-16(11-14-10-15(22)2-3-18(14)25)13-26-19-12-24-7-4-17(19)21(5-6-21)20(26)27/h2-4,7,10-12,23H,5-6,8-9,13H2,1H3
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n/an/an/an/a 7n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324651
PNG
(1'-({5-Chloro-1-[2- (ethylsulfonyl)ethyl]-1H-indol...)
Show SMILES CCS(=O)(=O)CCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)ccc12
Show InChI InChI=1S/C22H22ClN3O3S/c1-2-30(28,29)10-9-25-17(12-15-11-16(23)3-4-19(15)25)14-26-20-13-24-8-5-18(20)22(6-7-22)21(26)27/h3-5,8,11-13H,2,6-7,9-10,14H2,1H3
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n/an/an/an/a 7.67n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324746
PNG
(1'-({5-Chloro-1-[2- (cyclopropylsulfonyl)ethyl]-1H...)
Show SMILES Clc1ccc2n(CCS(=O)(=O)C3CC3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C22H21ClN4O3S/c23-14-1-4-18-17(11-14)25-20(26(18)9-10-31(29,30)15-2-3-15)13-27-19-12-24-8-5-16(19)22(6-7-22)21(27)28/h1,4-5,8,11-12,15H,2-3,6-7,9-10,13H2
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n/an/an/an/a 8n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324679
PNG
(1'-({5-Chloro-1-[3- (methylsulfinyl)propyl]-1H-ind...)
Show SMILES CS(=O)CCCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)ccc12
Show InChI InChI=1S/C22H22ClN3O2S/c1-29(28)10-2-9-25-17(12-15-11-16(23)3-4-19(15)25)14-26-20-13-24-8-5-18(20)22(6-7-22)21(26)27/h3-5,8,11-13H,2,6-7,9-10,14H2,1H3
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n/an/an/an/a 9n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324747
PNG
(1'-({5-Chloro-7-fluoro-1-[2- (methylsulfonyl)ethyl...)
Show SMILES CS(=O)(=O)CCn1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)cc(F)c12
Show InChI InChI=1S/C20H18ClFN4O3S/c1-30(28,29)7-6-25-17(24-15-9-12(21)8-14(22)18(15)25)11-26-16-10-23-5-2-13(16)20(3-4-20)19(26)27/h2,5,8-10H,3-4,6-7,11H2,1H3
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n/an/an/an/a 9n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324649
PNG
(1'-({5-Methyl-1-[2- (methylsulfonyl)ethyl]-1H-indo...)
Show SMILES Cc1ccc2n(CCS(C)(=O)=O)c(CN3C(=O)C4(CC4)c4ccncc34)cc2c1
Show InChI InChI=1S/C22H23N3O3S/c1-15-3-4-19-16(11-15)12-17(24(19)9-10-29(2,27)28)14-25-20-13-23-8-5-18(20)22(6-7-22)21(25)26/h3-5,8,11-13H,6-7,9-10,14H2,1-2H3
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n/an/an/an/a 9n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324736
PNG
(1'-({6-Chloro-3-[2- (ethylsulfonyl)ethyl]-1H-indol...)
Show SMILES CCS(=O)(=O)CCc1c(CN2C(=O)C3(CC3)c3cccnc23)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C22H22ClN3O3S/c1-2-30(28,29)11-7-16-15-6-5-14(23)12-18(15)25-19(16)13-26-20-17(4-3-10-24-20)22(8-9-22)21(26)27/h3-6,10,12,25H,2,7-9,11,13H2,1H3
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n/an/an/an/a 9n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324724
PNG
(3-{5-Chloro-2-[(2'- oxospiro[cyclopropane-1,3'- py...)
Show SMILES CNS(=O)(=O)CCCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)ccc12
Show InChI InChI=1S/C22H23ClN4O3S/c1-24-31(29,30)10-2-9-26-17(12-15-11-16(23)3-4-19(15)26)14-27-20-13-25-8-5-18(20)22(6-7-22)21(27)28/h3-5,8,11-13,24H,2,6-7,9-10,14H2,1H3
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n/an/an/an/a 11n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324708
PNG
(4-{5-Chloro-2-[(2'- oxospiro[cyclopropane-1,3'- py...)
Show SMILES NC(=O)CCCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)ccc12
Show InChI InChI=1S/C22H21ClN4O2/c23-15-3-4-18-14(10-15)11-16(26(18)9-1-2-20(24)28)13-27-19-12-25-8-5-17(19)22(6-7-22)21(27)29/h3-5,8,10-12H,1-2,6-7,9,13H2,(H2,24,28)
PDB

