BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1568 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 4'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190443
PNG
(US9180192, 38)
Show SMILES Cc1cc(cnc1Cl)S(=O)(=O)n1cc(NC(=O)c2ccccn2)cn1
Show InChI InChI=1S/C15H12ClN5O3S/c1-10-6-12(8-18-14(10)16)25(23,24)21-9-11(7-19-21)20-15(22)13-4-2-3-5-17-13/h2-9H,1H3,(H,20,22)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 2.05E-7n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190436
PNG
(US9180192, 31)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1ccc2OCOc2c1)c1ccccn1
Show InChI InChI=1S/C16H12N4O5S/c21-16(13-3-1-2-6-17-13)19-11-8-18-20(9-11)26(22,23)12-4-5-14-15(7-12)25-10-24-14/h1-9H,10H2,(H,19,21)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 2.16E-7n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190442
PNG
(US9180192, 37)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1cnc2ccccc2c1)c1ccccn1
Show InChI InChI=1S/C18H13N5O3S/c24-18(17-7-3-4-8-19-17)22-14-10-21-23(12-14)27(25,26)15-9-13-5-1-2-6-16(13)20-11-15/h1-12H,(H,22,24)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 2.23E-7n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190439
PNG
(US9180192, 34)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1ccc2OCCCOc2c1)c1ccccn1
Show InChI InChI=1S/C18H16N4O5S/c23-18(15-4-1-2-7-19-15)21-13-11-20-22(12-13)28(24,25)14-5-6-16-17(10-14)27-9-3-8-26-16/h1-2,4-7,10-12H,3,8-9H2,(H,21,23)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 2.40E-7n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190441
PNG
(US9180192, 36)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1ccc2occc2c1)c1ccccn1
Show InChI InChI=1S/C17H12N4O4S/c22-17(15-3-1-2-7-18-15)20-13-10-19-21(11-13)26(23,24)14-4-5-16-12(9-14)6-8-25-16/h1-11H,(H,20,22)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 2.50E-7n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190444
PNG
(US9180192, 39)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1ccc2OCCOc2c1)c1ccccn1
Show InChI InChI=1S/C17H14N4O5S/c22-17(14-3-1-2-6-18-14)20-12-10-19-21(11-12)27(23,24)13-4-5-15-16(9-13)26-8-7-25-15/h1-6,9-11H,7-8H2,(H,20,22)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 3.35E-7n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190447
PNG
(US9180192, 42)
Show SMILES Clc1cccc(n1)S(=O)(=O)n1cc(NC(=O)c2ccccn2)cn1
Show InChI InChI=1S/C14H10ClN5O3S/c15-12-5-3-6-13(19-12)24(22,23)20-9-10(8-17-20)18-14(21)11-4-1-2-7-16-11/h1-9H,(H,18,21)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.48E-7n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190448
PNG
(US9180192, 43)
Show SMILES COc1ccc(cn1)S(=O)(=O)n1cc(NC(=O)c2ccccn2)cn1
Show InChI InChI=1S/C15H13N5O4S/c1-24-14-6-5-12(9-17-14)25(22,23)20-10-11(8-18-20)19-15(21)13-4-2-3-7-16-13/h2-10H,1H3,(H,19,21)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 6.40E-7n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190451
PNG
(US9180192, 46)