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n/an/an/an/a 11n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324730
PNG
(N-(2-{5-Chloro-2-[(2'- oxospiro[cyclopropane-1,3'-...)
Show SMILES CS(=O)(=O)NCCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)ccc12
Show InChI InChI=1S/C21H21ClN4O3S/c1-30(28,29)24-8-9-25-16(11-14-10-15(22)2-3-18(14)25)13-26-19-12-23-7-4-17(19)21(5-6-21)20(26)27/h2-4,7,10-12,24H,5-6,8-9,13H2,1H3
PDB

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n/an/an/an/a 11.5n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324739
PNG
(1'-({5-Chloro-1-[2- (methylsulfonyl)ethyl]-1H- ben...)
Show SMILES CS(=O)(=O)CCn1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12
Show InChI InChI=1S/C20H19ClN4O3S/c1-29(27,28)9-8-24-16-3-2-13(21)10-15(16)23-18(24)12-25-17-11-22-7-4-14(17)20(5-6-20)19(25)26/h2-4,7,10-11H,5-6,8-9,12H2,1H3
PDB

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n/an/an/an/a 12n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324743
PNG
(1'-({5-Chloro-1-[2- (ethylsulfonyl)ethyl]-1H- benz...)
Show SMILES CCS(=O)(=O)CCn1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12
Show InChI InChI=1S/C21H21ClN4O3S/c1-2-30(28,29)10-9-25-17-4-3-14(22)11-16(17)24-19(25)13-26-18-12-23-8-5-15(18)21(6-7-21)20(26)27/h3-5,8,11-12H,2,6-7,9-10,13H2,1H3
PDB

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n/an/an/an/a 13n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM301475
PNG
(US10131673, Compound P2)
Show SMILES Cc1ccc(NS(C)(=O)=O)c(c1)C(=O)N1CCCC[C@@H]1c1cc2nc3CCCCc3c(N3CCOCC3)n2n1
Show InChI InChI=1S/C28H36N6O4S/c1-19-10-11-23(31-39(2,36)37)21(17-19)28(35)33-12-6-5-9-25(33)24-18-26-29-22-8-4-3-7-20(22)27(34(26)30-24)32-13-15-38-16-14-32/h10-11,17-18,25,31H,3-9,12-16H2,1-2H3/t25-/m1/s1
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n/an/an/an/a 13.2n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Black 384-well clear-bottom microtiter plates (Corning, Amsterdam, The Netherlands) were filled via acoustic drop ejection using the echo liquid hand...


US Patent US10131673 (2018)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM301482
PNG
(US10131673, Compound P9)
Show SMILES Cc1ccc2nc(NS(C)(=O)=O)nc(N3CCCCC3c3cc4nc5CCCCc5c(N5CCOCC5)n4n3)c2c1
Show InChI InChI=1S/C29H36N8O3S/c1-19-10-11-23-21(17-19)27(32-29(31-23)34-41(2,38)39)36-12-6-5-9-25(36)24-18-26-30-22-8-4-3-7-20(22)28(37(26)33-24)35-13-15-40-16-14-35/h10-11,17-18,25H,3-9,12-16H2,1-2H3,(H,31,32,34)
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n/an/an/an/a 13.5n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Black 384-well clear-bottom microtiter plates (Corning, Amsterdam, The Netherlands) were filled via acoustic drop ejection using the echo liquid hand...


US Patent US10131673 (2018)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324685
PNG
(1'-({5-Chloro-1-[3-(morpholin-4- ylsulfonyl)propyl...)
Show SMILES Clc1ccc2n(CCCS(=O)(=O)N3CCOCC3)c(CN3C(=O)C4(CC4)c4ccncc34)cc2c1
Show InChI InChI=1S/C25H27ClN4O4S/c26-19-2-3-22-18(14-19)15-20(29(22)8-1-13-35(32,33)28-9-11-34-12-10-28)17-30-23-16-27-7-4-21(23)25(5-6-25)24(30)31/h2-4,7,14-16H,1,5-6,8-13,17H2
PDB

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n/an/an/an/a 14n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324641
PNG
(1'-({5-Bromo-1-[2- (methylsulfonyl)ethyl]-1H-indol...)
Show SMILES CS(=O)(=O)CCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Br)ccc12
Show InChI InChI=1S/C21H20BrN3O3S/c1-29(27,28)9-8-24-16(11-14-10-15(22)2-3-18(14)24)13-25-19-12-23-7-4-17(19)21(5-6-21)20(25)26/h2-4,7,10-12H,5-6,8-9,13H2,1H3
PDB

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n/an/an/an/a 14n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324719
PNG
(1'-({5-Chloro-1-[3-(piperazin-1- ylsulfonyl)propyl...)
Show SMILES Clc1ccc2n(CCCS(=O)(=O)N3CCNCC3)c(CN3C(=O)C4(CC4)c4ccncc34)cc2c1
Show InChI InChI=1S/C25H28ClN5O3S/c26-19-2-3-22-18(14-19)15-20(30(22)10-1-13-35(33,34)29-11-8-27-9-12-29)17-31-23-16-28-7-4-21(23)25(5-6-25)24(31)32/h2-4,7,14-16,27H,1,5-6,8-13,17H2
PDB

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n/an/an/an/a 15n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM301515
PNG
(N,N,5-trimethyl-2-(1-(5-methylquinazolin-4-yl)pipe...)
Show SMILES CN(C)c1c2CCN(C)c2nc2cc(nn12)C1CCCCN1c1ncnc2cccc(C)c12
Show InChI InChI=1S/C25H30N8/c1-16-8-7-9-18-22(16)24(27-15-26-18)32-12-6-5-10-20(32)19-14-21-28-23-17(11-13-31(23)4)25(30(2)3)33(21)29-19/h7-9,14-15,20H,5-6,10-13H2,1-4H3
PDB

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n/an/an/an/a 16.6n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Black 384-well clear-bottom microtiter plates (Corning, Amsterdam, The Netherlands) were filled via acoustic drop ejection using the echo liquid hand...


US Patent US10131673 (2018)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324748
PNG
(1'-({5,7-Dichloro-1-[2- (methylsulfonyl)ethyl]-1H-...)
Show SMILES CS(=O)(=O)CCn1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)cc(Cl)c12
Show InChI InChI=1S/C20H18Cl2N4O3S/c1-30(28,29)7-6-25-17(24-15-9-12(21)8-14(22)18(15)25)11-26-16-10-23-5-2-13(16)20(3-4-20)19(26)27/h2,5,8-10H,3-4,6-7,11H2,1H3
PDB

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n/an/an/an/a 16.8n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324706
PNG
(3-{5-Chloro-2-[(2'- oxospiro[cyclopropane-1,3'- py...)
Show SMILES NC(=O)CCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)ccc12
Show InChI InChI=1S/C21H19ClN4O2/c22-14-1-2-17-13(9-14)10-15(25(17)8-4-19(23)27)12-26-18-11-24-7-3-16(18)21(5-6-21)20(26)28/h1-3,7,9-11H,4-6,8,12H2,(H2,23,27)
PDB

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n/an/an/an/a 17n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324673
PNG
(1'-({5-Chloro-1-[2-(1,1- dioxidothietan-3-yl)ethyl...)
Show SMILES Clc1cc2cc(CN3C(=O)C4(CC4)c4ccncc34)n(CCC3CS(=O)(=O)C3)c2cn1
Show InChI InChI=1S/C22H21ClN4O3S/c23-20-8-15-7-16(26(18(15)10-25-20)6-2-14-12-31(29,30)13-14)11-27-19-9-24-5-1-17(19)22(3-4-22)21(27)28/h1,5,7-10,14H,2-4,6,11-13H2
PDB

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n/an/an/an/a 18n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324697
PNG
(Ethyl 3-{5-chloro-7-fluoro-2-[(2'- oxospiro[cyclop...)
Show SMILES CCOC(=O)CCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)cc(F)c12
Show InChI InChI=1S/C23H21ClFN3O3/c1-2-31-20(29)4-8-27-16(10-14-9-15(24)11-18(25)21(14)27)13-28-19-12-26-7-3-17(19)23(5-6-23)22(28)30/h3,7,9-12H,2,4-6,8,13H2,1H3
PDB

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n/an/an/an/a 18n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324689
PNG
(1'-({5-Chloro-1-[4-(1,1-dioxido-1,2- thiazolidin-2...)
Show SMILES Clc1ccc2n(CCCCN3CCCS3(=O)=O)c(CN3C(=O)C4(CC4)c4ccncc34)cc2c1
Show InChI InChI=1S/C25H27ClN4O3S/c26-19-4-5-22-18(14-19)15-20(29(22)12-2-1-10-28-11-3-13-34(28,32)33)17-30-23-16-27-9-6-21(23)25(7-8-25)24(30)31/h4-6,9,14-16H,1-3,7-8,10-13,17H2
PDB