Show SMILES Clc1ccc(cn1)S(=O)(=O)n1cc(NC(=O)c2ccccn2)cn1
Show InChI InChI=1S/C14H10ClN5O3S/c15-13-5-4-11(8-17-13)24(22,23)20-9-10(7-18-20)19-14(21)12-3-1-2-6-16-12/h1-9H,(H,19,21)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 0.00000101n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190438
PNG
(US9180192, 33)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1ccsc1)c1ccccn1
Show InChI InChI=1S/C13H10N4O3S2/c18-13(12-3-1-2-5-14-12)16-10-7-15-17(8-10)22(19,20)11-4-6-21-9-11/h1-9H,(H,16,18)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.00000106n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190450
PNG
(US9180192, 45)
Show SMILES Cc1ccc(o1)S(=O)(=O)n1cc(NC(=O)c2ccccn2)cn1
Show InChI InChI=1S/C14H12N4O4S/c1-10-5-6-13(22-10)23(20,21)18-9-11(8-16-18)17-14(19)12-4-2-3-7-15-12/h2-9H,1H3,(H,17,19)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 0.00000128n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190440
PNG
(US9180192, 35)
Show SMILES CC1(C)CCc2ccc(cc2O1)S(=O)(=O)n1cc(NC(=O)c2ccccn2)cn1
Show InChI InChI=1S/C20H20N4O4S/c1-20(2)9-8-14-6-7-16(11-18(14)28-20)29(26,27)24-13-15(12-22-24)23-19(25)17-5-3-4-10-21-17/h3-7,10-13H,8-9H2,1-2H3,(H,23,25)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.00000150n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190437
PNG
(US9180192, 32)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1ccc(cc1)N1CCOCC1)c1ccccn1
Show InChI InChI=1S/C19H19N5O4S/c25-19(18-3-1-2-8-20-18)22-15-13-21-24(14-15)29(26,27)17-6-4-16(5-7-17)23-9-11-28-12-10-23/h1-8,13-14H,9-12H2,(H,22,25)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 0.00000182n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190445
PNG
(US9180192, 40)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1ccoc1)c1ccccn1
Show InChI InChI=1S/C13H10N4O4S/c18-13(12-3-1-2-5-14-12)16-10-7-15-17(8-10)22(19,20)11-4-6-21-9-11/h1-9H,(H,16,18)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.00000231n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190446
PNG
(US9180192, 41)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1ccco1)c1ccccn1
Show InChI InChI=1S/C13H10N4O4S/c18-13(11-4-1-2-6-14-11)16-10-8-15-17(9-10)22(19,20)12-5-3-7-21-12/h1-9H,(H,16,18)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 0.00000245n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190452
PNG
(US9180192, 47)
Show SMILES Cc1nc(C)c(s1)S(=O)(=O)n1cc(NC(=O)c2ccccn2)cn1
Show InChI InChI=1S/C14H13N5O3S2/c1-9-14(23-10(2)17-9)24(21,22)19-8-11(7-16-19)18-13(20)12-5-3-4-6-15-12/h3-8H,1-2H3,(H,18,20)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.00000642n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190449
PNG
(US9180192, 44)
Show SMILES Clc1ncccc1S(=O)(=O)n1cc(NC(=O)c2ccccn2)cn1
Show InChI InChI=1S/C14H10ClN5O3S/c15-13-12(5-3-7-17-13)24(22,23)20-9-10(8-18-20)19-14(21)11-4-1-2-6-16-11/h1-9H,(H,19,21)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/an/an/a 0.00000737n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)