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n/an/an/an/a 18n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324662
PNG
(1''-({5-Chloro-1-[2- (methylsulfonyl)ethyl]-1H-ind...)
Show SMILES CS(=O)(=O)CCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)ccc12
Show InChI InChI=1S/C21H20ClN3O3S/c1-29(27,28)9-8-24-16(11-14-10-15(22)2-3-18(14)24)13-25-19-12-23-7-4-17(19)21(5-6-21)20(25)26/h2-4,7,10-12H,5-6,8-9,13H2,1H3
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n/an/an/an/a 18n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324677
PNG
(1'-({5-Chloro-1-[3- (methylsulfonyl)propyl]-1H- py...)
Show SMILES CS(=O)(=O)CCCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2nc(Cl)ccc12
Show InChI InChI=1S/C21H21ClN4O3S/c1-30(28,29)10-2-9-25-14(11-16-17(25)3-4-19(22)24-16)13-26-18-12-23-8-5-15(18)21(6-7-21)20(26)27/h3-5,8,11-12H,2,6-7,9-10,13H2,1H3
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n/an/an/an/a 18n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324752
PNG
(1'-({1-[(3-Aminooxetan-3- yl)methyl]-5-chloro-1H- ...)
Show SMILES NC1(Cn2c(CN3C(=O)C4(CC4)c4ccncc34)nc3cc(Cl)ccc23)COC1
Show InChI InChI=1S/C21H20ClN5O2/c22-13-1-2-16-15(7-13)25-18(27(16)10-20(23)11-29-12-20)9-26-17-8-24-6-3-14(17)21(4-5-21)19(26)28/h1-3,6-8H,4-5,9-12,23H2
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n/an/an/an/a 18n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324705
PNG
(Methyl 4-{5-chloro-2-[(2'- oxospiro[cyclopropane-1...)
Show SMILES COC(=O)CCCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)ccc12
Show InChI InChI=1S/C23H22ClN3O3/c1-30-21(28)3-2-10-26-17(12-15-11-16(24)4-5-19(15)26)14-27-20-13-25-9-6-18(20)23(7-8-23)22(27)29/h4-6,9,11-13H,2-3,7-8,10,14H2,1H3
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n/an/an/an/a 18.6n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324652
PNG
(1'-({5-Chloro-1-[2- (ethylsulfonyl)ethyl]-1H-pyrro...)
Show SMILES CCS(=O)(=O)CCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)cnc12
Show InChI InChI=1S/C21H21ClN4O3S/c1-2-30(28,29)8-7-25-16(10-14-9-15(22)11-24-19(14)25)13-26-18-12-23-6-3-17(18)21(4-5-21)20(26)27/h3,6,9-12H,2,4-5,7-8,13H2,1H3
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n/an/an/an/a 19n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324720
PNG
(1'-[(5-Chloro-1-{3-[(1R,4R)-2,5- diazabicyclo[2.2....)
Show SMILES Clc1ccc2n(CCCS(=O)(=O)N3C[C@H]4C[C@@H]3CN4)c(CN3C(=O)C4(CC4)c4ccncc34)cc2c1
Show InChI InChI=1S/C26H28ClN5O3S/c27-18-2-3-23-17(10-18)11-21(16-31-24-14-28-7-4-22(24)26(5-6-26)25(31)33)30(23)8-1-9-36(34,35)32-15-19-12-20(32)13-29-19/h2-4,7,10-11,14,19-20,29H,1,5-6,8-9,12-13,15-16H2/t19-,20-/m1/s1
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n/an/an/an/a 19n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324662
PNG
(1''-({5-Chloro-1-[2- (methylsulfonyl)ethyl]-1H-ind...)
Show SMILES CS(=O)(=O)CCn1c(CN2C(=O)C3(CC3)c3ccncc23)cc2cc(Cl)ccc12
Show InChI InChI=1S/C21H20ClN3O3S/c1-29(27,28)9-8-24-16(11-14-10-15(22)2-3-18(14)24)13-25-19-12-23-7-4-17(19)21(5-6-21)20(25)26/h2-4,7,10-12H,5-6,8-9,13H2,1H3
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n/an/an/an/a 19n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair
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