BindingDB Entry DOI: 10.7270/Q26972C0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166956
PNG
(CHEMBL3798517)
Show SMILES CCc1cnc(Oc2ccc(NC(=O)c3ncccc3N)cc2Cl)nc1
Show InChI InChI=1S/C18H16ClN5O2/c1-2-11-9-22-18(23-10-11)26-15-6-5-12(8-13(15)19)24-17(25)16-14(20)4-3-7-21-16/h3-10H,2,20H2,1H3,(H,24,25)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.0650n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166968
PNG
(CHEMBL3798234)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H13ClN4O3/c21-14-10-11(24-18(26)17-15(22)6-3-9-23-17)7-8-16(14)25-19(27)12-4-1-2-5-13(12)20(25)28/h1-10H,22H2,(H,24,26)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.0950n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166972
PNG
(CHEMBL3798197)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2Cc3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H15ClN4O2/c21-15-10-13(24-19(26)18-16(22)6-3-9-23-18)7-8-17(15)25-11-12-4-1-2-5-14(12)20(25)27/h1-10H,11,22H2,(H,24,26)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.236n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166971
PNG
(CHEMBL3797445)
Show SMILES COc1ccc2CN(C(=O)c2c1)c1ccc(NC(=O)c2ncccc2N)cc1Cl
Show InChI InChI=1S/C21H17ClN4O3/c1-29-14-6-4-12-11-26(21(28)15(12)10-14)18-7-5-13(9-16(18)22)25-20(27)19-17(23)3-2-8-24-19/h2-10H,11,23H2,1H3,(H,25,27)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.319n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166975
PNG
(CHEMBL3799261)
Show SMILES Cc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ncccc2N)cc1Cl
Show InChI InChI=1S/C21H15ClN4O3/c1-11-4-2-5-13-17(11)21(29)26(20(13)28)16-8-7-12(10-14(16)22)25-19(27)18-15(23)6-3-9-24-18/h2-10H,23H2,1H3,(H,25,27)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.689n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166961
PNG
(CHEMBL3797923)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC(Cc3ccccc3)CC2=O)c(Cl)c1
Show InChI InChI=1/C23H21ClN4O2/c24-18-13-17(27-23(30)22-19(25)7-4-10-26-22)8-9-20(18)28-14-16(12-21(28)29)11-15-5-2-1-3-6-15/h1-10,13,16H,11-12,14,25H2,(H,27,30)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.758n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166974
PNG
(CHEMBL3797463)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CCc3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H17ClN4O2/c22-16-12-14(25-20(27)19-17(23)6-3-10-24-19)7-8-18(16)26-11-9-13-4-1-2-5-15(13)21(26)28/h1-8,10,12H,9,11,23H2,(H,25,27)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.921n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166958
PNG
(CHEMBL3798366)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC3(CC2=O)CCCCC3)c(Cl)c1
Show InChI InChI=1S/C21H23ClN4O2/c22-15-11-14(25-20(28)19-16(23)5-4-10-24-19)6-7-17(15)26-13-21(12-18(26)27)8-2-1-3-9-21/h4-7,10-11H,1-3,8-9,12-13,23H2,(H,25,28)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.30n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166969
PNG
(CHEMBL3797390)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2Cc3ncccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C19H14ClN5O2/c20-13-9-11(24-18(26)17-14(21)4-2-8-23-17)5-6-16(13)25-10-15-12(19(25)27)3-1-7-22-15/h1-9H,10,21H2,(H,24,26)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.30n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166955
PNG
(CHEMBL3798239)
Show SMILES Cc1ncc(Oc2ccc(NC(=O)c3ncccc3N)cc2Cl)cn1
Show InChI InChI=1S/C17H14ClN5O2/c1-10-21-8-12(9-22-10)25-15-5-4-11(7-13(15)18)23-17(24)16-14(19)3-2-6-20-16/h2-9H,19H2,1H3,(H,23,24)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.40n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166960
PNG
(CHEMBL3799708)
Show SMILES CC(C)CC1CN(C(=O)C1)c1ccc(NC(=O)c2ncccc2N)cc1Cl
Show InChI InChI=1/C20H23ClN4O2/c1-12(2)8-13-9-18(26)25(11-13)17-6-5-14(10-15(17)21)24-20(27)19-16(22)4-3-7-23-19/h3-7,10,12-13H,8-9,11,22H2,1-2H3,(H,24,27)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.60n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166963
PNG
(CHEMBL3797777)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC(CC2=O)c2c(F)cccc2Cl)c(Cl)c1
Show InChI InChI=1/C22H17Cl2FN4O2/c23-14-3-1-4-16(25)20(14)12-9-19(30)29(11-12)18-7-6-13(10-15(18)24)28-22(31)21-17(26)5-2-8-27-21/h1-8,10,12H,9,11,26H2,(H,28,31)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.90n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166967
PNG
(CHEMBL3798945)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2Cc3ccccc3CC2=O)c(Cl)c1
Show InChI InChI=1S/C21H17ClN4O2/c22-16-11-15(25-21(28)20-17(23)6-3-9-24-20)7-8-18(16)26-12-14-5-2-1-4-13(14)10-19(26)27/h1-9,11H,10,12,23H2,(H,25,28)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 2.20n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166962
PNG
(CHEMBL3799281)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC(CC2=O)c2cccnc2)c(Cl)c1
Show InChI InChI=1/C21H18ClN5O2/c22-16-10-15(26-21(29)20-17(23)4-2-8-25-20)5-6-18(16)27-12-14(9-19(27)28)13-3-1-7-24-11-13/h1-8,10-11,14H,9,12,23H2,(H,26,29)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 2.5n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166964
PNG
(CHEMBL3799999)
Show SMILES CC1(CN(C(=O)C1)c1ccc(NC(=O)c2ncccc2N)cc1Cl)C1CC1
Show InChI InChI=1/C20H21ClN4O2/c1-20(12-4-5-12)10-17(26)25(11-20)16-7-6-13(9-14(16)21)24-19(27)18-15(22)3-2-8-23-18/h2-3,6-9,12H,4-5,10-11,22H2,1H3,(H,24,27)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.80n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50241577
PNG
(CHEMBL4070594)
Show SMILES Cc1ncccc1N1CCC(Cc2ccc3oc(c\c(=N/O)c3c2)-c2cc3sccc3cn2)CC1
Show InChI InChI=1S/C28H26N4O2S/c1-18-25(3-2-9-29-18)32-10-6-19(7-11-32)13-20-4-5-26-22(14-20)23(31-33)15-27(34-26)24-16-28-21(17-30-24)8-12-35-28/h2-5,8-9,12,14-17,19,33H,6-7,10-11,13H2,1H3/b31-23+
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 4n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...


J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166973
PNG
(CHEMBL3798583)
Show SMILES CC1N(C(=O)c2ccccc12)c1ccc(NC(=O)c2ncccc2N)cc1Cl
Show InChI InChI=1/C21H17ClN4O2/c1-12-14-5-2-3-6-15(14)21(28)26(12)18-9-8-13(11-16(18)22)25-20(27)19-17(23)7-4-10-24-19/h2-12H,23H2,1H3,(H,25,27)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50116515
PNG
(CHEMBL3609729)
Show SMILES Cc1sc(Nc2nccc(C)n2)nc1-c1cn[nH]c1
Show InChI InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18)
UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 4n/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50241589
PNG
(CHEMBL4097743)
Show SMILES O\N=c1/cc(oc2ccc(OC3CN(C3)c3cccnc3)cc12)-c1cc2sccc2cn1
Show InChI InChI=1S/C24H18N4O3S/c29-27-20-9-23(21-10-24-15(11-26-21)5-7-32-24)31-22-4-3-17(8-19(20)22)30-18-13-28(14-18)16-2-1-6-25-12-16/h1-12,18,29H,13-14H2/b27-20+
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 4n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...


J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50241578
PNG
(CHEMBL4105462)
Show SMILES CC(=O)N1CCC(COc2ccc3oc(c\c(=N/O)c3c2)-c2cc3sccc3cn2)CC1
Show InChI InChI=1S/C24H23N3O4S/c1-15(28)27-7-4-16(5-8-27)14-30-18-2-3-22-19(10-18)20(26-29)11-23(31-22)21-12-24-17(13-25-21)6-9-32-24/h2-3,6,9-13,16,29H,4-5,7-8,14H2,1H3/b26-20+
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 6n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...


J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50353291
PNG
(CHEMBL1830711)
Show SMILES C1Cc2[nH]ncc2-c2nc(Nc3ncccn3)sc2C1
Show InChI InChI=1S/C13H12N6S/c1-3-9-8(7-16-19-9)11-10(4-1)20-13(17-11)18-12-14-5-2-6-15-12/h2,5-7H,1,3-4H2,(H,16,19)(H,14,15,17,18)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 7n/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization afte...


J Med Chem 54: 5070-81 (2011)


Article DOI: 10.1021/jm200290z
BindingDB Entry DOI: 10.7270/Q26110P5
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368576
PNG
(1-(1-fluoro-1-methyl- ethyl)-N-(1H- pyrazolo[3,4-b...)
Show SMILES CC(C)(F)c1nccc2cc(Nc3n[nH]c4nccnc34)ccc12
Show InChI InChI=1S/C17H15FN6/c1-17(2,18)14-12-4-3-11(9-10(12)5-6-20-14)22-16-13-15(23-24-16)21-8-7-19-13/h3-9H,1-2H3,(H2,21,22,23,24)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368526
PNG
(1-(difluoromethyl)-N- (1H-pyrazolo [4,3-b]pyridin-...)
Show SMILES FC(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C16H11F2N5/c17-15(18)13-11-4-3-10(8-9(11)5-7-20-13)21-16-14-12(22-23-16)2-1-6-19-14/h1-8,15H,(H2,21,22,23)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50353290
PNG
(CHEMBL1830707)
Show SMILES C1Cc2[nH]ncc2-c2nc(Nc3ccccn3)sc2C1
Show InChI InChI=1S/C14H13N5S/c1-2-7-15-12(6-1)17-14-18-13-9-8-16-19-10(9)4-3-5-11(13)20-14/h1-2,6-8H,3-5H2,(H,16,19)(H,15,17,18)
UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 9n/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization afte...


J Med Chem 54: 5070-81 (2011)


Article DOI: 10.1021/jm200290z
BindingDB Entry DOI: 10.7270/Q26110P5
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50353291
PNG
(CHEMBL1830711)
Show SMILES C1Cc2[nH]ncc2-c2nc(Nc3ncccn3)sc2C1
Show InChI InChI=1S/C13H12N6S/c1-3-9-8(7-16-19-9)11-10(4-1)20-13(17-11)18-12-14-5-2-6-15-12/h2,5-7H,1,3-4H2,(H,16,19)(H,14,15,17,18)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 9n/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50241594
PNG
(CHEMBL4082573)
Show SMILES CC(=O)N1CCC(CC1)Oc1ccc2oc(c\c(=N/O)c2c1)-c1cc2cccn2cn1
Show InChI InChI=1S/C23H22N4O4/c1-15(28)26-9-6-17(7-10-26)30-18-4-5-22-19(12-18)20(25-29)13-23(31-22)21-11-16-3-2-8-27(16)14-24-21/h2-5,8,11-14,17,29H,6-7,9-10H2,1H3/b25-20+
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 10n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...


J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166970
PNG
(CHEMBL3800490)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2Cc3ccc(Cl)cc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2N4O2/c21-12-4-3-11-10-26(20(28)14(11)8-12)17-6-5-13(9-15(17)22)25-19(27)18-16(23)2-1-7-24-18/h1-9H,10,23H2,(H,25,27)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>10n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166965
PNG
(CHEMBL3800516)
Show SMILES CC1(C)CN(C(=O)C1)c1ccc(NC(=O)c2ncccc2N)cc1Cl
Show InChI InChI=1S/C18H19ClN4O2/c1-18(2)9-15(24)23(10-18)14-6-5-11(8-12(14)19)22-17(25)16-13(20)4-3-7-21-16/h3-8H,9-10,20H2,1-2H3,(H,22,25)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>10n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166959
PNG
(CHEMBL3799197)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC3(CCCC3)CC2=O)c(Cl)c1
Show InChI InChI=1S/C20H21ClN4O2/c21-14-10-13(24-19(27)18-15(22)4-3-9-23-18)5-6-16(14)25-12-20(11-17(25)26)7-1-2-8-20/h3-6,9-10H,1-2,7-8,11-12,22H2,(H,24,27)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a>10n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166966
PNG
(CHEMBL3799524)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CCCC2=O)c(Cl)c1
Show InChI InChI=1S/C16H15ClN4O2/c17-11-9-10(5-6-13(11)21-8-2-4-14(21)22)20-16(23)15-12(18)3-1-7-19-15/h1,3,5-7,9H,2,4,8,18H2,(H,20,23)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>10n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166957
PNG
(CHEMBL3799087)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2C3CCC(C3)C2=O)c(Cl)c1
Show InChI InChI=1/C18H17ClN4O2/c19-13-9-11(22-17(24)16-14(20)2-1-7-21-16)4-6-15(13)23-12-5-3-10(8-12)18(23)25/h1-2,4,6-7,9-10,12H,3,5,8,20H2,(H,22,24)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a>10n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.041
BindingDB Entry DOI: 10.7270/Q2348N9V
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM368495
PNG
(4-fluoro-1-methyl-N- (1H-pyrazolo[4,3-b] pyridin-3...)
Show SMILES Cc1ncc(F)c2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C16H12FN5/c1-9-11-5-4-10(7-12(11)13(17)8-19-9)20-16-15-14(21-22-16)3-2-6-18-15/h2-8H,1H3,(H2,20,21,22)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 13n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US10227343 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50353332
PNG
(CHEMBL1830694)
Show SMILES Cc1sc(Nc2ccccn2)nc1-c1cn[nH]c1
Show InChI InChI=1S/C12H11N5S/c1-8-11(9-6-14-15-7-9)17-12(18-8)16-10-4-2-3-5-13-10/h2-7H,1H3,(H,14,15)(H,13,16,17)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 13n/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization afte...


J Med Chem 54: 5070-81 (2011)


Article DOI: 10.1021/jm200290z
BindingDB Entry DOI: 10.7270/Q26110P5
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 1568 total )  |  Next  |  Last  >>
Jump to: